pyrazinamide and allopurinol

pyrazinamide has been researched along with allopurinol in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (47.50)	18.7374
1990's	6 (15.00)	18.2507
2000's	3 (7.50)	29.6817
2010's	12 (30.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Boss, GR; Seegmiller, JE	1
Mir, MA	1
Avery, GS; Brogden, RN; Heel, RC; Speight, TM	1
Allan, WG; Fox, W; Girling, DJ; Horsfall, PA; Nunn, AJ; Plummer, J	1
Auscher, C; Delbarre, F; Pasquier, C; Pehuet, P	1
Fox, IH; Sinclair, DS	1
Shinosaki, T; Yonetani, Y	1
Amodio, MI; Bengualid, V; Lowy, FD	1
Hada, T; Higashino, K; Kawachi, M; Kono, N; Naka, M; Nanahoshi, M; Suda, M; Takahashi, S; Yamamoto, T	1
Hada, T; Higashino, K; Kawachi, M; Kono, N; Nanahoshi, M; Suda, M; Takahashi, S; Yamamoto, T	1
Chaou, M; Duwoos, H; Guyonnaud, C; Lacroix, C; Lafont, O	1
Hada, T; Higashino, K; Moriwaki, Y; Takahashi, S; Yamamoto, T	3
Tinker, JP; Weiner, IM	1
Bartel, AG; Kelley, WN; Postlethwaite, AE	1
Berger, L; Gutman, AB; Yü, TF	1
Rieselbach, RE; Shelp, WD; Sorensen, LB; Steele, TH	1
Berlyne, GM; Danovitch, GM; Weinberger, J	1
Rieselbach, RE; Steele, TH	1
Carini, M; Carlo, A; Facino, RM; Pitrè, D	1
Chouaid, C; Devin, E; Housset, C; Lebeau, B; Maquarre, E; Urban, T	1
Hada, T; Higashino, K; Moriwaki, Y; Nasako, Y; Takahashi, S; Tsutsumi, Z; Yamamoto, T	1
Hada, T; Higashino, K; Hiroishi, K; Moriwaki, Y; Nasako, Y; Suda, M; Takahashi, S; Yamamoto, T	1
Hada, T; Higashino, K; Hiroishi, K; Moriwaki, Y; Nakano, T; Nasako, Y; Suda, M; Takahashi, S; Yamamoto, T	1
Chan, KL; Murugaiyah, V	1
Aarnoutse, RE; Boeree, MJ; Peters, WH; Richard, PN; Tostmann, A	1
Akkoc, N; Bulac Kir, S; Gerdan, V; Ucan, ES	1
Aslan, AT; Budakoğlu, I; Şişmanlar, T	1

Reviews

3 review(s) available for pyrazinamide and allopurinol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Hyperuricemia and gout. Classification, complications and management. The New England journal of medicine, 1979, Jun-28, Volume: 300, Issue:26 Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Indomethacin; Kidney; Kidney Calculi; Kidney Diseases; Lead Poisoning; Lymphoproliferative Disorders; Myeloproliferative Disorders; Phenylbutazone; Platelet Aggregation; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Uricosuric Agents	1979
Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia. Drugs, 1977, Volume: 14, Issue:5 Topics: Aspirin; Benzbromarone; Benzofurans; Drug Interactions; Fasting; Gout; Humans; Kidney Diseases; Kinetics; Lipid Metabolism; Pyrazinamide; Triglycerides; Uric Acid; Xanthine Oxidase	1977

Trials

2 trial(s) available for pyrazinamide and allopurinol

Article	Year
Double blind controlled comparison of aspirin, allopurinol and placebo in the management of arthralgia during pyrazinamide administration. Tubercle, 1979, Volume: 60, Issue:1 Topics: Adolescent; Adult; Aged; Allopurinol; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Joint Diseases; Male; Middle Aged; Pain; Pyrazinamide; Random Allocation; Time Factors; Tuberculosis, Pulmonary; Uric Acid	1979
Renal function in gout. 3. Estimation of tubular secretion and reabsorption of uric acid by use of pyrazinamide (pyrazinoic acid). The American journal of medicine, 1969, Volume: 47, Issue:4 Topics: Adult; Allopurinol; Clinical Trials as Topic; Gout; Humans; Kidney Tubules; Metabolic Clearance Rate; Middle Aged; Pyrazinamide; RNA; Uric Acid	1969

Article

Year

Double blind controlled comparison of aspirin, allopurinol and placebo in the management of arthralgia during pyrazinamide administration.

Tubercle, 1979, Volume: 60, Issue:1

Topics: Adolescent; Adult; Aged; Allopurinol; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Joint Diseases; Male; Middle Aged; Pain; Pyrazinamide; Random Allocation; Time Factors; Tuberculosis, Pulmonary; Uric Acid

1979

Renal function in gout. 3. Estimation of tubular secretion and reabsorption of uric acid by use of pyrazinamide (pyrazinoic acid).

The American journal of medicine, 1969, Volume: 47, Issue:4

Topics: Adult; Allopurinol; Clinical Trials as Topic; Gout; Humans; Kidney Tubules; Metabolic Clearance Rate; Middle Aged; Pyrazinamide; RNA; Uric Acid

1969

Other Studies

35 other study(ies) available for pyrazinamide and allopurinol

Article	Year
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Renal excretion of uric acid and its relation to relapse and remission in acute myeloid leukaemia. Nephron, 1977, Volume: 19, Issue:2 Topics: Adolescent; Adult; Aged; Allopurinol; Creatinine; Female; Homeostasis; Humans; Kidney; Kidney Tubules; Leukemia, Myeloid, Acute; Male; Middle Aged; Pyrazinamide; Recurrence; Remission, Spontaneous; Uric Acid	1977
Study of urinary pyrazinamide metabolites and their action on the renal excretion of xanthine and hypoxanthine in a xanthinuric patient. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1978, Volume: 28, Issue:2 Topics: Chromatography, Ion Exchange; Depression, Chemical; Humans; Hypoxanthines; Kidney; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Xanthine Oxidase; Xanthines	1978
The pharmacology of the hypouricemic effect of benzbromarone. Advances in experimental medicine and biology, 1977, Volume: 76B Topics: Aspirin; Benzbromarone; Benzofurans; Blood Proteins; Drug Interactions; Glomerular Filtration Rate; Kidney Tubules; Protein Binding; Pyrazinamide; Sulfinpyrazone; Uric Acid; Xanthine Oxidase	1977
Hyperuricemia induced by the uricosuric drug probenecid in rats. Japanese journal of pharmacology, 1991, Volume: 55, Issue:4 Topics: Allopurinol; Animals; Hepatectomy; Hypoxanthines; Inulin; Kidney Function Tests; Male; Oxonic Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Uric Acid; Xanthines	1991
Development of acute gout secondary to pyrazinamide in a patient without a prior history of gout. DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:11 Topics: Aged; Allopurinol; Colchicine; Gout; Humans; Male; Pyrazinamide	1990
Hereditary xanthine oxidase deficiency consisting of at least two subgroups. Advances in experimental medicine and biology, 1989, Volume: 253A Topics: Adult; Allopurinol; Female; Genetic Variation; Humans; Pyrazinamide; Xanthine Oxidase	1989
Metabolism of pyrazinamide and allopurinol in hereditary xanthine oxidase deficiency. Clinica chimica acta; international journal of clinical chemistry, 1989, Feb-28, Volume: 180, Issue:2 Topics: Adult; Allopurinol; Female; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Xanthines	1989
Interaction between allopurinol and pyrazinamide. The European respiratory journal, 1988, Volume: 1, Issue:9 Topics: Adult; Allopurinol; Drug Interactions; Drug Therapy, Combination; Humans; Joint Diseases; Male; Pain; Pyrazinamide; Tuberculosis, Pulmonary; Uric Acid	1988
Study of the metabolism of pyrazinamide using a high-performance liquid chromatographic analysis of urine samples. Analytical biochemistry, 1987, Feb-01, Volume: 160, Issue:2 Topics: Allopurinol; Chromatography, High Pressure Liquid; Humans; Pyrazinamide; Xanthine Oxidase; Xanthines	1987
In vitro conversion of pyrazinamide into 5-hydroxypyrazinamide and that of pyrazinoic acid into 5-hydroxypyrazinoic acid by xanthine oxidase from human liver. Biochemical pharmacology, 1987, Oct-01, Volume: 36, Issue:19 Topics: Humans; Liver; NAD; Pyrazinamide; Xanthine Oxidase	1987
Separation of hypoxanthine and xanthine from pyrazinamide and its metabolites in plasma and urine by high-performance liquid chromatography. Journal of chromatography, 1986, Oct-31, Volume: 382 Topics: Biotransformation; Chromatography, High Pressure Liquid; Humans; Hypoxanthine; Hypoxanthines; Pyrazinamide; Spectrum Analysis; Xanthine; Xanthine Oxidase; Xanthines	1986
Pharmacology of pyrazinamide: metabolic and renal function studies related to the mechanism of drug-induced urate retention. The Journal of pharmacology and experimental therapeutics, 1972, Volume: 180, Issue:2 Topics: Adsorption; Allopurinol; Animals; Biological Transport, Active; Biotransformation; Carboxylic Acids; Colorimetry; Dogs; Female; Filtration; Haplorhini; Humans; Inulin; Kidney; Kidney Function Tests; Kidney Tubules; Male; Metabolism; Pyrazinamide; Pyrazines; Uric Acid; Uricosuric Agents	1972
Hyperuricemia induced by ethambutol. Advances in experimental medicine and biology, 1974, Volume: 41 Topics: Allopurinol; Creatinine; Diuretics; Ethambutol; Ethanol; Gout; Humans; Isoniazid; Lactates; Pyrazinamide; Pyridoxine; Salicylates; Stimulation, Chemical; Streptomycin; Time Factors; Tuberculosis; Uric Acid	1974
Diminished renal urate secretion per nephron as a basis for primary gout. Annals of internal medicine, 1970, Volume: 73, Issue:3 Topics: Adult; Allopurinol; Carbon Isotopes; Computers; Dietary Proteins; Gout; Humans; Inulin; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Male; Pyrazinamide; Radioisotope Dilution Technique; Spectrophotometry; Statistics as Topic; Urate Oxidase; Uric Acid	1970
Uric acid in advanced renal failure. Clinical science, 1972, Volume: 43, Issue:3 Topics: Absorption; Adult; Allopurinol; Biological Transport; Chronic Disease; Glomerular Filtration Rate; Humans; Inulin; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Tubules; Middle Aged; Pyrazinamide; Uremia; Uric Acid; Uricosuric Agents	1972
The renal mechanism for urate homeostasis in normal man. The American journal of medicine, 1967, Volume: 43, Issue:6 Topics: Adult; Allopurinol; Asian People; Biological Transport; Female; Glomerular Filtration Rate; Homeostasis; Humans; Kidney; Kidney Function Tests; Male; Pyrazinamide; Uric Acid; White People	1967
In vitro biotransformation of pyrazinamide by rat liver: identification of a new metabolite. Pharmacological research communications, 1981, Volume: 13, Issue:4 Topics: Animals; Biotransformation; Chromatography, Thin Layer; Hydroxylation; In Vitro Techniques; Liver; Male; Mass Spectrometry; Pyrazinamide; Rats; Rats, Inbred Strains; Xanthine Oxidase	1981
[Allopurinol hypersensitivity. A possible cause of hepatitis and mucocutaneous eruptions in a patient undergoing antitubercular treatment]. Revue des maladies respiratoires, 1995, Volume: 12, Issue:3 Topics: Adult; Allopurinol; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitivity; Drug Interactions; Humans; Male; Pyrazinamide; Tuberculosis, Pulmonary; Uric Acid	1995
In vitro and in vivo study on the conversion of allopurinol and pyrazinamide. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Allopurinol; Animals; Biotransformation; Liver; Male; Oxidation-Reduction; Oxypurinol; Pyrazinamide; Rats; Rats, Wistar; Triazines; Xanthine Dehydrogenase; Xanthine Oxidase	1994
In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochemical pharmacology, 1993, Sep-14, Volume: 46, Issue:6 Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Allopurinol; Animals; Benzamidines; In Vitro Techniques; Liver; Male; Oxidation-Reduction; Oxypurinol; Pyrazinamide; Rats; Rats, Wistar; Triazines	1993
Effect of BOF-4272 on the oxidation of allopurinol and pyrazinamide in vivo. Is xanthine dehydrogenase or aldehyde oxidase more important in oxidizing both allopurinol and pyrazinamide? Biochemical pharmacology, 1993, Dec-14, Volume: 46, Issue:12 Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Allopurinol; Animals; Hypoxanthine Phosphoribosyltransferase; Male; Oxidation-Reduction; Oxypurinol; Pyrazinamide; Rats; Rats, Wistar; Triazines; Xanthine Dehydrogenase	1993
Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. Journal of ethnopharmacology, 2009, Jul-15, Volume: 124, Issue:2 Topics: Animals; Disease Models, Animal; Drug Synergism; Gout Suppressants; Hyperuricemia; Inhibitory Concentration 50; Lignans; Male; Molecular Structure; Phyllanthus; Phytotherapy; Plant Extracts; Plant Leaves; Pyrazinamide; Rats; Rats, Sprague-Dawley; Uric Acid; Urine; Xanthine Oxidase	2009
Xanthine oxidase inhibition by allopurinol increases in vitro pyrazinamide-induced hepatotoxicity in HepG2 cells. Drug and chemical toxicology, 2010, Volume: 33, Issue:3 Topics: Allopurinol; Antitubercular Agents; Area Under Curve; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Synergism; Enzyme Inhibitors; Hep G2 Cells; Humans; Pyrazinamide; Statistics, Nonparametric; Xanthine Oxidase	2010
Paradoxical increase in uric acid level with allopurinol use in pyrazinamide-induced hyperuricaemia. Singapore medical journal, 2013, Volume: 54, Issue:6 Topics: Adult; Allopurinol; Arthritis, Psoriatic; Humans; Hyperuricemia; Male; Pyrazinamide; Treatment Outcome; Tuberculosis, Miliary; Uric Acid	2013
Is Hyperuricemia Overlooked when Treating Pediatric Tuberculosis Patients with Pyrazinamide? Journal of tropical pediatrics, 2015, Volume: 61, Issue:5 Topics: Adolescent; Allopurinol; Antitubercular Agents; Child; Child, Preschool; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hyperuricemia; Male; Mycobacterium tuberculosis; Pyrazinamide; Retrospective Studies; Treatment Outcome; Tuberculosis; Uric Acid	2015