pyrazines has been researched along with 1-methyl-3-isobutylxanthine in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 10 (58.82) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A | 1 |
| Iijima, T; Taira, N | 1 |
| Bryson, SE; Rodger, IW | 1 |
| Reeves, ML; Rink, TJ; Simpson, AW | 1 |
| Brown, AM; Hill, SJ; Stanley, C | 1 |
| Barnette, M; Grous, M | 1 |
| Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Ando, H; Ando, S; Nomura, H; Takeya, K; Yajima, M | 1 |
| Harding, SE; Poole-Wilson, PA; Wynne, DG | 1 |
| Furman, BL; Pyne, NJ; Shafiee-Nick, R | 1 |
| Bonnet, PA; Chevillard, C; Michel, A; Vittet, D; Zurbonsen, K | 1 |
| Bonnet, PA; Crilley, TK; Wanstall, JC | 1 |
| Jeffery, TK; Wanstall, JC | 1 |
| Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M | 1 |
| Keravis, T; Le Bec, A; Lugnier, C; Pauvert, O; Proteau, S; Rousseau, E | 1 |
| Chen, L; Huang, F; Li, W; Li, X; Liu, Z; Luo, Z; Wu, H; Xu, Y; Young, C; Zhou, S | 1 |
| Islam, MS; Jisaka, M; Khan, F; Nartey, MN; Nishimura, K; Rahman, MS; Shono, F; Syeda, PK; Yokota, K | 1 |
17 other study(ies) available for pyrazines and 1-methyl-3-isobutylxanthine
| Article | Year |
|---|---|
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles | 1979 |
Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium; Electric Conductivity; Guinea Pigs; Heart; Myocardial Contraction; Myocardium; Potassium; Pyrazines; Quinolines | 1987 |
Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Airway Resistance; Animals; Cyclic AMP; Cyclic GMP; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyrazines | 1987 |
Effects of SK&F 94120, an inhibitor of cyclic nucleotide phosphodiesterase type III, on human platelets.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenosine Diphosphate; Blood Platelets; Collagen; Cyclic AMP; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyrazines | 1988 |
Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cerebral Cortex; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine; Isoenzymes; Male; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1989 |
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antigens; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Immunization; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1994 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Relaxing effect of vesnarinone (OPC-8212) on the tracheal muscle strips isolated from guinea pigs.
Topics: 1-Methyl-3-isobutylxanthine; Airway Resistance; Animals; Carbachol; Drug Interactions; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Potassium; Propranolol; Pyrazines; Quinolines; Reserpine; Trachea | 1993 |
Incomplete reversal of beta-adrenoceptor desensitization in human and guinea-pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Guanidines; Guinea Pigs; Heart; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Norepinephrine; Pyrazines; Pyridazines | 1993 |
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes | 1995 |
Antiproliferative effects of imidazo[1,2-a]pyrazine derivatives on the Dami cell line.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Division; Cell Survival; Cyclic AMP; Imidazoles; Phosphoric Diester Hydrolases; Pyrazines; Pyridazines; Receptors, Purinergic P2; Tumor Cells, Cultured | 1997 |
Vasorelaxant effects of SCA40 (a phosphodiesterase III inhibitor) in pulmonary vascular preparations in rats.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Guinea Pigs; Imidazoles; Male; Milrinone; Muscle, Smooth, Vascular; Parasympatholytics; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Pulmonary Artery; Pyrazines; Pyridones; Rats; Rats, Wistar; Trachea; Vasodilation; Vasodilator Agents | 1998 |
Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Hypertension, Pulmonary; Hypoxia; Imidazoles; Male; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Pyrazines; Pyridones; Rats; Rats, Wistar; Vasodilation | 1998 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Nucleus; Chromatography, High Pressure Liquid; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Ventricles; Intracellular Membranes; Isoenzymes; Myocardium; Pyrazines; Rolipram; Sheep | 1999 |
The novel compound liguzinediol exerts positive inotropic effects in isolated rat heart via sarcoplasmic reticulum Ca2+ ATPase-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart; Male; Myocardial Contraction; Myocytes, Cardiac; Nimodipine; Ouabain; Prazosin; Propranolol; Pyrazines; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin | 2012 |
Pretreatment of cultured preadipocytes with arachidonic acid during the differentiation phase without a cAMP-elevating agent enhances fat storage after the maturation phase.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; 6-Ketoprostaglandin F1 alpha; Acetates; Adipocytes; Adipogenesis; Animals; Arachidonic Acid; Cell Differentiation; Cells, Cultured; Cyclic AMP; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Gene Expression Regulation; Humans; Hydroxyprostaglandin Dehydrogenases; Membrane Proteins; Mesenchymal Stem Cells; Mice; Prostaglandin-E Synthases; Pyrazines; Receptors, Prostaglandin; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Triglycerides | 2016 |