pyrazines has been researched along with 1,2-dithiol-3-thione in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Curphey, TJ; Eaton, DL; Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| DeMatos, P; Egner, PA; Groopman, JD; Kensler, TW; Love-Hunt, A | 1 |
| Dolan, PM; Egner, PA; Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Fardel, O; Gilmore, KS; Guillouzo, A; Kensler, TW; Ketterer, B; Langouet, S; Meunier, B; Meyer, DJ; Morel, F; Tu, CP | 1 |
| Coles, B; Gilmore, KS; Harris, JM; Kensler, TW; Ketterer, B; Meyer, DJ | 1 |
| Gates, KS; Kim, W | 1 |
| Furge, LL; Guengerich, FP; Guillouzo, A; Kerriguy, N; Langouët, S; Nakamura, K | 1 |
| Arif, JM; Gupta, RC; Smith, WA | 1 |
| Freeman, JW; Gupta, RC; Smith, WA | 1 |
| Dolan, PM; Egner, PA; Groopman, JD; Itoh, K; Kensler, TW; Kwak, MK; Ramos-Gomez, M; Yamamoto, M | 1 |
| Chan, JY; Pietsch, EC; Torti, FM; Torti, SV | 1 |
| Chun, JA; Furge, LL; Haab, BB; Haddad, R; Klenow, S; Konwinski, RR; Larson, SC | 1 |
| Li, J; Munday, CM; Munday, R; Zhang, Y | 1 |
| George, EO; Goodwin, SB; Jin, VX; Kensler, TW; Phan, V; Rahman, M; Roebuck, BD; Sutter, CH; Sutter, TR; Tran, QT; Xu, L | 1 |
| Fishbein, JC; Holland, R; Kensler, TW; Navamal, M; Velayutham, M; Zweier, JL | 1 |
| Bhattacharyya, S; Gates, KS; Seiner, DR; Zhou, H | 1 |
| Kim, SG; Lee, JM; Lee, YH; Lee, YS | 1 |
| Bao, K; Li, M; Lu, G; Qi, H; Shen, Q; Wang, Z; Wu, Y; Zhang, W | 1 |
1 review(s) available for pyrazines and 1,2-dithiol-3-thione
| Article | Year |
|---|---|
Role of phase 2 enzyme induction in chemoprotection by dithiolethiones.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Carcinogens; Chemoprevention; China; Controlled Clinical Trials as Topic; Enzyme Induction; Gene Expression; Glucuronosyltransferase; Glutathione Transferase; Humans; Inactivation, Metabolic; Liver Neoplasms; Pyrazines; Quinone Reductases; Thiones; Thiophenes | 2001 |
17 other study(ies) available for pyrazines and 1,2-dithiol-3-thione
| Article | Year |
|---|---|
Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1992 |
Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Biomarkers; DNA; Guanine; Liver Neoplasms, Experimental; Male; Protein Binding; Pyrazines; Rats; Rats, Inbred F344; Serum Albumin; Thiones; Thiophenes | 1992 |
Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antineoplastic Agents; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Heterocyclic Compounds; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiones; Thiophenes | 1987 |
Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.
Topics: Cells, Cultured; Enzyme Induction; Gene Expression; Glutathione Transferase; Humans; Liver; Methylcholanthrene; Phenobarbital; Pyrazines; RNA, Messenger; Thiones; Thiophenes | 1993 |
Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones.
Topics: Animals; Antineoplastic Agents; Enzyme Induction; Female; Glutathione Transferase; Intestine, Small; Kidney; Lung; Male; Organ Specificity; Pyrazines; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stomach; Thiones; Thiophenes | 1993 |
Evidence for thiol-dependent production of oxygen radicals by 4-methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz) and 3H-1,2-dithiole-3-thione: possible relevance to the anticarcinogenic properties of 1,2-dithiole-3-thiones.
Topics: Anaerobiosis; Anticarcinogenic Agents; Buffers; Chelating Agents; Chemical Phenomena; Chemistry, Physical; DNA Damage; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Free Radicals; Plasmids; Pyrazines; Sulfhydryl Compounds; Thiones; Thiophenes | 1997 |
Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.
Topics: Anticarcinogenic Agents; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Humans; Isothiocyanates; Pyrazines; Quinolines; Sulfoxides; Thiocyanates; Thiones; Thiophenes | 2000 |
1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenz.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzopyrenes; Body Weight; Chromatography; DNA Adducts; Female; Liver; Lung; Mammary Glands, Animal; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2001 |
Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7.
Topics: Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents; Benzopyrenes; Breast; Breast Neoplasms; Carcinogens; Cell Line; Chemoprevention; Chlorophyllides; DNA Adducts; Dose-Response Relationship, Drug; Female; Humans; Pyrazines; Thiones; Thiophenes | 2001 |
Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.
Topics: 3T3 Cells; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Base Sequence; beta-Naphthoflavone; Blotting, Northern; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Ferritins; Gene Deletion; Genes, Reporter; Humans; Iron; Mice; Models, Biological; Models, Genetic; Molecular Sequence Data; NF-E2-Related Factor 2; Plasmids; Protein Binding; Protein Structure, Tertiary; Pyrazines; Response Elements; Thiones; Thiophenes; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Xenobiotics | 2003 |
Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells.
Topics: Animals; Antioxidants; Blotting, Western; Cell Line; Cells, Cultured; DNA, Complementary; Hydrogen Peroxide; Isothiocyanates; Lipopolysaccharides; Mice; Microglia; Microscopy, Fluorescence; Oligonucleotide Array Sequence Analysis; Oxidants; Oxidative Stress; Pyrazines; Reactive Oxygen Species; RNA; Stimulation, Chemical; Sulfoxides; Thiocyanates; Thiones; Thiophenes | 2004 |
Structure-activity relationships in the induction of Phase II enzymes by derivatives of 3H-1,2-dithiole-3-thione in rats.
Topics: Animals; Antineoplastic Agents; Enzyme Induction; Female; Glutathione Transferase; Metabolic Detoxication, Phase II; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiones; Thiophenes | 2006 |
Chemical genomics of cancer chemopreventive dithiolethiones.
Topics: Animals; Anticarcinogenic Agents; Cytochrome P-450 CYP1A2; Gene Expression Profiling; Genomics; Glutathione; Heterocyclic Compounds, 1-Ring; Liver; Male; Multigene Family; NF-E2-Related Factor 2; Oligonucleotide Array Sequence Analysis; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiones; Thiophenes | 2009 |
Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cyclic N-Oxides; Diglycerides; Enzyme Induction; Hepatocytes; Humans; Hydrogen Peroxide; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Pyrazines; Second Messenger Systems; Thiones; Thiophenes | 2009 |
Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.
Topics: Anticarcinogenic Agents; Catalytic Domain; Humans; Mass Spectrometry; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrazines; Reactive Oxygen Species; Recombinant Proteins; Thiones; Thiophenes | 2010 |
Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor.
Topics: Antineoplastic Agents; Glucose Transporter Type 1; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Pyrazines; Thiones; Thiophenes; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2016 |
4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin.
Topics: Antineoplastic Agents; Bibenzyls; Cell Cycle; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; KB Cells; Molecular Docking Simulation; Protein Multimerization; Protein Structure, Quaternary; Pyrazines; Structure-Activity Relationship; Thiones; Thiophenes; Tubulin; Tubulin Modulators | 2016 |