pteridines and sapropterin

pteridines has been researched along with sapropterin in 211 studies

Research

Studies (211)

TimeframeStudies, this research(%)All Research%
pre-1990123 (58.29)18.7374
1990's48 (22.75)18.2507
2000's35 (16.59)29.6817
2010's5 (2.37)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eldridge, R; Levine, R; Lovenberg, W; Paulson, G; Williams, A1
Ayling, JE; Bailey, SW1
Abelson, HT; Fosburg, M; Gorka, C; Spector, R1
Abelson, HT; Fosburg, M; Levy, P; Spector, R1
Bartholomé, K; Bieri, JH; Curtius, HC; Däumling, S; Niederwieser, A; Schaub, J; Schircks, B; Viscontini, M1
Bybee, JA; Gál, EM; Sherman, AD1
Stone, KJ1
Gross, SS; Levi, R1
Bult, H; Herman, AG; Jorens, PG; van Overveld, FJ; Vermeire, PA1
Blaskovics, M; Blau, N; Curtius, HC; Giudici, T; Kierat, L1
Bel, Y; Ferré, J; Jacobson, KB1
Bigham, EC; Duch, DS; Edelstein, MP; Smith, GK1
Gross, SS; Jaffe, EA; Kilbourn, RG; Levi, R1
Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G2
Dhondt, JL3
Kapatos, G; Kaufman, S; Levine, RA; Milstien, S1
Bacher, A; Kerler, F; Schmid, C; Ziegler, I1
Donlon, J; Walsh, GA1
Curtius, HC; Dahinden, R; Ghisla, S; Kuster, T; Leimbacher, W; Raschdorf, F; Richter, WJ; Steinerstauch, P1
Perez-Polo, JR; Shen, RS; Zhang, YX1
Bacher, A; Katzenmaier, G; Kerler, F; Le Van, Q; Schmid, C; Schwarzkopf, B; Ziegler, I1
Goldberg, A; McIntosh, MJ; Meredith, PA; Moore, MR1
Fleischhacker, WW; Meise, U; Schubert, H1
Duch, DS; Nichol, CA; Smith, GK1
Watts, RW1
Abou-Donia, MM; Iuvone, PM; Nichol, CA; Reinhard, JF; Viveros, OH1
Katoh, S; Sueoka, T2
Abou-Donia, MM; Nichol, CA; Viveros, OH; Wilson, SP; Zimmerman, TP1
Aloi, J; Insel, T; Linnoila, M; Lovenberg, W; Miller, L; Murphy, DL; Scheinin, M1
Curtius, HC; Heintel, D; Leimbacher, W; Redweik, U; Zagalak, B1
Chandrasurin, P; Cichetti, JA; Nichol, CA; Smith, GK1
Curtius, HC; Leimbacher, W; Leupold, D; Niederwieser, A; Ponzone, A; Rey, F1
Abou-Donia, MA; Duch, DS; Edelstein, MP; Nichol, CA; Viveros, OH; Woolf, JH1
Cotton, RG1
Bowers, SW; Duch, DS1
Bacher, A; Katzenmeier, G; Le Van, Q; Schmid, C; Schwarzkopf, B1
Smith, GK1
Alam, A; Shen, RS; Zhang, YX1
Bosshard, R; Leimbacher, W; Neuheiser, F; Redweik, U; Zagalak, B1
Blair, JA; Heales, SJ; Meinschad, C; Ziegler, I1
Ellwart, J; Schwulera, U; Ziegler, I1
Howells, DW; Hyland, K; Smith, I1
Burns, RS; Eldridge, R; Levine, RA; LeWitt, PA; Lovenberg, W; Miller, LP; Newman, RP; Papavasiliou, A; Rayes, A1
Abarca, J; Daniels, AJ; Lista, A; Ramos, C1
Gustmann, H; Koke, HG; Manzke, H; Nyhan, WL1
Barford, PA; Blair, JA; Hamon, CG1
Boudha, A; Dhondt, JL; Farriaux, JP; Largillière, C; Leeming, RJ; Ringel, J; Roger, MM1
Lee, EH; Mandell, AJ1
Blonder, J; Cohen, BE; Normand, M; Peled, I; Quint, J; Szeinberg, A1
Müller, WJ; Schwuléra, U; Sonneborn, HH; Ziegler, I1
Cotlier, E; Rao, GN1
Akino, M; Katoh, S; Masada, M; Sueoka, T1
Curtius, HC; Ghisla, S; Heintel, D; Kuster, T; Leimbacher, W; Niederwieser, A2
Kaufman, S1
Curtius, HC; Niederwieser, A; Ponzone, A1
Hyland, K; Kendall, B; Smith, I1
Güttler, F; Lou, HC; Lykkelund, C; Niederwieser, A; Rasmussen, V1
Howells, D; Hyland, K; Leonard, J; Smith, I1
Nichol, CA; Smith, GK3
Storm, CB; Williams, TC1
Hayaishi, O; Miwa, S; Watanabe, Y1
Kaufman, S; Milstien, S2
Benkovic, SJ; Bollag, GE; Dix, TA; Domanico, PL1
Blair, J; Hagberg, B; Leeming, R; Sahota, A1
Abou-Donia, MM; Viveros, OH1
Kato, T; Matsuura, S; Nagatsu, T; Oka, K; Sugimoto, T1
Levine, RA; Lovenberg, W; Miller, LP1
Leeming, RJ1
Mandell, AJ; Russo, PV2
Blair, JA; Hilburn, ME; Leeming, RJ; McIntosh, MJ; Moore, MR1
Bellahsene, Z; Dhondt, JL; Noël, C; Vanhille, P1
Angst, J; Curtius, HC; Levine, RA; Lovenberg, W; Niederwieser, A; Woggon, B1
Abou-Donia, MM; Duch, DS; Nichol, CA; Viveros, OH1
Ballenger, JC; Gold, PW; Kellner, CH; Post, RM; Rakita, RM; Rubinow, DA1
Kapatos, G; Kaufman, S; Rizzo, WB; Schulman, JD; Tamarkin, L; Van Loon, GR1
Hirata, Y; Iizuka, R; Kondo, T; Nagatsu, I; Nagatsu, T; Narabayashi, H; Oka, K; Rahman, MK; Trocewicz, J; Yamaguchi, T1
Levine, RA; Lovenberg, W1
Barford, PA; Blair, JA; Coppen, A; Hamon, CG; Leeming, RJ; Morar, C; Pheasant, AE; Reynolds, GP; Whitburn, SB1
Culvenor, AJ; Lovenberg, W; Zabrenetzky, V1
Berlow, S; Hoganson, G; Kaufman, S; Matalon, R; Milstien, S; Naylor, E; Schuett, V; Seifert, W1
Angst, J; Curtius, HC; Niederwieser, A; Woggon, B1
Aziz, AA; Blair, JA; Leeming, RJ; Sylvester, PE1
Curtius, HC; Niederwieser, A1
Harpey, JP1
Curtius, HC; Leeming, RJ; Niederwieser, A; Rey, F; Rey, J; Saudubray, JM1
Burns, RS; Calne, DB; Insel, T; Levine, RA; LeWitt, PA; Lovenberg, W; Miller, LP; Newman, RP1
Brown, GM; Primus, JP; Switchenko, AC1
Lipson, A; O'Halloran, M; Potter, M; Wilken, B; Yu, J1
Güttler, F; Lou, H; Lykkelund, C; Niederwieser, A1
Døskeland, AP; Døskeland, SO; Flatmark, T; Ogreid, D1
Chao, JY; Duch, DS; Edelstein, MP; Lee, CL; Nichol, CA1
Davidson, JR; Duch, DS; Garbutt, JC; Nichol, CA; Woolf, JH1
Armarego, WL; Randles, D; Taguchi, H1
Blair, JA; Leeming, RJ; Melikian, V1
Beck, B1
Combs, AB; Folkers, K; Kappel, M; Lewandowski, E; Vadhanavikit, S1
Bräutigam, M; Dreesen, R; Herken, H2
Curtius, HC; Levine, R; Müldner, H; Niederwieser, A1
Barford, PA; Blair, JA; Leeming, RJ; Smith, I1
Kaufman, S; Phillips, RS1
Matalon, R1
Webber, S; Whiteley, JM1
Atarés, M; Blau, N; Cardesa-Garcia, J; Joller, P; Niederwieser, A; Wang, M1
Barford, PA; Blair, JA; Eggar, C; Hamon, C; Morar, C; Whitburn, SB1
Curtius, HC; Endres, W; Niederwieser, A; Ohrt, B; Schaub, J; Wang, M1
Hase, Y; Iwai, K; Kobashi, M; Oura, T; Shintaku, H; Turuhara, T1
Kapatos, G; Kaufman, S; Klein, DC; Weller, JL1
Eldridge, R; LeWitt, PA; Lovenberg, W; Miller, LP; Newman, RP1
Duch, DS; Edelstein, MP; Lee, CL; Nichol, CA1
Blair, JA; Leeming, RJ; Morar, C; Whitburn, SB; Wilcock, GK1
Blair, JA; Brown, SM; Leeming, RJ1
Delcroix, M; Dhondt, JL; Farriaux, JP1
Ballenger, J; Bunney, WE; Garbutt, JC; Levine, RA; Lovenberg, WM; Murphy, DL; Sternberg, DE; van Kammen, DP1
Hirayama, K; Katoh, S; Masuda, I; Nakanishi, N; Sueoka, T; Yamada, S1
Dhondt, JL; Farriaux, JP2
Narisawa, K; Tada, K1
Curtius, HC; Leupold, D; Niederwieser, A; Wang, M1
Kapatos, G; Kaufman, S; McInnes, RR; Rizzo, WB; Schulman, JD1
Bräutigam, M; Dreesen, R1
Barr, DG; Westwood, A1
Ballenger, J; Calne, D; Levine, R; Lovenberg, W; Williams, A1
Kapatos, G; Kaufman, S1
Kato, T; Matsuura, S; Nagatsu, T; Sugimoto, T; Yamaguchi, T1
Knapp, S; Mandell, AJ1
Cotton, RG; Danks, DM1
Hasegawa, H; Ichiyama, A; Imaizumi, S; Matsuura, S; Sugimoto, T1
Gross, SS; Hattori, Y; Levi, R; Madera, A; Park, KH; Vane, J1
Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G1
Klatt, P; Leopold, E; Mayer, B; Schmid, M; Schmidt, K; Werner, ER1
Koshimura, K; Miwa, S; Watanabe, Y1
Mühl, H; Pfeilschifter, J1
Bachus, KE; Dittman, WA; Mason, SN; McDonald, B; Misukonis, MA; Sauls, DL; Shami, PJ; Smith, GK; Weinberg, JB; Wood, ER1
Bacher, A; Huber, R; Meining, W; Nar, H; Schmid, C; Weinkauf, S1
Fuchs, D; Hausen, A; Reibnegger, G; Schmidt, K; Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G1
Kaufman, S; Ribeiro, P1
Koshimura, K; Miwa, S; Ohue, T; Watanabe, Y1
Fuchs, D; Lang, F; Wachter, H; Weiss, G; Wöll, E1
Billiar, TR; Loftus, M; Robbins, PD; Stuehr, DJ; Tzeng, E1
Mayer, B; Wachter, H; Werner, ER; Werner-Felmayer, G1
Fan, S; Kaufman, S; Zhuo, S1
Cañada, FJ; Lamas, S; Pérez-Sala, D; Saura, M1
Katusic, ZS; Milstien, S; Tsutsui, M1
Blau, N; de Klerk, JB; Duran, M; Heizmann, CW; Kierat, L; Smeitink, JA; Thöny, B1
Chilian, WM; DeFily, DV; Mitchell, M; Tiefenbacher, CP1
Gorren, AC; Hemmens, B; List, BM; Mayer, B; Pitters, E; Schmidt, K; Schrammel, A; Werner, ER1
Blau, N; Kierat, L; Schaffner, A; Schoedon, G; Walter, R1
Garver, RI; Haddad, IY; Hong, J; Matalon, S; Sorscher, EJ; Tzeng, E1
Clark, P; Gorren, AC; Mayer, B; Pfeiffer, S; Schmidt, K; Stuehr, DJ; Werner, ER; Wu, C1
Beazley, W; Bünz, A; Körner, C; Schallreuter, KU; Schulz-Douglas, V1
Ishii, M; Kuroiwa, Y; Momose, K; Shimizu, S; Yamamoto, T1
Díaz-Cazorla, M; Jiménez, W; Lamas, S; Pérez-Sala, D; Ros, J1
Fitzpatrick, LA; Katusic, ZS; Kullo, IJ; Milstien, S; O'Brien, T; Pompili, VJ; Schwartz, RS; Tsutsui, M1
Linscheid, P; Schaffner, A; Schoedon, G1
Arai, M; Kondo, A; Mogi, M; Nagatsu, T; Togari, A1
Ishii, M; Momose, K; Shimizu, S; Yamamoto, T2
Ishii, M; Kawakami, Y; Momose, K; Shimizu, S; Yamamoto, T1
Ichinose, H; Nagatsu, T1
Bömmel, HM; Frey, A; Fröhlich, LG; Kotsonis, P; Pfleiderer, W; Reif, A; Schmidt, HH; Wink, DA1
Katusic, Z; Milstien, S1
Al-Masoudi, N; Fröhlich, LG; Hofmann, H; Kotsonis, P; Matter, H; Pfleiderer, W; Schmidt, HH; Strobel, H; Taghavi-Moghadam, S; Traub, H1
Ishii, M; Kiuchi, Y; Nawata, S; Shimizu, S; Yamamoto, T1
Huang, A; Keaney, JF; Venema, RC; Vita, JA1
Kang, UJ; Kowlessur, D; Lei, XG; Milstien, S; Nakamura, K; Wiatr, T; Wright, DA1
Hatakeyama, K; Kelly, KA; Marinos, RS; Martinez-Zaguilan, R; Meininger, CJ; Rojas, JD; Wu, G1
Eda, S; Masada, M; Yoshida, YI1
Heller, R; Mayer, B; Schellenberg, B; Unbehaun, A; Werner, ER; Werner-Felmayer, G1
Amann, K; Bleeke, T; Kübler, W; Tiefenbacher, CP; Vahl, C; Vogt, A1
Dittrich, P; Gibraeil, HD; Mayer, B; Saleh, S1
Assreuy, J; Guimarães, C; Linden, R1
Bai, Y; Sagai, M; Suzuki, AK1
Freeman, BA; Fukai, T; Harrison, DG; Kurz, S; Laursen, JB; McCann, L; Somers, M; Tarpey, M; Warnholtz, A1
Gorren, AC; Kungl, AJ; Mayer, B; Schmidt, K; Werner, ER1
Tiefenbacher, CP1
Dorrance, AM; Johns, DG; Tramontini, NL; Webb, RC1
Beazley, WD; Rokos, H; Schallreuter, KU1
Gorren, AC; Mayer, B1
Oettl, K; Reibnegger, G1
Anderson, TJ; Hyndman, ME; Parsons, HG; Rosenfeld, RJ; Verma, S1
Gröne, HJ; Huisman, A; Joles, JA; Martasek, P; Rabelink, TJ; van Faassen, EE; van Zonneveld, AJ; Vanin, AF; Vos, I1
Gramsbergen, JB; Kornblit, B; Møller Dall, A; Sandberg, M; Zimmer, J1
Cunningham, JM; Stickings, P1
Beverley, SM; Cunningham, ML; Lye, LF1
Tarpey, MM1
Duquaine, D; Kalyanaraman, B; Rajagopalan, S; Vásquez-Vivar, J; Whitsett, J1
Habecker, BA; Klein, MG; Li, W; Sundgren, NC; Woodward, WR1
Félétou, M; Levens, N; Vanhoutte, PM; Yang, D; Zhang, JN1
Gramsbergen, JB; Hesslinger, C; Jansen, P; Madsen, JT; Meyer, M; Zimmer, J1
Kashiwagi, A; Masada, M; Okamura, T; Shinozaki, K1
Kotsonis, P; Matter, H1
Chavan, B; Hafeez, I; Schallreuter, KU; Wood, JM1
Wojtasek, H1
Fedorov, R; Frey, A; Fröhlich, LG; Ghosh, DK; Hartmann, E; Kotsonis, P; Kumar, HS; Matter, H; Pfleiderer, W; Reif, A; Scheurer, P; Schlichting, I; Schmidt, HH1
Kato, T; Mase, K; Nakagoshi, M; Sawada, H; Yamamoto, T1
Beverley, SM; Garraway, LA; Nare, B; Vickers, TJ1
Cañada-Cañada, F; Espinosa-Mansilla, A; Mancha de Llanos, A; Muñoz de la Peña, A1
McHugh, PC1
Ambrosio, G; Biondi, R; Capodicasa, E; De Pascali, F; Druhan, LJ; Hemann, C; Tritto, I; Zweier, JL1
Suckling, CJ1
Jayaraman, A; Nawaz, KA; Palaniswamy, M; Priyadarsini, U; Sabarathinam, S; Thandeeswaran, M1

Reviews

19 review(s) available for pteridines and sapropterin

ArticleYear
Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.
    Annual review of biochemistry, 1985, Volume: 54

    Topics: Alcohol Oxidoreductases; Animals; Biopterins; Body Fluids; Coenzymes; GTP Cyclohydrolase; Humans; Immune System Diseases; Mental Disorders; Metalloproteins; Molybdenum; Molybdenum Cofactors; Neoplasms; Nervous System Diseases; Phenylalanine; Phenylketonurias; Pteridines; Pterins; Tetrahydrofolate Dehydrogenase; Tissue Distribution; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase

1985
Defects of tetrahydrobiopterin synthesis and their possible relationship to a disorder of purine metabolism (the Lesch-Nyhan syndrome).
    Advances in enzyme regulation, 1985, Volume: 23

    Topics: Biopterins; Brain; Dopamine; GTP Cyclohydrolase; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Nervous System Diseases; Neurotransmitter Agents; Pteridines; Pterins; Purines

1985
Pteridines and mono-amines: relevance to neurological damage.
    Postgraduate medical journal, 1986, Volume: 62, Issue:724

    Topics: Amines; Biopterins; Folic Acid; Humans; Nervous System; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines

1986
Biosynthesis of tetrahydrobiopterin in man.
    Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 1

    Topics: Alcohol Oxidoreductases; Biopterins; Deuterium; Humans; In Vitro Techniques; Liver; Neopterin; Pteridines; Tetrahydrofolate Dehydrogenase

1985
The role of tetrahydrobiopterin in neurological disease: a review.
    Journal of mental deficiency research, 1981, Volume: 25 Pt 4

    Topics: Aluminum; Biopterins; Brain; Dementia; Humans; Lead Poisoning; Nervous System Diseases; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Pteridines

1981
Tetrahydrobiopterin deficiencies: preliminary analysis from an international survey.
    The Journal of pediatrics, 1984, Volume: 104, Issue:4

    Topics: Adjuvants, Pharmaceutic; Alcohol Oxidoreductases; Amino Acid Metabolism, Inborn Errors; Biopterins; Female; Folic Acid; GTP Cyclohydrolase; Humans; Infant; Infant, Newborn; Male; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Pteridines

1984
[Tetrahydroblopterin. Metabolism and metabolic role of unconjugated pteridines (author's transl)].
    Pathologie-biologie, 1980, Volume: 28, Issue:6

    Topics: Animals; Biological Transport; Biopterins; Cattle; Humans; Mice; Mixed Function Oxygenases; Neoplasms; Neurotic Disorders; Oxidation-Reduction; Phenylalanine; Phenylketonurias; Pteridines; Rats

1980
[Biogenic amines and hyperphenylalaninemia (author's transl)].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1981, Volume: 26, Issue:11

    Topics: Biogenic Amines; Biopterins; Dihydropteridine Reductase; Humans; Infant; Mass Screening; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines

1981
Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate-limiting for nitric oxide production.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Amino Acid Oxidoreductases; Animals; Aorta; Biopterins; Enzyme Induction; Gene Expression; GTP Cyclohydrolase; Kinetics; Lipopolysaccharides; Models, Biological; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Rats; RNA, Messenger

1993
Modulation of nitric oxide synthase activity in intact cells by intracellular tetrahydrobiopterin levels.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Cells, Cultured; Cytokines; Endothelium, Vascular; Enzyme Induction; Fibroblasts; Humans; Mice; Models, Biological; Nitric Oxide Synthase; Pteridines; Pterins; Umbilical Veins

1993
Biosynthesis of nitric oxide: dependence on pteridine metabolism.
    Reviews of physiology, biochemistry and pharmacology, 1996, Volume: 127

    Topics: Animals; Biopterins; Coenzymes; Guanylate Cyclase; Humans; Iron; Mixed Function Oxygenases; Nitric Oxide; Nitric Oxide Synthase; Pteridines

1996
Regulation of pteridine-requiring enzymes by the cofactor tetrahydrobiopterin.
    Molecular neurobiology, 1999, Volume: 19, Issue:1

    Topics: Amino Acid Sequence; Animals; Biopterins; Coenzymes; Enzyme Activation; Enzymes; Humans; Metabolism, Inborn Errors; Molecular Sequence Data; Pteridines

1999
Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines.
    Current drug metabolism, 2002, Volume: 3, Issue:2

    Topics: Animals; Antioxidants; Biopterins; Humans; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Pteridines

2002
Pteridine derivatives as modulators of oxidative stress.
    Current drug metabolism, 2002, Volume: 3, Issue:2

    Topics: Animals; Biopterins; Free Radical Scavengers; Humans; Oxidation-Reduction; Oxidative Stress; Pteridines; Pterins

2002
Sepiapterin treatment in atherosclerosis.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Oct-01, Volume: 22, Issue:10

    Topics: Animals; Arteriosclerosis; Biopterins; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pteridines; Pterins

2002
Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.
    Journal of pharmacological sciences, 2003, Volume: 91, Issue:3

    Topics: Administration, Oral; Animals; Antioxidants; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Humans; Insulin; Insulin Resistance; Muscle Relaxation; Nitric Oxide Synthase; Oxidative Stress; Pteridines

2003
Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents.
    Medicinal research reviews, 2004, Volume: 24, Issue:5

    Topics: Animals; Arginine; Binding Sites; Biopterins; Brain Ischemia; Enzyme Inhibitors; Humans; Inflammation; Isoenzymes; Neurodegenerative Diseases; Nitric Oxide Synthase; Protein Conformation; Pteridines; Quantitative Structure-Activity Relationship; Sepsis; Structure-Activity Relationship

2004
The diversity-oriented synthesis of pteridines - achievements and potential for development.
    IUBMB life, 2013, Volume: 65, Issue:4

    Topics: Biopterins; Carbon; Combinatorial Chemistry Techniques; Drug Design; Halogens; Humans; Molecular Structure; Pteridines; Tetrahydrofolates

2013
Characterization of unexplored amidohydrolase enzyme-pterin deaminase.
    Applied microbiology and biotechnology, 2016, Volume: 100, Issue:11

    Topics: Amidohydrolases; Aminohydrolases; Animals; Biopterins; Eukaryotic Cells; Prokaryotic Cells; Pteridines

2016

Trials

4 trial(s) available for pteridines and sapropterin

ArticleYear
Re-evaluation of antidepressant effect of tetrahydrobiopterin.
    Lancet (London, England), 1985, Aug-17, Volume: 2, Issue:8451

    Topics: Aged; Antidepressive Agents; Biopterins; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Pteridines

1985
Unsuccessful treatment of depression with tetrahydrobiopterin.
    Lancet (London, England), 1984, Dec-22, Volume: 2, Issue:8417-8418

    Topics: Biopterins; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electroconvulsive Therapy; Female; Humans; Pteridines

1984
Atypical phenylketonuria due to biopterin deficiency. Early treatment with tetrahydrobiopterin and neurotransmitter precursors, trials of monotherapy.
    Helvetica paediatrica acta, 1982, Volume: 37, Issue:5

    Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Clinical Trials as Topic; Humans; Infant; Levodopa; Male; Phenylketonurias; Pteridines

1982
Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid.
    Biochemical and biophysical research communications, 2002, Apr-12, Volume: 292, Issue:4

    Topics: Biopterins; Catalase; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Epidermis; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxidative Stress; Oxygen; Photochemistry; Pteridines; Pterins; Ultraviolet Rays; Vitiligo

2002

Other Studies

188 other study(ies) available for pteridines and sapropterin

ArticleYear
Low CSF hydroxylase cofactor (tetrahydrobiopterin) levels in inherited dystonia.
    Lancet (London, England), 1979, Aug-25, Volume: 2, Issue:8139

    Topics: Biopterins; Child; Dystonia; Female; Humans; Pteridines

1979
Separation and properties of the 6-diastereoisomers of l-erythro-tetrahydrobiopterin and their reactivities with phenylalanine hydroxylase.
    The Journal of biological chemistry, 1978, Mar-10, Volume: 253, Issue:5

    Topics: Biopterins; Chromatography, High Pressure Liquid; Circular Dichroism; Molecular Conformation; Phenylalanine Hydroxylase; Pteridines; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship

1978
Kinetics of tetrahydrobiopterin synthesis by rabbit brain dihydrofolate reductase.
    The Biochemical journal, 1978, Apr-01, Volume: 171, Issue:1

    Topics: Animals; Biopterins; Brain; Kinetics; Phenylalanine Hydroxylase; Pteridines; Rabbits; Tetrahydrofolate Dehydrogenase

1978
Tetrahydrobiopterin synthesis by rabbit brain dihydrofolate reductase.
    Journal of neurochemistry, 1978, Volume: 30, Issue:4

    Topics: Animals; Biopterins; Brain; Pteridines; Rabbits; Substrate Specificity; Tetrahydrofolate Dehydrogenase

1978
Tetrahydrobiopterin therapy of atypical phenylketonuria due to defective dihydrobiopterin biosynthesis.
    Archives of disease in childhood, 1978, Volume: 53, Issue:8

    Topics: Biopterins; Female; Humans; Infant; Phenylalanine; Phenylketonurias; Pteridines

1978
Biopterin. V. De novo synthesis of dihydrobiopterin: evidence for its quinonoid structure and lack of dependence of its reduction to tetrahydrobiopterin on dihydrofolate reductase.
    Journal of neurochemistry, 1979, Volume: 32, Issue:1

    Topics: Animals; Biopterins; Brain; Chromatography, Gas; Pteridines; Quinones; Rats; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Tissue Distribution

1979
The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats.
    The Biochemical journal, 1976, Jul-01, Volume: 157, Issue:1

    Topics: Animals; Biopterins; Female; Folic Acid Antagonists; Kinetics; Liver; Pteridines; Rats; Tetrahydrofolate Dehydrogenase; Trimethoprim

1976
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
    The Journal of biological chemistry, 1992, Dec-25, Volume: 267, Issue:36

    Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Biopterins; Cells, Cultured; Cytosol; Hypoxanthines; Interferon-gamma; Kinetics; Lipopolysaccharides; Male; Methotrexate; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen Consumption; Pteridines; Pterins; Rats; Rats, Inbred F344; Recombinant Proteins

1992
Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Cells, Cultured; Citrulline; Hypoxanthines; Interferon-gamma; Macrophages, Alveolar; Male; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Rats; Rats, Wistar; Recombinant Proteins

1992
Hyperphenylalaninaemia presumably due to carbinolamine dehydratase deficiency: loading tests with pterin derivatives.
    Journal of inherited metabolic disease, 1992, Volume: 15, Issue:3

    Topics: Biopterins; Female; Humans; Hydro-Lyases; Infant, Newborn; Kinetics; Phenylalanine; Pteridines; Pterins

1992
A comparative study of Drosophila phenylalanine hydroxylase with a natural and a synthetic tetrahydropterin as cofactor.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1992, Volume: 103, Issue:3

    Topics: Animals; Biopterins; Coenzymes; Drosophila melanogaster; Kinetics; Phenylalanine Hydroxylase; Pteridines; Pterins; Substrate Specificity

1992
New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines.
    The Journal of biological chemistry, 1992, Mar-15, Volume: 267, Issue:8

    Topics: Alcohol Oxidoreductases; Biopterins; Cell Division; Cell Line; Humans; Kinetics; Models, Molecular; Molecular Conformation; Molecular Structure; Pteridines; Pterins; Pyrimidines; Serotonin; Structure-Activity Relationship

1992
Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages.
    Biochemical and biophysical research communications, 1991, Aug-15, Volume: 178, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Calmodulin; Cells, Cultured; Cycloheximide; Cytokines; Endothelium, Vascular; Interferon-gamma; Isoenzymes; Kinetics; Macrophage Activation; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Recombinant Proteins; Tumor Necrosis Factor-alpha

1991
Relationships between pteridine synthesis and tryptophan degradation.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Biopterins; Cells, Cultured; Enzyme Induction; Humans; Hydrolases; Interferon-gamma; Macrophages; NAD; Neopterin; Pteridines; Tryptophan; Tryptophan Oxygenase

1991
Strategy for the screening of tetrahydrobiopterin deficiency among hyperphenylalaninaemic patients: 15-years experience.
    Journal of inherited metabolic disease, 1991, Volume: 14, Issue:2

    Topics: Belgium; Biopterins; Czechoslovakia; Diagnosis, Differential; Dihydropteridine Reductase; France; Humans; Infant, Newborn; Liver; Neonatal Screening; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Portugal; Prospective Studies; Pteridines; Retrospective Studies

1991
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.
    The Journal of experimental medicine, 1990, Dec-01, Volume: 172, Issue:6

    Topics: Animals; Biopterins; Cells, Cultured; Cytokines; Fibroblasts; Interferon-gamma; Interleukin-1; Kinetics; Methotrexate; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Pteridines; Pterins; Recombinant Proteins; Skin; Sugar Acids; Tumor Necrosis Factor-alpha

1990
Immunological evidence for the requirement of sepiapterin reductase for tetrahydrobiopterin biosynthesis in brain.
    Journal of neurochemistry, 1990, Volume: 54, Issue:4

    Topics: Alcohol Oxidoreductases; Animals; Biopterins; Blotting, Western; Brain; Chemical Phenomena; Chemistry; Electrophoresis, Gel, Two-Dimensional; Immunoblotting; Pteridines; Rats

1990
Synthesis of tetrahydrobiopterin in Friend erythroleukemia cells and its modulator effect on cell proliferation.
    Experimental cell research, 1990, Volume: 189, Issue:2

    Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cell Division; Clone Cells; Dimethyl Sulfoxide; DNA Replication; Enzyme Induction; GTP Cyclohydrolase; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phenylalanine Hydroxylase; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Tumor Cells, Cultured

1990
Dexamethasone and phenylalanine hydroxylase activities in rats.
    Biochemical Society transactions, 1990, Volume: 18, Issue:2

    Topics: Animals; Biopterins; Dexamethasone; Liver; Male; Phenylalanine Hydroxylase; Pteridines; Rats; Rats, Inbred Strains

1990
1H-NMR and mass spectrometric studies of tetrahydropterins. Evidence for the structure of 6-pyruvoyl tetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin.
    European journal of biochemistry, 1990, Feb-14, Volume: 187, Issue:3

    Topics: Alcohol Oxidoreductases; Biopterins; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Neopterin; Oxidation-Reduction; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Stereoisomerism

1990
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
    Journal of enzyme inhibition, 1989, Volume: 3, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animals; Biopterins; Cell Line; Colforsin; Cycloheximide; Dihydropteridine Reductase; GTP Cyclohydrolase; Isoenzymes; Kinetics; Pheochromocytoma; Pteridines; Pterins; Rats; Reserpine; Theophylline

1989
Biosynthesis of tetrahydrobiopterin: a sensitive assay of 6-pyruvoyltetrahydropterin synthase using [2'-3H]dihydroneopterin 3'-triphosphate as substrate.
    Biochimica et biophysica acta, 1989, Jan-27, Volume: 990, Issue:1

    Topics: Adsorption; Alcohol Oxidoreductases; Animals; Biopterins; Charcoal; Chemical Phenomena; Chemistry; Edetic Acid; Escherichia coli; Liver; Magnesium; Mice; Neopterin; Phosphorus-Oxygen Lyases; Pteridines; Tritium

1989
Neurotoxic action of lead: effect on tetrahydrobiopterin metabolism in the rat.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1985, Volume: 81, Issue:1

    Topics: Animals; Biopterins; Body Weight; Bone and Bones; Brain; Dihydropteridine Reductase; Lead; Lead Poisoning; Male; Neurotoxins; Pteridines; Rats; Rats, Inbred Strains; Tissue Distribution

1985
Stimulation of retinal dopamine biosynthesis in vivo by exogenous tetrahydrobiopterin: relationship to tyrosine hydroxylase activation.
    Brain research, 1985, Dec-16, Volume: 359, Issue:1-2

    Topics: Animals; Biopterins; Dark Adaptation; Dihydroxyphenylalanine; Dopamine; Enzyme Activation; Light; Male; Pteridines; Rats; Rats, Inbred Strains; Retina; Tyrosine 3-Monooxygenase

1985
Development of tetrahydrobiopterin and GTP cyclohydrolase in salivary glands of rats.
    The International journal of biochemistry, 1986, Volume: 18, Issue:2

    Topics: Aging; Aminohydrolases; Animals; Biopterins; GTP Cyclohydrolase; Kinetics; Male; Pteridines; Rats; Rats, Inbred Strains; Salivary Glands; Tyrosine 3-Monooxygenase

1986
Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells.
    Journal of neurochemistry, 1986, Volume: 46, Issue:4

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Medulla; Aminohydrolases; Animals; Biopterins; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cyclic AMP; GTP Cyclohydrolase; Pteridines; Pterins; Serotonin; Tyrosine; Tyrosine 3-Monooxygenase

1986
Tetrahydrobiopterin administration to rhesus macaques. Its appearance in CSF and effect on neurotransmitter synthesis.
    Neurochemical research, 1986, Volume: 11, Issue:2

    Topics: Animals; Biopterins; Blood-Brain Barrier; Dopamine; Injections, Intravenous; Macaca mulatta; Male; Neurotransmitter Agents; Norepinephrine; Pteridines; Serotonin; Time Factors

1986
Purification and properties of the phosphate eliminating enzyme involved in the biosynthesis of BH4 in man.
    Biochemical and biophysical research communications, 1985, Feb-28, Volume: 127, Issue:1

    Topics: Biopterins; Humans; Isoelectric Point; Liver; Magnesium; Molecular Weight; NADP; Neopterin; Pteridines; Pyrophosphatases; Temperature; Time Factors

1985
The C-6 proton of tetrahydrobiopterin is acquired from water, not NADPH, during de novo biosynthesis.
    The Journal of biological chemistry, 1985, May-10, Volume: 260, Issue:9

    Topics: Animals; Biopterins; Cattle; Deuterium; Gas Chromatography-Mass Spectrometry; Guanosine Triphosphate; Models, Chemical; NADP; Protons; Pteridines

1985
Atypical phenylketonuria with "dihydrobiopterin synthetase" deficiency: absence of phosphate-eliminating enzyme activity demonstrated in liver.
    European journal of pediatrics, 1985, Volume: 144, Issue:1

    Topics: Adult; Alcohol Oxidoreductases; Biopterins; Chemical Phenomena; Chemistry; Child; Child, Preschool; Female; Humans; Infant; Liver; Male; Neopterin; Phenylketonurias; Pteridines; Pyrophosphatases

1985
Regulation of tetrahydrobiopterin biosynthesis in cultured adrenal cortical tumor cells by adrenocorticotropin and adenosine 3',5'-cyclic monophosphate.
    Endocrinology, 1986, Volume: 118, Issue:5

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Animals; Biopterins; Bucladesine; Cell Line; Colforsin; Cosyntropin; Cyclic AMP; GTP Cyclohydrolase; Hydroxyprogesterones; Mice; Mutation; Progesterone; Pteridines

1986
A model for hyperphenylalaninaemia due to tetrahydrobiopterin deficiency.
    Journal of inherited metabolic disease, 1986, Volume: 9, Issue:1

    Topics: Animals; Biopterins; Brain; Catecholamines; Disease Models, Animal; Dose-Response Relationship, Drug; Hypoxanthines; Liver; Mice; Mice, Inbred BALB C; Phenylalanine; Pteridines

1986
In vivo measurement of dihydrofolate reductase and its inhibition by antifolates.
    Analytical biochemistry, 1988, Volume: 172, Issue:1

    Topics: Animals; Biopterins; Brain; Folic Acid Antagonists; Injections, Intraventricular; Liver; Male; Methotrexate; Mice; Pteridines; Pterins; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase

1988
Biosynthesis of biopterin. Studies on the mechanism of 6-pyruvoyltetrahydropteridine synthase.
    Biochemical and biophysical research communications, 1988, Feb-29, Volume: 151, Issue:1

    Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Neopterin; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Substrate Specificity

1988
On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin.
    Archives of biochemistry and biophysics, 1987, Volume: 255, Issue:2

    Topics: Alcohol Oxidoreductases; Animals; Antigen-Antibody Complex; Biopterins; Erythrocytes; Kinetics; Male; Molecular Weight; Pteridines; Pterins; Rats; Substrate Specificity; Tissue Distribution

1987
Inhibition of GTP cyclohydrolase I by pterins.
    Biochimica et biophysica acta, 1988, Apr-14, Volume: 965, Issue:1

    Topics: Aminohydrolases; Animals; Biopterins; Folic Acid; GTP Cyclohydrolase; Kinetics; Liver; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Rats; Xanthopterin

1988
Synthesis of enzymatically active D-7,8-dihydroneopterin-3'-triphosphate.
    Biochemical and biophysical research communications, 1988, May-16, Volume: 152, Issue:3

    Topics: Biopterins; Methods; Neopterin; Pteridines

1988
Inhibition of monocyte luminol-dependent chemiluminescence by tetrahydrobiopterin, and the free radical oxidation of tetrahydrobiopterin, dihydrobiopterin and dihydroneopterin.
    Cell biochemistry and function, 1988, Volume: 6, Issue:3

    Topics: Ascorbic Acid; Biopterins; Dithioerythritol; Free Radicals; Humans; Hydrogen Peroxide; In Vitro Techniques; Luminescent Measurements; Macrophages; Monocytes; Neopterin; Oxidation-Reduction; Pteridines

1988
Pteridines are produced during interleukin 2-induced T-cell proliferation and modulate transmission of this signal.
    Experimental cell research, 1986, Volume: 167, Issue:2

    Topics: Biopterins; Cell Cycle; Cell Division; Cells, Cultured; Humans; Interleukin-2; Pteridines; T-Lymphocytes

1986
Tetrahydrobiopterin in dystonia: identification of abnormal metabolism and therapeutic trials.
    Neurology, 1986, Volume: 36, Issue:6

    Topics: Adult; Aged; Biopterins; Dystonia; Female; Humans; Male; Middle Aged; Neopterin; Pteridines

1986
Rat striatal dopamine and tetrahydrobiopterin content following an intrastriatal injection of manganese chloride.
    Life sciences, 1986, Jun-09, Volume: 38, Issue:23

    Topics: Animals; Biopterins; Chlorides; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Manganese; Manganese Compounds; Pteridines; Rats; Rats, Inbred Strains; Time Factors

1986
Hypoxanthine and tetrahydrobiopterin treatment of a patient with features of the Lesch-Nyhan syndrome.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt A

    Topics: Adult; Allopurinol; Biopterins; Drug Administration Schedule; Humans; Hypoxanthine; Hypoxanthines; Lesch-Nyhan Syndrome; Male; Pteridines; Serotonin

1986
The effect of tetrahydrofolate on tetrahydrobiopterin metabolism.
    Journal of mental deficiency research, 1986, Volume: 30 ( Pt 2)

    Topics: Adult; Aged; Alzheimer Disease; Animals; Biopterins; Child, Preschool; Humans; In Vitro Techniques; Infant; Male; Middle Aged; Pteridines; Rats; Rats, Inbred Strains; Temporal Lobe; Tetrahydrofolates; Vitamin B 12

1986
[GTP cyclohydrolase activity in rat liver].
    Josai Shika Daigaku kiyo. The Bulletin of the Josai Dental University, 1985, Volume: 14, Issue:2-3

    Topics: Aminohydrolases; Animals; Biopterins; Carbon Radioisotopes; GTP Cyclohydrolase; Liver; Male; Pteridines; Pterins; Rats; Rats, Inbred Strains

1985
Neonatal hyperphenylalaninemia presumably caused by guanosine triphosphate-cyclohydrolase deficiency.
    The Journal of pediatrics, 1985, Volume: 106, Issue:6

    Topics: Aminohydrolases; Biopterins; GTP Cyclohydrolase; Humans; Infant, Newborn; Leukocyte Count; Liver; Male; Neopterin; Phenylalanine; Pteridines; Pterins; T-Lymphocytes

1985
Relationships between drug-induced changes in tetrahydrobiopterin and biogenic amine concentrations in rat brain.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:1

    Topics: Animals; Biogenic Amines; Biopterins; Brain Chemistry; Circadian Rhythm; Cocaine; Corticotropin-Releasing Hormone; Dextroamphetamine; Male; Methylphenidate; Pteridines; Rats; Rats, Inbred Strains; Tryptophan; Valine

1985
Malignant phenylketonuria due to defective synthesis of dihydrobiopterin.
    Israel journal of medical sciences, 1985, Volume: 21, Issue:6

    Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Drug Combinations; Female; Humans; Infant, Newborn; Levodopa; Male; Nervous System Diseases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine

1985
Modulation of interleukin 2 activity by lymphocyte-derived tetrahydrobiopterin.
    Die Naturwissenschaften, 1985, Volume: 72, Issue:6

    Topics: Animals; Biopterins; DNA; Humans; Interleukin-2; Lymphocytes; Mice; Pteridines; T-Lymphocytes

1985
The enzymatic activities of GTP cyclohydrolase, sepiapterin reductase, dihydropteridine reductase and dihydrofolate reductase; and tetrahydrobiopterin content in mammalian ocular tissues and in human senile cataracts.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1985, Volume: 80, Issue:1

    Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cataract; Cattle; Ciliary Body; Dihydropteridine Reductase; Eye; GTP Cyclohydrolase; Humans; Iris; Lens, Crystalline; Pteridines; Rabbits; Rats; Retina; Tetrahydrofolate Dehydrogenase

1985
Dyspropterin, an intermediate formed from dihydroneopterin triphosphate in the biosynthetic pathway of tetrahydrobiopterin.
    Biochimica et biophysica acta, 1985, Jun-18, Volume: 840, Issue:2

    Topics: Alcohol Oxidoreductases; Biopterins; Catalysis; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydropteridine Reductase; Hydroxylation; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Spectrophotometry, Ultraviolet

1985
Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved.
    European journal of biochemistry, 1985, May-02, Volume: 148, Issue:3

    Topics: Affinity Labels; Alcohol Oxidoreductases; Animals; Biopterins; Catalysis; Chromatography, High Pressure Liquid; Energy Transfer; Erythrocytes; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen Bonding; Kinetics; Liver; NADP; Oxidation-Reduction; Pteridines; Rats; Solvents; Stereoisomerism; Substrate Specificity; Tetrahydrofolate Dehydrogenase

1985
Hyperphenylalaninaemia caused by defects in biopterin metabolism.
    Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 1

    Topics: Amino Acid Metabolism, Inborn Errors; Animals; Biogenic Amines; Biopterins; Brain; Humans; Phenylalanine; Phenylketonurias; Pteridines

1985
Differential diagnosis of tetrahydrobiopterin deficiency.
    Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 1

    Topics: Amino Acid Metabolism, Inborn Errors; Biopterins; Diagnosis, Differential; GTP Cyclohydrolase; Humans; Phenylalanine; Phenylketonurias; Pteridines

1985
Clinical role of pteridine therapy in tetrahydrobiopterin deficiency.
    Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 1

    Topics: Amino Acid Metabolism, Inborn Errors; Biogenic Amines; Biopterins; Brain; Folic Acid; Folic Acid Deficiency; Humans; Infant; Phenylalanine; Phenylketonurias; Pteridines

1985
Biopterin, neopterin and tyrosine responses to combined oral phenylalanine and tetrahydrobiopterin loading tests in two normal children and in a girl with partial biopterin deficiency.
    Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 2

    Topics: Administration, Oral; Biopterins; Child; Female; Humans; Neopterin; Phenylalanine; Pteridines; Tyrosine

1985
Tetrahydrobiopterin in dihydropteridine reductase deficiency.
    The New England journal of medicine, 1986, Feb-20, Volume: 314, Issue:8

    Topics: Biopterins; Humans; NADH, NADPH Oxidoreductases; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines

1986
Synthesis, utilization, and structure of the tetrahydropterin intermediates in the bovine adrenal medullary de novo biosynthesis of tetrahydrobiopterin.
    The Journal of biological chemistry, 1986, Feb-25, Volume: 261, Issue:6

    Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chromatography, High Pressure Liquid; Kinetics; Pteridines; Serotonin; Spectrophotometry, Ultraviolet

1986
Tetrahydrobiopterin analogues: solution conformations of 6-methyltetrahydropterin, 7-methyltetrahydropterin, and cis- and trans-6,7-dimethyltetrahydropterins as determined by proton nuclear magnetic resonance.
    Biochemistry, 1985, Jan-15, Volume: 24, Issue:2

    Topics: Biopterins; Hydrogen-Ion Concentration; Isomerism; Magnetic Resonance Spectroscopy; Molecular Conformation; Pteridines; Solutions; Stereoisomerism; Structure-Activity Relationship

1985
6R-L-erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain.
    Archives of biochemistry and biophysics, 1985, May-15, Volume: 239, Issue:1

    Topics: Animals; Biopterins; Brain; Dopamine; Hydroxylation; Isomerism; Probenecid; Pteridines; Rats; Serotonin; Time Factors; Tryptophan; Tyrosine

1985
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates.
    Biochemical and biophysical research communications, 1985, May-16, Volume: 128, Issue:3

    Topics: Adrenal Medulla; Animals; Biopterins; Brain; Cattle; Chemical Phenomena; Chemistry; In Vitro Techniques; Kinetics; Liver; Neopterin; Pteridines; Pterins; Rats

1985
Phenylalanine hydroxylase: absolute configuration and source of oxygen of the 4a-hydroxytetrahydropterin species.
    Biochemistry, 1985, Jun-04, Volume: 24, Issue:12

    Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; Circular Dichroism; Gas Chromatography-Mass Spectrometry; Liver; Magnetic Resonance Spectroscopy; Optical Rotation; Phenylalanine Hydroxylase; Pteridines; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship

1985
Tetrahydrobiopterin metabolism in the Rett disease.
    Brain & development, 1985, Volume: 7, Issue:3

    Topics: Biopterins; Child; Dihydropteridine Reductase; Female; Humans; Intellectual Disability; NADH, NADPH Oxidoreductases; Neurocognitive Disorders; Pteridines; Stereotyped Behavior; Syndrome

1985
Tetrahydrobiopterin increases in adrenal medulla and cortex: a factor in the regulation of tyrosine hydroxylase.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:5

    Topics: Adrenal Cortex; Adrenal Glands; Adrenal Medulla; Animals; Biopterins; Catecholamines; Cycloheximide; Denervation; Hypophysectomy; Insulin; Kinetics; Male; Pteridines; Rats; Reserpine; Tyrosine 3-Monooxygenase

1981
Kinetic properties of tyrosine hydroxylase with natural tetrahydrobiopterin as cofactor.
    Biochimica et biophysica acta, 1981, Sep-15, Volume: 661, Issue:1

    Topics: Adrenal Medulla; Animals; Biopterins; Cattle; In Vitro Techniques; Kinetics; Pteridines; Stereoisomerism; Tyrosine 3-Monooxygenase

1981
Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis.
    Science (New York, N.Y.), 1981, Nov-20, Volume: 214, Issue:4523

    Topics: Aminohydrolases; Animals; Biopterins; Corpus Striatum; Dopamine; GTP Cyclohydrolase; Hydroxydopamines; Male; Pteridines; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine 3-Monooxygenase

1981
Short-term regulation of hydroxylase cofactor activity in rat brain.
    Journal of neurochemistry, 1981, Volume: 37, Issue:6

    Topics: Animals; Biopterins; Circadian Rhythm; Corpus Striatum; Dextroamphetamine; Kinetics; Locus Coeruleus; Male; Oxidoreductases; Physostigmine; Pteridines; Pterins; Quinones; Rats; Rats, Inbred Strains; Reserpine; Tyrosine 3-Monooxygenase

1981
Lead and tetrahydrobiopterin metabolism: possible effects on IQ.
    Lancet (London, England), 1982, Apr-24, Volume: 1, Issue:8278

    Topics: Adolescent; Adult; Aged; Biopterins; Child; Child, Preschool; Cognition; Female; Humans; Infant; Intelligence; Lead; Male; Middle Aged; Pteridines

1982
Tetrahydrobiopterin metabolism in chronic uraemia: possible explanation of dialysis encephalopathy.
    Lancet (London, England), 1982, Aug-28, Volume: 2, Issue:8296

    Topics: Biopterins; Brain Diseases; Chronic Disease; Humans; Pteridines; Renal Dialysis; Uremia

1982
Successful treatment of depression with tetrahydrobiopterin.
    Lancet (London, England), 1983, Mar-19, Volume: 1, Issue:8325

    Topics: Biogenic Amines; Biopterins; Depressive Disorder; Female; Humans; Middle Aged; Pteridines

1983
Hormonal regulation of guanosine triphosphate cyclohydrolase activity and biopterin levels in the rat adrenal cortex.
    Endocrinology, 1983, Volume: 112, Issue:6

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Biopterins; Cosyntropin; Cycloheximide; Guanylate Cyclase; Hypophysectomy; Insulin; Kinetics; Male; Pteridines; Rats; Rats, Inbred Strains; Reserpine; Tetrahydrofolate Dehydrogenase

1983
Tetrahydrobiopterin levels in cerebrospinal fluid of affectively ill patients.
    Lancet (London, England), 1983, Jul-02, Volume: 2, Issue:8340

    Topics: Adult; Aged; Biopterins; Depressive Disorder; Humans; Middle Aged; Pteridines

1983
Tetrahydropterin therapy for hyperphenylalaninemia caused by defective synthesis of tetrahydrobiopterin.
    Annals of neurology, 1983, Volume: 14, Issue:3

    Topics: Biopterins; Blood Glucose; Child; Dose-Response Relationship, Drug; Growth Hormone; Humans; Male; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Prolactin; Pteridines; Pterins

1983
Catecholamine-related enzymes and the biopterin cofactor in Parkinson's disease and related extrapyramidal diseases.
    Advances in neurology, 1984, Volume: 40

    Topics: Adult; Aged; Aromatic-L-Amino-Acid Decarboxylases; Basal Ganglia Diseases; Biopterins; Brain; Dopa Decarboxylase; Dopamine beta-Hydroxylase; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenylethanolamine N-Methyltransferase; Pteridines; Shy-Drager Syndrome; Tyrosine 3-Monooxygenase

1984
CSF tetrahydrobiopterin levels in patients with affective disorders.
    Lancet (London, England), 1984, Feb-04, Volume: 1, Issue:8371

    Topics: Biopterins; Chromatography, High Pressure Liquid; Humans; Mood Disorders; Pteridines

1984
A kinetic scattering approach to the non-linear instabilities of rat brain tyrosine hydroxylase preparations at several levels of tetrahydrobiopterin cofactor demonstrates evolutionary behavior characteristic of global dynamical systems.
    Brain research, 1984, May-14, Volume: 299, Issue:2

    Topics: Animals; Biological Evolution; Biopterins; Corpus Striatum; Kinetics; Male; Models, Chemical; Pteridines; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase

1984
Tetrahydrobiopterin metabolism in depression.
    Lancet (London, England), 1984, Jul-21, Volume: 2, Issue:8395

    Topics: Adult; Aged; Biopterins; Brain; Humans; Middle Aged; Mood Disorders; Pteridines

1984
Effect of dexamethasone on biopterin levels and tyrosine hydroxylase activity in PC-12 cells.
    Biochemical pharmacology, 1984, Aug-01, Volume: 33, Issue:15

    Topics: Adrenal Gland Neoplasms; Animals; Biopterins; Catecholamines; Cell Line; Dexamethasone; Pheochromocytoma; Pteridines; Rats; Tyrosine 3-Monooxygenase

1984
Biopterin synthesis defects: problems in diagnosis.
    Pediatrics, 1984, Volume: 74, Issue:6

    Topics: Biopterins; Diet; Female; Humans; Infant, Newborn; Metabolism, Inborn Errors; Neopterin; Neurotransmitter Agents; Phenylalanine; Pteridines

1984
Tetrahydrobiopterin metabolism in Down's syndrome and in non-Down's syndrome mental retardation.
    Journal of mental deficiency research, 1982, Volume: 26 (Pt 2)

    Topics: Adult; Aged; Biopterins; Down Syndrome; Female; Humans; Intellectual Disability; Male; Middle Aged; Phenylalanine; Pteridines

1982
[Development of the biosynthesis and excretion of pterins in phenylketonuria and its variants].
    Archives francaises de pediatrie, 1983, Volume: 40 Suppl 1

    Topics: Alcohol Oxidoreductases; Biopterins; Child; Chromatography, High Pressure Liquid; Humans; Phenylalanine; Phenylketonurias; Pteridines; Pterins

1983
[Biopterin synthesis defects: complete deficiencies (reductase and synthetase)].
    Archives francaises de pediatrie, 1983, Volume: 40 Suppl 1

    Topics: Alcohol Oxidoreductases; Biopsy, Needle; Biopterins; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Liver; Phenylalanine; Phenylketonurias; Pteridines; Pterins

1983
[Partial deficiency of tetrahydrobiopterin].
    Archives francaises de pediatrie, 1983, Volume: 40 Suppl 1

    Topics: Adolescent; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Female; Humans; Infant, Newborn; Male; Phenylalanine; Phenylketonurias; Pteridines; Pterins

1983
Tetrahydro-sepiapterin is an intermediate in tetrahydrobiopterin biosynthesis.
    Biochemical and biophysical research communications, 1983, Sep-30, Volume: 115, Issue:3

    Topics: Adrenal Medulla; Alcohol Oxidoreductases; Animals; Biopterins; Cattle; Escherichia coli; GTP Cyclohydrolase; Leuconostoc; Melatonin; Pteridines; Pterins; Serotonin; Tetrahydrofolate Dehydrogenase

1983
Tyrosine hydroxylase cofactor (tetrahydrobiopterin) in parkinsonism.
    Advances in neurology, 1984, Volume: 40

    Topics: Adult; Age Factors; Aged; Animals; Antiparkinson Agents; Biopterins; Brain Chemistry; Drug Evaluation, Preclinical; Haplorhini; Humans; Middle Aged; Parkinson Disease; Pteridines; Rats

1984
Intermediates in the enzymic synthesis of tetrahydrobiopterin in Drosophila melanogaster.
    Biochemical and biophysical research communications, 1984, May-16, Volume: 120, Issue:3

    Topics: Animals; Biopterins; Biotransformation; Catalysis; Drosophila melanogaster; Edetic Acid; Magnesium; NADP; Neopterin; Pteridines; Pterins

1984
Dihydropteridine reductase deficiency: non-response to oral tetrahydrobiopterin load test.
    Journal of inherited metabolic disease, 1984, Volume: 7, Issue:2

    Topics: Biopterins; Female; Fibroblasts; Humans; Infant; Lymphocytes; NADH, NADPH Oxidoreductases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine

1984
Combined tetrahydrobiopterin-phenylalanine loading test in the detection of partially defective biopterin synthesis.
    European journal of pediatrics, 1984, Volume: 142, Issue:2

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Biopterins; Child; Child, Preschool; Electroencephalography; Female; Humans; Neopterin; Phenylalanine; Pteridines

1984
The effect of ligands of phenylalanine 4-monooxygenase on the cAMP-dependent phosphorylation of the enzyme.
    The Journal of biological chemistry, 1984, Sep-25, Volume: 259, Issue:18

    Topics: Adenosine Diphosphate; Animals; Biopterins; Kinetics; Magnesium; Phenylalanine; Phenylalanine Hydroxylase; Phosphorylation; Protein Kinases; Pteridines; Rats; Time Factors

1984
Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:6

    Topics: Adrenal Medulla; Animals; Biopterins; Brain; Cattle; Cells, Cultured; Cricetinae; Guanosine Triphosphate; Methotrexate; Mice; Pteridines; Pterins; Rats

1983
Urinary excretion of biopterin and neopterin in psychiatric disorders.
    Psychiatry research, 1984, Volume: 11, Issue:2

    Topics: Adult; Biopterins; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Neopterin; Pteridines; Schizophrenia

1984
Peroxidase catalysed aerobic degradation of 5,6,7,8-tetrahydrobiopterin at physiological pH.
    European journal of biochemistry, 1983, Oct-03, Volume: 135, Issue:3

    Topics: Aerobiosis; Biopterins; Catalysis; Chemical Phenomena; Chemistry; Dihydropteridine Reductase; Horseradish Peroxidase; Humans; Hydrogen-Ion Concentration; Liver; Oxidation-Reduction; Peroxidases; Pteridines; Spectrophotometry, Ultraviolet; Stereoisomerism

1983
Tetrahydrobiopterin is synthesized by separate pathways from dihydroneopterin triphosphate and from sepiapterin in adrenal medulla preparations.
    Archives of biochemistry and biophysics, 1983, Volume: 227, Issue:1

    Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chemical Phenomena; Chemistry; Guanosine Triphosphate; Methotrexate; Neopterin; Pteridines; Pterins

1983
Intestinal absorption of tetrahydrobiopterin and biopterin in man.
    Biochemical medicine, 1983, Volume: 30, Issue:3

    Topics: Ascorbic Acid; Biopterins; Ethanol; Humans; Intestinal Absorption; Pteridines

1983
[Hyperphenylalaninemia on account of biopterin deficiency. The phenylalanine hydroxylase complex and presentation of a patient with cofactor deficiency].
    Ugeskrift for laeger, 1983, Nov-28, Volume: 145, Issue:48

    Topics: Biopterins; Humans; Infant; Male; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines

1983
Study of tetrahydrobiopterin and 6-methyltetrahydropterin on alcohol dependence in mice.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 42, Issue:1

    Topics: Alcoholism; Animals; Biopterins; Ethanol; Female; Humans; Mice; Pteridines; Pterins; Substance Withdrawal Syndrome

1983
Tetrahydrobiopterin and total biopterin content of neuroblastoma (N1E-115, N2A) and pheochromocytoma (PC-12) clones and the dependence of catecholamine synthesis on tetrahydrobiopterin concentration in PC-12 cells.
    Journal of neurochemistry, 1984, Volume: 42, Issue:2

    Topics: Adrenal Gland Neoplasms; Animals; Biopterins; Catecholamines; Cell Line; Chromatography, High Pressure Liquid; Kinetics; Mice; Neuroblastoma; Pheochromocytoma; Pteridines; Rats

1984
Therapeutic efficacy of tetrahydrobiopterin in Parkinson's disease.
    Advances in neurology, 1984, Volume: 40

    Topics: Aged; Antidepressive Agents; Antiparkinson Agents; Biopterins; Brain; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Middle Aged; Parkinson Disease; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines

1984
Blood spots on Guthrie cards can be used for inherited tetrahydrobiopterin deficiency screening in hyperphenylalaninaemic infants.
    Archives of disease in childhood, 1984, Volume: 59, Issue:1

    Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Dihydropteridine Reductase; Humans; Infant, Newborn; Methods; Phenylalanine; Phenylketonurias; Pteridines; Specimen Handling

1984
Ligand effects on the phosphorylation state of hepatic phenylalanine hydroxylase.
    The Journal of biological chemistry, 1984, Feb-25, Volume: 259, Issue:4

    Topics: Animals; Biopterins; Enzyme Activation; Kinetics; Ligands; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Phosphorylation; Protein Kinases; Pteridines; Rats; Rats, Inbred Strains

1984
Current status of biopterin screening.
    The Journal of pediatrics, 1984, Volume: 104, Issue:4

    Topics: Biopterins; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Mass Screening; Neopterin; Phenylalanine; Phenylketonurias; Pteridines

1984
An abbreviated synthesis of tetrahydropteridines.
    Analytical biochemistry, 1984, Volume: 137, Issue:2

    Topics: Biopterins; Chemical Phenomena; Chemistry; Isomerism; Pteridines; Pterins; Temperature

1984
Two new tetrahydropterin intermediates in the adrenal medullary de novo biosynthesis of tetrahydrobiopterin.
    Biochemical and biophysical research communications, 1984, May-16, Volume: 120, Issue:3

    Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chromatography, High Pressure Liquid; Electrochemistry; Kinetics; NADP; Oxidation-Reduction; Pteridines; Pterins

1984
GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia.
    European journal of pediatrics, 1984, Volume: 141, Issue:4

    Topics: Adolescent; Aminohydrolases; Biopterins; Child; Child, Preschool; Dopamine; Female; GTP Cyclohydrolase; Humans; Infant; Liver; Metabolism, Inborn Errors; Muscle Hypotonia; Neopterin; Phenylalanine; Pteridines; Serotonin

1984
Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type.
    Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:7

    Topics: Aged; Alzheimer Disease; Biopterins; Dihydropteridine Reductase; Humans; Kinetics; Neopterin; Pteridines; Temporal Lobe

1984
A case of tetrahydrobiopterin deficiency due to a defective synthesis of dihydrobiopterin.
    Journal of inherited metabolic disease, 1982, Volume: 5, Issue:2

    Topics: Biopterins; Humans; Infant; Male; Phenylalanine; Pteridines

1982
The development of tetrahydrobiopterin and guanosine-5'-triphosphate cyclohydrolase: differential patterns in rat brain and pineal gland.
    Brain research, 1983, Jan-10, Volume: 258, Issue:2

    Topics: Aging; Aminohydrolases; Animals; Biopterins; Brain; Female; GTP Cyclohydrolase; Male; Organ Specificity; Pineal Gland; Pteridines; Rats; Rats, Inbred Strains; Sex Factors

1983
Treatment of dystonia with tetrahydrobiopterin.
    The New England journal of medicine, 1983, Jan-20, Volume: 308, Issue:3

    Topics: Adult; Aged; Biopterins; Dystonia; Humans; Middle Aged; Pteridines

1983
Biosynthesis of tetrahydrobiopterin in the presence of dihydrofolate reductase inhibitors.
    Molecular pharmacology, 1983, Volume: 24, Issue:1

    Topics: Animals; Biopterins; Cell Line; Clone Cells; Folic Acid Antagonists; GTP Cyclohydrolase; Guanosine Triphosphate; Male; Methotrexate; Neuroblastoma; Pteridines; Rats; Rats, Inbred Strains

1983
Tetrahydrobiopterin metabolism in senile dementia of Alzheimer type.
    Journal of neurology, neurosurgery, and psychiatry, 1983, Volume: 46, Issue:6

    Topics: Aged; Alzheimer Disease; Biopterins; Chromatography, High Pressure Liquid; Dementia; Humans; Middle Aged; Pteridines

1983
Regulation of pterin synthesis.
    Archives francaises de pediatrie, 1983, Volume: 40 Suppl 1

    Topics: Biopterins; Dihydropteridine Reductase; Dopamine; Guanosine Triphosphate; Humans; Phenylpyruvic Acids; Pteridines

1983
Unconjugated pteridines in human milk.
    Clinica chimica acta; international journal of clinical chemistry, 1982, May-06, Volume: 121, Issue:1

    Topics: Animals; Biopterins; Drug Stability; Female; Humans; Milk; Pteridines

1982
Cerebrospinal fluid hydroxylase cofactor in schizophrenia.
    Psychiatry research, 1982, Volume: 6, Issue:2

    Topics: Adult; Biopterins; Blood Platelets; Female; Humans; Male; Monoamine Oxidase; Pteridines; Schizophrenia; Schizophrenic Psychology

1982
[Phenylalanine hydroxylating activity in Tawa sarcoma].
    Josai Shika Daigaku kiyo. The Bulletin of the Josai Dental University, 1981, Volume: 10, Issue:1

    Topics: Animals; Biopterins; Hydroxylation; Liver Neoplasms; Neoplasms, Experimental; Phenylalanine Hydroxylase; Pteridines; Rats; Rats, Inbred Strains; Sarcoma

1981
Determination of reduced biopterins by high pressure liquid chromatography and subsequent electrochemical detection.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1982, Volume: 363, Issue:3

    Topics: Biopterins; Chromatography, High Pressure Liquid; Electrochemistry; Electrodes; Indicators and Reagents; Pteridines; Spectrophotometry, Ultraviolet

1982
Atypical phenylketonuria with defective biopterin metabolism. Monotherapy with tetrahydrobiopterin or sepiapterin, screening and study of biosynthesis in man.
    European journal of pediatrics, 1982, Volume: 138, Issue:2

    Topics: Biopterins; Child, Preschool; Female; Humans; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins; Serotonin

1982
Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin: evidence that peripherally administered tetrahydropterins enter the brain.
    Pediatrics, 1982, Volume: 70, Issue:3

    Topics: Biopterins; Brain; Child; Child, Preschool; Female; Humans; Male; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins

1982
Determination of L-erythro-tetrahydrobiopterin in biological tissues by high pressure liquid chromatography and electrochemical detection.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1982, Volume: 363, Issue:10

    Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; Corpus Striatum; Electrochemistry; Medulla Oblongata; Pteridines; Rats

1982
Phenylketonuria with a progressive neurological disorder not responsive to tetrahydrobiopterin.
    Acta paediatrica Scandinavica, 1982, Volume: 71, Issue:5

    Topics: Biopterins; Female; Humans; Infant; Nerve Degeneration; Phenylketonurias; Pteridines

1982
Aging and CSF hydroxylase cofactor.
    Neurology, 1980, Volume: 30, Issue:11

    Topics: Adult; Aged; Aging; Biopterins; Humans; Middle Aged; Parkinson Disease; Pteridines

1980
Peripherally administered reduced pterins do enter the brain.
    Science (New York, N.Y.), 1981, May-22, Volume: 212, Issue:4497

    Topics: Animals; Biopterins; Blood-Brain Barrier; Brain; Male; Pteridines; Pterins; Rats; Stereoisomerism; Structure-Activity Relationship

1981
[Hyperphenylalaninemia in 1981. A diagnostic approach (author's transl)].
    Archives francaises de pediatrie, 1981, Volume: 38, Issue:8

    Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Clinical Enzyme Tests; Diagnosis, Differential; Dihydropteridine Reductase; Humans; Infant; Infant, Newborn; Liver; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines

1981
Effects of structures of tetrahydropterin cofactors on rat brain tryptophan hydroxylase.
    Biochimica et biophysica acta, 1980, Feb-14, Volume: 611, Issue:2

    Topics: Animals; Biopterins; Brain; Kinetics; Pteridines; Rats; Structure-Activity Relationship; Tryptophan Hydroxylase

1980
Lithium and chlorimipramine differentially alter bilateral asymmetry in mesostriatal serotonin metabolites and kinetic conformations of midbrain tryptophan hydroxylase with respect to tetrahydrobiopterin cofactor.
    Neuropharmacology, 1980, Volume: 19, Issue:1

    Topics: Animals; Biopterins; Clomipramine; Corpus Striatum; Kinetics; Lithium; Male; Mesencephalon; Protein Conformation; Pteridines; Rats; Serotonin; Tryptophan Hydroxylase

1980
Early diagnosis of hyperphenylalaninemia due to tetrahydrobiopterin deficiency (malignant hyperphenylalaninemia).
    The Journal of pediatrics, 1980, Volume: 96, Issue:5

    Topics: Biopterins; Humans; Infant, Newborn; Phenylalanine; Phenylketonurias; Pteridines

1980
Studies on biologically active pteridines. III. The absolute configuration at the C-6 chiral center of tetrahydrobiopterin cofactor and related compounds.
    Journal of biochemistry, 1980, Volume: 87, Issue:3

    Topics: Biopterins; Circular Dichroism; Molecular Conformation; Pteridines; Stereoisomerism

1980
The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.
    The Journal of biological chemistry, 1994, May-13, Volume: 269, Issue:19

    Topics: Allosteric Regulation; Amino Acid Oxidoreductases; Animals; Biopterins; Brain; Indazoles; Kinetics; Nitric Oxide Synthase; Pteridines; Substrate Specificity; Swine

1994
Dopamine-releasing action of 6R-L-erythro-tetrahydrobiopterin: analysis of its action site using sepiapterin.
    Journal of neurochemistry, 1994, Volume: 63, Issue:2

    Topics: alpha-Methyltyrosine; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Biopterins; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Isomerism; Kinetics; Male; Methyltyrosines; Microdialysis; Nitric Oxide Synthase; Pteridines; Pterins; Rats; Rats, Wistar; Time Factors; Tyrosine 3-Monooxygenase

1994
Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells.
    Kidney international, 1994, Volume: 46, Issue:5

    Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Cells, Cultured; Dose-Response Relationship, Drug; Glomerular Mesangium; GTP Cyclohydrolase; Guanosine Triphosphate; Hypoxanthines; Interleukin-1; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Rats; Recombinant Proteins

1994
Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages.
    Blood, 1995, Aug-01, Volume: 86, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Base Sequence; Biopterins; Cell Line; DNA Primers; Enzyme Induction; Gene Expression; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Molecular Sequence Data; Monocytes; Nitrates; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; RNA, Messenger

1995
Atomic structure of GTP cyclohydrolase I.
    Structure (London, England : 1993), 1995, May-15, Volume: 3, Issue:5

    Topics: Alcohol Oxidoreductases; Bacterial Proteins; Binding Sites; Biopterins; Catalysis; Crystallography, X-Ray; Escherichia coli; GTP Cyclohydrolase; Guanosine Triphosphate; Models, Molecular; Neopterin; Phosphorus-Oxygen Lyases; Protein Conformation; Pteridines

1995
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.
    The Journal of biological chemistry, 1993, Jan-25, Volume: 268, Issue:3

    Topics: Amino Acid Oxidoreductases; Biopterins; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypoxanthines; Interferon-gamma; Lipopolysaccharides; Neopterin; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Tumor Necrosis Factor-alpha; Umbilical Veins

1993
The effect of tetrahydrobiopterin on the in situ phosphorylation of tyrosine hydroxylase in rat striatal synaptosomes.
    Neurochemical research, 1994, Volume: 19, Issue:5

    Topics: Animals; Biopterins; Bucladesine; Corpus Striatum; Ethers, Cyclic; Male; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Protein Phosphatase 2; Pteridines; Pterins; Rats; Rats, Sprague-Dawley; Synaptosomes; Tyrosine 3-Monooxygenase

1994
6R-L-erythro-5,6,7,8-tetrahydrobiopterin: a regulator of neurotransmitter release.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Hippocampus; Infusions, Parenteral; Kinetics; Male; Methyltyrosines; Microdialysis; Pteridines; Pterins; Rats; Rats, Wistar; Reserpine; Stereoisomerism

1993
Effect of pteridine derivatives on intracellular calcium concentration in human monocytic cells.
    FEBS letters, 1993, Mar-08, Volume: 318, Issue:3

    Topics: Biopterins; Calcium; Cell Line; Egtazic Acid; Humans; Lanthanum; Monocytes; Neopterin; Pteridines

1993
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Dec-05, Volume: 92, Issue:25

    Topics: 3T3 Cells; Animals; Biopterins; Blotting, Northern; Blotting, Western; Cytosol; Dose-Response Relationship, Drug; Enzyme Induction; Genetic Engineering; Genetic Vectors; Humans; Mice; Nitric Oxide Synthase; Nitrites; Protein Conformation; Pteridines; Pterins; Recombinant Proteins; Retroviridae

1995
Effects of depletion of intracellular tetrahydrobiopterin in murine erythroleukemia cells.
    Experimental cell research, 1996, Jan-10, Volume: 222, Issue:1

    Topics: Acetamides; Alcohol Oxidoreductases; Animals; Biopterins; Cell Differentiation; Cell Division; Enzyme Inhibitors; Friend murine leukemia virus; G1 Phase; GTP Cyclohydrolase; Hemoglobins; Hypoxanthines; Leukemia, Erythroblastic, Acute; Mice; Phosphorylation; Pteridines; Retinoblastoma Protein; Tumor Cells, Cultured

1996
Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells.
    The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24

    Topics: Arginine; Biopterins; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Sugar Acids; Transcription, Genetic; Tumor Necrosis Factor-alpha

1996
Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries.
    Circulation research, 1996, Volume: 79, Issue:2

    Topics: Animals; Anions; Biopterins; Calcium; Cerebral Arteries; Culture Media; Cyclic GMP; Dogs; Endothelium, Vascular; In Vitro Techniques; Pteridines; Pterins; Superoxides; Vasodilation

1996
Tetrahydrobiopterin loading test in xanthine dehydrogenase and molybdenum cofactor deficiencies.
    Biochemical and molecular medicine, 1996, Volume: 58, Issue:2

    Topics: Administration, Oral; Adult; Antioxidants; Biopterins; Child, Preschool; Coenzymes; Female; Heterozygote; Humans; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Metalloproteins; Middle Aged; Molybdenum Cofactors; Pregnancy; Pteridines; Pterins; Xanthine Dehydrogenase; Xanthopterin

1996
Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin.
    Circulation, 1996, Sep-15, Volume: 94, Issue:6

    Topics: Animals; Biopterins; Endothelium, Vascular; Enzyme Inhibitors; Hemodynamics; Hypoxanthines; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Pteridines; Pterins; Reference Values; Swine; Vasodilation

1996
Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites.
    Biochemistry, 1996, Dec-24, Volume: 35, Issue:51

    Topics: Animals; Binding Sites; Biopterins; Dimerization; Heme; In Vitro Techniques; Kinetics; Molecular Structure; Neurons; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Pteridines; Rats; Recombinant Proteins; Spectrophotometry

1996
Effects of activating and deactivating cytokines on the functionally linked tetrahydrobiopterin. No pathways in vascular smooth muscle cells.
    Immunology letters, 1996, Dec-01, Volume: 54, Issue:1

    Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cytokines; Humans; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-4; Lipopolysaccharides; Muscle, Smooth, Vascular; Nitric Oxide; Pteridines; Pterins; Rats; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

1996
Modulation of adenovirus-mediated gene transfer by nitric oxide.
    American journal of respiratory cell and molecular biology, 1997, Volume: 16, Issue:5

    Topics: 3T3 Cells; Adenoviruses, Human; Animals; Antioxidants; beta-Galactosidase; Biopterins; Cell Survival; Cyclic GMP; Enzyme Inhibitors; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Humans; Luciferases; Lung; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Pteridines; Pterins; Transfection

1997
Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin.
    Biochemistry, 1997, Jul-08, Volume: 36, Issue:27

    Topics: Animals; Biopterins; Dimerization; Electrophoresis, Polyacrylamide Gel; Heme; Kinetics; Macrophages; Mice; Nitric Oxide Synthase; Pteridines; Recombinant Proteins; Spectrophotometry

1997
Pteridines in the control of pigmentation.
    The Journal of investigative dermatology, 1997, Volume: 109, Issue:1

    Topics: Adult; Biopterins; Exudates and Transudates; Female; GTP Cyclohydrolase; Humans; Male; Phenylalanine Hydroxylase; Pigmentation Disorders; Pteridines; Skin Diseases, Vesiculobullous; Time Factors; Tumor Necrosis Factor-alpha; Ultraviolet Rays

1997
Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content.
    Life sciences, 1997, Volume: 61, Issue:7

    Topics: Animals; Biopterins; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Hypoxanthines; Nitric Oxide Synthase; Oxidative Stress; Pteridines; Pterins; Superoxides

1997
Tetrahydrobiopterin modulates cyclooxygenase-2 expression in human mesangial cells.
    Biochemical and biophysical research communications, 1997, Dec-08, Volume: 241, Issue:1

    Topics: Biopterins; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Methotrexate; NG-Nitroarginine Methyl Ester; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Pteridines; Pterins; Quinoxalines; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha

1997
Expression and function of recombinant endothelial NO synthase in coronary artery smooth muscle cells.
    Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:11

    Topics: Adenoviridae; Animals; Biopterins; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Cyclic GMP; DNA Replication; Enzyme Induction; Genes, Reporter; Genetic Vectors; GTP Cyclohydrolase; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pteridines; Pterins; Recombinant Fusion Proteins; Superoxide Dismutase; Swine; Transfection

1997
Modulation of inducible nitric oxide synthase mRNA stability by tetrahydrobiopterin in vascular smooth muscle cells.
    Biochemical and biophysical research communications, 1998, Feb-04, Volume: 243, Issue:1

    Topics: Animals; Base Sequence; Biopterins; Cells, Cultured; Dicumarol; DNA Primers; Drug Stability; Gene Expression Regulation, Enzymologic; Kinetics; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Pteridines; Pterins; Rats; RNA, Messenger

1998
Coexpression of GTP cyclohydrolase I and inducible nitric oxide synthase mRNAs in mouse osteoblastic cells activated by proinflammatory cytokines.
    FEBS letters, 1998, May-29, Volume: 428, Issue:3

    Topics: 3T3 Cells; Animals; Apoptosis; Biopterins; Cell Nucleus; Cell Survival; Curcumin; Cytokines; DNA Fragmentation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Hypoxanthines; Interferon-gamma; Interleukin-1; Kinetics; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoblasts; Penicillamine; Proline; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Thiocarbamates; Transcription Factor AP-1; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha

1998
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.
    Pharmacology & toxicology, 1998, Volume: 82, Issue:6

    Topics: Animals; Arginine; Biopterins; Cattle; Cells, Cultured; Endothelium, Vascular; Hydrogen Peroxide; Ionomycin; omega-N-Methylarginine; Pteridines; Pterins; Rats; Serotonin

1998
Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death.
    Life sciences, 1998, Volume: 63, Issue:18

    Topics: Animals; Aorta, Thoracic; Biopterins; Cattle; Cell Death; Cytokines; Endothelium, Vascular; Enzyme Induction; L-Lactate Dehydrogenase; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penicillamine; Pteridines; Pterins; S-Nitroso-N-Acetylpenicillamine; Serotonin

1998
SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin.
    Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:2

    Topics: Animals; Antioxidants; Aorta; Benzoates; Biopterins; Catalase; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Iron Chelating Agents; L-Lactate Dehydrogenase; Molsidomine; Nitric Oxide; Plant Extracts; Pteridines; Pterins; Reactive Oxygen Species; Superoxide Dismutase; Trypan Blue

1999
Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase.
    The Journal of biological chemistry, 1999, Aug-27, Volume: 274, Issue:35

    Topics: Arginine; Biopterins; Dimerization; Enzyme Stability; Escherichia coli; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Conformation; Pteridines; Recombinant Proteins; Spectrophotometry; Spermine

1999
Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function.
    Biochemical and biophysical research communications, 1999, Oct-05, Volume: 263, Issue:3

    Topics: Antioxidants; Biopterins; Endothelium, Vascular; Kinetics; Nitrates; Nitric Oxide Synthase; Oxidants; Oxidation-Reduction; Pteridines

1999
Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: structure-activity relationship of antagonists of (6R)-5,6,7,8-tetrahydrobiopterin cofactor.
    Journal of medicinal chemistry, 1999, Oct-07, Volume: 42, Issue:20

    Topics: Animals; Biopterins; Enzyme Inhibitors; Isoenzymes; Neurons; Nitric Oxide Synthase; Pteridines; Structure-Activity Relationship; Swine

1999
Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats: protective effect of tetrahydrobiopterin.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:1

    Topics: Animals; Antioxidants; Biopterins; Male; Nitric Oxide; Pteridines; Pterins; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Stomach

2000
Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin.
    The Journal of biological chemistry, 2000, Jun-09, Volume: 275, Issue:23

    Topics: Animals; Aorta; Arginine; Ascorbic Acid; Atrial Natriuretic Factor; Biopterins; Calcimycin; Cattle; Cell Line; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Pteridines; Pterins; Recombinant Proteins; Spodoptera; Swine; Transfection

2000
Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin.
    Journal of neurochemistry, 2000, Volume: 74, Issue:6

    Topics: Animals; Antioxidants; Biopterins; Buthionine Sulfoximine; Cell Survival; Dopamine; Enzyme Inhibitors; Female; Glutathione; Glutathione Peroxidase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Parkinson Disease; Pregnancy; Pteridines; Pterins; Pyrazoles; Rats; Rats, Sprague-Dawley; tert-Butylhydroperoxide

2000
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.
    The Biochemical journal, 2000, Jul-01, Volume: 349, Issue:Pt 1

    Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Chromatography, High Pressure Liquid; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Immunoblotting; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Isoforms; Pteridines; Pterins; Rats; Rats, Mutant Strains

2000
Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging.
    Brain & development, 2000, Volume: 22 Suppl 1

    Topics: Aging; Animals; Animals, Newborn; Biopterins; Body Weight; Brain; Growth; Kidney; Liver; Mice; Mice, Inbred ICR; Organ Size; Pteridines

2000
L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin.
    The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1

    Topics: Ascorbic Acid; Biopterins; Cells, Cultured; Citrulline; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; GTP Cyclohydrolase; Humans; Hypoxanthines; Nitric Oxide; Nitric Oxide Synthase; Phosphorus-Oxygen Lyases; Pteridines; Pterins; RNA, Messenger; Solutions; Umbilical Cord

2001
Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis.
    Circulation, 2000, Oct-31, Volume: 102, Issue:18

    Topics: Acetylcholine; Animals; Arteriosclerosis; Atrial Appendage; Biopterins; Cholesterol; Coronary Vessels; Diet, Atherogenic; Dose-Response Relationship, Drug; Endothelium, Vascular; Histamine; Humans; In Vitro Techniques; Nitroprusside; Pteridines; Pterins; Serotonin; Substance P; Swine, Miniature; Vascular Resistance; Vasoconstriction; Vasodilation; Vasodilator Agents

2000
Inhibition of endotoxin-induced vascular hyporeactivity by 4-amino-tetrahydrobiopterin.
    British journal of pharmacology, 2000, Volume: 131, Issue:8

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Biopterins; Bradykinin; Calcimycin; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Endotoxins; Enzyme Inhibitors; Hydrazines; In Vitro Techniques; Lipopolysaccharides; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Nitrogen Oxides; Norepinephrine; Pteridines; Pterins; Pulmonary Artery; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

2000
Paracrine neuroprotective effect of nitric oxide in the developing retina.
    Journal of neurochemistry, 2001, Volume: 76, Issue:4

    Topics: Animals; Animals, Newborn; Anisomycin; Arginine; Biopterins; Cell Death; Cells, Cultured; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; NADPH Dehydrogenase; Neuroprotective Agents; Nitric Oxide; Paracrine Communication; Penicillamine; Pteridines; Pterins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine

2001
The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species.
    Free radical biology & medicine, 2001, Mar-01, Volume: 30, Issue:5

    Topics: Antioxidants; Biopterins; Catalase; Cell Division; Cell Line; Cell Survival; Endothelium, Vascular; Free Radical Scavengers; Humans; In Vitro Techniques; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Pulmonary Artery; Reactive Oxygen Species; Superoxide Dismutase; Vehicle Emissions

2001
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.
    Circulation, 2001, Mar-06, Volume: 103, Issue:9

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Apolipoproteins E; Biopterins; Calcimycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Ionophores; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroglycerin; Pteridines; Pterins; Superoxides; Vasodilation; Vasodilator Agents

2001
Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase.
    Nitric oxide : biology and chemistry, 2001, Volume: 5, Issue:2

    Topics: Antioxidants; Biopterins; Catalysis; Electric Conductivity; Electrochemistry; Nitric Oxide Synthase; Oxidation-Reduction; Pteridines

2001
Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6

    Topics: Animals; Arginine; Biopterins; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Vessels; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Humans; Hypercholesterolemia; In Vitro Techniques; Infusions, Intra-Arterial; Ionophores; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pteridines; Pterins; Reactive Oxygen Species; Species Specificity; Substance P; Swine; Vasoconstrictor Agents; Vasodilator Agents

2001
Glucocorticoids inhibit tetrahydrobiopterin-dependent endothelial function.
    Experimental biology and medicine (Maywood, N.J.), 2001, Volume: 226, Issue:1

    Topics: Animals; Aorta, Thoracic; Biopterins; Dexamethasone; Endothelium, Vascular; Glucocorticoids; GTP Cyclohydrolase; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Phenylephrine; Pteridines; Pterins; Rats; Rats, Wistar; Vasoconstriction

2001
Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:6

    Topics: Acetylcholine; Animals; Aorta; Binding Sites; Biopterins; Cattle; Endothelium, Vascular; Fluorescent Dyes; Free Radicals; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pteridines; Pterins; Reactive Oxygen Species; Rhodamines; Superoxides; Tetrahydrofolates; Vasodilation

2002
Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biopterins; Cell Movement; Graft Rejection; Kidney; Kidney Transplantation; Kinetics; Macrophages; Models, Biological; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pteridines; Pterins; Rats; Rats, Inbred Lew; Superoxides

2002
Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin.
    Brain research, 2002, May-10, Volume: 935, Issue:1-2

    Topics: Animals; Animals, Newborn; Biopterins; Buthionine Sulfoximine; Coculture Techniques; Dopamine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutathione; Homovanillic Acid; Hypoxanthines; Neostriatum; Organ Culture Techniques; Oxidative Stress; Parkinson Disease; Pteridines; Pterins; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase

2002
Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin.
    Cytokine, 2002, Apr-21, Volume: 18, Issue:2

    Topics: Animals; Biopterins; Cell Fusion; Glucose; Hypoxanthines; Insulin; Insulin Secretion; Insulinoma; Interleukin-1; Islets of Langerhans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Pancreatic Neoplasms; Pteridines; Pterins; Rats; Tumor Cells, Cultured

2002
Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major.
    The Journal of biological chemistry, 2002, Oct-11, Volume: 277, Issue:41

    Topics: Amino Acid Sequence; Animals; Biopterins; Humans; Leishmania major; Molecular Sequence Data; Open Reading Frames; Oxidoreductases; Protozoan Proteins; Pteridines; Recombinant Proteins; Sequence Alignment; Trypanosoma brucei brucei

2002
Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Oct-01, Volume: 22, Issue:10

    Topics: Acetylcholine; Acetylcysteine; Animals; Antioxidants; Aorta, Thoracic; Arteriosclerosis; Biopterins; Calcimycin; Cholesterol; Diet; Endothelium, Vascular; Free Radical Scavengers; Hyperlipidemias; Ionophores; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Pteridines; Pterins; Rabbits; Sulfhydryl Compounds; Vasodilator Agents

2002
Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Nov-01, Volume: 22, Issue:21

    Topics: Acetylcholine; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biopterins; Blotting, Western; Catecholamines; Cells, Cultured; Ciliary Neurotrophic Factor; Dopamine; Foot; Mice; Neurons; Neurotransmitter Agents; Norepinephrine; Phenotype; Pteridines; Pterins; Skin; Sweat Glands; Sympathetic Fibers, Postganglionic; Tissue Extracts; Tyrosine 3-Monooxygenase

2002
Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:1

    Topics: Acetylcholine; Animals; Aorta; Biopterins; Culture Techniques; Dithiothreitol; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Nitric Oxide Synthase; Nitroarginine; Pteridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Reducing Agents; Vasoconstriction; Vasodilation

2003
Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures.
    Journal of neurochemistry, 2003, Volume: 85, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Biopterins; Cell Count; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Dopamine; Dose-Response Relationship, Drug; Electron Transport Complex I; Hypoxanthines; In Vitro Techniques; L-Lactate Dehydrogenase; NADH, NADPH Oxidoreductases; Neurons; Neuroprotective Agents; Nomifensine; Propidium; Pteridines; Pterins; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase

2003
Regulation of tyrosinase by tetrahydropteridines and H2O2.
    Biochemical and biophysical research communications, 2004, Dec-24, Volume: 325, Issue:4

    Topics: Binding Sites; Biopterins; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Monophenol Monooxygenase; Oxidation-Reduction; Protein Binding; Pteridines; Tyrosine

2004
Regulation of tyrosinase by tetrahydropteridines--what is real? A comment on the work published by Wood et al. on December 24, 2004.
    Biochemical and biophysical research communications, 2005, Apr-15, Volume: 329, Issue:3

    Topics: Animals; Binding Sites; Biopterins; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Monophenol Monooxygenase; Oxidation-Reduction; Protein Binding; Pteridines; Tyrosine

2005
Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
    Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15

    Topics: Animals; Binding Sites; Biopterins; Crystallography, X-Ray; Humans; Isoenzymes; Ligands; Models, Molecular; Molecular Structure; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Structure, Tertiary; Pteridines; Rats; Structure-Activity Relationship

2005
Pigment pattern formation in the quail mutant of the silkworm, Bombyx mori: parallel increase of pteridine biosynthesis and pigmentation of melanin and ommochromes.
    Pigment cell research, 2006, Volume: 19, Issue:4

    Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Base Sequence; Biopterins; Bombyx; Cytoplasmic Granules; GTP Cyclohydrolase; Integumentary System; Larva; Melanins; Microfilament Proteins; Molecular Sequence Data; Mutant Proteins; Phenothiazines; Pigmentation; Pigments, Biological; Pteridines; RNA, Messenger

2006
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.
    Current genetics, 2009, Volume: 55, Issue:3

    Topics: Animals; Biopterins; Drug Resistance; Folic Acid; Hydrogen Peroxide; Leishmania major; Methylnitronitrosoguanidine; Molsidomine; Multienzyme Complexes; Mutation; Nitric Oxide Donors; Nitroso Compounds; Oxidants; Oxidoreductases; Protozoan Proteins; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2009
Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method.
    Analytica chimica acta, 2009, Aug-19, Volume: 648, Issue:1

    Topics: Adult; Biomarkers; Biopterins; Child; Chromatography, High Pressure Liquid; Female; Fluorescent Dyes; Humans; Infectious Mononucleosis; Male; Phenylketonurias; Pteridines

2009
Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
    Journal of inherited metabolic disease, 2010, Volume: 33, Issue:Suppl 2

    Topics: Biomarkers; Biopterins; Dihydropteridine Reductase; GTP Cyclohydrolase; Humans; Hydro-Lyases; Infant, Newborn; Metabolism, Inborn Errors; Neonatal Screening; Phenylalanine; Phenylketonurias; Predictive Value of Tests; Prognosis; Pteridines

2010
The tetrahydrobiopterin pathway: a novel target for the treatment of depression.
    Pharmacogenomics, 2011, Volume: 12, Issue:12

    Topics: Antidepressive Agents; Biopterins; Depressive Disorder; Humans; Metabolic Networks and Pathways; Norepinephrine; Pteridines; Serotonin

2011
HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation.
    Archives of biochemistry and biophysics, 2012, Apr-01, Volume: 520, Issue:1

    Topics: Biopterins; Chromatography, High Pressure Liquid; Electrochemistry; Fluorometry; Oxidation-Reduction; Pteridines

2012