pyrazines has been researched along with 4-aminopyridine in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Gwilt, M; Henderson, CG; Orme, J; Rourke, JD | 2 |
| Berg, T | 1 |
| Acosta, MC; Belmonte, C; del Olmo, S; Dhaka, A; Echevarria, D; Gallar, J; Madrid, R; Morenilla-Palao, C; Parra, A; Viana, F | 1 |
| Aherne, GW; Box, G; Boxall, KJ; Collins, I; De Haven Brandon, AK; Eccles, SA; Eve, PD; Garrett, MD; Hayes, A; Henley, AT; Hunter, JE; Lainchbury, M; Matthews, TP; McHardy, T; Osborne, J; Perkins, ND; Raynaud, FI; Reader, JC; Swales, K; Tall, M; Valenti, MR; Walton, MI | 1 |
| Aherne, GW; Box, G; Boxall, KJ; Brown, N; Cheung, KM; Collins, I; De Haven Brandon, AK; Eccles, SA; Eve, PD; Garrett, MD; Hayes, A; Henley, AT; Jamin, Y; Lainchbury, M; Lamers, MB; Leonard, PM; Matthews, TP; McHardy, T; Osborne, JD; Proisy, N; Raynaud, FI; Reader, JC; Robinson, SP; Valenti, MR; van Montfort, RL; Walton, MI; Westwood, IM | 1 |
| Fan, Z; Lai, Q; Li, S; Liang, A; Luo, H; Wang, F; Wang, G; Wang, J; Xu, J; Xu, Y; Zhang, W; Zhou, J | 1 |
7 other study(ies) available for pyrazines and 4-aminopyridine
| Article | Year |
|---|---|
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation | 1992 |
K(+)-channel blockers and coronary vasoconstriction in guinea-pig perfused hearts in-vitro.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Coronary Vessels; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Perfusion; Phentolamine; Potassium Channels; Pyrazines; Pyridines; Vasoconstriction | 1993 |
The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.
Topics: 4-Aminopyridine; Adrenalectomy; Adrenergic Antagonists; Amifampridine; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Indomethacin; Losartan; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Potassium Channel Blockers; Prazosin; Protein Kinase C; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Staurosporine; Sulfonamides; Vascular Resistance; Vasoconstriction | 2003 |
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.
Topics: 4-Aminopyridine; Animals; Cold Temperature; Cornea; Dry Eye Syndromes; Menthol; Mice; Mice, Transgenic; Ocular Physiological Phenomena; Pyrazines; Pyridines; Shaker Superfamily of Potassium Channels; Tears; Thermoreceptors; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels | 2010 |
The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.
Topics: 4-Aminopyridine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; Cyclin-Dependent Kinases; Deoxycytidine; DNA Damage; Drug Synergism; Gemcitabine; HT29 Cells; Humans; Irinotecan; Lung Neoplasms; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Pyrazines; Xenograft Model Antitumor Assays | 2016 |
Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
Topics: 4-Aminopyridine; Checkpoint Kinase 1; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Pyrazines; Structure-Activity Relationship | 2016 |
Checkpoint kinase‑1 inhibition and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologous recombination DNA damage repair.
Topics: 4-Aminopyridine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Checkpoint Kinase 1; Comet Assay; DNA Damage; DNA Repair; Drug Synergism; Etoposide; Homologous Recombination; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Protein Kinase Inhibitors; Pyrazines; Topoisomerase II Inhibitors | 2020 |