pyrazinamide has been researched along with probenecid in 110 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 75 (68.18) | 18.7374 |
1990's | 23 (20.91) | 18.2507 |
2000's | 6 (5.45) | 29.6817 |
2010's | 6 (5.45) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
Cadenhead, A; Cameron, JS; Hatfield, PJ; Simmonds, HA | 1 |
Bohn, DL; Fanelli, GM; Zacchei, AG | 1 |
Fanelli, GM; Weiner, IM | 2 |
Boss, GR; Seegmiller, JE | 1 |
Weiner, IM | 1 |
Diamond, HS; Holden, D; Meisel, AD | 1 |
Barrientos, A; Diaz-Gonzalez, R; Perez-Diaz, V; Rodicio, JL | 1 |
Frank, M; Many, M; Sperling, O | 1 |
de Vries, A; Sperling, O | 1 |
Deetjen, P; Greger, R; Lang, F; Oberleithner, H | 1 |
Benjamin, D; Pinkhas, J; Sperling, O; Weinberg, A | 1 |
Benjamin, D; de Vries, A; Pinkhas, J; Sperling, O; Weinberger, A | 3 |
Fannelli, GM; Weiner, IM | 1 |
Diamond, HS; Meisel, AD | 4 |
Akaoka, I; Kamtani, N; Nishida, Y; Nishizawa, T; Sasaki, S; Yano, E | 1 |
Berger, L; Dayton, PG; Israili, ZH; Perel, J; Roboz, J; Yü, TF | 1 |
Akaoka, I; Kawabe, K; Murayama, T | 1 |
Cacatian, A; Diamond, HS; Holden, D; Meisel, A; Sharon, E | 1 |
Jung, DK; Jung, JS; Kim, YK; Lee, SH | 1 |
Hisatome, I; Ishimura, M; Kosaka, H; Kotake, H; Kouchi, T; Mitani, Y; Sasaki, N; Tanaka, Y; Yamakawa, M; Yoshida, A | 1 |
Kawachi, M; Kiyokawa, H; Kono, N; Kuwajima, M; Mineo, I; Nakajima, H; Shimizu, T; Tarui, S; Yorifuji, S | 1 |
Katinios, A; Magoula, I; Mavromatidis, K; Tsapas, G | 1 |
Hisatome, I; Kobayashi, M; Kosaka, H; Kotake, H; Mashiba, H; Sasaki, N; Takeda, A; Tanaka, Y; Yamakawa, M; Yoshida, A | 1 |
Kountouras, I; Kountouras, J; Magoula, I; Paletas, K; Tsapas, G | 1 |
Guisan, B; Roch-Ramel, F; Werner, D | 1 |
Kawachi, M; Kiyokawa, H; Kono, N; Kuwajima, M; Mineo, I; Nakajima, H; Nishimura, T; Ono, A; Shimizu, T; Yorifuji, S | 1 |
Shinosaki, T; Yonetani, Y | 2 |
Higashino, K; Moriwaki, Y; Suda, M; Takahashi, S; Yamamoto, T | 1 |
Magoula, I; Mavromatidis, K; Paletas, K; Tsapas, G | 1 |
Meyer, EC; Moncrieff, J; Sommers, DK | 1 |
Hirata, Y; Itoh, H; Iwamoto, H; Marumo, F; Shichiri, M | 1 |
Rauer, S; Schollmeyer, P | 1 |
MacDougall, ML; Wiegmann, TB | 1 |
Hada, T; Higashino, K; Moriwaki, Y; Takahashi, S; Yamamoto, T | 3 |
Goto, H; Ito, A; Mikami, T | 1 |
Frydman, M; Gafter, U; Levi, J; Lewinski, UH; Zuta, A | 1 |
Kahn, AM; Weinman, EJ | 1 |
Colussi, G; De Ferrari, ME; Malberti, F; Minetti, L; Rolando, P; Rombolà, G; Surian, M | 1 |
Colussi, G; De Ferrari, ME; Minetti, L; Rombolà, G | 1 |
Kateruttanakul, P; Sitprija, V; Tungsanga, K | 1 |
Iwamoto, H; Kanayama, M; Maeda, M; Shichiri, M; Shiigai, T | 1 |
Schoeman, HS; Sommers, DK | 1 |
Garyfallos, A; Magoula, I; Tsapas, G | 1 |
Bidiville, J; Roch-Ramel, F | 1 |
Aihara, E; Hayama, T; Kokue, E; Koyanagi, M; Shimoda, M | 1 |
Conthe Gutiérrez, P; García Puig, J; López Jiménez, M; Mateos Antón, F | 1 |
Iwamoto, H; Shichiri, M; Shiigai, T | 2 |
Gomi, M; Iida, S; Kono, N; Moriwaki, K; Nakajima, H; Tarui, S | 1 |
Atanes García, C; Ferrón Vidan, F; Larrañaga, JR; Mardomingo Varela, P; Pousa Estévez, L | 1 |
Bar-Khayim, Y; Smetana, SS | 1 |
Gougoux, A; Lemieux, G; Michaud, G; Vinay, P | 1 |
Danovitch, GM | 1 |
Auscher, C; de Gery, A; Delbarre, F; Saporta, L | 1 |
De Vries, A; Liberman, UA; Oliver, I; Sperling, O; Weinberger, A | 1 |
Boner, G; Steele, TH | 1 |
Diamond, HS; Paolino, JS | 1 |
Healey, LA; Simkin, PA; Skeith, MD | 1 |
Holmes, EW; Kelley, WN | 1 |
Diamond, HS; Sharon, E | 1 |
Amiel, C; Paillard, F; Podevin, R; Richet, G | 1 |
Branham, S; Kahn, AM; Weinman, EJ | 1 |
Iwaki, K; Yonetani, Y | 1 |
Geibel, J; Lang, F; Rehwald, W; Völkl, H | 1 |
Garcia Puig, J; Gaspar, G; Lesmes, A; Mateos Antón, F; Muñoz Sanz, A; Ortiz Vázquez, J; Ramos, T | 1 |
Gaspar, G; Gijón Baños, J; Mateos, F; Muñoz, A; Puig, JG; Ramos, T | 1 |
Homma, Y; Kitamura, T; Nishimura, Y | 1 |
Abe, H; Fujiwara, Y; Orita, Y; Takamitsu, Y; Ueda, N | 1 |
Barbado, FJ; García Puig, J; Mateos, F; Muñoz Sanz, A | 1 |
Aonuma, K; Ito, Y; Matsuda, O; Shiigai, T; Takeuchi, J | 1 |
Kanayama, M; Matsuda, O; Shichiri, M; Shiigai, T; Takeuchi, J | 1 |
Arnalich, F; Barbado, FJ; García Puig, J; Muñoz Sanz, A; Peña, JM; Redondo, C; Vázquez, JJ | 1 |
Borden, M; Kaufman, IA; Nyhan, WL; Stapleton, FB | 1 |
Roch-Ramel, F; Schäli, C | 2 |
Simkin, PA | 1 |
Estepa, MR; Gallego, N; Gámez, C; Marcén, R; Orofino, L; Ortuño, J; Sabater, J; Teruel, JL | 1 |
Hiroshige, K; Kuroiwa, A; Takasugi, M; Yuu, K | 1 |
Kawai, S; Osawa, G; Yamada, M | 1 |
Jankowska, I; Januszewicz, P; Moszczyńska, A; Zawadzki, J | 1 |
Fujimoto, Y; Hirata, N; Hisatome, I; Kosaka, H; Kotake, H; Mashiba, H; Sato, R; Shigemasa, C; Tanaka, Y; Yoshida, A | 1 |
Brimioulle, S; Decaux, G; Prospert, F; Soupart, A | 1 |
Fujimoto, Y; Hisatome, I; Igawa, O; Kosaka, H; Manabe, I; Ohtahara, A; Ohtahara, K; Sawaguchi, M; Shigemasa, C; Takeda, A; Tanaka, Y; Tsuboi, M; Yoshida, A | 1 |
Diezi, J; Guisan, B; Roch-Ramel, F | 1 |
Hamada, N; Hiroe, K; Hisatome, I; Kato, T; Kinugawa, T; Manabe, I; Ogino, K; Ohtahara, A; Sato, R; Shigemasa, C; Shimoyama, M; Takeda, A; Tanaka, Y; Tsuboi, M; Yamamoto, Y; Yoshida, A | 1 |
Decaux, G; Hannotier, P; Musch, W; Prospert, F; Soupart, A | 1 |
Abe, T; Oda, Y; Watanabe, T | 1 |
Endou, H; Hosoya, T; Hosoyamada, M; Ichida, K; Kimura, H; Takeda, M; Utsunomiya, Y | 1 |
Hosoyamada, M; Ichida, K | 1 |
EISENBERG, GM; FLIPPIN, HF; KAPLAN, A; WEISS, W | 1 |
BYWATERS, EG; DIXON, AS; SCOTT, JT | 1 |
NECHAY, BR; NECHAY, L | 1 |
Adachi, M; Endou, H; Hosoyamada, M; Itoh, K; Kitamura, K; Matsushita, K; Nonoguchi, H; Tanaka, M; Tomita, K; Wakita, N | 1 |
Hirano, T; Iseki, K; Itagaki, S; Kobayashi, M; Miyazaki, K; Shimamoto, S; Sugawara, M | 1 |
6 review(s) available for pyrazinamide and probenecid
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Hyperuricemia and gout. Classification, complications and management.
Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Indomethacin; Kidney; Kidney Calculi; Kidney Diseases; Lead Poisoning; Lymphoproliferative Disorders; Myeloproliferative Disorders; Phenylbutazone; Platelet Aggregation; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Uricosuric Agents | 1979 |
Urate transport in the nephron.
Topics: Animals; Biological Transport, Active; Glucose; Humans; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Mersalyl; p-Aminohippuric Acid; Permeability; Probenecid; Pyrazinamide; Uric Acid | 1979 |
Urate transport in the proximal tubule: in vivo and vesicle studies.
Topics: Absorption; Animals; Basement Membrane; Bicarbonates; Biological Transport, Active; Chlorides; Dogs; Humans; Hydroxides; Hydroxyl Radical; Infant, Newborn; Isomerism; Kidney Tubules, Proximal; Lactates; Lactic Acid; Microvilli; Models, Biological; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats; Species Specificity; Uric Acid | 1985 |
Uric acid transport in renal failure. A review.
Topics: Absorption; Biological Transport; Depression, Chemical; Homeostasis; Humans; Kidney; Kidney Failure, Chronic; Kidney Tubules; Nephrons; Probenecid; Protein Binding; Pyrazinamide; Uric Acid | 1972 |
[Molecular mechanism for urinary excretion of hypoxanthine and xanthine].
Topics: Animals; Benzbromarone; Biological Transport; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Kidney; Membrane Transport Proteins; Probenecid; Pyrazinamide; Uricosuric Agents; Xanthine | 2003 |
2 trial(s) available for pyrazinamide and probenecid
Article | Year |
---|---|
Effects of pyrazinamide, probenecid, and benzbromarone on renal excretion of oxypurinol.
Topics: Adult; Benzbromarone; Biological Transport; Humans; Kidney; Male; Oxypurinol; Probenecid; Pyrazinamide | 1991 |
Treatment of gout and hyperuricaemia by benzbromarone, ethyl 2 (dibromo-3,5 hydroxy-4 benzoyl)-3 benzofuran.
Topics: Benzoates; Bromine; Clinical Trials as Topic; Creatinine; Gout; Humans; Hypoxanthines; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Uric Acid; Xanthines | 1974 |
102 other study(ies) available for pyrazinamide and probenecid
Article | Year |
---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Uric acid excretion by the pig kidney.
Topics: Animals; Blood Proteins; Diuresis; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Kidney; Male; Probenecid; Pyrazinamide; Pyrazines; Swine; Uric Acid; Urine | 1976 |
Renal excretion of a slauretic-uricosuric agent (MK-196) and interaction with a urate-retaining drug, pyrazinoate, in the chimpanzee.
Topics: Acetazolamide; Animals; Diuresis; Drug Interactions; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Indans; Indenes; Kidney; Male; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Pyrazines; Sodium Chloride; Time Factors; Uric Acid; Uricosuric Agents | 1977 |
Urate excretion: drug interactions.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Glomerular Filtration Rate; Haplorhini; Male; Models, Biological; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Salicylates; Ultrafiltration; Uric Acid; Uricosuric Agents | 1979 |
The natural history of urate overproduction in sickle cell anemia.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Creatinine; Female; Humans; Male; Middle Aged; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1979 |
Hypouricemia by defect in the tubular reabsorption.
Topics: Absorption; Adult; Female; Humans; Kidney Function Tests; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1979 |
Familial renal hypouricaemia: two additional cases with uric acid lithiasis.
Topics: Adult; Calcium; Humans; Jews; Kidney Calculi; Kidney Diseases; Male; Pedigree; Probenecid; Pyrazinamide; Recurrence; Uric Acid; Urinary Calculi | 1979 |
Inborn hypouricemia due to isolated renal tubular defect.
Topics: Adult; Calcium; Chromosome Aberrations; Chromosome Disorders; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1979 |
Handling of oxalate by the rat kidney.
Topics: Animals; Biological Transport; Inulin; Kidney; Kidney Tubules, Proximal; Male; Oxalates; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats | 1978 |
Familial hypouricemia due to isolated renal tubular abnormality.
Topics: Chromosome Aberrations; Chromosome Disorders; Genes, Recessive; Humans; Male; Middle Aged; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1978 |
Hereditary renal hypouricemia: heterogeneity of tubular abnormality.
Topics: Adult; Calcium; Female; Humans; Male; Middle Aged; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Uric Acid | 1978 |
Species variations among primates in responses to drugs which alter the renal excretion of uric acid.
Topics: Animals; Female; Haplorhini; Humans; Kidney; Male; Pan troglodytes; Probenecid; Protein Binding; Pyrazinamide; Salicylates; Species Specificity; Uric Acid; Uricosuric Agents | 1975 |
Inhibition of probenecid uricosuria by pyrazinamide and para-aminohippurate.
Topics: Adolescent; Adult; Aminohippuric Acids; Depression, Chemical; Humans; Male; Middle Aged; p-Aminohippuric Acid; Probenecid; Pyrazinamide; RNA; Uric Acid | 1977 |
Familial hypouricemia due to isolated renal tubular defect. Attenuated response of uric acid clearance to probenecid and pyrazinamide.
Topics: Adult; Female; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules, Proximal; Probenecid; Pyrazinamide; Uric Acid | 1977 |
Renal tubular transport of urate in Fanconi syndrome.
Topics: Amino Acids; Biological Transport; Fanconi Syndrome; Female; Glomerular Filtration Rate; Glycosuria; Humans; Kidney Tubules; Middle Aged; Phosphates; Probenecid; Pyrazinamide; Uric Acid | 1977 |
Evidence for two secretory mechanisms for organic acid transport in man.
Topics: Biological Transport; Humans; Kidney Tubules; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1977 |
Familial renal hypouricemia due to isolated tubular defect.
Topics: Adult; Female; Humans; Kidney Function Tests; Pedigree; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1977 |
Renal urate excretion in five cases of hypouricemia with an isolated renal defect of urate transport.
Topics: Adult; Humans; Male; Middle Aged; Pedigree; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1977 |
Effect of pharmacological inhibitors on urate transport during induced uricosuria.
Topics: Adult; Biological Transport; Humans; Kidney; Middle Aged; Probenecid; Pyrazinamide; RNA; Sodium Chloride; Uric Acid | 1977 |
The effect of the interaction of pyrazinamide and probenecid on urinary uric acid excretion in man.
Topics: Adult; Aged; Drug Interactions; Half-Life; Humans; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1977 |
A case of uric acid renal stone with hypouricemia caused by tubular reabsorptive defect of uric acid.
Topics: Creatinine; Glycine; Humans; Kidney Calculi; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1976 |
Hyperuricosuria and increased tubular secretion of urate in sickle cell anemia.
Topics: Adolescent; Adult; Aminohippuric Acids; Anemia, Sickle Cell; Biological Transport; Female; Glomerular Filtration Rate; Humans; Kidney Tubules; Male; Probenecid; Pyrazinamide; RNA; Saccharomyces cerevisiae; Uric Acid | 1975 |
Urate excretion by the cat kidney.
Topics: Animals; Cats; Female; Kidney; Male; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1992 |
Renal handling of urate in two patients with hyperuricemia and primary hyperparathyroidism.
Topics: Aged; Female; Humans; Hyperparathyroidism; Kidney; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1992 |
Decreased renal clearance of xanthine and hypoxanthine in a patient with renal hypouricemia: a new defect in renal handling of purines.
Topics: Humans; Hypoxanthine; Hypoxanthines; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Parkinson Disease; Probenecid; Pyrazinamide; Uric Acid; Xanthine; Xanthines | 1992 |
Single kidney function: early and late changes in urate transport after nephrectomy.
Topics: Adult; Aged; Biological Transport, Active; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Tubules; Male; Middle Aged; Nephrectomy; Probenecid; Pyrazinamide; Renal Circulation; Time Factors; Uric Acid | 1992 |
Two cases of persistent hypouricemia associated with diabetes mellitus.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1992 |
Cholangiocarcinoma and severe renal hypouricemia: a study of the renal mechanisms.
Topics: Adenoma, Bile Duct; Bile Duct Neoplasms; Humans; Kidney; Kidney Function Tests; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1991 |
Urate transport in the proximal tubule of human kidney.
Topics: Biological Transport; Humans; Kidney Cortex; Kidney Tubules, Proximal; Kinetics; Lactates; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1991 |
Renal hypouricemia associated with hyperoxypurinemia due to decreased renal excretion of oxypurines: a new defect in renal purine transport.
Topics: Diet; Humans; Hypoxanthine; Hypoxanthines; Kidney Diseases; Kidney Tubules; Kinetics; Male; Middle Aged; Probenecid; Purines; Pyrazinamide; Uric Acid; Xanthine; Xanthines | 1991 |
Hyperuricemia induced by the uricosuric drug probenecid in rats.
Topics: Allopurinol; Animals; Hepatectomy; Hypoxanthines; Inulin; Kidney Function Tests; Male; Oxonic Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Uric Acid; Xanthines | 1991 |
Insulin-dependent diabetes and renal hypouricemia.
Topics: Adolescent; Adult; Creatinine; Diabetes Mellitus, Type 1; Female; Humans; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1991 |
The influence of co-administered organic acids on the kinetics and dynamics of frusemide.
Topics: Adult; Drug Interactions; Furosemide; Humans; Male; Probenecid; Pyrazinamide | 1991 |
Renal tubular hypouricemia: evidence for defect of both secretion and reabsorption.
Topics: Aged; Aspirin; Creatinine; Furosemide; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1990 |
Evaluation of urate renal handling in humans.
Topics: Adult; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Male; Probenecid; Pyrazinamide; Uric Acid | 1989 |
Urate excretion by the isolated perfused rat kidney and modification by drugs.
Topics: Animals; Furosemide; Glomerular Filtration Rate; Kidney; Natriuresis; Oxonic Acid; Perfusion; Probenecid; Pyrazinamide; Rats; Salicylates; Salicylic Acid; Uric Acid | 1989 |
Renal excretions of oxypurinol and oxypurines--effects of pyrazinamide, probenecid and benzbromarone.
Topics: Adult; Benzbromarone; Gout Suppressants; Humans; Kidney; Male; Metabolic Clearance Rate; Oxypurinol; Probenecid; Pyrazinamide; Pyrimidines | 1989 |
Renal excretion of purine bases--effects of probenecid, benzbromarone and pyrazinamide.
Topics: Adult; Benzbromarone; Gout Suppressants; Humans; Kidney; Male; Metabolic Clearance Rate; Probenecid; Purines; Pyrazinamide | 1989 |
Stop-flow studies on tubular transport of uric acid in rats.
Topics: Animals; Kidney; Male; Metabolic Clearance Rate; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Stereoisomerism; Sulfonamides; Ticrynafen; Uric Acid | 1989 |
[Effect of exercise on urate excretion].
Topics: Adult; Benzbromarone; Depression, Chemical; Exercise; Glomerular Filtration Rate; Humans; Kidney; Male; Probenecid; Pyrazinamide; Uric Acid | 1989 |
Hypouricemia due to familial isolated renal tubular uricosuria. Evaluation with the combined pyrazinamide-probenecid test.
Topics: Creatinine; Female; Humans; Kidney; Middle Aged; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1989 |
Pharmacological evaluation of urate renal handling in humans: pyrazinamide test vs combined pyrazinamide and probenecid administration.
Topics: Adult; Aged; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Premedication; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Renal excretion of purine bases. Effects of probenecid, benzbromarone and pyrazinamide.
Topics: Adult; Benzbromarone; Benzofurans; Biological Transport, Active; Female; Humans; Hypoxanthine; Hypoxanthines; Kidney; Male; Probenecid; Purines; Pyrazinamide; Uric Acid; Xanthine; Xanthines | 1988 |
Hypouricemia due to increased tubular urate secretion.
Topics: Humans; Kidney Tubules; Probenecid; Pyrazinamide; Uric Acid | 1988 |
The renal handling of urate in acute renal failure patients with high urine uric acid/urine creatinine concentration ratio.
Topics: Acute Kidney Injury; Adult; Creatine; Female; Humans; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1988 |
Hypouricemia due to subtotal defect in the urate transport.
Topics: Adult; Biological Transport; Female; Humans; Kidney Diseases; Kidney Tubules; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Drug interactions with urate excretion in man.
Topics: Adult; Ampicillin; Benzbromarone; Benzofurans; Drug Interactions; Humans; Kidney; Kinetics; Male; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Evaluation of the renal mechanisms for urate homeostasis in uremic patients by probenecid and pyrazinamide test.
Topics: Absorption; Creatinine; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Kidney Failure, Chronic; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uremia; Uric Acid | 1987 |
Competition of organic anions for furosemide and p-aminohippurate secretion in the rabbit.
Topics: Aminohippuric Acids; Animals; Biological Transport; Female; Furosemide; Glomerular Filtration Rate; In Vitro Techniques; Indomethacin; Kidney; Male; Natriuresis; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rabbits; Time Factors; Tritium | 1986 |
Possible active tubular secretion of sulfamonomethoxine and its metabolites in pigs.
Topics: Acetylation; Animals; Diuresis; Kidney Tubules; Kinetics; Male; Probenecid; Pyrazinamide; Sulfamonomethoxine; Sulfanilamides; Swine; Swine, Miniature | 1986 |
Renal handling of uric acid in gout: impaired tubular transport of urate not dependent on serum urate levels.
Topics: Adult; Aged; Biological Transport, Active; Gout; Humans; Kidney Tubules; Kinetics; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1986 |
Hypouricemia due to increased tubular urate secretion.
Topics: Creatinine; Female; Humans; Kidney Tubules; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Familial renal hypouricemia with intact reabsorption of uric acid.
Topics: Adult; Female; Humans; Kidney Diseases; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Diabetic renal hypouricemia.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1987 |
[Hypouricemia caused by an isolated tubular defect. Apropos of a case].
Topics: Humans; Male; Middle Aged; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1985 |
Hypouricemia due to renal tubular defect. A study with the probenecid-pyrazinamide test.
Topics: Adult; Calcium; Creatinine; Female; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1985 |
Nature of the uricosuric action of benziodarone.
Topics: Adult; Aminohippuric Acids; Animals; Benzofurans; Carbon Isotopes; Creatinine; Female; Glomerular Filtration Rate; Haplorhini; Humans; Inulin; Iodobenzoates; Kidney Tubules; Kidney Tubules, Proximal; Male; Probenecid; Pyrazinamide; Tritium; Uric Acid; Uricosuric Agents | 1973 |
Bidirectional renal urate transport in the chimpanzee. Effects of drugs on secretory and reabsorptive fluxes.
Topics: Aminohippuric Acids; Animals; Biological Transport; Glomerular Filtration Rate; Kidney Tubules; Kidney Tubules, Distal; Male; Mersalyl; Pan troglodytes; Probenecid; Pyrazinamide; Pyrazines; Salicylates; Uric Acid; Uricosuric Agents | 1974 |
Hypouricemia, hypercalciuria, and decreased bone density: a hereditary syndrome.
Topics: Aged; Bone Density; Bone Diseases; Calcium; Calcium Gluconate; Child; Child, Preschool; Consanguinity; Female; Humans; Male; Middle Aged; Pedigree; Probenecid; Pyrazinamide; Syndrome; Uric Acid | 1974 |
Origins of the uricosuric response.
Topics: Adult; Aminohippuric Acids; Chlorothiazide; Female; Glomerular Filtration Rate; Humans; Inulin; Kidney; Male; Middle Aged; Natriuresis; Phosphates; Phosphorus; Probenecid; Pyrazinamide; Sodium; Uric Acid; Urination | 1973 |
Evidence for a postsecretory reabsorptive site for uric acid in man.
Topics: Absorption; Adult; Aspirin; Female; Humans; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Sulfinpyrazone; Uric Acid | 1973 |
Suppression of uric acid secretion in a patient with renal hypouricemia.
Topics: Circadian Rhythm; Creatinine; Female; Humans; Kidney Diseases; Middle Aged; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Salicylates; Time Factors; Uric Acid | 1974 |
Reevaluation of the pyrazinamide suppression test.
Topics: Evaluation Studies as Topic; Glomerular Filtration Rate; Male; Methods; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Uric Acid | 1974 |
Evidence for a post-secretory reabsorptive site for uric acid in man.
Topics: Aspirin; Biological Transport; Fasting; Humans; Kidney Tubules; Probenecid; Pyrazinamide; Sulfinpyrazone; Time Factors; Uric Acid | 1974 |
[Effect of benziodarone on the renal excretion of uric acid].
Topics: Gout; Humans; Probenecid; Pyrazinamide; Uricosuric Agents | 1967 |
Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aminohippuric Acids; Animals; Biological Transport; Carbon Radioisotopes; Cell Membrane; Furosemide; Hydrogen-Ion Concentration; Kidney Cortex; Kinetics; Microvilli; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Tritium; Uric Acid | 1983 |
Decreased renal excretion of uric acid following diuretic administration in rats.
Topics: Animals; Diuretics; Furosemide; Insulin; Male; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Trichlormethiazide; Uric Acid | 1984 |
A microelectrode for continuous monitoring of redox activity in isolated perfused tubule segments.
Topics: Animals; In Vitro Techniques; Kidney Tubules; Kidney Tubules, Proximal; Mice; Mice, Inbred Strains; Microelectrodes; Monitoring, Physiologic; Oxidation-Reduction; Perfusion; Platinum; Probenecid; Pyrazinamide; Uric Acid | 1984 |
Renal handling of uric acid in normal subjects by means of the pyrazinamide and probenecid tests.
Topics: Adult; Glomerular Filtration Rate; Homeostasis; Humans; Kidney; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1983 |
Renal handling of uric acid in gout by means of the pyrazinamide and probenecid tests.
Topics: Adult; Gout; Humans; Kidney; Kidney Tubules; Probenecid; Pyrazinamide; Reference Values; Uric Acid | 1984 |
[A case of familial renal hypouricemia associated with bladder cancer].
Topics: Aged; Benzbromarone; Carcinoma, Transitional Cell; Humans; Male; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid; Urinary Bladder Neoplasms | 1984 |
Hypouricemia due to an isolated defect in renal tubular urate reabsorption.
Topics: Adult; beta 2-Microglobulin; Chronic Disease; Glomerulonephritis; Humans; Kidney; Male; Phosphates; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1980 |
[Renal physiopathology of uric acid. Pharmacologic study].
Topics: Humans; Kidney Diseases; Kidney Tubules; Probenecid; Pyrazinamide; Uric Acid; Uricosuric Agents | 1982 |
A case of familial renal hypouricemia associated with increased secretion of para-aminohippurate and idiopathic edema.
Topics: Adult; Aged; Aminohippuric Acids; Edema; Female; Humans; Kidney Function Tests; Male; p-Aminohippuric Acid; Pedigree; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Saline Solution, Hypertonic; Ticrynafen; Uric Acid | 1982 |
Hypouricemia due to an increment in renal tubular urate secretion.
Topics: Adult; Female; Humans; Kidney Tubules; Metabolic Clearance Rate; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1982 |
[Paraneoplastic hypouricemia in Hodgkin's lymphoma secondary to a renal tubular reabsorption defect of uric acid (author's transl)].
Topics: Adult; Hodgkin Disease; Humans; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1981 |
Renal pathogenesis of familial hyperuricemia: studies in two kindreds.
Topics: Adolescent; Ascorbic Acid; Humans; Kidney; Kidney Tubules; Male; Probenecid; Protein Binding; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Uric Acid | 1981 |
Uptake of [3H]PAH and [14C]urate into isolated proximal tubular segments of the pig kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Female; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Swine; Uric Acid | 1981 |
Urate metabolism in a mongrel dog.
Topics: Allantoin; Animals; Carbon Radioisotopes; Dogs; Probenecid; Pyrazinamide; Salicylates; Uric Acid | 1980 |
Accumulation of [14C]urate and [3H]PAH in isolated proximal tubular segments of the rabbit kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport; Carbon Radioisotopes; Female; In Vitro Techniques; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Pyrazinamide; Rabbits; Tritium; Uric Acid | 1980 |
Impairment of tubular secretion of urate in renal transplant patients on cyclosporine.
Topics: Adult; Benzofurans; Cyclosporine; Female; Humans; Kidney Transplantation; Kidney Tubules; Male; Middle Aged; Prevalence; Probenecid; Pyrazinamide; Retrospective Studies; Uric Acid; Uricosuric Agents | 1995 |
Pharmacologic evaluation of the renal handling of uric acid and oxypurines.
Topics: Adult; Benzbromarone; Biological Transport; Humans; Hypoxanthine; Hypoxanthines; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid; Xanthines | 1994 |
Renal hypouricemia: incomplete combined defect.
Topics: Adult; Benzbromarone; Calcium; Humans; Male; Nephrosis, Lipoid; Probenecid; Pyrazinamide; Uric Acid | 1994 |
Hypouricemia due to increased tubular secretion of urate in children with Amanita phalloides poisoning.
Topics: Adolescent; Amanita; Biological Transport, Active; Child; Child, Preschool; Female; Humans; Kidney Tubules; Male; Mushroom Poisoning; Probenecid; Pyrazinamide; Uric Acid | 1993 |
Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.
Topics: Benzbromarone; Citrates; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Kidney Tubules; Middle Aged; Probenecid; Pyrazinamide; Uric Acid; Urinary Calculi | 1993 |
Evidence of defective tubular reabsorption and normal secretion of uric acid in the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Absorption; Aged; Female; Humans; Inappropriate ADH Syndrome; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1993 |
Renal handling of urate in a patient with familial juvenile gouty nephropathy.
Topics: Adolescent; Benzbromarone; Female; Genes, Dominant; Gout; Gout Suppressants; Humans; Kidney; Kidney Failure, Chronic; Male; Pedigree; Probenecid; Pyrazinamide; Renal Agents; Uric Acid; Uricosuric Agents | 1996 |
Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles.
Topics: Aged; Benzbromarone; Biological Transport; Biphenyl Compounds; Carbon Radioisotopes; Diuretics; Ethambutol; Humans; Imidazoles; Kidney Cortex; Kidney Neoplasms; Kinetics; Losartan; Microvilli; Middle Aged; Probenecid; Pyrazinamide; Salicylates; Salicylic Acid; Sulfinpyrazone; Tetrazoles; Ticrynafen; Uric Acid; Uricosuric Agents | 1997 |
Hematuria in patients with renal hypouricemia.
Topics: Adult; Aged; Aged, 80 and over; Benzbromarone; Creatinine; Female; Hematuria; Humans; Kidney Diseases; Male; Metabolism, Inborn Errors; Middle Aged; Probenecid; Pyrazinamide; Renal Agents; Uric Acid | 1998 |
Restoration of the uricosuric effect of probenecid after triglycylvasopressine administration in a gouty patient.
Topics: Absorption; Acute Kidney Injury; Adult; Anti-Inflammatory Agents; Benzbromarone; Fludrocortisone; Gout; Humans; Kidney Tubules; Lypressin; Male; Probenecid; Pyrazinamide; Receptors, Vasopressin; Renal Agents; Terlipressin; Uric Acid; Uricosuric Agents | 1998 |
Exercise-induced acute renal failure in a patient with renal hypouricemia.
Topics: Acute Kidney Injury; Child; Creatinine; Exercise; Follow-Up Studies; Humans; Kidney; Kidney Tubules; Male; Necrosis; Probenecid; Pyrazinamide; Reference Values; Uric Acid | 2000 |
Urate transport via human PAH transporter hOAT1 and its gene structure.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Biological Transport; Blotting, Western; Carbon Radioisotopes; Cell Line; Cloning, Molecular; Exons; Female; Gene Library; Gout; Humans; Kidney; Kidney Diseases; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Protein Structure, Tertiary; Pyrazinamide; Sodium Salicylate; Uric Acid; Uricosuric Agents | 2003 |
The effect of probenecid on pyrazinamide blood levels and pyrazinamide-induced hyperuricemia.
Topics: Humans; Hyperuricemia; Niacin; Nicotinic Acids; Probenecid; Pyrazinamide; Uric Acid | 1957 |
ASSOCIATION OF HYPERURICAEMIA AND GOUT WITH HYPERPARATHYROIDISM.
Topics: Adenoma; Blood Chemical Analysis; Diagnosis; Gout; Humans; Hyperparathyroidism; Hyperuricemia; Nephrocalcinosis; Parathyroid Neoplasms; Prednisone; Probenecid; Pyrazinamide; Surgical Procedures, Operative; Uric Acid | 1964 |
Effects of probenecid, sodium salicylate, 2,4-dinitrophenol and pyrazinamide on renal secretion of uric acid in chickens.
Topics: 2,4-Dinitrophenol; Animals; Chickens; Dinitrophenols; Kidney; Nitrophenols; Probenecid; Pyrazinamide; Sodium Chloride; Sodium Salicylate; Uric Acid | 1959 |
Two male siblings with hereditary renal hypouricemia and exercise-induced ARF.
Topics: Acute Kidney Injury; Adult; Back Pain; Carrier Proteins; Codon, Nonsense; Creatinine; Exercise; Exons; Humans; Kidney Function Tests; Male; Metabolism, Inborn Errors; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Pedigree; Probenecid; Pyrazinamide; Running; Uric Acid; Urinary Calculi | 2003 |
Phenolsulfonphthalein transport by potential-sensitive urate transport system.
Topics: Animals; Biological Transport; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane; Chlorides; Dose-Response Relationship, Drug; Ionophores; Kidney; Male; Mannitol; Membrane Potentials; Microvilli; Phenolsulfonphthalein; Potassium Chloride; Probenecid; Pyrazinamide; Rats; Rats, Wistar; Time Factors; Uric Acid; Valinomycin | 2005 |