pyrazines has been researched along with 3,4-dihydroxyphenyllactic acid in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, D | 1 |
| Guo, ZQ; Wang, SR; Zhu, LQ | 1 |
| Chen, Y; Cui, Q; Shan, L; Sun, Y; Wang, D; Wang, Y; Xu, B; Xu, Q; Yu, P; Zhang, G; Zhang, M; Zhao, Z | 1 |
| Li, S; Li, W; Liao, K; Shan, L; Sheng, X; Wang, Y; Yu, P; Zhang, Z | 1 |
| Gong, Z; Huang, Y; Lan, Y; Liu, Y; Lu, Y; Wang, A; Wang, Y; Xie, Y; Zheng, L | 1 |
| Shan, L; Sun, Y; Wang, Y; Xu, C; Yu, P; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Deng, H; Hu, H; Luo, J; Shan, L; Wang, Y; Yu, P; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Deng, H; Hu, H; Huang, Y; Luo, J; Shan, L; Sun, Y; Wang, Y; Yu, P; Zhang, X | 1 |
| Deng, H; Luo, J; Shan, L; Wang, Y; Xu, B; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Chen, J; Hui, A; Wu, Z; Yang, L; Yin, H; Zhang, W; Zhang, Z; Zhou, A | 1 |
1 review(s) available for pyrazines and 3,4-dihydroxyphenyllactic acid
| Article | Year |
|---|---|
[Advances in the study on transdermal permeation of active elements of natural drugs in vitro].
Topics: Administration, Cutaneous; Animals; Drugs, Chinese Herbal; Lactates; Morphinans; Plants, Medicinal; Pyrazines; Skin Absorption | 2002 |
9 other study(ies) available for pyrazines and 3,4-dihydroxyphenyllactic acid
| Article | Year |
|---|---|
[Effect of danshensu and ligustrazine on related genes of myocardial hypertrophy induced by angiotensin II].
Topics: Angiotensin II; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Drugs, Chinese Herbal; Female; Lactates; Male; Myocytes, Cardiac; Pyrazines; Rats; Rats, Wistar; RNA, Messenger | 2005 |
Design, synthesis, and preliminary cardioprotective effect evaluation of danshensu derivatives.
Topics: Animals; Cardiotonic Agents; Cell Line, Tumor; Creatine Kinase; Disease Models, Animal; Drug Design; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heme Oxygenase-1; Ischemia; L-Lactate Dehydrogenase; Lactates; Malondialdehyde; NF-E2-Related Factor 2; Phenylpropionates; Phosphatidylinositol 3-Kinases; Protein Binding; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Signal Transduction; Stereoisomerism | 2014 |
Pharmacokinetic and Metabolic Studies of ADTM: A Novel Danshensu Derivative Confers Cardioprotection by HPLC-UV and LC-MS/MS.
Topics: Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Humans; Lactates; Limit of Detection; Linear Models; Male; Phenylpropionates; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
A UPLC-MS/MS method for simultaneous determination of danshensu, protocatechuic aldehyde, rosmarinic acid, and ligustrazine in rat plasma, and its application to pharmacokinetic studies of Shenxiong glucose injection in rats.
Topics: Animals; Benzaldehydes; Catechols; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Drugs, Chinese Herbal; Female; Injections, Intravenous; Lactates; Limit of Detection; Linear Models; Male; Pyrazines; Rats, Sprague-Dawley; Reproducibility of Results; Rosmarinic Acid; Tandem Mass Spectrometry | 2015 |
Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Lactates; Male; Molecular Structure; Myocardial Ischemia; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship | 2017 |
A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway.
Topics: Animals; Cell Line; Cell Survival; Free Radicals; Heme Oxygenase-1; Iodoacetic Acid; Lactates; Ligusticum; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; NF-E2-Related Factor 2; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Salvia miltiorrhiza; tert-Butylhydroperoxide; Up-Regulation | 2017 |
A Novel Danshensu-Tetramethylpyrazine Conjugate DT-018 Provides Cardioprotection by Preserving Mitochondrial Function Through the MEF2D/PGC-1α Pathway.
Topics: Animals; Cardiotonic Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Lactates; MEF2 Transcription Factors; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pyrazines; Rats; Structure-Activity Relationship | 2018 |
A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs.
Topics: Animals; Arterial Pressure; Calcium; Cardiotonic Agents; Coronary Circulation; Cyclic GMP; Dogs; Extracellular Matrix; Intracellular Space; Lactates; Male; Myocardial Infarction; Nitric Oxide; Potassium Channels; Pyrazines; Rats; Receptors, Adrenergic, beta; Vasodilation; Vasodilator Agents | 2018 |
Enhancement of brain-targeting delivery of danshensu in rat through conjugation with pyrazine moiety to form danshensu-pyrazine ester.
Topics: Animals; Brain; Drug Delivery Systems; Drug Liberation; Esters; Half-Life; Lactates; Prodrugs; Pyrazines; Rats, Sprague-Dawley | 2018 |