Compounds > pteridines

pteridines and transforming growth factor beta

pteridines has been researched along with transforming growth factor beta in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.35)18.2507
2000's7 (30.43)29.6817
2010's15 (65.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blau, N; Kierat, L; Schaffner, A; Schoedon, G; Walter, R1
Bonniaud, P; Chakravarty, S; Damm, D; Dugar, S; Gauldie, J; Higgins, L; Kapoun, AM; Kolb, M; Margetts, PJ; Murphy, A; Protter, AA; Schroeder, JA1
Chakravarty, S; Damm, D; Dugar, S; Gaspar, NJ; Higgins, LS; Kapoun, AM; Lam, A; Liu, X; Liu, YW; Ma, JY; Munson, K; Murphy, A; O'young, G; Protter, AA; Quon, D; Rennard, SI; Tran, TT; Wang, Y; Wen, FQ1
Akhurst, RJ1
Chung, KF; Leung, SY; Medicherla, S; Niimi, A; Noble, A; Oates, T; Protter, AA; Williams, AS1
Chakravarty, S; Damm, DL; Gaspar, NJ; Henson, M; Higgins, LS; Kapoun, AM; Li, G; Li, L; Medicherla, S; Muiru, GT; Murphy, A; O'Young, G; Quon, D; Reddy, M; Wong, DH1
Bridgman, PG; Cameron, VA; Ellmers, LJ; Medicherla, S; Pilbrow, AP; Protter, AA; Richards, AM; Scott, NJ; Yandle, TG1
Abraham, DJ; Carulli, MT; Denton, CP; Khan, K; Lindahl, G; Ong, VH; Xu, S1
Klaassen, I; Schlingemann, RO; Van Geest, RJ; Van Noorden, CJ; Vogels, IM1
Barger, PM; Chancey, AL; Gao, F; Lavine, KJ; Mann, DL; Sivasubramanian, N; Tzeng, HP; Zhang, W; Zhou, Z1
Collette, NM; Genetos, DC; Keller, H; Leupin, O; Loots, GG; Murugesh, D1
Barnhart, M; Hartman, R; Lekic, T; Manaenko, A; Zhang, JH1
Abastabar, M; Akbari, A; Amanpour, S; Dehpour, AR; Faghihloo, E; Ghaffari, SH; Ghahremani, MH; Heidari, M; Karimi, A; Khoshzaban, A; Mobini, GR; Muhammadnejad, S; Shidfar, F1
Amadio, PC; An, KN; Gingery, A; Passe, SM; Yang, TH; Zhao, C1
Amiaud, J; Bougras, G; Chesneau, J; Heymann, D; Heymann, MF; Lamora, A; Le Deley, MC; Leduc, M; Redini, F; Stresing, V; Talbot, J; Taurelle, J; Verrecchia, F1
Chen, Y; Creighton, CJ; Dakhova, O; Dang, TD; Guo, D; Ittmann, MM; Rowley, DR; Shen, T; Yang, F; Zhang, Y1
Chirgwin, JM; Clines, GA; Fournier, PG; Guise, TA; Jiang, G; Juárez, P; Kim, HS; Liu, Y; Mohammad, KS; Niewolna, M; Peng, XH; Walton, HW; Wells, CD1
Abed Khojasteh, H; Akbari, A; Bolhassani, M; Fadakar, P; Ghassemi, F; Heidari, M; Mobini, GR; Mohebi, M1
Han, F; Jiang, M; Li, J; Liu, Y; Liu, Z; Luo, B; Shen, Z; Wang, J; Xu, K; Zhang, Z; Zhang, ZY1
Cordazzo, C; Dees, C; Distler, JH; Distler, O; Krasowska, D; Liang, R; Mallano, T; Michalska-Jakubus, M; Ramming, A; Schett, G; Šenolt, L; Šumová, B; Wohlfahrt, T; Zhang, Y1
Burghardt, I; Papa, E; Szabó, E; Ventura, E; Weiss, T; Weller, M1
Fang, B; Johnson, FM; Peng, S; Rao, X; Sambandam, V; Shen, L; Singh, R; Viswanath, P; Wang, J1
Chantry, AD; Down, JM; Evans, HR; Green, AC; Hudson, K; Lath, D; Lawson, MA; Owen, R; Paton-Hough, J; Reilly, GC; Walkley, B1

Reviews

1 review(s) available for pteridines and transforming growth factor beta

ArticleYear
Large- and small-molecule inhibitors of transforming growth factor-beta signaling.
    Current opinion in investigational drugs (London, England : 2000), 2006, Volume: 7, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Clinical Trials as Topic; Humans; Neoplasms; Oligonucleotides, Antisense; Patient Selection; Pteridines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2006

Other Studies

22 other study(ies) available for pteridines and transforming growth factor beta

ArticleYear
Effects of activating and deactivating cytokines on the functionally linked tetrahydrobiopterin. No pathways in vascular smooth muscle cells.
    Immunology letters, 1996, Dec-01, Volume: 54, Issue:1

    Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cytokines; Humans; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-4; Lipopolysaccharides; Muscle, Smooth, Vascular; Nitric Oxide; Pteridines; Pterins; Rats; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

1996
Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.
    American journal of respiratory and critical care medicine, 2005, Apr-15, Volume: 171, Issue:8

    Topics: Activin Receptors, Type I; Administration, Oral; Animals; Cells, Cultured; Down-Regulation; Female; Fibroblasts; Lung; Oligonucleotide Array Sequence Analysis; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pteridines; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation

2005
Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.
    Molecular pharmacology, 2006, Volume: 70, Issue:2

    Topics: Activin Receptors, Type I; Cell Differentiation; Cells, Cultured; Collagen; Connective Tissue Growth Factor; Cytoskeleton; Fibroblasts; Gene Expression Regulation; Humans; Immediate-Early Proteins; Inflammation; Intercellular Signaling Peptides and Proteins; Lung; MAP Kinase Signaling System; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pteridines; Pulmonary Fibrosis; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Wound Healing

2006
Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:2

    Topics: Acetylcholine; Activin Receptors, Type I; Animals; Asthma; Bromodeoxyuridine; Bronchi; Chronic Disease; Dose-Response Relationship, Drug; Female; Immunoglobulin E; Muscle, Smooth; Ovalbumin; Protein Serine-Threonine Kinases; Pteridines; Rats; Rats, Inbred BN; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta

2006
Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.
    Molecular pharmacology, 2007, Volume: 72, Issue:1

    Topics: Activin Receptors, Type I; Adenocarcinoma; Animals; Cell Line, Tumor; Cell Proliferation; Genes, myc; Humans; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Pancreatic Neoplasms; Protein Serine-Threonine Kinases; Pteridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Transplantation, Heterologous; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor C

2007
Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction.
    Endocrinology, 2008, Volume: 149, Issue:11

    Topics: Animals; Cardiomegaly; Down-Regulation; Drug Evaluation, Preclinical; Gene Expression Regulation; Heart; Kidney; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Pteridines; Receptors, Transforming Growth Factor beta; Renin; Renin-Angiotensin System; Transforming Growth Factor beta; Ventricular Remodeling

2008
Cross-talk between MCP-3 and TGFbeta promotes fibroblast collagen biosynthesis.
    Experimental cell research, 2009, Jan-15, Volume: 315, Issue:2

    Topics: Animals; Cells, Cultured; Chemokine CCL7; Collagen; Collagen Type I; Enzyme Inhibitors; Fibroblasts; Gene Expression; Mice; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pteridines; Recombinant Proteins; RNA, Small Interfering; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta

2009
Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:4

    Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Diabetic Retinopathy; Endothelium, Vascular; Fibronectins; Pericytes; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Pteridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Retinal Vessels; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Smad7 Protein; Transforming Growth Factor beta

2010
The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions.
    Circulation, 2011, Nov-08, Volume: 124, Issue:19

    Topics: Animals; Cell Communication; Endomyocardial Fibrosis; Fibroblasts; Gene Expression; Mast Cells; Mice; Mice, Transgenic; Myocarditis; Myocardium; Phenotype; Primary Cell Culture; Pteridines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2011
TGF-β regulates sclerostin expression via the ECR5 enhancer.
    Bone, 2012, Volume: 50, Issue:3

    Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Line; Enhancer Elements, Genetic; Genetic Markers; Male; Mice; Osteoblasts; Parathyroid Hormone; Pteridines; Rats; Signal Transduction; Transforming Growth Factor beta

2012
Inhibition of transforming growth factor-β attenuates brain injury and neurological deficits in a rat model of germinal matrix hemorrhage.
    Stroke, 2014, Volume: 45, Issue:3

    Topics: Adult; Animals; Atrophy; Blotting, Western; Brain Injuries; Cerebral Ventricles; Extracellular Matrix Proteins; Female; Glial Fibrillary Acidic Protein; Humans; Hydrocephalus; Immunohistochemistry; Intracranial Hemorrhages; Nervous System Diseases; Neurologic Examination; Pregnancy; Pteridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Survival; Transforming Growth Factor beta; Vitronectin; Weight Loss

2014
Evaluation of antitumor activity of a TGF-beta receptor I inhibitor (SD-208) on human colon adenocarcinoma.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2014, Jun-05, Volume: 22

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Female; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pteridines; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2014
TGF-β signaling regulates fibrotic expression and activity in carpal tunnel syndrome.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014, Volume: 32, Issue:11

    Topics: Adult; Biopsy; Cadaver; Carpal Tunnel Syndrome; Collagen Type I; Collagen Type III; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Middle Aged; Oligonucleotide Array Sequence Analysis; Pteridines; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta

2014
Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Oct-01, Volume: 20, Issue:19

    Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression; Heterografts; Humans; Lung Neoplasms; Mice; Osteoclasts; Osteosarcoma; Pteridines; Signal Transduction; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta; Tumor Burden

2014
Stromal TGF-β signaling induces AR activation in prostate cancer.
    Oncotarget, 2014, Nov-15, Volume: 5, Issue:21

    Topics: Androgens; Apoptosis; Benzamides; Blotting, Western; Bone Morphogenetic Protein 6; Cell Proliferation; Humans; Interleukin-6; Kallikreins; Male; Microarray Analysis; Nitriles; Phenylthiohydantoin; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Pteridines; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Signal Transduction; Stromal Cells; Transforming Growth Factor beta; Tumor Cells, Cultured

2014
The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone.
    Cancer cell, 2015, Jun-08, Volume: 27, Issue:6

    Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Gene Knockdown Techniques; Hep G2 Cells; Humans; Male; Membrane Proteins; Mice; Mice, Nude; Prostatic Neoplasms; Pteridines; Signal Transduction; Transforming Growth Factor beta

2015
Evaluation of SD-208, a TGF-β-RI Kinase Inhibitor, as an Anticancer Agent in Retinoblastoma.
    Acta medica Iranica, 2016, Volume: 54, Issue:6

    Topics: Cell Line, Tumor; Cell Proliferation; Child; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Pteridines; Real-Time Polymerase Chain Reaction; Retinal Neoplasms; Retinoblastoma; RNA, Neoplasm; Transforming Growth Factor beta

2016
Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 09-14, Volume: 36, Issue:37

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Disease Models, Animal; Docosahexaenoic Acids; Ectodysplasins; Enzyme Inhibitors; Forkhead Transcription Factors; Gene Expression Regulation; Macrophages; Male; Neuritis, Autoimmune, Experimental; Phagocytosis; Pteridines; Rats; Rats, Inbred Lew; Receptors, Lipoxin; Sciatic Nerve; T-Lymphocytes, Regulatory; Transforming Growth Factor beta

2016
The transcription factor GLI2 as a downstream mediator of transforming growth factor-β-induced fibroblast activation in SSc.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:4

    Topics: Adult; Aged; Anilides; Animals; Cells, Cultured; Collagen Type I; Connective Tissue Growth Factor; Female; Fibroblasts; Fibrosis; Gene Knockout Techniques; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Male; Mice; Mice, Knockout; Mice, Transgenic; Middle Aged; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Pteridines; Pulmonary Fibrosis; Pyridines; Pyrimidines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Recombinant Proteins; RNA, Messenger; Scleroderma, Systemic; Signal Transduction; Skin; Smad3 Protein; Smoothened Receptor; Transforming Growth Factor beta; Young Adult; Zinc Finger Protein Gli2

2017
Negative control of the HGF/c-MET pathway by TGF-β: a new look at the regulation of stemness in glioblastoma.
    Cell death & disease, 2017, 12-13, Volume: 8, Issue:12

    Topics: Antineoplastic Agents; Butadienes; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplastic Stem Cells; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pteridines; Pyrazoles; Pyridazines; Pyrimidines; Pyrroles; Quinolines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2017
Non-canonical cMet regulation by vimentin mediates Plk1 inhibitor-induced apoptosis.
    EMBO molecular medicine, 2019, Volume: 11, Issue:5

    Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; Drug Resistance, Neoplasm; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Humans; Integrin beta1; Lung Neoplasms; Mice, Nude; Phenotype; Phosphorylation; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Pteridines; Transforming Growth Factor beta; Vimentin; Xenograft Model Antitumor Assays

2019
TGFβ Inhibition Stimulates Collagen Maturation to Enhance Bone Repair and Fracture Resistance in a Murine Myeloma Model.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019, Volume: 34, Issue:12

    Topics: Alkaline Phosphatase; Animals; Bone Remodeling; Bortezomib; Cancellous Bone; Collagen; Disease Models, Animal; Female; Fractures, Bone; Green Fluorescent Proteins; Humans; Lenalidomide; Mesenchymal Stem Cells; Mice; Mice, SCID; Multiple Myeloma; Organ Size; Osteoblasts; Osteoclasts; Parathyroid Hormone-Related Protein; Pteridines; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Wound Healing; X-Ray Microtomography

2019