purine and methotrexate

purine has been researched along with methotrexate in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (51.35)	18.7374
1990's	5 (13.51)	18.2507
2000's	5 (13.51)	29.6817
2010's	6 (16.22)	24.3611
2020's	2 (5.41)	2.80

Authors

Authors	Studies
Nakamura, T; Uchida, M; Ueda, T	1
Koizumi, S	1
Blank, JA; Germolec, DR; Luster, MI; Rosenthal, GJ; Weigand, GW	1
Bökkerink, JP; De Abreu, RA; De Bruyn, CH; De Vaan, GA; Lippens, RJ; Schouten, TJ; Van Laarhoven, JP	1
Evans, WE; Masson, E; Pui, CH; Relling, MV; Sandlund, JT; Schuetz, JD; Synold, TW	1
Carrera, CJ; Carson, DA; Hori, H; Hori, Y; Nobori, T; Rosenbach, MD; Tran, P	1
Chen, ZH; Olopade, OI; Savarese, TM	1
Chen, VJ; Gates, SB; Habeck, LL; Mendelsohn, LG; Shackelford, KA; Shih, C	1
DENNIS, D; GOLDIN, A; GREENHOUSE, SW; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM	1
GUTHRIE, R; HILLMAN, MJ; LOEBECK, ME; ZGORZYNSKI, F	1
DARROW, RA; GOLDIN, A; SHUSTER, L	1
ALEXANDRE, GP; DAMMIN, GJ; MURRAY, JE; NOLAN, B	1
HUTCHISON, DJ; JOHNSON, AH	1
WOODLIFF, HJ	1
ALBRECHT, AM; HUTCHISON, DJ	1
ANDERSON, EP; BROCKMAN, RW	1
BLUMENSTOCK, DA; COLLINS, JA; FERREBEE, JW; HECHTMAN, HB; HOSBEIN, DJ; THOMAS, ED	1
CUTTS, JH	1
SCHINKLER, R	1
NARKATES, AJ; PITTILLO, RF	1
ELLISON, LT; ELLISON, RG; YEH, TJ	1
ERASLAN, S; HARDY, JD; WEBB, WR	1
GOLDIN, A; LYNCH, MR; MEAD, JA; SCHRECKER, AW	1
Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA	1
Assaraf, YG; Ifergan, I; Kadry, WN; Pinter, RY	1
Beckers, A; Brusselmans, K; Deboel, L; Derua, R; Organe, S; Swinnen, JV; Timmermans, L; Vanderhoydonc, F; Verhoeven, G; Waelkens, E	1
Arenas, M; Barker, JN; Campalani, E; Lewis, CM; Marinaki, AM; Smith, CH	1
Aneja, R; Arya, V; Das, M; Dhir, V; Grover, R; Gupta, R; Juyal, RC; K, TB; Kumar, A; Kumar, U; Marwaha, V; Raghu, P; Shankar, S; Sharma, S; Singh, P	1
Dalhoff, K; Hedeland, RL; Hvidt, K; Lausen, B; Nersting, J; Rosthøj, S; Schmiegelow, K	1
Guo, R; Jiang, L; Li, J; Xu, D; Yu, L; Zhao, J	1
Benz, C; Cadman, E; Heimer, R; O'Shaughnessy, J	1
Bowman, WP; Boyett, JM; Cheng, C; Evans, WE; Mikkelsen, TS; Panetta, JC; Pui, CH; Raimondi, SC; Relling, MV; Sandlund, JT; Sparreboom, A; Zhou, Y	1
Bertino, JR; Boros, LG; Chan, LL; DiPaola, RS; Dolfi, SC; Dvorzhinski, D; Gounder, M; Hirshfield, KM; Lin, H; Markert, EK; Oltvai, ZN; Qiu, J; Tedeschi, PM; Vazquez, A	1
Audet-Walsh, É; Bourque, G; Bridon, G; Caron, M; Giguère, V; Gravel, SP; Papadopoli, DJ; St-Pierre, J; Yee, T	1
Sharara, AI	1
Chhibba, T; Ma, C	1
Alexander, M; Deshpande, I; Nayak, RR; Patterson, AD; Rimal, B; Scher, JU; Stapleton-Gray, K; Turnbaugh, PJ; Ubeda, C	1

Reviews

5 review(s) available for purine and methotrexate

Article	Year
[Clinical pharmacology of anticancer agents [Part 5] Antimetabolites (2)]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:3 Topics: Antimetabolites, Antineoplastic; Folic Acid Antagonists; Guanine Nucleotides; Humans; Methotrexate; Neoplasms; Purines	1992
Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6 Topics: Animals; Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Purines; Tetrahydrofolates	1999
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS). Annual review of biochemistry, 1963, Volume: 32 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil	1963
When to Start Immunomodulators in Inflammatory Bowel Disease? Digestive diseases (Basel, Switzerland), 2016, Volume: 34, Issue:1-2 Topics: Drug Therapy, Combination; Humans; Immunologic Factors; Inflammatory Bowel Diseases; Methotrexate; Purines; Tumor Necrosis Factor-alpha	2016
Is there room for immunomodulators in ulcerative colitis? Expert opinion on biological therapy, 2020, Volume: 20, Issue:4 Topics: Clinical Trials as Topic; Colitis, Ulcerative; Gastrointestinal Diseases; Humans; Immunologic Factors; Methotrexate; Purines; Severity of Illness Index; Treatment Outcome	2020

Trials

3 trial(s) available for purine and methotrexate

Article	Year
Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia. Leukemia, 1996, Volume: 10, Issue:1 Topics: Adolescent; Allopurinol; Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Humans; Infant; Linear Models; Lymphocytes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines	1996
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. Arthritis and rheumatism, 2004, Volume: 50, Issue:10 Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12	2004
Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, May-01, Volume: 29, Issue:13 Topics: Adolescent; Antimetabolites, Antineoplastic; Child, Preschool; Drug Administration Schedule; Humans; Infant; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines	2011

Other Studies

29 other study(ies) available for purine and methotrexate

Article	Year
Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines. Japanese journal of cancer research : Gann, 1988, Volume: 79, Issue:11 Topics: Drug Resistance; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methotrexate; Peptide Biosynthesis; Polyglutamic Acid; Purines; Tumor Cells, Cultured	1988
Suppression of B cell function by methotrexate and trimetrexate. Evidence for inhibition of purine biosynthesis as a major mechanism of action. Journal of immunology (Baltimore, Md. : 1950), 1988, Jul-15, Volume: 141, Issue:2 Topics: Animals; Antibody Formation; B-Lymphocytes; Cell Differentiation; Female; Folic Acid Antagonists; Immunoglobulins; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Methotrexate; Mice; Purines; Quinazolines; Trimetrexate	1988
[6-Mercaptopurine and methotrexate, rational use in sight after 35 years?]. Tijdschrift voor kindergeneeskunde, 1984, Volume: 52, Issue:4 Topics: Animals; Child; Dogs; Half-Life; Humans; Infusions, Parenteral; Leukemia, Lymphoid; Lymphocytes; Mercaptopurine; Methotrexate; Purines; Pyrimidines	1984
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells. Cancer research, 1996, Dec-15, Volume: 56, Issue:24 Topics: Alanine; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Feasibility Studies; Genetic Vectors; Humans; Lung Neoplasms; Methionine; Methotrexate; Neoplasm Proteins; Purine-Nucleoside Phosphorylase; Purines; Tetrahydrofolates; Transcription, Genetic; Transfection; Tumor Cells, Cultured	1996
Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis. Molecular pharmacology, 1997, Volume: 52, Issue:5 Topics: Adenosine; Antimalarials; Antimetabolites, Antineoplastic; Azaserine; Biomarkers, Tumor; Cell Count; Deoxyadenosines; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Methionine; Methotrexate; Pancreatic Neoplasms; Purine-Nucleoside Phosphorylase; Purines; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured	1997
An investigation into the synergistic antileukemic action of amethopterin and 6-mercaptopurine in mice. Journal of the National Cancer Institute, 1955, Volume: 16, Issue:1 Topics: Animals; Folic Acid Antagonists; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Purines	1955
Tests for collateral sensitivity or cross resistance in bacterial mutants resistant to amethopterin or purine analogs. Cancer research, 1958, Volume: 18, Issue:8 Part 2 Topics: Antimetabolites; Bacillus subtilis; Escherichia coli; Folic Acid Antagonists; Humans; Methotrexate; Purines	1958
Amethopterin and liver purine metabolism in vivo. Cancer research, 1960, Volume: 20 Topics: Folic Acid Antagonists; Liver; Metabolic Networks and Pathways; Methotrexate; Purines	1960
IMMUNOSUPPRESSIVE DRUG THERAPY IN CANINE RENAL AND SKIN HOMOGRAFTS. Transplantation, 1963, Volume: 1 Topics: Allergy and Immunology; Allografts; Animals; Azaserine; Dactinomycin; Dogs; Immunosuppressive Agents; Kidney Transplantation; Leukopenia; Methotrexate; Purines; Pyrazoles; Pyrimidines; Research; Skin Transplantation; Thrombocytopenia; Urea	1963
FOLIC ACID METABOLISM IN ANTIFOLIC-RESISTANT MUTANTS OF STREPTOCOCCUS FAECALIS. Journal of bacteriology, 1964, Volume: 87 Topics: Adenine; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Guanine; Metabolism; Methotrexate; Mutation; Purines; Research; Serine; Thymine; Xanthines	1964
IN-VITRO SENSITIVITY TESTS OF LEUKAEMIC CELLS TO CHEMOTHERAPEUTIC AGENTS. The Medical journal of Australia, 1964, Apr-04, Volume: 1 Topics: Aminopterin; Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Geriatrics; Histological Techniques; Hydrocortisone; Leukemia; Leukemia, Lymphoid; Leukocytosis; Mercaptopurine; Methotrexate; Mice; Polycythemia Vera; Purines; Research; Tissue Culture Techniques	1964
REPRESSION BY ADENINE OF THE FORMYLTETRAHYDROFOLATE SYNTHETASE IN AN ANTIFOLIC-RESISTANT MUTANT OF STREPTOCOCCUS FAECALIS. Journal of bacteriology, 1964, Volume: 87 Topics: Adenine; Bacteriological Techniques; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Formate-Tetrahydrofolate Ligase; Guanine; Ligases; Methotrexate; Mutation; Purines; Research; Tetrahydrofolate Dehydrogenase; Thymine	1964
LATE RESULTS OF HOMOTRANSPLANTATION OF THE LUNG IN DOGS. Diseases of the chest, 1964, Volume: 45 Topics: Antineoplastic Agents; Dogs; Lung; Methotrexate; Pharmacology; Purines; Radiation Effects; Research; Transplantation; Transplantation Immunology; Transplantation, Homologous	1964
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE. Biochemical pharmacology, 1964, Volume: 13 Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cortisone; Glutamates; Leukemia; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Pharmacology; Purines; Research; Tryptophan; Vinblastine	1964
[INFLUENCING THE CELL DIVISION CYCLE IN CELL CULTURES BY VARIATION OF THE CULTURE MEDIUM]. Helvetica physiologica et pharmacologica acta, 1964, Volume: 22 Topics: Cell Division; Culture Media; DNA; Glycine; Leucine; Methotrexate; Purines; Thymidine; Thymine; Tissue Culture Techniques	1964
FOLIC ACID INHIBITION OF NON-PROLIFERATING BACTERIA. Canadian journal of microbiology, 1964, Volume: 10 Topics: Bacillus cereus; Bacteria; Bacteriological Techniques; Candida; Culture Media; Escherichia coli; Folic Acid; Metabolism; Methotrexate; Pharmacology; Pseudomonas aeruginosa; Purines; Research; Saccharomyces; Salmonella typhimurium; Staphylococcus	1964
ALVEOLAR SURFACTANT IN LUNG HOMOTRANSPLANTATION AND HILAR STRIPPING. Surgical forum, 1964, Volume: 15 Topics: Azathioprine; Dogs; Lung; Methotrexate; Pharmacology; Purines; Research; Surface Tension; Surface-Active Agents; Transplantation Immunology; Transplantation, Homologous	1964
TRANSPLANTATION OF THE LUNG. Annals of surgery, 1964, Volume: 160 Topics: Animals; Bronchoscopy; Carcinoma, Squamous Cell; Dactinomycin; Dogs; Drug Therapy; Hydrocortisone; Lung; Lung Neoplasms; Methotrexate; Purines; Research; Spirometry; Transplantation Immunology; Transplantation, Autologous; Transplantation, Homologous	1964
Comparative effect of amethopterin and its 3',5'-dichloro derivative on purine biosynthesis in leukemic mice. Cancer research, 1960, Volume: 20 Topics: Animals; Folic Acid Antagonists; Leukemia; Metabolic Networks and Pathways; Methotrexate; Mice; Purines	1960
Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets. Journal of theoretical biology, 2006, Jun-21, Volume: 240, Issue:4 Topics: Antimetabolites, Antineoplastic; Computer Simulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Chemical; Purines; Quinazolines; Signal Transduction; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate	2006
Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside. Molecular cancer therapeutics, 2006, Volume: 5, Issue:9 Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA, Neoplasm; Drug Synergism; Enzyme Activation; Humans; Lipids; Methotrexate; Multienzyme Complexes; Nucleotide Deaminases; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Protein Serine-Threonine Kinases; Purines; Ribonucleosides; Ribonucleotides; RNA Interference	2006
Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis. The Journal of investigative dermatology, 2007, Volume: 127, Issue:8 Topics: 5' Untranslated Regions; Adenosine Deaminase; Adult; Folic Acid; Haplotypes; Humans; Hydroxymethyl and Formyl Transferases; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Genetic; Psoriasis; Purines; Pyrimidines; Reduced Folate Carrier Protein; Thymidylate Synthase	2007
Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians. Pharmacogenetics and genomics, 2009, Volume: 19, Issue:10 Topics: AMP Deaminase; Arthritis, Rheumatoid; Female; Genetic Variation; Humans; Hydroxymethyl and Formyl Transferases; India; Logistic Models; Male; Methotrexate; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Genetic; Purines	2009
DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma. Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytosol; DNA; Drug Monitoring; Erythrocytes; Female; Guanine Nucleotides; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thionucleotides	2010
Functional characterization and virulence study of ADE8 and GUA1 genes involved in the de novo purine biosynthesis in Candida albicans. FEMS yeast research, 2010, Volume: 10, Issue:2 Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Carbon-Nitrogen Ligases; Fungal Proteins; Gene Expression Regulation, Fungal; Humans; Male; Methotrexate; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Phosphoribosylglycinamide Formyltransferase; Purines; Uracil; Virulence	2010
Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity. Biochemical pharmacology, 1981, Sep-01, Volume: 30, Issue:17 Topics: Alanine; Animals; Azaserine; Cell Line, Tumor; Cell Survival; Diazooxonorleucine; Dose-Response Relationship, Drug; Fluorouracil; Methotrexate; Nucleic Acid Synthesis Inhibitors; Purines; Thioinosine; Thionucleotides; Uracil Nucleotides	1981
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell death & disease, 2013, Oct-24, Volume: 4 Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Carrier Proteins; Cell Line, Tumor; Embryonic Stem Cells; Energy Metabolism; Fatty Acids; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Glycine; Humans; Male; Metabolic Flux Analysis; Metabolic Networks and Pathways; Methotrexate; Mice; Multienzyme Complexes; NADP; Neoplasms; Protein Biosynthesis; Purines; Serine; Transferases	2013
The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell reports, 2016, Feb-02, Volume: 14, Issue:4 Topics: AMP-Activated Protein Kinases; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line; Cell Line, Tumor; Drug Resistance, Neoplasm; ERRalpha Estrogen-Related Receptor; Female; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Mice; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Purines; Receptors, Estrogen; Transcription Factors	2016
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation. Cell host & microbe, 2021, 03-10, Volume: 29, Issue:3 Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Bacteria; Female; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Metabolomics; Methotrexate; Mice; Mice, Inbred C57BL; Phylogeny; Purines; Pyrimidines; RNA, Ribosomal, 16S; Tetrahydrofolate Dehydrogenase; Transcriptome	2021