pteridines has been researched along with sapropterin in 211 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 123 (58.29) | 18.7374 |
| 1990's | 48 (22.75) | 18.2507 |
| 2000's | 35 (16.59) | 29.6817 |
| 2010's | 5 (2.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eldridge, R; Levine, R; Lovenberg, W; Paulson, G; Williams, A | 1 |
| Ayling, JE; Bailey, SW | 1 |
| Abelson, HT; Fosburg, M; Gorka, C; Spector, R | 1 |
| Abelson, HT; Fosburg, M; Levy, P; Spector, R | 1 |
| Bartholomé, K; Bieri, JH; Curtius, HC; Däumling, S; Niederwieser, A; Schaub, J; Schircks, B; Viscontini, M | 1 |
| Bybee, JA; Gál, EM; Sherman, AD | 1 |
| Stone, KJ | 1 |
| Gross, SS; Levi, R | 1 |
| Bult, H; Herman, AG; Jorens, PG; van Overveld, FJ; Vermeire, PA | 1 |
| Blaskovics, M; Blau, N; Curtius, HC; Giudici, T; Kierat, L | 1 |
| Bel, Y; Ferré, J; Jacobson, KB | 1 |
| Bigham, EC; Duch, DS; Edelstein, MP; Smith, GK | 1 |
| Gross, SS; Jaffe, EA; Kilbourn, RG; Levi, R | 1 |
| Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G | 2 |
| Dhondt, JL | 3 |
| Kapatos, G; Kaufman, S; Levine, RA; Milstien, S | 1 |
| Bacher, A; Kerler, F; Schmid, C; Ziegler, I | 1 |
| Donlon, J; Walsh, GA | 1 |
| Curtius, HC; Dahinden, R; Ghisla, S; Kuster, T; Leimbacher, W; Raschdorf, F; Richter, WJ; Steinerstauch, P | 1 |
| Perez-Polo, JR; Shen, RS; Zhang, YX | 1 |
| Bacher, A; Katzenmaier, G; Kerler, F; Le Van, Q; Schmid, C; Schwarzkopf, B; Ziegler, I | 1 |
| Goldberg, A; McIntosh, MJ; Meredith, PA; Moore, MR | 1 |
| Fleischhacker, WW; Meise, U; Schubert, H | 1 |
| Duch, DS; Nichol, CA; Smith, GK | 1 |
| Watts, RW | 1 |
| Abou-Donia, MM; Iuvone, PM; Nichol, CA; Reinhard, JF; Viveros, OH | 1 |
| Katoh, S; Sueoka, T | 2 |
| Abou-Donia, MM; Nichol, CA; Viveros, OH; Wilson, SP; Zimmerman, TP | 1 |
| Aloi, J; Insel, T; Linnoila, M; Lovenberg, W; Miller, L; Murphy, DL; Scheinin, M | 1 |
| Curtius, HC; Heintel, D; Leimbacher, W; Redweik, U; Zagalak, B | 1 |
| Chandrasurin, P; Cichetti, JA; Nichol, CA; Smith, GK | 1 |
| Curtius, HC; Leimbacher, W; Leupold, D; Niederwieser, A; Ponzone, A; Rey, F | 1 |
| Abou-Donia, MA; Duch, DS; Edelstein, MP; Nichol, CA; Viveros, OH; Woolf, JH | 1 |
| Cotton, RG | 1 |
| Bowers, SW; Duch, DS | 1 |
| Bacher, A; Katzenmeier, G; Le Van, Q; Schmid, C; Schwarzkopf, B | 1 |
| Smith, GK | 1 |
| Alam, A; Shen, RS; Zhang, YX | 1 |
| Bosshard, R; Leimbacher, W; Neuheiser, F; Redweik, U; Zagalak, B | 1 |
| Blair, JA; Heales, SJ; Meinschad, C; Ziegler, I | 1 |
| Ellwart, J; Schwulera, U; Ziegler, I | 1 |
| Howells, DW; Hyland, K; Smith, I | 1 |
| Burns, RS; Eldridge, R; Levine, RA; LeWitt, PA; Lovenberg, W; Miller, LP; Newman, RP; Papavasiliou, A; Rayes, A | 1 |
| Abarca, J; Daniels, AJ; Lista, A; Ramos, C | 1 |
| Gustmann, H; Koke, HG; Manzke, H; Nyhan, WL | 1 |
| Barford, PA; Blair, JA; Hamon, CG | 1 |
| Boudha, A; Dhondt, JL; Farriaux, JP; Largillière, C; Leeming, RJ; Ringel, J; Roger, MM | 1 |
| Lee, EH; Mandell, AJ | 1 |
| Blonder, J; Cohen, BE; Normand, M; Peled, I; Quint, J; Szeinberg, A | 1 |
| Müller, WJ; Schwuléra, U; Sonneborn, HH; Ziegler, I | 1 |
| Cotlier, E; Rao, GN | 1 |
| Akino, M; Katoh, S; Masada, M; Sueoka, T | 1 |
| Curtius, HC; Ghisla, S; Heintel, D; Kuster, T; Leimbacher, W; Niederwieser, A | 2 |
| Kaufman, S | 1 |
| Curtius, HC; Niederwieser, A; Ponzone, A | 1 |
| Hyland, K; Kendall, B; Smith, I | 1 |
| Güttler, F; Lou, HC; Lykkelund, C; Niederwieser, A; Rasmussen, V | 1 |
| Howells, D; Hyland, K; Leonard, J; Smith, I | 1 |
| Nichol, CA; Smith, GK | 3 |
| Storm, CB; Williams, TC | 1 |
| Hayaishi, O; Miwa, S; Watanabe, Y | 1 |
| Kaufman, S; Milstien, S | 2 |
| Benkovic, SJ; Bollag, GE; Dix, TA; Domanico, PL | 1 |
| Blair, J; Hagberg, B; Leeming, R; Sahota, A | 1 |
| Abou-Donia, MM; Viveros, OH | 1 |
| Kato, T; Matsuura, S; Nagatsu, T; Oka, K; Sugimoto, T | 1 |
| Levine, RA; Lovenberg, W; Miller, LP | 1 |
| Leeming, RJ | 1 |
| Mandell, AJ; Russo, PV | 2 |
| Blair, JA; Hilburn, ME; Leeming, RJ; McIntosh, MJ; Moore, MR | 1 |
| Bellahsene, Z; Dhondt, JL; Noël, C; Vanhille, P | 1 |
| Angst, J; Curtius, HC; Levine, RA; Lovenberg, W; Niederwieser, A; Woggon, B | 1 |
| Abou-Donia, MM; Duch, DS; Nichol, CA; Viveros, OH | 1 |
| Ballenger, JC; Gold, PW; Kellner, CH; Post, RM; Rakita, RM; Rubinow, DA | 1 |
| Kapatos, G; Kaufman, S; Rizzo, WB; Schulman, JD; Tamarkin, L; Van Loon, GR | 1 |
| Hirata, Y; Iizuka, R; Kondo, T; Nagatsu, I; Nagatsu, T; Narabayashi, H; Oka, K; Rahman, MK; Trocewicz, J; Yamaguchi, T | 1 |
| Levine, RA; Lovenberg, W | 1 |
| Barford, PA; Blair, JA; Coppen, A; Hamon, CG; Leeming, RJ; Morar, C; Pheasant, AE; Reynolds, GP; Whitburn, SB | 1 |
| Culvenor, AJ; Lovenberg, W; Zabrenetzky, V | 1 |
| Berlow, S; Hoganson, G; Kaufman, S; Matalon, R; Milstien, S; Naylor, E; Schuett, V; Seifert, W | 1 |
| Angst, J; Curtius, HC; Niederwieser, A; Woggon, B | 1 |
| Aziz, AA; Blair, JA; Leeming, RJ; Sylvester, PE | 1 |
| Curtius, HC; Niederwieser, A | 1 |
| Harpey, JP | 1 |
| Curtius, HC; Leeming, RJ; Niederwieser, A; Rey, F; Rey, J; Saudubray, JM | 1 |
| Burns, RS; Calne, DB; Insel, T; Levine, RA; LeWitt, PA; Lovenberg, W; Miller, LP; Newman, RP | 1 |
| Brown, GM; Primus, JP; Switchenko, AC | 1 |
| Lipson, A; O'Halloran, M; Potter, M; Wilken, B; Yu, J | 1 |
| Güttler, F; Lou, H; Lykkelund, C; Niederwieser, A | 1 |
| Døskeland, AP; Døskeland, SO; Flatmark, T; Ogreid, D | 1 |
| Chao, JY; Duch, DS; Edelstein, MP; Lee, CL; Nichol, CA | 1 |
| Davidson, JR; Duch, DS; Garbutt, JC; Nichol, CA; Woolf, JH | 1 |
| Armarego, WL; Randles, D; Taguchi, H | 1 |
| Blair, JA; Leeming, RJ; Melikian, V | 1 |
| Beck, B | 1 |
| Combs, AB; Folkers, K; Kappel, M; Lewandowski, E; Vadhanavikit, S | 1 |
| Bräutigam, M; Dreesen, R; Herken, H | 2 |
| Curtius, HC; Levine, R; Müldner, H; Niederwieser, A | 1 |
| Barford, PA; Blair, JA; Leeming, RJ; Smith, I | 1 |
| Kaufman, S; Phillips, RS | 1 |
| Matalon, R | 1 |
| Webber, S; Whiteley, JM | 1 |
| Atarés, M; Blau, N; Cardesa-Garcia, J; Joller, P; Niederwieser, A; Wang, M | 1 |
| Barford, PA; Blair, JA; Eggar, C; Hamon, C; Morar, C; Whitburn, SB | 1 |
| Curtius, HC; Endres, W; Niederwieser, A; Ohrt, B; Schaub, J; Wang, M | 1 |
| Hase, Y; Iwai, K; Kobashi, M; Oura, T; Shintaku, H; Turuhara, T | 1 |
| Kapatos, G; Kaufman, S; Klein, DC; Weller, JL | 1 |
| Eldridge, R; LeWitt, PA; Lovenberg, W; Miller, LP; Newman, RP | 1 |
| Duch, DS; Edelstein, MP; Lee, CL; Nichol, CA | 1 |
| Blair, JA; Leeming, RJ; Morar, C; Whitburn, SB; Wilcock, GK | 1 |
| Blair, JA; Brown, SM; Leeming, RJ | 1 |
| Delcroix, M; Dhondt, JL; Farriaux, JP | 1 |
| Ballenger, J; Bunney, WE; Garbutt, JC; Levine, RA; Lovenberg, WM; Murphy, DL; Sternberg, DE; van Kammen, DP | 1 |
| Hirayama, K; Katoh, S; Masuda, I; Nakanishi, N; Sueoka, T; Yamada, S | 1 |
| Dhondt, JL; Farriaux, JP | 2 |
| Narisawa, K; Tada, K | 1 |
| Curtius, HC; Leupold, D; Niederwieser, A; Wang, M | 1 |
| Kapatos, G; Kaufman, S; McInnes, RR; Rizzo, WB; Schulman, JD | 1 |
| Bräutigam, M; Dreesen, R | 1 |
| Barr, DG; Westwood, A | 1 |
| Ballenger, J; Calne, D; Levine, R; Lovenberg, W; Williams, A | 1 |
| Kapatos, G; Kaufman, S | 1 |
| Kato, T; Matsuura, S; Nagatsu, T; Sugimoto, T; Yamaguchi, T | 1 |
| Knapp, S; Mandell, AJ | 1 |
| Cotton, RG; Danks, DM | 1 |
| Hasegawa, H; Ichiyama, A; Imaizumi, S; Matsuura, S; Sugimoto, T | 1 |
| Gross, SS; Hattori, Y; Levi, R; Madera, A; Park, KH; Vane, J | 1 |
| Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G | 1 |
| Klatt, P; Leopold, E; Mayer, B; Schmid, M; Schmidt, K; Werner, ER | 1 |
| Koshimura, K; Miwa, S; Watanabe, Y | 1 |
| Mühl, H; Pfeilschifter, J | 1 |
| Bachus, KE; Dittman, WA; Mason, SN; McDonald, B; Misukonis, MA; Sauls, DL; Shami, PJ; Smith, GK; Weinberg, JB; Wood, ER | 1 |
| Bacher, A; Huber, R; Meining, W; Nar, H; Schmid, C; Weinkauf, S | 1 |
| Fuchs, D; Hausen, A; Reibnegger, G; Schmidt, K; Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G | 1 |
| Kaufman, S; Ribeiro, P | 1 |
| Koshimura, K; Miwa, S; Ohue, T; Watanabe, Y | 1 |
| Fuchs, D; Lang, F; Wachter, H; Weiss, G; Wöll, E | 1 |
| Billiar, TR; Loftus, M; Robbins, PD; Stuehr, DJ; Tzeng, E | 1 |
| Mayer, B; Wachter, H; Werner, ER; Werner-Felmayer, G | 1 |
| Fan, S; Kaufman, S; Zhuo, S | 1 |
| Cañada, FJ; Lamas, S; Pérez-Sala, D; Saura, M | 1 |
| Katusic, ZS; Milstien, S; Tsutsui, M | 1 |
| Blau, N; de Klerk, JB; Duran, M; Heizmann, CW; Kierat, L; Smeitink, JA; Thöny, B | 1 |
| Chilian, WM; DeFily, DV; Mitchell, M; Tiefenbacher, CP | 1 |
| Gorren, AC; Hemmens, B; List, BM; Mayer, B; Pitters, E; Schmidt, K; Schrammel, A; Werner, ER | 1 |
| Blau, N; Kierat, L; Schaffner, A; Schoedon, G; Walter, R | 1 |
| Garver, RI; Haddad, IY; Hong, J; Matalon, S; Sorscher, EJ; Tzeng, E | 1 |
| Clark, P; Gorren, AC; Mayer, B; Pfeiffer, S; Schmidt, K; Stuehr, DJ; Werner, ER; Wu, C | 1 |
| Beazley, W; Bünz, A; Körner, C; Schallreuter, KU; Schulz-Douglas, V | 1 |
| Ishii, M; Kuroiwa, Y; Momose, K; Shimizu, S; Yamamoto, T | 1 |
| Díaz-Cazorla, M; Jiménez, W; Lamas, S; Pérez-Sala, D; Ros, J | 1 |
| Fitzpatrick, LA; Katusic, ZS; Kullo, IJ; Milstien, S; O'Brien, T; Pompili, VJ; Schwartz, RS; Tsutsui, M | 1 |
| Linscheid, P; Schaffner, A; Schoedon, G | 1 |
| Arai, M; Kondo, A; Mogi, M; Nagatsu, T; Togari, A | 1 |
| Ishii, M; Momose, K; Shimizu, S; Yamamoto, T | 2 |
| Ishii, M; Kawakami, Y; Momose, K; Shimizu, S; Yamamoto, T | 1 |
| Ichinose, H; Nagatsu, T | 1 |
| Bömmel, HM; Frey, A; Fröhlich, LG; Kotsonis, P; Pfleiderer, W; Reif, A; Schmidt, HH; Wink, DA | 1 |
| Katusic, Z; Milstien, S | 1 |
| Al-Masoudi, N; Fröhlich, LG; Hofmann, H; Kotsonis, P; Matter, H; Pfleiderer, W; Schmidt, HH; Strobel, H; Taghavi-Moghadam, S; Traub, H | 1 |
| Ishii, M; Kiuchi, Y; Nawata, S; Shimizu, S; Yamamoto, T | 1 |
| Huang, A; Keaney, JF; Venema, RC; Vita, JA | 1 |
| Kang, UJ; Kowlessur, D; Lei, XG; Milstien, S; Nakamura, K; Wiatr, T; Wright, DA | 1 |
| Hatakeyama, K; Kelly, KA; Marinos, RS; Martinez-Zaguilan, R; Meininger, CJ; Rojas, JD; Wu, G | 1 |
| Eda, S; Masada, M; Yoshida, YI | 1 |
| Heller, R; Mayer, B; Schellenberg, B; Unbehaun, A; Werner, ER; Werner-Felmayer, G | 1 |
| Amann, K; Bleeke, T; Kübler, W; Tiefenbacher, CP; Vahl, C; Vogt, A | 1 |
| Dittrich, P; Gibraeil, HD; Mayer, B; Saleh, S | 1 |
| Assreuy, J; Guimarães, C; Linden, R | 1 |
| Bai, Y; Sagai, M; Suzuki, AK | 1 |
| Freeman, BA; Fukai, T; Harrison, DG; Kurz, S; Laursen, JB; McCann, L; Somers, M; Tarpey, M; Warnholtz, A | 1 |
| Gorren, AC; Kungl, AJ; Mayer, B; Schmidt, K; Werner, ER | 1 |
| Tiefenbacher, CP | 1 |
| Dorrance, AM; Johns, DG; Tramontini, NL; Webb, RC | 1 |
| Beazley, WD; Rokos, H; Schallreuter, KU | 1 |
| Gorren, AC; Mayer, B | 1 |
| Oettl, K; Reibnegger, G | 1 |
| Anderson, TJ; Hyndman, ME; Parsons, HG; Rosenfeld, RJ; Verma, S | 1 |
| Gröne, HJ; Huisman, A; Joles, JA; Martasek, P; Rabelink, TJ; van Faassen, EE; van Zonneveld, AJ; Vanin, AF; Vos, I | 1 |
| Gramsbergen, JB; Kornblit, B; Møller Dall, A; Sandberg, M; Zimmer, J | 1 |
| Cunningham, JM; Stickings, P | 1 |
| Beverley, SM; Cunningham, ML; Lye, LF | 1 |
| Tarpey, MM | 1 |
| Duquaine, D; Kalyanaraman, B; Rajagopalan, S; Vásquez-Vivar, J; Whitsett, J | 1 |
| Habecker, BA; Klein, MG; Li, W; Sundgren, NC; Woodward, WR | 1 |
| Félétou, M; Levens, N; Vanhoutte, PM; Yang, D; Zhang, JN | 1 |
| Gramsbergen, JB; Hesslinger, C; Jansen, P; Madsen, JT; Meyer, M; Zimmer, J | 1 |
| Kashiwagi, A; Masada, M; Okamura, T; Shinozaki, K | 1 |
| Kotsonis, P; Matter, H | 1 |
| Chavan, B; Hafeez, I; Schallreuter, KU; Wood, JM | 1 |
| Wojtasek, H | 1 |
| Fedorov, R; Frey, A; Fröhlich, LG; Ghosh, DK; Hartmann, E; Kotsonis, P; Kumar, HS; Matter, H; Pfleiderer, W; Reif, A; Scheurer, P; Schlichting, I; Schmidt, HH | 1 |
| Kato, T; Mase, K; Nakagoshi, M; Sawada, H; Yamamoto, T | 1 |
| Beverley, SM; Garraway, LA; Nare, B; Vickers, TJ | 1 |
| Cañada-Cañada, F; Espinosa-Mansilla, A; Mancha de Llanos, A; Muñoz de la Peña, A | 1 |
| McHugh, PC | 1 |
| Ambrosio, G; Biondi, R; Capodicasa, E; De Pascali, F; Druhan, LJ; Hemann, C; Tritto, I; Zweier, JL | 1 |
| Suckling, CJ | 1 |
| Jayaraman, A; Nawaz, KA; Palaniswamy, M; Priyadarsini, U; Sabarathinam, S; Thandeeswaran, M | 1 |
19 review(s) available for pteridines and sapropterin
| Article | Year |
|---|---|
Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Body Fluids; Coenzymes; GTP Cyclohydrolase; Humans; Immune System Diseases; Mental Disorders; Metalloproteins; Molybdenum; Molybdenum Cofactors; Neoplasms; Nervous System Diseases; Phenylalanine; Phenylketonurias; Pteridines; Pterins; Tetrahydrofolate Dehydrogenase; Tissue Distribution; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 1985 |
Defects of tetrahydrobiopterin synthesis and their possible relationship to a disorder of purine metabolism (the Lesch-Nyhan syndrome).
Topics: Biopterins; Brain; Dopamine; GTP Cyclohydrolase; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Nervous System Diseases; Neurotransmitter Agents; Pteridines; Pterins; Purines | 1985 |
Pteridines and mono-amines: relevance to neurological damage.
Topics: Amines; Biopterins; Folic Acid; Humans; Nervous System; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines | 1986 |
Biosynthesis of tetrahydrobiopterin in man.
Topics: Alcohol Oxidoreductases; Biopterins; Deuterium; Humans; In Vitro Techniques; Liver; Neopterin; Pteridines; Tetrahydrofolate Dehydrogenase | 1985 |
The role of tetrahydrobiopterin in neurological disease: a review.
Topics: Aluminum; Biopterins; Brain; Dementia; Humans; Lead Poisoning; Nervous System Diseases; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Pteridines | 1981 |
Tetrahydrobiopterin deficiencies: preliminary analysis from an international survey.
Topics: Adjuvants, Pharmaceutic; Alcohol Oxidoreductases; Amino Acid Metabolism, Inborn Errors; Biopterins; Female; Folic Acid; GTP Cyclohydrolase; Humans; Infant; Infant, Newborn; Male; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Pteridines | 1984 |
[Tetrahydroblopterin. Metabolism and metabolic role of unconjugated pteridines (author's transl)].
Topics: Animals; Biological Transport; Biopterins; Cattle; Humans; Mice; Mixed Function Oxygenases; Neoplasms; Neurotic Disorders; Oxidation-Reduction; Phenylalanine; Phenylketonurias; Pteridines; Rats | 1980 |
[Biogenic amines and hyperphenylalaninemia (author's transl)].
Topics: Biogenic Amines; Biopterins; Dihydropteridine Reductase; Humans; Infant; Mass Screening; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines | 1981 |
Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Biopterins; Enzyme Induction; Gene Expression; GTP Cyclohydrolase; Kinetics; Lipopolysaccharides; Models, Biological; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Rats; RNA, Messenger | 1993 |
Modulation of nitric oxide synthase activity in intact cells by intracellular tetrahydrobiopterin levels.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Cells, Cultured; Cytokines; Endothelium, Vascular; Enzyme Induction; Fibroblasts; Humans; Mice; Models, Biological; Nitric Oxide Synthase; Pteridines; Pterins; Umbilical Veins | 1993 |
Biosynthesis of nitric oxide: dependence on pteridine metabolism.
Topics: Animals; Biopterins; Coenzymes; Guanylate Cyclase; Humans; Iron; Mixed Function Oxygenases; Nitric Oxide; Nitric Oxide Synthase; Pteridines | 1996 |
Regulation of pteridine-requiring enzymes by the cofactor tetrahydrobiopterin.
Topics: Amino Acid Sequence; Animals; Biopterins; Coenzymes; Enzyme Activation; Enzymes; Humans; Metabolism, Inborn Errors; Molecular Sequence Data; Pteridines | 1999 |
Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines.
Topics: Animals; Antioxidants; Biopterins; Humans; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Pteridines | 2002 |
Pteridine derivatives as modulators of oxidative stress.
Topics: Animals; Biopterins; Free Radical Scavengers; Humans; Oxidation-Reduction; Oxidative Stress; Pteridines; Pterins | 2002 |
Sepiapterin treatment in atherosclerosis.
Topics: Animals; Arteriosclerosis; Biopterins; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pteridines; Pterins | 2002 |
Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.
Topics: Administration, Oral; Animals; Antioxidants; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Humans; Insulin; Insulin Resistance; Muscle Relaxation; Nitric Oxide Synthase; Oxidative Stress; Pteridines | 2003 |
Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents.
Topics: Animals; Arginine; Binding Sites; Biopterins; Brain Ischemia; Enzyme Inhibitors; Humans; Inflammation; Isoenzymes; Neurodegenerative Diseases; Nitric Oxide Synthase; Protein Conformation; Pteridines; Quantitative Structure-Activity Relationship; Sepsis; Structure-Activity Relationship | 2004 |
The diversity-oriented synthesis of pteridines - achievements and potential for development.
Topics: Biopterins; Carbon; Combinatorial Chemistry Techniques; Drug Design; Halogens; Humans; Molecular Structure; Pteridines; Tetrahydrofolates | 2013 |
Characterization of unexplored amidohydrolase enzyme-pterin deaminase.
Topics: Amidohydrolases; Aminohydrolases; Animals; Biopterins; Eukaryotic Cells; Prokaryotic Cells; Pteridines | 2016 |
4 trial(s) available for pteridines and sapropterin
| Article | Year |
|---|---|
Re-evaluation of antidepressant effect of tetrahydrobiopterin.
Topics: Aged; Antidepressive Agents; Biopterins; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Pteridines | 1985 |
Unsuccessful treatment of depression with tetrahydrobiopterin.
Topics: Biopterins; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electroconvulsive Therapy; Female; Humans; Pteridines | 1984 |
Atypical phenylketonuria due to biopterin deficiency. Early treatment with tetrahydrobiopterin and neurotransmitter precursors, trials of monotherapy.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Clinical Trials as Topic; Humans; Infant; Levodopa; Male; Phenylketonurias; Pteridines | 1982 |
Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid.
Topics: Biopterins; Catalase; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Epidermis; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxidative Stress; Oxygen; Photochemistry; Pteridines; Pterins; Ultraviolet Rays; Vitiligo | 2002 |
188 other study(ies) available for pteridines and sapropterin
| Article | Year |
|---|---|
Low CSF hydroxylase cofactor (tetrahydrobiopterin) levels in inherited dystonia.
Topics: Biopterins; Child; Dystonia; Female; Humans; Pteridines | 1979 |
Separation and properties of the 6-diastereoisomers of l-erythro-tetrahydrobiopterin and their reactivities with phenylalanine hydroxylase.
Topics: Biopterins; Chromatography, High Pressure Liquid; Circular Dichroism; Molecular Conformation; Phenylalanine Hydroxylase; Pteridines; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship | 1978 |
Kinetics of tetrahydrobiopterin synthesis by rabbit brain dihydrofolate reductase.
Topics: Animals; Biopterins; Brain; Kinetics; Phenylalanine Hydroxylase; Pteridines; Rabbits; Tetrahydrofolate Dehydrogenase | 1978 |
Tetrahydrobiopterin synthesis by rabbit brain dihydrofolate reductase.
Topics: Animals; Biopterins; Brain; Pteridines; Rabbits; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1978 |
Tetrahydrobiopterin therapy of atypical phenylketonuria due to defective dihydrobiopterin biosynthesis.
Topics: Biopterins; Female; Humans; Infant; Phenylalanine; Phenylketonurias; Pteridines | 1978 |
Biopterin. V. De novo synthesis of dihydrobiopterin: evidence for its quinonoid structure and lack of dependence of its reduction to tetrahydrobiopterin on dihydrofolate reductase.
Topics: Animals; Biopterins; Brain; Chromatography, Gas; Pteridines; Quinones; Rats; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Tissue Distribution | 1979 |
The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats.
Topics: Animals; Biopterins; Female; Folic Acid Antagonists; Kinetics; Liver; Pteridines; Rats; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1976 |
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Biopterins; Cells, Cultured; Cytosol; Hypoxanthines; Interferon-gamma; Kinetics; Lipopolysaccharides; Male; Methotrexate; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen Consumption; Pteridines; Pterins; Rats; Rats, Inbred F344; Recombinant Proteins | 1992 |
Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Citrulline; Hypoxanthines; Interferon-gamma; Macrophages, Alveolar; Male; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Rats; Rats, Wistar; Recombinant Proteins | 1992 |
Hyperphenylalaninaemia presumably due to carbinolamine dehydratase deficiency: loading tests with pterin derivatives.
Topics: Biopterins; Female; Humans; Hydro-Lyases; Infant, Newborn; Kinetics; Phenylalanine; Pteridines; Pterins | 1992 |
A comparative study of Drosophila phenylalanine hydroxylase with a natural and a synthetic tetrahydropterin as cofactor.
Topics: Animals; Biopterins; Coenzymes; Drosophila melanogaster; Kinetics; Phenylalanine Hydroxylase; Pteridines; Pterins; Substrate Specificity | 1992 |
New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines.
Topics: Alcohol Oxidoreductases; Biopterins; Cell Division; Cell Line; Humans; Kinetics; Models, Molecular; Molecular Conformation; Molecular Structure; Pteridines; Pterins; Pyrimidines; Serotonin; Structure-Activity Relationship | 1992 |
Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Calmodulin; Cells, Cultured; Cycloheximide; Cytokines; Endothelium, Vascular; Interferon-gamma; Isoenzymes; Kinetics; Macrophage Activation; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1991 |
Relationships between pteridine synthesis and tryptophan degradation.
Topics: Biopterins; Cells, Cultured; Enzyme Induction; Humans; Hydrolases; Interferon-gamma; Macrophages; NAD; Neopterin; Pteridines; Tryptophan; Tryptophan Oxygenase | 1991 |
Strategy for the screening of tetrahydrobiopterin deficiency among hyperphenylalaninaemic patients: 15-years experience.
Topics: Belgium; Biopterins; Czechoslovakia; Diagnosis, Differential; Dihydropteridine Reductase; France; Humans; Infant, Newborn; Liver; Neonatal Screening; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Portugal; Prospective Studies; Pteridines; Retrospective Studies | 1991 |
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.
Topics: Animals; Biopterins; Cells, Cultured; Cytokines; Fibroblasts; Interferon-gamma; Interleukin-1; Kinetics; Methotrexate; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Pteridines; Pterins; Recombinant Proteins; Skin; Sugar Acids; Tumor Necrosis Factor-alpha | 1990 |
Immunological evidence for the requirement of sepiapterin reductase for tetrahydrobiopterin biosynthesis in brain.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Blotting, Western; Brain; Chemical Phenomena; Chemistry; Electrophoresis, Gel, Two-Dimensional; Immunoblotting; Pteridines; Rats | 1990 |
Synthesis of tetrahydrobiopterin in Friend erythroleukemia cells and its modulator effect on cell proliferation.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cell Division; Clone Cells; Dimethyl Sulfoxide; DNA Replication; Enzyme Induction; GTP Cyclohydrolase; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phenylalanine Hydroxylase; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Tumor Cells, Cultured | 1990 |
Dexamethasone and phenylalanine hydroxylase activities in rats.
Topics: Animals; Biopterins; Dexamethasone; Liver; Male; Phenylalanine Hydroxylase; Pteridines; Rats; Rats, Inbred Strains | 1990 |
1H-NMR and mass spectrometric studies of tetrahydropterins. Evidence for the structure of 6-pyruvoyl tetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin.
Topics: Alcohol Oxidoreductases; Biopterins; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Neopterin; Oxidation-Reduction; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Stereoisomerism | 1990 |
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animals; Biopterins; Cell Line; Colforsin; Cycloheximide; Dihydropteridine Reductase; GTP Cyclohydrolase; Isoenzymes; Kinetics; Pheochromocytoma; Pteridines; Pterins; Rats; Reserpine; Theophylline | 1989 |
Biosynthesis of tetrahydrobiopterin: a sensitive assay of 6-pyruvoyltetrahydropterin synthase using [2'-3H]dihydroneopterin 3'-triphosphate as substrate.
Topics: Adsorption; Alcohol Oxidoreductases; Animals; Biopterins; Charcoal; Chemical Phenomena; Chemistry; Edetic Acid; Escherichia coli; Liver; Magnesium; Mice; Neopterin; Phosphorus-Oxygen Lyases; Pteridines; Tritium | 1989 |
Neurotoxic action of lead: effect on tetrahydrobiopterin metabolism in the rat.
Topics: Animals; Biopterins; Body Weight; Bone and Bones; Brain; Dihydropteridine Reductase; Lead; Lead Poisoning; Male; Neurotoxins; Pteridines; Rats; Rats, Inbred Strains; Tissue Distribution | 1985 |
Stimulation of retinal dopamine biosynthesis in vivo by exogenous tetrahydrobiopterin: relationship to tyrosine hydroxylase activation.
Topics: Animals; Biopterins; Dark Adaptation; Dihydroxyphenylalanine; Dopamine; Enzyme Activation; Light; Male; Pteridines; Rats; Rats, Inbred Strains; Retina; Tyrosine 3-Monooxygenase | 1985 |
Development of tetrahydrobiopterin and GTP cyclohydrolase in salivary glands of rats.
Topics: Aging; Aminohydrolases; Animals; Biopterins; GTP Cyclohydrolase; Kinetics; Male; Pteridines; Rats; Rats, Inbred Strains; Salivary Glands; Tyrosine 3-Monooxygenase | 1986 |
Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Medulla; Aminohydrolases; Animals; Biopterins; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cyclic AMP; GTP Cyclohydrolase; Pteridines; Pterins; Serotonin; Tyrosine; Tyrosine 3-Monooxygenase | 1986 |
Tetrahydrobiopterin administration to rhesus macaques. Its appearance in CSF and effect on neurotransmitter synthesis.
Topics: Animals; Biopterins; Blood-Brain Barrier; Dopamine; Injections, Intravenous; Macaca mulatta; Male; Neurotransmitter Agents; Norepinephrine; Pteridines; Serotonin; Time Factors | 1986 |
Purification and properties of the phosphate eliminating enzyme involved in the biosynthesis of BH4 in man.
Topics: Biopterins; Humans; Isoelectric Point; Liver; Magnesium; Molecular Weight; NADP; Neopterin; Pteridines; Pyrophosphatases; Temperature; Time Factors | 1985 |
The C-6 proton of tetrahydrobiopterin is acquired from water, not NADPH, during de novo biosynthesis.
Topics: Animals; Biopterins; Cattle; Deuterium; Gas Chromatography-Mass Spectrometry; Guanosine Triphosphate; Models, Chemical; NADP; Protons; Pteridines | 1985 |
Atypical phenylketonuria with "dihydrobiopterin synthetase" deficiency: absence of phosphate-eliminating enzyme activity demonstrated in liver.
Topics: Adult; Alcohol Oxidoreductases; Biopterins; Chemical Phenomena; Chemistry; Child; Child, Preschool; Female; Humans; Infant; Liver; Male; Neopterin; Phenylketonurias; Pteridines; Pyrophosphatases | 1985 |
Regulation of tetrahydrobiopterin biosynthesis in cultured adrenal cortical tumor cells by adrenocorticotropin and adenosine 3',5'-cyclic monophosphate.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Animals; Biopterins; Bucladesine; Cell Line; Colforsin; Cosyntropin; Cyclic AMP; GTP Cyclohydrolase; Hydroxyprogesterones; Mice; Mutation; Progesterone; Pteridines | 1986 |
A model for hyperphenylalaninaemia due to tetrahydrobiopterin deficiency.
Topics: Animals; Biopterins; Brain; Catecholamines; Disease Models, Animal; Dose-Response Relationship, Drug; Hypoxanthines; Liver; Mice; Mice, Inbred BALB C; Phenylalanine; Pteridines | 1986 |
In vivo measurement of dihydrofolate reductase and its inhibition by antifolates.
Topics: Animals; Biopterins; Brain; Folic Acid Antagonists; Injections, Intraventricular; Liver; Male; Methotrexate; Mice; Pteridines; Pterins; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase | 1988 |
Biosynthesis of biopterin. Studies on the mechanism of 6-pyruvoyltetrahydropteridine synthase.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Neopterin; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Substrate Specificity | 1988 |
On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin.
Topics: Alcohol Oxidoreductases; Animals; Antigen-Antibody Complex; Biopterins; Erythrocytes; Kinetics; Male; Molecular Weight; Pteridines; Pterins; Rats; Substrate Specificity; Tissue Distribution | 1987 |
Inhibition of GTP cyclohydrolase I by pterins.
Topics: Aminohydrolases; Animals; Biopterins; Folic Acid; GTP Cyclohydrolase; Kinetics; Liver; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Rats; Xanthopterin | 1988 |
Synthesis of enzymatically active D-7,8-dihydroneopterin-3'-triphosphate.
Topics: Biopterins; Methods; Neopterin; Pteridines | 1988 |
Inhibition of monocyte luminol-dependent chemiluminescence by tetrahydrobiopterin, and the free radical oxidation of tetrahydrobiopterin, dihydrobiopterin and dihydroneopterin.
Topics: Ascorbic Acid; Biopterins; Dithioerythritol; Free Radicals; Humans; Hydrogen Peroxide; In Vitro Techniques; Luminescent Measurements; Macrophages; Monocytes; Neopterin; Oxidation-Reduction; Pteridines | 1988 |
Pteridines are produced during interleukin 2-induced T-cell proliferation and modulate transmission of this signal.
Topics: Biopterins; Cell Cycle; Cell Division; Cells, Cultured; Humans; Interleukin-2; Pteridines; T-Lymphocytes | 1986 |
Tetrahydrobiopterin in dystonia: identification of abnormal metabolism and therapeutic trials.
Topics: Adult; Aged; Biopterins; Dystonia; Female; Humans; Male; Middle Aged; Neopterin; Pteridines | 1986 |
Rat striatal dopamine and tetrahydrobiopterin content following an intrastriatal injection of manganese chloride.
Topics: Animals; Biopterins; Chlorides; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Manganese; Manganese Compounds; Pteridines; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Hypoxanthine and tetrahydrobiopterin treatment of a patient with features of the Lesch-Nyhan syndrome.
Topics: Adult; Allopurinol; Biopterins; Drug Administration Schedule; Humans; Hypoxanthine; Hypoxanthines; Lesch-Nyhan Syndrome; Male; Pteridines; Serotonin | 1986 |
The effect of tetrahydrofolate on tetrahydrobiopterin metabolism.
Topics: Adult; Aged; Alzheimer Disease; Animals; Biopterins; Child, Preschool; Humans; In Vitro Techniques; Infant; Male; Middle Aged; Pteridines; Rats; Rats, Inbred Strains; Temporal Lobe; Tetrahydrofolates; Vitamin B 12 | 1986 |
[GTP cyclohydrolase activity in rat liver].
Topics: Aminohydrolases; Animals; Biopterins; Carbon Radioisotopes; GTP Cyclohydrolase; Liver; Male; Pteridines; Pterins; Rats; Rats, Inbred Strains | 1985 |
Neonatal hyperphenylalaninemia presumably caused by guanosine triphosphate-cyclohydrolase deficiency.
Topics: Aminohydrolases; Biopterins; GTP Cyclohydrolase; Humans; Infant, Newborn; Leukocyte Count; Liver; Male; Neopterin; Phenylalanine; Pteridines; Pterins; T-Lymphocytes | 1985 |
Relationships between drug-induced changes in tetrahydrobiopterin and biogenic amine concentrations in rat brain.
Topics: Animals; Biogenic Amines; Biopterins; Brain Chemistry; Circadian Rhythm; Cocaine; Corticotropin-Releasing Hormone; Dextroamphetamine; Male; Methylphenidate; Pteridines; Rats; Rats, Inbred Strains; Tryptophan; Valine | 1985 |
Malignant phenylketonuria due to defective synthesis of dihydrobiopterin.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Drug Combinations; Female; Humans; Infant, Newborn; Levodopa; Male; Nervous System Diseases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine | 1985 |
Modulation of interleukin 2 activity by lymphocyte-derived tetrahydrobiopterin.
Topics: Animals; Biopterins; DNA; Humans; Interleukin-2; Lymphocytes; Mice; Pteridines; T-Lymphocytes | 1985 |
The enzymatic activities of GTP cyclohydrolase, sepiapterin reductase, dihydropteridine reductase and dihydrofolate reductase; and tetrahydrobiopterin content in mammalian ocular tissues and in human senile cataracts.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cataract; Cattle; Ciliary Body; Dihydropteridine Reductase; Eye; GTP Cyclohydrolase; Humans; Iris; Lens, Crystalline; Pteridines; Rabbits; Rats; Retina; Tetrahydrofolate Dehydrogenase | 1985 |
Dyspropterin, an intermediate formed from dihydroneopterin triphosphate in the biosynthetic pathway of tetrahydrobiopterin.
Topics: Alcohol Oxidoreductases; Biopterins; Catalysis; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydropteridine Reductase; Hydroxylation; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Spectrophotometry, Ultraviolet | 1985 |
Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved.
Topics: Affinity Labels; Alcohol Oxidoreductases; Animals; Biopterins; Catalysis; Chromatography, High Pressure Liquid; Energy Transfer; Erythrocytes; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen Bonding; Kinetics; Liver; NADP; Oxidation-Reduction; Pteridines; Rats; Solvents; Stereoisomerism; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1985 |
Hyperphenylalaninaemia caused by defects in biopterin metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Biogenic Amines; Biopterins; Brain; Humans; Phenylalanine; Phenylketonurias; Pteridines | 1985 |
Differential diagnosis of tetrahydrobiopterin deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Biopterins; Diagnosis, Differential; GTP Cyclohydrolase; Humans; Phenylalanine; Phenylketonurias; Pteridines | 1985 |
Clinical role of pteridine therapy in tetrahydrobiopterin deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Biogenic Amines; Biopterins; Brain; Folic Acid; Folic Acid Deficiency; Humans; Infant; Phenylalanine; Phenylketonurias; Pteridines | 1985 |
Biopterin, neopterin and tyrosine responses to combined oral phenylalanine and tetrahydrobiopterin loading tests in two normal children and in a girl with partial biopterin deficiency.
Topics: Administration, Oral; Biopterins; Child; Female; Humans; Neopterin; Phenylalanine; Pteridines; Tyrosine | 1985 |
Tetrahydrobiopterin in dihydropteridine reductase deficiency.
Topics: Biopterins; Humans; NADH, NADPH Oxidoreductases; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines | 1986 |
Synthesis, utilization, and structure of the tetrahydropterin intermediates in the bovine adrenal medullary de novo biosynthesis of tetrahydrobiopterin.
Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chromatography, High Pressure Liquid; Kinetics; Pteridines; Serotonin; Spectrophotometry, Ultraviolet | 1986 |
Tetrahydrobiopterin analogues: solution conformations of 6-methyltetrahydropterin, 7-methyltetrahydropterin, and cis- and trans-6,7-dimethyltetrahydropterins as determined by proton nuclear magnetic resonance.
Topics: Biopterins; Hydrogen-Ion Concentration; Isomerism; Magnetic Resonance Spectroscopy; Molecular Conformation; Pteridines; Solutions; Stereoisomerism; Structure-Activity Relationship | 1985 |
6R-L-erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain.
Topics: Animals; Biopterins; Brain; Dopamine; Hydroxylation; Isomerism; Probenecid; Pteridines; Rats; Serotonin; Time Factors; Tryptophan; Tyrosine | 1985 |
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates.
Topics: Adrenal Medulla; Animals; Biopterins; Brain; Cattle; Chemical Phenomena; Chemistry; In Vitro Techniques; Kinetics; Liver; Neopterin; Pteridines; Pterins; Rats | 1985 |
Phenylalanine hydroxylase: absolute configuration and source of oxygen of the 4a-hydroxytetrahydropterin species.
Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; Circular Dichroism; Gas Chromatography-Mass Spectrometry; Liver; Magnetic Resonance Spectroscopy; Optical Rotation; Phenylalanine Hydroxylase; Pteridines; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship | 1985 |
Tetrahydrobiopterin metabolism in the Rett disease.
Topics: Biopterins; Child; Dihydropteridine Reductase; Female; Humans; Intellectual Disability; NADH, NADPH Oxidoreductases; Neurocognitive Disorders; Pteridines; Stereotyped Behavior; Syndrome | 1985 |
Tetrahydrobiopterin increases in adrenal medulla and cortex: a factor in the regulation of tyrosine hydroxylase.
Topics: Adrenal Cortex; Adrenal Glands; Adrenal Medulla; Animals; Biopterins; Catecholamines; Cycloheximide; Denervation; Hypophysectomy; Insulin; Kinetics; Male; Pteridines; Rats; Reserpine; Tyrosine 3-Monooxygenase | 1981 |
Kinetic properties of tyrosine hydroxylase with natural tetrahydrobiopterin as cofactor.
Topics: Adrenal Medulla; Animals; Biopterins; Cattle; In Vitro Techniques; Kinetics; Pteridines; Stereoisomerism; Tyrosine 3-Monooxygenase | 1981 |
Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis.
Topics: Aminohydrolases; Animals; Biopterins; Corpus Striatum; Dopamine; GTP Cyclohydrolase; Hydroxydopamines; Male; Pteridines; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine 3-Monooxygenase | 1981 |
Short-term regulation of hydroxylase cofactor activity in rat brain.
Topics: Animals; Biopterins; Circadian Rhythm; Corpus Striatum; Dextroamphetamine; Kinetics; Locus Coeruleus; Male; Oxidoreductases; Physostigmine; Pteridines; Pterins; Quinones; Rats; Rats, Inbred Strains; Reserpine; Tyrosine 3-Monooxygenase | 1981 |
Lead and tetrahydrobiopterin metabolism: possible effects on IQ.
Topics: Adolescent; Adult; Aged; Biopterins; Child; Child, Preschool; Cognition; Female; Humans; Infant; Intelligence; Lead; Male; Middle Aged; Pteridines | 1982 |
Tetrahydrobiopterin metabolism in chronic uraemia: possible explanation of dialysis encephalopathy.
Topics: Biopterins; Brain Diseases; Chronic Disease; Humans; Pteridines; Renal Dialysis; Uremia | 1982 |
Successful treatment of depression with tetrahydrobiopterin.
Topics: Biogenic Amines; Biopterins; Depressive Disorder; Female; Humans; Middle Aged; Pteridines | 1983 |
Hormonal regulation of guanosine triphosphate cyclohydrolase activity and biopterin levels in the rat adrenal cortex.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Biopterins; Cosyntropin; Cycloheximide; Guanylate Cyclase; Hypophysectomy; Insulin; Kinetics; Male; Pteridines; Rats; Rats, Inbred Strains; Reserpine; Tetrahydrofolate Dehydrogenase | 1983 |
Tetrahydrobiopterin levels in cerebrospinal fluid of affectively ill patients.
Topics: Adult; Aged; Biopterins; Depressive Disorder; Humans; Middle Aged; Pteridines | 1983 |
Tetrahydropterin therapy for hyperphenylalaninemia caused by defective synthesis of tetrahydrobiopterin.
Topics: Biopterins; Blood Glucose; Child; Dose-Response Relationship, Drug; Growth Hormone; Humans; Male; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Prolactin; Pteridines; Pterins | 1983 |
Catecholamine-related enzymes and the biopterin cofactor in Parkinson's disease and related extrapyramidal diseases.
Topics: Adult; Aged; Aromatic-L-Amino-Acid Decarboxylases; Basal Ganglia Diseases; Biopterins; Brain; Dopa Decarboxylase; Dopamine beta-Hydroxylase; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenylethanolamine N-Methyltransferase; Pteridines; Shy-Drager Syndrome; Tyrosine 3-Monooxygenase | 1984 |
CSF tetrahydrobiopterin levels in patients with affective disorders.
Topics: Biopterins; Chromatography, High Pressure Liquid; Humans; Mood Disorders; Pteridines | 1984 |
A kinetic scattering approach to the non-linear instabilities of rat brain tyrosine hydroxylase preparations at several levels of tetrahydrobiopterin cofactor demonstrates evolutionary behavior characteristic of global dynamical systems.
Topics: Animals; Biological Evolution; Biopterins; Corpus Striatum; Kinetics; Male; Models, Chemical; Pteridines; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 1984 |
Tetrahydrobiopterin metabolism in depression.
Topics: Adult; Aged; Biopterins; Brain; Humans; Middle Aged; Mood Disorders; Pteridines | 1984 |
Effect of dexamethasone on biopterin levels and tyrosine hydroxylase activity in PC-12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Biopterins; Catecholamines; Cell Line; Dexamethasone; Pheochromocytoma; Pteridines; Rats; Tyrosine 3-Monooxygenase | 1984 |
Biopterin synthesis defects: problems in diagnosis.
Topics: Biopterins; Diet; Female; Humans; Infant, Newborn; Metabolism, Inborn Errors; Neopterin; Neurotransmitter Agents; Phenylalanine; Pteridines | 1984 |
Tetrahydrobiopterin metabolism in Down's syndrome and in non-Down's syndrome mental retardation.
Topics: Adult; Aged; Biopterins; Down Syndrome; Female; Humans; Intellectual Disability; Male; Middle Aged; Phenylalanine; Pteridines | 1982 |
[Development of the biosynthesis and excretion of pterins in phenylketonuria and its variants].
Topics: Alcohol Oxidoreductases; Biopterins; Child; Chromatography, High Pressure Liquid; Humans; Phenylalanine; Phenylketonurias; Pteridines; Pterins | 1983 |
[Biopterin synthesis defects: complete deficiencies (reductase and synthetase)].
Topics: Alcohol Oxidoreductases; Biopsy, Needle; Biopterins; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Liver; Phenylalanine; Phenylketonurias; Pteridines; Pterins | 1983 |
[Partial deficiency of tetrahydrobiopterin].
Topics: Adolescent; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Female; Humans; Infant, Newborn; Male; Phenylalanine; Phenylketonurias; Pteridines; Pterins | 1983 |
Tetrahydro-sepiapterin is an intermediate in tetrahydrobiopterin biosynthesis.
Topics: Adrenal Medulla; Alcohol Oxidoreductases; Animals; Biopterins; Cattle; Escherichia coli; GTP Cyclohydrolase; Leuconostoc; Melatonin; Pteridines; Pterins; Serotonin; Tetrahydrofolate Dehydrogenase | 1983 |
Tyrosine hydroxylase cofactor (tetrahydrobiopterin) in parkinsonism.
Topics: Adult; Age Factors; Aged; Animals; Antiparkinson Agents; Biopterins; Brain Chemistry; Drug Evaluation, Preclinical; Haplorhini; Humans; Middle Aged; Parkinson Disease; Pteridines; Rats | 1984 |
Intermediates in the enzymic synthesis of tetrahydrobiopterin in Drosophila melanogaster.
Topics: Animals; Biopterins; Biotransformation; Catalysis; Drosophila melanogaster; Edetic Acid; Magnesium; NADP; Neopterin; Pteridines; Pterins | 1984 |
Dihydropteridine reductase deficiency: non-response to oral tetrahydrobiopterin load test.
Topics: Biopterins; Female; Fibroblasts; Humans; Infant; Lymphocytes; NADH, NADPH Oxidoreductases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine | 1984 |
Combined tetrahydrobiopterin-phenylalanine loading test in the detection of partially defective biopterin synthesis.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Biopterins; Child; Child, Preschool; Electroencephalography; Female; Humans; Neopterin; Phenylalanine; Pteridines | 1984 |
The effect of ligands of phenylalanine 4-monooxygenase on the cAMP-dependent phosphorylation of the enzyme.
Topics: Adenosine Diphosphate; Animals; Biopterins; Kinetics; Magnesium; Phenylalanine; Phenylalanine Hydroxylase; Phosphorylation; Protein Kinases; Pteridines; Rats; Time Factors | 1984 |
Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.
Topics: Adrenal Medulla; Animals; Biopterins; Brain; Cattle; Cells, Cultured; Cricetinae; Guanosine Triphosphate; Methotrexate; Mice; Pteridines; Pterins; Rats | 1983 |
Urinary excretion of biopterin and neopterin in psychiatric disorders.
Topics: Adult; Biopterins; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Neopterin; Pteridines; Schizophrenia | 1984 |
Peroxidase catalysed aerobic degradation of 5,6,7,8-tetrahydrobiopterin at physiological pH.
Topics: Aerobiosis; Biopterins; Catalysis; Chemical Phenomena; Chemistry; Dihydropteridine Reductase; Horseradish Peroxidase; Humans; Hydrogen-Ion Concentration; Liver; Oxidation-Reduction; Peroxidases; Pteridines; Spectrophotometry, Ultraviolet; Stereoisomerism | 1983 |
Tetrahydrobiopterin is synthesized by separate pathways from dihydroneopterin triphosphate and from sepiapterin in adrenal medulla preparations.
Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chemical Phenomena; Chemistry; Guanosine Triphosphate; Methotrexate; Neopterin; Pteridines; Pterins | 1983 |
Intestinal absorption of tetrahydrobiopterin and biopterin in man.
Topics: Ascorbic Acid; Biopterins; Ethanol; Humans; Intestinal Absorption; Pteridines | 1983 |
[Hyperphenylalaninemia on account of biopterin deficiency. The phenylalanine hydroxylase complex and presentation of a patient with cofactor deficiency].
Topics: Biopterins; Humans; Infant; Male; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines | 1983 |
Study of tetrahydrobiopterin and 6-methyltetrahydropterin on alcohol dependence in mice.
Topics: Alcoholism; Animals; Biopterins; Ethanol; Female; Humans; Mice; Pteridines; Pterins; Substance Withdrawal Syndrome | 1983 |
Tetrahydrobiopterin and total biopterin content of neuroblastoma (N1E-115, N2A) and pheochromocytoma (PC-12) clones and the dependence of catecholamine synthesis on tetrahydrobiopterin concentration in PC-12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Biopterins; Catecholamines; Cell Line; Chromatography, High Pressure Liquid; Kinetics; Mice; Neuroblastoma; Pheochromocytoma; Pteridines; Rats | 1984 |
Therapeutic efficacy of tetrahydrobiopterin in Parkinson's disease.
Topics: Aged; Antidepressive Agents; Antiparkinson Agents; Biopterins; Brain; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines | 1984 |
Blood spots on Guthrie cards can be used for inherited tetrahydrobiopterin deficiency screening in hyperphenylalaninaemic infants.
Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Dihydropteridine Reductase; Humans; Infant, Newborn; Methods; Phenylalanine; Phenylketonurias; Pteridines; Specimen Handling | 1984 |
Ligand effects on the phosphorylation state of hepatic phenylalanine hydroxylase.
Topics: Animals; Biopterins; Enzyme Activation; Kinetics; Ligands; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Phosphorylation; Protein Kinases; Pteridines; Rats; Rats, Inbred Strains | 1984 |
Current status of biopterin screening.
Topics: Biopterins; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Mass Screening; Neopterin; Phenylalanine; Phenylketonurias; Pteridines | 1984 |
An abbreviated synthesis of tetrahydropteridines.
Topics: Biopterins; Chemical Phenomena; Chemistry; Isomerism; Pteridines; Pterins; Temperature | 1984 |
Two new tetrahydropterin intermediates in the adrenal medullary de novo biosynthesis of tetrahydrobiopterin.
Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chromatography, High Pressure Liquid; Electrochemistry; Kinetics; NADP; Oxidation-Reduction; Pteridines; Pterins | 1984 |
GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia.
Topics: Adolescent; Aminohydrolases; Biopterins; Child; Child, Preschool; Dopamine; Female; GTP Cyclohydrolase; Humans; Infant; Liver; Metabolism, Inborn Errors; Muscle Hypotonia; Neopterin; Phenylalanine; Pteridines; Serotonin | 1984 |
Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type.
Topics: Aged; Alzheimer Disease; Biopterins; Dihydropteridine Reductase; Humans; Kinetics; Neopterin; Pteridines; Temporal Lobe | 1984 |
A case of tetrahydrobiopterin deficiency due to a defective synthesis of dihydrobiopterin.
Topics: Biopterins; Humans; Infant; Male; Phenylalanine; Pteridines | 1982 |
The development of tetrahydrobiopterin and guanosine-5'-triphosphate cyclohydrolase: differential patterns in rat brain and pineal gland.
Topics: Aging; Aminohydrolases; Animals; Biopterins; Brain; Female; GTP Cyclohydrolase; Male; Organ Specificity; Pineal Gland; Pteridines; Rats; Rats, Inbred Strains; Sex Factors | 1983 |
Treatment of dystonia with tetrahydrobiopterin.
Topics: Adult; Aged; Biopterins; Dystonia; Humans; Middle Aged; Pteridines | 1983 |
Biosynthesis of tetrahydrobiopterin in the presence of dihydrofolate reductase inhibitors.
Topics: Animals; Biopterins; Cell Line; Clone Cells; Folic Acid Antagonists; GTP Cyclohydrolase; Guanosine Triphosphate; Male; Methotrexate; Neuroblastoma; Pteridines; Rats; Rats, Inbred Strains | 1983 |
Tetrahydrobiopterin metabolism in senile dementia of Alzheimer type.
Topics: Aged; Alzheimer Disease; Biopterins; Chromatography, High Pressure Liquid; Dementia; Humans; Middle Aged; Pteridines | 1983 |
Regulation of pterin synthesis.
Topics: Biopterins; Dihydropteridine Reductase; Dopamine; Guanosine Triphosphate; Humans; Phenylpyruvic Acids; Pteridines | 1983 |
Unconjugated pteridines in human milk.
Topics: Animals; Biopterins; Drug Stability; Female; Humans; Milk; Pteridines | 1982 |
Cerebrospinal fluid hydroxylase cofactor in schizophrenia.
Topics: Adult; Biopterins; Blood Platelets; Female; Humans; Male; Monoamine Oxidase; Pteridines; Schizophrenia; Schizophrenic Psychology | 1982 |
[Phenylalanine hydroxylating activity in Tawa sarcoma].
Topics: Animals; Biopterins; Hydroxylation; Liver Neoplasms; Neoplasms, Experimental; Phenylalanine Hydroxylase; Pteridines; Rats; Rats, Inbred Strains; Sarcoma | 1981 |
Determination of reduced biopterins by high pressure liquid chromatography and subsequent electrochemical detection.
Topics: Biopterins; Chromatography, High Pressure Liquid; Electrochemistry; Electrodes; Indicators and Reagents; Pteridines; Spectrophotometry, Ultraviolet | 1982 |
Atypical phenylketonuria with defective biopterin metabolism. Monotherapy with tetrahydrobiopterin or sepiapterin, screening and study of biosynthesis in man.
Topics: Biopterins; Child, Preschool; Female; Humans; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins; Serotonin | 1982 |
Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin: evidence that peripherally administered tetrahydropterins enter the brain.
Topics: Biopterins; Brain; Child; Child, Preschool; Female; Humans; Male; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins | 1982 |
Determination of L-erythro-tetrahydrobiopterin in biological tissues by high pressure liquid chromatography and electrochemical detection.
Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; Corpus Striatum; Electrochemistry; Medulla Oblongata; Pteridines; Rats | 1982 |
Phenylketonuria with a progressive neurological disorder not responsive to tetrahydrobiopterin.
Topics: Biopterins; Female; Humans; Infant; Nerve Degeneration; Phenylketonurias; Pteridines | 1982 |
Aging and CSF hydroxylase cofactor.
Topics: Adult; Aged; Aging; Biopterins; Humans; Middle Aged; Parkinson Disease; Pteridines | 1980 |
Peripherally administered reduced pterins do enter the brain.
Topics: Animals; Biopterins; Blood-Brain Barrier; Brain; Male; Pteridines; Pterins; Rats; Stereoisomerism; Structure-Activity Relationship | 1981 |
[Hyperphenylalaninemia in 1981. A diagnostic approach (author's transl)].
Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Clinical Enzyme Tests; Diagnosis, Differential; Dihydropteridine Reductase; Humans; Infant; Infant, Newborn; Liver; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines | 1981 |
Effects of structures of tetrahydropterin cofactors on rat brain tryptophan hydroxylase.
Topics: Animals; Biopterins; Brain; Kinetics; Pteridines; Rats; Structure-Activity Relationship; Tryptophan Hydroxylase | 1980 |
Lithium and chlorimipramine differentially alter bilateral asymmetry in mesostriatal serotonin metabolites and kinetic conformations of midbrain tryptophan hydroxylase with respect to tetrahydrobiopterin cofactor.
Topics: Animals; Biopterins; Clomipramine; Corpus Striatum; Kinetics; Lithium; Male; Mesencephalon; Protein Conformation; Pteridines; Rats; Serotonin; Tryptophan Hydroxylase | 1980 |
Early diagnosis of hyperphenylalaninemia due to tetrahydrobiopterin deficiency (malignant hyperphenylalaninemia).
Topics: Biopterins; Humans; Infant, Newborn; Phenylalanine; Phenylketonurias; Pteridines | 1980 |
Studies on biologically active pteridines. III. The absolute configuration at the C-6 chiral center of tetrahydrobiopterin cofactor and related compounds.
Topics: Biopterins; Circular Dichroism; Molecular Conformation; Pteridines; Stereoisomerism | 1980 |
The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.
Topics: Allosteric Regulation; Amino Acid Oxidoreductases; Animals; Biopterins; Brain; Indazoles; Kinetics; Nitric Oxide Synthase; Pteridines; Substrate Specificity; Swine | 1994 |
Dopamine-releasing action of 6R-L-erythro-tetrahydrobiopterin: analysis of its action site using sepiapterin.
Topics: alpha-Methyltyrosine; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Biopterins; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Isomerism; Kinetics; Male; Methyltyrosines; Microdialysis; Nitric Oxide Synthase; Pteridines; Pterins; Rats; Rats, Wistar; Time Factors; Tyrosine 3-Monooxygenase | 1994 |
Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Cells, Cultured; Dose-Response Relationship, Drug; Glomerular Mesangium; GTP Cyclohydrolase; Guanosine Triphosphate; Hypoxanthines; Interleukin-1; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Rats; Recombinant Proteins | 1994 |
Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Base Sequence; Biopterins; Cell Line; DNA Primers; Enzyme Induction; Gene Expression; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Monocytes; Nitrates; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; RNA, Messenger | 1995 |
Atomic structure of GTP cyclohydrolase I.
Topics: Alcohol Oxidoreductases; Bacterial Proteins; Binding Sites; Biopterins; Catalysis; Crystallography, X-Ray; Escherichia coli; GTP Cyclohydrolase; Guanosine Triphosphate; Models, Molecular; Neopterin; Phosphorus-Oxygen Lyases; Protein Conformation; Pteridines | 1995 |
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.
Topics: Amino Acid Oxidoreductases; Biopterins; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypoxanthines; Interferon-gamma; Lipopolysaccharides; Neopterin; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Tumor Necrosis Factor-alpha; Umbilical Veins | 1993 |
The effect of tetrahydrobiopterin on the in situ phosphorylation of tyrosine hydroxylase in rat striatal synaptosomes.
Topics: Animals; Biopterins; Bucladesine; Corpus Striatum; Ethers, Cyclic; Male; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Protein Phosphatase 2; Pteridines; Pterins; Rats; Rats, Sprague-Dawley; Synaptosomes; Tyrosine 3-Monooxygenase | 1994 |
6R-L-erythro-5,6,7,8-tetrahydrobiopterin: a regulator of neurotransmitter release.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Hippocampus; Infusions, Parenteral; Kinetics; Male; Methyltyrosines; Microdialysis; Pteridines; Pterins; Rats; Rats, Wistar; Reserpine; Stereoisomerism | 1993 |
Effect of pteridine derivatives on intracellular calcium concentration in human monocytic cells.
Topics: Biopterins; Calcium; Cell Line; Egtazic Acid; Humans; Lanthanum; Monocytes; Neopterin; Pteridines | 1993 |
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.
Topics: 3T3 Cells; Animals; Biopterins; Blotting, Northern; Blotting, Western; Cytosol; Dose-Response Relationship, Drug; Enzyme Induction; Genetic Engineering; Genetic Vectors; Humans; Mice; Nitric Oxide Synthase; Nitrites; Protein Conformation; Pteridines; Pterins; Recombinant Proteins; Retroviridae | 1995 |
Effects of depletion of intracellular tetrahydrobiopterin in murine erythroleukemia cells.
Topics: Acetamides; Alcohol Oxidoreductases; Animals; Biopterins; Cell Differentiation; Cell Division; Enzyme Inhibitors; Friend murine leukemia virus; G1 Phase; GTP Cyclohydrolase; Hemoglobins; Hypoxanthines; Leukemia, Erythroblastic, Acute; Mice; Phosphorylation; Pteridines; Retinoblastoma Protein; Tumor Cells, Cultured | 1996 |
Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells.
Topics: Arginine; Biopterins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Sugar Acids; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries.
Topics: Animals; Anions; Biopterins; Calcium; Cerebral Arteries; Culture Media; Cyclic GMP; Dogs; Endothelium, Vascular; In Vitro Techniques; Pteridines; Pterins; Superoxides; Vasodilation | 1996 |
Tetrahydrobiopterin loading test in xanthine dehydrogenase and molybdenum cofactor deficiencies.
Topics: Administration, Oral; Adult; Antioxidants; Biopterins; Child, Preschool; Coenzymes; Female; Heterozygote; Humans; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Metalloproteins; Middle Aged; Molybdenum Cofactors; Pregnancy; Pteridines; Pterins; Xanthine Dehydrogenase; Xanthopterin | 1996 |
Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin.
Topics: Animals; Biopterins; Endothelium, Vascular; Enzyme Inhibitors; Hemodynamics; Hypoxanthines; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Pteridines; Pterins; Reference Values; Swine; Vasodilation | 1996 |
Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites.
Topics: Animals; Binding Sites; Biopterins; Dimerization; Heme; In Vitro Techniques; Kinetics; Molecular Structure; Neurons; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Pteridines; Rats; Recombinant Proteins; Spectrophotometry | 1996 |
Effects of activating and deactivating cytokines on the functionally linked tetrahydrobiopterin. No pathways in vascular smooth muscle cells.
Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cytokines; Humans; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-4; Lipopolysaccharides; Muscle, Smooth, Vascular; Nitric Oxide; Pteridines; Pterins; Rats; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 1996 |
Modulation of adenovirus-mediated gene transfer by nitric oxide.
Topics: 3T3 Cells; Adenoviruses, Human; Animals; Antioxidants; beta-Galactosidase; Biopterins; Cell Survival; Cyclic GMP; Enzyme Inhibitors; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Humans; Luciferases; Lung; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Pteridines; Pterins; Transfection | 1997 |
Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin.
Topics: Animals; Biopterins; Dimerization; Electrophoresis, Polyacrylamide Gel; Heme; Kinetics; Macrophages; Mice; Nitric Oxide Synthase; Pteridines; Recombinant Proteins; Spectrophotometry | 1997 |
Pteridines in the control of pigmentation.
Topics: Adult; Biopterins; Exudates and Transudates; Female; GTP Cyclohydrolase; Humans; Male; Phenylalanine Hydroxylase; Pigmentation Disorders; Pteridines; Skin Diseases, Vesiculobullous; Time Factors; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 1997 |
Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content.
Topics: Animals; Biopterins; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Hypoxanthines; Nitric Oxide Synthase; Oxidative Stress; Pteridines; Pterins; Superoxides | 1997 |
Tetrahydrobiopterin modulates cyclooxygenase-2 expression in human mesangial cells.
Topics: Biopterins; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Methotrexate; NG-Nitroarginine Methyl Ester; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Pteridines; Pterins; Quinoxalines; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1997 |
Expression and function of recombinant endothelial NO synthase in coronary artery smooth muscle cells.
Topics: Adenoviridae; Animals; Biopterins; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Cyclic GMP; DNA Replication; Enzyme Induction; Genes, Reporter; Genetic Vectors; GTP Cyclohydrolase; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Recombinant Fusion Proteins; Superoxide Dismutase; Swine; Transfection | 1997 |
Modulation of inducible nitric oxide synthase mRNA stability by tetrahydrobiopterin in vascular smooth muscle cells.
Topics: Animals; Base Sequence; Biopterins; Cells, Cultured; Dicumarol; DNA Primers; Drug Stability; Gene Expression Regulation, Enzymologic; Kinetics; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Pteridines; Pterins; Rats; RNA, Messenger | 1998 |
Coexpression of GTP cyclohydrolase I and inducible nitric oxide synthase mRNAs in mouse osteoblastic cells activated by proinflammatory cytokines.
Topics: 3T3 Cells; Animals; Apoptosis; Biopterins; Cell Nucleus; Cell Survival; Curcumin; Cytokines; DNA Fragmentation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Hypoxanthines; Interferon-gamma; Interleukin-1; Kinetics; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoblasts; Penicillamine; Proline; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Thiocarbamates; Transcription Factor AP-1; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 1998 |
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.
Topics: Animals; Arginine; Biopterins; Cattle; Cells, Cultured; Endothelium, Vascular; Hydrogen Peroxide; Ionomycin; omega-N-Methylarginine; Pteridines; Pterins; Rats; Serotonin | 1998 |
Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death.
Topics: Animals; Aorta, Thoracic; Biopterins; Cattle; Cell Death; Cytokines; Endothelium, Vascular; Enzyme Induction; L-Lactate Dehydrogenase; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penicillamine; Pteridines; Pterins; S-Nitroso-N-Acetylpenicillamine; Serotonin | 1998 |
SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin.
Topics: Animals; Antioxidants; Aorta; Benzoates; Biopterins; Catalase; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Iron Chelating Agents; L-Lactate Dehydrogenase; Molsidomine; Nitric Oxide; Plant Extracts; Pteridines; Pterins; Reactive Oxygen Species; Superoxide Dismutase; Trypan Blue | 1999 |
Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase.
Topics: Arginine; Biopterins; Dimerization; Enzyme Stability; Escherichia coli; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Conformation; Pteridines; Recombinant Proteins; Spectrophotometry; Spermine | 1999 |
Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function.
Topics: Antioxidants; Biopterins; Endothelium, Vascular; Kinetics; Nitrates; Nitric Oxide Synthase; Oxidants; Oxidation-Reduction; Pteridines | 1999 |
Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: structure-activity relationship of antagonists of (6R)-5,6,7,8-tetrahydrobiopterin cofactor.
Topics: Animals; Biopterins; Enzyme Inhibitors; Isoenzymes; Neurons; Nitric Oxide Synthase; Pteridines; Structure-Activity Relationship; Swine | 1999 |
Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats: protective effect of tetrahydrobiopterin.
Topics: Animals; Antioxidants; Biopterins; Male; Nitric Oxide; Pteridines; Pterins; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Stomach | 2000 |
Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin.
Topics: Animals; Aorta; Arginine; Ascorbic Acid; Atrial Natriuretic Factor; Biopterins; Calcimycin; Cattle; Cell Line; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; Spodoptera; Swine; Transfection | 2000 |
Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin.
Topics: Animals; Antioxidants; Biopterins; Buthionine Sulfoximine; Cell Survival; Dopamine; Enzyme Inhibitors; Female; Glutathione; Glutathione Peroxidase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Parkinson Disease; Pregnancy; Pteridines; Pterins; Pyrazoles; Rats; Rats, Sprague-Dawley; tert-Butylhydroperoxide | 2000 |
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Chromatography, High Pressure Liquid; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Immunoblotting; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Isoforms; Pteridines; Pterins; Rats; Rats, Mutant Strains | 2000 |
Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging.
Topics: Aging; Animals; Animals, Newborn; Biopterins; Body Weight; Brain; Growth; Kidney; Liver; Mice; Mice, Inbred ICR; Organ Size; Pteridines | 2000 |
L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin.
Topics: Ascorbic Acid; Biopterins; Cells, Cultured; Citrulline; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; GTP Cyclohydrolase; Humans; Hypoxanthines; Nitric Oxide; Nitric Oxide Synthase; Phosphorus-Oxygen Lyases; Pteridines; Pterins; RNA, Messenger; Solutions; Umbilical Cord | 2001 |
Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis.
Topics: Acetylcholine; Animals; Arteriosclerosis; Atrial Appendage; Biopterins; Cholesterol; Coronary Vessels; Diet, Atherogenic; Dose-Response Relationship, Drug; Endothelium, Vascular; Histamine; Humans; In Vitro Techniques; Nitroprusside; Pteridines; Pterins; Serotonin; Substance P; Swine, Miniature; Vascular Resistance; Vasoconstriction; Vasodilation; Vasodilator Agents | 2000 |
Inhibition of endotoxin-induced vascular hyporeactivity by 4-amino-tetrahydrobiopterin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Biopterins; Bradykinin; Calcimycin; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Endotoxins; Enzyme Inhibitors; Hydrazines; In Vitro Techniques; Lipopolysaccharides; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Nitrogen Oxides; Norepinephrine; Pteridines; Pterins; Pulmonary Artery; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2000 |
Paracrine neuroprotective effect of nitric oxide in the developing retina.
Topics: Animals; Animals, Newborn; Anisomycin; Arginine; Biopterins; Cell Death; Cells, Cultured; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; NADPH Dehydrogenase; Neuroprotective Agents; Nitric Oxide; Paracrine Communication; Penicillamine; Pteridines; Pterins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine | 2001 |
The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species.
Topics: Antioxidants; Biopterins; Catalase; Cell Division; Cell Line; Cell Survival; Endothelium, Vascular; Free Radical Scavengers; Humans; In Vitro Techniques; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Pulmonary Artery; Reactive Oxygen Species; Superoxide Dismutase; Vehicle Emissions | 2001 |
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apolipoproteins E; Biopterins; Calcimycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Ionophores; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroglycerin; Pteridines; Pterins; Superoxides; Vasodilation; Vasodilator Agents | 2001 |
Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase.
Topics: Antioxidants; Biopterins; Catalysis; Electric Conductivity; Electrochemistry; Nitric Oxide Synthase; Oxidation-Reduction; Pteridines | 2001 |
Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?
Topics: Animals; Arginine; Biopterins; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Vessels; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Humans; Hypercholesterolemia; In Vitro Techniques; Infusions, Intra-Arterial; Ionophores; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pteridines; Pterins; Reactive Oxygen Species; Species Specificity; Substance P; Swine; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
Glucocorticoids inhibit tetrahydrobiopterin-dependent endothelial function.
Topics: Animals; Aorta, Thoracic; Biopterins; Dexamethasone; Endothelium, Vascular; Glucocorticoids; GTP Cyclohydrolase; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Phenylephrine; Pteridines; Pterins; Rats; Rats, Wistar; Vasoconstriction | 2001 |
Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function.
Topics: Acetylcholine; Animals; Aorta; Binding Sites; Biopterins; Cattle; Endothelium, Vascular; Fluorescent Dyes; Free Radicals; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pteridines; Pterins; Reactive Oxygen Species; Rhodamines; Superoxides; Tetrahydrofolates; Vasodilation | 2002 |
Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biopterins; Cell Movement; Graft Rejection; Kidney; Kidney Transplantation; Kinetics; Macrophages; Models, Biological; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pteridines; Pterins; Rats; Rats, Inbred Lew; Superoxides | 2002 |
Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin.
Topics: Animals; Animals, Newborn; Biopterins; Buthionine Sulfoximine; Coculture Techniques; Dopamine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutathione; Homovanillic Acid; Hypoxanthines; Neostriatum; Organ Culture Techniques; Oxidative Stress; Parkinson Disease; Pteridines; Pterins; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase | 2002 |
Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin.
Topics: Animals; Biopterins; Cell Fusion; Glucose; Hypoxanthines; Insulin; Insulin Secretion; Insulinoma; Interleukin-1; Islets of Langerhans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Pancreatic Neoplasms; Pteridines; Pterins; Rats; Tumor Cells, Cultured | 2002 |
Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major.
Topics: Amino Acid Sequence; Animals; Biopterins; Humans; Leishmania major; Molecular Sequence Data; Open Reading Frames; Oxidoreductases; Protozoan Proteins; Pteridines; Recombinant Proteins; Sequence Alignment; Trypanosoma brucei brucei | 2002 |
Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants.
Topics: Acetylcholine; Acetylcysteine; Animals; Antioxidants; Aorta, Thoracic; Arteriosclerosis; Biopterins; Calcimycin; Cholesterol; Diet; Endothelium, Vascular; Free Radical Scavengers; Hyperlipidemias; Ionophores; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Pteridines; Pterins; Rabbits; Sulfhydryl Compounds; Vasodilator Agents | 2002 |
Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin.
Topics: Acetylcholine; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biopterins; Blotting, Western; Catecholamines; Cells, Cultured; Ciliary Neurotrophic Factor; Dopamine; Foot; Mice; Neurons; Neurotransmitter Agents; Norepinephrine; Phenotype; Pteridines; Pterins; Skin; Sweat Glands; Sympathetic Fibers, Postganglionic; Tissue Extracts; Tyrosine 3-Monooxygenase | 2002 |
Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin.
Topics: Acetylcholine; Animals; Aorta; Biopterins; Culture Techniques; Dithiothreitol; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Nitric Oxide Synthase; Nitroarginine; Pteridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Reducing Agents; Vasoconstriction; Vasodilation | 2003 |
Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biopterins; Cell Count; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Dopamine; Dose-Response Relationship, Drug; Electron Transport Complex I; Hypoxanthines; In Vitro Techniques; L-Lactate Dehydrogenase; NADH, NADPH Oxidoreductases; Neurons; Neuroprotective Agents; Nomifensine; Propidium; Pteridines; Pterins; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase | 2003 |
Regulation of tyrosinase by tetrahydropteridines and H2O2.
Topics: Binding Sites; Biopterins; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Monophenol Monooxygenase; Oxidation-Reduction; Protein Binding; Pteridines; Tyrosine | 2004 |
Regulation of tyrosinase by tetrahydropteridines--what is real? A comment on the work published by Wood et al. on December 24, 2004.
Topics: Animals; Binding Sites; Biopterins; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Monophenol Monooxygenase; Oxidation-Reduction; Protein Binding; Pteridines; Tyrosine | 2005 |
Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
Topics: Animals; Binding Sites; Biopterins; Crystallography, X-Ray; Humans; Isoenzymes; Ligands; Models, Molecular; Molecular Structure; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Structure, Tertiary; Pteridines; Rats; Structure-Activity Relationship | 2005 |
Pigment pattern formation in the quail mutant of the silkworm, Bombyx mori: parallel increase of pteridine biosynthesis and pigmentation of melanin and ommochromes.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Base Sequence; Biopterins; Bombyx; Cytoplasmic Granules; GTP Cyclohydrolase; Integumentary System; Larva; Melanins; Microfilament Proteins; Molecular Sequence Data; Mutant Proteins; Phenothiazines; Pigmentation; Pigments, Biological; Pteridines; RNA, Messenger | 2006 |
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.
Topics: Animals; Biopterins; Drug Resistance; Folic Acid; Hydrogen Peroxide; Leishmania major; Methylnitronitrosoguanidine; Molsidomine; Multienzyme Complexes; Mutation; Nitric Oxide Donors; Nitroso Compounds; Oxidants; Oxidoreductases; Protozoan Proteins; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2009 |
Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method.
Topics: Adult; Biomarkers; Biopterins; Child; Chromatography, High Pressure Liquid; Female; Fluorescent Dyes; Humans; Infectious Mononucleosis; Male; Phenylketonurias; Pteridines | 2009 |
Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
Topics: Biomarkers; Biopterins; Dihydropteridine Reductase; GTP Cyclohydrolase; Humans; Hydro-Lyases; Infant, Newborn; Metabolism, Inborn Errors; Neonatal Screening; Phenylalanine; Phenylketonurias; Predictive Value of Tests; Prognosis; Pteridines | 2010 |
The tetrahydrobiopterin pathway: a novel target for the treatment of depression.
Topics: Antidepressive Agents; Biopterins; Depressive Disorder; Humans; Metabolic Networks and Pathways; Norepinephrine; Pteridines; Serotonin | 2011 |
HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation.
Topics: Biopterins; Chromatography, High Pressure Liquid; Electrochemistry; Fluorometry; Oxidation-Reduction; Pteridines | 2012 |