pulmicort and coumarin

pulmicort has been researched along with coumarin* in 1 studies

Other Studies

1 other study(ies) available for pulmicort and coumarin

Article	Year
Wheat germ agglutinin-conjugated nanoparticles for sustained cellular and lung delivery of budesonide. Drug delivery, 2008, Volume: 15, Issue:2 The purpose of our studies was to assess in vitro nanoparticles cellular uptake and cellular budesonide levels after treatment of alveolar epithelial cell lines with wheat germ agglutinin (WGA)-conjugated budesonide nanoparticles and pharmacokinetic evaluation of drug after intratracheal instillation of nanoparticles in rats. Confocal microscopy was used to study the cellular uptake of nanoparticles, and the cellular and lung tissue drug levels were estimated by HPLC. Higher amount of fluorescence observed in the cells treated with WGA nanoparticles, higher and sustained cellular drug levels, and better bioavailability in lungs of WGA-conjugated nanoparticles indicate superiority of WGA-conjugated nanoparticles over unconjugated nanoparticles. Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Budesonide; Cell Cycle; Cell Proliferation; Cells, Cultured; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Coumarins; Drug Delivery Systems; Excipients; Intubation, Intratracheal; Lactic Acid; Lung; Male; Microscopy, Confocal; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Wheat Germ Agglutinins	2008

Article

Year

Wheat germ agglutinin-conjugated nanoparticles for sustained cellular and lung delivery of budesonide.

Drug delivery, 2008, Volume: 15, Issue:2

The purpose of our studies was to assess in vitro nanoparticles cellular uptake and cellular budesonide levels after treatment of alveolar epithelial cell lines with wheat germ agglutinin (WGA)-conjugated budesonide nanoparticles and pharmacokinetic evaluation of drug after intratracheal instillation of nanoparticles in rats. Confocal microscopy was used to study the cellular uptake of nanoparticles, and the cellular and lung tissue drug levels were estimated by HPLC. Higher amount of fluorescence observed in the cells treated with WGA nanoparticles, higher and sustained cellular drug levels, and better bioavailability in lungs of WGA-conjugated nanoparticles indicate superiority of WGA-conjugated nanoparticles over unconjugated nanoparticles.

Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Budesonide; Cell Cycle; Cell Proliferation; Cells, Cultured; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Coumarins; Drug Delivery Systems; Excipients; Intubation, Intratracheal; Lactic Acid; Lung; Male; Microscopy, Confocal; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Wheat Germ Agglutinins

2008