purine has been researched along with folic acid in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (60.00) | 18.7374 |
| 1990's | 2 (4.44) | 18.2507 |
| 2000's | 4 (8.89) | 29.6817 |
| 2010's | 11 (24.44) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Moran, RG | 1 |
| Chanarin, I; Deacon, R; Lumb, M; Muir, M; Perry, J | 1 |
| Boritzki, TJ; Jackson, RC; Zhang, CC | 1 |
| SHIVE, W | 1 |
| BUCHANAN, JM; SCHULMAN, MP | 1 |
| TENTORI, L; VIVALDI, G | 1 |
| GREENBERG, GR | 1 |
| BURCHENAL, JH | 1 |
| BUSSI, L; ERIDANI, S; FAVA, PL; POZZA, G | 1 |
| FRIEDERICI, L | 1 |
| AARONSON, S; RODRIGUEZ, E | 1 |
| SHAW, E; VIEIRA, E | 1 |
| TIMMIS, GM | 1 |
| WILMANNS, W | 1 |
| ZAKRZEWSKI, SF | 1 |
| HUTCHISON, DJ; JOHNSON, AH | 1 |
| ALBRECHT, AM; HUTCHISON, DJ | 1 |
| ANDERSON, EP; BROCKMAN, RW | 1 |
| BROCKMAN, RW | 1 |
| WOODS, DD | 1 |
| NARKATES, AJ; PITTILLO, RF | 1 |
| COLLIN, R; PULLMAN, B | 1 |
| PRISTOUPILOVA, K; SLAVIK, K; SLAVIKOVA, V; SOUCEK, J | 1 |
| SPRECHER, M; SPRINSON, DB | 1 |
| LANSFORD, EM; SHIVE, W | 1 |
| LIEBERMAN, I; OVE, P | 1 |
| KALCKAR, HM; KJELDGAARD, NO; KLENOW, H | 1 |
| DRYSDALE, GR; LARDY, HA; PLAUT, GW | 1 |
| Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA | 1 |
| Chattopadhyay, S; Goldman, ID; Hanscom, M; Zhang, S; Zhao, R | 1 |
| Assaraf, YG; Ifergan, I; Kadry, WN; Pinter, RY | 1 |
| Arenas, M; Barker, JN; Campalani, E; Lewis, CM; Marinaki, AM; Smith, CH | 1 |
| ROGERS, LL; SHIVE, W | 1 |
| Abarinov, EV; Allen, RH; Beaudin, AE; Chu, S; Noden, DM; Perry, CA; Stabler, SP; Stover, PJ | 1 |
| Lin, DM; Macfarlane, AJ; McEntee, MF; Perry, CA; Stover, PJ | 1 |
| Bertino, JR; Boros, LG; Chan, LL; DiPaola, RS; Dolfi, SC; Dvorzhinski, D; Gounder, M; Hirshfield, KM; Lin, H; Markert, EK; Oltvai, ZN; Qiu, J; Tedeschi, PM; Vazquez, A | 1 |
| Hesdorffer, CS; Longo, DL | 1 |
| Chiang, EP; Ko, HA; Lin, YJ; Tang, FY; Wang, YC; Wu, MT | 1 |
| Audet-Walsh, É; Bourque, G; Bridon, G; Caron, M; Giguère, V; Gravel, SP; Papadopoli, DJ; St-Pierre, J; Yee, T | 1 |
| Butenko, A; Flegontov, P; Lukeš, J; Opperdoes, FR; Yurchenko, V | 1 |
| Asai, A; Doki, Y; Ishii, H; Kawamoto, K; Konno, M; Mori, M; Nishida, N; Satoh, T | 1 |
| Field, MS; Lan, X; Stover, PJ | 1 |
| Chang, S; Chen, X; Cheung, E; Cui, G; Guo, D; Hu, L; Lim, MGL; Luo, Y; Poudel, B; Robson, P; See, YX; Zhao, Z; Zhu, D | 1 |
| Chen, X; Gotoh, N; Horike, SI; Igarashi, K; Kato, K; Kita, K; Kohno, S; Meguro-Horike, M; Mukaida, N; Murayama, T; Nakata, A; Nishi, K; Nishimura, T; Saitoh, K; Sasaki, S; Soga, T; Takahashi, C; Tojo, A; Yano, S | 1 |
| Ghergurovich, JM; Rabinowitz, JD; Ryseck, RP; Wang, JZ; Wang, L; Xu, X; Yang, L | 1 |
8 review(s) available for purine and folic acid
| Article | Year |
|---|---|
Folate antimetabolites inhibitory to de novo purine synthesis.
Topics: Animals; Folic Acid; Mice; Purines; Tumor Cells, Cultured | 1991 |
Cobalamin-folate interrelations: a critical review.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central Nervous System; Deoxyuridine; Disease Models, Animal; Drug Interactions; Enzyme Activation; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Liver; Methionine; Methylmalonyl-CoA Mutase; Nitrous Oxide; Oxidation-Reduction; Pteroylpolyglutamic Acids; Purines; Serine; Tetrahydrofolates; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency | 1985 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS.
Topics: Alkylating Agents; Antineoplastic Agents; Azaserine; Dactinomycin; DNA; Drug Resistance; Drug Resistance, Microbial; Drug Tolerance; Folic Acid; Humans; Leucine; Metabolism; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Pyrimidines; RNA; Steroids; Tissue Culture Techniques | 1963 |
Drug-Induced Megaloblastic Anemia.
Topics: Anemia, Megaloblastic; DNA; Folic Acid; Gastrointestinal Absorption; Humans; Purines; Pyrimidines; Thymine Nucleotides; Vitamin B 12; Vitamin B 12 Deficiency | 2015 |
Comparative Metabolism of Free-living Bodo saltans and Parasitic Trypanosomatids.
Topics: Amino Acids; Bacteria; Carbohydrate Metabolism; Coenzymes; Dolichols; Ergosterol; Eukaryota; Folic Acid; Genes, Protozoan; Gluconeogenesis; Glycolysis; Kinetoplastida; Lipid Metabolism; Mevalonic Acid; Microbodies; Mitochondria; Oxidoreductases; Pentose Phosphate Pathway; Peroxisomes; Phospholipids; Polyamines; Protein Prenylation; Protozoan Proteins; Purines; Pyrimidines; Reactive Oxygen Species; Trypanosomatina; Ubiquinone; Urea; Vitamins | 2016 |
The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).
Topics: Aminohydrolases; Antineoplastic Agents; Fluorouracil; Folic Acid; Folic Acid Antagonists; Gastrointestinal Neoplasms; Glycine Hydroxymethyltransferase; Humans; Metabolic Networks and Pathways; Metabolome; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); MicroRNAs; Mitochondria; Molecular Targeted Therapy; Multienzyme Complexes; Nucleosides; Nucleotides; Oxidoreductases Acting on CH-NH Group Donors; Purines; Reactive Oxygen Species; Serine | 2017 |
Cell cycle regulation of folate-mediated one-carbon metabolism.
Topics: Animals; Carbon; Cell Cycle; Cytosol; Folic Acid; Humans; Metabolic Networks and Pathways; Mitochondria; Purines; Transcription Factors | 2018 |
1 trial(s) available for purine and folic acid
| Article | Year |
|---|---|
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12 | 2004 |
36 other study(ies) available for purine and folic acid
| Article | Year |
|---|---|
An inhibitor of glycinamide ribonucleotide formyltransferase is selectively cytotoxic to cells that lack a functional G1 checkpoint.
Topics: Animals; DNA, Neoplasm; Enzyme Inhibitors; Folic Acid; G1 Phase; Glutamates; HeLa Cells; Humans; Hydroxymethyl and Formyl Transferases; Mice; Phosphoribosylglycinamide Formyltransferase; Purines; Pyrimidines | 1998 |
The functions of B-vitamins in the biosynthesis of purines and pyrimidines.
Topics: Folic Acid; Purines; Pyrimidines; Vitamin B Complex; Vitamins | 1951 |
Biosynthesis of the purines. III. Reactions of formate and inosinic acid and an effect of the citrovorum factor.
Topics: Folic Acid; Formates; Inosine Monophosphate; Leucovorin; Nucleotides; Purines | 1953 |
[Variations in the blood content of some metabolites of proteins and purines in experimental anemia of folic acid deficiency in the rat].
Topics: Anemia; Animals; Folic Acid; Folic Acid Deficiency; Purines; Rats | 1953 |
Role of folic acid derivatives in purine biosynthesis.
Topics: Antimetabolites; Folic Acid; Humans; Purines | 1954 |
Clinical effects of analogs of folic acid, purines, pyrimidines, and amino acids.
Topics: Amino Acids; Folic Acid; Folic Acid Antagonists; Humans; Inorganic Chemicals; Leukemia; Purines; Pyrimidines | 1954 |
[Effects of various cytostimulating and cytoinhibiting factors on normal and pathological human hemopoietic bone marrow cultivated in vitro].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Aminopterin; Bone and Bones; Bone Marrow; Folic Acid; Humans; In Vitro Techniques; Purines | 1955 |
[Effect of purines, prohepar, hepanovin and nucleotrat on bone marrow cultures].
Topics: Bone Marrow; Corrinoids; Folic Acid; Hematinics; Humans; Liver Extracts; Nucleotides; Purines; Vitamin B 12 | 1956 |
Relationship between purines and folic acid-vitamins in the micrococcus, Gaffkya homari.
Topics: Folic Acid; Gram-Positive Cocci; Humans; Metabolic Networks and Pathways; Micrococcus; Purines; Streptococcaceae; Vitamins | 1958 |
The utilization of purines in the biosynthesis of folic acid.
Topics: Corynebacterium; Folic Acid; Humans; Metabolic Networks and Pathways; Purines | 1961 |
Antagonists of purine and pyrimidine metabolites and of folic acid.
Topics: Antimetabolites; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Humans; Purines; Pyrimidines | 1961 |
[On the mechanism of action of folic acid and purine antagonists in the treatment of acute leukemias].
Topics: Antimetabolites; Folic Acid; Leukemia; Purines | 1963 |
RELATIONSHIP BETWEEN BASICITY OF CERTAIN FOLATE ANALOGUES AND THEIR AFFINITIES FOR FOLATE REDUCTASE.
Topics: Enzyme Inhibitors; Folic Acid; Oxidoreductases; Pterins; Purines; Pyrimidines; Research | 1963 |
FOLIC ACID METABOLISM IN ANTIFOLIC-RESISTANT MUTANTS OF STREPTOCOCCUS FAECALIS.
Topics: Adenine; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Guanine; Metabolism; Methotrexate; Mutation; Purines; Research; Serine; Thymine; Xanthines | 1964 |
REPRESSION BY ADENINE OF THE FORMYLTETRAHYDROFOLATE SYNTHETASE IN AN ANTIFOLIC-RESISTANT MUTANT OF STREPTOCOCCUS FAECALIS.
Topics: Adenine; Bacteriological Techniques; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Formate-Tetrahydrofolate Ligase; Guanine; Ligases; Methotrexate; Mutation; Purines; Research; Tetrahydrofolate Dehydrogenase; Thymine | 1964 |
THE FUNCTION OF FOLIC ACID IN CELLULAR METABOLISM.
Topics: Biochemical Phenomena; Biochemistry; Celiac Disease; Diet; Folic Acid; Folic Acid Deficiency; Glutamates; Intestines; Metabolism; Methionine; Nucleotides; Purines; Sprue, Tropical; Sulfonamides | 1964 |
FOLIC ACID INHIBITION OF NON-PROLIFERATING BACTERIA.
Topics: Bacillus cereus; Bacteria; Bacteriological Techniques; Candida; Culture Media; Escherichia coli; Folic Acid; Metabolism; Methotrexate; Pharmacology; Pseudomonas aeruginosa; Purines; Research; Saccharomyces; Salmonella typhimurium; Staphylococcus | 1964 |
ON THE MECHANISM OF FOLIC ACID REDUCTASE INHIBITION.
Topics: Chemical Phenomena; Chemistry; Enzyme Inhibitors; Folic Acid; Oxidoreductases; Pterins; Purines; Pyrimidines; Research; Tetrahydrofolate Dehydrogenase | 1964 |
ON THE MECHANISM OF ACTION OF SOME 4-AMINOANALOGUES OF FOLIC ACID.
Topics: Aminopterin; Folic Acid; Folic Acid Antagonists; Metabolism; Mice; Nucleotides; Oxidoreductases; Pharmacology; Purines; Research; Toxicology; Transferases | 1964 |
METHYLATED PURINES AND PYRIMIDINES. II. SYNTHESIS AND PROPERTIES OF 2,6-DIAMINO-5-(METHYLAMINO)-4-PYRIMIDINOL.
Topics: Alkylation; Chemical Phenomena; Chemistry; Folic Acid; Glutamates; Guanine; Pterins; Purines; Pyrimidines; Research | 1965 |
A study of the interactions of folic acid analogues and 6-(substituted)purines as growth inhibitors.
Topics: Antimetabolites; Folic Acid; Folic Acid Antagonists; Growth Inhibitors; Humans; Lactobacillus; Leuconostoc; Purines | 1959 |
Control of growth of mammalian cells in culture with folic acid, thymidine, and purines.
Topics: Folic Acid; Nucleosides; Nucleotides; Purines; Thymidine; Tissue Culture Techniques | 1960 |
2-Amino-4hydroxy-6-formylpteridine, an inhibitor of purine and pterine oxidases.
Topics: Folic Acid; Humans; Oxidoreductases; Peroxidase; Peroxidases; Pterins; Purines | 1950 |
The relationship of folic acid to formate metabolism in the rat; formate incorporation into purines.
Topics: Animals; Folic Acid; Formates; Humans; Purines; Rats | 1951 |
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
Topics: Animals; Blotting, Western; Cattle; Cell Division; Cell Line, Tumor; Culture Media; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hypoxanthine; Leucovorin; Membrane Transport Proteins; Pemetrexed; Purines; Reduced Folate Carrier Protein; Serum; Thymidylate Synthase; Thymine | 2005 |
Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
Topics: Antimetabolites, Antineoplastic; Computer Simulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Chemical; Purines; Quinazolines; Signal Transduction; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate | 2006 |
Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis.
Topics: 5' Untranslated Regions; Adenosine Deaminase; Adult; Folic Acid; Haplotypes; Humans; Hydroxymethyl and Formyl Transferases; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Genetic; Psoriasis; Purines; Pyrimidines; Reduced Folate Carrier Protein; Thymidylate Synthase | 2007 |
Biochemical transformations as determined by competitive analogue-metabolite growth inhibitions; relationship of purines and thymine to folic acid.
Topics: Folic Acid; Organic Chemicals; Purines; Thymine; Vitamin B Complex; Vitamins | 1948 |
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Gene Expression; Glycine Hydroxymethyltransferase; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neural Tube Defects; Purines; Severity of Illness Index; Thymidine Monophosphate; Thymidylate Synthase; Vitamin B Complex | 2011 |
Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.
Topics: Adenomatous Polyposis Coli Protein; Animals; Blotting, Western; Cells, Cultured; Colon; Diet; Enterocytes; Epithelial Cells; Female; Folic Acid; Gene Expression Profiling; Glycine Hydroxymethyltransferase; Heterozygote; Immunohistochemistry; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Oligonucleotide Array Sequence Analysis; Purines; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Thymine Nucleotides | 2011 |
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells.
Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Carrier Proteins; Cell Line, Tumor; Embryonic Stem Cells; Energy Metabolism; Fatty Acids; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Glycine; Humans; Male; Metabolic Flux Analysis; Metabolic Networks and Pathways; Methotrexate; Mice; Multienzyme Complexes; NADP; Neoplasms; Protein Biosynthesis; Purines; Serine; Transferases | 2013 |
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Topics: Animals; Carbon; DNA Damage; DNA Methylation; Folic Acid; Genotype; Glycine N-Methyltransferase; Hep G2 Cells; Homocysteine; Humans; Liver; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Neoplasms; Nucleotides; Nutritional Status; Purines; S-Adenosylmethionine; Uracil | 2015 |
The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.
Topics: AMP-Activated Protein Kinases; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line; Cell Line, Tumor; Drug Resistance, Neoplasm; ERRalpha Estrogen-Related Receptor; Female; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Mice; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Purines; Receptors, Estrogen; Transcription Factors | 2016 |
Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer.
Topics: Breast Neoplasms; Carbon; Cell Proliferation; Cell Survival; Estrogens; Female; Folic Acid; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mitochondria; Polyamines; Purines; Signal Transduction; Single-Cell Analysis; Time Factors | 2018 |
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Topics: Aminohydrolases; Aminoimidazole Carboxamide; beta Catenin; Carcinogenesis; Cell Line; Cell Line, Tumor; Drug Resistance, Neoplasm; Folic Acid; Gefitinib; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Lung Neoplasms; Metabolic Networks and Pathways; Methylenetetrahydrofolate Dehydrogenase (NADP); Mitochondria; Multifunctional Enzymes; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Purines; Ribonucleotides | 2019 |
Methionine synthase supports tumour tetrahydrofolate pools.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Metabolic Networks and Pathways; Methionine; Methylation; Mutation; Neoplasms; Purines; Tetrahydrofolates; Vitamin B 12 Deficiency | 2021 |