putrescine has been researched along with eflornithine in 477 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 213 (44.65) | 18.7374 |
| 1990's | 181 (37.95) | 18.2507 |
| 2000's | 54 (11.32) | 29.6817 |
| 2010's | 21 (4.40) | 24.3611 |
| 2020's | 8 (1.68) | 2.80 |
| Authors | Studies |
|---|---|
| Twentyman, PR; Wallace, HM; Wright, KA | 1 |
| Scott, RE; Wang, H | 1 |
| Adelman, J; Hanson, S; Ullman, B | 1 |
| Allegrini, PR; Amacker, H; Bernasconi, R; Fagg, GE; Martin, P; Sauer, D | 1 |
| Di Giorgio, RM; Fabiano, C; Ientile, R; Macaione, S; Merendino, RA | 1 |
| Akedo, H; Ashida, Y; Inoue, H; Kido, J; Kinoshita, F; Nishino, M; Shinkai, K | 1 |
| Andersson, LC; Autero, M; Mustelin, T; Oetken, C; Pessa-Morikawa, T | 1 |
| Johnson, LR; McCormack, SA; Viar, MJ; Wang, JY | 1 |
| Algranati, ID; Ceriani, C; González, NS | 1 |
| Badger, B; Demers, L; Manni, A; Martel, J | 1 |
| Gunnia, UB; Thomas, T; Thomas, TJ | 1 |
| Bachrach, U; Glantz, L; Nates, JL; Shapira, Y; Shohami, E; Trembovler, V | 1 |
| Boor, PJ; Tipnis, UR | 1 |
| Coward, JK; Lakanen, JR; Pegg, AE | 1 |
| Mann, RA; Singh, AB; Singh, M; Thomas, T; Thomas, TJ | 1 |
| Basu, HS; Csokan, PP; Delcros, JG; Feuerstein, BG; Marton, LJ; Sturkenboom, MC; Szollosi, J | 1 |
| Beyer, HS; Ellefson, M; Stanley, M; Zieve, L | 1 |
| Desiderio, MA | 1 |
| Groblewski, GE; Hargittai, PT; Seidel, ER | 1 |
| Bacchi, CJ; Goldberg, B; Moharrami, MA; Yarlett, N | 1 |
| Borghgraef, R; De Smedt, H; Missiaen, L; Parys, JB; Van Den Bosch, L | 1 |
| Enomoto, M; Kinoshita, A; Nishida, Y; Pan, HO; Suzuki, F; Takigawa, M | 1 |
| Johnson, LR; Wang, JY | 2 |
| Hattori, Y; Hayashi, Y; Hori, Y | 1 |
| Herbst, EJ; Koza, RA | 1 |
| Koike, T; Shibusawa, M; Tsunoda, A; Tsunoda, Y; Yasuda, N | 1 |
| Carper, SW; Chen, JR; Fuller, DJ; Gerner, EW; Harari, PM; Tome, ME | 1 |
| Hayashi, Y | 1 |
| Chang, BK | 1 |
| Wang, M | 1 |
| Alunda, JM; Balaña Fouce, R; Escribano, MI | 1 |
| Alunda, JM; Balaña-Fouce, R; Escribano, MI | 1 |
| Heston, WD | 1 |
| Fairlamb, AH; Hunter, KJ; Strobos, CA | 1 |
| Bankston, PW; Hellerström, C; Hoftiezer, V; Sjöholm, A; Welsh, N | 1 |
| Newman, PS; Olson, JW; Soltis, EE | 1 |
| Ilett, KF; Martin, RL; Minchin, RF; Raso, A | 1 |
| Busselen, P | 1 |
| Demers, L; Kim, I; Lynch, J; Manni, A | 1 |
| Berthélémy, P; Nicolet, T; Pradayrol, L; Scemama, JL; Seva, C; Vaysse, N | 1 |
| Alison, MR; Emons, VE; Hill, SA; Maghsoudloo, M; Murphy, GM; Sarraf, CE | 1 |
| Byus, CV; Wu, VS | 1 |
| Brzozowski, T; Drozdowicz, D; Garlicki, J; Konturek, SJ; Majka, J | 1 |
| Cipolla, B; Guillé, F; Havouis, R; Lobel, B; Martin, C; Moulinoux, JP; Quemener, V; Seiler, N | 1 |
| Fike, JR; Gobbel, GT; Lamborn, K; Marton, LJ; Seilhan, TM | 1 |
| de Belleroche, J; Reed, LJ | 1 |
| Nakamura, Y; Shinki, T; Suda, T; Takito, J; Tanaka, H; Yamaguchi, A; Yoshiki, S | 1 |
| Gunnia, UB; Seibold, JR; Thomas, T; Thomas, TJ | 1 |
| Johnson, LR; McCormack, SA | 1 |
| Kovacs, JA; Lipschik, GY; Masur, H | 1 |
| Messner, RP; Thomas, TJ | 1 |
| Koyama, H; Matsui-Yuasa, I; Morii, H; Morisawa, S; Nishizawa, Y; Otani, S; Tahara, H | 1 |
| Hessels, J; Kingma, AW; Muskiet, FA; Sarhan, S; Seiler, N | 1 |
| Iwami, K; Jain, R; Johnson, LR; McCormack, S; Wang, JY | 1 |
| Eterović, VA; Ferchmin, PA | 2 |
| Carper, SW; Chen, JR; Clay, L; Fuller, DJ; Gerner, EW | 1 |
| Degnin, C; Hill, J; Morris, DR; White, MW | 1 |
| Heby, O; Nicander, B; Oredsson, SM | 1 |
| Grauffel, C; Jones, R; Knödgen, B; Moulinoux, JP; Sarhan, S; Seiler, N | 1 |
| Eloranta, TO; Hyvönen, T; Khomutov, AR; Khomutov, RM; Lapinjoki, S | 1 |
| Borghgraef, R; De Smedt, H; Geuns, J; Parys, JB; Van Den Bosch, L | 1 |
| Seidenfeld, J; Sprague, WS | 1 |
| Gallo, MA; MacKenzie, SA; Thomas, T | 1 |
| Bartholomew, M; Demers, L; Glikman, PL; Manni, A | 1 |
| Gerarden, T; Pfaller, MA; Riley, J | 2 |
| Agnati, LF; Biagini, G; Fuxe, K; Grimaldi, R; Pich, EM; Zini, I; Zoli, M | 1 |
| Dunzendorfer, U; Knöner, M | 1 |
| Bondy, SC; Emerich, D; Tilson, HA | 1 |
| Manchester, KL; Marais, A | 1 |
| Seidel, ER; Snyder, RG | 1 |
| Dröge, W; Mihm, S; Oberdorfer, F; Risso, A; Stöhr, M | 1 |
| Bartholomew, M; Demers, L; Glikman, P; Manni, A | 1 |
| Khan, AJ; Minocha, SC | 1 |
| Bukin, YV; Khomutov, AR; Khomutov, RM; Kramer, DL; Porter, CW | 1 |
| Bacchi, CJ; Bitonti, AJ; Garofalo, J; Hannan, JC; McCann, PP; Santana, A | 1 |
| Kuroiwa, Y; Numazawa, S; Oguro, T; Yoshida, T | 1 |
| Giffin, BF; McCann, PP | 2 |
| Heby, O; Holm, I; Persson, L; Stjernborg, L | 1 |
| Copeland, CB; Irsula, O; Lau, C; Luebke, RW; Riddle, MM; Rogers, RR; Smialowicz, RJ | 1 |
| Hwang, DR; Kadmon, D; Lang, LX; Mathias, CJ; Welch, MJ | 1 |
| Borghgraef, R; De Smedt, H; Geuns, J; Van den Bosch, L | 1 |
| Hyvönen, T | 1 |
| Gawel-Thompson, KJ; Greene, RM | 1 |
| Horn, Y; Marton, LJ; Spigel, L | 1 |
| Ilett, KF; Martin, RL; Minchin, RF | 1 |
| Alunda, JM; Balaña-Fouce, R; Ordóñez, D | 1 |
| Oyasu, R; Rademaker, A; Seidenfeld, J; Uchida, K | 1 |
| Ilett, KF; Martin, RL; Minchin, RF; Summers, LA | 1 |
| Cleffmann, U; Creutzfeldt, W; Fölsch, UR; Löser, C; Nustede, R | 1 |
| Park, MH | 1 |
| Berchtold, CM; Casero, RA; Celano, P; Giardiello, FM | 1 |
| Ascioti, C; Audino, MG; De Sarro, A; De Sarro, GB; Libri, V; Nisticò, G | 1 |
| Ferwerda, H; Hessels, J; Keij, J; Kingma, AW; Muskiet, FA; van den Berg, GA | 1 |
| Snyder, RD | 2 |
| Prosser, FH; Wahl, LM | 1 |
| Goldstone, AD; Koenig, H; Lu, CY | 2 |
| Andersen, B; Lundgren, DW; Moore, JJ; Moore, RM | 1 |
| Ekker, M; Sourkes, TL | 1 |
| Dascombe, MJ; Haegele, KD | 1 |
| Agnati, LF; Calza, L; Corti, A; Davalli, P; Fuxe, K; Goldstein, M; Piccinini, G; Toffano, G; Zini, I; Zoli, M | 1 |
| Erecińska, M; Pastuszko, A; Wilson, DF | 1 |
| Bondy, SC; Walker, CH | 1 |
| Autuori, F; Beninati, S; Cocuzzi, ET; Folk, JE; Piacentini, M | 1 |
| Kelleher, PJ; Moser, RP; Rosenblum, MG; Steck, PA; Yung, WK | 1 |
| Endo, Y; Matsushima, K; Onozaki, K; Oppenheim, JJ | 1 |
| Alhonen-Hongisto, L; Gahmberg, CG; Jänne, J; Jänne, OA; Kallio, A; Sinervirta, R | 1 |
| Blume, GB; Goldstone, AD; Koenig, H | 1 |
| Baylin, SB; Casero, RA; Luk, GD; Nelkin, BD | 1 |
| Clark, RS; McGovern, KA; Pegg, AE | 1 |
| Dorr, RT; Gerner, EW; Liddil, JD | 1 |
| Barranco, SC; James, E; Saydjari, R; Thompson, JC; Townsend, CM | 1 |
| Dias, JA; Swift, TA | 1 |
| Block, AL; Komar, KA; Naujokas, MF; Seidenfeld, J | 1 |
| Meilhoc, E; Moutin, MJ; Osborne, HB; Romani, BH | 1 |
| Bregman, MD; Meyskens, FL | 1 |
| Dircks, L; Grens, A; Scheffler, IE; Slezynger, TC | 1 |
| Gerner, EW; Mamont, PS | 1 |
| Boldizsár, M; Holczinger, L; Kremmer, T | 1 |
| Seidenfeld, J; Williams-Ashman, HG | 1 |
| Inaba, M; Ishimura, E; Matsui-Yuasa, I; Morii, H; Morisada, S; Morisawa, S; Nishizawa, Y; Otani, S; Yukioka, K; Yukioka, M | 1 |
| Green, CD; Hoggard, N | 1 |
| Heby, O; Kanje, M; Mamont, PS; Oredsson, SM; Wagner, J | 1 |
| Chang, ZF; Chen, KY | 1 |
| Bacchi, CJ; Bitonti, AJ; Giffin, BF; McCann, PP | 1 |
| Bremner, AF; Coombs, GH; Lockwood, BC; North, MJ | 1 |
| Berger, FG; Porter, CW | 1 |
| Kadofuku, T; Sato, T; Shinki, T; Suda, T | 1 |
| Bacchi, CJ; Giffin, BF; McCann, PP | 1 |
| Gerner, EW; Glass, JR | 1 |
| Algranati, ID; Burrone, OR; Cafferata, EG; Ferrer, MM; Medrano, EE | 1 |
| Heston, WD; Kadmon, D | 1 |
| Castilla, MJ; Klinken, SP; Thorgeirsson, SS | 1 |
| Parra, SC; Thet, LA | 1 |
| Emmett, K; Kaur, K; McCann, PP; Sjoerdsma, A; Ullman, B | 1 |
| Deen, DF; Dewey, WC; Feuerstein, BG; Marton, LJ; Mivechi, NF | 1 |
| Gallo, CJ; Herbst, EJ; Koza, RA | 1 |
| Bolkenius, FN; Seiler, N | 1 |
| Fuller, DJ; Gerner, EW | 2 |
| Phillips, MA; Wang, CC | 1 |
| Bondy, SC; Komulainen, H | 1 |
| Carson, DA; Kubota, M; Yamanaka, H | 1 |
| Bowlin, TL; McKown, BJ; Sunkara, PS | 2 |
| Haddox, MK; Maddox, AM; Orengo, I | 1 |
| Fredholm, BB; Thyberg, J | 1 |
| Niskanen, E; Wharton, WW | 1 |
| Alhonen-Hongisto, L; Jänne, J; Laine, R; Leinonen, P | 1 |
| Byers, TL; Kameji, R; Pegg, AE; Rannels, DE | 1 |
| Abu-Elheiga, L; Assaraf, YG; Bachrach, U; Desser, H; Spira, DT | 1 |
| Covey, DF; Heston, WD; Pliner, L; Russo, P; Yang, CR | 1 |
| Aslam, M; Gillham, B; Jones, M; Nicholson, S | 1 |
| Emanuelsson, H; Heby, O; Holm, I; Löwkvist, B; Oredsson, SM | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Koike, S; Kokubun, M; Ohta, M; Okui, K; Shrestha, RD; Togawa, Y | 1 |
| Katzenellenbogen, BS; Kendra, KL | 1 |
| Deen, DF; Hunter, KJ; Marton, LJ | 1 |
| Kierszenbaum, F; McCann, PP; Sjoerdsma, A; Wirth, JJ | 1 |
| Byers, TJ; Kim, BG; McCann, PP | 1 |
| Brand, K | 1 |
| Goldstone, AD; Koenig, H; Lu, CY; Trout, JJ | 1 |
| Kiang, DT; Thomas, T | 1 |
| Gerhart, F; Knodgen, B; Sarhan, S; Seiler, N | 2 |
| Dowling, RH; Hosomi, M; Lirussi, F; Murphy, GM; Stace, NH; Vaja, S | 1 |
| Gilad, GM; Gilad, VH | 1 |
| Heby, O; Holm, I; Persson, L | 1 |
| Madhubala, R; Pegg, AE; Secrist, JA | 1 |
| Matsui-Yuasa, I; Morii, H; Morisawa, S; Nishizawa, Y; Otani, S; Shibata, T; Yukioka, K | 1 |
| Garewal, HS; Gerner, EW; Roe, D; Sampliner, RE | 1 |
| Allen, ED | 1 |
| Bazzani, C; Bertolini, A; Genedani, S; Piccinini, G; Tagliavini, S | 1 |
| Charles, M; Heston, WD | 1 |
| Djuricic, B; Meese, CO; Paschen, W; Röhn, G; Schmidt-Kastner, R | 1 |
| Etheredge, SB; Humphreys, MH; Lin, SY; Marton, LJ; Ribstein, J | 1 |
| Gawel-Thompson, K; Greene, RM | 1 |
| Sjöholm, A; Welsh, N | 1 |
| Ahmed, SR; Badger, B; Bartholomew, M; Caplan, R; Luk, G; Manni, A; Rockette, H; Wright, C | 1 |
| Bjornsson, TD; Dryjski, M; Korner, G; Kuo, BS | 1 |
| Bacchi, CJ; Yarlett, N | 2 |
| Charollais, RH; Mester, J | 1 |
| Jetten, AM; Shirley, JE | 1 |
| Alhonen-Hongisto, L; Levin, VA; Marton, LJ | 1 |
| Homma, Y; Numata, I; Oyasu, R; Ozono, S; Seidenfeld, J | 1 |
| Kovach, JS; Svingen, PA | 1 |
| Herbst, EJ; Meeker, LD; Minocha, R; Ronan, AM; Thompson, HJ | 1 |
| Fujita, K; Hayashi, S; Kameji, T; Murakami, Y | 1 |
| Bacchi, CJ; Bitonti, AJ; McCann, PP; Sjoerdsma, A | 1 |
| Covey, DF; Fair, WR; Heston, WD; Uy, L | 1 |
| Pegg, AE; Shirahata, A | 1 |
| Königk, E; Putfarken, B | 1 |
| Deen, DF; Feuerstein, BG; Marton, LJ | 1 |
| Harvey, HA; Leitzel, KE; Lipton, A; Pegg, AE; Wolf, LM | 1 |
| Billgren, M; Heby, O; Oredsson, SM | 1 |
| Seidenfeld, J | 1 |
| Benrezzak, O; Morisset, J | 2 |
| Kahana, C; Nathans, D | 1 |
| Anehus, S; Heby, O; Linden, M; Oredsson, SM | 1 |
| Gurpide, E; Holinka, CF | 1 |
| Hahn, DA; Heston, WD; Kadmon, D; Mahle, C | 1 |
| Delcros, JG; Quash, G; Roch, AM | 1 |
| Jänne, J; Käpyaho, K; Kousa, M; Lauharanta, J; Linnamaa, K; Mustakallio, K | 1 |
| Jänne, J; Käpyaho, K; Kariniemi, AL; Virtanen, I | 1 |
| Roth-Schechter, BF; Sarhan, S; Seiler, N | 1 |
| Bartolome, JV; Chait, EA; Slotkin, TA; Trepanier, PA | 1 |
| Baylin, SB; Collector, MI; Luk, GD; McCann, PP; Sensenbrenner, LL; Sharkis, SJ | 1 |
| Baylin, SB; Goodwin, G; Luk, GD; Marton, LJ | 1 |
| Hölttä, E; Hovi, T; Jänne, J; Vaheri, A; Vartio, T | 1 |
| Chambaz, EM; Duperray, A; Madani, C | 1 |
| Coffino, P; Marton, LJ; McConlogue, LC | 1 |
| Algranati, ID; Goldemberg, SH; Medrano, EE | 1 |
| Fields, A; Gibson, W; Irmiere, A; LaFemina, R; van Breemen, R | 1 |
| Fout, GS; Mapoles, JE; Medappa, KC; Rueckert, RR | 1 |
| Gillin, FD; McCann, PP; Reiner, DS | 1 |
| Russell, DH | 1 |
| Kallio, A; Lyda, S; McCann, PP; Niskanen, EO; Pou, G; Thornhill, A | 1 |
| Chaney, JE; Digenis, GA; Goto, R; Kobayashi, K | 1 |
| Deen, DF; Hung, DT; Marton, LJ; Shafer, RH | 1 |
| Diekema, KA; Kingsnorth, AN; Malt, RA; McCann, PP; Russell, WE | 1 |
| Jänne, J; Käpyaho, K; Lauharanta, J | 1 |
| Abeloff, MD; Baylin, SB; Luk, GD; McCann, PP; Sharkis, SJ; Sjoerdsma, A | 1 |
| Kelly, M; McCann, PP; Schindler, J | 1 |
| Diaz-Flores, M; Durán, G; Hicks, JJ; Méndez, JD | 1 |
| Belleville, F; Brossat, B; Metz, R; Nabet, P; Straczek, J | 1 |
| Covey, DF; Fair, WR; Heston, WD; Kadmon, D | 1 |
| Bethell, DR; Erwin, BG; Pegg, AE | 1 |
| Kufe, D; Shafman, T; Sugiura, M | 1 |
| Mamont, PS; Rudkin, BB; Seiler, N | 1 |
| Jänne, J; Kallio, A; Nikula, P | 1 |
| Griffin, J; Kufe, D; Mitchell, T; Shafman, T; Sugiura, M | 1 |
| Alhonen-Hongisto, L; Deen, DF; Marton, LJ | 1 |
| Canellakis, ES; Flamigni, F; Kyriakidis, DA; Pawlak, JW | 1 |
| Cavanaugh, PF; Pavelic, ZP; Porter, CW | 1 |
| Manni, A; Wright, C | 1 |
| Buckley, AR; Karrer, FM; Putnam, CW; Rhenman, B; Steinbronn, K; Warneke, JA | 1 |
| Heby, O; Kanje, M; Oredsson, SM | 1 |
| Iwashima, A; Oku, T; Yamanishi, K | 1 |
| Bartolome, J; Persons, D; Slotkin, TA; Whitmore, WL | 1 |
| Black, O; Chang, BK; Gutman, R | 1 |
| Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW | 1 |
| Anehus, S; Heby, O; Oredsson, SM | 1 |
| Bey, P; Danzin, C; Gerhart, F; Van Dorsselaer, V | 1 |
| Anehus, S; Heby, O; Oredsson, S | 1 |
| Alhonen-Hongisto, L; Jänne, J | 1 |
| Deen, DF; Marton, LJ; Seidenfeld, J | 1 |
| Gray, JW; Marton, LJ; Seidenfeld, J | 1 |
| Fozard, JR; Grove, J; Prakash, NJ | 1 |
| Alhonen-Hongisto, L; Jänne, J; Seppänen, P | 2 |
| Deen, DF; Hung, DT; Marton, LJ; Seidenfeld, J | 1 |
| Fair, WR; Heston, WD; Lazan, DW | 1 |
| Bethell, DR; Pegg, AE | 1 |
| Persson, L | 1 |
| Pegg, AE; Pösö, H | 1 |
| Deen, DF; Marton, LJ; Oredsson, SM | 1 |
| Bethell, DR; Hibasami, H; Matsui, I; Pegg, AE | 1 |
| Erwin, BG; Florini, JR; Pegg, AE; Richman, RA; Stoscheck, CM | 1 |
| Jänne, J; Käpyaho, K; Linnamaa, K | 1 |
| Seppänen, P | 1 |
| Claverie, N; Danzin, C; Joder-Ohlenbusch, AM; Mamont, PS; Siat, M; Wagner, J | 1 |
| Boutwell, RK; Simsiman, RC; Takigawa, M; Verma, AK | 1 |
| Sunkara, PS; Verma, DS | 1 |
| Alhonen-Hongisto, L; Hölttä, E; Jänne, J; Seppänen, P | 1 |
| Barnes, GA; Bartolome, J; Lerea, L; Seidler, FJ; Slotkin, TA; Trepanier, PA; Weigel, SJ; Whitmore, WL | 1 |
| Deen, DF; Marton, LJ; Oredsson, SM; Tofilon, PJ | 1 |
| Fair, WR; Heston, WD; Kadmon, D; Lazan, DW | 1 |
| McCann, PP; Pegg, AE | 1 |
| Bradford, MM; Chapman, WL; Hanson, WL; McCann, PP; Sjoerdsma, A; Waits, VB | 1 |
| Bardocz, S | 1 |
| Algranati, ID; Davel, L; Jasnis, MA; Klein, S; Monte, M; Sacerdote de Lustig, E | 1 |
| Johnson, LR; McCormack, SA; Wang, JY | 1 |
| el-Fakahany, EE; Hu, J; Mahmoud, MI | 1 |
| Gritli-Linde, A; Linde, A; Ruch, JV | 1 |
| Calvo-Mendez, C; Guevara-Olvera, L; Ruiz-Herrera, J | 1 |
| Afzal, V; Feeney, L; Wolff, S | 1 |
| Maghsoudloo, M; Murphy, GM; Santos, AA; Stubbs, AP; Wilkinson, ML | 1 |
| Beppu, T; Hosoda, H; Niitsu, M; Samejima, K; Shirahata, A; Takahashi, N | 1 |
| Chmurzyńska, W; Grzelakowska-Sztabert, B; Manteuffel-Cymborowska, M; Peska, M | 1 |
| Bujidos, ML; Cubría, JC; Fouce, RB; Ordóñez, D; Reguera, RM | 1 |
| Lessard, M; Poulin, R; Singh, SM; Zhao, C | 1 |
| Eloranta, TO; Hyvönen, T; Keinänen, TA; Khomutov, AR; Khomutov, RM | 1 |
| Algranati, ID; Gonzalez, NS | 1 |
| Cario, AC; Fernandez, MC; Leblebicioglu, B; Marucha, PT; Walters, JD | 1 |
| Demers, L; Heitjan, D; Manni, A; Wechter, R; Wei, L | 1 |
| Abraham, JH; Schousboe, A; Seiler, N | 1 |
| Iqbal, Z; Siddiqui, F | 1 |
| Johnson, LR; Viar, MJ; Wang, JY | 1 |
| Dempsey, RJ; Hu, Y; Kindy, MS | 1 |
| Davies, PJ; Johnson, LR; McCormack, SA; Tague, L; Viar, MJ; Wang, JY | 1 |
| Byers, TL; Hu, RH; Pegg, AE; Wechter, RS | 1 |
| Bucht, E; Larsson, R; Nygren, P; Sjöholm, A; Theodorsson, E | 1 |
| Boor, PJ; Gutkowska, J; Haile, C; Tipnis, UR | 1 |
| Cremades, A; Galindo, JD; Peñafiel, R; Sánchez-Capelo, A; Tovar, A | 1 |
| Thomas, T; Thomas, TJ | 1 |
| Goldstone, AD; Iqbal, Z; Koenig, H; Lu, CY; Trout, JJ | 1 |
| Alberts, DS; Einspahr, J; Emerson, SS; Gerner, EW; Meshkinpour, H; Meyskens, FL; Pelot, D; Shassetz, LR | 1 |
| Alunda, JM; Balaña-Fouce, R; Carrera, L | 1 |
| Aziz, SM; Endean, ED; Toursarkissian, B | 1 |
| Borroni, AM; DiScenna, P; Ferchmin, PA; Morales Velez, M; Rivera, EM; Teyler, TJ | 1 |
| Carboni, S; Carter, C; Fage, D; Scatton, B; Voltz, C | 1 |
| Berezov, TT; Fedoronchuk, TV; Ianson, IaIa; Lidak, MIu; Lulle, IZh; Siatkin, SP | 1 |
| Byus, CV; Fukumoto, GH; Hawel, L; Tjandrawinata, RR | 1 |
| Ben-Hayyim, G; Damon, JP; Martin-Tanguy, J; Tepfer, D | 1 |
| Byus, CV; Hawel, L; Tjandrawinata, RR | 1 |
| Fike, JR; Gobbel, GT; Marton, LJ; Seilhan, TM | 1 |
| Ohmori, T; Okada, K; Shibata, T; Tabei, R | 1 |
| Brock, M; Henley, CM | 1 |
| Bogle, RG; Mann, GE; Morgan, DM; Pearson, JD | 1 |
| McGarrity, TJ; Peiffer, LP | 1 |
| Fölsch, UR; Löser, C | 1 |
| Schroeder, KK; Snyder, RD | 1 |
| Blachowski, S; Grzelkowska, K; Kasterka, M; Motyl, T; Sysa, P | 1 |
| Bedoya, AM; Hernandez, SM; Isola, EL; Lammel, EM; Schwarcz de Tarlovsky, MN | 1 |
| Arkhammar, P; Berggren, PO; Bokvist, K; Hallberg, A; Nilsson, T; Rorsman, P; Sjöholm, A; Welsh, M; Welsh, N | 1 |
| Eterović, VA; Ferchmin, PA; Rivera, E | 1 |
| Goldstone, AD; Iqbal, Z; Koenig, H; Lu, CY; Siddiqui, F; Trout, JJ | 1 |
| Hoffman, JL; Parekh, VV; Younoszai, MK | 1 |
| Gentry, JB; Gutkowska, J; Tipnis, UR | 1 |
| Johnson, LR; McCormack, SA; Viar, MJ | 1 |
| Boggs, SS; Deutsch, M; Floyd, KL; Grudziak, A; Redgate, ES | 1 |
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| Blanchard, Y; Chamaillard, L; Cipolla, B; Guillé, F; Havouis, R; Moulinoux, JP; Quemener, V | 1 |
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| Bass, BL; Li, L; Rao, JN; Wang, JY | 2 |
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| Hawker, JR; Kelly, KA; Li, H; Meininger, CJ; Morris, SM; Wu, G | 1 |
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| Fox, LH; Gallacher-Horley, B; Gescher, A; Howells, LM; Hudson, EA; Manson, MM | 1 |
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| Igarashi, K; Kashiwagi, K; Murozumi, K; Nishimura, K; Park, MH; Shirahata, A | 1 |
| Alexandrova, N; Berdynskykh, N; Chekhun, V; Gerner, E; Gogol, S; Ignatenko, N; Orlovsky, O; Tregubova, N; Zaletok, S | 1 |
| Hackett, DA; Manni, A; Mauger, D; Verderame, MF; Washington, S | 1 |
| Casero, RA; Davidson, NE; Huang, Y; Pledgie, A | 1 |
| Calastrini, C; Dellavia, C; Ferioli, ME; Gagliano, N; Gioia, M; Moscheni, C; Stabellini, G | 1 |
| Bonafé, F; Caldarera, CM; Farruggia, G; Flamigni, F; Guarnieri, C; Muscari, C; Stanic, I; Stefanelli, C | 1 |
| Hu, X; Manni, A; Verderame, MF; Washington, S | 1 |
| Hegardt, C; Oredsson, S; Persson, L; Rickhag, M; Takao, K | 1 |
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| Araki, N; Asakura, M; Kozaki, S; Nishimura, K; Ohnishi, Y; Samosomsuk, W; Shima, K; Yamasaki, S; Yanase, T | 1 |
| Baron, CB; Coburn, RF; Labelle, EF | 1 |
| Bruggeman, R; Demers, LM; Griffith, JW; Jun, JY; Manni, A; Verderame, MF; Washington, S | 1 |
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| Ando, A; Furuta, K; Igarashi, K; Ito, S; Kaneko, S; Maeda, M; Matsumura, M; Nishimura, K; Okuda-Ashitaka, E; Suzuki, M | 1 |
| Borzì, RM; Caldarera, CM; Cetrullo, S; Facchini, A; Flamigni, F; Guarnieri, C; Stanic', I; Tantini, B | 1 |
| Bhattacharya, S; Johnson, LR; Ray, RM | 1 |
| Palavan-Unsal, N; Tufekci, MA; Unal, M | 1 |
| Deng, XX; Liu, JH; Wang, J; Wu, XB | 1 |
| Bhagyalakshmi, N; Venkatachalam, L | 1 |
| Bordallo, C; Bordallo, J; Cantabrana, B; de Boto, MJ; Hidalgo, A; Rubín, JM; Sánchez, M; Secades, L; Velasco, L | 1 |
| Bordallo, C; Bordallo, J; Cantabrana, B; Meana, C; Méndez, M; Sánchez, M; Secades, L; Velasco, L | 1 |
| Gupta, N; Liu, P; Zhang, H | 2 |
| Alhonen, L; Cerrada-Gimenez, M; Jänne, J; Keinänen, TA; Khomutov, AR; Pietilä, M; Pirinen, E; Uimari, A; Vuohelainen, S | 1 |
| Blohm-Mangone, KA; Gerner, EW; Stringer, DE; Uemura, T | 1 |
| Chen, WP; Gerner, EW; LaFleur, BJ; McLaren, CE; Meyskens, FL; Thompson, PA; Wertheim, BC; Zell, JA | 1 |
| Gilroy, C; Olenyik, T; Ullman, B | 1 |
| Cui, YH; Gorospe, M; Liu, L; Rao, JN; Smith, A; Turner, DJ; Wang, JY; Xiao, L; Zou, T | 1 |
| Aslam, M; Rehman, R; Soomro, MS | 1 |
| Bounedjah, O; Curmi, PA; De Bandt, JP; Desforges, B; Hamon, L; Nakib, S; Pastré, D | 1 |
| Jennings, MW; Jurney, CH; Krick, EL; Lewis, JR; O'Brien, TG; Reiter, AM; Shofer, FS; Skorupski, KA | 1 |
| Forte, A; Grossi, M; Hellstrand, P; Nilsson, BO; Persson, L; Swärd, K; Turczyńska, KM | 1 |
| Bavaria, MN; Bhattacharya, S; Johnson, LR; Ray, RM; Viar, MJ | 1 |
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| Bazer, FW; Gao, H; Kong, X; Li, X; Wang, X; Wu, G; Yin, Y | 1 |
| Chen, CH; Chen, Y; Hsu, YC; Huang, YP; Lee, MJ; Lin, KL; Sie, MH; Tsai, YH; Wang, GJ | 1 |
| Alajbegovic, A; Albinsson, S; Forte, A; Grossi, M; Hellstrand, P; Nilsson, BO; Persson, L; Phanstiel, O; Rippe, C; Swärd, K | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Pasanen, M; Peräniemi, S; Ucal, S; Vepsäläinen, J; Weisell, J | 1 |
| Cordts, K; Gribbon, P; Hennig, A; Nau, WM; Nilam, M; Reinshagen, J; Schwedhelm, E | 1 |
| Crespo-Sempere, A; Estiarte, N; Marín, S; Ramos, AJ; Sanchis, V | 1 |
| Bottiglieri, T; Casero, RA; Dunworth, M; Gambello, MJ; Kapfhamer, D; Kinchen, JM; McKenna, J; Murray-Stewart, T; Wasek, B | 1 |
| Fukui, T; Rikiyama, T; Soda, K; Takao, K | 1 |
| Bachmann, AS; Bupp, CP; Rajasekaran, S; Schultz, CR | 1 |
| Akama-Garren, E; Avila-Pacheco, J; Bod, L; Christian, E; Clish, C; DeTomaso, D; Douglas, VP; Fessler, J; Haigis, M; Kaminski, J; Kuchroo, VK; Pearce, EL; Pierce, K; Puleston, D; Regev, A; Ron-Harel, N; Schellhaass, B; Schnell, A; Singh, V; Sobel, RA; Soleimani, M; Thakore, P; Wagner, A; Wang, C; Yosef, N; Zaghouani, S | 1 |
| Bachmann, AS; Bupp, CP; Edgerly, Y; Gleason, E; Junewick, J; Leimanis-Laurens, M; Prokop, JW; Rajasekaran, S; Russell, C; Shukla, A; VanSickle, EA; Wittmann, BM | 1 |
| Capellen, CC; Casero, RA; Chandra, S; Dunworth, M; Morwitzer, MJ; Ortega-Rodas, J; Tofilau, HMN | 1 |
| Cai, L; Jiang, XR; Li, XL; Wei, ZX; Zhao, XM | 1 |
| Cui, Y; Gao, C; Gao, L; Liu, J; Qin, L; Shi, C; Wu, W; Yan, Z; Zhang, Y | 1 |
| Casero, RA; DiAngelo, JR; Nowotarski, SL; Phanstiel, O; Stump, CL | 1 |
| Blanchfield, L; Cabrera, S; DiMeglio, LA; Enriquez, JR; Evans-Molina, C; Gerner, EW; Hammoud, B; Hull, A; Kulkarni, A; Long, SA; Mastracci, TL; Mastrandrea, LD; Mirmira, RG; Nakayasu, ES; Ouyang, F; Perkins, SM; Sarkar, S; Sims, EK; Tersey, SA; Webb-Robertson, BJ; Woerner, SE | 1 |
| Hashii, N; Higashi, K; Honda, T; Igarashi, K; Ishii-Watabe, A; Komeno, M; Manaka, H; Miyajima, R; Suzuki, M; Takao, K; Toida, T | 1 |
9 review(s) available for putrescine and eflornithine
| Article | Year |
|---|---|
Prostatic polyamines and polyamine targeting as a new approach to therapy of prostatic cancer.
Topics: Aziridines; Biological Transport; Cell Division; Dihydrotestosterone; Eflornithine; Guanidines; Humans; Male; Mitoguazone; Ornithine Decarboxylase; Polyamines; Prostate; Prostatic Neoplasms; Putrescine | 1991 |
Aspects of the biochemical pharmacology of methyl glyoxal bis(guanylhydrazone).
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Carnitine; Cell Division; DNA Replication; Eflornithine; Energy Metabolism; Humans; Kinetics; Leukemia; Male; Mitochondria; Mitoguazone; Nucleic Acids; Ornithine; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Polyamines; Protein Biosynthesis; Putrescine; Virus Replication | 1986 |
Polyamine metabolism and function.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Division; Eflornithine; Humans; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine | 1982 |
The role of dietary polyamines.
Topics: Cadaverine; Cell Division; Diet; Digestive System; DNA; Eflornithine; Humans; Neoplasms; Protein Biosynthesis; Putrescine; RNA; Spermidine; Spermine | 1993 |
Parasite polyamine metabolism: targets for chemotherapy.
Topics: Animals; Antiporters; Bacterial Proteins; Biological Transport; Eflornithine; Escherichia coli Proteins; Female; Humans; Ornithine; Polyamines; Putrescine; Trichomonas vaginalis; Trichomonas Vaginitis | 1994 |
Molecular mechanisms of polyamine analogs in cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Eflornithine; Humans; Molecular Conformation; Neoplasms; Polyamines; Putrescine; Spermidine; Structure-Activity Relationship | 2005 |
Polyamines and mRNA stability in regulation of intestinal mucosal growth.
Topics: 3' Untranslated Regions; Animals; Antigens, Surface; Biogenic Polyamines; Cytoplasm; Eflornithine; ELAV Proteins; ELAV-Like Protein 1; Humans; Intestinal Mucosa; Models, Biological; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proto-Oncogene Proteins c-jun; Putrescine; RNA-Binding Proteins; RNA, Messenger; Smad Proteins; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2007 |
Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells.
Topics: Amidines; Animals; Apoptosis; Biogenic Polyamines; Caspases; Cell Survival; Chondrocytes; Eflornithine; Humans; Indans; Myocytes, Cardiac; Ornithine Decarboxylase Inhibitors; Peptide Hydrolases; Putrescine; Signal Transduction; Spermidine | 2007 |
[The importance of putrescine in the human body].
Topics: Apoptosis; Cell Differentiation; Cell Division; Cell Membrane; Eflornithine; Hirsutism; Homeostasis; Humans; Ion Channels; Iron; Neoplasms; Nervous System Diseases; Ornithine Decarboxylase; Polyamines; Polyelectrolytes; Putrescine | 2014 |
8 trial(s) available for putrescine and eflornithine
| Article | Year |
|---|---|
Urinary polyamine levels in cancer patients treated with D,L-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Eflornithine; Female; Genital Neoplasms, Female; Humans; Male; Middle Aged; Polyamines; Prostatic Neoplasms; Putrescine; Random Allocation; Spermidine; Stomach Neoplasms; Time Factors | 1989 |
Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polyps.
Topics: Administration, Oral; Adult; Aged; Biogenic Polyamines; Colonic Polyps; Colorectal Neoplasms; Drug Administration Schedule; Eflornithine; Female; Humans; Intestinal Mucosa; Male; Middle Aged; Putrescine; Spermidine; Spermine | 1994 |
Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention.
Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Audiometry; Colonic Neoplasms; Double-Blind Method; Eflornithine; Female; Hearing; Humans; Intestinal Mucosa; Male; Middle Aged; Polyamines; Putrescine; Spermidine; Spermine; Time Factors; Treatment Outcome | 1998 |
Low-dose difluoromethylornithine and polyamine levels in human prostate tissue.
Topics: Administration, Oral; Antineoplastic Agents; Eflornithine; Enzyme Inhibitors; Humans; Male; Ornithine Decarboxylase Inhibitors; Polyamines; Prostate; Prostatic Neoplasms; Putrescine; Urinary Bladder Neoplasms | 1999 |
Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Eflornithine; Female; Humans; Middle Aged; Neoplasm Staging; Polyamines; Putrescine; Receptors, Estrogen; Spermidine; Spermine; Time Factors | 1999 |
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Humans; Male; Polyamines; Prostate-Specific Antigen; Prostatic Neoplasms; Putrescine; Spermidine; Spermine | 2001 |
Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma.
Topics: Adenoma; Aged; Anticarcinogenic Agents; Biomarkers, Pharmacological; Biopsy; Colonoscopy; Colorectal Neoplasms; Dinoprostone; Double-Blind Method; Drug Therapy, Combination; Eflornithine; Enzyme Inhibitors; Female; Humans; Intestinal Mucosa; Likelihood Functions; Logistic Models; Male; Middle Aged; Neoplasms, Second Primary; Polyamines; Putrescine; Rectum; Spermidine; Spermine; Sulindac; Time Factors; Treatment Outcome | 2010 |
Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Type 1; Eflornithine; Humans; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine | 2023 |
460 other study(ies) available for putrescine and eflornithine
| Article | Year |
|---|---|
Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; Cell Survival; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance; Eflornithine; Humans; In Vitro Techniques; Lung Neoplasms; Putrescine; Spermidine; Spermine | 1992 |
Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells.
Topics: 3T3 Cells; Alkaloids; Animals; Antigens, Polyomavirus Transforming; Cell Division; Cell Line, Transformed; Eflornithine; Gene Expression; Genes, jun; Genistein; GTP-Binding Proteins; Insulin; Isoflavones; Kinetics; Mice; Pertussis Toxin; Polyamines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Putrescine; Signal Transduction; Simian virus 40; Spermidine; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella | 1992 |
Amplification and molecular cloning of the ornithine decarboxylase gene of Leishmania donovani.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; DNA, Protozoan; Eflornithine; Gene Amplification; Leishmania donovani; Molecular Sequence Data; Open Reading Frames; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polymerase Chain Reaction; Putrescine; Restriction Mapping; RNA, Messenger; RNA, Protozoan; Sequence Homology, Nucleic Acid | 1992 |
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magnetic Resonance Imaging; Male; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred F344; Spermidine; Spermine | 1992 |
Polyamines are involved in retinoic acid-mediated induction of tissue transglutaminase in human peripheral blood monocytes.
Topics: Cell Differentiation; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Induction; Humans; Macrophages; Monocytes; Putrescine; Spermidine; Transglutaminases; Tretinoin | 1992 |
Putrescine-dependent invasive capacity of rat ascites hepatoma cells.
Topics: Animals; Ascites; Biogenic Polyamines; Cattle; Cells, Cultured; Eflornithine; Endothelium, Vascular; Liver Neoplasms, Experimental; Mitoguazone; Neoplasm Invasiveness; Putrescine; Rats; Tumor Cells, Cultured | 1992 |
Reduced tyrosine phosphorylation in polyamine-starved cells.
Topics: Eflornithine; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphoma, T-Cell; Phosphorylation; Polyamines; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Putrescine; Tumor Cells, Cultured; Tyrosine | 1992 |
Effect of putrescine on S-adenosylmethionine decarboxylase in a small intestinal crypt cell line.
Topics: Adenosylmethionine Decarboxylase; Animals; Asparagine; Blood; Cell Line; Eflornithine; Half-Life; Intestine, Small; Ornithine Decarboxylase; Putrescine; Rats | 1992 |
Differential regulation of putrescine uptake in Trypanosoma cruzi and other trypanosomatids.
Topics: Animals; Biological Transport; Crithidia fasciculata; Eflornithine; Homeostasis; Kinetics; Leishmania mexicana; Putrescine; Temperature; Trypanosoma cruzi | 1992 |
Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice.
Topics: Animals; Breast Neoplasms; Cell Division; Drug Resistance; Drug Screening Assays, Antitumor; Eflornithine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1992 |
Reversal of the abnormal development of T cell subpopulations in the thymus of autoimmune MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Topics: Animals; Autoimmunity; CD4-CD8 Ratio; Disease Models, Animal; Eflornithine; Lupus Erythematosus, Systemic; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; T-Lymphocyte Subsets; Thymus Gland | 1992 |
Changes in brain polyamine levels following head injury.
Topics: Animals; Body Water; Brain; Cerebral Cortex; Eflornithine; Head Injuries, Closed; Male; Motor Activity; Posture; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine; Time Factors | 1992 |
Inhibition of polyamine synthesis impairs the secretion of atrial natriuretic peptide.
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Eflornithine; Injections, Intraperitoneal; Male; Myocardium; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Radioimmunoassay; Rats; Rats, Inbred Strains; Spermidine | 1992 |
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.
Topics: Animals; Cell Division; Cell Line, Transformed; Colonic Neoplasms; Eflornithine; Humans; Leukemia L1210; Methylation; Mice; Putrescine; Spermidine; Spermine; Spermine Synthase; Substrate Specificity; Tumor Cells, Cultured | 1992 |
Differential effects of polyamine homologues on the prevention of DL-alpha-difluoromethylornithine-mediated inhibition of malignant cell growth and normal immune response.
Topics: Animals; Cell Division; Cell Line; Concanavalin A; Cytotoxicity, Immunologic; Eflornithine; Isomerism; Lymphocyte Activation; Lymphoma; Male; Mast-Cell Sarcoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polyamines; Putrescine; Spermidine; Spermine | 1992 |
Effect of polyamine depletion on chromatin structure in U-87 MG human brain tumour cells.
Topics: Brain Neoplasms; Cell Nucleus; Chromatin; Culture Media, Serum-Free; Deoxyribonuclease I; Eflornithine; Humans; Intracellular Fluid; Kinetics; Micrococcal Nuclease; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1992 |
Inhibition of increases in ornithine decarboxylase and putrescine has no effect on rat liver regeneration.
Topics: Animals; Eflornithine; Hepatectomy; Leucine; Liver; Liver Regeneration; Male; Mitotic Index; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; Putrescine; Rats; Rats, Inbred Strains; Thymidine; Time Factors | 1992 |
Opposite responses of nuclear spermidine N8-acetyltransferase and histone acetyltransferase activities to regenerative stimuli in rat liver.
Topics: Acetyltransferases; Animals; Cell Nucleus; Eflornithine; Hepatectomy; Histone Acetyltransferases; Liver; Liver Regeneration; Male; Ornithine Decarboxylase; Putrescine; Rats; Rats, Inbred Strains; Saccharomyces cerevisiae Proteins; Thymidine Kinase | 1992 |
Ca2+/calmodulin regulation of putrescine uptake in cultured gastrointestinal epithelial cells.
Topics: Animals; Biological Transport; Calcium; Calmodulin; Cell Division; Cell Line; Eflornithine; Epithelial Cells; Epithelium; Gastrointestinal Hormones; Insulin-Like Growth Factor I; Intestine, Small; Ionomycin; Putrescine; Rats; Sulfonamides; Transforming Growth Factor beta | 1992 |
Inhibition of Trichomonas vaginalis ornithine decarboxylase by amino acid analogs.
Topics: Amino Acids; Animals; Antiprotozoal Agents; Culture Media; Cycloheximide; Eflornithine; Enzyme Stability; Kinetics; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Trichomonas vaginalis | 1992 |
Transport systems for polyamines in the established renal cell line LLC-PK. Polarized expression of an Na(+)-dependent transporter.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Biological Transport; Cell Line; Cell Membrane; Eflornithine; Gentamicins; Kidney; Kinetics; Polyamines; Polylysine; Putrescine; Ruthenium Red; Sodium | 1990 |
Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro.
Topics: Animals; Cattle; Cell Division; Chick Embryo; DNA, Neoplasm; Eflornithine; Endothelium, Vascular; Melanoma, Experimental; Neovascularization, Pathologic; Ornithine Decarboxylase; Putrescine; Spermidine | 1990 |
Polyamines and ornithine decarboxylase during repair of duodenal mucosa after stress in rats.
Topics: Animals; DNA; Duodenum; Eflornithine; Intestinal Mucosa; Male; Ornithine Decarboxylase; Polyamines; Proteins; Putrescine; Rats; Rats, Inbred Strains; RNA; Spermidine; Spermine; Stress, Physiological | 1991 |
Involvement of putrescine in the development of kindled seizure in rats.
Topics: Amygdala; Animals; Brain; Eflornithine; Electroencephalography; Frontal Lobe; Kindling, Neurologic; Male; Osmolar Concentration; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Seizures | 1992 |
Deficiencies in DNA replication and cell-cycle progression in polyamine-depleted HeLa cells.
Topics: Cell Cycle; Cell Division; Cell Nucleus; DNA Polymerase II; DNA Replication; Eflornithine; HeLa Cells; Humans; Nuclear Proteins; Polyamines; Putrescine; S Phase; Spermidine; Spermine; Thymidine Monophosphate; Tritium | 1992 |
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Male; Mitomycin; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1992 |
Polyamine catabolism in rodent and human cells in culture.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Eflornithine; Hot Temperature; Humans; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Spermidine; Spermine; Tumor Cells, Cultured | 1991 |
Effects of intra-amygdaloid injections of alpha-difluoromethylornithine and putrescine on the development of electrical kindling in rats.
Topics: Amygdala; Animals; Brain; Eflornithine; Electric Stimulation; Injections; Kindling, Neurologic; Male; Osmolar Concentration; Polyamines; Putrescine; Rats; Rats, Inbred Strains | 1991 |
Inhibitory effects of a calcium antagonist on ornithine decarboxylase induction in pancreatic cancer cell lines.
Topics: Animals; Calcium; Eflornithine; Enzyme Induction; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pancreatic Neoplasms; Putrescine; Tumor Cells, Cultured; Verapamil | 1991 |
[Inhibition by polyamine biosynthesis inhibitor DFMO of the growth of transplanted human colon cancer in nude mice].
Topics: Animals; Bone Marrow; Cecal Neoplasms; Colonic Neoplasms; Eflornithine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Putrescine; Spermidine | 1991 |
Putrescine uptake regulation in response to alpha-difluoromethylornithine treatment in Leishmania infantum promastigotes.
Topics: Animals; Chromatography, High Pressure Liquid; Culture Media; Dogs; Eflornithine; Kinetics; Leishmania donovani; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Up-Regulation | 1991 |
Leishmania infantum: polyamine biosynthesis and levels during the growth of promastigotes.
Topics: Animals; Decarboxylation; Diminazene; Dogs; Eflornithine; Leishmania donovani; Methionine; Ornithine; Polyamines; Putrescine; Spermidine; Spermine; Trypanocidal Agents | 1991 |
Inhibition of polyamine biosynthesis in Crithidia fasciculata by D,L-alpha-difluoromethylornithine and D,L-alpha-difluoromethylarginine.
Topics: Agmatine; Amidinotransferases; Animals; Arginase; Arginine; Carboxy-Lyases; Crithidia; Eflornithine; Kinetics; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine | 1991 |
Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F).
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line; Cytoplasmic Granules; Eflornithine; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics; Ornithine Decarboxylase; Pancreatic Neoplasms; Pentose Phosphate Pathway; Polyamines; Putrescine; Rats; RNA, Messenger | 1991 |
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arteries; Blood Pressure; Body Weight; Desoxycorticosterone; Dose-Response Relationship, Drug; Eflornithine; Heart; Heart Rate; Hypertension; Male; Muscle, Smooth, Vascular; Nephrectomy; Nitroprusside; Norepinephrine; Organ Size; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Serotonin; Spermidine; Spermine; Tail; Time Factors; Vasoconstriction | 1991 |
Evidence for the existence of distinct transporters for the polyamines putrescine and spermidine in B16 melanoma cells.
Topics: Affinity Labels; Biological Transport; Carrier Proteins; Eflornithine; Kinetics; Melanoma, Experimental; Photochemistry; Putrescine; Spermidine; Tumor Cells, Cultured | 1991 |
Polyamines and the calcium paradox in rat hearts.
Topics: Animals; Calcium; Chromatography, High Pressure Liquid; Eflornithine; Egtazic Acid; Female; Heart; Myocardium; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine; Systole | 1991 |
Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Eflornithine; Estrogens; Humans; In Vitro Techniques; Neoplasms, Hormone-Dependent; Polyamines; Putrescine; Serum Albumin, Bovine; Spermidine; Spermine; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1991 |
Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cells, Cultured; Dexamethasone; Eflornithine; Kinetics; Male; Pancreas; Pancreatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1991 |
Effect of alpha-difluoromethylornithine on the polyamine levels and proliferation in two transplantable tumours.
Topics: Animals; Cell Division; Cell Nucleus; Eflornithine; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Microscopy, Electron; Neoplasm Transplantation; Organelles; Polyamines; Putrescine; Sarcoma, Experimental; Spermidine; Spermine | 1991 |
The level of substrate ornithine can alter polyamine-dependent DNA synthesis following phorbolester stimulation of cultured hepatoma cells.
Topics: Animals; Arginine; Blood; Clone Cells; Culture Media; DNA; Eflornithine; Insulin; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Role of polyamines and prostaglandins in gastroprotective action of epidermal growth factor against ethanol injury.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Eflornithine; Epidermal Growth Factor; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermine | 1991 |
The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation.
Topics: Adenocarcinoma; Animals; Diet; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Eflornithine; Male; Neomycin; Neoplasm Transplantation; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Prostatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains | 1991 |
Modification of radiation-induced brain injury by alpha-difluoromethylornithine.
Topics: Animals; Blood-Brain Barrier; Brachytherapy; Brain; Brain Edema; Dogs; Eflornithine; Female; Infusions, Intravenous; Iodine Radioisotopes; Male; Putrescine; Radiation Injuries, Experimental; Spermidine | 1991 |
Induction of ornithine decarboxylase in cerebral cortex by excitotoxin lesion of nucleus basalis: association with postsynaptic responsiveness and N-methyl-D-aspartate receptor activation.
Topics: Animals; Basal Ganglia; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Eflornithine; Enzyme Induction; Excitatory Amino Acid Antagonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxazoles; Pentobarbital; Phosphatidylinositol Phosphates; Phosphatidylinositols; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Substantia Innominata; Synapses | 1990 |
Putrescine is involved in the vitamin D action in chick intestine.
Topics: Acetyltransferases; Alkaline Phosphatase; Animals; Calcium; Chick Embryo; Chickens; Duodenum; Eflornithine; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Vitamin D | 1991 |
Restoration of the DNA binding activity of estrogen receptor in MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Topics: Animals; DNA; Down-Regulation; Eflornithine; Female; Lupus Erythematosus, Systemic; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Putrescine; Receptors, Estrogen; Spermidine; Spermine; Uterus | 1991 |
Putrescine uptake and release by a normal rat small intestine crypt cell line, IEC-6.
Topics: Animals; Biological Transport; Butanols; Cell Compartmentation; Detergents; Digitonin; Eflornithine; Epithelium; Glycerol; Intestinal Mucosa; Intestines; Polyethylene Glycols; Putrescine; Rats; Solubility | 1991 |
Polyamine metabolism in Pneumocystis carinii.
Topics: Animals; Arginine; Eflornithine; Lung; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pentamidine; Pneumocystis; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1991 |
Difluoromethylornithine therapy of female NZB/W mice.
Topics: Animals; Antibodies, Antinuclear; Blood Urea Nitrogen; Eflornithine; Female; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Lupus Vulgaris; Mice; Mice, Inbred BALB C; Proteinuria; Putrescine; Spermidine; Spleen | 1991 |
Role of putrescine in interleukin 1 beta production in human histiocytic lymphoma cell line U937.
Topics: Calcitriol; Cell Differentiation; Cell Division; Eflornithine; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Lymphoma, Large B-Cell, Diffuse; Monocytes; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Growth inhibition of two solid tumors in mice, caused by polyamine depletion, is not attended by alterations in cell-cycle phase distribution.
Topics: Animals; Cell Cycle; Cell Division; Eflornithine; Female; Fibrosarcoma; Kinetics; Lung Neoplasms; Mice; Mice, Inbred C57BL; Polyamines; Putrescine; Sarcoma, Experimental | 1991 |
Intestinal ornithine decarboxylase: half-life and regulation by putrescine.
Topics: Animals; Asparagine; Cell Line; Cycloheximide; Eflornithine; Homeostasis; Intestine, Small; Kinetics; Male; Ornithine Decarboxylase; Protein Binding; Putrescine; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Experience affects cortical but not subcortical polyamines.
Topics: Animals; Biogenic Polyamines; Brain; Cerebellum; Cerebral Cortex; Eflornithine; Environment; Male; Medulla Oblongata; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1990 |
Polyamine regulation of heat-shock-induced spermidine N1-acetyltransferase activity.
Topics: Acetyltransferases; Animals; Biogenic Amines; Cells, Cultured; Cricetinae; Cycloheximide; Dactinomycin; Diamines; Eflornithine; Enzyme Induction; Hot Temperature; Humans; Putrescine; Transcription, Genetic | 1990 |
Specific regulation by endogenous polyamines of translational initiation of S-adenosylmethionine decarboxylase mRNA in Swiss 3T3 fibroblasts.
Topics: Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Carboxy-Lyases; Cells, Cultured; Cytosol; Eflornithine; Fibroblasts; Gene Expression Regulation, Enzymologic; Mice; Protein Biosynthesis; Putrescine; RNA, Messenger; RNA, Ribosomal, 16S | 1990 |
Implications for a reduced DNA-elongation rate in polyamine-depleted cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Division; Deoxyribonucleotides; DNA Replication; DNA, Neoplasm; Eflornithine; Kinetics; Mice; Putrescine; Spermidine; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
Endogenous and exogenous polyamines in support of tumor growth.
Topics: Animals; Antineoplastic Agents; Cell Division; Eflornithine; Female; Leukocyte Count; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine | 1990 |
Uptake of 3H-labeled 1-aminooxy-3-aminopropane by baby hamster kidney cells.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Cricetinae; Eflornithine; Kidney; Ornithine Decarboxylase Inhibitors; Propylamines; Putrescine; Spermidine | 1990 |
Regulation of the Na(+)-dependent and the Na(+)-independent polyamine transporters in renal epithelial cells (LLC-PK1).
Topics: Animals; Biological Transport; Carrier Proteins; Cell Line; Cell Membrane; Cells, Cultured; Chromatography, High Pressure Liquid; Cycloheximide; Dactinomycin; Eflornithine; Epithelial Cells; Epithelium; Kidney; Mitoguazone; Polyamines; Putrescine; Serum Albumin, Bovine; Sodium; Spermidine; Spermine; Swine | 1990 |
Comparisons between sensitive and resistant human tumor cell lines regarding effects of polyamine depletion on chloroethylnitrosourea efficacy.
Topics: Carmustine; Cell Survival; DNA Repair; Drug Synergism; Eflornithine; Humans; In Vitro Techniques; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Polyamines; Putrescine; Streptozocin; Tumor Cells, Cultured | 1990 |
Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Topics: Animals; Ascites; Body Weight; Eflornithine; Female; Liver; Mice; Mice, Inbred Strains; Organ Size; Polyamines; Polychlorinated Dibenzodioxins; Putrescine; Spermidine; Spermine; Spleen; Thymus Gland | 1990 |
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol; Humans; Insulin-Like Growth Factor I; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1990 |
Polyamine depletion and growth inhibition of Cryptococcus neoformans by alpha-difluoromethylornithine and cyclohexylamine.
Topics: Cryptococcus neoformans; Cyclohexylamines; Dose-Response Relationship, Drug; Eflornithine; Humans; Polyamines; Putrescine; Spermidine; Spermine | 1990 |
Evidence for a role of neosynthetized putrescine in the increase of glial fibrillary acidic protein immunoreactivity induced by a mechanical lesion in the rat brain.
Topics: Animals; Astrocytes; Brain Injuries; Corpus Striatum; Eflornithine; Glial Fibrillary Acidic Protein; Male; Putrescine; Rats; Rats, Inbred Strains; Reference Values | 1990 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Carcinoma; Eflornithine; Estrogens; Humans; Male; Mitoguazone; Neoplasm Metastasis; Ornithine; Ornithine Decarboxylase Inhibitors; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatitis; Putrescine; Rats; Spermidine; Spermine | 1985 |
Inhibition of ornithine decarboxylase alters neurological responsiveness to a tremorigen.
Topics: Animals; Behavior, Animal; Chlordecone; Eflornithine; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Inbred F344; Tremor | 1986 |
Role of polyamines in experience-dependent brain plasticity.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; DNA; Eflornithine; Male; Neuronal Plasticity; Organ Size; Putrescine; Rats; Rats, Inbred Strains; RNA; Spermidine; Spermine | 1987 |
Role of polyamines and intracellular pH change in the hypertrophy of the denervated rat hemidiaphragm.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Denervation; Eflornithine; Hydrogen-Ion Concentration; Hypertrophy; Male; Muscle, Smooth; Polyamines; Putrescine; Rats; Spermidine | 1988 |
Pentagastrin induction of spermine/spermidine N1-acetyltransferase and mucosal polyamines.
Topics: Acetyltransferases; Animals; Chromatography, High Pressure Liquid; Colon; Eflornithine; Enzyme Induction; Gastric Mucosa; Intestinal Mucosa; Kinetics; Male; Parietal Cells, Gastric; Pentagastrin; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine | 1989 |
Downregulation of T cell growth factor production by ornithine decarboxylase and its product putrescine: D,L-alpha-difluoromethylornithine suppresses general protein synthesis but augments simultaneously the production of interleukin-2.
Topics: Adjuvants, Immunologic; Animals; Cell Line; Eflornithine; Glycolysis; Interleukin-2; Intracellular Fluid; Leucine; Lymphoma; Mice; Mitosis; Ornithine Decarboxylase; Protein Synthesis Inhibitors; Putrescine; RNA, Messenger; Tetradecanoylphorbol Acetate | 1989 |
Polyamine involvement in the growth of hormone-responsive and -resistant human breast cancer cells in culture.
Topics: Biogenic Polyamines; Breast Neoplasms; Cell Count; Dose-Response Relationship, Drug; Eflornithine; Female; Humans; Neoplasms, Hormone-Dependent; Ornithine Decarboxylase; Putrescine; Time Factors; Tumor Cells, Cultured | 1989 |
Biosynthetic arginine decarboxylase in phytopathogenic fungi.
Topics: Arginine; Ascomycota; Carboxy-Lyases; Eflornithine; Kinetics; Mitosporic Fungi; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermine; Xylariales | 1989 |
Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cell Survival; Deoxyadenosines; Eflornithine; Leukemia L1210; Mice; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1989 |
Trypanosoma brucei brucei: regulation of ornithine decarboxylase in procyclic forms and trypomastigotes.
Topics: Animals; Cycloheximide; Dactinomycin; Eflornithine; Enzyme Induction; Half-Life; Male; Ornithine Decarboxylase; Putrescine; Rats; Spermidine; Spermine; Trypanosoma brucei brucei | 1989 |
Comparative studies on the inducing effects of cobalt chloride and co-protoporphyrin on hepatic ornithine decarboxylase and heme oxygenase in rats.
Topics: Animals; Cobalt; Diamines; Eflornithine; Enzyme Induction; Heme Oxygenase (Decyclizing); Liver; Male; Maleates; Mixed Function Oxygenases; Ornithine Decarboxylase; Polyamines; Porphyrins; Protoporphyrins; Putrescine; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Physiological activation of the mitochondrion and the transformation capacity of DFMO induced intermediate and short stumpy bloodstream form trypanosomes.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Eflornithine; Histocytochemistry; Male; Microscopy, Electron; Mitochondria; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, African | 1989 |
Polyamine-mediated control of mammalian S-adenosyl-L-methionine decarboxylase expression: effects on the content and translational efficiency of the mRNA.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Eflornithine; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Immunosorbent Techniques; Nucleic Acid Hybridization; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Putrescine; RNA, Messenger; Spermidine | 1989 |
Suppression of lymphocyte proliferation by hexamethylene diamine.
Topics: Animals; Concanavalin A; Diamines; Eflornithine; Female; Lipopolysaccharides; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred C57BL; Mitogens; Ornithine Decarboxylase Inhibitors; Phytohemagglutinins; Putrescine; Spleen | 1989 |
N-3-[18F]fluoropropylputrescine as potential PET imaging agent for prostate and prostate derived tumors.
Topics: Animals; Carbon Radioisotopes; Cell Line; Dihydrotestosterone; Eflornithine; Humans; Male; Prostate; Prostatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Tumor Cells, Cultured | 1989 |
Polyamine transport systems in the LLC-PK1 renal epithelial established cell line.
Topics: Animals; Biogenic Polyamines; Biological Transport; Cell Differentiation; Cell Division; Cell Line; Eflornithine; Epithelial Cells; Epithelium; Kidney; Putrescine; Sodium; Spermidine; Spermine | 1989 |
Excretion of acetylated and free polyamines by polyamine depleted Chinese hamster ovary cells.
Topics: Animals; Biogenic Polyamines; Cell Division; Cell Line; Eflornithine; Putrescine; Spermidine; Spermine | 1989 |
Epidermal growth factor: modulator of murine embryonic palate mesenchymal cell proliferation, polyamine biosynthesis, and polyamine transport.
Topics: Animals; Cell Division; Cycloheximide; Dactinomycin; DNA; Dose-Response Relationship, Drug; Eflornithine; Epidermal Growth Factor; Female; Male; Mesoderm; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Polyamines; Putrescine; Time Factors | 1989 |
Paraquat is not accumulated in B16 tumor cells by the polyamine transport system.
Topics: Biological Transport; Dose-Response Relationship, Drug; Eflornithine; Kinetics; Melanoma, Experimental; Paraquat; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1989 |
Putrescine transport system in Leishmania infantum promastigotes.
Topics: Amino Acids; Animals; Biological Transport, Active; Diminazene; Eflornithine; Hydrogen-Ion Concentration; Leishmania donovani; Polyamines; Putrescine; Temperature | 1989 |
Inhibitory action of alpha-difluoromethylornithine on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Drug Administration Schedule; Eflornithine; Male; Neoplasms, Experimental; Putrescine; Rats; Rats, Inbred F344; Spermidine; Spermine; Time Factors; Urinary Bladder Neoplasms | 1989 |
Inhibition of putrescine uptake by polypyridinium quaternary salts in B16 melanoma cells treated with difluoromethylornithine.
Topics: Animals; Eflornithine; Melanoma, Experimental; Mice; Putrescine; Pyridinium Compounds; Tumor Cells, Cultured | 1989 |
Role of ornithine decarboxylase and polyamines in camostate (Foy-305)-induced pancreatic growth in rats.
Topics: Animals; Cholecystokinin; Eflornithine; Esters; Gabexate; Guanidines; Kinetics; Male; Ornithine Decarboxylase; Pancreas; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1989 |
The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities.
Topics: Animals; Cell Line; Cricetinae; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; Putrescine; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship | 1989 |
Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells.
Topics: Adenosine; Blotting, Northern; Cell Division; Cell Line; Colonic Neoplasms; Eflornithine; Gene Expression Regulation, Neoplastic; Humans; Polyamines; Proto-Oncogenes; Putrescine; RNA, Messenger; Spermidine; Spermine; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Behavioural and electrocortical effects after injection of two ornithine decarboxylase inhibitors into several areas of the brain in the rat.
Topics: Amygdala; Animals; Basal Ganglia; Behavior, Animal; Cerebral Cortex; Eflornithine; Electroencephalography; Hippocampus; Injections; Injections, Intraventricular; Male; Muscimol; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Thalamus | 1989 |
Microbial flora in the gastrointestinal tract abolishes cytostatic effects of alpha-difluoromethylornithine in vivo.
Topics: Animals; Biogenic Polyamines; Combined Modality Therapy; Deuterium; Dietary Carbohydrates; Digestive System; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eflornithine; Feces; Female; Leukemia L1210; Mice; Mice, Inbred DBA; Putrescine; Specific Pathogen-Free Organisms | 1989 |
Inhibition of X-ray-induced DNA strand break repair in polyamine-depleted HeLa cells.
Topics: DNA Repair; DNA, Neoplasm; Eflornithine; HeLa Cells; Humans; Mitoguazone; Polyamines; Putrescine; Spermidine; Spermine | 1989 |
Involvement of the ornithine decarboxylase pathway in macrophage collagenase production.
Topics: Animals; Bucladesine; Cells, Cultured; Dinoprostone; Eflornithine; Guinea Pigs; Indomethacin; Lipopolysaccharides; Macrophage Activation; Macrophages; Microbial Collagenase; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Prostaglandins E; Putrescine | 1988 |
Polyamines are intracellular messengers in the beta-adrenergic regulation of Ca2+ fluxes, [Ca2+]i and membrane transport in rat heart myocytes.
Topics: Amino Acids; Animals; Biological Transport, Active; Calcium; Eflornithine; Endocytosis; Hexoses; Isoproterenol; Myocardium; Polyamines; Putrescine; Receptors, Adrenergic, beta | 1988 |
Polyamines control human chorionic gonadotropin production in the JEG-3 choriocarcinoma cell.
Topics: Bucladesine; Cell Division; Choriocarcinoma; Chorionic Gonadotropin; Eflornithine; Humans; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; RNA, Messenger; Spermidine; Spermine; Tumor Cells, Cultured | 1988 |
Effects of alpha-difluoromethylornithine on polyamine biosynthesis and tyrosine hydroxylase induction in the adrenal gland of the rat subjected to stress or apomorphine.
Topics: Adrenal Glands; Animals; Apomorphine; Cold Temperature; Eflornithine; Enzyme Induction; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Restraint, Physical; Spermidine; Spermine; Stress, Physiological; Tyrosine 3-Monooxygenase | 1985 |
Evidence against putrescine and polyamines as endogenous mediators of fever.
Topics: Animals; Eflornithine; Endotoxins; Fever; Ornithine; Polyamines; Putrescine; Rabbits; Shigella dysenteriae; Spermidine; Spermine | 1985 |
Effects of lesions and ganglioside GM1 treatment on striatal polyamine levels and nigral DA neurons. A role of putrescine in the neurotropic activity of gangliosides.
Topics: Animals; Corpus Striatum; Dopamine; Eflornithine; G(M1) Ganglioside; Male; Neurons; Ornithine; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine 3-Monooxygenase | 1985 |
A role for transglutaminase in neurotransmitter release by rat brain synaptosomes.
Topics: Animals; Brain; Cadaverine; Catecholamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Eflornithine; gamma-Aminobutyric Acid; Male; Methylamines; Neurotransmitter Agents; Ornithine; Putrescine; Rats; Rats, Inbred Strains; Synaptosomes; Transglutaminases | 1986 |
Polyamines contribute to calcium-stimulated release of aspartate from brain particulate fractions.
Topics: Animals; Aspartic Acid; Calcium; Dopamine; Eflornithine; Frontal Lobe; gamma-Aminobutyric Acid; Male; Neurotransmitter Agents; Ornithine; Ornithine Decarboxylase; Polyamines; Potassium; Putrescine; Rats; Synaptosomes | 1986 |
Covalent incorporation of polyamines as gamma-glutamyl derivatives into CHO cell protein.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Eflornithine; Female; Mitoguazone; Ovary; Polyamines; Proteins; Putrescine; Spermidine; Spermine; Transglutaminases | 1988 |
Growth inhibitory effect of recombinant alpha and beta interferon on human glioma cells.
Topics: Binding, Competitive; Cell Division; Cell Line; Eflornithine; Glioma; Humans; Interferon Type I; Putrescine; Receptors, Immunologic; Receptors, Interferon; Recombinant Proteins; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1987 |
Role of ornithine decarboxylase in the regulation of cell growth by IL-1 and tumor necrosis factor.
Topics: Animals; Cell Division; Cell Line; DNA; Eflornithine; Glioma; Growth Inhibitors; Humans; Interleukin-1; Melanoma; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; T-Lymphocytes, Helper-Inducer; Tumor Necrosis Factor-alpha | 1988 |
Tumourigenicity, cell-surface glycoprotein changes and ornithine decarboxylase gene pattern in Ehrlich ascites-carcinoma cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; DNA, Neoplasm; Eflornithine; Electrophoresis, Polyacrylamide Gel; Gene Amplification; Glycoproteins; Membrane Proteins; Mice; Ornithine; Ornithine Decarboxylase; Phenotype; Putrescine | 1985 |
Association of increased polyamine levels with isoproterenol-stimulated mucin secretion in the rat submandibular gland.
Topics: Animals; Eflornithine; Glucosamine; Isoproterenol; L-Lactate Dehydrogenase; Male; Mucins; Ornithine; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Submandibular Gland; Time Factors | 1985 |
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
Topics: Carcinoma; Carcinoma, Small Cell; Cell Cycle; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger | 1986 |
Effect of 1,3,6-triaminohexane and 1,4,7-triaminoheptane on growth and polyamine metabolism in SV-3T3 cells treated with 2-difluoromethylornithine.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Viral; Eflornithine; Fibroblasts; Heptanes; Hexanes; Ornithine; Polyamines; Putrescine; S-Adenosylmethionine; Simian virus 40; Spermidine | 1986 |
Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines.
Topics: Animals; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Single-Stranded; Eflornithine; Etoposide; Humans; Leukemia L1210; Mice; Multiple Myeloma; Nucleic Acid Conformation; Ornithine; Podophyllotoxin; Polyamines; Putrescine | 1986 |
Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro.
Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Line; Cell Survival; Cricetinae; Cyclosporins; Drug Synergism; Eflornithine; Ornithine Decarboxylase Inhibitors; Pancreatic Neoplasms; Polyamines; Putrescine | 1986 |
Stimulation of polyamine biosynthesis by follicle-stimulating hormone in serum-free cultures of rat Sertoli cells.
Topics: Animals; Bucladesine; Cyclic AMP; Eflornithine; Estradiol; Follicle Stimulating Hormone; Male; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Sertoli Cells; Spermidine; Spermine | 1987 |
Altered cell cycle phase distributions in cultured human carcinoma cells partially depleted of polyamines by treatment with difluoromethylornithine.
Topics: Cell Cycle; Cell Line; DNA; Dose-Response Relationship, Drug; Eflornithine; Flow Cytometry; Humans; Ornithine; Polyamines; Putrescine | 1986 |
Relationship between ornithine decarboxylase activity and hexamethylene bisacetamide-induced differentiation of murine erythroleukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Cell Line; Clone Cells; Dexamethasone; Eflornithine; Erythrocytes; Interphase; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Ornithine; Ornithine Decarboxylase; Putrescine; Spermidine; Spermine | 1986 |
Difluoromethylornithine enhances inhibition of melanoma cell growth in soft agar by dexamethasone, clone A interferon and retinoic acid.
Topics: Cell Line; Cell Survival; Dexamethasone; Drug Combinations; Drug Synergism; Eflornithine; Humans; Interferon Type I; Melanoma; Ornithine; Putrescine; Tretinoin | 1986 |
Posttranscriptional regulation of ornithine decarboxylase activity.
Topics: Animals; Cell Cycle; Cell Line; Cricetinae; Cricetulus; Eflornithine; Emetine; Female; Half-Life; Ornithine; Ornithine Decarboxylase; Ovary; Protein Processing, Post-Translational; Putrescine; RNA, Messenger | 1986 |
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation.
Topics: Alkynes; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1986 |
In vivo effects of DL-alpha-difluoromethylornithine on the polyamine and nucleotide phosphate metabolism in P388/S leukemia cells.
Topics: Animals; Cell Line; Eflornithine; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleotides; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Time Factors | 1986 |
Polyamines in 1 alpha, 25-dihydroxycholecalciferol-induced differentiation of human promyelocytic leukemia cells, HL-60.
Topics: Acetyltransferases; Calcitriol; Cell Differentiation; Cell Division; Cell Line; Eflornithine; Humans; Leukemia, Myeloid; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1986 |
Polyamines and growth regulation of cultured human breast cancer cells by 17 beta-oestradiol.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Insulin; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Tamoxifen | 1986 |
Polyamine depletion increases cellular ribonucleotide levels.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Chromatography, High Pressure Liquid; Eflornithine; Mice; Ornithine; Putrescine; Rats; S-Adenosylmethionine; Spermine | 1986 |
Age dependency of the metabolic conversion of polyamines into amino acids in IMR-90 human embryonic lung diploid fibroblasts.
Topics: Amino Acids; Cell Line; Cell Survival; Diploidy; Eflornithine; Enzyme Induction; Fibroblasts; Humans; Lysine; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Processing, Post-Translational; Putrescine | 1986 |
Polyamine depletion following exposure to DL-alpha-difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Eflornithine; Male; Mitochondria; Ornithine; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Trypanosoma brucei brucei | 1986 |
Polyamine biosynthesis in trichomonads.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Culture Media; Eflornithine; Eukaryota; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine; Trichomonas vaginalis; Tritrichomonas | 1986 |
Putrescine does not mediate the androgen-response in mouse kidney.
Topics: Animals; Eflornithine; Female; Kidney; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; RNA, Messenger; Spermidine; Spermine; Testosterone | 1986 |
Spermidine N1-acetyltransferase has a larger role than ornithine decarboxylase in 1 alpha,25-dihydroxyvitamin D3-induced putrescine synthesis.
Topics: Acetyltransferases; Animals; Calcitriol; Chickens; Duodenum; Eflornithine; Epithelium; Intestinal Mucosa; Kinetics; Male; Ornithine; Ornithine Decarboxylase; Putrescine; Vitamin D Deficiency | 1986 |
Effect of putrescine on the respiration of Trypanosoma brucei brucei.
Topics: Animals; Eflornithine; Magnesium; Male; Mitochondria; Ornithine; Oxygen Consumption; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Trypanosoma brucei brucei | 1986 |
Polyamine-mediated turnover of ornithine decarboxylase in Chinese-hamster ovary cells.
Topics: Animals; Cells, Cultured; Chemical Precipitation; Cricetinae; Cricetulus; Eflornithine; Female; Immunoelectrophoresis; Ornithine; Ornithine Decarboxylase; Ovary; Peptide Fragments; Putrescine; Spermidine | 1986 |
A novel mechanism of resistance to alpha-difluoromethylornithine induced by cycloheximide. Growth with abnormally low levels of putrescine and spermidine.
Topics: Animals; Cell Line; Cycloheximide; Drug Resistance; Eflornithine; Fibroblasts; Humans; Mice; Ornithine Decarboxylase; Putrescine; Spermidine | 1986 |
alpha-Difluoromethylornithine enhancement of 14C-putrescine uptake by an androgen-dependent prostatic tumor.
Topics: Adenocarcinoma; Androgens; Animals; Carbon Radioisotopes; Dexamethasone; Dihydrotestosterone; Eflornithine; Male; Neoplasms, Hormone-Dependent; Premedication; Prostatic Neoplasms; Putrescine; Radionuclide Imaging; Rats | 1986 |
Effect of inhibitors of ornithine decarboxylase on retrovirus induced transformation of murine erythroid precursors in vitro.
Topics: Animals; Cell Division; Cell Transformation, Viral; Eflornithine; Erythrocytes; Erythropoietin; Hematopoietic Stem Cells; Mice; Ornithine Decarboxylase Inhibitors; Putrescine; Retroviridae | 1986 |
Role of ornithine decarboxylase and polyamines in early postnatal lung growth.
Topics: Animals; Animals, Newborn; DNA; Eflornithine; Lung; Organ Size; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Proteins; Putrescine; Rats; Rats, Inbred Strains; Spermidine | 1986 |
Effects of DL-alpha-difluoromethylornithine on Leishmania donovani promastigotes.
Topics: Animals; Eflornithine; Leishmania donovani; Putrescine; Spermidine; Spermine | 1986 |
Relationship between heat sensitivity and polyamine levels after treatment with alpha-difluoromethylornithine (DFMO).
Topics: Cell Division; Cells, Cultured; Eflornithine; Hot Temperature; Polyamines; Putrescine; Spermidine; Spermine | 1986 |
Polyamines and HeLa-cell DNA replication.
Topics: DNA Replication; Eflornithine; HeLa Cells; Humans; Interphase; Polyamines; Putrescine; Spermidine; Spermine; Thymidine | 1986 |
The role of polyamine reutilization in depletion of cellular stores of polyamines in non-proliferating tissues.
Topics: Amino Acids; Animals; Brain; Eflornithine; Kidney; Liver; Male; Mice; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Spermidine | 1987 |
Sensitization of Chinese hamster ovary cells to heat shock by alpha-difluoromethylornithine.
Topics: Animals; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Eflornithine; Female; Hot Temperature; Kinetics; Ovary; Putrescine; Spermidine; Spermine | 1987 |
A Trypanosoma brucei mutant resistant to alpha-difluoromethylornithine.
Topics: Animals; Arginine; Drug Resistance; Eflornithine; Mutation; Ornithine; Ornithine Decarboxylase; Putrescine; Trypanosoma brucei brucei | 1987 |
Transient elevation of intrasynaptosomal free calcium by putrescine.
Topics: Animals; Brain; Calcium; Eflornithine; In Vitro Techniques; Male; Potassium; Putrescine; Rats; Spermidine; Spermine; Synaptosomes | 1987 |
Synergistic inhibition of polyamine synthesis and growth by difluoromethylornithine plus methylthioadenosine in methylthioadenosine phosphorylase-deficient murine lymphoma cells.
Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Drug Synergism; Eflornithine; Kinetics; Lymphoma; Mice; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; Spermidine; Spermine; Thionucleosides | 1987 |
Increased ornithine decarboxylase activity and polyamine biosynthesis are required for optimal cytolytic T lymphocyte induction.
Topics: Animals; Eflornithine; Interleukin-2; Lymphocyte Activation; Male; Mice; Ornithine Decarboxylase; Polyamines; Putrescine; T-Lymphocytes; T-Lymphocytes, Cytotoxic | 1987 |
Difluoromethylornithine enhances the uptake of methylglyoxal-bis(guanylhydrazone) prior to inhibiting leukemic cell proliferation.
Topics: Cell Division; Cells, Cultured; Eflornithine; Female; Humans; Leukemia; Mitoguazone; Ornithine Decarboxylase; Polyamines; Putrescine | 1987 |
Induction of ornithine decarboxylase activity and putrescine synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor.
Topics: Animals; Aorta; Cells, Cultured; DNA Replication; Eflornithine; Enzyme Induction; Kinetics; Male; Muscle, Smooth, Vascular; Ornithine Decarboxylase; Platelet-Derived Growth Factor; Polyamines; Putrescine; Rats; Rats, Inbred Strains | 1987 |
Diamine oxidase is important in assessment of polyamine effects on hemopoietic cell proliferation in vitro.
Topics: Amine Oxidase (Copper-Containing); Animals; Blood; Bone Marrow; Cell Division; Cell Line; Cells, Cultured; Culture Media; Eflornithine; Guanidines; Hematopoiesis; Hematopoietic Stem Cells; Humans; Mice; Putrescine | 1987 |
Human myeloma cells acquire resistance to difluoromethylornithine without overproducing ornithine decarboxylase.
Topics: Arginase; Cell Division; Cell Line; Drug Resistance; Eflornithine; Humans; Multiple Myeloma; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1987 |
Multiple pathways for uptake of paraquat, methylglyoxal bis(guanylhydrazone), and polyamines.
Topics: Aminoisobutyric Acids; Animals; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Eflornithine; Female; Mitoguazone; Ovary; Paraquat; Polyamines; Putrescine; Spermidine; Spermine | 1987 |
Effect of polyamine depletion on macromolecular synthesis of the malarial parasite, Plasmodium falciparum, cultured in human erythrocytes.
Topics: Eflornithine; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Macromolecular Substances; Nucleic Acids; Plasmodium falciparum; Polyamines; Protein Biosynthesis; Putrescine | 1987 |
Cytotoxic activity of a polyamine analogue, monoaziridinylputrescine, against the PC-3 human prostatic carcinoma cell line.
Topics: Cell Line; Cell Survival; Eflornithine; Humans; Kinetics; Male; Mathematics; Prostatic Neoplasms; Putrescine | 1987 |
The effect of alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, on mitogen-induced interleukin 2 production.
Topics: Animals; Concanavalin A; Eflornithine; In Vitro Techniques; Interleukin-2; Male; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; T-Lymphocytes | 1987 |
Permissive role for ornithine decarboxylase and putrescine in the luteinising hormone surge.
Topics: Animals; Eflornithine; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Kinetics; Luteinizing Hormone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pituitary Gland, Anterior; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1987 |
Inhibition of polyamine synthesis reduces the growth rate and delays the expression of differentiated phenotypes in primary cultures of embryonic mesoderm from chick.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Chick Embryo; Eflornithine; Hemoglobins; Kinetics; Mesoderm; Ornithine Decarboxylase Inhibitors; Phenotype; Polyamines; Proteoglycans; Putrescine; Sulfuric Acids; Tissue Plasminogen Activator | 1987 |
Enhanced antitumor efficacy with a combination of hyperthermochemotherapy and thermosensitization with polyamine antimetabolites in nude mice.
Topics: Animals; Antimetabolites, Antineoplastic; DNA, Neoplasm; Eflornithine; Hyperthermia, Induced; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Polyamines; Putrescine; Spermidine; Spermine; Stomach Neoplasms; Time Factors | 1987 |
An evaluation of the involvement of polyamines in modulating MCF-7 human breast cancer cell proliferation and progesterone receptor levels by estrogen and antiestrogen.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Neoplasms, Hormone-Dependent; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Receptors, Progesterone; Tamoxifen | 1987 |
Changes in the glutathione content of rat 9L cells induced by treatment with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine.
Topics: Alkylating Agents; Animals; Buthionine Sulfoximine; Carmustine; Eflornithine; Glutathione; Methionine Sulfoximine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Spermidine | 1987 |
Impairment of macrophage function by inhibitors of ornithine decarboxylase activity.
Topics: Animals; Cells, Cultured; Eflornithine; Macrophages; Mice; Mice, Inbred CBA; Microspheres; Myocardium; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phagocytosis; Putrescine; Trypanosoma cruzi | 1987 |
Inhibition of multiplication in Acanthamoeba castellanii by specific inhibitors of ornithine decarboxylase.
Topics: Acanthamoeba; Alkynes; Animals; Culture Media; Diamines; Eflornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine | 1987 |
Role of ornithine decarboxylase on glycolytic enzyme induction during thymocyte proliferation.
Topics: Animals; Cell Cycle; Cells, Cultured; Eflornithine; Enzyme Induction; Female; Glycolysis; Kinetics; Lymphocyte Activation; Microscopy, Electron; Ornithine Decarboxylase; Putrescine; Rats; Rats, Inbred Strains; T-Lymphocytes | 1987 |
Polyamines mediate uncontrolled calcium entry and cell damage in rat heart in the calcium paradox.
Topics: Animals; Calcium; Cytosol; Eflornithine; Female; Heart Diseases; Hypothermia, Induced; Microscopy, Electron; Myocardial Contraction; Myocardium; Myoglobin; Ornithine Decarboxylase; Perfusion; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1987 |
Additive growth-inhibitory effects of DL-alpha-difluoromethylornithine and antiestrogens on MCF-7 breast cancer cell line.
Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Eflornithine; Estrogen Antagonists; Growth Inhibitors; Humans; Putrescine; Tumor Cells, Cultured | 1987 |
Chain-fluorinated polyamines as tumor markers--I. In vivo transformation of 2,2-difluoroputrescine into 6,6-difluorospermidine and 6,6-difluorospermine.
Topics: Animals; Biomarkers, Tumor; Biotransformation; Cattle; Cell Division; Eflornithine; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Polyamines; Putrescine; Rats; Rats, Inbred BUF; Spermidine; Spermine | 1987 |
Mucosal polyamine profile in normal and adapting (hypo and hyperplastic) intestine: effects of DFMO treatment.
Topics: Adaptation, Physiological; Animals; Eflornithine; Hyperplasia; Intestinal Mucosa; Intestine, Small; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1987 |
Neurotoxicity of polyamines in rat cerebellar cultures.
Topics: Animals; Cells, Cultured; Cerebellum; DNA Replication; Eflornithine; Guanidines; Neurotoxins; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats | 1987 |
Regulation of ornithine decarboxylase mRNA translation by polyamines. Studies using a cell-free system and a cell line with an amplified ornithine decarboxylase gene.
Topics: Animals; Cell-Free System; Eflornithine; Gene Amplification; Leukemia L1210; Mice; Mutation; Ornithine Decarboxylase; Polyamines; Protein Biosynthesis; Putrescine; Rabbits; Reticulocytes; RNA, Messenger; Spermidine | 1988 |
Chain-fluorinated polyamines as tumor markers. II. Metabolic aspects in normal tissues.
Topics: Animals; Biomarkers, Tumor; Eflornithine; Fluorine; Half-Life; Mice; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine | 1988 |
Properties of L1210 cells resistant to alpha-difluoromethylornithine.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Deoxyadenosines; Drug Resistance; Eflornithine; Leukemia L1210; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured | 1988 |
Polyamine biosynthesis is necessary for interleukin-2-dependent proliferation but not for interleukin-2 production or high-affinity interleukin-2 receptor expression.
Topics: Animals; Cell Division; Concanavalin A; DNA; Eflornithine; Interleukin-2; Kinetics; Lymphocyte Activation; Lymphocytes; Male; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Interleukin-2; Spleen; T-Lymphocytes | 1987 |
Ornithine decarboxylase and polyamine levels in columnar upper gastrointestinal mucosae in patients with Barrett's esophagus.
Topics: Barrett Esophagus; Cell Division; Eflornithine; Epithelial Cells; Epithelium; Esophageal Diseases; Gastric Mucosa; Humans; Intestinal Mucosa; Intestine, Small; Male; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine | 1988 |
Dissociation of annulate lamellae in P3J, a Burkitt's lymphoma cell line.
Topics: Burkitt Lymphoma; Cell Line; Cytoplasmic Granules; Eflornithine; Humans; Microscopy, Electron; Putrescine | 1988 |
Treatment with polyamine synthesis inhibitors reduces the positive inotropic effect of ouabain, noradrenaline and calcium.
Topics: Animals; Calcium; Cardiotonic Agents; Eflornithine; Heart; Norepinephrine; Ouabain; Polyamines; Putrescine; Pyruvaldehyde; Rats; Spermidine; Spermine | 1988 |
Calmodulin antagonist inhibition of polyamine transport in prostatic cancer cells in vitro.
Topics: Animals; Bee Venoms; Biological Transport; Calmodulin; Eflornithine; Humans; Melitten; Putrescine; Rats; Tumor Cells, Cultured | 1988 |
Polyamine metabolism in reversible cerebral ischemia: effect of alpha-difluoromethylornithine.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Eflornithine; Female; Hippocampus; Ischemic Attack, Transient; Male; Ornithine Decarboxylase; Polyamines; Putrescine; Rats | 1988 |
Renal ornithine decarboxylase activity, polyamines, and compensatory renal hypertrophy in the rat.
Topics: Animals; Eflornithine; Hypertrophy; Kidney; Kinetics; Male; Nephrectomy; Ornithine Decarboxylase; Putrescine; Rats; Rats, Inbred Strains; Reference Values; Spermidine; Spermine | 1988 |
Characterization of a polyamine transport system in murine embryonic palate mesenchymal cells.
Topics: Animals; Eflornithine; Female; Kinetics; Male; Mice; Mice, Inbred C57BL; Palate; Polyamines; Putrescine; Sodium; Sulfhydryl Reagents | 1988 |
Polyamine depletion and growth inhibition in Candida albicans and Candida tropicalis by alpha-difluoromethylornithine and cyclohexylamine.
Topics: Candida; Candida albicans; Cyclohexylamines; Dose-Response Relationship, Drug; Eflornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine | 1988 |
Polyamines and insulin production in isolated mouse pancreatic islets.
Topics: Adenosine Triphosphate; Alkynes; Animals; Cells, Cultured; Diamines; DNA; Eflornithine; Glucose; Insulin; Islets of Langerhans; Male; Mice; Mitoguazone; Oxygen Consumption; Polyamines; Protein Biosynthesis; Putrescine; RNA, Messenger | 1988 |
Role of polyamines in the growth of hormone-responsive experimental breast cancer in vivo.
Topics: Animals; Biogenic Polyamines; Body Weight; Dose-Response Relationship, Drug; Eflornithine; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Putrescine; Rats; Rats, Inbred Strains | 1988 |
Role of polyamines in the stimulation of synthesis and secretion of plasminogen activator from bovine aortic endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Eflornithine; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Glycoproteins; Mitoguazone; Plasminogen Activators; Plasminogen Inactivators; Polyamines; Putrescine; Spermidine; Spermine | 1988 |
Effect of DL-alpha-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium.
Topics: Adenosine; Animals; Cadaverine; Chromatography, High Pressure Liquid; Culture Media; Eflornithine; Ornithine Decarboxylase; Polarography; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine; Spermine; Trichomonas vaginalis | 1988 |
Resumption of cell cycle in BALB/c-3T3 fibroblasts arrested by polyamine depletion: relation with "competence" gene expression.
Topics: Animals; Blood; Cell Cycle; Clone Cells; Culture Media; Eflornithine; Epidermal Growth Factor; Gene Expression Regulation; Insulin; Interphase; Mice; Ornithine Decarboxylase; Polyamines; Proto-Oncogenes; Putrescine | 1988 |
Inhibition of ornithine decarboxylase by retinoic acid and difluoromethylornithine in relation to their effects on differentiation and proliferation.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Eflornithine; Fibroblasts; Kinetics; Mice; Mice, Inbred BALB C; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Teratoma; Tretinoin | 1985 |
Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone).
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Eflornithine; Guanidines; Kinetics; Mitochondria; Mitoguazone; Ornithine; Putrescine; Pyruvates; Pyruvic Acid; Rats; Spermidine; Temperature; Time Factors | 1985 |
Inhibition of carcinogenesis by alpha-difluoromethylornithine in heterotopically transplanted rat urinary bladders.
Topics: Animals; Eflornithine; Male; Methylnitrosourea; Ornithine; Putrescine; Rats; Rats, Inbred F344; Spermidine; Spermine; Urinary Bladder; Urinary Bladder Neoplasms | 1985 |
Enhancement of the antiproliferative activity of human interferon by polyamine depletion.
Topics: Aspirin; Cell Division; Cell Line; Doxorubicin; Drug Synergism; Eflornithine; Humans; Indomethacin; Interferon Type I; Neoplasms; Ornithine; Polyamines; Putrescine; Tumor Stem Cell Assay | 1985 |
Effect of concentration of D,L-2-difluoromethylornithine on murine mammary carcinogenesis.
Topics: Animals; Antineoplastic Agents; Eflornithine; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Ornithine; Putrescine; Rats; Rats, Inbred Strains | 1985 |
Accumulation of ornithine decarboxylase-antizyme complex in HMOA cells.
Topics: Animals; Cells, Cultured; Chemical Precipitation; Chromatography, Gel; Cycloheximide; Eflornithine; Liver Neoplasms, Experimental; Methods; Ornithine; Ornithine Decarboxylase Inhibitors; Proteins; Putrescine; Rats | 1985 |
Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis.
Topics: Animals; Eflornithine; Kinetics; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1985 |
Cytotoxic activity of aziridinyl putrescine enhanced by polyamine depletion with alpha-difluoromethylornithine.
Topics: Antineoplastic Agents; Cell Line; Eflornithine; Humans; Male; Ornithine; Polyamines; Prostatic Neoplasms; Putrescine | 1985 |
Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cycloheximide; Eflornithine; Half-Life; Immunosorbent Techniques; Kinetics; Liver; Male; Mitoguazone; Molecular Weight; Ornithine; Prostate; Putrescine; Rabbits; Radioimmunoassay; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1985 |
Ornithine decarboxylase of Plasmodium falciparum: a peak-function enzyme and its inhibition by chloroquine.
Topics: Animals; Chloroquine; Drug Interactions; Eflornithine; Hydrogen-Ion Concentration; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plasmodium falciparum; Putrescine; Spermidine | 1985 |
Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Cycle; Cell Survival; Cyclohexylamines; Eflornithine; Mitoguazone; Ornithine; Polyamines; Putrescine; Rats; Spermidine Synthase; Transferases | 1985 |
The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Drug Interactions; Eflornithine; Female; Humans; Interferon Type I; Interferon-gamma; Melanoma; Ornithine; Putrescine | 1985 |
Induction of F9 embryonal carcinoma cell differentiation by inhibition of polyamine synthesis.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Thin Layer; Eflornithine; Embryonal Carcinoma Stem Cells; Mice; Neoplastic Stem Cells; Ornithine; Ornithine Decarboxylase; Plasminogen Activators; Polyamines; Putrescine; Teratoma; Tretinoin | 1985 |
Effects of difluoromethylornithine on proliferation, polyamine content and plating efficiency of cultured human carcinoma cells.
Topics: Cell Division; Cell Line; Clone Cells; Eflornithine; Female; Humans; Kinetics; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1985 |
Reversal of alpha-difluoromethylornithine inhibition of caerulein-induced pancreatic growth by putrescine.
Topics: Animals; Body Weight; Ceruletide; DNA; DNA Replication; Eflornithine; Male; Organ Size; Ornithine; Ornithine Decarboxylase Inhibitors; Pancreas; Putrescine; Rats; Rats, Inbred Strains | 1985 |
Translational regulation of mammalian ornithine decarboxylase by polyamines.
Topics: Animals; Cell Line; Drug Resistance; Eflornithine; Mice; Multiple Myeloma; Ornithine; Ornithine Decarboxylase; Polyamines; Protein Biosynthesis; Putrescine; RNA, Messenger | 1985 |
Inhibition of ornithine decarboxylase activity and cell growth by diamines: a comparison between the effects of two homologs, 1,3-diaminopropane and 1,4-diaminobutane (putrescine).
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Diamines; Eflornithine; Flow Cytometry; Kinetics; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine | 1985 |
Ornithine decarboxylase activity in human endometrium and endometrial cancer cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Corpus Luteum; Cycloheximide; Dactinomycin; Eflornithine; Endometrium; Female; Follicular Phase; Humans; Molybdenum; Ornithine; Ornithine Decarboxylase; Progesterone; Putrescine; Time Factors; Uterine Neoplasms | 1985 |
Effect of estrogen and androgen administration on alpha-difluoromethylornithine-enhanced putrescine uptake by the rat prostate.
Topics: Animals; Diethylstilbestrol; Dihydrotestosterone; Eflornithine; Male; Ornithine; Polyamines; Prostate; Putrescine; Rats; Rats, Inbred Strains | 1985 |
The competitive inhibition of tissue transglutaminase by alpha-difluoromethylornithine.
Topics: Acyltransferases; Animals; Caseins; Eflornithine; Guinea Pigs; Kinetics; Liver; Ornithine; Putrescine; Transglutaminases | 1984 |
Methylglyoxal BIS (guanylhydrazone) and alpha-difluoromethylornithine-induced polyamine deprivation in psoriatic lesions.
Topics: Carboxy-Lyases; Dose-Response Relationship, Drug; Eflornithine; Guanidines; Humans; Injections, Intradermal; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Psoriasis; Putrescine; Skin; Spermidine; Spermine | 1982 |
Effect of polyamine antimetabolites on cultured human keratinocytes from normal and uninvolved psoriatic skin.
Topics: Antimetabolites; Cell Division; Cells, Cultured; DNA; Eflornithine; Guanidines; Humans; Keratins; Mitoguazone; Ornithine; Protein Biosynthesis; Psoriasis; Putrescine; Skin; Spermidine; Spermine | 1984 |
Polyamines and the development of isolated neurons in cell culture.
Topics: Alkynes; Animals; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Chick Embryo; Diamines; Eflornithine; Nerve Tissue Proteins; Neurons; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; RNA | 1984 |
Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Cardiomegaly; Eflornithine; Isoproterenol; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains | 1982 |
Regulation of hematopoiesis II: the role of polyamine inhibition on helper or suppressor influences of the thymus.
Topics: Animals; Bone Marrow Cells; Colony-Forming Units Assay; Eflornithine; Erythrocytes; Hematopoiesis; Male; Mice; Ornithine; Polyamines; Putrescine; Spleen; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thymus Gland | 1983 |
Polyamines are necessary for the survival of human small-cell lung carcinoma in culture.
Topics: Carcinoma, Small Cell; Cell Aggregation; Cell Division; Cell Survival; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms; Ornithine; Polyamines; Putrescine | 1981 |
Temperature-dependent and transformation-associated changes in polyamine metabolism in normal and Rous sarcoma virus-infected chick embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Eflornithine; Fibroblasts; Ornithine; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine; Temperature | 1981 |
Role of polyamines in the proliferation and steroidogenic activities of bovine adrenocortical cells in culture.
Topics: Adrenal Cortex; Animals; Carboxy-Lyases; Cattle; Cell Division; Cells, Cultured; Cosyntropin; Cyclic AMP; Eflornithine; Hydrocortisone; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1981 |
Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Eflornithine; Interphase; Lymphoma; Mice; Models, Biological; Ornithine; Ornithine Decarboxylase; Polyamines; Protein Kinases; Putrescine; Spermidine | 1983 |
Differential effect of alpha-difluoromethyl-ornithine on the proliferation of Balb 3T3 and chemically transformed 3T3 cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA Replication; Eflornithine; Interphase; Kinetics; Mice; Mice, Inbred BALB C; Ornithine; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; Putrescine; Transcription, Genetic | 1983 |
D,L-alpha-difluoromethylornithine inhibits human cytomegalovirus replication.
Topics: Cells, Cultured; Cytomegalovirus; DNA, Viral; Eflornithine; Humans; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Simplexvirus; Spermidine; Spermine; Viral Proteins; Virion; Virus Replication | 1984 |
Radiochemical determination of polyamines in poliovirus and human rhinovirus 14.
Topics: Eflornithine; HeLa Cells; Humans; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Poliovirus; Putrescine; Rhinovirus; Spermidine; Spermine | 1984 |
Inhibition of growth of Giardia lamblia by difluoromethylornithine, a specific inhibitor of polyamine biosynthesis.
Topics: Animals; Eflornithine; Entamoeba histolytica; Giardia; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Trichomonas vaginalis | 1984 |
Microinjection of purified ornithine decarboxylase into Xenopus oocytes selectively stimulates ribosomal RNA synthesis.
Topics: Animals; Carboxy-Lyases; Eflornithine; Female; Guanosine; Microinjections; Oocytes; Ornithine; Ornithine Decarboxylase; Ovum; Putrescine; RNA, Ribosomal; Xenopus laevis | 1983 |
Divergent effects of ornithine decarboxylase inhibition on murine erythropoietic precursor cell proliferation and differentiation.
Topics: Animals; Bone Marrow; Carboxy-Lyases; Cell Differentiation; Cell Division; Cells, Cultured; Eflornithine; Hematopoietic Stem Cells; Kinetics; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine | 1983 |
Tumor selective enhancement of radioactivity uptake in mice treated with alpha-difluoromethylornithine prior to administration of 14C-putrescine.
Topics: Animals; Brain; Carbon Radioisotopes; Eflornithine; Lung; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Ornithine; Putrescine; Tissue Distribution | 1983 |
Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; DNA, Neoplasm; Eflornithine; Molecular Conformation; Ornithine; Polyamines; Putrescine; Rats; Spermidine; Viscosity | 1983 |
Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Eflornithine; Fluorouracil; Humans; Kinetics; Ornithine; Putrescine; Spermidine | 1983 |
Inhibition of DNA and protein synthesis in UV-irradiated mouse skin by 2-difluoromethylornithine, methylglyoxal bis(guanylhydrazone), and their combination.
Topics: Animals; DNA Replication; Drug Interactions; Eflornithine; Female; Guanidines; Mice; Mitoguazone; Ornithine; Protein Biosynthesis; Putrescine; Skin; Spermidine; Ultraviolet Rays | 1983 |
Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.
Topics: Animals; Blood Cell Count; Blood Platelets; Bone Marrow; Carboxy-Lyases; Cytarabine; Eflornithine; Erythrocytes; Female; Leukocytes; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains | 1983 |
Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation.
Topics: Animals; Carboxy-Lyases; Cell Differentiation; Cell Line; Eflornithine; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine; Teratoma | 1983 |
Inhibition of rat embryonic development by the intrauterine administration of alpha-difluoromethylornithine.
Topics: Animals; Contraceptives, Postcoital; Contraceptives, Postcoital, Synthetic; Eflornithine; Embryo Implantation; Embryo, Mammalian; Female; Ornithine; Ornithine Decarboxylase Inhibitors; Pregnancy; Putrescine; Rats; Rats, Inbred Strains; Uterus | 1983 |
Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn
Topics: Aged; Cadaverine; Chromatography, High Pressure Liquid; Eflornithine; Female; Fluorescence; Humans; Male; Middle Aged; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1983 |
Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Cerebrovascular Circulation; Eflornithine; Female; Freezing; Kinetics; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains | 1983 |
Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Eflornithine; Guanidines; Male; Mitoguazone; Ornithine; Polyamines; Prostatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains; Spermidine | 1984 |
Role of polyamines in differentiation of 3T3-L1 fibroblasts into adipocytes.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Eflornithine; Fibroblasts; Mice; Ornithine; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
Effects of polyamine depletion on proliferation and differentiation of murine erythroleukemia cells.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Diazepam; Dimethyl Sulfoxide; Eflornithine; Kinetics; Leukemia, Experimental; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells.
Topics: Animals; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; Cycloheximide; Eflornithine; Liver Neoplasms, Experimental; Macromolecular Substances; Neoplasm Proteins; Ornithine; Polyribosomes; Putrescine; Rats; Spermidine; Spermine | 1984 |
Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites.
Topics: Animals; Cadaverine; Carcinoma, Ehrlich Tumor; Diamines; Eflornithine; Guanidines; Mice; Mitoguazone; Ornithine; Putrescine | 1984 |
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Humans; Leukemia, Myeloid, Acute; Ornithine; Putrescine; Spermidine; Spermine | 1984 |
Time dependence of the potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity caused by alpha-difluoromethylornithine-induced polyamine depletion in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line; Drug Synergism; Eflornithine; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Spermidine | 1984 |
Mode of interaction of ornithine decarboxylase with antizyme and alpha-difluoromethylornithine.
Topics: Animals; Eflornithine; Enzyme Inhibitors; Female; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Proteins; Putrescine; Rats | 1984 |
Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced cytotoxicity and DNA damage by alpha-difluoromethylornithine in L1210 leukemia cells.
Topics: Animals; Carmustine; Cell Survival; DNA, Neoplasm; Drug Synergism; Eflornithine; Kinetics; Leukemia L1210; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
Polyamines as mediators of estrogen action on the growth of experimental breast cancer in rats.
Topics: Animals; Cell Aggregation; Eflornithine; Estradiol; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1984 |
The mechanism of hepatoprotection by epsilon aminocaproic acid and putrescine.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Chemical and Drug Induced Liver Injury; Eflornithine; Galactosamine; Liver Diseases; Necrosis; Ornithine; Ornithine Decarboxylase Inhibitors; Protease Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Urokinase-Type Plasminogen Activator | 1984 |
Polyamine biosynthetic enzymes as targets in cancer chemotherapy.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Enzyme Inhibitors; Methionine; Mice; Ornithine; Putrescine; Spermidine; Spermine; Teratoma | 1984 |
Role of polyamine synthesis in the stimulation of hexose transport by epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate in cultured mouse fibroblasts.
Topics: Animals; Cells, Cultured; Deoxyglucose; Eflornithine; Epidermal Growth Factor; Fibroblasts; Hexoses; Mice; Ornithine; Polyamines; Putrescine; Tetradecanoylphorbol Acetate | 1984 |
Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase.
Topics: Animals; Animals, Newborn; Brain; Cyclohexylamines; Dose-Response Relationship, Drug; Eflornithine; Female; Heart; Male; Myocardium; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermidine Synthase; Spermine; Transferases | 1984 |
Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II).
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Cisplatin; Cricetinae; Drug Evaluation, Preclinical; Drug Interactions; Eflornithine; Humans; Kinetics; Ornithine; Pancreatic Neoplasms; Putrescine | 1984 |
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Kinetics; Lung; Male; Monocrotaline; Ornithine; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Polyamines; Putrescine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio; Spermidine; Spermine | 1984 |
Reversal of the growth inhibitory effect of alpha-difluoromethylornithine by putrescine but not by other divalent cations.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Diamines; Eflornithine; Kinetics; Magnesium; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Structure-Activity Relationship | 1984 |
Polyamines and pancreatic growth induced by caerulein.
Topics: Animals; Ceruletide; DNA; Eflornithine; Male; Organ Size; Ornithine; Pancreas; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1984 |
alpha-(Fluoromethyl)dehydroornithine and alpha-(fluoromethyl)dehydroputrescine analogues as irreversible inhibitors of ornithine decarboxylase.
Topics: Animals; Eflornithine; Indicators and Reagents; Isomerism; Kinetics; Liver; Magnetic Resonance Spectroscopy; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Structure-Activity Relationship | 1983 |
Irreversible inhibition of the early increase in ornithine decarboxylase activity following growth stimulation is required to block Ehrlich ascites tumor cell proliferation in culture.
Topics: Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Cell Division; Eflornithine; Kinetics; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1980 |
Polyamine depletion induces enhanced synthesis and accumulation of cadaverine in cultured Ehrlich ascites carcinoma cells.
Topics: Animals; Cadaverine; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Cells, Cultured; Diamines; Eflornithine; Female; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1980 |
Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation.
Topics: Animals; Brain Neoplasms; Cell Line; Cell Survival; Cells, Cultured; DNA; DNA, Neoplasm; Eflornithine; Guanidines; Mitoguazone; Ornithine; Polyamines; Putrescine; Radiation Tolerance; Rats; Spermidine; Spermine; X-Rays | 1980 |
Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Interphase; Ornithine; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1981 |
Ovarian function in the rat following irreversible inhibition of L-ornithine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Estrus; Female; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Ovary; Ovulation; Pregnancy; Putrescine; Rats; Spermidine; Spermine | 1980 |
Intracellular putrescine and spermidine deprivation induces increased uptake of the natural polyamines and methylglyoxal bis(guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Mitoguazone; Ornithine; Ornithine Decarboxylase; Putrescine; Spermidine | 1980 |
Polyamine deprivation-induced enhanced uptake of methylglyoxal bis(guanylhydrazone) by tumor cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Eflornithine; Female; Guanidines; Humans; Iodoacetates; Iodoacetic Acid; Leukemia, Lymphoid; Mice; Mitoguazone; Ornithine; Putrescine; Spermine | 1981 |
Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Cycle; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Eflornithine; Glioma; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats | 1981 |
Aminoguanidine reversal of the inhibitory effects of ornithine analogs on the in vitro clonogenic survival of the R3327AT prostate-derived tumor.
Topics: Amine Oxidase (Copper-Containing); Animals; Carboxy-Lyases; Cell Line; Eflornithine; Guanidines; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Prostatic Neoplasms; Putrescine; Rats | 1981 |
Polyamines are needed for the differentiation of 3T3-L1 fibroblasts into adipose cells.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1981 |
Decarboxylation of ornithine and lysine by ornithine decarboxylase from kidneys of testosterone treated mice.
Topics: Animals; Cadaverine; Carboxy-Lyases; Eflornithine; Kidney; Lysine; Male; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Testosterone | 1981 |
Effect of alpha-difluoromethylornithine on polyamine and DNA synthesis in regenerating rat liver: reversal of inhibition of DNA synthesis by putrescine.
Topics: Animals; DNA; Eflornithine; Liver; Liver Regeneration; Male; Ornithine; Polyamines; Putrescine; Rats | 1982 |
Decreased cytotoxicity of cis-diamminedichloroplatinum(II) by alpha-difluoromethylornithine depletion of polyamines in 9L rat brain tumor cells in vitro.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cisplatin; DNA; Eflornithine; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats | 1982 |
Formation and interconversion of putrescine and spermidine in mammalian cells.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Cell Line; Eflornithine; Enzyme Activation; Enzyme Repression; Liver; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1980 |
Effects of inhibitors of ornithine and S-adenosylmethionine decarboxylases on L6 myoblast proliferation.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cells, Cultured; Eflornithine; Mitoguazone; Muscles; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1982 |
Effect of epidermal polyamine depletion on the accumulation of methylglyoxal bis(guanylhydrazone) in mouse skin.
Topics: Animals; Eflornithine; Female; Guanidines; Mice; Mitoguazone; Ornithine; Polyamines; Putrescine; Skin; Skin Physiological Phenomena; Spermidine | 1982 |
Some properties of the polyamine deprivation-inducible uptake system for methylglyoxal bis(guanylhydrazone) in tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Iodoacetates; Iodoacetic Acid; Mice; Mitoguazone; Neoplasms, Experimental; Ornithine; Ouabain; Polyamines; Putrescine; Spermidine | 1981 |
Accumulation of decarboxylated S-adenosyl-L-methionine in mammalian cells as a consequence of the inhibition of putrescine biosynthesis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cells, Cultured; Eflornithine; Liver Neoplasms, Experimental; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prostate; Putrescine; Rats; Rats, Inbred Strains | 1982 |
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1982 |
An essential role for polyamine biosynthesis during human granulopoietic differentiation.
Topics: Bone Marrow; Cell Differentiation; Cells, Cultured; Culture Media; Eflornithine; Granulocytes; Humans; Macrophages; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine | 1982 |
Replacement of natural polyamines by cadaverine and its aminopropyl derivatives in Ehrlich ascites carcinoma cells.
Topics: Animals; Cadaverine; Carcinoma, Ehrlich Tumor; Cell Division; Diamines; DNA Replication; Eflornithine; Kinetics; Mice; Ornithine; Protein Biosynthesis; Putrescine; Structure-Activity Relationship; Transcription, Genetic | 1982 |
Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Animals, Newborn; Brain; Carboxy-Lyases; Eflornithine; Female; Heart; Kidney; Myocardium; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1982 |
Polyamine depletion influences drug-induced chromosomal damage.
Topics: Animals; Carmustine; Chromosomes; Cisplatin; DNA; Eflornithine; Nucleic Acid Conformation; Ornithine; Polyamines; Putrescine; Rats; Sister Chromatid Exchange; Spermidine; Spermine | 1982 |
Difluoromethylornithine enhancement of putrescine uptake into the prostate: concise communication.
Topics: Animals; Castration; Eflornithine; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Prostate; Putrescine; Rats; Rats, Inbred Strains; Rats, Inbred WF | 1982 |
Delayed sensitization to heat by inhibitors of polyamine-biosynthetic enzymes.
Topics: Animals; Carboxy-Lyases; Cell Division; Cell Line; Cell Survival; Cricetinae; Cricetulus; Eflornithine; Female; Guanidines; Hot Temperature; Kinetics; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Ovary; Putrescine | 1982 |
alpha-Difluoromethylornithine: a promising lead for preventive chemotherapy for coccidiosis.
Topics: Animals; Cecal Diseases; Chickens; Coccidiosis; Coccidiostats; Eflornithine; Eimeria; Male; Ornithine; Poultry Diseases; Putrescine | 1982 |
Polyamines prevent DFMO-mediated inhibition of angiogenesis.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Eflornithine; Female; Lymphocytes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Polyamines; Putrescine; Spleen | 1994 |
Polyamine deficiency causes reorganization of F-actin and tropomyosin in IEC-6 cells.
Topics: Actins; Animals; Blotting, Northern; Blotting, Western; Cell Line; Cell Movement; Eflornithine; Isoenzymes; Polyamines; Putrescine; Rats; RNA, Messenger; Staining and Labeling; Tissue Distribution; Tropomyosin | 1994 |
Polyamines inhibit nitric oxide synthase in rat cerebellum.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cells, Cultured; Cerebellum; Citrulline; Cytosol; Eflornithine; Kinetics; N-Methylaspartate; Neurons; Nitric Oxide Synthase; omega-N-Methylarginine; Polyamines; Putrescine; Rats; Spermidine; Spermine; Tritium | 1994 |
Polyamine depletion-mediated effects on murine odontogenesis are dependent on tooth developmental stage and culture conditions.
Topics: Animals; Cell Differentiation; Cell Division; Culture Media; DNA; Eflornithine; Guanidines; Mice; Mitoguazone; Odontoblasts; Odontogenesis; Organ Culture Techniques; Polyamines; Putrescine; Spermidine; Time Factors; Tooth | 1995 |
The role of polyamine metabolism in dimorphism of Yarrowia lipolytica.
Topics: Azacitidine; DNA, Fungal; Eflornithine; Methylation; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Saccharomycetales | 1993 |
Depletion of cellular polyamines by alpha-difluoromethylornithine increases 1,3-bis(2-chloroethyl)-1-nitrosourea-induced sister-chromatid exchanges.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; Eflornithine; Nucleic Acid Conformation; Polyamines; Putrescine; Rats; Sister Chromatid Exchange; Spermidine | 1993 |
Polyamine metabolism in human hepatocellular cancer cells (Hep-G2).
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Eflornithine; Humans; Liver Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1994 |
Enzymatic aminopropylation of certain secondary amines.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Eflornithine; Gas Chromatography-Mass Spectrometry; Piperidines; Polyamines; Putrescine; Rats; Tumor Cells, Cultured | 1995 |
Arginine and ornithine metabolizing enzymes in testosterone-induced hypertrophic mouse kidney.
Topics: Animals; Arginase; Arginine; Eflornithine; Enzyme Induction; Female; Folic Acid; Hypertrophy; Kidney; Male; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Ornithine-Oxo-Acid Transaminase; Putrescine; Quinazolines; Sex Factors; Testosterone | 1995 |
Fluorinated analogues of L-ornithine are powerful inhibitors of ornithine decarboxylase and cell growth of Leishmania infantum promastigotes.
Topics: Animals; Anthelmintics; Cell Division; Dose-Response Relationship, Drug; Eflornithine; Kinetics; Leishmania infantum; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine | 1995 |
Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells.
Topics: Biological Transport; Breast Neoplasms; Cell Division; Cell Line; Cycloheximide; Drug Synergism; Eflornithine; Estradiol; Feedback; Humans; Insulin; Kinetics; Putrescine; Spermidine; Spermine; Tretinoin; Tumor Cells, Cultured | 1995 |
Aminooxy analogues of spermidine evidence the divergent roles of the charged amino nitrogens in the cellular physiology of spermidine.
Topics: Animals; Biogenic Polyamines; Biological Transport; Cell Division; Cells, Cultured; Cricetinae; Eflornithine; Embryo, Mammalian; Kidney; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine; Structure-Activity Relationship | 1995 |
Effects of metal treatment on DNA repair in polyamine-depleted HeLa cells with special reference to nickel.
Topics: DNA Repair; Eflornithine; HeLa Cells; Humans; Metals; Nickel; Putrescine; Spermidine; Spermine | 1994 |
Regulation of putrescine uptake in Leishmania mexicana promastigotes.
Topics: Animals; Biological Transport, Active; Cycloheximide; Eflornithine; Feedback; Kinetics; Leishmania mexicana; Polyamines; Putrescine | 1994 |
An inhibitor of polyamine biosynthesis impairs human polymorphonuclear leukocyte priming by tumor necrosis factor alpha.
Topics: Cell Adhesion; Cytoplasmic Granules; Eflornithine; Humans; Interleukin-1; Intracellular Fluid; Neutrophils; Ornithine Decarboxylase Inhibitors; Oxidation-Reduction; Putrescine; Receptors, Tumor Necrosis Factor; Respiratory Burst; RNA, Messenger; Secretory Rate; Spermine; Tumor Necrosis Factor-alpha; Up-Regulation | 1995 |
Phenotypic features of breast cancer cells overexpressing ornithine-decarboxylase.
Topics: Breast Neoplasms; Clone Cells; Eflornithine; Ornithine Decarboxylase; Phenotype; Polyamines; Putrescine; Receptors, Estrogen; Receptors, Progesterone; Transfection; Tumor Cells, Cultured | 1995 |
Induction of low-affinity GABAA receptors by the GABA-agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) in cultured rat cerebellar granule cells is prevented by inhibition of polyamine biosynthesis.
Topics: Animals; Biogenic Polyamines; Cells, Cultured; Cerebellum; Eflornithine; GABA Agonists; Isoxazoles; Kinetics; Membranes; Neurons; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Receptors, GABA-A; Spermidine | 1994 |
Regulation of N-methyl-D-aspartate receptor-mediated calcium transport and norepinephrine release in rat hippocampus synaptosomes by polyamines.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biological Transport; Calcium; Eflornithine; Egtazic Acid; Female; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Synaptosomes | 1994 |
Altered intracellular polyamines in bloodstream form Trypanosoma brucei brucei: transformation to procyclic trypomastigotes.
Topics: Aconitic Acid; Animals; Blood; Cell Division; Citrates; Citric Acid Cycle; Eflornithine; Polyamines; Putrescine; Trypanosoma brucei brucei | 1993 |
Regulation of transglutaminase activity by polyamines in the gastrointestinal mucosa of rats.
Topics: Animals; Chromatography, High Pressure Liquid; Duodenum; Eflornithine; Gastric Mucosa; Intestinal Mucosa; Kinetics; Male; Ornithine Decarboxylase; Parietal Cells, Gastric; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Spermidine; Spermine; Time Factors; Transglutaminases | 1994 |
Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cell Survival; Eflornithine; Gerbillinae; Male; Neurons; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; RNA, Messenger | 1994 |
Polyamines influence transglutaminase activity and cell migration in two cell lines.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Line; Cell Movement; Eflornithine; Humans; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Transglutaminases | 1994 |
Effects of the S-adenosylmethionine decarboxylase inhibitor, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Cell Division; CHO Cells; Cricetinae; Cycloheximide; Deoxyadenosines; Eflornithine; Kinetics; Polyamines; Putrescine; Spermidine; Spermine | 1994 |
Polyamines regulate human medullary thyroid carcinoma TT-cell proliferation and secretion of calcitonin and calcitonin gene-related peptide.
Topics: Adenosylmethionine Decarboxylase; Calcitonin; Calcitonin Gene-Related Peptide; Carcinoma, Medullary; Cell Division; Eflornithine; Humans; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Thyroid Neoplasms; Tumor Cells, Cultured | 1994 |
Polyamine regulation of atrial natriuretic peptide in cultured cardiocytes.
Topics: Animals; Atrial Natriuretic Factor; Cells, Cultured; Eflornithine; L-Lactate Dehydrogenase; Leucine; Myocardium; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Putrescine; Rats; Spermidine | 1994 |
Postnatal development of ornithine decarboxylase and polyamines in the mouse kidney: influence of testosterone.
Topics: Animals; Eflornithine; Female; Flutamide; Kidney; Male; Mice; Organ Size; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Sex Characteristics; Spermidine; Testosterone | 1994 |
Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Female; Flow Cytometry; G1 Phase; Gene Expression; Humans; Kinetics; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger; Spermidine; Spermine; Structure-Activity Relationship; Thymidine; Time Factors; Tumor Cells, Cultured | 1994 |
Polyamines mediate coronary transcapillary macromolecular transport in the calcium paradox.
Topics: Animals; Biological Transport; Calcium; Capillary Permeability; Cell Death; Coronary Vessels; Eflornithine; Female; Fluorescein; Fluoresceins; Horseradish Peroxidase; Muscle Proteins; Myocardium; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Perfusion; Putrescine; Rats; Rats, Sprague-Dawley | 1994 |
Polyamine content and drug sensitivities of different clonal lines of Leishmania infantum promastigotes.
Topics: Animals; Diminazene; Drug Resistance; Eflornithine; Leishmania infantum; Polyamines; Putrescine; Spermidine | 1994 |
Characterization of polyamine transport in rat aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Eflornithine; Kinetics; Muscle, Smooth, Vascular; Paraquat; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Spermidine; Spermine | 1994 |
alpha-Difluoromethylornithine decreases inhibitory transmission in hippocampal slices independently of its inhibitory effect on ornithine decarboxylase.
Topics: 2-Amino-5-phosphonovalerate; Animals; Depression, Chemical; Eflornithine; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1993 |
Ornithine decarboxylase inhibition or NMDA receptor antagonism reduce cortical polyamine efflux associated with dialysis probe implantation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biogenic Polyamines; Cerebral Cortex; Chromatography, High Pressure Liquid; Dialysis; Eflornithine; Male; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine | 1993 |
[The effect of chemically modified polyamine analogs on polyamine and putrescine biosynthesis in a cell-free test system from a rat hepatoma].
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Cell-Free System; Eflornithine; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine; Structure-Activity Relationship | 1993 |
Biosynthesis and selective export of 1,5-diaminopentane (cadaverine) in mycoplasma-free cultured mammalian cells.
Topics: Amino Acids; Animals; Biological Transport; Cadaverine; Carcinoma, Hepatocellular; Cell Line; Culture Media; Eflornithine; Insulin; Kinetics; Lipopolysaccharides; Lysine; Mice; Mycoplasma; Ornithine; Putrescine; Rats; Spectrometry, Mass, Fast Atom Bombardment; Tumor Cells, Cultured | 1994 |
Changing root system architecture through inhibition of putrescine and feruloyl putrescine accumulation.
Topics: Coumaric Acids; Eflornithine; Genes, Plant; Models, Biological; Nicotiana; Plants, Genetically Modified; Plants, Toxic; Putrescine; Rhizobium; Transformation, Genetic | 1994 |
Regulation of putrescine export in lipopolysaccharide or IFN-gamma-activated murine monocytic-leukemic RAW 264 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; DNA; Dose-Response Relationship, Drug; Eflornithine; Inflammation; Interferon-gamma; Leukemia, Myeloid; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Ornithine; Ornithine Decarboxylase; Putrescine; Tumor Cells, Cultured; Verapamil | 1994 |
Radiation brain injury is reduced by the polyamine inhibitor alpha-difluoromethylornithine.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain; Brain Edema; Capillary Permeability; Cerebrovascular Circulation; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Eflornithine; Iodine Radioisotopes; Male; Putrescine; Radiation Injuries, Experimental; Time Factors; Tomography, X-Ray Computed | 1994 |
Effects on tumor induction, growth, metastasis and histology of concurrent administration of putrescine and its metabolizing inhibitor alpha-difluoromethylornithine in nickel tumorigenesis in soft tissue.
Topics: Animals; Cell Differentiation; Eflornithine; Female; Neoplasms, Experimental; Nickel; Polyamines; Putrescine; Rats; Rats, Inbred F344; Sarcoma; Survival Analysis | 1994 |
Postnatal changes in cochlear polyamine metabolism in the rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cochlea; Eflornithine; Female; Organ of Corti; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Putrescine; Rats; Spermidine; Spermine | 1994 |
Endothelial polyamine uptake: selective stimulation by L-arginine deprivation or polyamine depletion.
Topics: Animals; Arginine; Biological Transport; Eflornithine; Endothelium, Vascular; Ornithine; Polyamines; Putrescine; Swine; Time Factors | 1994 |
Expression of protooncogenes c-fos and c-myc in healing of gastric mucosal stress ulcers.
Topics: Animals; Blotting, Northern; Blotting, Western; DNA; DNA Probes; Eflornithine; Enzyme Induction; Gastric Mucosa; Gene Expression; Genes, fos; Genes, myc; Immersion; Kinetics; Male; Ornithine Decarboxylase; Parietal Cells, Gastric; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Putrescine; Rats; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Spermidine; Spermine; Stomach Ulcer; Stress, Psychological; Thymidine; Time Factors; Wound Healing | 1994 |
Selenium and difluoromethylornithine additively inhibit DMH-induced distal colon tumor formation in rats fed a fiber-free diet.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Dimethylhydrazines; Drug Interactions; Eflornithine; Liver; Male; Ornithine Decarboxylase; Putrescine; Rats; Rats, Sprague-Dawley; Reference Values; S-Adenosylmethionine; Selenium; Spermidine; Spermine | 1993 |
Importance of various intracellular regulatory mechanisms of polyamine metabolism in camostate-induced pancreatic growth in rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Biogenic Polyamines; Eflornithine; Esters; Gabexate; Guanidines; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Pancreas; Putrescine; Rats; Rats, Wistar; Time Factors; Trypsin Inhibitors | 1993 |
Radiosensitivity of polyamine-depleted HeLa cells and modulation by the aminothiol WR-1065.
Topics: Cell Survival; Clone Cells; Deoxyadenosines; DNA Damage; Dose-Response Relationship, Radiation; Eflornithine; HeLa Cells; Humans; Kinetics; Mercaptoethylamines; Mitoguazone; Polyamines; Putrescine; Radiation-Protective Agents; Spermidine; Spermine; Time Factors; Tumor Stem Cell Assay; X-Rays | 1994 |
TGF-beta 1 inhibits polyamine biosynthesis in K 562 leukemic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosylmethionine Decarboxylase; Apoptosis; Cell Division; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Humans; Isoquinolines; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitoguazone; Ornithine Decarboxylase; Piperazines; Polyamines; Protein Kinase Inhibitors; Putrescine; Spermidine; Spermine; Transforming Growth Factor beta; Tumor Cells, Cultured | 1993 |
Polyamines in Trypanosoma cruzi.
Topics: Agmatine; Animals; Arginine; Carboxy-Lyases; Eflornithine; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protozoan Proteins; Putrescine; Trypanosoma cruzi | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Neoplasm; Eflornithine; Glucose; Glyburide; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Polyamines; Potassium; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Theophylline; Tolbutamide; Tumor Cells, Cultured | 1993 |
alpha-Difluoromethylornithine does not antagonize the behavioral effects of putrescine.
Topics: Animals; Behavior, Animal; Biogenic Polyamines; Brain Chemistry; Cerebral Cortex; Eflornithine; Exploratory Behavior; Male; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Sprague-Dawley | 1993 |
N-methyl-D-aspartate receptor excitotoxicity involves activation of polyamine synthesis: protection by alpha-difluoromethylornithine.
Topics: Animals; Calcium; Chick Embryo; Eflornithine; L-Lactate Dehydrogenase; N-Methylaspartate; Neurotoxins; Ornithine Decarboxylase; Polyamines; Putrescine; Receptors, N-Methyl-D-Aspartate; Retina | 1993 |
Polyamines and intestinal epithelial hyperplasia in streptozotocin-diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eflornithine; Epithelium; Hyperplasia; Intestinal Mucosa; Jejunum; Male; Organ Size; Ornithine Decarboxylase; Putrescine; Rats; Rats, Sprague-Dawley; Reference Values; Spermidine; Sucrase; Thymidine Kinase | 1993 |
Effect of difluoromethylornithine on atrial natriuretic peptide in rat atria.
Topics: Animals; Atrial Natriuretic Factor; Blotting, Western; Eflornithine; Heart Atria; Male; Methionine; Myocardium; Precipitin Tests; Putrescine; Rats; Rats, Sprague-Dawley | 1993 |
Polyamines are necessary for cell migration by a small intestinal crypt cell line.
Topics: Animals; Cell Line; Cell Movement; Eflornithine; Intestine, Small; Intracellular Membranes; Polyamines; Putrescine; Spermidine; Spermine | 1993 |
Effect of D,L-alpha-difluoromethylornithine (DFMO) enhanced [3H]putrescine uptake on 9L tumor cell growth and colony forming efficiency.
Topics: Animals; Biological Transport; Brain Neoplasms; Cell Division; Eflornithine; Glioma; Kinetics; Putrescine; Rats; Tritium; Tumor Cells, Cultured | 1993 |
Embryonic growth inhibition induced by cocaine is associated with the suppression of ornithine decarboxylase activity.
Topics: Animals; Cell Division; Chick Embryo; Cocaine; Dose-Response Relationship, Drug; Eflornithine; Insulin; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Thymidine; Time Factors | 1993 |
Effects of polyamine biosynthesis inhibitors on the progesterone-initiated increase in intracellular free Ca2+ and acrosome reactions in human sperm.
Topics: Acrosome; Adenosylmethionine Decarboxylase; Calcium; Deoxyadenosines; Eflornithine; Humans; In Vitro Techniques; Male; Polyamines; Progesterone; Putrescine; Spermatozoa; Spermidine | 1993 |
Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis.
Topics: Acetyltransferases; Blotting, Northern; Eflornithine; Gene Expression Regulation, Enzymologic; Homeostasis; Humans; Melanoma; Models, Biological; Polyamines; Putrescine; RNA, Messenger; Spermidine; Spermine; Tumor Cells, Cultured | 1993 |
Spermine action on mitochondrial H(+)-ATPase activity and proliferation rate of Trypanosoma cruzi.
Topics: Animals; Cycloheximide; Eflornithine; Kinetics; Mitochondria; Proton-Translocating ATPases; Putrescine; Spermidine; Spermine; Submitochondrial Particles; Trypanosoma cruzi | 1995 |
Stable intracellular acidification upon polyamine depletion induced by alpha-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells.
Topics: Animals; Antineoplastic Agents; Bicarbonates; Eflornithine; Hydrogen-Ion Concentration; Leukemia L1210; Mice; Nigericin; Polyamines; Putrescine; Sodium-Hydrogen Exchangers; Spermidine; Spermine | 1995 |
Spermine uptake is necessary to induce haemoglobin synthesis in murine erythroleukaemia cells.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carrier Proteins; Drug Resistance; Eflornithine; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Mutagenesis; Putrescine; Spermine; Transfection; Tumor Cells, Cultured | 1995 |
Regulation by spermine of native inward rectifier K+ channels in RBL-1 cells.
Topics: Animals; Deoxyadenosines; Eflornithine; Leukemia, Basophilic, Acute; Membrane Potentials; Ornithine Decarboxylase Inhibitors; Potassium Channels; Potassium Channels, Inwardly Rectifying; Putrescine; Rats; Spermidine; Spermine; Tumor Cells, Cultured | 1996 |
Impairment of DNA replication within one cell cycle after seeding of cells in the presence of a polyamine-biosynthesis inhibitor.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; CHO Cells; Cricetinae; DNA; DNA Replication; Eflornithine; Enzyme Inhibitors; Kinetics; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Putrescine; RNA; Spermidine; Spermine | 1996 |
First report of the inhibition of arbuscular mycorrhizal infection of Pisum sativum by specific and irreversible inhibition of polyamine biosynthesis or by gibberellic acid treatment.
Topics: Cadaverine; Eflornithine; Enzyme Inhibitors; Fungi; Gibberellins; Mutation; Ornithine Decarboxylase Inhibitors; Pisum sativum; Plant Diseases; Plant Growth Regulators; Plant Roots; Polyamines; Putrescine; Spermidine; Spermine | 1996 |
Role of endogenous polyamines in the proliferation of normal hematopoietic progenitor cells: high-proliferative potential colony-forming cells (HPP-CFC), and low-proliferative potential colony-forming cells (LPP-CFC). Studies "in vitro".
Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cells, Cultured; Eflornithine; Female; Hematopoietic Stem Cells; Mice; Mice, Inbred Strains; Polyamines; Putrescine | 1996 |
Effects of polyamine imbalance on the induction of stress genes in hepatocarcinoma cells exposed to heat shock.
Topics: Animals; Cell Division; Eflornithine; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Immediate-Early; Genes, jun; Heme Oxygenase (Decyclizing); Histones; HSP70 Heat-Shock Proteins; Humans; Kinetics; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Enhanced tissue polyamine content in the spontaneously hypertensive rat.
Topics: Animals; Blood Vessels; Cardiovascular System; Eflornithine; Enzyme Inhibitors; Heart Ventricles; Liver; Male; Polyamines; Putrescine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spermidine; Spermine | 1996 |
Putrescine active uptake system in the Trypanosomatid Crithidia fasciculata.
Topics: Animals; Arginine; Biological Transport, Active; Crithidia; Diamines; Down-Regulation; Eflornithine; Enzyme Inhibitors; Ethylmaleimide; Ionophores; Kinetics; Polyamines; Putrescine; Sulfhydryl Compounds; Trypanocidal Agents; Up-Regulation | 1996 |
Facile analysis of ribonucleotides in D,L-alpha-difluoromethylornithine-treated mouse lymphoid cells by high-performance anion-exchange column chromatography.
Topics: Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Eflornithine; Kinetics; Leukemia, Experimental; Lymphocytes; Mice; Putrescine; Ribonucleotides; Tumor Cells, Cultured | 1996 |
In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Eflornithine; Lung Neoplasms; Male; Metronidazole; Neomycin; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Prostatic Neoplasms; Protein Synthesis Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Survival Rate | 1996 |
Effects of gestational or neonatal treatment with alpha-difluoromethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry.
Topics: Animals; Animals, Newborn; Body Weight; Brain Chemistry; Cerebellum; Choline O-Acetyltransferase; Eflornithine; Female; Male; Organ Size; Ornithine Decarboxylase; Polyamines; Pregnancy; Prenatal Exposure Delayed Effects; Prosencephalon; Putrescine; Rats; Rats, Wistar; Spermidine | 1996 |
Putrescine modulation of depolarization-induced [3H]serotonin release from fish brain synaptosomes.
Topics: Animals; Brain; Brain Chemistry; Calcium; Eflornithine; Enzyme Inhibitors; Evoked Potentials; Fura-2; Membrane Potentials; Oncorhynchus mykiss; Phylogeny; Potassium Chloride; Putrescine; Serotonin; Signal Transduction; Synaptosomes; Tritium | 1996 |
Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine.
Topics: Animals; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Ornithine Decarboxylase Inhibitors; Pneumocystis; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1996 |
Polyamines as modulators of microcycle conidiation in Aspergillus flavus.
Topics: Aspergillus flavus; Cell Division; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Mitoguazone; Putrescine; Spermidine | 1996 |
Inward rectification of the large conductance potassium channel in smooth muscle cells from rabbit pulmonary artery.
Topics: Animals; Eflornithine; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Magnesium; Male; Muscle, Smooth, Vascular; Potassium Channels; Potassium Channels, Calcium-Activated; Pulmonary Artery; Putrescine; Rabbits | 1996 |
Dissimilar activation patterns of the carcinogen dimethylhydrazine (DMH) on intracellular polyamine metabolism in various organs.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Enzyme Activation; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine; Tissue Distribution | 1996 |
Growth arrest- and polyamine-dependent expression of spermidine/spermine N1-acetyltransferase in human tumor cells.
Topics: Acetyltransferases; Blotting, Northern; Cell Division; Colonic Neoplasms; Dactinomycin; Eflornithine; Enzyme Induction; Enzyme Repression; Heat-Shock Response; Humans; Polyamines; Putrescine; RNA; Spermidine; Spermine; Tumor Cells, Cultured | 1996 |
Uptake of extracellular, dietary putrescine is an important regulatory mechanism of intracellular polyamine metabolism during camostate-induced pancreatic growth in rats.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Eflornithine; Enzyme Inhibitors; Esters; Gabexate; Guanidines; Intestine, Small; Liver; Male; Ornithine Decarboxylase Inhibitors; Pancreas; Polyamines; Putrescine; Random Allocation; Rats; Time Factors; Tritium; Trypsin Inhibitors | 1997 |
Polyamines increase in the brain stem and cerebellum following labyrinthectomy.
Topics: Analysis of Variance; Animals; Brain Stem; Cerebellum; Chromatography, High Pressure Liquid; Ear, Inner; Eflornithine; Fluorometry; Functional Laterality; Guinea Pigs; Male; Polyamines; Putrescine; Spermidine; Time Factors | 1997 |
Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats.
Topics: Animals; Cells, Cultured; Eflornithine; Enzyme Inhibitors; Intestine, Small; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; Putrescine; Rats; Rats, Sprague-Dawley; Sepsis | 1996 |
Difluoromethylornithine enhanced uptake of tritiated putrescine in 9L rat brain tumors.
Topics: Animals; Brain; Brain Neoplasms; Eflornithine; Glioma; Male; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Inbred F344 | 1997 |
The role of the polyamine inhibitor eflornithine in the neuropathogenesis of experimental murine African trypanosomiasis.
Topics: Animals; Brain; Brain Diseases; Diminazene; Eflornithine; Female; Mice; Mice, Inbred Strains; Polyamines; Putrescine; Trypanocidal Agents; Trypanosomiasis, African | 1997 |
Specific requirement of putrescine for the mitogenic action of juvenile hormone on adult insect neuroblasts.
Topics: Animals; Brain; Eflornithine; Enzyme Inhibitors; Female; Gryllidae; Juvenile Hormones; Mitogens; Mitosis; Neurons; Ornithine Decarboxylase Inhibitors; Putrescine | 1997 |
Polyamine deprivation prevents the development of tumour-induced immune suppression.
Topics: Animals; Carcinoma, Lewis Lung; Dinoprostone; Eflornithine; Enzyme Inhibitors; Immune Tolerance; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Organ Size; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Spleen; T-Lymphocytes | 1997 |
Polyamines are important for attachment of IEC-6 cells to extracellular matrix.
Topics: Animals; Cadaverine; Cell Adhesion; Cell Line; Cell Movement; Collagen; Drug Combinations; Eflornithine; Enzyme Inhibitors; Extracellular Matrix; Integrins; Intestinal Mucosa; Intestine, Small; Laminin; Ornithine Decarboxylase; Plastics; Polyamines; Proteoglycans; Putrescine; Rats; Spermidine; Spermine | 1997 |
Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to D,L-alpha-difluoromethylornithine.
Topics: Animals; Blotting, Northern; Drug Resistance; Eflornithine; Enzyme Inhibitors; Half-Life; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; RNA, Messenger; Trypanocidal Agents; Trypanosoma brucei rhodesiense | 1997 |
The role of polyamines in liver regeneration after hepatectomy with ischemic injury.
Topics: Animals; DNA; Eflornithine; Hepatectomy; Lipid Peroxidation; Liver Regeneration; Male; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Reperfusion Injury | 1997 |
Rapid induction of apoptosis by deregulated uptake of polyamine analogues.
Topics: Alkylation; Animals; Apoptosis; Cell Death; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Eflornithine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Putrescine; Spermidine; Spermine | 1997 |
Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis.
Topics: Animals; Apoptosis; Cell Division; Diamines; Eflornithine; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Lysine; Microscopy, Electron; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Peptide Initiation Factors; Polyamines; Protein Processing, Post-Translational; Putrescine; Rats; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Anti-IgM-induced growth inhibition and apoptosis are independent of ornithine decarboxylase in Ramos cells.
Topics: Apoptosis; Burkitt Lymphoma; Cell Division; Eflornithine; Humans; Immunoglobulin M; Kinetics; Models, Biological; Ornithine Decarboxylase; Proto-Oncogene Proteins c-myc; Putrescine; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Dimethylsilane polyamines: cytostatic compounds with potentials as anticancer drugs.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; CHO Cells; Cricetinae; DNA; Drug Screening Assays, Antitumor; Eflornithine; Enzyme Inhibitors; Leukemia L1210; Mice; Polyamines; Putrescine; Silanes; Spermidine | 1997 |
Polyamine metabolism of rat gastric mucosa after oral administration of hypertonic sodium chloride solution.
Topics: Acetyltransferases; Administration, Oral; Animals; DNA Replication; Eflornithine; Enzyme Inhibitors; Gastric Mucosa; Male; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Rats, Wistar; Saline Solution, Hypertonic | 1998 |
Polyamine depletion protects HL-60 cells from 2-deoxy-D-ribose-induced apoptosis.
Topics: Apoptosis; Deoxyribose; DNA Fragmentation; Eflornithine; Enzyme Inhibitors; HL-60 Cells; Humans; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1998 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Eflornithine; Enzyme Inhibitors; Liver Neoplasms, Experimental; Membrane Fluidity; Microscopy, Electron, Scanning; Neoplasm Invasiveness; Putrescine; Rats; Spermidine; Spermine; Tumor Cells, Cultured | 1998 |
Inhibition of ornithine decarboxylase by ifenprodil.
Topics: Biogenic Polyamines; Eflornithine; Enzyme Inhibitors; Escherichia coli; Excitatory Amino Acid Antagonists; Ornithine Decarboxylase Inhibitors; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate | 1998 |
Trypanosoma brucei brucei: characterization of an ODC null bloodstream form mutant and the action of alpha-difluoromethylornithine.
Topics: Animals; Culture Media; Drug Resistance; Eflornithine; Mice; Mice, Inbred BALB C; Mutation; Ornithine Decarboxylase; Putrescine; Trypanocidal Agents; Trypanosoma brucei brucei | 1998 |
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine | 1998 |
Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.
Topics: Amidines; Animals; Antineoplastic Agents; Apoptosis; Eflornithine; Enzyme Inhibitors; Fas Ligand Protein; Granulocyte-Macrophage Colony-Stimulating Factor; HeLa Cells; Humans; Indans; Membrane Glycoproteins; Mice; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; T-Lymphocytes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Thrombin stimulates vascular smooth muscle cell polyamine synthesis by inducing cationic amino acid transporter and ornithine decarboxylase gene expression.
Topics: Amino Acid Transport Systems, Basic; Animals; Aorta, Thoracic; Biological Transport; Carrier Proteins; Cell Division; Cells, Cultured; Eflornithine; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation; Male; Membrane Proteins; Muscle Proteins; Muscle, Smooth, Vascular; omega-N-Methylarginine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; RNA, Messenger; Thrombin | 1998 |
A polyamine pathway-mediated mitogenic mechanism in enterochromaffin-like cells of Mastomys.
Topics: Animals; Cell Division; Cells, Cultured; DNA; Eflornithine; Enterochromaffin-like Cells; Gastric Mucosa; Gastrins; Muridae; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine; Transforming Growth Factor alpha | 1998 |
Involvement of ornithine decarboxylase and polyamines in epidermal growth factor-induced recovery of gastric mucosa from gastric lesions provoked by stress.
Topics: Animals; Anti-Ulcer Agents; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Gastric Mucosa; Indomethacin; Male; Ornithine Decarboxylase; Putrescine; Rats; Rats, Wistar; RNA, Messenger; Salivary Glands; Spermine; Stomach Ulcer; Stress, Psychological; Wound Healing | 1998 |
Differential effect on polyamine metabolism in mitogen- and superantigen-activated human T-cells.
Topics: Eflornithine; Humans; Interleukin-2; Lymphocyte Activation; Mitogens; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Receptors, Interleukin-2; Spermidine; Superantigens; T-Lymphocytes | 1998 |
Polyamines and epidermal growth factor in the recovery of gastric mucosa from stress-induced gastric lesions.
Topics: Animals; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Gastric Mucosa; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Spermine; Stomach Ulcer; Stress, Physiological | 1998 |
Influence of epidermal growth factor/transforming growth factor alpha and polyamines on Caco-2 cell proliferation.
Topics: Caco-2 Cells; Cell Cycle; Cell Division; Eflornithine; Epidermal Growth Factor; Humans; Mitosis; Putrescine; Transforming Growth Factor alpha | 1998 |
Comparative effects of TGFbeta on proliferation of 7- and 14-day-old chick embryo fibroblasts and lack of involvement of the ODC/PA system in the TGFbeta signaling pathway.
Topics: Animals; Cell Cycle; Cell Division; Cells, Cultured; Chick Embryo; Eflornithine; Enzyme Induction; Fibroblasts; Kinetics; Ornithine Decarboxylase; Polyamines; Putrescine; RNA; RNA, Messenger; S Phase; Signal Transduction; Skin; Spermidine; Spermine; Time Factors; Transcription, Genetic; Transforming Growth Factor beta | 1999 |
Uptake of putrescine by Trypanosoma granulosum.
Topics: Animals; Cycloheximide; Eels; Eflornithine; Kinetics; Ornithine Decarboxylase; Putrescine; Trypanosoma | 1998 |
2-deoxy-d-ribose-induced apoptosis in HL-60 cells is associated with the cell cycle progression by spermidine.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Cycle; Deoxyribose; Eflornithine; Flow Cytometry; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Onium Compounds; Organophosphorus Compounds; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Putrescine; Spermidine; Spermine | 1999 |
Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis.
Topics: Animals; Apoptosis; Cattle; Cell Line; Culture Media; Eflornithine; Gene Expression Regulation; Genes, p53; Intestinal Mucosa; Kinetics; Polyamines; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Transcription, Genetic; Tumor Suppressor Protein p53 | 1999 |
Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Body Weight; Brain Neoplasms; Corpus Striatum; Deoxyadenosines; Eflornithine; Enzyme Inhibitors; Gliosarcoma; Infusions, Parenteral; Male; Oxidoreductases Acting on CH-NH Group Donors; Putrescine; Rats; Rats, Inbred F344; Spermidine; Tritium; Tumor Cells, Cultured | 1999 |
Difluoromethylornithine chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Disease Progression; DNA Replication; Ear; Eflornithine; Epidermis; Gene Expression Regulation; Genes, Viral; Keratin-14; Keratins; Mice; Mice, Transgenic; Neoplasm Proteins; Organ Specificity; Ornithine Decarboxylase Inhibitors; Papilloma; Papillomaviridae; Precancerous Conditions; Putrescine; Skin Diseases; Skin Neoplasms; Thorax; Transgenes | 1999 |
The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Eflornithine; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Lysosomes; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Proto-Oncogene Proteins c-bcl-2; Putrescine; Spermidine; Spermine | 1999 |
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Okadaic Acid; Pancreatic Neoplasms; Phosphoprotein Phosphatases; Phosphorylation; Polyamines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 2000 |
Putrescine does not support the migration and growth of IEC-6 cells.
Topics: Actins; Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line; Cell Movement; Drug Combinations; Eflornithine; Enzyme Inhibitors; Intestine, Small; Intracellular Membranes; Mitoguazone; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermine | 2000 |
Changes in gene expression in response to polyamine depletion indicates selective stabilization of mRNAs.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line; Cloning, Molecular; Down-Regulation; Eflornithine; Expressed Sequence Tags; Gene Expression Regulation; Half-Life; Kidney; Mice; Mice, Transgenic; Molecular Sequence Data; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; RNA Stability; RNA, Messenger; Spermidine; Up-Regulation | 2000 |
Polyamine depletion delays apoptosis of rat intestinal epithelial cells.
Topics: Animals; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Adhesion; Cell Line; DNA Fragmentation; Eflornithine; Intestinal Mucosa; Kinetics; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 2000 |
Expression of the TGF-beta receptor gene and sensitivity to growth inhibition following polyamine depletion.
Topics: Activin Receptors, Type I; Animals; Cell Division; Cell Line; Eflornithine; Enzyme Inhibitors; Gene Expression; Humans; Intestine, Small; Laminin; Protein Serine-Threonine Kinases; Putrescine; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Spermidine; Spermine; Transforming Growth Factor beta; Tretinoin | 2000 |
Effect of the polyamine oxidase inactivator MDL 72527 on N(1)-(n-octanesulfonyl)spermine toxicity.
Topics: Amine Oxidase (Copper-Containing); Animals; Caco-2 Cells; Calmodulin; Cell Cycle; Cell Death; Drug Synergism; Eflornithine; Guanidines; Humans; Molecular Structure; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Spermine; Sulfonamides; Trifluoperazine; Tumor Cells, Cultured | 2000 |
Sensitivity of trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase.
Topics: Animals; Crithidia fasciculata; Cycloheximide; Eflornithine; Kinetics; Leishmania mexicana; Ornithine Decarboxylase; Putrescine; Spermidine; Time Factors; Trypanosoma cruzi; Trypanosomatina | 2000 |
NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Line; Cycloheximide; DNA Fragmentation; Eflornithine; G1 Phase; Intestinal Mucosa; Kinetics; NF-kappa B; Nucleosomes; Polyamines; Putrescine; Rats; Spermidine; Spermine; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi.
Topics: Animals; Biogenic Polyamines; Cadaverine; Culture Media; Eflornithine; Glutathione; Methylhistidines; Ornithine Decarboxylase; Putrescine; Spermidine; Spermine; Sulfhydryl Compounds; Tritium; Trypanosoma; Trypanosoma cruzi | 2001 |
Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms.
Topics: Caco-2 Cells; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Eflornithine; Enzyme Inhibitors; Humans; Intestinal Mucosa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Putrescine; Spermine; Tumor Suppressor Protein p53 | 2001 |
Polyamines regulate gap junction communication in connexin 43-expressing cells.
Topics: Animals; Butadienes; Cell Communication; Cell Line; Cells, Cultured; Connexin 43; Crosses, Genetic; Eflornithine; Embryo, Mammalian; Enzyme Inhibitors; Gap Junctions; Humans; Keratinocytes; Mice; Mice, Knockout; Nitriles; Ornithine Decarboxylase; Putrescine; Recombinant Proteins; Skin; Skin Physiological Phenomena; Spermidine | 2001 |
Changes in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin-independent rooting model.
Topics: Biogenic Polyamines; Cyclohexylamines; Eflornithine; Guanidines; In Vitro Techniques; Indoleacetic Acids; Indoles; Models, Biological; Oleaceae; Peroxidase; Plant Roots; Putrescine; Spermidine; Trees | 2001 |
Effect of inhibitors of polyamine biosynthesis on gibberellin-induced internode growth in light-grown dwarf peas.
Topics: Arginine; Carboxy-Lyases; Cycloheximide; Dactinomycin; Eflornithine; Enzyme Inhibitors; Gibberellins; Pisum sativum; Plant Growth Regulators; Polyamines; Protein Synthesis Inhibitors; Putrescine; RNA, Plant; Spermidine | 1986 |
Kinetic studies on the control of the bean rust fungus (Uromyces phaseoli L.) by an inhibitor of polyamine biosynthesis.
Topics: Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Fabaceae; Fungi; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plant Diseases; Plant Leaves; Plants, Medicinal; Polyamines; Putrescine; Spermidine; Spores | 1986 |
Arginine decarboxylase as the source of putrescine for tobacco alkaloids.
Topics: Alkaloids; Arginine; Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Nicotiana; Nicotine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Putrescine; Pyrrolidines | 1986 |
In vivo inhibition of polyamine biosynthesis and growth in tobacco ovary tissues.
Topics: Adenosylmethionine Decarboxylase; Arginine; Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Mitoguazone; Nicotiana; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Polyamines; Putrescine; Spermidine; Spermine | 1985 |
Effect of polyamine biosynthetic inhibitors on alkaloids and organogenesis in tobacco callus cultures.
Topics: Arginine; Biomass; Carboxy-Lyases; Culture Techniques; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Nicotiana; Nicotine; Ornithine Decarboxylase Inhibitors; Plant Roots; Plants, Toxic; Polyamines; Putrescine; Spermidine; Spermidine Synthase | 1987 |
Polyamine levels as related to growth, differentiation and senescence in protoplast-derived cultures of Vigna aconitifolia and Avena sativa.
Topics: Arginine; Avena; Carboxy-Lyases; Cell Differentiation; Cell Division; Cells, Cultured; Cellular Senescence; Chlorophyll; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Fabaceae; Ornithine Decarboxylase Inhibitors; Plant Proteins; Plants, Medicinal; Polyamines; Protoplasts; Putrescine; Spermidine; Spermidine Synthase | 1985 |
Polyamines and the integrity of the plant body.
Topics: Arginine; Carboxy-Lyases; Eflornithine; Ornithine Decarboxylase; Plant Cells; Plant Physiological Phenomena; Plants; Polyamines; Putrescine; Spermidine; Spermine | 1985 |
The effects of some polyamine biosynthetic inhibitors on growth and morphology of phytopathogenic fungi.
Topics: Arginine; Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Mitosporic Fungi; Ornithine Decarboxylase Inhibitors; Plant Diseases; Polyamines; Putrescine; Rhizoctonia; Spermidine | 1985 |
Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors.
Topics: Amino Acids; Antineoplastic Agents; Biological Transport; Drug Interactions; Drug Screening Assays, Antitumor; Eflornithine; Humans; Lysine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Spermidine is essential for normal proliferation of trypanosomatid protozoa.
Topics: Animals; Crithidia fasciculata; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Ornithine Decarboxylase; Putrescine; Spermidine; Spermidine Synthase; Spermine; Trypanosoma cruzi | 2001 |
Activities of arginase I and II are limiting for endothelial cell proliferation.
Topics: Animals; Arginase; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Eflornithine; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Isoenzymes; Lac Operon; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Transfection | 2002 |
The effect of DFMO induced uptake of [3H] putrescine on human glioma cells.
Topics: Biological Transport; Brain Neoplasms; Cell Adhesion; Cell Division; Colony-Forming Units Assay; Eflornithine; Enzyme Inhibitors; Glioma; Humans; Ornithine Decarboxylase Inhibitors; Putrescine; Tritium; Tumor Cells, Cultured | 2001 |
Quantitation of polyamines in hypothalamus and pituitary of female and male developing rats.
Topics: Agmatine; Animals; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Female; Hypothalamus; Male; Pituitary Gland; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Sex Characteristics; Spermidine; Spermine; Time Factors | 2002 |
Polyamine-dependent migration of retinal pigment epithelial cells.
Topics: Adenosylmethionine Decarboxylase; Cell Line; Cell Movement; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Humans; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pigment Epithelium of Eye; Putrescine; Spermidine; Spermine | 2002 |
Transcript levels of the eukaryotic translation initiation factor 5A gene peak at early G(1) phase of the cell cycle in the dinoflagellate Crypthecodinium cohnii.
Topics: Animals; Blotting, Northern; Blotting, Southern; Cell Division; Dinoflagellida; Eflornithine; Enzyme Inhibitors; Eukaryotic Cells; Eukaryotic Initiation Factor-5; G1 Phase; Guanine; Molecular Sequence Data; Peptide Initiation Factors; Phylogeny; Polyamines; Putrescine; RNA, Messenger; Toxins, Biological; Trypanocidal Agents | 2002 |
Involvement of polyamines in root development at low temperature in the subantarctic cruciferous species Pringlea antiscorbutica.
Topics: Acclimatization; Agmatine; Antarctic Regions; Arginine; Brassicaceae; Carboxy-Lyases; Cold Temperature; Drug Interactions; Eflornithine; Germination; Glutarates; Mitoguazone; Ornithine Decarboxylase; Plant Roots; Plant Shoots; Polyamines; Putrescine; Seeds; Spermidine; Spermine | 2002 |
Polyamine uptake is necessary for a normal biochemical maturation of astrocytes in culture.
Topics: Animals; Astrocytes; Biogenic Polyamines; Cell Differentiation; Cell Division; Cells, Cultured; Cerebellum; DNA; Down-Regulation; Eflornithine; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Mice; Mitoguazone; Ornithine Decarboxylase; Putrescine; Spermidine; Spermine; Thymidine; Up-Regulation | 2002 |
Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion.
Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Coumarins; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fibroblasts; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligopeptides; Ornithine Decarboxylase Inhibitors; Phosphorylation; Polyamines; Putrescine; Signal Transduction | 2002 |
Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Biological Transport; Cell Cycle; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eflornithine; Enzyme Inhibitors; Humans; Indoles; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Tumor Cells, Cultured | 2003 |
Contribution of spermidine to stimulation by hepatocyte growth factor in repair after damage of rabbit gastric mucosal cells in primary culture.
Topics: Animals; Cells, Cultured; DNA Repair; Eflornithine; Enzyme Inhibitors; Epithelial Cells; Gastric Mucosa; Hepatocyte Growth Factor; Putrescine; Rabbits; Spermidine; Wound Healing | 2003 |
Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries.
Topics: Carboxy-Lyases; Eflornithine; Flowers; Fruit; Gibberellins; Mutation; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Reproduction; RNA, Plant; Solanum lycopersicum; Spermidine; Spermidine Synthase; Spermine; Triazoles | 2003 |
Polyamines in cultured rabbit corneal cells.
Topics: Animals; Biogenic Polyamines; Cell Division; Cells, Cultured; Corneal Stroma; Dose-Response Relationship, Drug; Eflornithine; Endothelium, Corneal; Enzyme Inhibitors; Epithelium, Corneal; Fibroblasts; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Rabbits; Spermidine; Spermine; Time Factors | 2003 |
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Topics: Administration, Oral; Alopecia; Animals; Benz(a)Anthracenes; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Eflornithine; Enzyme Inhibitors; Epidermis; Hair Follicle; Isoenzymes; Mice; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Kinase C; Protein Kinase C-epsilon; Putrescine; Recombinant Fusion Proteins; Skin Neoplasms; Skin Ulcer; Tetradecanoylphorbol Acetate | 2003 |
Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system.
Topics: Animals; Brain; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation; Immunity, Innate; Lipopolysaccharides; Male; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Microglia; Mifepristone; Models, Biological; Neurons; Ornithine Decarboxylase; Polyamines; Putrescine; Receptors, Cell Surface; Spermine; Toll-Like Receptor 2; Toll-Like Receptors; Transcription, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2003 |
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosylmethionine Decarboxylase; Carcinoma; Cell Division; Deoxyadenosines; Eflornithine; Enzyme Inhibitors; Humans; Male; Methionine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Prostatic Neoplasms; Putrescine; RNA, Messenger; S-Adenosylmethionine; Tetracyclines; Thionucleosides; Tumor Cells, Cultured | 2004 |
Polyamines regulate eukaryotic initiation factor 4E-binding protein 1 gene transcription.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Base Sequence; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleus; DNA, Complementary; Eflornithine; Eukaryotic Initiation Factors; Genes, Reporter; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; NIH 3T3 Cells; Ornithine Decarboxylase; Phosphoproteins; Polyamines; Polymerase Chain Reaction; Putrescine; Rats; Response Elements; Ribonucleases; RNA, Messenger; Time Factors; Transcription, Genetic | 2004 |
Independent roles of eIF5A and polyamines in cell proliferation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cyclohexylamines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Half-Life; Humans; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Putrescine; Rats; RNA-Binding Proteins; Spermine | 2005 |
Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carcinoma 256, Walker; Cell Line, Tumor; Cell Nucleus; Eflornithine; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Experimental; Mice; Neoplasm Proteins; Neoplasm Transplantation; NF-kappa B; NF-kappa B p50 Subunit; Polyamines; Putrescine; Rats; Spermidine; Spermine; Surface Plasmon Resonance; Transcription Factor RelA; Transcriptional Activation | 2004 |
Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
Topics: Breast Neoplasms; Eflornithine; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Ornithine Decarboxylase Inhibitors; Osteopontin; Peptide Fragments; Phosphorylation; Putrescine; Sialoglycoproteins; Thrombospondin 1; Tumor Cells, Cultured | 2004 |
Depletion of polyamines and increase of transforming growth factor-beta1, c-myc, collagen-type I, matrix metalloproteinase-1, and metalloproteinase-2 mRNA in primary human gingival fibroblasts.
Topics: Adult; Cell Count; Cell Proliferation; Cells, Cultured; Collagen Type I; Eflornithine; Enzyme Inhibitors; Extracellular Matrix; Female; Fibroblasts; Gingiva; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Proto-Oncogene Proteins c-myc; Putrescine; RNA, Messenger; Spermidine; Spermine; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2005 |
Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells.
Topics: Animals; Antigens, CD34; Apoptosis; Blotting, Western; Bone Marrow Cells; Caspase 3; Caspases; Cell Adhesion; Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Separation; Coloring Agents; Eflornithine; Femur; Flow Cytometry; In Situ Nick-End Labeling; Leukocyte Common Antigens; Leupeptins; Microscopy, Fluorescence; Ornithine Decarboxylase; Osteocytes; Polyamines; Proteasome Inhibitors; Putrescine; Rats; Rats, Wistar; Spermidine; Stromal Cells; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2005 |
Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
Topics: Breast Neoplasms; Butadienes; Calcium-Binding Proteins; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Drug Interactions; Eflornithine; Flavonoids; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neoplasms, Hormone-Dependent; Nitriles; Phosphorylation; Putrescine; Retinoblastoma Protein | 2005 |
Induction of apoptotic cell death by putrescine.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Differentiation; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Eflornithine; Enzyme Inhibitors; G1 Phase; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine | 2006 |
Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene.
Topics: 5' Flanking Region; Acetyltransferases; Adaptor Proteins, Signal Transducing; Animals; Biogenic Polyamines; Carrier Proteins; Cell Cycle Proteins; Cell Nucleus; Cytosol; DNA Primers; Eflornithine; Electrophoretic Mobility Shift Assay; Eukaryotic Initiation Factors; Immunoblotting; Mice; NF-E2-Related Factor 2; NIH 3T3 Cells; Nuclear Proteins; Phosphoproteins; Putrescine; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2006 |
Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.
Topics: Amide Synthases; Animals; Culture Media; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutathione; Hematocrit; Hydrogen Peroxide; Male; NADH, NADPH Oxidoreductases; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Polyamines; Putrescine; Rats; Rats, Wistar; RNA, Messenger; Spermidine; Spermine; Trypanosoma brucei brucei; Trypanosomiasis, African | 2006 |
Polyamines, PI(4,5)P2, and actin polymerization.
Topics: Actins; Animals; Cells, Cultured; Cytoskeleton; Eflornithine; HL-60 Cells; Humans; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Polyamines; Putrescine; Rats; Spermidine; Spermine; Substrate Specificity; Time Factors | 2006 |
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Collagen; Drug Combinations; Eflornithine; Ki-67 Antigen; Laminin; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Polyamines; Proteoglycans; Putrescine; Spermidine; Spermine | 2007 |
Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Eflornithine; Humans; Kinetics; Neoplasms; Ornithine Decarboxylase; Polyamines; Putrescine | 2007 |
Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.
Topics: Animals; Cationic Amino Acid Transporter 1; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Enzyme Inhibitors; Epithelial Cells; Humans; Large Neutral Amino Acid-Transporter 1; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Proto-Oncogene Proteins c-myc; Putrescine; RNA Interference; RNA, Messenger; RNA, Small Interfering; Spermidine; Spermine; Swine; Telomerase; Time Factors; Transfection; Up-Regulation | 2007 |
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Survival; Cycloheximide; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibronectins; Integrin beta3; Intestinal Mucosa; MAP Kinase Kinase Kinases; Mice; Mutation; Oligopeptides; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphorylation; Polyamines; Protein Kinase Inhibitors; Putrescine; Pyrimidines; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2007 |
Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips.
Topics: Cycloheximide; Eflornithine; Enzyme Inhibitors; Meristem; Mitoguazone; Mitosis; Onions; Polyamines; Protein Synthesis Inhibitors; Putrescine; Spermidine; Spermine | 2008 |
Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol.
Topics: Citrus sinensis; Culture Media; DNA, Complementary; Eflornithine; Embryonic Development; Gene Expression Regulation, Plant; Glycerol; Morphogenesis; Plant Proteins; Polyamines; Putrescine; Seeds; Time Factors; Tissue Culture Techniques | 2009 |
Spermine-induced morphogenesis and effect of partial immersion system on the shoot cultures of banana.
Topics: Agriculture; Arginine; Eflornithine; Morphogenesis; Musa; Plant Shoots; Putrescine; Spermidine; Spermine | 2008 |
Role of putrescine on androgen-elicited positive inotropism in the left atrium of rats.
Topics: Adrenergic beta-Agonists; Androgens; Animals; Atrial Function; Cardiotonic Agents; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Dihydrotestosterone; Eflornithine; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine | 2008 |
Putrescine modulation of acute activation of the beta-adrenergic system in the left atrium of rat.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Cyclic AMP; Dihydroalprenolol; Eflornithine; Enzyme Inhibitors; Heart; Heart Atria; Isoproterenol; Male; Membranes; Myocardium; Putrescine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Spermidine; Spermine | 2008 |
Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Eflornithine; Enzyme Inhibitors; Exploratory Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Maze Learning; Memory; Memory Disorders; Motor Activity; Prefrontal Cortex; Putrescine; Rats; Rats, Sprague-Dawley; Space Perception; Spatial Behavior; Spermidine; Spermine | 2009 |
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Cell Proliferation; Cell Shape; Eflornithine; Fibroblasts; Gene Expression Regulation; Glucose Transporter Type 4; Isomerism; Lipid Metabolism; Mice; Organ Specificity; Putrescine; Spermidine; Time Factors | 2010 |
Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract.
Topics: Animals; Biological Transport; Catalysis; Caveolae; Caveolin 1; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Eflornithine; Endocytosis; Enzyme Inhibitors; Fusion Regulatory Protein 1, Heavy Chain; Gastrointestinal Tract; Humans; Mice; Mice, Knockout; Nitric Oxide Synthase; Putrescine; Spermidine | 2010 |
Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice.
Topics: Administration, Oral; Animals; Disease Models, Animal; Eflornithine; Enzyme Inhibitors; Female; Leishmania donovani; Leishmaniasis, Visceral; Macrophages; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Organisms, Genetically Modified; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phagosomes; Putrescine; Virulence; Water | 2011 |
Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines.
Topics: Animals; CELF1 Protein; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase 4; Eflornithine; Enzyme Assays; Epithelial Cells; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Intestinal Mucosa; Luciferases, Firefly; MicroRNAs; Open Reading Frames; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Binding; Protein Biosynthesis; Putrescine; Rats; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; Spermidine; Spermine; Transcription, Genetic | 2011 |
Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats.
Topics: Agmatine; Animals; Antineoplastic Agents; Behavior, Animal; Eflornithine; Enzyme Inhibitors; Hippocampus; Learning Disabilities; Male; Maze Learning; Memory; Memory Disorders; Organ Specificity; Ornithine Decarboxylase Inhibitors; Prefrontal Cortex; Putrescine; Random Allocation; Rats; Rats, Sprague-Dawley; Spatial Behavior; Spermidine; Toxicity Tests, Chronic | 2012 |
Reversal of difluoromethylornithine effects by the administration of putrescine in rats.
Topics: Animals; Antineoplastic Agents; Drug Interactions; Eflornithine; Female; Hypothyroidism; Putrescine; Radioimmunoassay; Rats; Thyroid Gland; Thyrotropin | 2011 |
An intercellular polyamine transfer via gap junctions regulates proliferation and response to stress in epithelial cells.
Topics: Actin Cytoskeleton; Animals; Biological Transport; Cell Communication; Cell Line; Cell Movement; Cell Proliferation; Coculture Techniques; Cyclohexylamines; Eflornithine; Epithelial Cells; Gap Junctions; Microtubules; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Polyamines; Putrescine; Rats; Spermine Synthase; Stress Fibers | 2013 |
Polyamine inhibitors for treatment of feline oral squamous cell carcinoma: a proof-of-concept study.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cat Diseases; Cats; Eflornithine; Evoked Potentials, Auditory, Brain Stem; Female; Hearing; Hearing Loss; Male; Mouth Mucosa; Mouth Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Thrombocytopenia | 2013 |
Inhibition of polyamine formation antagonizes vascular smooth muscle cell proliferation and preserves the contractile phenotype.
Topics: Animals; Cattle; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Eflornithine; Inhibitory Concentration 50; Male; Muscle Contraction; Muscle, Smooth, Vascular; Ornithine Decarboxylase; Phenotype; Putrescine; Rats; Rats, Sprague-Dawley; Spermidine; Spermine | 2014 |
Spermidine, a sensor for antizyme 1 expression regulates intracellular polyamine homeostasis.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Line; Eflornithine; Homeostasis; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proteins; Putrescine; Rats; Spermidine; Spermine | 2014 |
Putrescine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells.
Topics: Animals; Cell Proliferation; Cells, Cultured; Ectoderm; Eflornithine; Female; Pregnancy; Protein Biosynthesis; Putrescine; Signal Transduction; Swine; TOR Serine-Threonine Kinases; Trophoblasts; Up-Regulation | 2014 |
Suppression of ornithine decarboxylase promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Topics: Adipogenesis; Bone Marrow Cells; Bone Matrix; Calcification, Physiologic; Cell Proliferation; Cells, Cultured; Eflornithine; Gene Expression Regulation, Developmental; Humans; Kinetics; Lipid Metabolism; Mesenchymal Stem Cells; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Osteogenesis; Putrescine; RNA Interference; RNA, Small Interfering; Spermidine; Spermine | 2015 |
Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells.
Topics: Animals; Biogenic Polyamines; Biological Transport; Caveolin 1; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Eflornithine; Gene Expression Regulation; Humans; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Ornithine Decarboxylase Inhibitors; Phenotype; Polyamines; Putrescine; Spermidine; Time Factors; Tissue Culture Techniques; Vasoconstriction | 2016 |
Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.
Topics: Amine Oxidase (Copper-Containing); Cell Line, Tumor; Cell Proliferation; Eflornithine; Energy Metabolism; Female; Humans; Male; MCF-7 Cells; Molybdenum; Penicillamine; Polyamines; Putrescine; Reactive Oxygen Species; Spermine; Trientine | 2016 |
A Label-Free Continuous Fluorescence-Based Assay for Monitoring Ornithine Decarboxylase Activity with a Synthetic Putrescine Receptor.
Topics: Biological Assay; Cell Line; Eflornithine; Fluorescence; Fluorescent Dyes; HEK293 Cells; Humans; Kinetics; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Receptors, Artificial | 2017 |
Exploring polyamine metabolism of Alternaria alternata to target new substances to control the fungal infection.
Topics: Alternaria; Antifungal Agents; Biosynthetic Pathways; Culture Media; Eflornithine; Mycelium; Mycotoxins; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plant Diseases; Polyamines; Putrescine; Solanum lycopersicum | 2017 |
Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.
Topics: Animals; Brain; Cystathionine; Cystathionine beta-Synthase; Disease Models, Animal; DNA Methylation; Eflornithine; Humans; Mechanistic Target of Rapamycin Complex 1; Metabolomics; Methionine Adenosyltransferase; Mice; Neurons; Polyamines; Putrescine; S-Adenosylmethionine; Tuberous Sclerosis; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein | 2018 |
Extracellular Spermine Activates DNA Methyltransferase 3A and 3B.
Topics: Adenosylmethionine Decarboxylase; Cell Line, Tumor; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Modification Methylases; Eflornithine; Epithelial Cells; Humans; Jurkat Cells; Mammary Glands, Human; Ornithine Decarboxylase; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine; Spermine | 2019 |
Biochemical features of primary cells from a pediatric patient with a gain-of-function
Topics: Alopecia; Biopsy; Cells, Cultured; Child, Preschool; Dermis; Developmental Disabilities; Dicarboxylic Acid Transporters; Eflornithine; Female; Fibroblasts; Gain of Function Mutation; Humans; Mitochondrial Membrane Transport Proteins; Putrescine | 2019 |
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.
Topics: Acetyltransferases; Adenosine Triphosphate; Aerobiosis; Algorithms; Animals; Autoimmunity; Chromatin; Citric Acid Cycle; Cytokines; Eflornithine; Encephalomyelitis, Autoimmune, Experimental; Epigenome; Fatty Acids; Glycolysis; Jumonji Domain-Containing Histone Demethylases; Mice, Inbred C57BL; Mitochondrial Membrane Transport Proteins; Models, Biological; Oxidation-Reduction; Putrescine; Single-Cell Analysis; T-Lymphocytes, Regulatory; Th17 Cells; Transcriptome | 2021 |
Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease.
Topics: Alopecia; Child, Preschool; Dicarboxylic Acid Transporters; Drug Repositioning; Eflornithine; Exome Sequencing; Gain of Function Mutation; Genetic Variation; Humans; Mitochondrial Membrane Transport Proteins; Ornithine Decarboxylase; Polyamines; Putrescine; Rare Diseases | 2021 |
Hyperglycemic conditions proliferate triple negative breast cancer cells: role of ornithine decarboxylase.
Topics: Breast Neoplasms; Eflornithine; Female; Humans; Hyperglycemia; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Triple Negative Breast Neoplasms | 2021 |
Effects of Spermidine on Cell Proliferation, Migration, and Inflammatory Response in Porcine Enterocytes.
Topics: Animals; Cell Proliferation; Cytokines; Eflornithine; Enterocytes; Lipopolysaccharides; Putrescine; Spermidine; Swine; Tumor Necrosis Factor-alpha | 2022 |
Effects of putrescine on the quality and epigenetic modification of mouse oocytes during
Topics: Animals; Eflornithine; Epigenesis, Genetic; Female; Humans; In Vitro Oocyte Maturation Techniques; Infant; Luteinizing Hormone; Mice; Oocytes; Pregnancy; Putrescine; Reactive Oxygen Species; Sirtuin 1 | 2022 |
Elucidating the Role of
Topics: Animals; Drosophila melanogaster; Eflornithine; Polyamines; Putrescine; Spermidine; Spermine | 2022 |
Intracellular polyamine depletion induces N-linked galactosylation of the monoclonal antibody produced by CHO DP-12 cells.
Topics: Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; Cricetulus; Eflornithine; Glycoproteins; Immunoglobulin G; Polyamines; Polysaccharides; Putrescine; RNA, Messenger; Spermine; Tunicamycin | 2023 |