Compounds > pteridines

pteridines and thiophenes

pteridines has been researched along with thiophenes in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (84.62)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Dunoff, RY; Graboyes, H; Jaffe, G; Karash, CB; Pachter, IJ; Snader, K; Weinstock, J1
Bottegoni, G; Garuti, L; Roberti, M1
Yim, H1
Abbott, NJ; Bertone, P; Danovi, D; Elbatsh, AM; Ender, C; Engström, PG; Ferretti, P; Folarin, A; Gagrica, S; Georgian, A; Gogolok, S; Harvey, KJ; Paddison, PJ; Pollard, SM; Preston, JE; Smith, A; Stricker, SH; U, KP; Yu, D1
Bogado, RF; Brassesco, MS; de Oliveira, HF; Pezuk, JA; Tone, LG1
Shin, SB; Woo, SU; Yim, H1
Byers, LA; Diao, L; Ferrarotto, R; Gibbons, DL; Girard, L; Giri, U; Glisson, BS; Goonatilake, R; Heymach, JV; Johnson, FM; Li, L; Minna, J; Peng, DH; Peng, S; Tong, P; Wang, J; Wang, L; Wang, Y; Yoo, SY1
Althoff, K; Dreesmann, S; Eggert, A; Schramm, A; Schulte, JH; Schwermer, M; Steenpass, L; Temming, P1
Frederick, M; Johnson, FM; Kalu, NN; Li, L; Mazumdar, T; Myers, JN; Peng, S; Pickering, CR; Sambandam, V; Shen, L; Singh, R; Tong, P; Wang, J; Zhang, M1
Lee, YJ; Shin, SB; Woo, SU; Yim, H1
Brassesco, MS; Pezuk, JA; Roberto, GM; Salomão, KB; Scrideli, CA; Tone, LG1
Chou, TC; Huang, YT; Lin, JD; Lin, SF; Wong, RJ; Yeh, CN1
Jang, HR; Kim, CH; Shin, SB; Yim, H1

Reviews

2 review(s) available for pteridines and thiophenes

ArticleYear
Polo-like kinases inhibitors.
    Current medicinal chemistry, 2012, Volume: 19, Issue:23

    Topics: Binding, Competitive; Catalytic Domain; Cell Cycle Proteins; DNA Repair; Humans; Neoplasms; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Pyridines; Quinazolines; Thiophenes

2012
Current clinical trials with polo-like kinase 1 inhibitors in solid tumors.
    Anti-cancer drugs, 2013, Volume: 24, Issue:10

    Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Clinical Trials as Topic; Humans; Molecular Targeted Therapy; Neoplasms; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Thiophenes

2013

Other Studies

11 other study(ies) available for pteridines and thiophenes

ArticleYear
Pteridines. 8. Some 2,4,7-triamino-6-heteroarylpteridines.
    Journal of medicinal chemistry, 1968, Volume: 11, Issue:3

    Topics: Chromatography, Paper; Furans; Hydrogen-Ion Concentration; Imidazoles; Oxazoles; Pteridines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Spectrum Analysis; Thiazoles; Thiophenes; Triazoles; Ultraviolet Rays

1968
A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Indans; Mice; Mice, Knockout; Neoplastic Stem Cells; Neural Stem Cells; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Small Molecule Libraries; Swine; Thiophenes; Tumor Suppressor Protein p53

2013
BI 6727 and GSK461364 suppress growth and radiosensitize osteosarcoma cells, but show limited cytotoxic effects when combined with conventional treatments.
    Anti-cancer drugs, 2015, Volume: 26, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Bone Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; Osteosarcoma; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Radiation Tolerance; Radiation-Sensitizing Agents; Thiophenes

2015
Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain.
    Journal of cellular physiology, 2015, Volume: 230, Issue:12

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Benzimidazoles; Benzoates; Benzoquinones; Binding Sites; Catalytic Domain; Cell Cycle Proteins; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Drug Design; Female; G2 Phase Cell Cycle Checkpoints; HeLa Cells; Humans; Inhibitory Concentration 50; Mitosis; Molecular Targeted Therapy; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Pteridines; Quinones; S Phase Cell Cycle Checkpoints; Signal Transduction; Thiophenes; Time Factors; Uterine Cervical Neoplasms

2015
Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Apr-01, Volume: 22, Issue:7

    Topics: Animals; Apoptosis; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Chromosomal Instability; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Mice; Mutation; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pteridines; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays

2016
Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines.
    Clinical & experimental ophthalmology, 2017, Volume: 45, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Blotting, Western; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Cyclin B1; Cyclin-Dependent Kinases; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Phosphorylation; Polo-Like Kinase 1; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Real-Time Polymerase Chain Reaction; Retinal Neoplasms; Retinoblastoma; Thiophenes; Tumor Cells, Cultured

2017
Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.
    Cancer letters, 2017, 04-28, Volume: 392

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Checkpoint Kinase 2; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Genotype; Head and Neck Neoplasms; Humans; LIM Domain Proteins; Mice, Nude; Molecular Targeted Therapy; Mutation; Nuclear Proteins; Phenotype; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pteridines; Pyrazoles; Pyrimidines; Pyrimidinones; ras Proteins; RNA Interference; Signal Transduction; Smad4 Protein; Squamous Cell Carcinoma of Head and Neck; Thiophenes; Time Factors; Transfection; Tumor Burden; Urea; Xenograft Model Antitumor Assays

2017
Comparative Analysis of a FRET-based PLK1 Kinase Assay to Identify PLK1 inhibitors for Chemotherapy.
    Anticancer research, 2017, Volume: 37, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzimidazoles; Biological Assay; Biomarkers, Tumor; Cell Cycle Proteins; Drug Evaluation, Preclinical; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Genistein; Glutathione Transferase; Humans; Insecta; Peptides; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Radioisotopes; Thiophenes; Tumor Protein, Translationally-Controlled 1

2017
PLK1 Inhibition Radiosensitizes Breast Cancer Cells, but Shows Low Efficacy as Monotherapy or in Combination with other Cytotoxic Drugs.
    Anti-cancer agents in medicinal chemistry, 2018, Volume: 18, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Radiation-Sensitizing Agents; Thiophenes

2018
Targeting PLKs as a therapeutic approach to well-differentiated thyroid cancer.
    Endocrine-related cancer, 2019, Volume: 26, Issue:8

    Topics: Adenocarcinoma, Follicular; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Female; Humans; Mice; Mice, Nude; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Sorafenib; Thiophenes; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2019
Combination of Inhibitors of USP7 and PLK1 has a Strong Synergism against Paclitaxel Resistance.
    International journal of molecular sciences, 2020, Nov-16, Volume: 21, Issue:22

    Topics: A549 Cells; Cell Cycle Proteins; Drug Resistance, Neoplasm; Humans; Neoplasms; Paclitaxel; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Thiophenes; Ubiquitin-Specific Peptidase 7

2020