pyrazines has been researched along with 2-pyrazinoylguanidine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 16 (88.89) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beyer, KH; Gelarden, RT; Jeszenka, EV; Passananti, GT; Vesell, ES | 1 |
| Beyer, KH; Chambers, CE; Helm, C; Passananti, GT; Vesell, ES | 1 |
| Beyer, KH; Gelarden, RT; Vesell, ES | 1 |
| Beyer, KH; Brown, LE; Gelarden, RT; Vary, JE; Vesell, ES | 1 |
| Beyer, KH; Gelarden, RT | 1 |
| Beyer, KH; Chambers, CE; Demers, LM; Passananti, GT; Seaton, TD; Vesell, ES | 1 |
| Beyer, KH; Chambers, CE; Demers, LM; Passananti, GT; Vesell, ES | 1 |
| Dytko, G; Kinter, LB; Smith, PL | 1 |
| Beyer, KH; Gelarden, RT; Knutson, DW; Vary, JE; Vesell, ES; Ward, TD | 1 |
| A-Rahim, YI; Beyer, KH; Vesell, ES | 3 |
| A-Rahim, YI; Beyer, KH; Kimball, SR; Rannels, SL; Vesell, ES | 1 |
| Beyer, KH; Follansbee, MH; Griffith, JW; Vesell, ES | 1 |
| Beyer, KH; Follansbee, MH; Vesell, ES | 1 |
| Ahsan, N; Beyer, KH; Korsunsky, Z; Vesell, ES | 1 |
| Beyer, KH; Vesell, ES | 2 |
1 review(s) available for pyrazines and 2-pyrazinoylguanidine
| Article | Year |
|---|---|
Studies on pyrazinoylguanidine: a novel antihypertensive, hypoglycemic and lipolytic drug intended for adjunctive use in hypertensive patients with type 2 diabetes mellitus.
Topics: Animals; Antihypertensive Agents; Biological Transport, Active; Diabetes Mellitus, Type 2; Guanidines; Humans; Hypertension; Hypoglycemic Agents; Hypolipidemic Agents; Kidney Diseases; Pyrazines; Rats | 2000 |
5 trial(s) available for pyrazines and 2-pyrazinoylguanidine
| Article | Year |
|---|---|
Pyrazinoylguanidine: antihypertensive, hypocholesterolemic, and renin effects.
Topics: Aged; Blood Pressure; Cholesterol; Dose-Response Relationship, Drug; Female; Guanidines; Heart Rate; Humans; Hypercholesterolemia; Hypertension; Lipoproteins, LDL; Male; Middle Aged; Pyrazines; Renin-Angiotensin System; Single-Blind Method | 1992 |
Novel multivalent effects of pyrazinoylguanidine in patients with azotemia.
Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Creatinine; Electrolytes; Female; Glomerular Filtration Rate; Guanidines; Humans; Male; Middle Aged; Pyrazines; Renin-Angiotensin System; Sodium; Urea; Uremia | 1990 |
Effects of pyrazinoylguanidine on the glucose-fatty acid cycle in normal subjects and patients with non-insulin-dependent diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Down-Regulation; Fatty Acids; Female; Glucose Tolerance Test; Guanidines; Humans; Hydrochlorothiazide; Insulin; Male; Middle Aged; Pyrazines; Uremia | 1993 |
Pyrazinoylguanidine in end-stage renal disease: a prospective, placebo-controlled pilot study.
Topics: Administration, Oral; Adult; Blood Glucose; Cholesterol; Female; Guanidines; Humans; Hyperglycemia; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Pyrazines; Renal Dialysis; Triglycerides | 1998 |
Studies on pyrazinoylguanidine. 7. Effects of single oral doses in normal human subjects.
Topics: Adult; Blood Glucose; Cross-Over Studies; Fatty Acids, Nonesterified; Guanidines; Hormones; Humans; Hypolipidemic Agents; Lipids; Male; Pyrazinamide; Pyrazines; Single-Blind Method | 1999 |
12 other study(ies) available for pyrazines and 2-pyrazinoylguanidine
| Article | Year |
|---|---|
Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Drug Stability; Guanidines; Half-Life; Humans; Hydrolysis; Molecular Structure; Pyrazinamide; Pyrazines; Uremia | 1992 |
Inhibition of urea transport across renal tubules by pyrazinoylguanidine and analogs.
Topics: Amiloride; Animals; Biological Transport, Active; Dogs; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Guanidines; Kidney Tubules; Potassium; Pyrazines; Sodium; Structure-Activity Relationship; Urea | 1992 |
Active transport of urea by mammalian kidney.
Topics: Amiloride; Animals; Biological Transport, Active; Diuresis; Dogs; Guanidines; Kidney; Mannitol; Pyrazines; Urea | 1988 |
Pyrazinoylguanidine downregulates the glucose fatty-acid cycle in hypertensive, hyperinsulinemic diabetic patients.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Fatty Acids; Female; Glucose Tolerance Test; Guanidines; Humans; Hypertension; Male; Middle Aged; Pyrazines | 1994 |
Urea transport in toad skin (Bufo marinus)
Topics: Amiloride; Animals; Arginine Vasopressin; Biological Transport; Bufo marinus; Guanidines; Hydrogen-Ion Concentration; Kinetics; Ouabain; Phloretin; Pyrazines; Skin; Sodium Chloride; Urea; Urinary Bladder | 1993 |
Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency.
Topics: Adult; Aged; Blood Glucose; Cholesterol; Electrolytes; Female; Guanidines; Humans; Hydrochlorothiazide; Male; Middle Aged; Pyrazines; Renal Insufficiency; Single-Blind Method; Triglycerides; Urea | 1993 |
Studies on pyrazinoylguanidine. 1. Characterization of metabolic effects in diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Female; Guanidines; Hydrochlorothiazide; Hypoglycemic Agents; Hypolipidemic Agents; Lipids; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Rats, Zucker; Streptozocin | 1996 |
Studies on pyrazinoylguanidine. 2. Comparative drug and dose effects on glucose and lipid metabolism in streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Guanidines; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Male; Metformin; Pyrazinamide; Pyrazines; Rats; Rats, Sprague-Dawley; Streptozocin | 1996 |
Studies on pyrazinoylguanidine. 3. Downregulation of lipolysis in isolated adipocytes.
Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Down-Regulation; Glycerol; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Isoproterenol; Lipase; Lipolysis; Male; Pertussis Toxin; Pyrazines; Rats; Rats, Sprague-Dawley; Virulence Factors, Bordetella | 1996 |
Studies on pyrazinoylguanidine. 4. Upregulation of phosphodiesterase activity in rat adipose tissue and downregulation of gluconeogenesis and adenosine 3',5'-monophosphate concentrations in perfused rat liver.
Topics: Adipocytes; Adipose Tissue; Animals; Cell Membrane; Cyclic AMP; Down-Regulation; Gluconeogenesis; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Liver; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Rats; Rats, Sprague-Dawley; Theophylline; Up-Regulation | 1996 |
Studies on pyrazinoylguanidine. 5. Temporal effects over 24 weeks demonstrating attenuation of diabetic nephropathy in STZ-diabetic rats.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Guanidines; Hydrochlorothiazide; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Kidney; Kidney Function Tests; Male; Molecular Weight; Pyrazines; Rats; Rats, Sprague-Dawley; Serum Albumin; Streptozocin | 1997 |
Studies on pyrazinoylguanidine. 6. Prevention of cataracts in STZ-diabetic rats.
Topics: Animals; Antihypertensive Agents; Captopril; Cataract; Diabetes Mellitus, Experimental; Guanidines; Hypoglycemic Agents; Male; Odds Ratio; Pyrazines; Rats; Rats, Sprague-Dawley; Streptozocin | 1997 |