puromycin and danthron

puromycin has been researched along with danthron* in 1 studies

Other Studies

1 other study(ies) available for puromycin and danthron

ArticleYear
Albopunctatone, an antiplasmodial anthrone-anthraquinone from the Australian ascidian Didemnum albopunctatum.
    Journal of natural products, 2012, Jun-22, Volume: 75, Issue:6

    Chemical investigation of a MeOH extract of the Great Barrier Reef ascidian Didemnum albopunctatum has led to the isolation and identification of a new anthrone-anthraquinone, albopunctatone (1), together with the known 1,8-dihydroxy-9,10-anthraquinone (2). The structure of 1 was established from interpretation of 1D and 2D NMR spectroscopic and mass spectrometric data. The compounds were screened for antiplasmodial activity against chloroquine-resistant and -sensitive strains of the malaria parasite, Plasmodium falciparum. Albopunctatone (1) was moderately active against both strains (IC(50) 5.3 and 4.4 ± 0.5 μM, respectively), while 2 was inactive at doses up to 40 μM. Both compounds were also inactive up to 40 μM when tested against a variety of cancerous and normal human cell lines and the kinetoplastid Trypanosoma brucei brucei, indicating selectivity for the malaria parasite, P. falciparum.

    Topics: Animals; Anthraquinones; Antimalarials; Antineoplastic Agents; Australia; Chloroquine; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; Molecular Structure; Plasmodium falciparum; Trypanosoma brucei brucei; Urochordata

2012