purine has been researched along with mercaptopurine in 137 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 131 (95.62) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (0.73) | 29.6817 |
2010's | 5 (3.65) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Bökkerink, JP; De Abreu, RA; De Bruyn, CH; De Vaan, GA; Lippens, RJ; Schouten, TJ; Van Laarhoven, JP | 1 |
Ahment, K; Bokkerink, JP; Brouwer, C; De Abreu, RA; Keizer-Garritsen, JJ; Lambooy, LH; Trijbels, FJ | 1 |
CLARKE, DA; ELION, GB; HITCHINGS, GH; PHILIPS, FS; STERNBERG, SS; STOCK, CC | 1 |
ELION, GB; HITCHINGS, GH; SINGER, S | 2 |
BURCHENAL, JH; CRAVER, LF; DARGEON, HW; ELLISON, RR; KARNOFSKY, DA; LEONE, LA; MURPHY, ML; RHOADS, CP; SYKES, MP; TAN, TC | 1 |
BERNARD, J; DELTOUR, G | 1 |
LAW, LW | 1 |
AGGELER, PM; FEICHTMEIR, TV; HALL, BE; RICHARDS, MD; WILLETT, FM | 1 |
SCHMIDT, KH | 1 |
ELION, GB; HITCHINGS, GH; SKIPPER, HE; THOMSON, JR | 1 |
BURCHENAL, JH; ELLISON, RR; KARNOFSKY, DA; MERMANN, AC; MURPHY, ML; RHOADS, CP; SYKES, MP; TAN, CT; YUCEOGLU, M | 1 |
BURCHENAL, JH; RHOADS, CP | 1 |
BERNARD, J | 1 |
GOLDIN, A | 1 |
SANSONE, G | 1 |
DENNIS, D; GOLDIN, A; GREENHOUSE, SW; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM | 2 |
ATWATER, J; GRUENSTEIN, M; SHAY, H | 1 |
MAZIMA, K; MIZUNOE, S; NOMURA, T; YAMAMOTO, S | 1 |
HAYHOE, FG | 1 |
FRIEDKIN, M | 1 |
MARINHO, HM | 1 |
HALL, SC; HOOKER, JW; POWELL, LW | 1 |
GASSER, C; HITZIG, W | 1 |
LENHARTZ, H | 1 |
FERNANDES, JF; LEPAGE, GA; LINDNER, A | 1 |
BECK, RE; MOFFAT, RG; PERRY, WH; WHITELAW, DM | 1 |
GHARPURE, VV; KARAMCHANDANI, PV; NAIDU, VR | 1 |
BERMAN, L; MOYNIHAN, JW | 1 |
BOUVIER, C; DUBOIS-FERRIERE, H; HAUSSER, A; KALACI, J; SORG, D; VAUTHIER, J; ZUMSTEIN, P | 1 |
REMY, D | 1 |
FITZPATRICK, MM; GREIG, HB; LAIRD, MH; METZ, J; ZENTKOWSKY, D | 1 |
GAVOSTO, F; PILERI, A; VERGNANO, F | 1 |
DEYSSON, G; DEYSSON, M; TRUHAUT, R | 1 |
CLARKE, DA; ELION, GB; HITCHINGS, GH; STOCK, CC | 1 |
LOO, TL; MICHAEL, ME | 1 |
FEIGELSON, P; ULTMANN, JE | 2 |
LEPAGE, GA; SARTORELLI, AC | 1 |
OLSSON, G | 1 |
DUGGAN, DE; TITUS, E | 1 |
JONES, M; LEPAGE, GA | 1 |
BIEBER, S; ELION, GB; HITCHINGS, GH | 1 |
CALLAHAN, SW; ELION, GB; HITCHINGS, GH; RUNDLES, RW | 1 |
JAFFE, JJ; MAUTNER, HG | 1 |
HOLLAND, JF; SELAWRY, OS | 1 |
SELAWRY, OS | 1 |
FREI, E; GOLDIN, A; VENDITTI, JM | 1 |
HALL, RP | 1 |
LEONARD, EO; McMURTRAY, TR; ORME-JOHNSON, WH; SHIVE, W; SKINNER, CG | 1 |
DOYLE, RT; KODLIN, D; RIVERS, SL; WHITTINGTON, RM | 2 |
ALEXANDRE, GP; CALNE, RY; MURRAY, JE | 1 |
CALNE, RY | 1 |
COULTAS, MK; HUTCHISON, DJ | 1 |
GARRISON, FE; HOBSON, JB; ITOGA, T; LASZLO, J; RUNDLES, RW | 1 |
NOELL, CW; ROBINS, RK | 1 |
JEFFREY, JJ; SCHANKER, LS; TOCCO, DJ | 1 |
CALLAHAN, S; ELION, GB; HITCHINGS, GH; RUNDLES, RW | 1 |
HITCHINGS, GH | 1 |
BARKER, TL; BENNETT, LL; GOLDEN, J; SIMPSON, L | 1 |
BERGMANN, F; BURGER-RACHAMIMOV, H; TAMARI, M | 1 |
FRANC, Z; FRANCOVA, V; JELINEK, V | 1 |
BOOTH, BA; SARTORELLI, AC | 1 |
MAGASANIK, B; ZIMMERMAN, EF | 1 |
NANETTI, L; VALLINI, R | 1 |
HENDERSON, JF; MAZEL, P | 1 |
WOODLIFF, HJ | 1 |
ANDERSON, EP; BROCKMAN, RW | 1 |
BALIS, ME; SALSER, JS | 1 |
FREI, E; GOLD, GL; HALL, T; HOLLAND, JF; KRANT, M; MILLER, SO; REGELSON, W | 1 |
CUTTS, JH | 1 |
BENNETT, KJ; GILES, WG; HANSEN, HJ; NADLER, SB; VANDEVOORDE, JP | 1 |
BENDER, HS; DYER, E | 1 |
ASHTON, DM; GILBERT, WR; MCCOLLISTER, RJ; WYNGAARDEN, JB | 1 |
BRAGONIER, JR; CARVER, MJ; ROESKY, N | 1 |
NAGEL, R | 1 |
BIEBER, AL; BOOTH, BA; SARTORELLI, AC; UPCHURCH, HF | 1 |
LEVY, RN; RUOHANI, J; SAWITSKY, A | 1 |
GUTHRIE, R; LU, WC | 1 |
JUNGA, IG; LEPAGE, GA | 1 |
KORNACKA, L; MALEC, J; WOJNAROWSKA, M; ZAKRZEWSKI, K | 1 |
BICHEL, J; BJORNJENSEN, K; THORLING, EB | 1 |
ATKINSON, MR; MURRAY, AW | 1 |
BROCKMAN, RW; CHUMLEY, S | 1 |
OEHME, J | 1 |
BIEBER, R; BIEBER, S; HITCHINGS, GH | 1 |
HUTCHISON, DJ | 1 |
THIERSCH, JB | 1 |
BIESELE, JJ | 2 |
CLARKE, DA; PHILIPS, FS; STERNBERG, SS; STOCK, CC | 1 |
BOYLE, PJ; LAW, LW; TAORMINA, V | 1 |
SKIPPER, HE | 2 |
GELLHORN, A; HIRSCHBERG, E; KELLS, A; MURRAY, MR; PETERSON, ER | 1 |
CLARKE, DA; HAMILTON, S; PHILIPS, FS; STERNBERG, SS | 1 |
ALBERSTADT, N; BURCHENAL, JH; ELLISON, RR; KARNOFSKY, DA; KRAKOFF, I; MERMANN, AC; MURPHY, ML; MYERS, WP; SYKES, MP; TAN, TC; YUCEOGLU, M | 1 |
BROSS, ID | 1 |
FEICHTMEIR, TV; HALL, BE; RICHARDS, MD; WILLETT, FM | 1 |
BERNARD, J; SELIGMANN, M | 1 |
JIMENEZ DE ASUA, F | 1 |
BOURONCLE, B; DOAN, CA; WISEMAN, K | 1 |
FARBER, S | 1 |
PIERCE, M | 1 |
CRAGO, JA; RUNDLES, RW | 1 |
GELLHORN, A; HYMAN, GA; WOLFF, JA | 1 |
BETHELL, FH; THOMPSON, DS | 1 |
FOUNTAIN, JR | 2 |
DAMESHEK, W | 1 |
LEE, SL; ROSENTHAL, N; ROSENTHAL, RL | 1 |
SYDENSTRICKER, VP | 1 |
RICE, EC | 1 |
HILL, JM; LAJOUS, J | 1 |
LOZNER, EL | 1 |
NEWTON, WA | 1 |
REAM, CR; SAWITSKY, A | 1 |
COOPER, WM; GAFFNEY, PC | 1 |
DEMARSH, QB | 1 |
DEAMER, WC; GELLERT, SA; LEONARD, ME; LI, JG; METTIER, SR; PETRAKIS, NL; WOOD, DA | 1 |
WILSON, SJ | 1 |
BORRONE, C; ZUNIN, C | 1 |
ROUQUES, L | 1 |
LENZI, G | 1 |
LIEBERMAN, I; OVE, P | 1 |
FRONTINO, G; KATO, R; VASSANELLI, P | 1 |
KELLEY, GG; MONTGOMERY, JA; WHEELER, GP | 1 |
HALL, J; OZOA, N; PIERCE, M | 1 |
Dalhoff, K; Hedeland, RL; Hvidt, K; Lausen, B; Nersting, J; Rosthøj, S; Schmiegelow, K | 1 |
Coulthard, SA; Hall, AG; Hogarth, LA; Jakobsen-Falk, I; Lindqvist-Appell, M; Redfern, CP; Skoglund, K; Taylor, GA; Vikingsson, S | 1 |
de Boer, NK; de Meij, T; van Bodegraven, AA | 1 |
Bai, Y; Chen, H; Chen, J; Chen, S; Chen, Y; Ding, J; Ding, L; Du, A; Ferrando, A; Gu, L; Huang, X; Jin, L; Kang, H; Kirschner-Schwabe, R; Li, B; Li, H; Li, W; Liang, H; Lu, G; Lu, H; Ma, X; Shen, S; Tang, J; Tzoneva, G; von Stackelberg, A; Wang, S; Wu, T; Yang, JJ; Yang, M; Zhang, J; Zhou, BB | 1 |
Ambesi-Impiombato, A; Basso, G; Dieck, CL; Ferrando, AA; Gastier-Foster, JM; Iacobucci, I; Kato, M; Khiabanian, H; Kirschner-Schwabe, R; Koh, K; Loh, ML; Madubata, CJ; Mullighan, CG; Oshima, K; Paganin, M; Rabadan, R; Sánchez-Martín, M; Sulis, ML; Tzoneva, G; Waanders, E; Yu, J | 1 |
3 review(s) available for purine and mercaptopurine
Article | Year |
---|---|
6-mercaptopurine: efficacy and bone marrow toxicity in childhood acute lymphoblastic leukemia. Association with low (thio)purine enzyme activity.
Topics: Antimetabolites, Antineoplastic; Bone Marrow; Child; Humans; Mercaptopurine; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines | 2000 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
[THE PRESENT STATUS OF KIDNEY TRANSPLANTATION].
Topics: Azathioprine; Dactinomycin; Immune Tolerance; Immunity; Immunosuppressive Agents; Kidney Transplantation; Mercaptopurine; Purines; Radiation Effects; Research; Transplantation Immunology; Transplantation, Heterologous; Transplantation, Homologous; Twins | 1964 |
134 other study(ies) available for purine and mercaptopurine
Article | Year |
---|---|
[6-Mercaptopurine and methotrexate, rational use in sight after 35 years?].
Topics: Animals; Child; Dogs; Half-Life; Humans; Infusions, Parenteral; Leukemia, Lymphoid; Lymphocytes; Mercaptopurine; Methotrexate; Purines; Pyrimidines | 1984 |
6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals.
Topics: Animals; Mercaptopurine; Mice; Purines; Sarcoma 180; Sarcoma, Experimental | 1953 |
The purine metabolism of a 6-mercaptopurine-resistant Lactobacillus casei.
Topics: Lacticaseibacillus casei; Lactobacillus; Mercaptopurine; Metabolic Networks and Pathways; Purines | 1953 |
Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases.
Topics: Antimetabolites; Leukemia; Mercaptopurine; Purines | 1953 |
[New therapy of leukoses; triethylene phosphoramide; G. T. 41 (myleran); 6-mercaptopurine; beta-mercaptoethylamine; massive doses of cortisone].
Topics: Busulfan; Cortisone; Cysteamine; Ethylamines; Leukemia; Mercaptopurine; Phosphoramides; Phosphorus; Phosphorus, Dietary; Purines; Triethylenephosphoramide | 1953 |
Resistance in leukemic cells to an adenine antagonist, 6-mercaptopurine.
Topics: Adenine; Animals; Humans; Leukemia, Experimental; Mercaptopurine; Purines | 1953 |
Evaluation of 6-mercaptopurine in the treatment of leukemia; a preliminary report.
Topics: Leukemia; Mercaptopurine; Purines | 1953 |
[Experimental and comparative results with triethylene melamine, N,N',N"-triethylene phosphoramide and 6-mercaptopurine].
Topics: Animals; Leukemia; Leukemia, Experimental; Mercaptopurine; Mitosis; Neoplasms, Experimental; Phosphoramides; Poisons; Purines; Triethylenemelamine; Triethylenephosphoramide | 1954 |
Observations on the anticancer activity of 6-mercaptopurine.
Topics: Animals; Mercaptopurine; Neoplasms, Experimental; Purines | 1954 |
Clinical evaluation of 6-mercaptopurine in the treatment of leukemia.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Clinical evaluation of 6-mercaptopurine in the treatment of leukemia.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
[6-mercaptopurine].
Topics: Mercaptopurine; Metabolism; Purines | 1954 |
Demonstration of protection against the lethal toxicity of 6-mercaptopurine in mice.
Topics: Animals; Mercaptopurine; Mice; Nucleotides; Purines | 1954 |
[Atypical myeloerythropoiesis with giant plurinucleated elements in child with Hodgkin's disease treated with 6-mercaptopurine; preventive note].
Topics: Child; Hematopoiesis; Hodgkin Disease; Humans; Mercaptopurine; Purines | 1954 |
An investigation into the synergistic antileukemic action of amethopterin and 6-mercaptopurine in mice.
Topics: Animals; Folic Acid Antagonists; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Purines | 1955 |
6-MERCAPTOPURINE and nucleic acid synthesis.
Topics: Humans; Mercaptopurine; Nucleic Acids; Purines | 1955 |
Effect of triethylene thiophosphoramide and 6-mercaptopurine in chronic myelogenous and in an acute leukemia in rats.
Topics: Animals; Leukemia; Leukemia, Experimental; Mercaptopurine; Phosphorus; Purines; Rats; Thiotepa | 1955 |
[Effect of 6-mercaptopurine on inplanted malignant tumor of animal].
Topics: Animals; Mercaptopurine; Neoplasms; Neoplasms, Experimental; Purines | 1955 |
6-Mercaptopurine in acute leukaemia.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1955 |
The enzymic synthesis of 6-mercaptopurine deoxyriboside.
Topics: Mercaptopurine; Purines | 1955 |
[A synthetic antileukemic agent, 6-mercaptopurine].
Topics: Antineoplastic Agents; Leukemia; Mercaptopurine; Purines | 1955 |
Acute monocytic leukemia: report of a case treated with cortisone and 6-mercaptopurine.
Topics: Cortisone; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Mercaptopurine; Purines | 1956 |
[6-Mercaptopurine (purinethol) in the treatment of leukemia in children; comparison with cortisone and aminopterin].
Topics: Aminopterin; Child; Cortisone; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1955 |
[Purinethol treatment of acute myeloblastic leukemia].
Topics: Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Purines | 1955 |
The influence of azaserine and 6-mercaptopurine on the in vivo metabolism of ascites tumor cells.
Topics: Animals; Anti-Bacterial Agents; Ascites; Azaserine; Carcinoma, Ehrlich Tumor; Mercaptopurine; Neoplasms; Purines | 1956 |
Acute leukaemia in adults treated with 6-mercaptopurine.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1956 |
6-Mercaptopurine in acute lymphocytic leukaemia.
Topics: Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines | 1956 |
Acute leukemia in adults; treatment with the combined use of ACTH or cortisone and 6 mercaptopurine.
Topics: Acute Disease; Adrenocorticotropic Hormone; Cortisone; Leukemia; Mercaptopurine; Purines | 1956 |
[Cortisone in massive doses and 6-mercaptopurine in the treatment of acute leucemias in adult; possibility of producing successive remissions].
Topics: Cortisone; Leukemia; Mercaptopurine; Neoplasms; Purines | 1956 |
[6-Mercaptopurine (purinethol) in therapy of myeloid leukemia].
Topics: Humans; Leukemia; Leukemia, Myeloid; Mercaptopurine; Purines | 1956 |
Chemotherapy of leukaemia. II. 6-Mercaptopurine (purinethol) in the treatment of acute leukaemia and some other neoplastic diseases of the reticuloendothelial system.
Topics: Leukemia; Mercaptopurine; Mononuclear Phagocyte System; Neoplasms; Purines | 1956 |
[Experimental research on the mechanism of action of antipurines; influence of 6-mercaptopurine on nucleic acid of regenerated rat liver].
Topics: Animals; Liver; Mercaptopurine; Nucleic Acids; Purines; Rats | 1956 |
[Effect of various purine antagonists (2-6-diaminopurine, 8-azaguanine and 6-mercaptopurine) on plant cell division].
Topics: 2-Aminopurine; Azaguanine; Cell Division; Mercaptopurine; Plants; Purines | 1956 |
Structure-activity relationships among purines related to 6-mercaptopurine.
Topics: Mercaptopurine; Purines; Structure-Activity Relationship | 1958 |
A colorimetric method for the determination of certain purine antagonists.
Topics: Antimetabolites; Colorimetry; Mercaptopurine; Purines | 1958 |
The effects of 8-azaguanine and 6-mercaptopurine on purine catabolism in the rat.
Topics: Animals; Azaguanine; Guanine; Mercaptopurine; Metabolic Networks and Pathways; Purines; Rats | 1958 |
Metabolic effects of 6-thioguanine. II. Biosynthesis of nucleic acid purines in vivo and in vitro.
Topics: In Vitro Techniques; Mercaptopurine; Metabolic Networks and Pathways; Nucleic Acids; Purines; Thioguanine | 1958 |
[Acute leukemia in children treated with meticorten & purinethol].
Topics: Acute Disease; Child; Humans; Infant; Leukemia; Mercaptopurine; Prednisone; Purines | 1959 |
6-Chloropurine and 6-chlorouric acid as substrates and inhibitors of purine-oxidizing enzymes.
Topics: Mercaptopurine; Metabolic Networks and Pathways; Purines; Uric Acid | 1959 |
Purinethiols as feedback inhibitors of purine synthesis in ascites tumor cells.
Topics: Animals; Antineoplastic Agents; Ascites; Carcinoma, Ehrlich Tumor; Humans; Mercaptopurine; Purines; Sulfhydryl Compounds | 1961 |
The effects of 8-azaguanine and 6-mercaptopurine on purine catabolism in the rat.
Topics: Animals; Antineoplastic Agents; Azaguanine; Mercaptopurine; Purines; Rats | 1960 |
A summary of investigations with 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in animals.
Topics: Mercaptopurine; Purines | 1960 |
The metabolism of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in man.
Topics: Mercaptopurine; Purines | 1960 |
A comparison of the biological properties of 6-selenopurine, 6-selenopurine ribonucleoside, and 6-mercaptopurine in mice.
Topics: Animals; Mercaptopurine; Mice; Purines; Ribonucleosides; Selenium | 1960 |
Tolerance to weekly doses of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]-purine (B.W. 57-323) in humans.
Topics: Drug Tolerance; Immune Tolerance; Mercaptopurine; Purines | 1960 |
Effect of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (imidazolylthioguanine; B.W. 57-323) on acute leukemia in man.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1960 |
The effectiveness of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio] purine against transplantable mouse leukemia.
Topics: Animals; Leukemia; Leukemia, Experimental; Mercaptopurine; Purines | 1960 |
Attempts to induce double resistance to drugs in the flagellate, Chilomonas paramecium.
Topics: Cryptophyta; Eukaryota; Humans; Mercaptopurine; Paramecium; Purines | 1962 |
2-Hydroxy derivatives of some biologically active 6-(substituted) purines.
Topics: Mercaptopurine; Oxidoreductases; Purines | 1962 |
Acute leukemia in the adult male. I. Comparative effect of 6-mercaptopurine and 6-chloropurine.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1963 |
Acute leukemia in the adult male. I. Comparative effect of 6-mercaptopurine and 6-chloropurine.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1962 |
A study of the effects of drugs in prolonging survival of homologous renal transplants in dogs.
Topics: Animals; Cyclophosphamide; Dactinomycin; Dogs; Kidney; Kidney Transplantation; Mercaptopurine; Nitrogen Mustard Compounds; Purines; Radiation Effects | 1962 |
Inhibition of the rejection of renal homografts in dogs by drugs.
Topics: Allografts; Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Dogs; Humans; Imidazoles; Kidney Transplantation; Mechlorethamine; Mercaptopurine; Purines; Radiation Effects; Transplantation, Homologous | 1963 |
Metabolism of resistant mutants of Streptococcus faecalis. IV. Use of a biophotometer in growth-curve studies.
Topics: Azaguanine; Drug Resistance, Microbial; Enterococcus faecalis; Mercaptopurine; Photometry; Purines | 1962 |
Clinical and hematologic study of 6[(1-methyl-4-nitro-5-imidazolyl)thio]-purine (B.W.57-322) and related compounds.
Topics: Humans; Imidazoles; Mercaptopurine; Purines | 1961 |
POTENTIAL PURINE ANTAGONISTS. XXXI. THE PREPARATION OF CERTAIN 9-ALKYL-2-AMINO-6-PURINETHIOLS AND RELATED DERIVATIVES AS ANTITUMOR AGENTS.
Topics: Adenocarcinoma; Antimetabolites; Antineoplastic Agents; Chemical Phenomena; Chemistry; Mercaptopurine; Pharmacology; Purines; Research; Sulfhydryl Compounds; Thioguanine | 1962 |
INTERACTION OF PURINES WITH THE PYRIMIDINE TRANSPORT PROCESS OF THE SMALL INTESTINE.
Topics: Adenine; Caffeine; Carbon Isotopes; Guanine; Intestine, Small; Intestines; Mercaptopurine; Pharmacology; Physiology; Purines; Pyrimidines; Rats; Research; Theobromine; Theophylline; Uracil; Uric Acid; Xanthines | 1963 |
RELATIONSHIP BETWEEN METABOLIC FATES AND ANTITUMOR ACTIVITIES OF THIOPURINES.
Topics: Animals; Antineoplastic Agents; Mercaptopurine; Metabolism; Mice; Purines; Sulfhydryl Compounds; Sulfur Isotopes; Urine | 1963 |
SUMMARY OF INFORMAL DISCUSSION ON THE ROLE OF PURINE ANTAGONISTS.
Topics: Antimetabolites; Gout; Humans; Leukemia; Mercaptopurine; Pharmacology; Psoriasis; Purines; Pyrazoles; Pyrimidines | 1963 |
THE PRIMARY SITE OF INHIBITION BY 6-MERCAPTOPURINE ON THE PURINE BIOSYNTHETIC PATHWAY IN SOME TUMORS IN VIVO.
Topics: Animals; Biosynthetic Pathways; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Formates; Glycine; Leukemia L1210; Mercaptopurine; Metabolism; Nucleotides; Purines; Research; RNA; RNA, Neoplasm; Sarcoma 180 | 1963 |
EVIDENCE FOR DIFFERENT ACTIVATION MECHANISMS IN THE OXIDATION OF 6-OXO- AND 6-THIOPURINES BY MAMMALIAN XANTHINE OXIDASE.
Topics: Animals; Chemical Phenomena; Chemistry; Mammals; Mercaptopurine; Oxidation-Reduction; Oxidoreductases; Purines; Research; Xanthine Oxidase | 1963 |
[RESORPTION, DISTRIBUTION IN THE TISSUES AND EXCRETORY ACTIVITY AFTER ADMINISTRATION OF S35-LABELLED-BUTHIOPURINE IN MICE].
Topics: Animals; Feces; Mercaptopurine; Metabolism; Mice; Purines; Research; Sarcoma 180; Sulfur Isotopes; Urine | 1963 |
GROWTH INHIBITION OF A SPECTRUM OF TRANSPLANTED MOUSE TUMORS BY COMBINATIONS OF INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS AND ALKYLATING AGENTS.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; DNA; DNA, Neoplasm; Fluorouracil; Idoxuridine; Liver Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nucleosides; Nucleotides; Purines; Research; RNA; RNA, Neoplasm; Sarcoma 180; Thioguanine; Uracil Mustard | 1963 |
UTILIZATION AND INTERCONVERSION OF PURINE BASES AND RIBONUCLEOSIDES BY SALMONELLA TYPHIMURIUM.
Topics: Adenine; Adenine Nucleotides; Carbon Isotopes; Chromatography; Culture Media; Guanine; Guanine Nucleotides; Histidine; Mercaptopurine; Metabolism; Nucleosides; Purines; Research; Ribonucleosides; Salmonella typhimurium; Spectrophotometry | 1964 |
[PRESENT STATE OF ANTINEOPLASTIC CHEMOTHERAPY FROM THE PHARMACOLOGIC POINT OF VIEW].
Topics: Acridines; Antineoplastic Agents; Arsenicals; Azaguanine; Azaserine; Busulfan; Cell Division; Chloramines; Colchicine; Humans; Mercaptopurine; Pharmacology; Purines; Thiotepa; Triethylenemelamine | 1963 |
DEMETHYLATION OF PURINE ANALOGS BY MICROSOMAL ENZYMES FROM MOUSE LIVER.
Topics: Animals; Antimetabolites; Caffeine; Carcinoma; Carcinoma, Ehrlich Tumor; Liver; Mercaptopurine; Metabolism; Mice; Purines; Pyrimidines; Research; Sulfhydryl Compounds; Theobromine; Theophylline | 1964 |
IN-VITRO SENSITIVITY TESTS OF LEUKAEMIC CELLS TO CHEMOTHERAPEUTIC AGENTS.
Topics: Aminopterin; Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Geriatrics; Histological Techniques; Hydrocortisone; Leukemia; Leukemia, Lymphoid; Leukocytosis; Mercaptopurine; Methotrexate; Mice; Polycythemia Vera; Purines; Research; Tissue Culture Techniques | 1964 |
THE INTERCONVERSION OF PURINES BY TUMORS AND THE ACTION OF ANTI-PURINES.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Azaguanine; Carbon Isotopes; Glycine; Guanine Nucleotides; Imidazoles; Liver; Lyases; Mercaptopurine; Metabolism; Mice; Neoplasms, Experimental; Nucleotides; Pharmacology; Purines; Research; Sarcoma 180; Thioguanine | 1964 |
COMPARATIVE CLINICAL TOXICITY OF 6-MERCAPTOPURINE (NSC-755)-1 AND 6-MERCAPTOPURINE RIBONUCLEOSIDE (NSC-4911)-2 ADMINISTERED INTRAVENOUSLY TO PATIENTS WITH ADVANCED CANCER.
Topics: Bone Marrow; Injections, Intravenous; Leukopenia; Mercaptopurine; Mice; Neoplasms; Nucleosides; Pharmacology; Purines; Pyrimidines; Research; Thioinosine; Thrombocytopenia; Toxicology | 1964 |
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE.
Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cortisone; Glutamates; Leukemia; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Pharmacology; Purines; Research; Tryptophan; Vinblastine | 1964 |
AZASERINE AND THIOPURINES. I. INHIBITION OF S-180 MOUSE TUMOR AND ANTIBODY SYNTHESIS.
Topics: Alkylating Agents; Animals; Antibody Formation; Antineoplastic Agents; Azaserine; Imidazoles; Mercaptopurine; Mice; Pharmacology; Purines; Rats; Research; Sarcoma 180; Tetanus Toxoid; Thioguanine; Toxicology | 1964 |
DERIVATIVES OF PURINETHIOLS. PURINE THIOLCARBONATES AND RELATED COMPOUNDS.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carbonates; Chemistry, Pharmaceutical; Leukemia L1210; Mercaptopurine; Mice; Purines; Research; Sarcoma 180; Tissue Culture Techniques | 1964 |
PSEUDOFEEDBACK INHIBITION OF PURINE SYNTHESIS BY 6-MERCAPTOPURINE RIBONUCLEOTIDE AND OTHER PURINE ANALOGUES.
Topics: Adenine Nucleotides; Antimetabolites; Antineoplastic Agents; Azaguanine; Chromatography; Diphosphates; Enzyme Inhibitors; Glutamine; Mercaptopurine; Nucleotides; Purines; Pyrazoles; Pyrimidines; Research; Thioguanine; Transferases; Ultraviolet Rays | 1964 |
TERATOGENESIS: EFFECTS OF SUBSTITUTED PURINES AND THE INFLUENCE OF 4-HYDROXYPYRAZOLOPYRIMIDINE IN THE RAT.
Topics: Abnormalities, Drug-Induced; Adenine; Female; Mercaptopurine; Neoplasms; Neoplasms, Experimental; Pharmacology; Placenta; Pregnancy; Purines; Pyrazoles; Pyrimidines; Rats; Research; Teratogenesis; Thioguanine; Toxicology | 1964 |
SOME METABOLIC EFFECTS EXERTED BY AZASERINE AND PURINE ANALOGS IN VIVO.
Topics: Adenine; Amino Acids; Animals; Antimetabolites; Antineoplastic Agents; Azaserine; Carbon Isotopes; Glycine; Guanine; Mercaptopurine; Metabolism; Mice; Neoplasm Transplantation; Nucleotides; Pharmacology; Purines; Research; Sarcoma 180 | 1964 |
DRUG FEVER PRODUCED BY SIX-MERCAPTOPURINE.
Topics: Adenine; Antineoplastic Agents; Drug Therapy; Fever; Hematocrit; Leukemia; Leukocyte Count; Mercaptopurine; Purines; Thioguanine; Toxicology | 1964 |
ANTAGONISM BETWEEN PURINES IN PURINE-REQUIRING BACILLUS SUBTILIS MUTANTS.
Topics: 2-Aminopurine; Adenine; Adenine Nucleotides; Azaguanine; Bacillus subtilis; Guanine; Guanine Nucleotides; Hypoxanthines; Mercaptopurine; Metabolism; Mutation; Nucleosides; Nucleotides; Pharmacology; Purines; Research; Xanthines | 1964 |
METABOLISM OF PURINE NUCLEOSIDE ANALOGS.
Topics: Adenine; Animals; Antimetabolites; Guanine; Mercaptopurine; Metabolism; Mice; Neoplasms; Neoplasms, Experimental; Nucleosides; Purine Nucleosides; Purines; Research | 1965 |
EFFECT OF PURINES AND SOME OF THEIR ANALOGUES ON PROTEIN AND RNA SYNTHESIS IN ISOLATED NUCLEI.
Topics: Antibody Formation; Antimetabolites; Antineoplastic Agents; Carbon Isotopes; Cell Nucleus; Cytosine; Guanine; Leucine; Leukocytes; Lysine; Mercaptopurine; Metabolism; Orotic Acid; Pharmacology; Proteins; Purines; Research; RNA; Thioguanine; Uracil; Uric Acid; Xanthines | 1964 |
ON THE EFFECT OF BUTHIOPURINE IN ACUTE LEUKAEMIA.
Topics: Antineoplastic Agents; Drug Therapy; Humans; Leukemia; Leukemia, Myeloid; Mercaptopurine; Prognosis; Purines | 1964 |
INHIBITION OF PRUINE PHOSPHORIBOSYLTRANSFERASES OF EHRLICH ASCITES-TUMOUR CELLS BY 6-MERCAPTOPURINE.
Topics: Adenine; Adenine Nucleotides; Adenosine Monophosphate; Animals; Ascites; Carcinoma, Ehrlich Tumor; Diphosphates; Electrophoresis; Enzyme Inhibitors; Glucosyltransferases; Guanine; Guanine Nucleotides; Hypoxanthines; Kinetics; Mercaptopurine; Nucleotides; Pharmacology; Purines; Research; Spectrophotometry; Transferases; Xanthines | 1965 |
INHIBITION OF FORMYLGLYCINAMIDE RIBONUCLEOTIDE SYNTHESIS IN NEOPLASTIC CELLS BY PURINES AND ANALOGS.
Topics: Adenine; Animals; Antimetabolites; Antineoplastic Agents; Azaserine; Carcinoma, Squamous Cell; Glycine; Hypoxanthines; Imidazoles; Leukemia L1210; Mercaptopurine; Nucleotides; Pharmacology; Purines; Research; Ribonucleotides; Thioguanine; Tissue Culture Techniques; Xanthines | 1965 |
[Purinethol therapy leukoses of childhood].
Topics: Child; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1955 |
Microbiological effects of 6-mercaptopurine.
Topics: Humans; Lactobacillus; Mercaptopurine; Purines | 1954 |
Activities of 6-mercaptopurine and related compounds on embryonic and regenerating tissues of Rana pipiens.
Topics: Animals; Mercaptopurine; Purines; Rana pipiens; Wound Healing | 1954 |
Biological activities of 6-mercaptopurine: effects on Streptococcus faecalis.
Topics: Enterococcus faecalis; Humans; Mercaptopurine; Purines; Streptococcus | 1954 |
The effect of 6-mercaptopurine on the rat fetus and on reproduction of the rat.
Topics: Animals; Fetus; Mercaptopurine; Purines; Rats; Reproduction | 1954 |
Effects of 6-mercaptopurine on experimental tumors in tissue culture.
Topics: Animals; Mercaptopurine; Neoplasms, Experimental; Purines; Sarcoma, Experimental; Tissue Culture Techniques | 1954 |
Effects of 6-mercaptopurine and analogs on experimental tumors.
Topics: Humans; Mercaptopurine; Neoplasms; Neoplasms, Experimental; Purines | 1954 |
Response of acute lymphocytic leukemias to the purine antagonist 6-mercaptopurine.
Topics: Acute Disease; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines | 1954 |
Studies on the toxicity and antileukemic action of 6-mercaptopurine in mice.
Topics: Animals; Leukemia, Experimental; Mercaptopurine; Mice; Purines | 1954 |
Effects of 6-mercaptopurine on experimental tumors.
Topics: Animals; Mercaptopurine; Neoplasms, Experimental; Purines | 1954 |
The effects of 6-mercaptopurine, 8-azaguanine, and 1,4-dimethanesulfonyloxybutane on an experimental brain tumor: preliminary observations.
Topics: Animals; Azaguanine; Brain; Brain Neoplasms; Glycols; Guanine; Mercaptopurine; Neoplasms, Experimental; Purines | 1954 |
The toxic effects of 6-mercaptopurine and related compounds.
Topics: Humans; Mercaptopurine; Purines | 1954 |
On the mechanism of action of 6-mercaptopurine.
Topics: Humans; Mercaptopurine; Purines | 1954 |
Clinical studies on 6-mercaptopurine.
Topics: Mercaptopurine; Neoplasms; Purines | 1954 |
Statistical analysis of clinical results from 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Clinical experience with 6-mercaptopurine in human neoplasia.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
A study of 61 leukemias treated with 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
The treatment of blastic leukemias with 6-mercaptopurine.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1954 |
One-year evaluation of 6-mercaptopurine in the treatment of leukemia.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Summary of experience with 6-mercaptopurine.
Topics: Mercaptopurine; Neoplasms; Purines | 1954 |
Leukemia in children: treatment of 22 cases with 6-mercaptopurine.
Topics: Child; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1954 |
6-Mercaptopurine therapy in neoplastic disease.
Topics: Mercaptopurine; Neoplasms; Purines | 1954 |
The therapeutic effect of mercaptopurine in a variety of human neoplastic diseases.
Topics: Mercaptopurine; Neoplasms; Purines | 1954 |
Treatment of leukemia and related disorders with 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
Clinical observations of the treatment of leukemia and allied disorders with 6-mercaptopurine.
Topics: Arylsulfonates; Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
The use of 6-mercaptopurine in acute leukemia.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1954 |
Role of mercaptopurine in the treatment of leukemia and related diseases.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
Report on 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Results obtained in the treatment of acute leukemia and lymphosarcoma with 6-mercaptopurine.
Topics: Humans; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Purines | 1954 |
6-Mercaptopurine therapy in leukemia.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
6-Mercaptopurine in acute leukemia.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1954 |
Clinical experience using 6-mercaptopurine in childhood leukemia.
Topics: Child; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1954 |
Clinical evaluation of 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
A clinical study of 6-mercaptopurine.
Topics: Biomedical Research; Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
The treatment of leukemia with 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
The effect of 6-mercaptopurine in acute leukemia of children and adults: a preliminary report.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1954 |
The clinical and hematological response of previously treated leukemic subjects to the antimetabolite 6-mercaptopurine.
Topics: Antimetabolites; Leukemia; Mercaptopurine; Purines | 1954 |
[Teratogenic effect of 6-mercaptopurine].
Topics: Abnormalities, Severe Teratoid; Mercaptopurine; Purines | 1955 |
MERCAPTOPURINE in leukemia.
Topics: Humans; Leukemia; Mercaptopurine; Purines | 1955 |
Treatment of leukaemia and allied disorders with 6-mercaptopurine.
Topics: Arylsulfonates; Leukemia; Mercaptopurine; Purines | 1955 |
[6-Mercaptopurine in therapy of leukemia].
Topics: Leukemia; Mercaptopurine; Purines | 1955 |
Antagonistic effects of 6-mercaptopurine and coenzyme A on mitochondria and mitosis in tissue culture.
Topics: Animals; Antimetabolites; Cell Division; Coenzyme A; Coenzymes; Cytoplasm; Fibroblasts; Mercaptopurine; Mice; Mitochondria; Mitosis; Purines; Sarcoma 180; Tissue Culture Techniques | 1955 |
[Early impressions of a case of acute infantile leukemia during 6-mercaptopurine therapy].
Topics: Acute Disease; Child; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1955 |
Enzyme studies with mutant mammalian cells.
Topics: Animals; Enzymes; Humans; Mercaptopurine; Purines; Research; Tissue Culture Techniques | 1960 |
Comparative study of inhibitory action of ethionine, 8-azaguanine, 6-mercaptopurine and x- or gamma-irradiation on the induction of the hepatic drug-metabolizing enzymes by phenobarbital or phenaglycodol.
Topics: Antimetabolites; Azaguanine; Butylene Glycols; Enzymes; Ethionine; Meprobamate; Mercaptopurine; Pentobarbital; Phenobarbital; Purines; Radiation Effects; Tranquilizing Agents | 1961 |
The effects of a series of 9-alkylpurines on the growth of sensitive and 6-MP-resistant H. Ep. 2 cells.
Topics: Carcinoma; Carcinoma, Squamous Cell; Humans; Mercaptopurine; Purines | 1962 |
The effect of 6-mercaptopurine riboside in 20 cases of childhood leukemia previously treated with purine antimetabolites.
Topics: Antimetabolites; Child; Humans; Infant; Leukemia; Mercaptopurine; Purines; Thioinosine | 1961 |
DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytosol; DNA; Drug Monitoring; Erythrocytes; Female; Guanine Nucleotides; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thionucleotides | 2010 |
Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Deletion; Humans; Immunoblotting; Mercaptopurine; Neoplasms; Purine-Nucleoside Phosphorylase; Purines; Thioguanine; Thioinosine; Thionucleotides | 2011 |
Thiopurines during pregnancy in inflammatory bowel disease: is there a risk for the (unborn) child?
Topics: Anti-Inflammatory Agents; Azathioprine; Female; Fetus; Gastrointestinal Agents; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Pregnancy; Pregnancy Complications; Purines; Remission Induction; Risk Assessment; Risk Factors; Treatment Outcome | 2013 |
Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.
Topics: Adolescent; Child; Child, Preschool; Exome; Feedback, Physiological; Female; High-Throughput Nucleotide Sequencing; Humans; Infant; Leukemia, B-Cell; Male; Mercaptopurine; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Recurrence; Ribose-Phosphate Pyrophosphokinase; Tetrahydrofolates | 2015 |
Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia.
Topics: 5'-Nucleotidase; Animals; Cell Proliferation; Clonal Evolution; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gain of Function Mutation; Guanosine; HEK293 Cells; Humans; IMP Dehydrogenase; Male; Mercaptopurine; Mice; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Receptor, Notch1; Recurrence; Xenograft Model Antitumor Assays | 2018 |