pyrazines has been researched along with 2-(allylthio)pyrazine in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (69.23) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, ND; Kim, SG; Kwak, MK | 1 |
| Kang, KW; Kim, ND; Kim, SG; Schini-Kerth, VB | 1 |
| Kim, ND; Kim, SG; Lee, AK | 1 |
| Kim, ND; Kwak, MK; Lee, MG; Lee, WI | 1 |
| Han, KS; Koo, CH; Lee, MG; Woo, SJ | 3 |
| Kim, ND; Kim, SG; Lee, JM; Miller, JA; Park, KK; Sohn, Y; Surh, YJ | 1 |
| Cho, CK; Kim, CW; Kim, ND; Kim, SG; Nam, SY | 1 |
| Ha, TG; Kim, ND | 1 |
| Han, KS; Lee, MG | 2 |
| Kim, ND; Kim, SG | 1 |
| Cho, MK; Choi, SH; Kim, HJ; Kim, ND; Kim, SG; Kwak, MK | 1 |
| Ha, TG; Jang, JJ; Kim, ND; Kim, SG | 1 |
| Kim, HJ; Kim, ND; Kong, G; Lee, SJ; Surh, YJ | 1 |
| Ha, TG; Kim, ND; Kim, SG; Mar, WC; Surh, YJ | 1 |
| Kim, DH; Lee, DH | 1 |
| Bu, S; Kim, S; Kim, Y; Lee, M | 1 |
| Kim, ND; Lee, B; Lee, JW | 1 |
| Ahn, B; Choi, KS; Kang, JS; Kim, DJ; Kim, KS; Kim, ND; Park, KH; Surh, YJ | 1 |
| Ha, JR; Kang, KW; Kim, CW; Kim, ND; Kim, SG | 1 |
| Cho, MK; Kim, DH; Kim, SG; Kwon, JW; Lee, MG; Yim, YG | 1 |
| Chung, HC; Kim, DH; Kim, EJ; Kim, SG; Kim, SH; Kim, YG; Lee, EJ; Lee, I; Lee, MG | 1 |
| Chung, HC; Kim, DH; Kim, EJ; Kim, SG; Kim, SH; Kim, YG; Lee, EJ; Lee, MG; Lees, I | 1 |
| Choi, HG; Jang, JH; Kim, CK; Sung, JH | 1 |
1 review(s) available for pyrazines and 2-(allylthio)pyrazine
| Article | Year |
|---|---|
Chemopreventive effects of 2-(allylthio)pyrazine.
Topics: Animals; Anticarcinogenic Agents; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Glutathione; Humans; Liver; Pyrazines; Radiation-Protective Agents | 1999 |
25 other study(ies) available for pyrazines and 2-(allylthio)pyrazine
| Article | Year |
|---|---|
Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors; Female; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1997 |
Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Enzyme Inhibitors; Lipopolysaccharides; Male; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Organ Culture Techniques; Phenylephrine; Pyrazines; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 1997 |
Partial hepatoprotective effects of allylthiobenzimidazole in the absence of cytochrome P4502E1 suppression: effects on epoxide hydrolase, rGSTA2, rGSTA3/5, rGSTM1 and rGSTM2 expression.
Topics: Animals; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; Glutathione Transferase; Liver; Male; Mice; Microsomes, Liver; Pyrazines; Rats; Rats, Sprague-Dawley | 1998 |
Metabolic changes of acetaminophen after intravenous administration to rats pretreated with 2-(allylthio)pyrazine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Inactivation, Metabolic; Male; Pyrazines; Rats; Rats, Sprague-Dawley | 1998 |
Pharmacokinetics of a chemoprotective agent, 2-(allylthio)pyrazine, after intravenous administration to rabbits.
Topics: Animals; Area Under Curve; Bile; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Feces; Half-Life; Infusions, Intravenous; Male; Pyrazines; Rabbits | 1998 |
Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Enzyme Inhibitors; Female; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred ICR; Mutagens; Pyrazines; Rats; Rats, Sprague-Dawley; Urethane | 1998 |
Determination of a chemoprotective agent, 2-(allylthio)pyrazine, in plasma, urine and tissue homogenates by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors; Humans; Male; Protective Agents; Pyrazines; Rats; Rats, Sprague-Dawley | 1998 |
Stability, blood partition, and protein binding of a chemoprotective agent, 2-(allylthio)pyrazine.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Enzyme Inhibitors; Gastric Juice; Humans; Hydrogen-Ion Concentration; Pyrazines; Rabbits; Serum Albumin | 1998 |
Radioprotective effects of 2-(allylthio)pyrazine an experimental chemopreventive agent: effects on detoxifying enzyme induction.
Topics: Animals; Enzyme Induction; Enzyme Inhibitors; Epoxide Hydrolases; Glutathione Transferase; Liver; Male; Mice; Mice, Inbred ICR; Pyrazines; Radiation Injuries, Experimental; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley | 1998 |
2-(allylthio)pyrazine inhibition of aflatoxin B1-induced hepatotoxicity in rats: inhibition of cytochrome P450 2B- and 3A2-mediated bioactivation.
Topics: Aflatoxin B1; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; DNA Adducts; Enzyme Inhibitors; Lipid Peroxidation; Liver; Liver Function Tests; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Transaminases | 1998 |
Pharmacokinetics of a chemoprotective agent, 2-(allylthio)pyrazine, after intravenous and oral administration to rats: hepatic and gastric first-pass effects.
Topics: Administration, Oral; Animals; Area Under Curve; Duodenum; Enzyme Inhibitors; Gastric Mucosa; Injections, Intravenous; Liver; Male; Portal Vein; Pyrazines; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1999 |
Molecular basis for hepatic detoxifying enzyme induction by 2-(allylthio)pyrazine in rats in comparison with oltipraz: effects on prooxidant production and DNA degradation.
Topics: Animals; Antioxidants; Blotting, Northern; Buthionine Sulfoximine; Cysteine; Cytochrome P-450 CYP2E1 Inhibitors; DNA Damage; Enzyme Induction; Enzyme Inhibitors; Epoxide Hydrolases; Glutathione; Glutathione Transferase; Immunoblotting; Inactivation, Metabolic; Liver; Male; Microsomes, Liver; NF-kappa B; Oxidants; Pyrazines; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Thiones; Thiophenes | 1999 |
Effect of a new chemoprotective agent, 2-(allylthio)pyrazine, on the pharmacokinetics of intravenous theophylline in rats.
Topics: Animals; Area Under Curve; Biotransformation; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Infusions, Intravenous; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Theophylline | 1999 |
2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats.
Topics: Aflatoxin B1; Animals; Carcinogenicity Tests; DNA Adducts; DNA, Neoplasm; Enzyme Inhibitors; Glutathione Transferase; Hepatectomy; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; RNA | 1999 |
Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by 2-(allylthio) pyrazine.
Topics: Anticarcinogenic Agents; Cell Differentiation; Cyclin D; Cyclin E; Cyclins; Down-Regulation; Granulocytes; HL-60 Cells; Humans; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyrazines | 1999 |
Enhancement of biliary excretion of aflatoxin B(1) and suppression of hepatic ornithine decarboxylase activity by 2-(allylthio)pyrazine in rats.
Topics: Aflatoxin B1; Animals; Bile; Biliary Tract; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Enzyme Inhibitors; Glutathione; Liver; Male; Ornithine Decarboxylase Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley | 1999 |
S-methylation of 2-mercaptopyrazine in rat liver microsomes and cytosol.
Topics: Aniline Compounds; Animals; Benzylamines; Chlorobenzoates; Cytosol; Enzyme Inhibitors; Male; Methylation; Methyltransferases; Microsomes, Liver; Proadifen; Pyrazines; Rats; Rats, Sprague-Dawley; Vanillic Acid | 1999 |
Effects of enzyme inducers and inhibitor on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats.
Topics: Amines; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Isoniazid; Male; Phenobarbital; Proadifen; Pyrazines; Rats; Rats, Sprague-Dawley | 2000 |
Synthesis of 2-(allylthio)pyrazines as a novel cancer chemopreventive agent.
Topics: Anticarcinogenic Agents; Enzyme Inhibitors; Neoplasms; Pyrazines | 2001 |
Chemopreventive effect of 2-(allylthio)pyrazine (2-AP) on rat colon carcinogenesis induced by azoxymethane (AOM).
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Enzyme Inhibitors; Intestinal Mucosa; Male; Organ Size; Pyrazines; Rats; Rats, Inbred F344 | 2001 |
2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.
Topics: Animals; Dimethylnitrosamine; Enzyme Inhibitors; Liver; Liver Cirrhosis; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transaminases; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Effects of cysteine on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats with protein-calorie malnutrition.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Cysteine; Eating; Injections, Intravenous; Male; Organ Size; Protective Agents; Protein-Energy Malnutrition; Pyrazines; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2003 |
Pharmacokinetic changes of intravenous 2-(allylthio) pyrazine, a chemoprotective agent, in rats with acute renal failure induced by uranyl nitrate.
Topics: Acute Kidney Injury; Albumins; Animals; Area Under Curve; Blood Urea Nitrogen; Chromatography, High Pressure Liquid; Creatinine; Enzyme Inhibitors; Half-Life; Injections, Intravenous; Male; Organ Size; Proteins; Pyrazines; Rats; Rats, Sprague-Dawley; Uranyl Nitrate | 2002 |
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of 2-(allylthio) pyrazine, a chemoprotective agent, in rats: the role of CYP3A23 induction.
Topics: Acute Kidney Injury; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Enzyme Induction; Kinetics; Male; Organometallic Compounds; Pyrazines; Rats; Rats, Sprague-Dawley | 2004 |
Preparation and evaluation of 2-(allylthio)pyrazine-loaded lipid emulsion with enhanced stability and liver targeting.
Topics: Animals; Drug Carriers; Drug Delivery Systems; Drug Stability; Enzyme Inhibitors; Fat Emulsions, Intravenous; Lecithins; Liver; Male; Particle Size; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility; Soybean Oil; Tissue Distribution | 2009 |