Page last updated: 2024-08-21

pyrazines and 6-chloro-2-(1-piperazinyl)pyrazine

pyrazines has been researched along with 6-chloro-2-(1-piperazinyl)pyrazine in 141 studies

Research

Studies (141)

Timeframe	Studies, this research(%)	All Research%
pre-1990	44 (31.21)	18.7374
1990's	41 (29.08)	18.2507
2000's	29 (20.57)	29.6817
2010's	25 (17.73)	24.3611
2020's	2 (1.42)	2.80

Authors

Authors	Studies
Blatt, CM; Lown, B; Rabinowitz, SH	1
Weidner, LL; Wishousky, TI; Zacchei, AG	1
Clineschmidt, BV; McGuffin, JC	1
Clineschmidt, BV; Hanson, HM; McGuffin, JC; Pflueger, AB	1
Clineschidmt, BV	1
Clineschmidt, BV; McGuffin, JC; Pflueger, AB; Totaro, JA	2
Clineschmidt, BV; Mcguffin, JC; Pflueger, AB	1
Bethea, CL; Brownfield, MS; Carnes, M; Lent, SJ; O'Connor, P; Palionis, T; Rittenhouse, PA; Van de Kar, LD	1
Alvarez Sanz, MC; Brownfield, MS; Levy, AD; Li, Q; Rittenhouse, PA; Van de Kar, LD	1
Antunes-Rodrigues, J; Ramalho, MJ; Reis, LC	4
Kindler, S; Zohar, J	1
Antunes-Rodrigues, J; De-Castro-e-Silva, E; Ramalho, MJ; Reis, LC	1
Barr, LC; Charney, DS; Goodman, WK; McDougle, CJ; Price, LH	1
Bastani, B; Friedman, L; Lee, HS; Meltzer, HY; Ramirez, L	1
Benavidez, S; Carr, JA; Krobert, K; Saland, LC; Samora, A	1
Lee, MA; Meltzer, HY	2
Donát, P; Rodgers, RJ; Shepherd, JK	1
Berendsen, HH; Broekkamp, CL	4
Antunes-Rodrigues, J; de-Castro-e-Silva, E; Nonaka, K; Ramalho, MJ; Reis, LC	1
Sanders-Bush, E; Tsutsumi, M	1
Bastani, B; Meltzer, HY; Nash, JF	1
McKearney, JW	2
Anderson, EG; Todorovic, SM	1
Cooper, SJ; Neill, JC	1
Bethea, CL; Lorens, SA; Urban, JH; Van de Kar, LD	1
Gudelsky, GA; Meltzer, HY; Nash, JF	2
Brazell, C; Dourish, CT; King, BH; Middlemiss, DN	1
Meltzer, HY; Nash, JF	1
Frazer, A; Lucki, I; Ward, HR	1
Cazzamalli, E; Guidobono, F; Netti, C; Pecile, A; Sibilia, V; Villa, I	1
Quock, RM; Wojcechowskyj, JA	1
Barrett, JE; Bolger, GT; Mansbach, RS; Skolnick, P; Weissman, B; Witkin, JM	1
Barrett, JE; Brady, LS	1
Clineschmidt, BV; Pettibone, DJ; Reiss, DR; Robinson, JL	1
Barrett, JE; Mansbach, RS	1
Gudelsky, GA; Koenig, JI; Meltzer, HY	3
Lorens, SA; Van de Kar, LD	1
Harris, LT; McCall, RB; Patel, BN	1
Drejer, J; Honoré, T; Nielsen, M; Olverman, HJ; Watkins, JC	1
Appel, JB; Callahan, PM; Cunningham, KA	1
Lowy, MT; Meltzer, HY	1
Armstrong, J; Brownfield, MS; Greathouse, J; Lorens, SA; Urban, JH; Van de Kar, LD	1
Grome, JJ; Harper, AM	1
Huff, JR; King, SW; Martin, GE; Saari, WS; Springer, JP; Williams, M	1
Menon, MK; Vivonia, CA	2
Carino, MA; Fatherazi, S; Horita, A; Lai, H; Pae, YS	1
Moses, PL; Wurtman, RJ	1
Pettibone, DJ; Singh, DK; Yarbrough, GG	1
Appel, JB; White, FJ	1
Cheney, DL; McGill, W; Murray, TF	1
Neuman, RS; White, SR	1
Antelman, SM; Kocan, D; Rowland, N	1
Arnold, MA; Fernstrom, JD	1
Maes, M; Meltzer, HY	1
Antunes-Rodrigues, J; De Castro e Silva, E; Nonaka, KO; Ramalho, MJ; Reis, LC	1
Friedman, L; Jesberger, JA; Meltzer, HY	1
Maes, M; Meltzer, HY; Thompson, PA	1
Albinsson, A; Andersson, G; Palazidou, E; Stephenson, J	1
Jørgensen, H; Knigge, U; Warberg, J	1
Barber, DJ; Cooper, SJ	1
Battaglia, G; Brownfield, MS; Cabrera, TM; Levy, AD; Li, Q; Rittenhouse, PA; van de Kar, LD	1
Rabin, RA; Winter, JC	1
Fiorella, D; Helsley, S; Rabin, RA; Winter, JC	1
Berendsen, HH; Broekkamp, CL; Kester, RC; Peeters, BW	1
Fuller, RW; Hemrick-Luecke, SK	1
Blundell, JE; Halford, JC; Lawton, CL	1
Acton, L; Sharp, T; Smith, SE	1
Meltzer, HY; Willins, DL	1
Baumgarten, HG; Grozdanovic, Z	1
Ishikane, T	1
Dekeyne, A; Girardon, S; Millan, MJ	1
George, FR; Kreifeldt, MJ; O'Dell, LE; Ritz, MC	1
Di Giovanni, G; Di Mascio, M; Di Matteo, V; Esposito, E	1
Jordan, D; Sévoz-Couche, C; Spyer, KM	2
Arnt, J; Sánchez, C	1
Basura, GJ; Goshgarian, HG; Zhou, SY	1
Cunningham, KA; Filip, M	2
Cunningham, KA; Filip, M; McCreary, AC	1
Alves, SH; Cruz, AP; Landeira-Fernandez, J; Motta, V; Pinheiro, G	1
Goto, F; Obata, H; Saito, S; Sakurazawa, S; Sasaki, M; Usui, T	1
Mellerup, E; Nedergaard, P; Sanchez, C	1
Bubar, MJ; Cunningham, KA; Filip, M	1
Batman, AM; Beardsley, PM; Munzar, P	1
Aguirre, N; Goñi-Allo, B; Ramos, M	1
Hochman, S; Machacek, DW; Sawchuk, M; Shay, BL	1
Cunningham, KA; Frankel, PS; Herin, DV; Ross, JD; Thomas, ML	1
Alves, SH; de Mello Cruz, AP; Faria, L; Ferreira, G; Landeira-Fernandez, J; Macedo, CE; Mendes, M; Motta, V; Pinheiro, G	1
Brown, EK; Hass, RW; Kohut, SJ; Lefever, T; Prabandham, A; Walker, EA	1
Salchner, P; Singewald, N	1
Hurley, LM	1
Amstislavskaya, TG; Bulygina, VV; Kuznetsova, EG; Popova, NK; Tibeikina, MA	1
Goto, F; Ito, N; Obata, H; Saito, S; Sasaki, M	1
Bernard, JF; Comet, MA; Hamon, M; Laguzzi, R; Sévoz-Couche, C	1
Acosta, JI; Neisewander, JL	1
Kozhemiakina, RV; Naumenko, VS; Pliusnina, IZ; Popova, NK	1
Abbas, AI; Arbuckle, MI; Caron, MG; Grant, SG; Roth, BL; Yadav, PN; Yao, WD	1
Fletcher, PJ; Higgins, GA; Isaac, M; Sinyard, J; Slassi, A; Tampakeras, M	1
Gomes, KS; Nunes-De-Souza, RL	1
Cunningham, KA; dela Cruz, AM; Grady, JJ; Herin, DV	1
Foley, JJ; Walker, EA	1
Kozhemyakina, RV; Naumenko, VS; Plyusnina, IZ; Popova, NK	1
Mashimo, T; Nakae, A; Nakai, K; Oba, S; Ueda, K	1
Duke, FD; Hamilton, EC; Neisewander, JL; Pentkowski, NS; Pockros, LA; Teer, AP; Thiel, KJ; Weber, SM	1
Farrell, M; Rosenzweig-Lipson, S; Walker, E	1
Deuchars, J; Deuchars, SA; Pierce, ML	1
Vicente, MA; Zangrossi, H	2
Conway, SM; Neisewander, JL; Pentkowski, NS; Pockros, LA; Ullman, TE; Zwick, KR	1
Appleyard, SM; Cui, RJ; Roberts, BL; Zhao, H; Zhu, M	1
Cunningham, KA; Graves, SM; Napier, TC; Viskniskki, AA	1
Chen, W; Li, M; Qiao, J; Su, W; Sui, N; Yang, Y; Zhang, H; Zhang, Q	1
Bègue, L; Bell, R; Duke, AA; Gilmore, PE; Page, D	1
Mallmann, ES; Paixão, L; Ribeiro, MF; Spritzer, PM	1
Jayathilake, K; Lee, MA; Meltzer, HY; Sim, MY	1
Bazovkina, DV; Kondaurova, EM; Naumenko, VS; Ponimaskin, E	1
Aldegunde, M; Mancebo, MJ; Otero-Rodiño, C; Pérez-Maceira, JJ; Soengas, JL	1
Canto-de-Souza, A; Furuya-da-Cunha, EM; Souza, RR	1
Chen, W; Li, H; Li, M; Wang, X; Wang, Y; Xie, S; Yan, M	1
Burgdorf, J; Cearley, C; Gross, AL; Houck, DR; Khan, MA; Kroes, RA; Madsen, TM; Moskal, JR; Stanton, PK; Zhang, XL	1
Aizawa, H; Ito, Y; Mitani, A; Shimizu, T; Soma, M; Sugimoto, J; Sugiyama, K; Tanaka, K; Tanaka, M	1
Bokhan, NA; Bosker, FJ; Dröge, MJ; Ivanova, SA; Loonen, AJM; van Vliet, BJ; Volders, HH	1
Baptista-de-Souza, D; Canto-de-Souza, A; Canto-de-Souza, L; Nunes-de-Souza, RL; Pelarin, V	1
Heffley, W; Hughes, MA; Hull, C; Joshua, M; McKinney, A; Song, EY; Taylor, BN; Xu, Z	1
de Andrade, TGCS; Hernandes, PM; Sant'Ana, AB; Vicente, MA; Vilela-Costa, HH; Zangrossi, H	1
Arenas, MC; Manzanedo, C; Mateos-García, A; Miñarro, J	1
Chen, W; Guo, G; Ou, H; Shi, M; Tang, J; Yang, C	1

Reviews

2 review(s) available for pyrazines and 6-chloro-2-(1-piperazinyl)pyrazine

Article	Year
The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacologic challenge studies. The Journal of clinical psychiatry, 1992, Volume: 53 Suppl Topics: Biomarkers; Clomipramine; Humans; Neurotransmitter Uptake Inhibitors; Obsessive-Compulsive Disorder; Piperazines; Pyrazines; Pyrimidines; Serotonin	1992
Role of serotonin in obsessive-compulsive disorder. The British journal of psychiatry. Supplement, 1998, Issue:35 Topics: Biogenic Monoamines; Fenfluramine; Humans; Neuropeptides; Obsessive-Compulsive Disorder; Piperazines; Pyrazines; Pyrimidines; Serotonin; Serotonin Syndrome; Synaptic Transmission; Tryptophan	1998

Trials

8 trial(s) available for pyrazines and 6-chloro-2-(1-piperazinyl)pyrazine

Article	Year
Update of the serotonergic hypothesis of obsessive compulsive disorder. Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A Topics: Double-Blind Method; Humans; Obsessive-Compulsive Disorder; Piperazines; Pyrazines; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Antagonists	1992
Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biological psychiatry, 1992, Mar-01, Volume: 31, Issue:5 Topics: Adult; Body Temperature Regulation; Female; Humans; Male; Psychiatric Status Rating Scales; Pyrazines; Receptors, Serotonin; Schizophrenia; Schizophrenic Psychology; Single-Blind Method	1992
Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder. Archives of general psychiatry, 1990, Volume: 47, Issue:9 Topics: Administration, Oral; Adult; Clinical Trials as Topic; Female; Humans; Hydrocortisone; Male; Middle Aged; Obsessive-Compulsive Disorder; Prolactin; Pyrazines; Receptors, Serotonin; Serotonin	1990
Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist. Biological psychiatry, 1988, Apr-15, Volume: 23, Issue:8 Topics: Adult; Dose-Response Relationship, Drug; Growth Hormone; Humans; Hydrocortisone; Male; Prolactin; Pyrazines; Radioimmunoassay	1988
Effect of pindolol pretreatment on MK-212-induced plasma cortisol and prolactin responses in normal men. Biological psychiatry, 1995, Sep-01, Volume: 38, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Humans; Hydrocortisone; Male; Pindolol; Premedication; Prolactin; Pyrazines; Receptors, Serotonin; Reference Values; Serotonin Receptor Agonists	1995
The effect of apomorphine, MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine) and placebo on smooth pursuit gain and corrective saccades in normal subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1994, Volume: 11, Issue:1 Topics: Adult; Apomorphine; Female; Humans; Male; Pursuit, Smooth; Pyrazines; Reference Values; Saccades; Serotonin Receptor Agonists	1994
Blunted oral body temperature response to MK-212 in cocaine addicts. Drug and alcohol dependence, 1994, Volume: 35, Issue:3 Topics: Adult; Body Temperature Regulation; Cocaine; Humans; Hydrocortisone; Male; Prolactin; Pyrazines; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Substance-Related Disorders	1994
Effect of the placebo control condition in neuroendocrine challenge studies. Psychiatry research, 1994, Volume: 52, Issue:3 Topics: 5-Hydroxytryptophan; Antipsychotic Agents; Apomorphine; Bias; Buspirone; Data Interpretation, Statistical; Depressive Disorder; Female; Fenfluramine; Growth Hormone; Humans; Hydrocortisone; Male; Prolactin; Pyrazines; Schizophrenia; Schizophrenic Psychology; Serotonin Receptor Agonists	1994

Other Studies

131 other study(ies) available for pyrazines and 6-chloro-2-(1-piperazinyl)pyrazine

Article	Year
Central serotonergic agents raise the repetitive extrasystole threshold of the vulnerable period of the canine ventricular myocardium. Circulation research, 1979, Volume: 44, Issue:5 Topics: Animals; Blood Pressure; Cardiac Complexes, Premature; Dogs; Ethanol; Female; Heart Rate; Heart Ventricles; Indoles; Male; Melatonin; Piperazines; Pyrazines; Serotonin; Time Factors; Vagotomy	1979
Rapid, sensitive and specific electron capture-gas chromatographic method for the quantitation of 6-chloro-2-(1-piperazinyl) pyrazine in biological fluids. Journal of chromatography, 1979, Jan-01, Volume: 162, Issue:1 Topics: Animals; Chromatography, Gas; Dogs; Haplorhini; Macaca mulatta; Male; Mass Spectrometry; Methods; Piperazines; Pyrazines; Rats; Receptors, Serotonin	1979
Pharmacological differentiation of the central 5-hydroxytryptamine-like actions of MK-212 (6-chloro-2[1-piperazinyl]-pyrazine),p-methoxyamphetamine and fenfluramine in an in vivo model system. European journal of pharmacology, 1978, Aug-15, Volume: 50, Issue:4 Topics: Amphetamines; Animals; Dextroamphetamine; Drug Interactions; Fenclonine; Fenfluramine; Fluoxetine; In Vitro Techniques; Male; Metergoline; Muscle Contraction; Piperazines; Pyrazines; Rats; Serotonin; Time Factors	1978
Anorexigenic and ancillary actions of MK-212 (6-chloro-2-(1-piperazinyl)-pyrazine; CPP). Psychopharmacology, 1977, Nov-24, Volume: 55, Issue:1 Topics: Animals; Appetite Depressants; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Eating; Female; Fenfluramine; Male; Metergoline; Motor Activity; Piperazines; Pyrazines; Rats; Self Administration	1977
MK-212: a serotonin-like agonist in the CNS. General pharmacology, 1979, Volume: 10, Issue:4 Topics: Animals; Appetite Depressants; Behavior, Animal; Catecholamines; Central Nervous System; Female; Piperazines; Pyrazines; Rats; Receptors, Serotonin; Serotonin; Uterine Contraction	1979
A 5-hydroxytryptamine-like mode of anorectic action for 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212). British journal of pharmacology, 1978, Volume: 62, Issue:4 Topics: 5,6-Dihydroxytryptamine; Animals; Appetite Depressants; Clomipramine; Female; Haloperidol; p-Chloroamphetamine; Piperazines; Pyrazines; Raphe Nuclei; Rats; Serotonin; Serotonin Antagonists	1978
Inhibition of the serotoninergic uptake system by MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine) Pharmacological research communications, 1978, Volume: 10, Issue:3 Topics: Animals; Cerebral Cortex; Clomipramine; Depression, Chemical; Desipramine; Dopamine; Female; In Vitro Techniques; Neurons; Norepinephrine; p-Chloroamphetamine; Piperazines; Pyrazines; Rats; Serotonin	1978
Central serotonin-like activity of 6-chloro-2-[1-piperazinyl]-pyrazine (CPP; MK-212). European journal of pharmacology, 1977, Jul-01, Volume: 44, Issue:1 Topics: Animals; Behavior, Animal; Electric Stimulation; Female; Male; Motor Activity; Muscle Contraction; Piperazines; Pyrazines; Rats; Reflex; Serotonin; Serotonin Antagonists; Time Factors	1977
Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212. Biological psychiatry, 1992, Aug-01, Volume: 32, Issue:3 Topics: Adrenocorticotropic Hormone; Animals; Arousal; Brain; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Hormones; Injections, Intraperitoneal; Male; Neurosecretory Systems; Oxytocin; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Renin; Synaptic Transmission; Vasopressins	1992
Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI. European journal of pharmacology, 1992, Oct-06, Volume: 221, Issue:1 Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Cocaine; Corticosterone; Hormones; Male; Oxytocin; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Renin; Serotonin Receptor Agonists	1992
Brain serotoninergic stimulation reduces the water intake induced by systemic and central beta-adrenergic administration. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1992, Volume: 25, Issue:5 Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Brain; Drinking; Isoproterenol; Male; Pyrazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Stimulation, Chemical; Time Factors	1992
Thyroidectomy blocks stress-induced prolactin rise in rats: role of the central serotonergic system. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1992, Volume: 24, Issue:10 Topics: Animals; Central Nervous System; Ergolines; Kinetics; Male; Prolactin; Pyrazines; Radioimmunoassay; Rats; Rats, Wistar; Restraint, Physical; Serotonin; Serotonin Antagonists; Stress, Psychological; Thyroidectomy; Time Factors	1992
In vivo effects of serotonergic agents on alpha-melanocyte-stimulating hormone secretion. Neuroendocrinology, 1991, Volume: 54, Issue:6 Topics: alpha-MSH; Animals; Apomorphine; beta-Endorphin; Chromatography, High Pressure Liquid; Cytoplasmic Granules; Male; Pituitary Gland; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin	1991
Neuroendocrine responses to serotonergic agents in alcoholics. Biological psychiatry, 1991, Nov-15, Volume: 30, Issue:10 Topics: 5-Hydroxytryptophan; Adult; Alcoholism; Arousal; Brain; Growth Hormone; Hospitalization; Humans; Hydrocortisone; Male; Middle Aged; Prolactin; Pyrazines; Receptors, Serotonin; Serotonin	1991
Differential effects of novel ligands for 5-HT receptor subtypes on nonopioid defensive analgesia in male mice. Neuroscience and biobehavioral reviews, 1991,Winter, Volume: 15, Issue:4 Topics: Aggression; Analgesia; Animals; Dioxins; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred DBA; Pyrazines; Quinolines; Quinoxalines; Reaction Time; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Spiro Compounds	1991
Attenuation of 5-HT1A and 5-HT2 but not 5-HT1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants. Psychopharmacology, 1991, Volume: 105, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Male; Mianserin; Penile Erection; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes; Tranylcypromine	1991
Thyroidectomy reduces stress-induced prolactin secretion in rats. Participation of brain serotonergic systems. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1990, Volume: 23, Issue:8 Topics: Animals; Brain Chemistry; Male; Prolactin; Pyrazines; Rats; Receptors, Serotonin; Stress, Physiological; Thyroidectomy	1990
Central serotonergic modulation of drinking behavior induced by water deprivation: effect of a serotonergic agonist (MK-212) administered intracerebroventricularly. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1990, Volume: 23, Issue:12 Topics: Animals; Drinking Behavior; Hypothalamus; Injections, Intraventricular; Male; Pyrazines; Rats; Receptors, Serotonin; Serotonin; Water Deprivation	1990
Central serotonergic modulation of drinking behavior induced by angiotensin II and carbachol in normally hydrated rats: effect of intracerebroventricular injection of MK-212. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1990, Volume: 23, Issue:12 Topics: Angiotensin II; Animals; Carbachol; Drinking Behavior; Injections, Intraventricular; Male; Pyrazines; Rats; Serotonin	1990
Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. British journal of pharmacology, 1990, Volume: 101, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Body Temperature; Male; Mice; Mice, Inbred ICR; Motor Activity; Piperazines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1990
5-HT-induced transferrin production by choroid plexus epithelial cells in culture: role of 5-HT1c receptor. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: Animals; Cells, Cultured; Choroid Plexus; Epithelium; Lysergic Acid Diethylamide; Male; Phosphatidylinositols; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Transferrin	1990
Effects of serotonin agonists on operant behavior in the squirrel monkey: quipazine, MK-212, trifluoromethylphenylpiperazine, and chlorophenylpiperazine. Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:1 Topics: Animals; Conditioning, Operant; Male; Piperazines; Pyrazines; Quipazine; Receptors, Serotonin; Saimiri; Serotonin Antagonists	1990
Pharmacological characterization of 5-hydroxytryptamine2 and 5-hydroxytryptamine3 receptors in rat dorsal root ganglion cells. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Ganglia, Spinal; Indoles; Ketanserin; Male; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tropanes; Tropisetron	1990
Selective reduction by serotonergic agents of hypertonic saline consumption in rats: evidence for possible 5-HT1C receptor mediation. Psychopharmacology, 1989, Volume: 99, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Fenfluramine; Fluoxetine; Hypertonic Solutions; Indoles; Male; Piperazines; Pyrazines; Quinoxalines; Quipazine; Rats; Receptors, Serotonin; Serotonin	1989
Effect of selective serotonin (5-HT) agonists and 5-HT2 antagonist on prolactin secretion. Neuropharmacology, 1989, Volume: 28, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Ergolines; Fenfluramine; Indoles; Male; Prolactin; Pyrazines; Radioimmunoassay; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1989
Selective cross-tolerance to 5-HT1A and 5-HT2 receptor-mediated temperature and corticosterone responses. Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Body Temperature Regulation; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Male; Methoxydimethyltryptamines; Naphthalenes; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes; Tryptamines	1989
MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype. Neuroscience letters, 1989, Oct-23, Volume: 105, Issue:1-2 Topics: Adrenocorticotropic Hormone; Animals; Antiparkinson Agents; Ergolines; Ketanserin; Male; Metergoline; Pindolol; Piperazines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone	1989
Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Electric Stimulation; Haloperidol; Male; Methoxydimethyltryptamines; Methyltyrosines; Prolactin; Pyrazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tetrahydronaphthalenes	1989
Participation of the serotonergic system in the regulation of water and electrolyte balance. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1989, Volume: 22, Issue:6 Topics: Animals; Injections, Intraventricular; Microinjections; Potassium; Pyrazines; Rats; Rats, Inbred Strains; Sodium; Water; Water-Electrolyte Balance	1989
Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:1 Topics: Animals; Antidepressive Agents; Behavior, Animal; Male; Monoamine Oxidase Inhibitors; Motor Activity; Piperazines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin	1989
Apparent antinociceptive properties of piperazine-type serotonin agonists: trifluoromethylphenylpiperazine, chlorophenylpiperazine, and MK-212. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:3 Topics: Animals; Dose-Response Relationship, Drug; Male; Methysergide; Nociceptors; Piperazines; Pyrazines; Receptors, Serotonin; Saimiri	1989
Effects of brain histamine depletion on stimulated prolactin release in rats. Agents and actions, 1989, Volume: 27, Issue:1-2 Topics: Animals; Brain; Histamine; Male; Methylhistidines; Morphine; Prolactin; Pyrazines; Rats; Rats, Inbred Strains	1989
Hypothermic effects of MK-212, a 5-hydroxytryptaminergic stimulant, in normotensive Wistar-Kyoto and spontaneously hypertensive rats. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:1 Topics: Animals; Body Temperature; Female; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity	1986
Behavioral studies with anxiolytic drugs. IV. Serotonergic involvement in the effects of buspirone on punished behavior of pigeons. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Columbidae; Dose-Response Relationship, Drug; Ketanserin; Male; Punishment; Pyrazines; Pyrimidines; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes; Tritium	1987
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat. European journal of pharmacology, 1988, Jul-14, Volume: 151, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Body Temperature; Butyrophenones; Chlorpromazine; Clozapine; Corticosterone; Haloperidol; Male; Neurosecretory Systems; Pyrazines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1988
Effects of serotonin receptor agonists and antagonists on schedule-controlled behavior of squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2 Topics: 5-Hydroxytryptophan; Animals; Cinanserin; Conditioning, Operant; Cyproheptadine; Electroshock; Female; Ketanserin; Male; Metergoline; Methysergide; Piperazines; Piperidines; Pyrazines; Quipazine; Receptors, Serotonin; Saimiri	1985
Characterization of 5-hydroxytryptamine receptors in rat stomach fundus. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3 Topics: Animals; Binding, Competitive; Brain Chemistry; Gastric Fundus; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Piperazines; Piperidines; Propranolol; Pyrazines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tritium	1985
Effects of MK-212 (6-chloro-2[1-piperazinyl]pyrazine) on schedule-controlled behavior and their reversal by 5-HT antagonists in the pigeon. Neuropharmacology, 1986, Volume: 25, Issue:1 Topics: Animals; Columbidae; Conditioning, Operant; Cues; Generalization, Stimulus; Ketanserin; Male; Metergoline; Methysergide; Piperidines; Pyrazines; Receptors, Serotonin; Reinforcement Schedule	1986
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors. Neuropharmacology, 1986, Volume: 25, Issue:12 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature Regulation; Ketanserin; Male; Methoxydimethyltryptamines; Pindolol; Piperidines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes	1986
Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology, 1987, Volume: 45, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Corticosterone; Ergolines; Fenfluramine; Male; Pyrazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Renin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1987
Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation. European journal of pharmacology, 1987, May-07, Volume: 137, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; beta-Endorphin; Corticosterone; Endorphins; Ketanserin; Male; Pindolol; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes	1987
Selective desensitization of serotonin (5-HT) receptor-mediated hyperthermia by mianserin and other 5-HT antagonists. Neuropharmacology, 1987, Volume: 26, Issue:7A Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dose-Response Relationship, Drug; Fever; Male; Mianserin; Pyrazines; Rats; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1987
Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Blood Pressure; Cats; Heart Rate; Piperazines; Pyrazines; Receptors, Serotonin; Serotonin Antagonists; Sympathetic Nervous System; Tetrahydronaphthalenes	1987
Molecular target size of NMDA antagonist binding sites. European journal of pharmacology, 1987, Apr-07, Volume: 136, Issue:1 Topics: Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Ligands; Molecular Weight; N-Methylaspartate; Phencyclidine; Pyrazines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1987
Discriminative stimulus properties of the serotonin agonist MK 212. Psychopharmacology, 1986, Volume: 90, Issue:2 Topics: Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Pyrazines; Rats; Rats, Inbred Strains; Serotonin	1986
Neuropharmacological characterization of serotoninergic stimulation of vasopressin secretion in conscious rats. Neuroendocrinology, 1988, Volume: 47, Issue:4 Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Ergolines; Hypothalamic Area, Lateral; Male; p-Chloroamphetamine; Pyrazines; Radioimmunoassay; Rats; Receptors, Serotonin; Serotonin; Vasopressins	1988
Local cerebral glucose utilisation following indoleamine- and piperazine-containing 5-hydroxytryptamine agonists. Journal of neurochemistry, 1986, Volume: 46, Issue:1 Topics: Animals; Autoradiography; Behavior, Animal; Brain; Deoxyglucose; Glucose; Guinea Pigs; Lysergic Acid Diethylamide; Male; Methoxydimethyltryptamines; Pyrazines; Quinolines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin	1986
Bioactive conformation of 1-arylpiperazines at central serotonin receptors. Journal of medicinal chemistry, 1985, Volume: 28, Issue:7 Topics: Animals; Central Nervous System; Chemical Phenomena; Chemistry; Female; Frontal Lobe; Mice; Molecular Conformation; Piperazines; Posture; Pyrazines; Quinolines; Rats; Receptors, Serotonin; Serotonin; Spiperone; Structure-Activity Relationship	1985
Serotonergic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain of mice. European journal of pharmacology, 1981, Jul-17, Volume: 73, Issue:2-3 Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Male; Mice; Muscimol; Myoclonus; Oxazoles; Piperazines; Pyrazines; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Serotonin; Serotonin	1981
Naloxone and naltrexone block the gastrointestinal effects of TRH and MK-212. Proceedings of the Western Pharmacology Society, 1984, Volume: 27 Topics: Animals; Digestive System; Male; Naloxone; Naltrexone; Pyrazines; Rabbits; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone	1984
The ability of certain anorexic drugs to suppress food consumption depends on the nutrient composition of the test diet. Life sciences, 1984, Sep-17, Volume: 35, Issue:12 Topics: Animals; Appetite Depressants; Benzphetamine; Chlorphentermine; Dextroamphetamine; Dietary Carbohydrates; Eating; Fenfluramine; Male; Pyrazines; Rats; Rats, Inbred Strains; Serotonin	1984
A comparative electrophysiological and biochemical assessment of serotonin (5-HT) and a novel 5-HT agonist (MK-212) on central serotonergic receptors. Neuropharmacology, 1984, Volume: 23, Issue:11 Topics: Action Potentials; Animals; Brain Chemistry; Electrophysiology; Female; Hypothalamus; Lysergic Acid Diethylamide; Methiothepin; Neurons; Potassium Chloride; Pyrazines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin	1984
A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine. Psychopharmacology, 1981, Volume: 73, Issue:2 Topics: Animals; Cocaine; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Hallucinogens; Lisuride; Lysergic Acid Diethylamide; Male; p-Chloroamphetamine; Piperazines; Pyrazines; Quipazine; Rats; Serotonin; Serotonin Antagonists	1981
A comparison of the analgesic activities of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) and 6-chloro-2[1-piperazinyl]pyrazine (MK 212). European journal of pharmacology, 1983, Jun-03, Volume: 90, Issue:2-3 Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Oxazoles; Pyrazines; Time Factors	1983
Serotonin-like actions of quipazine and CPP on spinal motoneurones. European journal of pharmacology, 1982, Jun-16, Volume: 81, Issue:1 Topics: 5,7-Dihydroxytryptamine; Animals; Glutamates; Male; Metergoline; Methysergide; Motor Neurons; p-Chloroamphetamine; Pyrazines; Quinolines; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord	1982
Differences among 'serotonergic' anorectics in a cross-tolerance paradigm: do they all act on serotonin systems? European journal of pharmacology, 1982, Jun-16, Volume: 81, Issue:1 Topics: Animals; Appetite Depressants; Body Weight; Drug Tolerance; Fenfluramine; Male; Pyrazines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin	1982
Modification of apomorphine hypothermia by drugs affecting brain 5-hydroxytryptamine function. European journal of pharmacology, 1981, Dec-03, Volume: 76, Issue:2-3 Topics: Animals; Apomorphine; Body Temperature; Brain; Hypothermia; Lysergic Acid Diethylamide; Male; Mice; Mice, Inbred Strains; Piperazines; Pyrazines; Quipazine; Receptors, Serotonin; Serotonin Antagonists	1981
L-Tryptophan injection enhances pulsatile growth hormone secretion in the rat. Endocrinology, 1981, Volume: 108, Issue:1 Topics: Animals; Brain Chemistry; Growth Hormone; Male; Piperazines; Pituitary Gland; Pyrazines; Rats; Receptors, Serotonin; Serotonin; Tryptophan; Valine	1981
Reduced prolactin release during immobilization stress in thyrotoxic rats: role of the central serotoninergic system. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1995, Volume: 27, Issue:3 Topics: Animals; Ergolines; Immobilization; Male; Prolactin; Pyrazines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stress, Psychological; Thyrotoxicosis; Thyrotropin; Thyroxine	1995
Comparison of stimulus properties of fluoxetine and 5-HT receptor agonists in a conditioned taste aversion procedure. European journal of pharmacology, 1994, Feb-21, Volume: 253, Issue:1-2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Avoidance Learning; Conditioning, Classical; Fluoxetine; Male; Mice; Paroxetine; Pyrazines; Serotonin Receptor Agonists; Taste	1994
Involvement of the 5-HT2 receptor in the 5-HT receptor-mediated stimulation of prolactin release. European journal of pharmacology, 1994, Jan-14, Volume: 251, Issue:2-3 Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Drug Interactions; Male; Piperazines; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists	1994
Effect of selective serotonin receptor agonists on prolactin secretion in male rats. Neuroendocrinology, 1993, Volume: 57, Issue:3 Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Indoles; Male; Prolactin; Pyrazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists	1993
Effects of d-fenfluramine, MK-212, and ondansetron on saline drinking in two-choice tests in the rehydrating rat. Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:3 Topics: Animals; Drinking Behavior; Fenfluramine; Isotonic Solutions; Male; Ondansetron; Pyrazines; Rats; Saline Solution, Hypertonic; Serotonin Receptor Agonists; Sodium Chloride; Taste; Water Deprivation	1993
Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI). The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2 Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Desipramine; Drug Synergism; Fluoxetine; Hormones; Ketanserin; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Vasopressins	1993
Discriminative stimulus properties of m-chlorophenylpiperazine. Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:1 Topics: Animals; Discrimination Learning; Generalization, Stimulus; Indoles; Male; Piperazines; Pyrazines; Rats; Rats, Inbred F344; Serotonin Antagonists; Serotonin Receptor Agonists	1993
5-HT2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology, 1995, Volume: 122, Issue:3 Topics: Animals; Choroid Plexus; Conditioning, Operant; DOM 2,5-Dimethoxy-4-Methylamphetamine; Drug Interactions; Ketanserin; Lysergic Acid Diethylamide; Ondansetron; Phosphatidylinositols; Piperazines; Pyrazines; Quipazine; Rats; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists	1995
Modulation of 5-HT receptor subtype-mediated behaviours by corticosterone. European journal of pharmacology, 1996, Jul-18, Volume: 308, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Corticosterone; Locomotion; Male; Pyrazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists	1996
Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212. European journal of pharmacology, 1996, Sep-12, Volume: 311, Issue:2-3 Topics: Animals; Corticosterone; Fluorobenzenes; Indoles; Male; Piperidines; Pyrazines; Quipazine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Urea	1996
The 5-HT2 receptor agonist MK-212 reduces food intake and increases resting but prevents the behavioural satiety sequence. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:1 Topics: Animals; Eating; Feeding Behavior; Grooming; Male; Motor Activity; Pyrazines; Rats; Satiety Response; Serotonin Receptor Agonists; Time Factors	1997
Enhancement of dopamine-mediated behaviour by the NMDA antagonists MK-801 and CPP: similarities with repeated electroconvulsive shock. Psychopharmacology, 1997, Volume: 133, Issue:1 Topics: Animals; Dizocilpine Maleate; Dopamine Agonists; Electroshock; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Motor Activity; Nucleus Accumbens; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1997
Indirect in vivo 5-HT1A-agonistic effects of the new antidepressant mirtazapine. Psychopharmacology, 1997, Volume: 133, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Conditioning, Operant; Fluoxetine; Male; Mianserin; Mice; Mice, Inbred ICR; Mirtazapine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Taste	1997
Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens. Brain research, 1998, Jan-19, Volume: 781, Issue:1-2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Microdialysis; Morphine; Narcotic Antagonists; Nucleus Accumbens; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists	1998
[Effects of serotonergic drugs on the up-regulation of dopamine D2 receptors induced by haloperidol in rat striatum]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1998, Volume: 73, Issue:5 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Dyskinesia Agents; Antipsychotic Agents; Citalopram; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Pyrazines; Rats; Rats, Wistar; Receptors, Dopamine D2; Ritanserin; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Up-Regulation	1998
Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO 60-0175: a pharmacological analysis. Neuropharmacology, 1999, Volume: 38, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Conditioning, Operant; Ethylamines; Fluorobenzenes; Indoles; Male; Mianserin; Piperazines; Piperidines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes	1999
Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions. Psychopharmacology, 1999, Volume: 146, Issue:3 Topics: Animals; Cocaine; Male; Mice; Mice, Inbred C57BL; Piperazines; Pyrazines; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Seizures; Species Specificity	1999
Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin(2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse (New York, N.Y.), 2000, Volume: 35, Issue:1 Topics: Aminopyridines; Animals; Dopamine; Indoles; Male; Neostriatum; Neurons; Nucleus Accumbens; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substantia Nigra; Ventral Tegmental Area	2000
Inhibition of rat nucleus tractus solitarius neurones by activation of 5-HT2C receptors. Neuroreport, 2000, Jun-05, Volume: 11, Issue:8 Topics: Amphetamines; Animals; Evoked Potentials; Ligands; Male; Neural Inhibition; Neurons; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Solitary Nucleus; Spiro Compounds; Sulfonamides; Vagus Nerve	2000
In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine(2) receptors in rats. British journal of pharmacology, 2000, Volume: 131, Issue:7 Topics: Afferent Pathways; Amphetamines; Animals; Antihypertensive Agents; Electric Conductivity; Evoked Potentials; Heart; Indoles; Lung; Male; Medulla Oblongata; Nerve Fibers, Myelinated; Neurons; Organic Chemicals; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Solitary Nucleus; Spiro Compounds; Sulfonamides; Thiophenes; Vagus Nerve	2000
In-vivo assessment of 5-HT2A and 5-HT2C antagonistic properties of newer antipsychotics. Behavioural pharmacology, 2000, Volume: 11, Issue:3-4 Topics: Animals; Antipsychotic Agents; Head; Ligands; Male; Movement; Pyrazines; Quipazine; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists	2000
Serotonin(2) receptors mediate respiratory recovery after cervical spinal cord hemisection in adult rats. Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 91, Issue:6 Topics: Amphetamines; Animals; Asphyxia; Cervical Vertebrae; Female; Ketanserin; Phrenic Nerve; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reference Values; Respiratory Physiological Phenomena; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord Injuries; Spiro Compounds; Sulfonamides	2001
Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacology, biochemistry, and behavior, 2002, Volume: 71, Issue:4 Topics: Animals; Cocaine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylamines; Hyperkinesis; Indoles; Male; Microinjections; Motor Activity; Nucleus Accumbens; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides	2002
Discriminative stimulus properties of (+/-)-fenfluramine: the role of 5-HT2 receptor subtypes. Behavioral neuroscience, 2003, Volume: 117, Issue:2 Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Fenfluramine; Fluorobenzenes; Indoles; Ketanserin; Male; Piperidines; Pyrazines; Pyridines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides; Thiophenes	2003
Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2 Topics: Animals; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Microinjections; Motor Activity; Prefrontal Cortex; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride; Spiro Compounds; Sulfonamides	2003
Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but not dorsal hippocampus. Behavioural pharmacology, 2004, Volume: 15, Issue:1 Topics: Animals; Arousal; Brain Mapping; Dose-Response Relationship, Drug; Fear; Hippocampus; Male; Maze Learning; Microinjections; Piperazines; Pyrazines; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists	2004
Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury. Pain, 2004, Volume: 108, Issue:1-2 Topics: Amphetamines; Animals; Indoles; Injections, Spinal; Ketanserin; Ligation; Lumbar Vertebrae; Male; Neuralgia; Nociceptors; Piperazines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Nerves; Spiro Compounds; Sulfonamides; Thiophenes	2004
Different roles of 5-HT2A and 5-HT2C receptors in regulation of female rat paced mating behaviour. Behavioural brain research, 2004, Mar-02, Volume: 149, Issue:2 Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Estradiol; Female; Male; Motivation; Progesterone; Pyrazines; Rats; Rats, Wistar; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Sexual Behavior, Animal; Statistics, Nonparametric	2004
Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3 Topics: Amphetamines; Animals; Cocaine; Drug Interactions; Fluorobenzenes; Hyperkinesis; Indoles; Male; Phenols; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes	2004
Attenuation of nicotine's discriminative stimulus effects in rats and its locomotor activity effects in mice by serotonergic 5-HT2A/2C receptor agonists. Psychopharmacology, 2005, Volume: 179, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Conditioning, Operant; Discrimination, Psychological; Excitatory Amino Acid Antagonists; Indophenol; Ketamine; Male; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists	2005
Administration of SCH 23390 into the medial prefrontal cortex blocks the expression of MDMA-induced behavioral sensitization in rats: an effect mediated by 5-HT2C receptor stimulation and not by D1 receptor blockade. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:12 Topics: Animals; Behavior, Animal; Benzazepines; Dopamine Antagonists; Hallucinogens; Male; Microinjections; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Prefrontal Cortex; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D1; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides	2005
Serotonin 5-HT2 receptors induce a long-lasting facilitation of spinal reflexes independent of ionotropic receptor activity. Journal of neurophysiology, 2005, Volume: 94, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Animals, Newborn; Clozapine; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Female; Ganglia, Spinal; Immunohistochemistry; In Vitro Techniques; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT2; Reflex; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Time Factors	2005
Chronic treatment with a serotonin(2) receptor (5-HT(2)R) agonist modulates the behavioral and cellular response to (+)-3,4-methylenedioxymethamphetamine [(+)-MDMA]. Drug and alcohol dependence, 2006, Feb-01, Volume: 81, Issue:2 Topics: Amphetamines; Analysis of Variance; Animals; Behavior, Animal; Down-Regulation; Hallucinogens; Humans; Immunohistochemistry; Male; N-Methyl-3,4-methylenedioxyamphetamine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT2; Serotonin 5-HT2 Receptor Agonists; Serotonin Agents; Serotonin Receptor Agonists	2006
Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology, 2005, Volume: 182, Issue:3 Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Male; Maze Learning; Motor Activity; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists	2005
Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice. Neuropharmacology, 2005, Volume: 49, Issue:8 Topics: Animals; Avoidance Learning; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Lithium Chloride; Lysergic Acid Diethylamide; Male; Mianserin; Mice; Piperazines; Pyrazines; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Serotonin Antagonists; Taste	2005
5-HT receptor subtypes involved in the anxiogenic-like action and associated Fos response of acute fluoxetine treatment in rats. Psychopharmacology, 2006, Volume: 185, Issue:3 Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Fluoxetine; Indoles; Locus Coeruleus; Male; Oxazines; Piperazines; Piperidones; Proto-Oncogene Proteins c-fos; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds	2006
Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus. Journal of neurophysiology, 2006, Volume: 96, Issue:5 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Chiroptera; Dose-Response Relationship, Drug; Electrodes; Electrophysiology; Evoked Potentials, Auditory; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Inferior Colliculi; Iontophoresis; Male; Pyrazines; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Receptor Agonists	2006
Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:5 Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression, Chemical; Male; Mice; Mice, Inbred CBA; Motor Activity; Pyrazines; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists	2006
Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury. European journal of pharmacology, 2007, Jul-12, Volume: 567, Issue:1-2 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Atropine; Injections, Spinal; Ligation; Male; Muscarinic Antagonists; Norepinephrine; Pain; Peripheral Nervous System Diseases; Physical Stimulation; Piperazines; Pyrazines; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Agonists; Spinal Cord; Spinal Nerves; Touch; Yohimbine	2007
Activation of nucleus tractus solitarius 5-HT2A but not other 5-HT2 receptor subtypes inhibits the sympathetic activity in rats. The European journal of neuroscience, 2007, Volume: 26, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Atropine Derivatives; Baroreflex; Blood Pressure; Heart Rate; Indoles; Male; Microinjections; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin Receptor Agonists; Solitary Nucleus; Sympathetic Nervous System; Thiophenes	2007
Stimulation of 5-HT2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats. Behavioural pharmacology, 2007, Volume: 18, Issue:8 Topics: Aminopyridines; Animals; Behavior, Addictive; Cocaine; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Indoles; Male; Motor Activity; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Self Administration	2007
[Functional correlates of the brain 5-HT2A and 5-HT2C serotonin receptors and expression of 5-HT2A AND 5-HT2C genes in aggressive and nonaggressive Norway rats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2009, Volume: 95, Issue:2 Topics: Aggression; Amphetamines; Animals; Behavior, Animal; Frontal Lobe; Gene Expression Regulation; Hypothalamus; Male; Nerve Tissue Proteins; Pyrazines; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists	2009
PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jun-03, Volume: 29, Issue:22 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Animals, Newborn; Antipsychotic Agents; Cerebral Cortex; Disks Large Homolog 4 Protein; Gene Expression Regulation; Green Fluorescent Proteins; Guanylate Kinases; Hallucinogens; Hypothermia; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Mice, Knockout; Microtubule-Associated Proteins; Neural Inhibition; Neurons; Protein Binding; Protein Transport; Proto-Oncogene Proteins c-fos; Pyrazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Serotonin Receptor Agonists; Transduction, Genetic	2009
Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. Neuropharmacology, 2009, Volume: 57, Issue:3 Topics: Aminopyridines; Animals; Benzazepines; Dexfenfluramine; Eating; Ethylamines; Feeding Behavior; Indoles; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naphthyridines; Piperazines; Pyrazines; Quinoxalines; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists	2009
Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. Progress in neuro-psychopharmacology & biological psychiatry, 2009, Oct-01, Volume: 33, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Microinjections; Motor Activity; Periaqueductal Gray; Pyrazines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Reproducibility of Results; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Serotonin Agents	2009
Novel approach to data analysis in cocaine-conditioned place preference. Behavioural pharmacology, 2009, Volume: 20, Issue:8 Topics: Animals; Benzazepines; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Male; Models, Animal; N-Methyl-3,4-methylenedioxyamphetamine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serotonin Receptor Agonists; Time Factors	2009
Acquisition session length modulates consolidation effects produced by 5-HT2C ligands in a mouse autoshaping-operant procedure. Behavioural pharmacology, 2010, Volume: 21, Issue:2 Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Inverse Agonism; Drug Partial Agonism; Indoles; Ligands; Lysergic Acid Diethylamide; Male; Memory; Methysergide; Mianserin; Mice; Piperazines; Pyrazines; Pyridines; Reinforcement Schedule; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors	2010
Functional characteristics of serotonin 5-HT2A and 5-HT2C receptors in the brain and the expression of the 5-HT2A and 5-HT2C receptor genes in aggressive and non-aggressive rats. Neuroscience and behavioral physiology, 2010, Volume: 40, Issue:4 Topics: Aggression; Amphetamines; Animals; Behavior, Animal; Frontal Lobe; Gene Expression Regulation; Hypothalamus; Male; Nerve Tissue Proteins; Pyrazines; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists	2010
5-HT2C receptor agonists attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain. European journal of pain (London, England), 2010, Volume: 14, Issue:10 Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ethylamines; Indoles; Injections, Spinal; Male; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides; Trigeminal Neuralgia	2010
Stimulation of medial prefrontal cortex serotonin 2C (5-HT(2C)) receptors attenuates cocaine-seeking behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:10 Topics: Aminopyridines; Animals; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Extinction, Psychological; Indoles; Male; Prefrontal Cortex; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Self Administration; Serotonin Antagonists; Serotonin Receptor Agonists	2010
Discriminative stimulus effects of serotonin agonists, neutral antagonists, and inverse agonists in pigeons: perspectives on intrinsic efficacy measurements in vivo. Psychopharmacology, 2010, Volume: 211, Issue:2 Topics: Animals; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Inverse Agonism; Male; Methysergide; Mianserin; Pyrazines; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists	2010
Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice. Neuroscience, 2010, Oct-27, Volume: 170, Issue:3 Topics: Action Potentials; Adrenergic Fibers; Animals; Autonomic Fibers, Preganglionic; Bicuculline; Female; Male; Periodicity; Pyrazines; Rats; Rats, Wistar; Serotonin; Spinal Cord; Tetrodotoxin	2010
Serotonin-2C receptors in the basolateral nucleus of the amygdala mediate the anxiogenic effect of acute imipramine and fluoxetine administration. The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:3 Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety Disorders; Avoidance Learning; Basolateral Nuclear Complex; Exploratory Behavior; Fluoxetine; Imipramine; Indoles; Male; Maze Learning; Neuropsychological Tests; Pyrazines; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists	2012
5-HT(2A) receptor blockade and 5-HT(2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen. Synapse (New York, N.Y.), 2012, Volume: 66, Issue:12 Topics: Animals; Caudate Nucleus; Cocaine; Fluorobenzenes; Gene Expression Regulation; Locomotion; Male; Piperidines; Proto-Oncogene Proteins c-fos; Putamen; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists	2012
Serotonin activates catecholamine neurons in the solitary tract nucleus by increasing spontaneous glutamate inputs. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Nov-14, Volume: 32, Issue:46 Topics: Action Potentials; Animals; Catecholamines; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Mice; Neurons; Patch-Clamp Techniques; Piperazines; Pyrazines; Quinoxalines; Receptors, Presynaptic; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Receptor Agonists; Solitary Nucleus; Tyrosine 3-Monooxygenase	2012
Serotonin(2C) receptors in the ventral pallidum regulate motor function in rats. Neuroreport, 2013, Aug-07, Volume: 24, Issue:11 Topics: Animals; Limbic System; Male; Motor Activity; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists; Synaptic Transmission	2013
Involvement of 5-HT2C and 5-HT1A receptors of the basolateral nucleus of the amygdala in the anxiolytic effect of chronic antidepressant treatment. Neuropharmacology, 2014, Volume: 79 Topics: Amygdala; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety; Avoidance Learning; Exploratory Behavior; Fluoxetine; Imipramine; Male; Maze Learning; Panic; Piperazines; Pyrazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists	2014
Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats. Pharmacology, biochemistry, and behavior, 2014, Volume: 117 Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fluorobenzenes; Piperidines; Postpartum Period; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists	2014
Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands. Scientific reports, 2014, Jan-24, Volume: 4 Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Male; Maze Learning; Oxazines; Piperidines; Propane; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides	2014
Serotonergic 5-HT2A/2C receptors are involved in prolactin secretion in hyperestrogenic rats. Neuroscience letters, 2014, Oct-17, Volume: 582 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Estradiol; Estrogens; Female; Pindolol; Prolactin; Pyrazines; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists	2014
Decreased serotonin2C receptor responses in male patients with schizophrenia. Psychiatry research, 2015, Mar-30, Volume: 226, Issue:1 Topics: Adult; Body Temperature Regulation; Case-Control Studies; Female; Humans; Hydrocortisone; Male; Middle Aged; Psychopathology; Pyrazines; Receptors, Serotonin; Schizophrenia; Schizophrenic Psychology; Serotonin; Serotonin Receptor Agonists; Severity of Illness Index	2015
Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. Neural plasticity, 2015, Volume: 2015 Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Genotype; Head Movements; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Motor Activity; Pyrazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Species Specificity; Spiro Compounds; Sulfonamides	2015
Food intake inhibition in rainbow trout induced by activation of serotonin 5-HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2016, Volume: 186, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Agouti-Related Protein; Animals; Corticotropin-Releasing Hormone; Eating; Fish Proteins; Gene Expression; Hypothalamus; Nerve Tissue Proteins; Oncorhynchus mykiss; Pro-Opiomelanocortin; Pyrazines; Quinoxalines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; RNA, Messenger; Serotonin Receptor Agonists	2016
Rat exposure in mice with neuropathic pain induces fear and antinociception that is not reversed by 5-HT2C receptor activation in the dorsal periaqueductal gray. Behavioural brain research, 2016, 07-01, Volume: 307 Topics: Analysis of Variance; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Exploratory Behavior; Fear; Male; Mice; Microinjections; Pain Measurement; Periaqueductal Gray; Pyrazines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT2C; Sciatica; Serotonin Receptor Agonists	2016
Repeated administration of 5-hydroxytryptamine 2C agonist MK212 produces a sensitization effect of antipsychotic activity. IUBMB life, 2016, Volume: 68, Issue:12 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Motor Activity; Pyrazines; Rats, Sprague-Dawley; Serotonin Receptor Agonists	2016
NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory. The international journal of neuropsychopharmacology, 2018, 03-01, Volume: 21, Issue:3 Topics: Animals; Dendritic Spines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Emotions; Excitatory Amino Acid Agents; HEK293 Cells; Hippocampus; Humans; Learning; Male; Memory; Molecular Structure; Neuronal Plasticity; Oligopeptides; Pyramidal Cells; Pyrazines; Rats; Receptors, N-Methyl-D-Aspartate	2018
Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice. Glia, 2018, Volume: 66, Issue:4 Topics: Animals; Anticonvulsants; Brain; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Transporter 2; Forkhead Transcription Factors; Homeodomain Proteins; Male; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nuclear Proteins; Pentylenetetrazole; Pyrazines; Receptors, N-Methyl-D-Aspartate; Seizures; Transcription Factors	2018
Remaining Need for In Vitro Test to Elucidate 5-Hydroxytryptamine 2C Receptor Functioning. Journal of clinical psychopharmacology, 2018, Volume: 38, Issue:4 Topics: Calcium; Digitonin; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Polymorphism, Single Nucleotide; Pyrazines; Receptor, Serotonin, 5-HT2C; Serotonin	2018
Interplay between 5-HT Neuropharmacology, 2018, 09-15, Volume: 140 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Dose-Response Relationship, Drug; Drug Interactions; Fear; Indoles; Male; Mice; Microinjections; Nociception; Pain Measurement; Periaqueductal Gray; Pyrazines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists	2018
Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. Nature neuroscience, 2018, Volume: 21, Issue:10 Topics: Action Potentials; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cerebellum; Excitatory Amino Acid Agents; Glycine; Guanine Nucleotide Exchange Factors; Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Nerve Fibers; Neural Pathways; Neurons; Neuropeptides; Principal Component Analysis; Pyrazines; Reaction Time; Synaptic Transmission	2018
Role of 5-HT2C receptors of the dorsal hippocampus in the modulation of anxiety- and panic-related defensive responses in rats. Neuropharmacology, 2019, Volume: 148 Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Ethylamines; Hippocampus; Imipramine; Indoles; Male; Maze Learning; Microinjections; Panic; Piperazines; Punishment; Pyrazines; Rats; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists	2019
The negative allosteric modulator of mGluR5, MPEP, potentiates the rewarding properties of cocaine in priming-induced reinstatement of CPP. Adicciones, 2020, Jul-01, Volume: 32, Issue:3 Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Extinction, Psychological; Female; Male; Mice; Pyrazines; Receptor, Metabotropic Glutamate 5	2020
MK212, a 5-hydroxytryptamine 2C receptor agonist, reverses prepulse inhibition deficits in the medial prefrontal cortex and ventral hippocampus. Progress in neuro-psychopharmacology & biological psychiatry, 2022, 03-08, Volume: 113 Topics: Aminopyridines; Animals; Brain; Dizocilpine Maleate; Hippocampus; Indoles; Mice; Prefrontal Cortex; Prepulse Inhibition; Pyrazines; Receptor, Serotonin, 5-HT2C; Receptors, N-Methyl-D-Aspartate	2022