putrescine and mdl 72527

putrescine has been researched along with mdl 72527 in 73 studies

Research

Studies (73)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (8.22)	18.7374
1990's	29 (39.73)	18.2507
2000's	25 (34.25)	29.6817
2010's	11 (15.07)	24.3611
2020's	2 (2.74)	2.80

Authors

Authors	Studies
Bowlin, TL; Flescher, E; Talal, N	2
Brunton, VG; Grant, MH; Wallace, HM	1
Cipolla, B; Guillé, F; Havouis, R; Lobel, B; Martin, C; Moulinoux, JP; Quemener, V; Seiler, N	1
Nakamura, Y; Shinki, T; Suda, T; Takito, J; Tanaka, H; Yamaguchi, A; Yoshiki, S	1
Elzinga, H; Hessels, J; Kingma, AW; Muskiet, FA; Sturkenboom, MC; van den Berg, GA	1
Knödgen, B; Moulinoux, JP; Quemener, V; Sarhan, S; Seiler, N	1
Hessels, J; Kingma, AW; Muskiet, FA; Sarhan, S; Seiler, N	1
Grauffel, C; Jones, R; Knödgen, B; Moulinoux, JP; Sarhan, S; Seiler, N	1
Cocchiara, G; Colombo, M; Dostert, P; Strolin Benedetti, M	1
Brasitus, TA; Chowdhury, LN; Davidson, NO; Dudeja, PK; Halline, AG; Jacoby, RF; Llor, X; Teng, BB	1
Ferwerda, H; Hessels, J; Kingma, AW; Muskiet, FA	1
Kadofuku, T; Sato, T; Shinki, T; Suda, T; Tanaka, H	1
Bansal, VS; Hattori, H; Kanfer, JN; Orihel, D	1
Bolkenius, FN; Seiler, N	1
Gerhart, F; Knödgen, B; Sarhan, S; Seiler, N	1
Bey, P; Bolkenius, FN; Seiler, N	1
Doyle, KM; Shaw, GG	1
Baudry, M; Najm, I	1
Kierszenbaum, F; Majumder, S	1
Fölsch, UR; Löser, C	1
Blanchard, Y; Chamaillard, L; Cipolla, B; Guillé, F; Havouis, R; Moulinoux, JP; Quemener, V	1
Hunter, KJ; Müller, S; Walter, RD	1
Bansard, JY; Catros-Quemener, V; Chamaillard, L; Commeurec, A; Delcros, JG; Desury, D; Genetet, N; Havouis, R; Moulinoux, JP	1
Casero, RA; Ha, HC; Woster, PM; Yager, JD	1
Hu, RH; Pegg, AE	1
Arakawa, T; Hasuma, T; Kobayashi, K; Matsui-Yuasa, I; Otani, K; Otani, S; Yano, Y	1
Farheen, S; Kitchlu, S; Mehrotra, PK	1
Başkaya, MK; Dempsey, RJ; Doğan, A; Hatcher, J; Rao, AM; Rao, VL	1
Hattori, Y; Hayashi, Y; Morizumi, Y; Tanaka, J	1
Befani, O; Missiroli, F; Mondovi, B	1
Baskaya, MK; Dempsey, RJ; Doğan, A; Hatcher, J; Rao, AM; Rao, VL; Temiz, C	1
Angelini, R; Ascenzi, P; Binda, C; Coda, A; Federico, R; Mattevi, A	1
Boggs, SS; Deutsch, M; Grudziak, AG; Redgate, ES	1
Cleveland, JL; Dai, H; Kramer, DL; Murti, KG; Porter, CW; Yang, C	1
Dempsey, RJ; Doğan, A; Hatcher, JF; Rao, AM	1
Alhonen, L; Herzig, KH; Jänne, J; Keinanen, T; Parkkinen, JJ; Sinervirta, R	1
Duranton, B; Gossé, F; Raul, F; Seiler, N	1
Badolo, L; Duranton, B; Gossé, F; Raul, F; Schneider, Y; Seiler, N; Vincent, F	1
Baudry, M; Liu, R; Liu, W; Schreiber, SS	1
Casero, RA; Gerner, EW; Lawson, KR; Linehan, JA; Marek, S; Payne, CM; Woster, PM	1
Duranton, B; Raul, F; Seiler, N	1
Carnesecchi, S; Duranton, B; Gossé, F; Holl, V; Raul, F; Schneider, Y; Seiler, N	1
Fujiwara, K; Nagoshi, S; Ota, S	1
Diegelman, P; Kee, K; Kisiel, N; Kramer, DL; Merali, S; Porter, CW; Powell, CT; Vujcic, S	1
Seiler, N	1
Bellelli, A; Bianchi, M; Cavallo, S; Cervelli, M; Federico, R; Mariottini, P; Nicolini, L; Zelli, M	1
Ling, KQ; McIntire, WS; Sayre, LM; Wu, T	1
Gossé, F; Raul, F; Renault, J; Roussi, S; Seiler, N	1
Agostinelli, E; Belli, F; Palmigiani, P; Seiler, N; Tempera, G; Vedova, LD	1
Bergerat, JP; Gossé, F; Guyot, S; Mann, A; Raul, F; Roussi, S; Schoenfelder, A; Seiler, N	1
Berberich, T; Kusano, T; Mitsuya, Y; Miyazaki, A; Takahashi, H; Takahashi, Y; Uehara, Y	1
Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD	1
Agostinelli, E; Arancia, G; Belli, F; Condello, M; Seiler, N; Vedova, LD	1
Aoudé-Werner, D; Geoffroy, P; Gossé, F; Marchioni, E; Miesch, M; Raul, F; Roussi, S; Zhang, X	1
Agostinelli, E; Arancia, G; Condello, M; Dalla Vedova, L; Tempera, G	1
Alm, K; Dahlberg, E; Holst, CM; Johansson, VM; Myhre, L; Oredsson, SM; Söderstjerna, E	1
Foltzer-Jourdainne, C; Gossé, F; Habold, C; Lobstein, A; Maldonado-Celisa, ME; Raul, F; Roessner, A; Roussia, S; Schneider-Stock, R	1
Alhonen, L; Cerrada-Gimenez, M; Jänne, J; Keinänen, TA; Khomutov, AR; Pietilä, M; Pirinen, E; Uimari, A; Vuohelainen, S	1
Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N	1
Amlong, CA; Basu, HS; Church, DR; Clower, CC; Lindstrom, MJ; Martin, CT; Mehraein-Ghomi, F; Thompson, TA; Wilding, G; Woster, PM	1
Alhonen, L; Amlal, H; Barone, S; Jänne, J; Kramer, DL; Porter, CW; Soleimani, M; Zahedi, K	1
Ikeguchi, Y; Ishii, I; Mano, H; Pegg, AE; Shirahata, A; Wada, M	1
Casero, RA; Destefano Shields, CE; Goodwin, AC; Hacker-Prietz, A; Huso, DL; Murray-Stewart, TR; Rabizadeh, S; Sears, CL; Woster, PM; Wu, S; Wu, X	1
Angelucci, E; Cervelli, M; Federico, R; Fiorucci, L; Mariottini, P; Polticelli, F	1
DeFeo-Mattox, K; Gilmour, SK; Hayes, CS; Woster, PM	1
Agostinelli, E; Arisan, ED; Bolkent, S; Calcabrini, A; Obakan, P; Palavan-Unsal, N	1
Agostinelli, E; Bonaiuto, E; Colone, M; Di Paolo, ML; Grancara, S; Macone, A; Martinis, P; Stevanato, R; Stringaro, A; Toninello, A; Vianello, F	1
Cao, H; Chen, H; Gawaz, M; Heinzmann, D; Lang, F; Liu, G; Umbach, AT	1
Caldwell, RB; Caldwell, RW; Lucas, R; Narayanan, SP; Patel, C; Shosha, E; Xing, J; Xu, Z	1
Aagaard, A; Barlind, L; Fjellström, O; Kaminski, TP; Kashima, A; Kumanomidou, T; Sjögren, T; Snijder, A; Wassvik, CM; Yokota, T	1
Igarashi, K; Leo, VI; Lim, TC; Shi, M; Sridharan, A; Subramaniam, N; Tan, NS; Tien Guan, ST; Uemura, T; Vardy, LA	1
Alfarhan, M; Liu, F; Narayanan, SP; Pichavaram, P; Shan, S; Somanath, PR	1

Reviews

2 review(s) available for putrescine and mdl 72527

Article	Year
The polyamine oxidase inactivator MDL 72527. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 2002, Volume: 59 Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Humans; Immune System; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine	2002
How important is the oxidative degradation of spermine?: minireview article. Amino acids, 2004, Volume: 26, Issue:4 Topics: Animals; Erythrocytes; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine	2004

Other Studies

71 other study(ies) available for putrescine and mdl 72527

Article	Year
Regulation of IL-2 production by mononuclear cells from rheumatoid arthritis synovial fluids. Clinical and experimental immunology, 1992, Volume: 87, Issue:3 Topics: Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Female; Humans; Interleukin-2; Male; Middle Aged; Monocytes; Ornithine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Prostaglandin Antagonists; Putrescine; Synovial Fluid	1992
Mechanisms of spermine toxicity in baby-hamster kidney (BHK) cells. The role of amine oxidases and oxidative stress. The Biochemical journal, 1991, Nov-15, Volume: 280 ( Pt 1) Topics: Animals; Carmustine; Catalase; Cell Line; Cell Survival; Cricetinae; Glutathione Reductase; Guanidines; Kidney; Kinetics; Models, Biological; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Spermine	1991
The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation. The Journal of urology, 1991, Volume: 146, Issue:5 Topics: Adenocarcinoma; Animals; Diet; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Eflornithine; Male; Neomycin; Neoplasm Transplantation; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Prostatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains	1991
Putrescine is involved in the vitamin D action in chick intestine. Gastroenterology, 1991, Volume: 100, Issue:1 Topics: Acetyltransferases; Alkaline Phosphatase; Animals; Calcium; Chick Embryo; Chickens; Duodenum; Eflornithine; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Vitamin D	1991
Gas chromatographic determination of N-acetylisoputreanine-gamma-lactam, a unique catabolite of N1-acetylspermidine. Journal of chromatography, 1991, Jan-18, Volume: 563, Issue:1 Topics: Animals; Chromatography, Gas; Female; Guanidines; Humans; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Pyrrolidinones; Rats; Rats, Inbred Strains; Reference Values; Spermidine; Swine	1991
On the degradation and elimination of spermine by the vertebrate organism. The International journal of biochemistry, 1991, Volume: 23, Issue:5-6 Topics: Animals; Erythrocytes; Female; Kinetics; Male; Mice; Mice, Inbred C57BL; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine	1991
Growth inhibition of two solid tumors in mice, caused by polyamine depletion, is not attended by alterations in cell-cycle phase distribution. International journal of cancer, 1991, Jul-09, Volume: 48, Issue:5 Topics: Animals; Cell Cycle; Cell Division; Eflornithine; Female; Fibrosarcoma; Kinetics; Lung Neoplasms; Mice; Mice, Inbred C57BL; Polyamines; Putrescine; Sarcoma, Experimental	1991
Endogenous and exogenous polyamines in support of tumor growth. Cancer research, 1990, Aug-15, Volume: 50, Issue:16 Topics: Animals; Antineoplastic Agents; Cell Division; Eflornithine; Female; Leukocyte Count; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine	1990
Does FAD-dependent polyamine oxidase contribute to the metabolism of milacemide? Journal of neural transmission. Supplementum, 1990, Volume: 32 Topics: Acetamides; Animals; Flavin-Adenine Dinucleotide; Glycine; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Pargyline; Polyamine Oxidase; Putrescine; Rats; Rats, Inbred Strains; Selegiline	1990
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine. Carcinogenesis, 1990, Volume: 11, Issue:12 Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenocarcinoma; Animals; Base Sequence; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Genes, ras; Male; Molecular Sequence Data; Neoplasms, Experimental; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polymerase Chain Reaction; Putrescine; Rats; Rats, Inbred Strains	1990
Inhibition of polyamine oxidase in rats improves the sensitivity of urinary polyamines as markers for cell death. The Biochemical journal, 1990, Mar-15, Volume: 266, Issue:3 Topics: Animals; Biomarkers, Tumor; Carbon Tetrachloride; Cell Survival; Female; Humans; Leukemia, Myeloid; Liver; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Rats, Inbred Strains	1990
Major pathway for putrescine synthesis induced by 1 alpha,25-dihydroxyvitamin D3 in chick duodenum. Gastroenterology, 1989, Volume: 96, Issue:6 Topics: Acetyltransferases; Animals; Calcitriol; Chickens; Duodenum; In Vitro Techniques; Male; Ornithine; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine	1989
Polyamine oxidation down-regulates IL-2 production by human peripheral blood mononuclear cells. Journal of immunology (Baltimore, Md. : 1950), 1989, Feb-01, Volume: 142, Issue:3 Topics: Adult; Cell Membrane; Female; Humans; Hydrogen Peroxide; Interleukin-2; Leukocytes, Mononuclear; Male; Middle Aged; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; T-Lymphocytes	1989
Distribution of selected phospholipid modifying enzymes in rat brain microsomal subfractions prepared by density gradient zonal rotor centrifugation. Neurochemical research, 1985, Volume: 10, Issue:4 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; 5'-Nucleotidase; Acetylcholinesterase; Animals; Brain; Cytidine Diphosphate Choline; Diacylglycerol Cholinephosphotransferase; Microsomes; NADPH-Ferrihemoprotein Reductase; Nucleotidases; Putrescine; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase	1985
The role of polyamine reutilization in depletion of cellular stores of polyamines in non-proliferating tissues. Biochimica et biophysica acta, 1987, Jan-20, Volume: 923, Issue:1 Topics: Amino Acids; Animals; Brain; Eflornithine; Kidney; Liver; Male; Mice; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Spermidine	1987
Chain-fluorinated polyamines as tumor markers. II. Metabolic aspects in normal tissues. Journal of cancer research and clinical oncology, 1988, Volume: 114, Issue:1 Topics: Animals; Biomarkers, Tumor; Eflornithine; Fluorine; Half-Life; Mice; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine	1988
Specific inhibition of polyamine oxidase in vivo is a method for the elucidation of its physiological role. Biochimica et biophysica acta, 1985, Jan-28, Volume: 838, Issue:1 Topics: Animals; Brain; Carbon Tetrachloride; Dose-Response Relationship, Drug; Kidney; Kinetics; Liver; Male; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine	1985
The mechanism of the neurotoxic effects of spermidine. Biochemical Society transactions, 1994, Volume: 22, Issue:4 Topics: Animals; Cerebral Ventricles; Dizocilpine Maleate; Guanidines; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurotoxins; Oxidoreductases Acting on CH-NH Group Donors; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Stereotyped Behavior	1994
Kainate-induced seizure activity stimulates the polyamine interconversion pathway in rat brain. Neuroscience letters, 1994, Apr-25, Volume: 171, Issue:1-2 Topics: Acetylation; Acetyltransferases; Animals; Biogenic Polyamines; Brain; Brain Chemistry; Kainic Acid; Male; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Rats; Rats, Sprague-Dawley; Seizures; Spermidine; Spermine	1994
N,N'-thiophene-substituted polyamine analogs inhibit mammalian host cell invasion and intracellular multiplication of Trypanosoma cruzi. Molecular and biochemical parasitology, 1993, Volume: 60, Issue:2 Topics: Animals; Cell Division; Chagas Disease; Heart; Host-Parasite Interactions; Kinetics; Mice; Mice, Inbred ICR; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Thiophenes; Trypanosoma cruzi; Virulence	1993
Importance of various intracellular regulatory mechanisms of polyamine metabolism in camostate-induced pancreatic growth in rats. Digestion, 1993, Volume: 54, Issue:4 Topics: Amine Oxidase (Copper-Containing); Animals; Biogenic Polyamines; Eflornithine; Esters; Gabexate; Guanidines; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Pancreas; Putrescine; Rats; Rats, Wistar; Time Factors; Trypsin Inhibitors	1993
In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide. Urological research, 1996, Volume: 24, Issue:2 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Eflornithine; Lung Neoplasms; Male; Metronidazole; Neomycin; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Prostatic Neoplasms; Protein Synthesis Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Survival Rate	1996
Effect of haloallylamines on polyamine oxidase activity and spermine levels in Ascaris suum. Parasitology research, 1996, Volume: 82, Issue:6 Topics: Allylamine; Animals; Antinematodal Agents; Ascaris suum; Monoamine Oxidase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermine	1996
Polyamine deprivation prevents the development of tumour-induced immune suppression. British journal of cancer, 1997, Volume: 76, Issue:3 Topics: Animals; Carcinoma, Lewis Lung; Dinoprostone; Eflornithine; Enzyme Inhibitors; Immune Tolerance; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Organ Size; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Spleen; T-Lymphocytes	1997
The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proceedings of the National Academy of Sciences of the United States of America, 1997, Oct-14, Volume: 94, Issue:21 Topics: Acetyltransferases; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Catalase; DNA Fragmentation; DNA, Neoplasm; Humans; Lung Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Putrescine; Tumor Cells, Cultured	1997
Rapid induction of apoptosis by deregulated uptake of polyamine analogues. The Biochemical journal, 1997, Nov-15, Volume: 328 ( Pt 1) Topics: Alkylation; Animals; Apoptosis; Cell Death; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Eflornithine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Putrescine; Spermidine; Spermine	1997
Polyamine metabolism of rat gastric mucosa after oral administration of hypertonic sodium chloride solution. The American journal of physiology, 1998, Volume: 274, Issue:2 Topics: Acetyltransferases; Administration, Oral; Animals; DNA Replication; Eflornithine; Enzyme Inhibitors; Gastric Mucosa; Male; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Rats, Wistar; Saline Solution, Hypertonic	1998
Effect of inhibitors of enzymes involved in polyamine biosynthesis pathway on pregnancy in mouse and hamster. Contraception, 1998, Volume: 57, Issue:1 Topics: Adenosylmethionine Decarboxylase; Animals; Cricetinae; Dose-Response Relationship, Drug; Embryo Implantation; Enzyme Inhibitors; Female; Injections, Subcutaneous; Male; Mesocricetus; Mice; Organic Chemicals; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Pregnancy; Pregnancy, Animal; Putrescine; Time Factors; Trophoblasts; Uterus	1998
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. Journal of neurochemistry, 1999, Volume: 72, Issue:2 Topics: Animals; Arterial Occlusive Diseases; Blood Gas Analysis; Blood Pressure; Body Temperature; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Injections, Intraperitoneal; Male; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Rats, Inbred SHR; Water	1999
Pentylenetetrazol-induced kindling stimulates the polyamine interconversion pathway in rat brain. Brain research, 1999, May-15, Volume: 828, Issue:1-2 Topics: Animals; Brain Chemistry; Brain Stem; Cerebral Cortex; Convulsants; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Neurons; Oxidoreductases Acting on CH-NH Group Donors; Pentylenetetrazole; Polyamines; Putrescine; Rats; Rats, Wistar	1999
Histaminase (diamine oxidase) activity in human cataract. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 1 Topics: Amine Oxidase (Copper-Containing); Amino Acid Oxidoreductases; Cataract; Enzyme Inhibitors; Humans; Lens, Crystalline; Middle Aged; Pargyline; Putrescine; Semicarbazides	1999
Contribution of polyamine oxidase to brain injury after trauma. Journal of neurosurgery, 1999, Volume: 90, Issue:6 Topics: Animals; Body Water; Brain; Brain Injuries; Enzyme Inhibitors; Male; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley	1999
A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase. Structure (London, England : 1993), 1999, Mar-15, Volume: 7, Issue:3 Topics: Amino Acid Sequence; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Flavin-Adenine Dinucleotide; Glycosylation; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Monoamine Oxidase; Oxidoreductases Acting on CH-NH Group Donors; Plant Proteins; Polyamine Oxidase; Polyamines; Protein Conformation; Protein Processing, Post-Translational; Putrescine; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Zea mays	1999
Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway. Journal of neuro-oncology, 1999, Volume: 42, Issue:2 Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Body Weight; Brain Neoplasms; Corpus Striatum; Deoxyadenosines; Eflornithine; Enzyme Inhibitors; Gliosarcoma; Infusions, Parenteral; Male; Oxidoreductases Acting on CH-NH Group Donors; Putrescine; Rats; Rats, Inbred F344; Spermidine; Tritium; Tumor Cells, Cultured	1999
The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects. Cancer research, 1999, Oct-01, Volume: 59, Issue:19 Topics: Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Eflornithine; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Lysosomes; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Proto-Oncogene Proteins c-bcl-2; Putrescine; Spermidine; Spermine	1999
Elevated N1-acetylspermidine levels in gerbil and rat brains after CNS injury. Journal of neurochemistry, 2000, Volume: 74, Issue:3 Topics: Animals; Arterial Occlusive Diseases; Blood-Brain Barrier; Brain; Brain Injuries; Cerebral Arteries; Gerbillinae; Ischemic Attack, Transient; Male; Prosencephalon; Putrescine; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Reperfusion Injury; Spermidine	2000
Activation of polyamine catabolism in transgenic rats induces acute pancreatitis. Proceedings of the National Academy of Sciences of the United States of America, 2000, Jul-18, Volume: 97, Issue:15 Topics: Acetyltransferases; Acute Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; Enzyme Induction; Female; Male; Mice; Oxidoreductases Acting on CH-NH Group Donors; Pancreas; Pancreatitis; Polyamine Oxidase; Polyamines; Putrescine; Rats; Rats, Wistar; Spermine; Zinc	2000
Spermine cytotoxicity to human colon carcinoma-derived cells (CaCo-2). Cell biology and toxicology, 2000, Volume: 16, Issue:2 Topics: Apoptosis; Caco-2 Cells; Cell Differentiation; DNA Fragmentation; G2 Phase; Humans; Mitosis; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermine	2000
Effect of the polyamine oxidase inactivator MDL 72527 on N(1)-(n-octanesulfonyl)spermine toxicity. The international journal of biochemistry & cell biology, 2000, Volume: 32, Issue:10 Topics: Amine Oxidase (Copper-Containing); Animals; Caco-2 Cells; Calmodulin; Cell Cycle; Cell Death; Drug Synergism; Eflornithine; Guanidines; Humans; Molecular Structure; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Spermine; Sulfonamides; Trifluoperazine; Tumor Cells, Cultured	2000
Role of polyamine metabolism in kainic acid excitotoxicity in organotypic hippocampal slice cultures. Journal of neurochemistry, 2001, Volume: 79, Issue:5 Topics: Animals; Biogenic Polyamines; Blotting, Western; Cell Death; Cyclosporine; Cytochrome c Group; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; Immunosuppressive Agents; Kainic Acid; Lipid Peroxidation; Neuroglia; Neuroprotective Agents; Organ Culture Techniques; Organometallic Compounds; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Rats; Reactive Oxygen Species; Salicylates	2001
Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:5 Topics: Animals; Cell Division; Cell Survival; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Microscopy, Electron; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Time Factors; Tumor Cells, Cultured	2002
Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620. Cell biology and toxicology, 2002, Volume: 18, Issue:6 Topics: Biogenic Polyamines; Cell Cycle; Cell Division; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Tumor Cells, Cultured	2002
Contribution of spermidine to stimulation by hepatocyte growth factor in repair after damage of rabbit gastric mucosal cells in primary culture. Biochimica et biophysica acta, 2003, Jan-20, Volume: 1619, Issue:2 Topics: Animals; Cells, Cultured; DNA Repair; Eflornithine; Enzyme Inhibitors; Epithelial Cells; Gastric Mucosa; Hepatocyte Growth Factor; Putrescine; Rabbits; Spermidine; Wound Healing	2003
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells. The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26 Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosylmethionine Decarboxylase; Carcinoma; Cell Division; Deoxyadenosines; Eflornithine; Enzyme Inhibitors; Humans; Male; Methionine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Prostatic Neoplasms; Putrescine; RNA, Messenger; S-Adenosylmethionine; Tetracyclines; Thionucleosides; Tumor Cells, Cultured	2004
Mouse spermine oxidase: a model of the catalytic cycle and its inhibition by N,N1-bis(2,3-butadienyl)-1,4-butanediamine. Biochemical and biophysical research communications, 2004, Sep-10, Volume: 322, Issue:1 Topics: Animals; Catalysis; Computer Simulation; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Escherichia coli; Isoenzymes; Kinetics; Mice; Models, Chemical; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Protein Engineering; Putrescine; Substrate Specificity	2004
Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527. Biochemical and biophysical research communications, 2005, Jan-14, Volume: 326, Issue:2 Topics: Acetylation; Animals; Enzyme Inhibitors; Flavins; Kinetics; Mice; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spectrum Analysis; Trichloroacetic Acid	2005
Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue. International journal of oncology, 2005, Volume: 27, Issue:6 Topics: Animals; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Molecular Structure; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Putrescine; Structure-Activity Relationship	2005
Interaction of bovine serum amine oxidase with the polyamine oxidase inactivator MDL 72527. Biochemical and biophysical research communications, 2006, Feb-17, Volume: 340, Issue:3 Topics: Amine Oxidase (Copper-Containing); Animals; Benzoquinones; Cattle; Enzyme Inhibitors; Kinetics; Models, Chemical; Molecular Conformation; Oxidoreductases Acting on CH-NH Group Donors; Phenethylamines; Phenylhydrazines; Polyamine Oxidase; Protein Binding; Putrescine; Spectrophotometry; Temperature; Time Factors	2006
Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. International journal of oncology, 2006, Volume: 29, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Biflavonoids; Catechin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Humans; Hydrogen Peroxide; Malus; Neoplasm Metastasis; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Proanthocyanidins; Putrescine	2006
Identification of a novel Cys2/His2-type zinc-finger protein as a component of a spermine-signaling pathway in tobacco. Journal of plant physiology, 2007, Volume: 164, Issue:6 Topics: Amino Acid Sequence; Cell Nucleus; Green Fluorescent Proteins; Guanidines; Molecular Sequence Data; Nicotiana; Oxidation-Reduction; Oxidoreductases; Phylogeny; Plant Proteins; Polyamines; Putrescine; Sequence Alignment; Signal Transduction; Spermine; Tobacco Mosaic Virus; Transcription Factors; Up-Regulation; Zinc Fingers	2007
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochimica et biophysica acta, 2006, Volume: 1763, Issue:10 Topics: Animals; Annexin A5; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Hot Temperature; Humans; Melanoma; Microscopy, Electron; Molecular Structure; Monoamine Oxidase; Oxidation-Reduction; Putrescine; Reactive Oxygen Species; Spermine; Time Factors	2006
Sensitization of human colon adenocarcinoma cells (LoVo) to reactive oxygen species by a lysosomotropic compound. International journal of oncology, 2006, Volume: 29, Issue:4 Topics: Adenocarcinoma; Aldehydes; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemotherapy Protocols; Cattle; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Humans; Hydrogen Peroxide; Lysosomes; Putrescine; Reactive Oxygen Species; Spermine; Tumor Cells, Cultured	2006
Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol. International journal of oncology, 2006, Volume: 29, Issue:6 Topics: Biogenic Polyamines; Caco-2 Cells; Cell Death; Cell Growth Processes; Colonic Neoplasms; Drug Synergism; Flow Cytometry; Humans; Hydroxycholesterols; Putrescine; Sitosterols; Spermidine	2006
MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells. Biochemical Society transactions, 2007, Volume: 35, Issue:Pt 2 Topics: Animals; Cell Line, Tumor; Cell Survival; Humans; Lysosomes; Mitochondria; Oxidation-Reduction; Putrescine; Spermine; Vacuoles	2007
Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction. Biochemical Society transactions, 2007, Volume: 35, Issue:Pt 2 Topics: Animals; Apoptosis; Cell Cycle; Cell Death; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Humans; Polyamines; Putrescine; Spermine	2007
Modulation by polyamines of apoptotic pathways triggered by procyanidins in human metastatic SW620 cells. Cellular and molecular life sciences : CMLS, 2008, Volume: 65, Issue:9 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Enzyme Inhibitors; Histone Deacetylases; Humans; Membrane Potential, Mitochondrial; Neoplasm Metastasis; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Proanthocyanidins; Putrescine; Receptors, TNF-Related Apoptosis-Inducing Ligand; Spermidine	2008
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:6B Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Cell Proliferation; Cell Shape; Eflornithine; Fibroblasts; Gene Expression Regulation; Glucose Transporter Type 4; Isomerism; Lipid Metabolism; Mice; Organ Specificity; Putrescine; Spermidine; Time Factors	2010
Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. International journal of oncology, 2009, Volume: 35, Issue:3 Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Lysosomes; Melanoma; Microscopy, Confocal; Microscopy, Electron, Transmission; Oxidation-Reduction; Putrescine; Spermine	2009
A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer research, 2009, Oct-01, Volume: 69, Issue:19 Topics: Acetyltransferases; Adenocarcinoma; Androgens; Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Humans; Male; Mice; Mice, Transgenic; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Prostatic Neoplasms; Putrescine; Reactive Oxygen Species; RNA, Small Interfering	2009
The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury. American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:1 Topics: Acetyltransferases; Acute Disease; Animals; Creatinine; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kidney; Kidney Diseases; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; RNA, Messenger; Severity of Illness Index; Time Factors	2010
Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino acids, 2012, Volume: 42, Issue:2-3 Topics: 3T3-L1 Cells; Acetylcysteine; Adipogenesis; Animals; Biogenic Polyamines; Chromatography, High Pressure Liquid; Mice; Putrescine	2012
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-13, Volume: 108, Issue:37 Topics: Acetyltransferases; Animals; Bacterial Toxins; Bacteroides fragilis; Cell Line; Cell Proliferation; Colitis; Colonic Neoplasms; Disease Models, Animal; DNA Damage; Enzyme Induction; Epithelial Cells; Humans; Inflammation; Intestines; Mice; Mice, Inbred C57BL; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Precancerous Conditions; Putrescine; Recombinant Proteins	2011
Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine. Journal of enzyme inhibition and medicinal chemistry, 2013, Volume: 28, Issue:3 Topics: Animals; Catalytic Domain; Chlorhexidine; Enzyme Inhibitors; Mice; Models, Molecular; Molecular Docking Simulation; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Protein Conformation; Putrescine	2013
Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites. Amino acids, 2014, Volume: 46, Issue:3 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Hair Follicle; Mice; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Reactive Oxygen Species; Skin Neoplasms; Structure-Activity Relationship	2014
Activation of polyamine catabolic enzymes involved in diverse responses against epibrassinolide-induced apoptosis in LNCaP and DU145 prostate cancer cell lines. Amino acids, 2014, Volume: 46, Issue:3 Topics: Acetyltransferases; Apoptosis; Brassinosteroids; Enzyme Activation; Humans; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Receptors, Androgen; Steroids, Heterocyclic; Structure-Activity Relationship; Tumor Cells, Cultured	2014
A novel enzyme with spermine oxidase properties in bovine liver mitochondria: identification and kinetic characterization. Free radical biology & medicine, 2015, Volume: 81 Topics: Animals; Catalytic Domain; Cattle; Hydrogen Peroxide; Kinetics; Liver; Mitochondria, Liver; Osmolar Concentration; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine; Static Electricity; Substrate Specificity	2015
Effect of Lysosomotropic Polyamineoxidase Inhibitor MDL-72527 on Platelet Activation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 38, Issue:5 Topics: Aniline Compounds; Animals; Apoptosis; Blood Platelets; Calcium; Carrier Proteins; Cell Membrane; Female; Flow Cytometry; Male; Mice; Oxidoreductases Acting on CH-NH Group Donors; P-Selectin; Peptides; Phosphatidylserines; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Polyamine Oxidase; Putrescine; Reactive Oxygen Species; Xanthenes	2016
Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy. Biochimica et biophysica acta, 2016, Volume: 1862, Issue:9 Topics: Animals; Cell Death; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned; Disease Models, Animal; Enzyme Inhibitors; Female; Inflammation; Ischemia; Male; Mice; Mice, Inbred C57BL; Microglia; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Rats; Retinal Diseases; Retinal Vessels	2016
The Structure of Murine N Biochemistry, 2017, 01-24, Volume: 56, Issue:3 Topics: Aldehydes; Animals; Catalytic Domain; Gene Expression; Hydrogen Peroxide; Kinetics; Mice; Models, Molecular; Oxidation-Reduction; Oxidoreductases; Propylamines; Protein Structure, Secondary; Putrescine; Spermidine; Spermine	2017
The Polyamine Putrescine Promotes Human Epidermal Melanogenesis. The Journal of investigative dermatology, 2020, Volume: 140, Issue:10 Topics: Biogenic Polyamines; Cells, Cultured; Dicarboxylic Acid Transporters; Epidermis; Humans; Melanins; Melanocytes; Middle Aged; Mitochondrial Membrane Transport Proteins; Putrescine; Skin Pigmentation	2020
Pharmacological Inhibition of Spermine Oxidase Suppresses Excitotoxicity Induced Neuroinflammation in Mouse Retina. International journal of molecular sciences, 2022, Feb-15, Volume: 23, Issue:4 Topics: Animals; Antioxidants; Diabetic Retinopathy; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neuroinflammatory Diseases; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Retina; Signal Transduction	2022