pteridines and sepiapterin

pteridines has been researched along with sepiapterin in 92 studies

Research

Studies (92)

TimeframeStudies, this research(%)All Research%
pre-199024 (26.09)18.7374
1990's35 (38.04)18.2507
2000's32 (34.78)29.6817
2010's1 (1.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bettoni, O; Bieri, J; Curtius, HC; Niederwieser, A; Schaub, J; Schircks, B; Viscontini, M1
Gross, SS; Levi, R1
Bult, H; Herman, AG; Jorens, PG; van Overveld, FJ; Vermeire, PA1
Nakagoshi, M; Negishi, S1
Nakagoshi, M; Negishi, S; Takikawa, S; Tsusué, M1
Blaskovics, M; Blau, N; Curtius, HC; Giudici, T; Kierat, L1
Bigham, EC; Duch, DS; Edelstein, MP; Smith, GK1
Gross, SS; Jaffe, EA; Kilbourn, RG; Levi, R1
Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G1
Bacher, A; Kerler, F; Schmid, C; Ziegler, I1
Perez-Polo, JR; Shen, RS; Zhang, YX1
Jacobson, KB; Manos, RE1
Abou-Donia, MM; Nichol, CA; Viveros, OH; Wilson, SP; Zimmerman, TP1
Bowers, SW; Duch, DS1
Smith, GK1
Alam, A; Shen, RS; Zhang, YX1
Katoh, S; Sueoka, T2
Boudha, A; Dhondt, JL; Farriaux, JP; Largillière, C; Leeming, RJ; Ringel, J; Roger, MM1
Akino, M; Katoh, S; Masada, M; Sueoka, T1
Cotlier, E; Rao, GN1
Brown, GM; Primus, JP; Switchenko, AC1
Chao, JY; Duch, DS; Edelstein, MP; Lee, CL; Nichol, CA1
Andondonskaja-Renz, B; Zeitler, HJ1
Nichol, CA; Smith, GK1
Fukushima, T1
Goto, M; Otsuka, H; Sugiura, K1
Akino, M; Doi, M; Hagi, Y; Shiota, T; Tanaka, K1
Curtius, HC; Leupold, D; Niederwieser, A; Wang, M1
Kapatos, G; Katoh, S; Kaufman, S1
Dorsett, D; Flanagan, JM; Jacobson, KB1
Curtius, HC; Ghisla, S; Häusermann, M; Niederwieser, A1
DeLustro, B; Eugui, E; Natsumeda, Y; Senda, M1
Gross, SS; Hattori, Y; Levi, R; Madera, A; Park, KH; Vane, J1
Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G1
Koshimura, K; Miwa, S; Watanabe, Y1
Mühl, H; Pfeilschifter, J1
Bachus, KE; Dittman, WA; Mason, SN; McDonald, B; Misukonis, MA; Sauls, DL; Shami, PJ; Smith, GK; Weinberg, JB; Wood, ER1
Fuchs, D; Hausen, A; Reibnegger, G; Schmidt, K; Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G1
Drögemüller, A; Mülsch, A; Schmitz, W; Scholz, H; Stein, B1
Amoah-Apraku, B; Guzman, NJ; Ingelfinger, JR; Tang, SS1
Kaufman, S; Ribeiro, P1
Koshimura, K; Miwa, S; Ohue, T; Watanabe, Y1
Billiar, TR; Loftus, M; Robbins, PD; Stuehr, DJ; Tzeng, E1
Cañada, FJ; Lamas, S; Pérez-Sala, D; Saura, M1
Katusic, ZS; Milstien, S; Tsutsui, M1
Chilian, WM; DeFily, DV; Mitchell, M; Tiefenbacher, CP1
Blau, N; Kierat, L; Schaffner, A; Schoedon, G; Walter, R1
Ito, K; Kawanishi, S1
Garver, RI; Haddad, IY; Hong, J; Matalon, S; Sorscher, EJ; Tzeng, E1
Ishii, M; Kuroiwa, Y; Momose, K; Shimizu, S; Yamamoto, T1
Díaz-Cazorla, M; Jiménez, W; Lamas, S; Pérez-Sala, D; Ros, J1
Fitzpatrick, LA; Katusic, ZS; Kullo, IJ; Milstien, S; O'Brien, T; Pompili, VJ; Schwartz, RS; Tsutsui, M1
Linscheid, P; Schaffner, A; Schoedon, G1
Arai, M; Kondo, A; Mogi, M; Nagatsu, T; Togari, A1
Ishii, M; Momose, K; Shimizu, S; Yamamoto, T2
Ishii, M; Kawakami, Y; Momose, K; Shimizu, S; Yamamoto, T1
Ishii, M; Kiuchi, Y; Nawata, S; Shimizu, S; Yamamoto, T1
Huang, A; Keaney, JF; Venema, RC; Vita, JA1
Kang, UJ; Kowlessur, D; Lei, XG; Milstien, S; Nakamura, K; Wiatr, T; Wright, DA1
Hatakeyama, K; Kelly, KA; Marinos, RS; Martinez-Zaguilan, R; Meininger, CJ; Rojas, JD; Wu, G1
Heller, R; Mayer, B; Schellenberg, B; Unbehaun, A; Werner, ER; Werner-Felmayer, G1
Amann, K; Bleeke, T; Kübler, W; Tiefenbacher, CP; Vahl, C; Vogt, A1
Dittrich, P; Gibraeil, HD; Mayer, B; Saleh, S1
Assreuy, J; Guimarães, C; Linden, R1
Bai, Y; Sagai, M; Suzuki, AK1
Hiraku, Y; Kawanishi, S1
Freeman, BA; Fukai, T; Harrison, DG; Kurz, S; Laursen, JB; McCann, L; Somers, M; Tarpey, M; Warnholtz, A1
Tiefenbacher, CP1
Dorrance, AM; Johns, DG; Tramontini, NL; Webb, RC1
Cap, A; Leopold, JA; Loscalzo, J; Scribner, AW; Stanton, RC1
Bahrami, S; Heller, R; Werner, ER; Werner-Felmayer, G1
Fujimoto, K; Katoh, S; Takahashi, SY1
Jesuthasan, S; Le Guyader, S1
Blau, N; Penzien, JM; Redweik, U; Thöny, B; Trippe, H; Zorzi, G1
Beazley, WD; Rokos, H; Schallreuter, KU1
Anderson, TJ; Hyndman, ME; Parsons, HG; Rosenfeld, RJ; Verma, S1
Choi, YK; Kang, JY; Park, YS; Woo, HJ1
Gröne, HJ; Huisman, A; Joles, JA; Martasek, P; Rabelink, TJ; van Faassen, EE; van Zonneveld, AJ; Vanin, AF; Vos, I1
Gramsbergen, JB; Kornblit, B; Møller Dall, A; Sandberg, M; Zimmer, J1
Cunningham, JM; Stickings, P1
Choi, YK; Hwang, YK; Kang, JY; Kim, CG; Kim, YJ; Park, YS; Woo, HJ1
Tarpey, MM1
Duquaine, D; Kalyanaraman, B; Rajagopalan, S; Vásquez-Vivar, J; Whitsett, J1
Habecker, BA; Klein, MG; Li, W; Sundgren, NC; Woodward, WR1
Carruthers, R; Mangan, R; Tomic-Carruthers, N1
Gramsbergen, JB; Hesslinger, C; Jansen, P; Madsen, JT; Meyer, M; Zimmer, J1
Campbell, S; Gallery, ED; Rowe, J1
Ziegler, I1
BAGNARA, JT; OBIKA, M1
Martínez, A; Vargas, R1

Reviews

5 review(s) available for pteridines and sepiapterin

ArticleYear
Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Amino Acid Oxidoreductases; Animals; Aorta; Biopterins; Enzyme Induction; Gene Expression; GTP Cyclohydrolase; Kinetics; Lipopolysaccharides; Models, Biological; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Rats; RNA, Messenger

1993
Modulation of nitric oxide synthase activity in intact cells by intracellular tetrahydrobiopterin levels.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Cells, Cultured; Cytokines; Endothelium, Vascular; Enzyme Induction; Fibroblasts; Humans; Mice; Models, Biological; Nitric Oxide Synthase; Pteridines; Pterins; Umbilical Veins

1993
Sequence-specific DNA damage induced by UVA radiation in the presence of endogenous and exogenous photosensitizers.
    Current problems in dermatology, 2001, Volume: 29

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Infective Agents; Carcinogens; Cell Transformation, Neoplastic; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; Fluoroquinolones; Guanine; Humans; Models, Chemical; Mutagenesis; Nalidixic Acid; Neoplasms, Radiation-Induced; Oxidation-Reduction; Oxygen; Pteridines; Pterins; Quinolones; Radiation-Sensitizing Agents; Singlet Oxygen; Skin Neoplasms; Sunlight; Superoxides; Ultraviolet Rays

2001
Sepiapterin treatment in atherosclerosis.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Oct-01, Volume: 22, Issue:10

    Topics: Animals; Arteriosclerosis; Biopterins; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pteridines; Pterins

2002
The pteridine pathway in zebrafish: regulation and specification during the determination of neural crest cell-fate.
    Pigment cell research, 2003, Volume: 16, Issue:3

    Topics: Animals; Biopterins; Cell Lineage; Gene Expression Regulation, Developmental; GTP Cyclohydrolase; Guanosine Triphosphate; Melanophores; Models, Biological; Models, Chemical; Mutation; Neural Crest; Neurons; Phenotype; Pigments, Biological; Pteridines; Pterins; Signal Transduction; Time Factors; Tyrosine; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthopterin; Zebrafish

2003

Trials

1 trial(s) available for pteridines and sepiapterin

ArticleYear
Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid.
    Biochemical and biophysical research communications, 2002, Apr-12, Volume: 292, Issue:4

    Topics: Biopterins; Catalase; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Epidermis; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxidative Stress; Oxygen; Photochemistry; Pteridines; Pterins; Ultraviolet Rays; Vitiligo

2002

Other Studies

86 other study(ies) available for pteridines and sepiapterin

ArticleYear
Atypical phenylketonuria caused by 7, 8-dihydrobiopterin synthetase deficiency.
    Lancet (London, England), 1979, Jan-20, Volume: 1, Issue:8108

    Topics: Alcohol Oxidoreductases; Biopterins; Child, Preschool; Female; Guanosine Triphosphate; Humans; Phenylalanine; Phenylketonurias; Pteridines; Pterins

1979
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
    The Journal of biological chemistry, 1992, Dec-25, Volume: 267, Issue:36

    Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Biopterins; Cells, Cultured; Cytosol; Hypoxanthines; Interferon-gamma; Kinetics; Lipopolysaccharides; Male; Methotrexate; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen Consumption; Pteridines; Pterins; Rats; Rats, Inbred F344; Recombinant Proteins

1992
Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Citrulline; Hypoxanthines; Interferon-gamma; Macrophages, Alveolar; Male; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Rats; Rats, Wistar; Recombinant Proteins

1992
Morphological and biochemical characterization of the cream markings in the integument of the female isopod, Armadillidium vulgare.
    Pigment cell research, 1992, Volume: 5, Issue:5 Pt 1

    Topics: Animals; Crustacea; Epidermis; Female; Pigments, Biological; Pteridines; Pterins

1992
Pteridines in the yellow-colored chromatophores of the isopod, Armadillidium vulgare.
    Biological chemistry Hoppe-Seyler, 1992, Volume: 373, Issue:12

    Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; Chromatophores; Crustacea; Female; Male; Microscopy, Electron; Pigmentation; Pteridines; Pterins; Sex Characteristics; Spectrometry, Fluorescence; Uric Acid

1992
Hyperphenylalaninaemia presumably due to carbinolamine dehydratase deficiency: loading tests with pterin derivatives.
    Journal of inherited metabolic disease, 1992, Volume: 15, Issue:3

    Topics: Biopterins; Female; Humans; Hydro-Lyases; Infant, Newborn; Kinetics; Phenylalanine; Pteridines; Pterins

1992
New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines.
    The Journal of biological chemistry, 1992, Mar-15, Volume: 267, Issue:8

    Topics: Alcohol Oxidoreductases; Biopterins; Cell Division; Cell Line; Humans; Kinetics; Models, Molecular; Molecular Conformation; Molecular Structure; Pteridines; Pterins; Pyrimidines; Serotonin; Structure-Activity Relationship

1992
Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages.
    Biochemical and biophysical research communications, 1991, Aug-15, Volume: 178, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Calmodulin; Cells, Cultured; Cycloheximide; Cytokines; Endothelium, Vascular; Interferon-gamma; Isoenzymes; Kinetics; Macrophage Activation; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Recombinant Proteins; Tumor Necrosis Factor-alpha

1991
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.
    The Journal of experimental medicine, 1990, Dec-01, Volume: 172, Issue:6

    Topics: Animals; Biopterins; Cells, Cultured; Cytokines; Fibroblasts; Interferon-gamma; Interleukin-1; Kinetics; Methotrexate; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Pteridines; Pterins; Recombinant Proteins; Skin; Sugar Acids; Tumor Necrosis Factor-alpha

1990
Synthesis of tetrahydrobiopterin in Friend erythroleukemia cells and its modulator effect on cell proliferation.
    Experimental cell research, 1990, Volume: 189, Issue:2

    Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cell Division; Clone Cells; Dimethyl Sulfoxide; DNA Replication; Enzyme Induction; GTP Cyclohydrolase; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phenylalanine Hydroxylase; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Tumor Cells, Cultured

1990
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
    Journal of enzyme inhibition, 1989, Volume: 3, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animals; Biopterins; Cell Line; Colforsin; Cycloheximide; Dihydropteridine Reductase; GTP Cyclohydrolase; Isoenzymes; Kinetics; Pheochromocytoma; Pteridines; Pterins; Rats; Reserpine; Theophylline

1989
Effects of sepiapterin and 6-acetyldihydrohomopterin on the guanosine triphosphate cyclohydrolase I of mouse, rat and the fruit-fly Drosophila.
    The Biochemical journal, 1989, May-15, Volume: 260, Issue:1

    Topics: Aminohydrolases; Animals; Azepines; Drosophila; GTP Cyclohydrolase; Liver; Mice; Mice, Mutant Strains; Pteridines; Pterins; Rats; Rats, Inbred Strains

1989
Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells.
    Journal of neurochemistry, 1986, Volume: 46, Issue:4

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Medulla; Aminohydrolases; Animals; Biopterins; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cyclic AMP; GTP Cyclohydrolase; Pteridines; Pterins; Serotonin; Tyrosine; Tyrosine 3-Monooxygenase

1986
In vivo measurement of dihydrofolate reductase and its inhibition by antifolates.
    Analytical biochemistry, 1988, Volume: 172, Issue:1

    Topics: Animals; Biopterins; Brain; Folic Acid Antagonists; Injections, Intraventricular; Liver; Male; Methotrexate; Mice; Pteridines; Pterins; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase

1988
On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin.
    Archives of biochemistry and biophysics, 1987, Volume: 255, Issue:2

    Topics: Alcohol Oxidoreductases; Animals; Antigen-Antibody Complex; Biopterins; Erythrocytes; Kinetics; Male; Molecular Weight; Pteridines; Pterins; Rats; Substrate Specificity; Tissue Distribution

1987
Inhibition of GTP cyclohydrolase I by pterins.
    Biochimica et biophysica acta, 1988, Apr-14, Volume: 965, Issue:1

    Topics: Aminohydrolases; Animals; Biopterins; Folic Acid; GTP Cyclohydrolase; Kinetics; Liver; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Rats; Xanthopterin

1988
[GTP cyclohydrolase activity in rat liver].
    Josai Shika Daigaku kiyo. The Bulletin of the Josai Dental University, 1985, Volume: 14, Issue:2-3

    Topics: Aminohydrolases; Animals; Biopterins; Carbon Radioisotopes; GTP Cyclohydrolase; Liver; Male; Pteridines; Pterins; Rats; Rats, Inbred Strains

1985
Neonatal hyperphenylalaninemia presumably caused by guanosine triphosphate-cyclohydrolase deficiency.
    The Journal of pediatrics, 1985, Volume: 106, Issue:6

    Topics: Aminohydrolases; Biopterins; GTP Cyclohydrolase; Humans; Infant, Newborn; Leukocyte Count; Liver; Male; Neopterin; Phenylalanine; Pteridines; Pterins; T-Lymphocytes

1985
Dyspropterin, an intermediate formed from dihydroneopterin triphosphate in the biosynthetic pathway of tetrahydrobiopterin.
    Biochimica et biophysica acta, 1985, Jun-18, Volume: 840, Issue:2

    Topics: Alcohol Oxidoreductases; Biopterins; Catalysis; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydropteridine Reductase; Hydroxylation; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Spectrophotometry, Ultraviolet

1985
Biosynthesis of neopterin, sepiapterin, and biopterin in rat and human ocular tissues.
    Investigative ophthalmology & visual science, 1985, Volume: 26, Issue:5

    Topics: Animals; Biopterins; Ciliary Body; Eye; Humans; Iris; Lens, Crystalline; Neopterin; Pteridines; Pterins; Rats; Retina

1985
Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity.
    Biochemical and biophysical research communications, 1984, Feb-14, Volume: 118, Issue:3

    Topics: Acetoin; Alcohol Oxidoreductases; Animals; Biopterins; Diacetyl; Erythrocytes; Gramicidin; Ketones; Kinetics; NADP; Oxidation-Reduction; Pteridines; Pterins; Rats; Spectrophotometry; Substrate Specificity

1984
Intermediates in the enzymic synthesis of tetrahydrobiopterin in Drosophila melanogaster.
    Biochemical and biophysical research communications, 1984, May-16, Volume: 120, Issue:3

    Topics: Animals; Biopterins; Biotransformation; Catalysis; Drosophila melanogaster; Edetic Acid; Magnesium; NADP; Neopterin; Pteridines; Pterins

1984
Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:6

    Topics: Adrenal Medulla; Animals; Biopterins; Brain; Cattle; Cells, Cultured; Cricetinae; Guanosine Triphosphate; Methotrexate; Mice; Pteridines; Pterins; Rats

1983
Separation of pteridines from blood cells and plasma by reverse-phase high-performance liquid chromatography.
    Analytical biochemistry, 1983, Volume: 133, Issue:1

    Topics: Animals; Blood Cells; Bone Marrow; Chromatography, High Pressure Liquid; Dogs; Humans; Plasma; Pteridines; Pterins; Temperature

1983
Tetrahydrobiopterin is synthesized by separate pathways from dihydroneopterin triphosphate and from sepiapterin in adrenal medulla preparations.
    Archives of biochemistry and biophysics, 1983, Volume: 227, Issue:1

    Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chemical Phenomena; Chemistry; Guanosine Triphosphate; Methotrexate; Neopterin; Pteridines; Pterins

1983
Isolation and preparation of pterins from biological materials.
    Methods in enzymology, 1980, Volume: 66

    Topics: Animals; Anura; Biopterins; Chromatography, Ion Exchange; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Rana catesbeiana; Skin

1980
Biosynthesis of biopterin in Ascaris lumbricoides suum.
    Biochimica et biophysica acta, 1980, Apr-17, Volume: 629, Issue:1

    Topics: Alcohol Oxidoreductases; Animals; Ascaris; Biopterins; Body Fluids; Chromatography, DEAE-Cellulose; Chromatography, Gel; Female; Guanosine Triphosphate; Multienzyme Complexes; Muscles; Pteridines; Pterins

1980
The enzymatic synthesis of sepiapterin by chicken kidney preparations.
    The Journal of biological chemistry, 1981, Mar-25, Volume: 256, Issue:6

    Topics: Alcohol Oxidoreductases; Animals; Chickens; Kidney; Kinetics; Multienzyme Complexes; Pteridines; Pterins; Spectrophotometry; Temperature

1981
Atypical phenylketonuria with defective biopterin metabolism. Monotherapy with tetrahydrobiopterin or sepiapterin, screening and study of biosynthesis in man.
    European journal of pediatrics, 1982, Volume: 138, Issue:2

    Topics: Biopterins; Child, Preschool; Female; Humans; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins; Serotonin

1982
Biosynthesis of biopterin by rat brain.
    Journal of neurochemistry, 1982, Volume: 39, Issue:4

    Topics: Animals; Biopterins; Brain; Chromatography, High Pressure Liquid; Corpus Striatum; Guanosine Triphosphate; Half-Life; Injections, Intraventricular; Pteridines; Pterins; Rats; Rats, Inbred Strains

1982
Biosynthesis, nonenzymatic synthesis, and purification of the intermediate in synthesis of sepiapterin in Drosophila.
    Biochemistry, 1982, Aug-03, Volume: 21, Issue:16

    Topics: Drosophila; Hydrogen-Ion Concentration; Magnesium; NADP; Neopterin; Pteridines; Pterins

1982
New aspects in biopterin biosynthesis in man.
    FEBS letters, 1981, Aug-31, Volume: 131, Issue:2

    Topics: Animals; Biopterins; Humans; Kidney; Liver; Male; Pteridines; Pterins; Rats

1981
Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
    Transplantation, 1995, Nov-27, Volume: 60, Issue:10

    Topics: Animals; Cells, Cultured; Cytokines; Endothelium, Vascular; Guanosine; Immunosuppressive Agents; IMP Dehydrogenase; Mice; Mycophenolic Acid; Nitric Oxide; Pteridines; Pterins; Rats

1995
Dopamine-releasing action of 6R-L-erythro-tetrahydrobiopterin: analysis of its action site using sepiapterin.
    Journal of neurochemistry, 1994, Volume: 63, Issue:2

    Topics: alpha-Methyltyrosine; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Biopterins; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Isomerism; Kinetics; Male; Methyltyrosines; Microdialysis; Nitric Oxide Synthase; Pteridines; Pterins; Rats; Rats, Wistar; Time Factors; Tyrosine 3-Monooxygenase

1994
Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells.
    Kidney international, 1994, Volume: 46, Issue:5

    Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Cells, Cultured; Dose-Response Relationship, Drug; Glomerular Mesangium; GTP Cyclohydrolase; Guanosine Triphosphate; Hypoxanthines; Interleukin-1; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Rats; Recombinant Proteins

1994
Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages.
    Blood, 1995, Aug-01, Volume: 86, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Base Sequence; Biopterins; Cell Line; DNA Primers; Enzyme Induction; Gene Expression; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Monocytes; Nitrates; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; RNA, Messenger

1995
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.
    The Journal of biological chemistry, 1993, Jan-25, Volume: 268, Issue:3

    Topics: Amino Acid Oxidoreductases; Biopterins; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypoxanthines; Interferon-gamma; Lipopolysaccharides; Neopterin; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Tumor Necrosis Factor-alpha; Umbilical Veins

1993
Ca(++)-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular cardiomyocytes.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2

    Topics: Amino Acid Oxidoreductases; Animals; Calcium; Carbachol; Cyclic GMP; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Methylene Blue; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Pertussis Toxin; Pteridines; Pterins; Virulence Factors, Bordetella

1993
Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules.
    Journal of the American Society of Nephrology : JASN, 1995, Volume: 5, Issue:8

    Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; GTP Cyclohydrolase; Hypoxanthines; Kidney Tubules, Proximal; Methotrexate; Mice; Nitric Oxide; Osmolar Concentration; Pteridines; Pterins

1995
The effect of tetrahydrobiopterin on the in situ phosphorylation of tyrosine hydroxylase in rat striatal synaptosomes.
    Neurochemical research, 1994, Volume: 19, Issue:5

    Topics: Animals; Biopterins; Bucladesine; Corpus Striatum; Ethers, Cyclic; Male; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Protein Phosphatase 2; Pteridines; Pterins; Rats; Rats, Sprague-Dawley; Synaptosomes; Tyrosine 3-Monooxygenase

1994
6R-L-erythro-5,6,7,8-tetrahydrobiopterin: a regulator of neurotransmitter release.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Hippocampus; Infusions, Parenteral; Kinetics; Male; Methyltyrosines; Microdialysis; Pteridines; Pterins; Rats; Rats, Wistar; Reserpine; Stereoisomerism

1993
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Dec-05, Volume: 92, Issue:25

    Topics: 3T3 Cells; Animals; Biopterins; Blotting, Northern; Blotting, Western; Cytosol; Dose-Response Relationship, Drug; Enzyme Induction; Genetic Engineering; Genetic Vectors; Humans; Mice; Nitric Oxide Synthase; Nitrites; Protein Conformation; Pteridines; Pterins; Recombinant Proteins; Retroviridae

1995
Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells.
    The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24

    Topics: Arginine; Biopterins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Sugar Acids; Transcription, Genetic; Tumor Necrosis Factor-alpha

1996
Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries.
    Circulation research, 1996, Volume: 79, Issue:2

    Topics: Animals; Anions; Biopterins; Calcium; Cerebral Arteries; Culture Media; Cyclic GMP; Dogs; Endothelium, Vascular; In Vitro Techniques; Pteridines; Pterins; Superoxides; Vasodilation

1996
Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin.
    Circulation, 1996, Sep-15, Volume: 94, Issue:6

    Topics: Animals; Biopterins; Endothelium, Vascular; Enzyme Inhibitors; Hemodynamics; Hypoxanthines; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Pteridines; Pterins; Reference Values; Swine; Vasodilation

1996
Effects of activating and deactivating cytokines on the functionally linked tetrahydrobiopterin. No pathways in vascular smooth muscle cells.
    Immunology letters, 1996, Dec-01, Volume: 54, Issue:1

    Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cytokines; Humans; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-4; Lipopolysaccharides; Muscle, Smooth, Vascular; Nitric Oxide; Pteridines; Pterins; Rats; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

1996
Photoinduced hydroxylation of deoxyguanosine in DNA by pterins: sequence specificity and mechanism.
    Biochemistry, 1997, Feb-18, Volume: 36, Issue:7

    Topics: Base Sequence; Deoxyguanine Nucleotides; Deoxyguanosine; Distamycins; DNA Damage; Hydroxylation; Magnesium Chloride; Photochemistry; Pteridines; Pterins; Spectrometry, Fluorescence; Spermine; Ultraviolet Rays

1997
Modulation of adenovirus-mediated gene transfer by nitric oxide.
    American journal of respiratory cell and molecular biology, 1997, Volume: 16, Issue:5

    Topics: 3T3 Cells; Adenoviruses, Human; Animals; Antioxidants; beta-Galactosidase; Biopterins; Cell Survival; Cyclic GMP; Enzyme Inhibitors; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Humans; Luciferases; Lung; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Pteridines; Pterins; Transfection

1997
Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content.
    Life sciences, 1997, Volume: 61, Issue:7

    Topics: Animals; Biopterins; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Hypoxanthines; Nitric Oxide Synthase; Oxidative Stress; Pteridines; Pterins; Superoxides

1997
Tetrahydrobiopterin modulates cyclooxygenase-2 expression in human mesangial cells.
    Biochemical and biophysical research communications, 1997, Dec-08, Volume: 241, Issue:1

    Topics: Biopterins; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Methotrexate; NG-Nitroarginine Methyl Ester; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Pteridines; Pterins; Quinoxalines; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha

1997
Expression and function of recombinant endothelial NO synthase in coronary artery smooth muscle cells.
    Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:11

    Topics: Adenoviridae; Animals; Biopterins; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Cyclic GMP; DNA Replication; Enzyme Induction; Genes, Reporter; Genetic Vectors; GTP Cyclohydrolase; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Recombinant Fusion Proteins; Superoxide Dismutase; Swine; Transfection

1997
Modulation of inducible nitric oxide synthase mRNA stability by tetrahydrobiopterin in vascular smooth muscle cells.
    Biochemical and biophysical research communications, 1998, Feb-04, Volume: 243, Issue:1

    Topics: Animals; Base Sequence; Biopterins; Cells, Cultured; Dicumarol; DNA Primers; Drug Stability; Gene Expression Regulation, Enzymologic; Kinetics; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Pteridines; Pterins; Rats; RNA, Messenger

1998
Coexpression of GTP cyclohydrolase I and inducible nitric oxide synthase mRNAs in mouse osteoblastic cells activated by proinflammatory cytokines.
    FEBS letters, 1998, May-29, Volume: 428, Issue:3

    Topics: 3T3 Cells; Animals; Apoptosis; Biopterins; Cell Nucleus; Cell Survival; Curcumin; Cytokines; DNA Fragmentation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Hypoxanthines; Interferon-gamma; Interleukin-1; Kinetics; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoblasts; Penicillamine; Proline; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Thiocarbamates; Transcription Factor AP-1; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha

1998
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.
    Pharmacology & toxicology, 1998, Volume: 82, Issue:6

    Topics: Animals; Arginine; Biopterins; Cattle; Cells, Cultured; Endothelium, Vascular; Hydrogen Peroxide; Ionomycin; omega-N-Methylarginine; Pteridines; Pterins; Rats; Serotonin

1998
Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death.
    Life sciences, 1998, Volume: 63, Issue:18

    Topics: Animals; Aorta, Thoracic; Biopterins; Cattle; Cell Death; Cytokines; Endothelium, Vascular; Enzyme Induction; L-Lactate Dehydrogenase; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penicillamine; Pteridines; Pterins; S-Nitroso-N-Acetylpenicillamine; Serotonin

1998
SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin.
    Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:2

    Topics: Animals; Antioxidants; Aorta; Benzoates; Biopterins; Catalase; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Iron Chelating Agents; L-Lactate Dehydrogenase; Molsidomine; Nitric Oxide; Plant Extracts; Pteridines; Pterins; Reactive Oxygen Species; Superoxide Dismutase; Trypan Blue

1999
Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats: protective effect of tetrahydrobiopterin.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:1

    Topics: Animals; Antioxidants; Biopterins; Male; Nitric Oxide; Pteridines; Pterins; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Stomach

2000
Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin.
    The Journal of biological chemistry, 2000, Jun-09, Volume: 275, Issue:23

    Topics: Animals; Aorta; Arginine; Ascorbic Acid; Atrial Natriuretic Factor; Biopterins; Calcimycin; Cattle; Cell Line; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; Spodoptera; Swine; Transfection

2000
Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin.
    Journal of neurochemistry, 2000, Volume: 74, Issue:6

    Topics: Animals; Antioxidants; Biopterins; Buthionine Sulfoximine; Cell Survival; Dopamine; Enzyme Inhibitors; Female; Glutathione; Glutathione Peroxidase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Parkinson Disease; Pregnancy; Pteridines; Pterins; Pyrazoles; Rats; Rats, Sprague-Dawley; tert-Butylhydroperoxide

2000
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.
    The Biochemical journal, 2000, Jul-01, Volume: 349, Issue:Pt 1

    Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Chromatography, High Pressure Liquid; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Immunoblotting; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Isoforms; Pteridines; Pterins; Rats; Rats, Mutant Strains

2000
L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin.
    The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1

    Topics: Ascorbic Acid; Biopterins; Cells, Cultured; Citrulline; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; GTP Cyclohydrolase; Humans; Hypoxanthines; Nitric Oxide; Nitric Oxide Synthase; Phosphorus-Oxygen Lyases; Pteridines; Pterins; RNA, Messenger; Solutions; Umbilical Cord

2001
Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis.
    Circulation, 2000, Oct-31, Volume: 102, Issue:18

    Topics: Acetylcholine; Animals; Arteriosclerosis; Atrial Appendage; Biopterins; Cholesterol; Coronary Vessels; Diet, Atherogenic; Dose-Response Relationship, Drug; Endothelium, Vascular; Histamine; Humans; In Vitro Techniques; Nitroprusside; Pteridines; Pterins; Serotonin; Substance P; Swine, Miniature; Vascular Resistance; Vasoconstriction; Vasodilation; Vasodilator Agents

2000
Inhibition of endotoxin-induced vascular hyporeactivity by 4-amino-tetrahydrobiopterin.
    British journal of pharmacology, 2000, Volume: 131, Issue:8

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Biopterins; Bradykinin; Calcimycin; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Endotoxins; Enzyme Inhibitors; Hydrazines; In Vitro Techniques; Lipopolysaccharides; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Nitrogen Oxides; Norepinephrine; Pteridines; Pterins; Pulmonary Artery; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

2000
Paracrine neuroprotective effect of nitric oxide in the developing retina.
    Journal of neurochemistry, 2001, Volume: 76, Issue:4

    Topics: Animals; Animals, Newborn; Anisomycin; Arginine; Biopterins; Cell Death; Cells, Cultured; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; NADPH Dehydrogenase; Neuroprotective Agents; Nitric Oxide; Paracrine Communication; Penicillamine; Pteridines; Pterins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine

2001
The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species.
    Free radical biology & medicine, 2001, Mar-01, Volume: 30, Issue:5

    Topics: Antioxidants; Biopterins; Catalase; Cell Division; Cell Line; Cell Survival; Endothelium, Vascular; Free Radical Scavengers; Humans; In Vitro Techniques; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Pulmonary Artery; Reactive Oxygen Species; Superoxide Dismutase; Vehicle Emissions

2001
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.
    Circulation, 2001, Mar-06, Volume: 103, Issue:9

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Apolipoproteins E; Biopterins; Calcimycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Ionophores; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroglycerin; Pteridines; Pterins; Superoxides; Vasodilation; Vasodilator Agents

2001
Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6

    Topics: Animals; Arginine; Biopterins; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Vessels; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Humans; Hypercholesterolemia; In Vitro Techniques; Infusions, Intra-Arterial; Ionophores; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pteridines; Pterins; Reactive Oxygen Species; Species Specificity; Substance P; Swine; Vasoconstrictor Agents; Vasodilator Agents

2001
Glucocorticoids inhibit tetrahydrobiopterin-dependent endothelial function.
    Experimental biology and medicine (Maywood, N.J.), 2001, Volume: 226, Issue:1

    Topics: Animals; Aorta, Thoracic; Biopterins; Dexamethasone; Endothelium, Vascular; Glucocorticoids; GTP Cyclohydrolase; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Phenylephrine; Pteridines; Pterins; Rats; Rats, Wistar; Vasoconstriction

2001
Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:10

    Topics: Animals; Aorta; Cattle; Cyclic GMP; Dehydroepiandrosterone; Endothelium, Vascular; Enzyme Inhibitors; Glucosephosphate Dehydrogenase; Hydrogen Peroxide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oligonucleotides, Antisense; Oxidative Stress; Pteridines; Pterins; Reactive Oxygen Species; Transfection

2001
Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein.
    The Journal of biological chemistry, 2002, Mar-22, Volume: 277, Issue:12

    Topics: Alanine; Blotting, Northern; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Phenylalanine; Protein Binding; Proteins; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Time Factors; Tissue Distribution; Tumor Cells, Cultured; Umbilical Veins; Up-Regulation

2002
Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II.
    Biochimica et biophysica acta, 2002, Jan-31, Volume: 1594, Issue:1

    Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunoblotting; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Phosphorylation; Pteridines; Pterins

2002
Analysis of xanthophore and pterinosome biogenesis in zebrafish using methylene blue and pteridine autofluorescence.
    Pigment cell research, 2002, Volume: 15, Issue:1

    Topics: Animals; Fluorescence; Light; Methylene Blue; Pteridines; Pterins; Ultraviolet Rays; Zebrafish

2002
Detection of sepiapterin in CSF of patients with sepiapterin reductase deficiency.
    Molecular genetics and metabolism, 2002, Volume: 75, Issue:2

    Topics: Alcohol Oxidoreductases; Chromatography, High Pressure Liquid; Fluorescence; Humans; Pteridines; Pterins

2002
Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:6

    Topics: Acetylcholine; Animals; Aorta; Binding Sites; Biopterins; Cattle; Endothelium, Vascular; Fluorescent Dyes; Free Radicals; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pteridines; Pterins; Reactive Oxygen Species; Rhodamines; Superoxides; Tetrahydrofolates; Vasodilation

2002
Production of sepiapterin in Escherichia coli by coexpression of cyanobacterial GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase.
    Applied and environmental microbiology, 2002, Volume: 68, Issue:6

    Topics: Aldehyde Reductase; Chromatography, High Pressure Liquid; Cyanobacteria; Escherichia coli; GTP Cyclohydrolase; Humans; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Recombinant Proteins

2002
Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biopterins; Cell Movement; Graft Rejection; Kidney; Kidney Transplantation; Kinetics; Macrophages; Models, Biological; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pteridines; Pterins; Rats; Rats, Inbred Lew; Superoxides

2002
Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin.
    Brain research, 2002, May-10, Volume: 935, Issue:1-2

    Topics: Animals; Animals, Newborn; Biopterins; Buthionine Sulfoximine; Coculture Techniques; Dopamine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutathione; Homovanillic Acid; Hypoxanthines; Neostriatum; Organ Culture Techniques; Oxidative Stress; Parkinson Disease; Pteridines; Pterins; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase

2002
Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin.
    Cytokine, 2002, Apr-21, Volume: 18, Issue:2

    Topics: Animals; Biopterins; Cell Fusion; Glucose; Hypoxanthines; Insulin; Insulin Secretion; Insulinoma; Interleukin-1; Islets of Langerhans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Pancreatic Neoplasms; Pteridines; Pterins; Rats; Tumor Cells, Cultured

2002
Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin.
    FEBS letters, 2002, Jul-17, Volume: 523, Issue:1-3

    Topics: Amino Acid Sequence; Animals; Catalysis; Drosophila; Enzyme Stability; Escherichia coli; Hot Temperature; Humans; Kinetics; Molecular Sequence Data; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Recombinant Proteins; Substrate Specificity

2002
Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Oct-01, Volume: 22, Issue:10

    Topics: Acetylcholine; Acetylcysteine; Animals; Antioxidants; Aorta, Thoracic; Arteriosclerosis; Biopterins; Calcimycin; Cholesterol; Diet; Endothelium, Vascular; Free Radical Scavengers; Hyperlipidemias; Ionophores; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Pteridines; Pterins; Rabbits; Sulfhydryl Compounds; Vasodilator Agents

2002
Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Nov-01, Volume: 22, Issue:21

    Topics: Acetylcholine; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biopterins; Blotting, Western; Catecholamines; Cells, Cultured; Ciliary Neurotrophic Factor; Dopamine; Foot; Mice; Neurons; Neurotransmitter Agents; Norepinephrine; Phenotype; Pteridines; Pterins; Skin; Sweat Glands; Sympathetic Fibers, Postganglionic; Tissue Extracts; Tyrosine 3-Monooxygenase

2002
Age estimation of Mexican fruit fly (Diptera: Tephritidae) based on accumulation of pterins.
    Journal of economic entomology, 2002, Volume: 95, Issue:6

    Topics: Aging; Chromatography, High Pressure Liquid; Pteridines; Pterins; Spectrometry, Fluorescence; Temperature; Tephritidae

2002
Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures.
    Journal of neurochemistry, 2003, Volume: 85, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Biopterins; Cell Count; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Dopamine; Dose-Response Relationship, Drug; Electron Transport Complex I; Hypoxanthines; In Vitro Techniques; L-Lactate Dehydrogenase; NADH, NADPH Oxidoreductases; Neurons; Neuroprotective Agents; Nomifensine; Propidium; Pteridines; Pterins; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase

2003
Nitric oxide production by decidual endothelial cells is not reduced in preeclampsia.
    Hypertension in pregnancy, 2003, Volume: 22, Issue:1

    Topics: Adult; Calcimycin; Case-Control Studies; Cells, Cultured; Cyclic GMP; Cytokines; Decidua; Endothelium, Vascular; Epoprostenol; Female; Humans; Nitric Oxide; omega-N-Methylarginine; Pre-Eclampsia; Pregnancy; Pteridines; Pterins; Thromboxane A2; Umbilical Veins

2003
PTERIDINES AS PIGMENTS IN AMPHIBIANS.
    Science (New York, N.Y.), 1964, Jan-31, Volume: 143, Issue:3605

    Topics: Amphibians; Animals; Carotenoids; Chromatophores; Pigmentation; Pteridines; Pterins; Skin

1964
Non-conventional hydrogen bonds: pterins-metal anions.
    Physical chemistry chemical physics : PCCP, 2011, Jul-28, Volume: 13, Issue:28

    Topics: Algorithms; Anions; Copper; Dimerization; Gold; Hydrogen Bonding; Metals; Models, Molecular; Molecular Conformation; Pteridines; Pterins; Silver; Xanthopterin

2011