pyrazines has been researched along with 5-(4-acetamidophenyl)pyrazin-2(1h)-one in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (28.95) | 18.7374 |
| 1990's | 26 (68.42) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, AM; Harris, DA | 2 |
| Beleta, J; Berga, P; Bou, J; Cardelús, I; Fernández, AG; Gristwood, RW; Llenas, J | 1 |
| Burns, F; Pyne, NJ | 2 |
| Lugnier, C; Muller, B; Stoclet, JC | 2 |
| Hall, IP; Hill, SJ | 1 |
| Barnette, MS; Barone, FC; Fowler, PJ; Grous, M; Ormsbee, HS; Price, WJ | 1 |
| Barnes, PJ; Rhoden, KJ | 1 |
| Diocee, BK; Martin, W; Moodie, SA; Souness, JE | 1 |
| Bailey, IA; Kemp, PR; Radda, GK; Seymour, AM | 1 |
| Barnette, MS; Grous, M; Ormsbee, HS; Torphy, TJ | 1 |
| English, TA; Gristwood, RW; Owen, DA; Sampford, KA; Wallwork, J | 1 |
| Bryson, SE; Rodger, IW | 1 |
| Reeves, ML; Rink, TJ; Simpson, AW | 1 |
| Brown, AM; Hill, SJ; Stanley, C | 1 |
| Betton, GR; Isaacs, KR; Joseph, EC | 1 |
| Eden, RJ; Gristwood, RW; Owen, DA; Taylor, EM | 1 |
| England, PJ; Leigh, BK; Reeves, ML | 1 |
| Barrett, RJ; Harleman, JH; Joseph, EC | 1 |
| Blake, TJ; Chenery, RJ; Metcalf, R; Osborne, PM; Pue, MA; Ross, DA | 1 |
| Fernandes, KA; Jelly, JA; Leavens, WJ; McDowall, RD; Pearce, JC | 1 |
| Eden, RJ; Harleman, JH; Joseph, EC; Lamb, MS; Major, IR; Walker, TF | 1 |
| Barnette, M; Grous, M | 1 |
| Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Harding, SE; Poole-Wilson, PA; Wynne, DG | 1 |
| Eckly, AE; Lugnier, C | 1 |
| Hellewell, PG; Rossi, AG; Teixeira, MM; Williams, TJ | 1 |
| Furman, BL; Pyne, NJ; Shafiee-Nick, R | 1 |
| Eckly, A; Lugnier, C; Okruhlicová, L; Slezák, J; Tribulová, N | 1 |
| Berto, L; Cortijo, J; Morcillo, EJ; Navarrete, C; Perpiñá, M; Sanz, C; Villagrasa, V | 1 |
| Berto, L; Bonnet, PA; Cortijo, J; Michel, A; Morcillo, EJ; Navarrete, C; Sanz, C; Villagrasa, V | 1 |
| Eckly-Michel, AE; Le Bec, A; Lugnier, C | 1 |
| Eckly-Michel, A; Lugnier, C; Martin, V | 1 |
| Barnes, PJ; Belvisi, MG; Bernareggi, MM; Giembycz, MA; Patel, H | 1 |
| Keravis, T; Le Bec, A; Lugnier, C; Pauvert, O; Proteau, S; Rousseau, E | 1 |
| Benezech, V; Bonnet, P; Chapat, J; Deleuze-Masquefa, C; Elliott, K; Escale, R; Fabreguettes, J; Laurent, F; Michel, A; Parra, S; Pocock, T; Small, R; Subra, G; Vidal, J | 1 |
38 other study(ies) available for pyrazines and 5-(4-acetamidophenyl)pyrazin-2(1h)-one
| Article | Year |
|---|---|
Mitochondrial ATP synthase regulation in heart: defects in hypertension are restored after treatment with captopril.
Topics: Animals; Captopril; Cardiotonic Agents; Cells, Cultured; Electric Stimulation; Hypertension; Isoproterenol; Male; Mitochondria, Heart; Multienzyme Complexes; Myocardium; NADH, NADPH Oxidoreductases; Proton-Translocating ATPases; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ruthenium Red; Verapamil | 1992 |
Studies on the cardiac actions of flosequinan in vitro.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Action Potentials; Animals; Carbachol; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; Vasodilator Agents | 1992 |
Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaline Phosphatase; Animals; Cyclic GMP; Enzyme Activation; Guinea Pigs; Isoenzymes; Kinetics; Lung; Macromolecular Substances; Protein Kinases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1992 |
Implication of cyclic AMP in the positive inotropic effects of cyclic GMP-inhibited cyclic AMP phosphodiesterase inhibitors on guinea pig isolated left atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Chloride; Cardiotonic Agents; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Protoveratrines; Pyrazines; Pyridones; Sodium | 1990 |
Control of mitochondrial ATP synthase in heart cells: inactive to active transitions caused by beating or positive inotropic agents.
Topics: Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Enzyme Activation; Isoproterenol; Male; Mitochondria, Heart; Multienzyme Complexes; Myocardial Contraction; NADH, NADPH Oxidoreductases; Propranolol; Proton-Translocating ATPases; Pyrazines; Rats; Rats, Inbred Strains; Ruthenium Red | 1990 |
Involvement of rolipram-sensitive cyclic AMP phosphodiesterase in the regulation of cardiac contraction.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Atenolol; Calcium Chloride; Colforsin; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Reserpine; Rolipram; Stereoisomerism; Xanthines | 1990 |
Effects of isozyme selective phosphodiesterase inhibitors on bovine tracheal smooth muscle tone.
Topics: Animals; Bronchodilator Agents; Cattle; Dose-Response Relationship, Drug; In Vitro Techniques; Isoenzymes; Methacholine Chloride; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rolipram; Trachea | 1992 |
Human lower oesophageal sphincter relaxation is associated with raised cyclic nucleotide content.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cyclic AMP; Cyclic GMP; Electric Stimulation; Esophagogastric Junction; Humans; In Vitro Techniques; Muscle Relaxation; Nitroprusside; Nucleotides, Cyclic; Purinones; Pyrazines; Tetrodotoxin | 1991 |
Potentiation of nonadrenergic neural relaxation in guinea pig airways by a cyclic cAMP phosphodiesterase inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Ethylmaleimide; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nitroprusside; Potassium Chloride; Pyrazines; Tetrodotoxin; Trachea; Vasoactive Intestinal Peptide | 1990 |
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic GMP; Dipyridamole; Endothelium, Vascular; Isoquinolines; Kinetics; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines | 1990 |
Metabolic consequences of positive inotropy in rat and guinea-pig hearts.
Topics: Acidosis; Animals; Chemical Phenomena; Chemistry; Cyclic AMP; Guinea Pigs; Heart; Heart Rate; Isoproterenol; Lactates; Magnetic Resonance Spectroscopy; Male; Myocardium; Perfusion; Phosphates; Pyrazines; Rats | 1990 |
Activation of cyclic AMP-dependent protein kinase during canine lower esophageal sphincter relaxation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Electric Stimulation; Enzyme Activation; Esophagogastric Junction; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Protein Kinases; Purinones; Pyrazines | 1990 |
Analysis of responses to a selective phosphodiesterase III inhibitor, SK&F 94120, on isolated myocardium, including human ventricular myocardium from "end-stage" failure patients.
Topics: Animals; Carbachol; Cats; Female; Guinea Pigs; Heart Failure; Heart Ventricles; Humans; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyrazines; Swine | 1987 |
Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Airway Resistance; Animals; Cyclic AMP; Cyclic GMP; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyrazines | 1987 |
Effects of SK&F 94120, an inhibitor of cyclic nucleotide phosphodiesterase type III, on human platelets.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenosine Diphosphate; Blood Platelets; Collagen; Cyclic AMP; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyrazines | 1988 |
Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cerebral Cortex; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine; Isoenzymes; Male; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1989 |
Coronary vascular lesions in dogs treated with phosphodiesterase III inhibitors.
Topics: Aminophylline; Animals; Coronary Disease; Coronary Vessels; Digoxin; Dogs; Electrocardiography; Female; Guanidines; Male; Myocardium; Phosphodiesterase Inhibitors; Pyrazines; Pyridazines; Pyridines | 1989 |
Pharmacological studies with SK&F 94120, a novel positive inotropic agent with vasodilator activity.
Topics: Animals; Cardiotonic Agents; Cats; Female; Guinea Pigs; Hemodynamics; In Vitro Techniques; Isoproterenol; Male; Microspheres; Pyrazines; Rats; Rats, Inbred Strains; Species Specificity; Time Factors; Vascular Resistance; Vasodilator Agents | 1986 |
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Chromatography, Ion Exchange; Guinea Pigs; Heart Ventricles; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Molecular Weight; Myocardium; Pyrazines; Pyrrolidinones; Rolipram | 1987 |
The evaluation of HBDH and LDH isoenzymes in cardiac cell necrosis of the rat.
Topics: Animals; Female; Heart; Humans; Hydroxybutyrate Dehydrogenase; Isoenzymes; Isoproterenol; L-Lactate Dehydrogenase; Male; Myocardium; Necrosis; Pyrazines; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
The metabolism of 5-(4-acetamidophenyl)pyrazin-2(1H)-one in rat, dog and cynomolgus monkey.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dogs; Glucuronates; In Vitro Techniques; Liver; Macaca fascicularis; Male; Pyrazines; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Analysis of 5-(4-acetamidophenyl)pyrazin-2(1H)-one (SK&F 94120) in plasma with an Analytichem automated sample processor liquid chromatography module.
Topics: Animals; Autoanalysis; Cardiotonic Agents; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Pyrazines; Spectrophotometry, Ultraviolet | 1986 |
Cardiotoxicity of a new inotrope/vasodilator drug (SK&F 94120) in the dog.
Topics: Animals; Dogs; Electrocardiography; Female; Heart; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Pyrazines; Stimulation, Chemical; Time Factors; Vasodilator Agents | 1986 |
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antigens; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Immunization; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1994 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Incomplete reversal of beta-adrenoceptor desensitization in human and guinea-pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Guanidines; Guinea Pigs; Heart; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Norepinephrine; Pyrazines; Pyridazines | 1993 |
Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram | 1994 |
Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig.
Topics: Animals; Calmodulin; Cardiotonic Agents; Dermatitis; Edema; Eosinophils; Female; Guinea Pigs; In Vitro Techniques; Indium Radioisotopes; Isoenzymes; Male; Neutrophils; Passive Cutaneous Anaphylaxis; Phosphodiesterase Inhibitors; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Skin | 1994 |
Lung phosphodiesterase isoenzymes.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Catalysis; Enzyme Activation; Guinea Pigs; Isoenzymes; Lung; Muscle, Smooth; Perfusion; Phosphoric Diester Hydrolases; Purinones; Pyrazines | 1993 |
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes | 1995 |
Cytochemical distribution of cyclic AMP-dependent 3',5'-nucleotide phosphodiesterase in the rat myocardium.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Histocytochemistry; Isoenzymes; Myocardium; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rolipram | 1996 |
Inhibition of phosphodiesterase IV and intracellular calcium levels in human polymorphonuclear leukocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Calcium; Cardiotonic Agents; Cell Survival; Chemotaxis; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Fura-2; Humans; Imidazoles; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Parasympatholytics; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Rolipram; Thimerosal | 1996 |
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bronchi; Bronchodilator Agents; Calcium; Cardiotonic Agents; Cromakalim; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Leukocyte Elastase; Leukotriene B4; Muscle Relaxation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoric Diester Hydrolases; Pyrazines; Pyrroles; Pyrrolidinones; Rolipram; Superoxides | 1996 |
Chelerythrine, a protein kinase C inhibitor, interacts with cyclic nucleotide phosphodiesterases.
Topics: Adrenergic beta-Agonists; Alkaloids; Animals; Aorta; Benzophenanthridines; Cardiotonic Agents; Cattle; Drug Interactions; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Glycoproteins; Hydrolysis; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenanthridines; Protein Kinase C; Pyrazines; Rats; Rats, Wistar | 1997 |
Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Aorta; Calcium; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Sulfonamides; Thionucleotides | 1997 |
Anti-spasmogenic activity of isoenzyme-selective phosphodiesterase inhibitors in guinea-pig trachealis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylcholine; Animals; Antihypertensive Agents; Cardiotonic Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Histamine; In Vitro Techniques; Isoenzymes; Male; Muscle Contraction; Muscle, Smooth; Nitroprusside; Parasympatholytics; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Trachea | 1999 |
Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Nucleus; Chromatography, High Pressure Liquid; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Ventricles; Intracellular Membranes; Isoenzymes; Myocardium; Pyrazines; Rolipram; Sheep | 1999 |
Imidazo[1,2-a]quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cardiotonic Agents; Cattle; Enzyme Inhibitors; Guinea Pigs; Inhibitory Concentration 50; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Muscle Relaxation; Muscle, Smooth; Nitriles; Pyrazines; Quinoxalines; Structure-Activity Relationship | 2001 |