Compounds > pyrazines
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pyrazines and 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one

pyrazines has been researched along with 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one in 63 studies

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's36 (57.14)18.2507
2000's21 (33.33)29.6817
2010's4 (6.35)24.3611
2020's2 (3.17)2.80

Authors

AuthorsStudies
Koga, S; Nakano, M2
Fukumura, D; Oguchi, Y; Shimmura, S; Suematsu, M; Tsubota, K; Tsuchiya, M1
Arimori, S; Fehér, J; Hiramatsu, K; Ichimori, K; Nakazawa, H; Ohkubo, T; Prónai, L; Saigusa, Y1
Kobayashi, H; Kobayashi, S; Kurosawa, M; Nakano, M1
Ichimori, K; Nakazawa, H; Prónai, L; Saigusa, Y1
Koga, S; Nakano, M; Uehara, K1
Kato, M; Kimura, H; Kuroume, T; Morikawa, A; Nakano, M; Shigeta, M1
Hori, K; Koga, S; Nakano, M; Uehara, K1
Ishizuka, T; Kobayashi, S; Kurosawa, M; Nakano, M; Yodoi, J1
Ishizuka, T; Kobayashi, S; Kurosawa, M; Nakano, M1
Inaba, H; Mashiko, S; Nakano, M; Takahashi, A1
Hishinuma, K; Hosono, A; Inaba, H; Kimura, S; Mashiko, S1
Hara, M; Kato, M; Kimura, H; Kuroiwa, M; Nakano, M; Totsune, K; Yoshikawa, T1
Nakano, M2
Inaba, H; Kishimoto, W; Nakano, M; Nakao, A; Takagi, H; Takahashi, A1
Adachi, M; Hasegawa, T; Hashimura, E; Hiraishi, K; Ito, T; Kikuyama, M; Nakano, M; Sakurai, K1
Fujiwara, T; Hattori, K; Hirata, Y; Kobayashi, Y; Kojima, T1
Huang, CK; Maruyama, N; Nakano, M; Uehara, K1
Aramaki, Y; Ichimori, Y; Masuya, H; Nishinaka, Y; Sugawara, T; Yoshida, H1
Adachi, M; Ando, S; Dobashi, K; Hisada, T; Ishizuka, T; Mori, M; Morita, K1
Nakano, M; Nakashima, M; Nishiyama, H; Saniabadi, AR; Takiguchi, Y; Umemura, K; Wada, K1
Konishi, T; Matsugo, S; Matsuo, D; Packer, L; Tritschler, HJ1
Itoh, T; Kamisaki, Y; Nakamoto, K; Wada, K1
de Lamirande, E; Gagnon, C1
Maruyama, Y; Nakano, M; Ushiroda, S1
Sakurai, T; Terakawa, S2
Ito, T; Kambayashi, Y; Nakano, M; Watanabe, K; Yamamoto, Y2
Ishimatsu, A; Kawano, I; Muramatsu, T; Nakamura, A; Oda, T; Shikayama, M1
Tampo, Y; Tsukamoto, M; Yonaha, M2
Yu, CA; Yu, L; Zhang, L1
Kiuchi, Y; Konno, D; Nara, K; Oguchi, K; Uchida, J1
Hata, Y; Kawazoe, T; Kosaka, H; Yoneyama, H1
Crause, P; Gloe, T; Keller, M; Pohl, U; Sohn, HY1
Ishimatsu, A; Kim, D; Muramatsu, T; Oda, T1
Boucher, D; Grizard, G; Motta, C; Saez, F1
Iida, T; Ishimatsu, A; Kim, D; Komatsu, N; Muramatsu, T; Nakamura, A; Oda, T; Okamoto, T1
Okamoto, K; Tanaka, M; Yoshida, T1
Maehara, K; Maruyama, Y; Midorikawa, J; Ohtani, H; Ushiroda, S; Watanabe, T; Yaoita, H1
Masuda, H; Naito, M; Tamai, H; Tanaka, T; Tateishi, M1
Aoki, S; Ito-Kuwa, S; Nakamura, K; Nakamura, Y; Takeo, K; Vidotto, V1
Wang, J; Xing, D1
Cheng, W; Hisadome, K; Ito, Y; Karashima, Y; Kimura, C; Koyama, T; Oike, M; Wang, YP1
Adachi, M; Hasegawa, T; Kambayashi, Y; Kikuyama, M; Kuwano, H; Nakano, M; Sakurai, K; Saniabadi, AR1
Fukuuchi, Y; Itoh, Y; Uematsu, D; Watanabe, S; Yamaguchi, K1
Kato, M; Kimura, H; Kobayashi, Y; Kozawa, K; Kuroiwa, M; Minakami, H; Morikawa, A; Oshima, S1
Nishiguchi, T; Teranishi, K; Ueda, H1
Kambayashi, Y; Ogino, K1
Hasegawa, T; Kambayashi, Y; Kuwano, H; Nagamoto, H; Nakano, M; Sakurai, K; Saniabadi, AR; Takahashi, A; Tsukada, K1
Nishiguchi, T; Teranishi, K1
Aoki, S; Ito-Kuwa, S; Majima, T; Masui, S; Nakamura, K; Takeo, K1
Aitken, RJ; Baker, MA; Curry, BJ; Hetherington, L; Krutskikh, A1
Moffett, JW; Rose, AL; Waite, TD1
Croot, PL; Heller, MI1
Akatov, VS; Fisyuk, AS; Kruglov, AG; Nikiforova, AB; Shatalin, YV; Shubina, VV1
Kharechkina, ES; Kruglov, AG; Nikiforova, AB1
Hara, A; Hattori, M; Kazumura, K; Miwa, T; Morishita, N; Osawa, T; Takeuchi, K; Tsuchiya, H; Wu, Y1
Bartelink-Clements, C; Basmeleh, A; Batlle, E; Boj, SF; Cabellos, L; Cañellas-Socias, A; Chicote, I; Clevers, H; Cortina, C; de Kruif, J; Eppink, B; Fatrai, S; Glodzik, D; Hernando-Momblona, X; Herpers, B; James, MI; Lammerts van Bueren, JJ; Logtenberg, T; Mateos, JG; Maussang, D; Nuciforo, P; Palmer, HG; Price, LS; Ramírez, L; Roovers, RC; Salazar, R; Salinaro, L; Sancho, E; Santos, C; Serna, G; Stephan-Otto Attolini, C; Stratton, MR; Tabernero, J; Throsby, M; van de Wetering, M; Villanueva, A; Vries, RGJ; Yan, K; Zondag-van der Zande, V1

Other Studies

63 other study(ies) available for pyrazines and 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one

ArticleYear
A high involvement of O2- possibly generated in inner membranes for iron-induced microsomal lipid peroxidation.
    Biochemical and biophysical research communications, 1992, Jul-31, Volume: 186, Issue:2

    Topics: Animals; Ceruloplasmin; Copper; Cytochrome P-450 Enzyme System; Erythrocytes; Free Radical Scavengers; Imidazoles; Intracellular Membranes; Iron; Lipid Peroxidation; Luminescent Measurements; Microsomes, Liver; Milk; Models, Biological; Organometallic Compounds; Pyrazines; Rats; Salicylates; Superoxide Dismutase; Superoxides; Xanthine Oxidase

1992
Oxiradical-dependent photoemission induced by a phacoemulsification probe.
    Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:10

    Topics: Azides; Cataract Extraction; Cytochrome c Group; Free Radicals; Imidazoles; Luminescent Measurements; Pyrazines; Radiation; Sodium Azide; Superoxide Dismutase; Superoxides; Ultrasonography

1992
Time course of superoxide generation by leukocytes--the MCLA chemiluminescence system.
    Inflammation, 1992, Volume: 16, Issue:5

    Topics: Cell Separation; Cell Survival; Cytochrome c Group; Electron Spin Resonance Spectroscopy; Humans; Imidazoles; Leukocytes; Luminescent Measurements; Luminol; Peroxidase; Pyrazines; Superoxides

1992
Failure of inhibitory effects by platelets on super-oxide anion generation from stimulated neutrophils in a severe bronchial asthmatic.
    Allergy, 1991, Volume: 46, Issue:3

    Topics: Adult; Asthma; Blood Platelets; Cell Communication; Chromatography, Gel; Female; Humans; Imidazoles; Luminescent Measurements; Neutrophils; Platelet Count; Pyrazines; Superoxide Dismutase; Superoxides

1991
5,5-dimethyl-1-pyrroline-N-oxide alone enhances the spontaneous superoxide generation by primaquine.
    Archives of biochemistry and biophysics, 1991, Volume: 288, Issue:1

    Topics: Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Imidazoles; Luminescent Measurements; Primaquine; Pyrazines; Spectrophotometry; Spin Labels; Superoxides

1991
Mechanism for the generation of superoxide anion and singlet oxygen during heme compound-catalyzed linoleic acid hydroperoxide decomposition.
    Archives of biochemistry and biophysics, 1991, Volume: 289, Issue:2

    Topics: Catalysis; Heme; Imidazoles; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Luminescent Measurements; Oxidation-Reduction; Oxygen; Pyrazines; Singlet Oxygen; Superoxides

1991
Ability of polymorphonuclear leukocytes to generate active oxygen species in children with bronchial asthma. Use of chemiluminescence probes with a Cypridina luciferin analog and luminol.
    International archives of allergy and applied immunology, 1991, Volume: 95, Issue:1

    Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Female; Humans; Imidazoles; Luminol; Lymphocyte Activation; Male; Neutrophils; Pyrazines; Superoxides

1991
Highly sensitive chemiluminescence method for determining myeloperoxidase in human polymorphonuclear leukocytes.
    Analytical biochemistry, 1991, Volume: 199, Issue:2

    Topics: Deferoxamine; Free Radicals; Humans; Hydrogen Peroxide; Imidazoles; Neutrophils; Oxygen; Peroxidase; Pyrazines; Sensitivity and Specificity; Subcellular Fractions; Substrate Specificity; Superoxide Dismutase

1991
Effects of azelastine on superoxide anion generation from gamma interferon treated human monoblast cell line U937 measured by chemiluminescence method.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:1

    Topics: Cell Adhesion; Cell Line; Histamine H2 Antagonists; Humans; Imidazoles; Interferon-gamma; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Oxygen Consumption; Phthalazines; Pyrazines; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate

1991
Effects of antiallergic drugs on superoxide anion generation from activated human alveolar macrophages measured by chemiluminescence method.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:1

    Topics: Bronchoalveolar Lavage Fluid; Cromolyn Sodium; Histamine Antagonists; Histamine H2 Antagonists; Humans; Imidazoles; In Vitro Techniques; Ketotifen; Luminescent Measurements; Macrophages; Oxygen Consumption; Phthalazines; Pulmonary Alveoli; Pyrazines; Superoxide Dismutase; Superoxides

1991
The first observation of O2- generation in in situ lungs of rats treated with drugs to induce experimental acute respiratory distress syndrome.
    FEBS letters, 1990, Feb-26, Volume: 261, Issue:2

    Topics: Animals; Endotoxins; Imidazoles; Kinetics; Luminescence; Lung; Photometry; Pyrazines; Rats; Respiratory Distress Syndrome; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate

1990
Augmentation of superoxide generation in phagocytosing murine peritoneal macrophages by dietary restriction.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1990, Volume: 60, Issue:1

    Topics: Animals; Calmodulin; Diet, Reducing; Imidazoles; Luminescent Measurements; Macrophages; Male; Mice; Mice, Inbred C3H; Oxygen; Peritoneal Cavity; Phagocytosis; Protein Kinase C; Pyrazines; Superoxides; Zymosan

1990
A highly sensitive method for determining both Mn- and Cu-Zn superoxide dismutase activities in tissues and blood cells.
    Analytical biochemistry, 1990, Volume: 187, Issue:2

    Topics: Animals; Erythrocytes; Imidazoles; Luminescent Measurements; Male; Organ Specificity; Pyrazines; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Superoxide Dismutase

1990
Assay for superoxide dismutase based on chemiluminescence of luciferin analog.
    Methods in enzymology, 1990, Volume: 186

    Topics: Animals; Erythrocytes; Granulocytes; Humans; Imidazoles; Indicators and Reagents; Isoenzymes; Luminescent Measurements; Lymphocytes; Organ Specificity; Pyrazines; Rats; Superoxide Dismutase; Xanthine Oxidase

1990
Detection of superoxide free radicals in rats with acute pancreatitis.
    Pancreas, 1995, Volume: 11, Issue:2

    Topics: Acute Disease; Animals; Ceruletide; Free Radicals; Imidazoles; Kinetics; Luminescent Measurements; Male; Pancreas; Pancreatitis; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides

1995
The first observation of O2- generation at real time in vivo from non-Kupffer sinusoidal cells in perfused rat liver during acute ethanol intoxication.
    FEBS letters, 1995, Sep-25, Volume: 372, Issue:2-3

    Topics: Animals; Endothelium; Ethanol; Imidazoles; Kupffer Cells; Liver; Male; Perfusion; Pyrazines; Rats; Rats, Wistar; Superoxides

1995
Luciferin derivative for assay of myeloperoxidase and dopamine metabolism.
    Methods in enzymology, 1994, Volume: 233

    Topics: Basidiomycota; Dopamine; Electron Spin Resonance Spectroscopy; Humans; Imidazoles; Indicators and Reagents; Luminescent Measurements; Monophenol Monooxygenase; Neutrophils; Oxygen; Peroxidase; Photochemistry; Pyrazines; Singlet Oxygen; Superoxides

1994
Maturational changes in superoxide anion production of rabbit alveolar macrophages.
    Life sciences, 1994, Volume: 55, Issue:12

    Topics: Aging; Animals; Cells, Cultured; Endothelins; Imidazoles; Luminescent Measurements; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Pyrazines; Rabbits; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate

1994
The first application of a chemiluminescence probe, 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-3-one (MCLA), for detecting O2- production, in vitro, from Kupffer cells stimulated by phorbol myristate acetate.
    FEBS letters, 1993, Dec-06, Volume: 335, Issue:2

    Topics: Animals; Hypoxanthine; Hypoxanthines; Imidazoles; In Vitro Techniques; Kupffer Cells; Luminescent Measurements; Male; Pyrazines; Rats; Rats, Wistar; Superoxides; Tetradecanoylphorbol Acetate; Xanthine Oxidase

1993
A possible mechanism of iron neurotoxicity.
    European neurology, 1993, Volume: 33 Suppl 1

    Topics: Animals; Culture Techniques; Dose-Response Relationship, Drug; Imidazoles; Iron; Lipid Peroxidation; Microsomes, Liver; Neurotoxins; Pyrazines; Rats

1993
A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells.
    Biochemical and biophysical research communications, 1993, Jun-15, Volume: 193, Issue:2

    Topics: Complement C5a; Humans; Imidazoles; Indicators and Reagents; Interferon-gamma; Kinetics; Leukemia, Eosinophilic, Acute; Luminescent Measurements; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pyrazines; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
The direct effect of interferon-gamma on human eosinophilic leukemia cell lines: the induction of interleukin-5 mRNA and the presence of an interferon-gamma receptor.
    Inflammation, 1996, Volume: 20, Issue:2

    Topics: Antigens, CD; Base Sequence; Eosinophils; Gene Expression Regulation, Leukemic; Humans; Imidazoles; Interferon gamma Receptor; Interferon-gamma; Interleukin-5; Leukemia, Eosinophilic, Acute; Luminescent Measurements; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neoplasm Proteins; Neoplastic Stem Cells; Pyrazines; Receptors, Interferon; RNA, Messenger; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1996
A chemiluminescent detection of superoxide radical produced by adherent leucocytes to the subendothelium following thrombolysis: studies with a photochemically induced thrombosis model in the guinea pig femoral artery.
    Atherosclerosis, 1996, Volume: 122, Issue:2

    Topics: Animals; Cell Adhesion; Disease Models, Animal; Endothelium, Vascular; Femoral Artery; Guinea Pigs; Imidazoles; Light; Luminescent Measurements; Male; Neutrophils; Plasminogen Activators; Pyrazines; Recombinant Proteins; Rose Bengal; Superoxides; Thrombolytic Therapy; Thrombosis

1996
Reevaluation of superoxide scavenging activity of dihydrolipoic acid and its analogues by chemiluminescent method using 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo-[1,2-a]pyrazine-3-one (MCLA) as a superoxide probe.
    Biochemical and biophysical research communications, 1996, Oct-03, Volume: 227, Issue:1

    Topics: Cysteine; Free Radical Scavengers; Imidazoles; Luminescent Measurements; Molecular Probes; Pyrazines; Superoxides; Thioctic Acid

1996
Effect of cystathionine as a scavenger of superoxide generated from human leukocytes or derived from xanthine oxidase in vitro.
    European journal of pharmacology, 1996, Feb-05, Volume: 296, Issue:3

    Topics: Cystathionine; Erythrocyte Membrane; Free Radical Scavengers; Humans; Hydroxyl Radical; Imidazoles; Leukocytes; Lipid Peroxidation; Pyrazines; Superoxides; Xanthine Oxidase

1996
Capacitation-associated production of superoxide anion by human spermatozoa.
    Free radical biology & medicine, 1995, Volume: 18, Issue:3

    Topics: Humans; Imidazoles; In Vitro Techniques; Kinetics; Luminescent Measurements; Male; Neutrophils; Pyrazines; Reactive Oxygen Species; Sperm Capacitation; Sperm Count; Spermatozoa; Superoxide Dismutase; Superoxides

1995
Continuous detection of superoxide in situ during ischemia and reperfusion in the rabbit heart.
    Japanese heart journal, 1997, Volume: 38, Issue:1

    Topics: Animals; Coronary Circulation; Free Radicals; Hemodynamics; Imidazoles; Luminescent Measurements; Male; Myocardial Reperfusion Injury; Myocardium; Pyrazines; Rabbits; Superoxide Dismutase; Superoxides

1997
Radical production and degranulation in pancreatic islets induced by glucose.
    The Japanese journal of physiology, 1997, Volume: 47 Suppl 1

    Topics: Animals; Cell Degranulation; Glucose; Imidazoles; Islets of Langerhans; Luminescent Measurements; Pyrazines; Rats; Superoxides

1997
1,2-Diacylglycerol hydroperoxides induce the generation and release of superoxide anion from human polymorphonuclear leukocytes.
    FEBS letters, 1997, Aug-04, Volume: 412, Issue:3

    Topics: Diglycerides; Humans; Imidazoles; Lipid Peroxides; Luminescent Measurements; Neutrophils; Phosphatidylcholines; Protein Kinase C; Pyrazines; Superoxides; Tetradecanoylphorbol Acetate

1997
Generation of reactive oxygen species by raphidophycean phytoplankton.
    Bioscience, biotechnology, and biochemistry, 1997, Volume: 61, Issue:10

    Topics: Animals; Catalase; Cell Size; Eukaryota; Hydrogen Peroxide; Hydroxyl Radical; Imidazoles; Luminescent Measurements; Microscopy, Phase-Contrast; Phytoplankton; Pyrazines; Reactive Oxygen Species; Superoxide Dismutase; Superoxides

1997
The antioxidant action of 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-alpha]pyra z in-3-one (MCLA), a chemiluminescence probe to detect superoxide anions.
    FEBS letters, 1998, Jul-03, Volume: 430, Issue:3

    Topics: Amidines; Animals; Antioxidants; Benzene Derivatives; Diphosphates; Free Radical Scavengers; Imidazoles; Iron; Lipid Peroxidation; Liposomes; Luminescent Measurements; Male; Microsomes, Liver; Molecular Probes; Oxygen Consumption; Pyrazines; Rats; Rats, Sprague-Dawley; Superoxides; Thiobarbituric Acid Reactive Substances

1998
Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria.
    The Journal of biological chemistry, 1998, Dec-18, Volume: 273, Issue:51

    Topics: Animals; Cattle; Imidazoles; Indicators and Reagents; Kinetics; Luminescent Measurements; Mitochondria, Heart; Models, Chemical; Oxygen Consumption; Pyrazines; Succinate Cytochrome c Oxidoreductase; Superoxides

1998
Superoxide production from paraquat evoked by exogenous NADPH in pulmonary endothelial cells.
    Free radical biology & medicine, 1999, Volume: 27, Issue:5-6

    Topics: Animals; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Flavoproteins; Imidazoles; Interleukin-1; Luminescent Measurements; Lung; NAD; NADP; Oxidoreductases; Paraquat; Pyrazines; Spectrophotometry; Succinic Acid; Superoxide Dismutase; Superoxides; Swine; Xanthine

1999
Protective effect of nitric oxide against iron-induced neuronal damage.
    Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:9-10

    Topics: Animals; Cell Count; Cerebral Cortex; Ferrous Compounds; Free Radical Scavengers; Imidazoles; Lipid Peroxidation; Male; Neurons; Nitric Oxide Donors; PC12 Cells; Pyrazines; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Time Factors

1999
Involvement of superoxide in acute reaction of angiotensin II in mesenteric microcirculation.
    The Japanese journal of physiology, 1999, Volume: 49, Issue:5

    Topics: Angiotensin II; Animals; Arginine; Enzyme Inhibitors; Imidazoles; Luminescent Measurements; Male; Mesenteric Arteries; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Oxygen; Pyrazines; Rats; Rats, Inbred WKY; Splanchnic Circulation; Superoxide Dismutase; Superoxides; Vasoconstriction; Vasoconstrictor Agents

1999
1,2-Diacylglycerol hydroperoxide induces the generation and release of superoxide anion from human polymorphonuclear leukocytes.
    Advances in experimental medicine and biology, 1999, Volume: 469

    Topics: Diglycerides; Enzyme Inhibitors; Humans; Imidazoles; In Vitro Techniques; Lipid Peroxides; Luminescent Measurements; Neutrophils; Oxidative Stress; Protein Kinase C; Pyrazines; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Type C Phospholipases

1999
Pitfalls of using lucigenin in endothelial cells: implications for NAD(P)H dependent superoxide formation.
    Free radical research, 2000, Volume: 32, Issue:3

    Topics: Acridines; Arsenicals; Cells, Cultured; Cytochrome c Group; Imidazoles; Luminescent Measurements; NAD; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; Neutrophils; Onium Compounds; Pyrazines; Superoxides; Umbilical Veins; Xanthine; Xanthine Oxidase

2000
Galacturonic-acid-induced increase of superoxide production in red tide phytoplankton Chattonella marina and Heterosigma akashiwo.
    Bioscience, biotechnology, and biochemistry, 2000, Volume: 64, Issue:4

    Topics: Culture Media; Hexuronic Acids; Imidazoles; Phytoplankton; Pyrazines; Rhodophyta; Superoxide Dismutase; Superoxides

2000
Prostasomes inhibit the NADPH oxidase activity of human neutrophils.
    Molecular human reproduction, 2000, Volume: 6, Issue:10

    Topics: Cholesterol; Fluorescent Dyes; Humans; Imidazoles; Luminescent Measurements; Male; Membrane Fluidity; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipids; Prostate; Pyrazines; Reactive Oxygen Species; Secretory Vesicles; Semen; Spermatozoa; Temperature; Tetradecanoylphorbol Acetate

2000
Mechanism of superoxide anion generation in the toxic red tide phytoplankton Chattonella marina: possible involvement of NAD(P)H oxidase.
    Biochimica et biophysica acta, 2000, Dec-15, Volume: 1524, Issue:2-3

    Topics: Amino Acid Sequence; Animals; Cell-Free System; Dinoflagellida; Fluorescent Antibody Technique, Indirect; Humans; Imidazoles; Luminescent Measurements; Membrane Glycoproteins; Molecular Sequence Data; NADPH Oxidase 2; NADPH Oxidases; Neutrophils; Plankton; Pyrazines; Sequence Homology, Amino Acid; Superoxides

2000
Inhibitory effect of nicergoline on superoxide generation by activated rat microglias measured using a simple chemiluminescence method.
    Neuroscience letters, 2001, Jan-05, Volume: 297, Issue:1

    Topics: Animals; Cells, Cultured; Imidazoles; Luminescent Measurements; Microglia; Nicergoline; Nootropic Agents; Pyrazines; Rats; Superoxides

2001
Continuous observation of superoxide generation in an in-situ ischemia-reperfusion rat lung model.
    Japanese circulation journal, 2001, Volume: 65, Issue:3

    Topics: Animals; Arterial Occlusive Diseases; Disease Models, Animal; Free Radical Scavengers; Imidazoles; Kinetics; Luminescent Measurements; Lung; Male; Pulmonary Artery; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Superoxides

2001
Detection and cytotoxicity of cisplatin-induced superoxide anion in monolayer cultures of a human ovarian cancer cell line.
    Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:2

    Topics: Antineoplastic Agents; Cell Survival; Cisplatin; Female; Humans; Imidazoles; Luminescent Measurements; Ovarian Neoplasms; Pyrazines; Superoxide Dismutase; Superoxides; Tumor Cells, Cultured

2001
Chemiluminescence of superoxide generated by Candida albicans: differential effects of the superoxide generator paraquat on a wild-type strain and a respiratory mutant.
    Medical mycology, 2002, Volume: 40, Issue:1

    Topics: Candida albicans; Cell Count; Imidazoles; Luminescent Measurements; Mutation; Oxygen Consumption; Paraquat; Pyrazines; Superoxides

2002
Detection of vitamin C-induced singlet oxygen formation in oxidized LDL using MCLA as a chemiluminescence probe.
    Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 2002, Volume: 34, Issue:1

    Topics: Ascorbic Acid; Imidazoles; Lipoproteins, LDL; Luminescent Measurements; Oxygen; Pyrazines

2002
Superoxide anion impairs contractility in cultured aortic smooth muscle cells.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:1

    Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Calcium; Cattle; Cells, Cultured; Collagen; Enzyme Inhibitors; Gels; Imidazoles; Intracellular Fluid; Ionophores; Luminescent Measurements; Muscle, Smooth, Vascular; Potassium; Pyrazines; Superoxide Dismutase; Superoxides; Vasoconstriction; Xanthine; Xanthine Oxidase

2002
Superoxide production in the islet of Langerhans detected by the MCLA chemiluminescence method.
    Methods in molecular biology (Clifton, N.J.), 2002, Volume: 196

    Topics: Animals; Imidazoles; Indicators and Reagents; Islets of Langerhans; Luminescent Measurements; Male; Perfusion; Photons; Pyrazines; Rats; Rats, Wistar; Superoxides

2002
Mechanism of superoxide anion production by hepatic sinusoidal endothelial cells and Kupffer cells during short-term ethanol perfusion in the rat.
    Liver, 2002, Volume: 22, Issue:4

    Topics: Animals; Endothelium, Vascular; Enzyme Inhibitors; Ethanol; Fomepizole; Gadolinium; Ibuprofen; Imidazoles; Kupffer Cells; Luminescent Measurements; Male; Nitroblue Tetrazolium; Onium Compounds; Perfusion; Pyrazines; Pyrazoles; Rats; Rats, Wistar; Staurosporine; Superoxides; tert-Butyl Alcohol

2002
In vivo measurement of superoxide in the cerebral cortex during anoxia-reoxygenation and ischemia-reperfusion.
    The Keio journal of medicine, 2002, Volume: 51, Issue:4

    Topics: Animals; Cats; Cerebral Cortex; Hemodynamics; Imidazoles; Luminescent Measurements; Oxygen; Photons; Pyrazines; Reperfusion Injury; Superoxides; Time Factors

2002
Superoxide radical generation and Mn- and Cu-Zn superoxide dismutases activities in human leukemic cells.
    Hematological oncology, 2003, Volume: 21, Issue:1

    Topics: Adult; Anions; Child; Humans; Imidazoles; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocytes; Manganese; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Oxidative Stress; Oxygen; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrazines; Sodium Dodecyl Sulfate; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Zymosan

2003
Enhanced chemiluminescence of 6-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one by attachment of a cyclomaltooligosaccharide (cyclodextrin). Attachment of cyclomaltononaose (delta-cyclodextrin).
    Carbohydrate research, 2003, Apr-22, Volume: 338, Issue:9

    Topics: Cyclodextrins; Imidazoles; Luminescent Measurements; Molecular Structure; Pyrazines; Spectrometry, Fluorescence

2003
Reestimation of Cypridina luciferin analogs (MCLA) as a chemiluminescence probe to detect active oxygen species--cautionary note for use of MCLA.
    The Journal of toxicological sciences, 2003, Volume: 28, Issue:3

    Topics: Free Radicals; Imidazoles; Luminescent Measurements; Pyrazines; Reactive Oxygen Species

2003
Effects of OPC-6535 on lipopolysaccharide-induced acute liver injury in the rat: involvement of superoxide and tumor necrosis factor-alpha from hepatic macrophages.
    Surgery, 2003, Volume: 134, Issue:5

    Topics: Animals; Chemokine CXCL1; Chemokines, CXC; Imidazoles; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver; Luminescent Measurements; Macrophages; Male; Nitroblue Tetrazolium; Perfusion; Peroxidase; Pyrazines; Rats; Rats, Wistar; Superoxides; Thiazoles; Tumor Necrosis Factor-alpha

2003
Cyclodextrin-bound 6-(4-methoxyphenyl)imidazo[1,2-alpha+/-]pyrazin-3(7H)-ones with fluorescein as green chemiluminescent probes for superoxide anions.
    Analytical biochemistry, 2004, Feb-15, Volume: 325, Issue:2

    Topics: Cyclodextrins; Fluorescein; Imidazoles; Luminescence; Molecular Probes; Pyrazines; Superoxides

2004
Chemiluminescent visualization of superoxide generated by Candida albicans.
    Medical mycology, 2004, Volume: 42, Issue:5

    Topics: Candida albicans; Culture Media; Imidazoles; Luminescent Measurements; Motion Pictures; Mutation; Oxygen Consumption; Paraquat; Photons; Pyrazines; Superoxides

2004
Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa.
    Biology of reproduction, 2005, Volume: 73, Issue:2

    Topics: Acridines; Animals; Blotting, Western; Chlorocebus aethiops; Coloring Agents; COS Cells; Cytochrome-B(5) Reductase; Humans; Imidazoles; Luminescent Measurements; Male; NAD; Oxidation-Reduction; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spectrometry, Fluorescence; Spermatozoa; Tetrazolium Salts; Transfection

2005
Determination of superoxide in seawater using 2-methyl-6-(4-methoxyphenyl)-3,7- dihydroimidazo[1,2-a]pyrazin-3(7H)-one chemiluminescence.
    Analytical chemistry, 2008, Feb-15, Volume: 80, Issue:4

    Topics: Hydrogen-Ion Concentration; Imidazoles; Luminescence; Luminescent Measurements; Metals; Oxygen; Pacific Ocean; Photochemistry; Pyrazines; Seawater; Superoxides; Time Factors; Xanthine; Xanthine Oxidase

2008
Application of a superoxide (O(2)(-)) thermal source (SOTS-1) for the determination and calibration of O(2)(-) fluxes in seawater.
    Analytica chimica acta, 2010, May-14, Volume: 667, Issue:1-2

    Topics: Benzoates; Calibration; Cytochromes c; Imidazoles; Kinetics; Luminescent Measurements; Nitrites; Oxidation-Reduction; Photochemical Processes; Pyrazines; Seawater; Superoxides; Temperature

2010
Sulfur-containing compounds quench 3,7-dihydro-2-methyl-6-(4-methoxyphenyl)imidazol[1,2-a]pyrazine-3-one chemiluminescence: Discrimination between true antioxidants and quenchers using xanthine oxidase.
    Analytical biochemistry, 2010, Nov-15, Volume: 406, Issue:2

    Topics: Antioxidants; Imidazoles; Luminescent Measurements; Pyrazines; Sulfur Compounds; Xanthine Oxidase

2010
Pyridine nucleotides regulate the superoxide anion flash upon permeabilization of mitochondrial membranes: An MCLA-based study.
    Free radical biology & medicine, 2018, 08-20, Volume: 124

    Topics: Animals; Imidazoles; Male; Mitochondrial Membranes; NADP; Permeability; Pyrazines; Pyridines; Rats; Rats, Wistar; Superoxides

2018
Rapid on-site dual optical system to measure specific reactive oxygen species (O2-• and OCl-) in a tiny droplet of whole blood.
    PloS one, 2018, Volume: 13, Issue:8

    Topics: Aniline Compounds; Area Under Curve; Diet; Exercise; Fluoresceins; HL-60 Cells; Humans; Hypochlorous Acid; Imidazoles; Luminescent Measurements; Neutrophils; Peroxidase; Pyrazines; ROC Curve; Singlet Oxygen

2018
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.
    Nature cancer, 2022, Volume: 3, Issue:4

    Topics: Antibodies, Bispecific; ErbB Receptors; Humans; Imidazoles; Neoplasms, Glandular and Epithelial; Neoplastic Stem Cells; Organoids; Pyrazines; Receptors, G-Protein-Coupled

2022
A Patient-Derived Organoid Screen Identified the Bispecific Antibody MCLA-158.
    Cancer discovery, 2022, 07-06, Volume: 12, Issue:7

    Topics: Antibodies, Bispecific; Cell Proliferation; Humans; Imidazoles; Neoplasms; Organoids; Pyrazines

2022