pyrazinamide and benzbromarone

pyrazinamide has been researched along with benzbromarone in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (32.61)	18.7374
1990's	16 (34.78)	18.2507
2000's	4 (8.70)	29.6817
2010's	11 (23.91)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Avery, GS; Brogden, RN; Heel, RC; Speight, TM	1
Fox, IH; Sinclair, DS	2
Agbedana, EO; Higashino, K; Moriwaki, Y; Suda, M; Takahashi, S; Yamamoto, T	1
Agbedana, OE; Hada, T; Higashino, K; Moriwaki, Y; Suda, M; Takahashi, S; Yamamoto, T	1
Tykarski, A	1
Higashino, K; Moriwaki, Y; Suda, M; Takahashi, S; Yamamoto, T	1
Hada, T; Higashino, K; Moriwaki, Y; Takahashi, S; Yamamoto, T	4
Goto, H; Ito, A; Mikami, T	1
Hasegawa, J; Hisatome, I; Ishiko, R; Kotake, H; Mashiba, H; Nakamoto, S; Ogino, K; Saito, M	1
Hasegawa, J; Hisatome, I; Kotake, H; Mashiba, H; Miyamoto, J; Nakamoto, S; Ogino, K; Saito, M	1
Schoeman, HS; Sommers, DK	1
Hwang, TJ; Ito, M; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Toshima, K; Watanabe, T; Yokota, I	1
Homma, Y; Kitamura, T; Nishimura, Y	1
Kuroda, M; Takeda, R; Tofuku, Y	1
Levinson, DJ; Sorensen, LB	2
Hiroshige, K; Kuroiwa, A; Takasugi, M; Yuu, K	1
Kawai, S; Osawa, G; Yamada, M	1
Posadzy-Małaczyńska, A; Pupek-Musialik, D; Tykarski, A	1
Fujimoto, Y; Hirata, N; Hisatome, I; Kosaka, H; Kotake, H; Mashiba, H; Sato, R; Shigemasa, C; Tanaka, Y; Yoshida, A	1
Hiroshige, K; Kuroiwa, A; Soejima, M; Takasugi, M; Yuu, K	1
Fujimoto, Y; Hisatome, I; Igawa, O; Kosaka, H; Manabe, I; Ohtahara, A; Ohtahara, K; Sawaguchi, M; Shigemasa, C; Takeda, A; Tanaka, Y; Tsuboi, M; Yoshida, A	1
Higashino, K; Hiroishi, K; Moriwaki, Y; Naito, Y; Nasako, Y; Takahashi, S; Yamakita, J; Yamamoto, T	1
Diezi, J; Guisan, B; Roch-Ramel, F	1
Fujita, K; Hirasaki, S; Koide, N; Ogawa, H; Tsuji, T	1
Hamada, N; Hiroe, K; Hisatome, I; Kato, T; Kinugawa, T; Manabe, I; Ogino, K; Ohtahara, A; Sato, R; Shigemasa, C; Shimoyama, M; Takeda, A; Tanaka, Y; Tsuboi, M; Yamamoto, Y; Yoshida, A	1
Decaux, G; Hannotier, P; Musch, W; Prospert, F; Soupart, A	1
Furuyama, T; Ikarashi, T; Ito, S; Kurihara, I; Miura, R; Saito, T; Sato, H; Sato, M; Soma, J; Suzuki, T; Tsunoda, K	1
Endou, H; Hosoya, T; Hosoyamada, M; Ichida, K; Kimura, H; Takeda, M; Utsunomiya, Y	1
Hosoyamada, M; Ichida, K	1
Hasegawa, Y; Ito, O; Ito, S; Kudo, K; Mitsui, H; Sato, H; Sato, K; Yuda, F	1
Mamada, H; Nakanishi, T; Sato, M; Shirasaka, Y; Tamai, I; Wakayama, T	1
Anzai, N; Nakanishi, T; Ohya, K; Shimada, S; Tamai, I	1

Reviews

3 review(s) available for pyrazinamide and benzbromarone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia. Drugs, 1977, Volume: 14, Issue:5 Topics: Aspirin; Benzbromarone; Benzofurans; Drug Interactions; Fasting; Gout; Humans; Kidney Diseases; Kinetics; Lipid Metabolism; Pyrazinamide; Triglycerides; Uric Acid; Xanthine Oxidase	1977
[Molecular mechanism for urinary excretion of hypoxanthine and xanthine]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1 Topics: Animals; Benzbromarone; Biological Transport; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Kidney; Membrane Transport Proteins; Probenecid; Pyrazinamide; Uricosuric Agents; Xanthine	2003

Trials

1 trial(s) available for pyrazinamide and benzbromarone

Article	Year
Effects of pyrazinamide, probenecid, and benzbromarone on renal excretion of oxypurinol. Annals of the rheumatic diseases, 1991, Volume: 50, Issue:9 Topics: Adult; Benzbromarone; Biological Transport; Humans; Kidney; Male; Oxypurinol; Probenecid; Pyrazinamide	1991

Other Studies

42 other study(ies) available for pyrazinamide and benzbromarone

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
The pharmacology of the hypouricemic effect of benzbromarone. Advances in experimental medicine and biology, 1977, Volume: 76B Topics: Aspirin; Benzbromarone; Benzofurans; Blood Proteins; Drug Interactions; Glomerular Filtration Rate; Kidney Tubules; Protein Binding; Pyrazinamide; Sulfinpyrazone; Uric Acid; Xanthine Oxidase	1977
The pharmacology of hypouricemic effect of benzbromarone. The Journal of rheumatology, 1975, Volume: 2, Issue:4 Topics: Adult; Aspirin; Benzbromarone; Benzofurans; Blood Proteins; Creatinine; Female; Gout; Humans; Male; Middle Aged; Protein Binding; Pyrazinamide; Sulfinpyrazone; Uric Acid; Uricosuric Agents	1975
Two cases in whom pyrazinamide does not inhibit the uricosuric action of benzbromarone. Nephron, 1992, Volume: 61, Issue:4 Topics: Adult; Benzbromarone; Diabetes Mellitus, Type 2; Drug Interactions; Female; Humans; Kidney; Kidney Diseases; Male; Pyrazinamide; Uric Acid	1992
Analysis of uric acid transport in renal tubules using benzbromarone and pyrazinamide. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Absorption; Adult; Benzbromarone; Humans; Kidney Tubules; Male; Middle Aged; Models, Biological; Pyrazinamide; Uric Acid	1991
[Uric acid and arterial hypertension. II. Evaluation of uric acid transport in the nephrons in primary arterial hypertension]. Polskie Archiwum Medycyny Wewnetrznej, 1991, Volume: 86, Issue:3 Topics: Adult; Benzbromarone; Biological Transport; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Male; Middle Aged; Pyrazinamide; Uric Acid	1991
Analysis of uric acid transport in renal tubules using benzbromarone and pyrazinamide. International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:2 Topics: Benzbromarone; Benzofurans; Glomerular Filtration Rate; Humans; Kidney Tubules; Male; Pyrazinamide; Uric Acid	1990
Renal excretions of oxypurinol and oxypurines--effects of pyrazinamide, probenecid and benzbromarone. Advances in experimental medicine and biology, 1989, Volume: 253A Topics: Adult; Benzbromarone; Gout Suppressants; Humans; Kidney; Male; Metabolic Clearance Rate; Oxypurinol; Probenecid; Pyrazinamide; Pyrimidines	1989
Renal excretion of purine bases--effects of probenecid, benzbromarone and pyrazinamide. Advances in experimental medicine and biology, 1989, Volume: 253A Topics: Adult; Benzbromarone; Gout Suppressants; Humans; Kidney; Male; Metabolic Clearance Rate; Probenecid; Purines; Pyrazinamide	1989
[Effect of exercise on urate excretion]. Nihon seirigaku zasshi. Journal of the Physiological Society of Japan, 1989, Volume: 51, Issue:7 Topics: Adult; Benzbromarone; Depression, Chemical; Exercise; Glomerular Filtration Rate; Humans; Kidney; Male; Probenecid; Pyrazinamide; Uric Acid	1989
Cause of persistent hypouricemia in outpatients. Nephron, 1989, Volume: 51, Issue:1 Topics: Benzbromarone; Female; Hematuria; Humans; Male; Outpatients; Patients; Pyrazinamide; Uric Acid	1989
Renal excretion of purine bases. Effects of probenecid, benzbromarone and pyrazinamide. Nephron, 1988, Volume: 48, Issue:2 Topics: Adult; Benzbromarone; Benzofurans; Biological Transport, Active; Female; Humans; Hypoxanthine; Hypoxanthines; Kidney; Male; Probenecid; Purines; Pyrazinamide; Uric Acid; Xanthine; Xanthines	1988
Renal hypouricemia due to an isolated renal defect of urate transport. Nephron, 1988, Volume: 49, Issue:1 Topics: Adult; Benzbromarone; Humans; Kidney; Kidney Diseases; Male; Pyrazinamide; Uric Acid	1988
Drug interactions with urate excretion in man. European journal of clinical pharmacology, 1987, Volume: 32, Issue:5 Topics: Adult; Ampicillin; Benzbromarone; Benzofurans; Drug Interactions; Humans; Kidney; Kinetics; Male; Probenecid; Pyrazinamide; Uric Acid	1987
Hereditary renal hypouricemia in children. The Journal of pediatrics, 1985, Volume: 107, Issue:1 Topics: Benzbromarone; Child; Child, Preschool; Creatinine; Humans; Kidney Diseases; Kidney Tubules; Metabolic Clearance Rate; Pyrazinamide; Uric Acid	1985
[A case of familial renal hypouricemia associated with bladder cancer]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1984, Volume: 75, Issue:2 Topics: Aged; Benzbromarone; Carcinoma, Transitional Cell; Humans; Male; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid; Urinary Bladder Neoplasms	1984
Hypouricemia due to renal urate wasting. Two types of tubular transport defect. Nephron, 1982, Volume: 30, Issue:1 Topics: Adult; Benzbromarone; Biological Transport; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney Tubules, Proximal; Middle Aged; Pyrazinamide; Uric Acid	1982
Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system. Annals of the rheumatic diseases, 1980, Volume: 39, Issue:2 Topics: Absorption; Benzbromarone; Blood Proteins; Female; Gout; Humans; In Vitro Techniques; Kidney; Kidney Tubules; Male; Models, Biological; Protein Binding; Pyrazinamide; Secretory Rate; Temperature; Uric Acid	1980
Isolated defect in postsecretory reabsorption of uric acid. Annals of the rheumatic diseases, 1980, Volume: 39, Issue:2 Topics: Absorption; Adult; Benzbromarone; Female; Humans; Metabolic Diseases; Pyrazinamide; Uric Acid	1980
Pharmacologic evaluation of the renal handling of uric acid and oxypurines. Nihon Jinzo Gakkai shi, 1994, Volume: 36, Issue:11 Topics: Adult; Benzbromarone; Biological Transport; Humans; Hypoxanthine; Hypoxanthines; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid; Xanthines	1994
Renal hypouricemia: incomplete combined defect. Nihon Jinzo Gakkai shi, 1994, Volume: 36, Issue:8 Topics: Adult; Benzbromarone; Calcium; Humans; Male; Nephrosis, Lipoid; Probenecid; Pyrazinamide; Uric Acid	1994
[Evaluation of uric acid transport in nephrons of patients with calcium nephrolithiasis and hyperuricosuria]. Polskie Archiwum Medycyny Wewnetrznej, 1993, Volume: 90, Issue:1 Topics: Absorption; Adult; Benzbromarone; Calcium; Female; Humans; Kidney Calculi; Male; Middle Aged; Nephrons; Pyrazinamide; Recurrence; Uric Acid	1993
Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate. Nephron, 1993, Volume: 65, Issue:4 Topics: Benzbromarone; Citrates; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Kidney Tubules; Middle Aged; Probenecid; Pyrazinamide; Uric Acid; Urinary Calculi	1993
[A study on uric acid excretion in patients with hypouricemia]. Nihon Jinzo Gakkai shi, 1993, Volume: 35, Issue:7 Topics: Acute Kidney Injury; Benzbromarone; Diabetes Complications; Diabetes Mellitus; Female; Humans; Kidney; Kidney Function Tests; Male; Middle Aged; Pyrazinamide; Uric Acid	1993
Renal handling of urate in a patient with familial juvenile gouty nephropathy. Internal medicine (Tokyo, Japan), 1996, Volume: 35, Issue:7 Topics: Adolescent; Benzbromarone; Female; Genes, Dominant; Gout; Gout Suppressants; Humans; Kidney; Kidney Failure, Chronic; Male; Pedigree; Probenecid; Pyrazinamide; Renal Agents; Uric Acid; Uricosuric Agents	1996
Uric acid transport in fanconi syndrome with marked renal hypouricemia: analysis using pyrazinamide and benzbromarone. Nephron, 1996, Volume: 74, Issue:2 Topics: Adolescent; Benzbromarone; Fanconi Syndrome; Humans; Kidney; Male; Pyrazinamide; Time Factors; Uric Acid; Uricosuric Agents	1996
Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2 Topics: Aged; Benzbromarone; Biological Transport; Biphenyl Compounds; Carbon Radioisotopes; Diuretics; Ethambutol; Humans; Imidazoles; Kidney Cortex; Kidney Neoplasms; Kinetics; Losartan; Microvilli; Middle Aged; Probenecid; Pyrazinamide; Salicylates; Salicylic Acid; Sulfinpyrazone; Tetrazoles; Ticrynafen; Uric Acid; Uricosuric Agents	1997
Two cases of renal hypouricemia with nephrolithiasis. Internal medicine (Tokyo, Japan), 1997, Volume: 36, Issue:3 Topics: Adult; Benzbromarone; Creatinine; Humans; Kidney Calculi; Kidney Tubules; Male; Middle Aged; Pyrazinamide; Uric Acid; Uricosuric Agents	1997
Hematuria in patients with renal hypouricemia. Internal medicine (Tokyo, Japan), 1998, Volume: 37, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Benzbromarone; Creatinine; Female; Hematuria; Humans; Kidney Diseases; Male; Metabolism, Inborn Errors; Middle Aged; Probenecid; Pyrazinamide; Renal Agents; Uric Acid	1998
Restoration of the uricosuric effect of probenecid after triglycylvasopressine administration in a gouty patient. Clinical nephrology, 1998, Volume: 50, Issue:4 Topics: Absorption; Acute Kidney Injury; Adult; Anti-Inflammatory Agents; Benzbromarone; Fludrocortisone; Gout; Humans; Kidney Tubules; Lypressin; Male; Probenecid; Pyrazinamide; Receptors, Vasopressin; Renal Agents; Terlipressin; Uric Acid; Uricosuric Agents	1998
A case of exercise-induced acute renal failure in a patient with enhanced renal hypouricaemia. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:1 Topics: Acute Kidney Injury; Adult; Benzbromarone; Exercise; Humans; Male; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid; Uricosuric Agents	2000
Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney international, 2003, Volume: 63, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Biological Transport; Blotting, Western; Carbon Radioisotopes; Cell Line; Cloning, Molecular; Exons; Female; Gene Library; Gout; Humans; Kidney; Kidney Diseases; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Protein Structure, Tertiary; Pyrazinamide; Sodium Salicylate; Uric Acid; Uricosuric Agents	2003
A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide. Hypertension research : official journal of the Japanese Society of Hypertension, 2003, Volume: 26, Issue:6 Topics: Acute Kidney Injury; Antihypertensive Agents; Benzbromarone; Blood Cell Count; Creatinine; Diuretics; Drug Therapy, Combination; Exercise; Humans; Hypertension; Kidney; Kidney Function Tests; Losartan; Male; Martial Arts; Middle Aged; Pyrazinamide; Sodium Chloride Symporter Inhibitors; Trichlormethiazide; Uric Acid	2003
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. Biochimica et biophysica acta, 2011, Volume: 1808, Issue:6 Topics: Animals; Anion Transport Proteins; Benzbromarone; Biological Transport; Epithelial Cells; Female; Humans; Immunohistochemistry; Kidney; Kinetics; Lactates; Male; Microvilli; Oocytes; Pyrazinamide; Rats; Rats, Sprague-Dawley; Rats, Wistar; Uric Acid; Xenopus laevis	2011
Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013, Volume: 28, Issue:3 Topics: Animals; Benzbromarone; Cells, Cultured; Dogs; Fluorescent Antibody Technique; Glucose Transport Proteins, Facilitative; Humans; Kidney; Lactic Acid; Madin Darby Canine Kidney Cells; Niacin; Oocytes; Organic Anion Transporters; Organic Cation Transport Proteins; Pyrazinamide; Uric Acid; Uricosuric Agents; Vasodilator Agents; Xenopus laevis	2013