pteridines and neopterin

pteridines has been researched along with neopterin in 172 studies

Research

Studies (172)

TimeframeStudies, this research(%)All Research%
pre-1990109 (63.37)18.7374
1990's37 (21.51)18.2507
2000's23 (13.37)29.6817
2010's1 (0.58)24.3611
2020's2 (1.16)2.80

Authors

AuthorsStudies
Eto, I; Fukushima, K; Shiota, T1
Hirayama, K; Katoh, S; Masuda, I; Nakanishi, N; Sueoka, T; Yamada, S1
Icho, T; Kajiwara, Y; Kojima, S; Kubota, K1
Reibnegger, G; Werner, ER; Werner-Felmayer, G1
Ambach, E; Bodner, E; Fuchs, D; Glaser, K; Kronberger, P; Wachter, H; Weiss, G1
Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G1
Dierich, MP; Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G1
Fuchs, D; Reibnegger, G; Wachter, H; Werner, ER1
Dierich, MP; Fuchs, D; Möst, J; Sölder, B; Wachter, H; Weyrer, W1
Curtius, HC; Dahinden, R; Ghisla, S; Kuster, T; Leimbacher, W; Raschdorf, F; Richter, WJ; Steinerstauch, P1
Hofbauer, J; Kratzik, C; Kuzmits, R; Legenstein, E; Ludwig, H; Szekeresz, T1
Bacher, A; Katzenmaier, G; Kerler, F; Le Van, Q; Schmid, C; Schwarzkopf, B; Ziegler, I1
Fuchs, D; Goedert, JJ; Kaufman, S; Krämer, A; Milstien, S; Reibnegger, G; Wachter, H; Werner, ER1
Katoh, S; Matsuura, S; Sueoka, T; Sugimoto, T1
Ferre, J; Jacobson, KB; Naylor, EW1
Beth-Giraldo, E; Chirianni, A; De Mercato, R; Giraldo, G; Levy, JA; Marfella, A; Nitsch, F; Perna, M; Piazza, M; Santelli, G1
Abita, JP; Cost, H; Kaufman, S; Milstien, S; Saimot, G1
Gerstner, L; Haas, R1
Albert, E; Fuchs, D; Hausen, A; Huber, C; Margreiter, R; Niederwieser, D; Reibnegger, G; Schönitzer, D; Troppmair, J; Wachter, H1
Curtius, HC; Heintel, D; Leimbacher, W; Redweik, U; Zagalak, B1
Curtius, HC; Leimbacher, W; Leupold, D; Niederwieser, A; Ponzone, A; Rey, F1
Bettex, JD; Blau, N; Hirschel, B; Joller, P; Lüthy, R; Niederwieser, A; Prader, A; Schaedelin, J; Seger, R; Vetter, U1
Flener, R; Huber, C; Kovarik, J; Leiter, E; Margreiter, R; Pohanka, E; Schwarz, M; Troppmair, J; Woloszczuk, W1
Borchert, M; Seidl, J; Ziegler, I1
Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER1
Fuchs, D; Hausen, A; Pilz, P; Reibnegger, G; Wachter, H; Wessely, K1
Bacher, A; Katzenmeier, G; Le Van, Q; Schmid, C; Schwarzkopf, B1
Alam, A; Shen, RS; Zhang, YX1
Bosshard, R; Leimbacher, W; Neuheiser, F; Redweik, U; Zagalak, B1
Blair, JA; Heales, SJ; Meinschad, C; Ziegler, I1
Diezel, W; Falck, P; Rabe, H; Sönnichsen, N; Volk, HD; von Baehr, R1
Daniel, V; Dreikorn, K; Opelz, G; Schäfer, AJ1
Bollbach, R; Fuchs, D; Hausen, A; Judmaier, G; Niederwieser, D; Prior, C; Reibnegger, G; Rotthauwe, HW; Wachter, H; Werner, ER1
Burns, RS; Eldridge, R; Levine, RA; LeWitt, PA; Lovenberg, W; Miller, LP; Newman, RP; Papavasiliou, A; Rayes, A1
Abate, G; Comella, P; Marfella, A; Nitsch, F; Perna, M; Santelli, G1
Akino, M; Horikoshi, T; Masada, M; Matsuura, S; Nagatsu, T; Sawada, M; Sugimoto, T1
Andrysek, O; Cernovská, I; Vasícková, M; Zitko, M1
Hakola, M; Hannonen, P; Möttönen, T; Oka, M; Tikanoja, S; Viinikka, L1
Egg, D; Fuchs, D; Günther, R; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER1
Delcroix, M; Dhondt, JL; Farriaux, JP; Forzy, G; Hayte, JM1
Applegarth, DA; Davidson, AG; Ennis, D; Naylor, EW; Niederwieser, A; Wong, LT1
Boudha, A; Dhondt, JL; Farriaux, JP; Largillière, C; Leeming, RJ; Ringel, J; Roger, MM1
Aulitzky, W; Frick, J; Fuchs, D; Hausen, A; Joos, H; Reibnegger, G; Wachter, H1
Balemans, MG; de Morée, A; Ebels, I; Mans, DR; van Benthem, J1
Ekman, P; Eneroth, P; Eriksson, A; Lewenhaupt, A; Nordström, L1
Akino, M; Katoh, S; Masada, M; Sueoka, T1
Fuchs, D; Hausen, A; Huber, C; König, P; Margreiter, R; Reibnegger, G; Wachter, H1
Bontoux, D; Bounaud, MP; Mura, P; Reiss, D; Tallineau, C; Thomas, P1
Krungkrai, J; Webster, HK; Yuthavong, Y1
Brown, GM; Switchenko, AC1
Curtius, HC; Ghisla, S; Heintel, D; Kuster, T; Leimbacher, W; Niederwieser, A1
Güttler, F; Lou, HC; Lykkelund, C; Niederwieser, A; Rasmussen, V1
Ziegler, I1
Bichler, AH; Dapunt, O; Fuchs, DN; Fuith, LC; Hausen, A; Hetzel, HM; Lutz, H; Reibnegger, GJ; Wachter, H; Werner, ER1
Gaull, GE; Matsubara, Y1
Aulitzky, W; Frick, J; Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H1
Cotlier, E; Rao, GN1
Kaufman, S; Milstien, S1
Bichler, A; Fuchs, D; Hausen, A; Hetzel, H; Reibnegger, G; Wachter, H3
Fuchs, D; Hausen, A; Huber, C; Judmaier, G; Niederwieser, D; Reibnegger, G; Wachter, H1
Duch, DS; Garbutt, JC; Nichol, CA; Woolf, JH1
Fuchs, D; Granditsch, G; Hausen, A; Reibnegger, G; Wachter, H1
Hanley, WB; Kapatos, G; Kaufman, S; MacGregor, D; McInnes, RR; Milstien, S; Soldin, S; Van Loon, GR; Walsh, P; Warsh, JJ1
Berlow, S; Hoganson, G; Kaufman, S; Matalon, R; Milstien, S; Naylor, E; Schuett, V; Seifert, W1
Balemans, MG; de Moree, A; Ebels, I; Legerstee, WC; Noteborn, HJ; Van Benthem, J1
Balemans, MG; de Moreé, A; Ebels, I; Hendriks, HG; van Berlo, M1
Fuchs, D; Hausen, A; Huber, C; Margreiter, R; Reibnegger, G; Spielberger, M; Wachter, H2
Dietrich, M; Kern, P; Rokos, H1
Matsuura, S; Nagatsu, T; Sawada, M; Sugimoto, T; Yamaguchi, T1
Ferre, J; Jacobson, KB1
Bannert, P; Fuchs, D; Gratwohl, A; Hausen, A; Huber, C; Niederwieser, D; Reibnegger, G; Speck, B; Wachter, H1
Brown, GM; Paton, DR; Wiederrecht, GJ1
Akino, M; Arashima, S; Kawaguchi, M; Masada, M; Matsuo, N; Mizokami, T; Seki, T; Tsuchiya, T; Yoshida, T; Yoshioka, S1
Brown, GM; Primus, JP; Switchenko, AC1
Batchelor, JR; Fuchs, D; Hausen, A; Huber, C; Lang, A; Niederwieser, D; Reibnegger, G; Swetly, P; Troppmair, J; Wachter, H1
Ebels, I; l'Hélias, C; Proust, J; Salemink, CA1
Brown, GM; Wiederrecht, GJ1
Güttler, F; Lou, H; Lykkelund, C; Niederwieser, A1
Boonpucknavig, V; Fuchs, D; Hausen, A; Reibnegger, G; Schmutzhard, E; Wachter, H1
Bowers, SW; Duch, DS; Nichol, CA; Woolf, JH1
Akino, M; Matsuura, S; Nagatsu, T; Nakazawa, N; Ogawa, H; Sawada, M; Sugimoto, T; Yamaguchi, T1
Fuchs, D; Hausen, A; Huber, C; Reibnegger, G; Wachter, H1
Fuchs, D; Hausen, A; Kofler, M; Kosanowski, H; Reibnegger, G; Wachter, H1
Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H1
Davidson, JR; Duch, DS; Garbutt, JC; Nichol, CA; Woolf, JH1
Huber, C; Niederwieser, D; Wachter, H1
Fuchs, D; Hausen, A; Huber, C; Niederwieser, D; Nilsson, K; Reibnegger, G; Wachter, H1
Fuchs, D; Hausen, A; Huber, C; Knosp, O; Reibnegger, G; Spira, TJ; Wachter, H1
Nichol, CA; Smith, GK1
Dhondt, JL; Farriaux, JP; Largilliere, C; Leeming, RJ; Leroux, B1
Heininger, JA; Lin, YY; Matsubara, Y1
Bellahsene, Z; Dhondt, JL; Farriaux, JP1
Fuchs, D; Hausen, A; Reibnegger, G; Reissigl, H; Schönitzer, D; Spira, T; Wachter, H1
Matalon, R1
Atarés, M; Blau, N; Cardesa-Garcia, J; Joller, P; Niederwieser, A; Wang, M1
Wainwright, LK; Wainwright, SD1
Barford, PA; Blair, JA; Eggar, C; Hamon, C; Morar, C; Whitburn, SB1
Smith, RA; Stea, B1
Ardouin, P; Dautrevaux, M; Dhondt, JL; Farriaux, JP; Largilliere, C1
Akino, M; Inoue, K; Masada, M; Mizokami, T; Yoshida, T; Yoshioka, SI1
Blau, N; Niederwieser, A1
Duch, DS; Nichol, CA; Woolf, JH1
Fukushima, T1
Fuchs, D; Hausen, A; König, K; Wachter, H1
Fuchs, D; Grünewald, K; Hausen, A; Huber, H; König, K; Wachter, H2
Bichler, A; Fuchs, D; Hausen, A; Hetzel, H; König, K; Wachter, H1
Curtius, HC; Leupold, D; Niederwieser, A; Wang, M1
Kapatos, G; Kaufman, S; McInnes, RR; Rizzo, WB; Schulman, JD1
Dorsett, D; Flanagan, JM; Jacobson, KB1
Ardouin, P; Dhondt, JL; Farriaux, JP; Hayte, JM1
Frisius, H; Kirstaedter, HJ; Rokos, H; Rokos, K1
Bartholomé, K; Kaufman, S; Lee, CL; Milstien, S; Nixon, JC1
Esterbauer, H; Gieseg, SP; Reibnegger, G; Wachter, H1
Bacher, A; Huber, R; Meining, W; Nar, H; Schmid, C; Weinkauf, S1
Baier-Bitterlich, G; Fuchs, D; Hausen, A; Murr, C; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G1
Fuchs, D; Hausen, A; Reibnegger, G; Schmidt, K; Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G1
Baier-Bitterlich, G; Böck, G; Dierich, MP; Fuchs, D; Murr, C; Reibnegger, G; Sgonc, R; Wachter, H; Werner-Felmayer, G1
De Saizieu, A; van Loon, AP; Vankan, P1
Fuchs, D; Grunicke, HH; Schubert, C; Uberall, F; Wachter, H; Werner-Felmayer, G1
Dierich, MP; Fuchs, D; Hausen, A; Reibnegger, G; Semenitz, E; Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G1
Fuchs, D; Lang, F; Wachter, H; Weiss, G; Wöll, E1
Fuchs, D; Grote, J; Hoffmann, G; Schobersberger, W; Wachter, H1
Baier-Bitterlich, G; Fuchs, D; Wachter, H2
Baier-Bitterlich, G; Esterbauer, H; Fuchs, D; Murr, C; Pfleiderer, W; Wachter, H; Werner, ER1
Baier, G; Baier-Bitterlich, G; Böck, G; Fuchs, D; Hausen, A; Pavelka, M; Utermann, G; Wachter, H1
Baier-Bitterlich, G; Bock, G; Fuchs, D; Hobisch-Hagen, P; Hoffmann, G; Schobersberger, W; Volkl, H; Wachter, H; Wirleitner, B1
Bacher, A; Eberhardt, S; Haussmann, C; Lottspeich, F; Mackamul, S; Rohdich, F; Scheuring, J1
Baeuerle, PA; Baier, G; Baier-Bitterlich, G; Fresser, F; Fuchs, D; Uberall, F; Wachter, H; Werner, ER; Zangerle, R1
Arai, T; Makino, K; Mori, H; Mori, K; Nakao, S; Suzuki, T; Tajima, K; Watanabe, K1
Baier-Bitterlich, G; Fuchs, D; Hoffmann, G; Schobersberger, W; Wachter, H; Wirleitner, B1
Dikalov, S; Freisleben, HJ; Mlekusch, W; Oettl, K; Reibnegger, G1
Howell, DM; White, RH1
Baier-Bitterlich, G; Fuchs, D; Wede, I; Widner, B; Wirleitner, B1
Durán-Merás, I; Espinosa-Mansilla, A; Salinas, F1
Baier-Bitterlich, G; Böck, G; Fuchs, D; Widner, B; Wirleitner, B1
Oettl, K; Reibnegger, G1
Auerbach, G; Bacher, A; Boyle, P; Bracher, A; Eisenreich, W; Fischer, M; Gentili, P; Huber, R; Nar, H; Ritz, H; Schramek, N1
Fandrey, J; Fuchs, D; Jelkmann, W; Pagel, H; Schobersberger, W1
Baier-Bitterlich, G; Fuchs, D; Grammer, T; Oettl, K; Reibnegger, G; Wirleitner, B1
Fuchs, D; Wede, I; Widner, B1
Gieseg, SP; Glubb, D; Maghzal, G2
Fuchs, D; Mayr, C; Widner, B; Wirleitner, B1
Bacher, A; Bracher, A; Schramek, N1
Dierich, MP; Fuchs, D; Lass-Flörl, C; Mohsenipour, I; Speth, C; Stöckl, G; Widner, B; Wirleitner, B; Würzner, R1
Baier, G; Baier-Bitterlich, G; Böck, G; Czaputa, R; Fuchs, D; Oettl, K; Reibnegger, G; Widner, B; Wirleitner, B1
Duggan, S; Gebicki, JM; Gieseg, SP; Rait, C1
Gieseg, SP; Glubb, D; Rait, C; Whybrow, J1
Baier-Bitterlich, G; Böck, G; Enzinger, C; Fuchs, D; Wirleitner, B1
Auerbach, G; Bacher, A; Bracher, A; Fischer, M; Huber, R; Nar, H; Schramek, N1
Fuchs, D; Murr, C; Widner, B; Wirleitner, B1
Baier, G; Baier-Bitterlich, G; Böck, G; Enzinger, C; Fuchs, D; Lutz, C; Tomaselli, B; Wirleitner, B1
Hosoya, T; Nakayama, M; Sakagami, H; Tajima, M; Tokutome, G; Yokoyama, K; Yoshida, H1
Horejsi, R; Jung, C; Möller, R; Reibnegger, G; Tafeit, E1
Fuchs, D; Greilberger, J; Herpfer, I; Jürgens, G; Ledinski, G; Widner, B1
Duggan, S; Gieseg, S; Platt, A; Rait, C1
Auerbach, G; Bacher, A; Bader, G; Bracher, A; Fischer, M; Hösl, C; Huber, R; Kaiser, J; Nar, H; Rebelo, J; Schramek, N1
Böck, G; Fuchs, D; Neurauter, G; Obermoser, G; Schennach, H; Sepp, N; Wirleitner, B1
Fekkes, D; Hoekstra, R; Pepplinkhuizen, L; van de Wetering, BJ; Verhoeven, WM1
Bannink, M; Eggermont, AM; Fekkes, D; Kruit, WH; Mulder, PG; Stoter, G; Van Gool, AR; van Ojik, HH1
Gregory, JF; Hanson, AD; Hugenholtz, J; Klaus, SM; Sybesma, W; Wegkamp, A1
Engin, AB; Sahin, G; Tuzun, D1
Bandarian, V; McCarty, RM; Somogyi, A1
Hunakova, L; Martinicky, D; Sikurova, L; Zvarik, M1
Bartoli, F; Capogrosso, CA; Carrà, G; Cavaleri, D; Crocamo, C; Fuchs, D; Guzzi, P; Kishi, T; Misiak, B; Moretti, F; Riboldi, I; Rubin, RT1
Aktuglu-Zeybek, C; Cansever, MS; Cebi, MN; Isat, E; Kiykim, E; Oge-Enver, E; Yilmaz, G; Zubarioglu, T1

Reviews

6 review(s) available for pteridines and neopterin

ArticleYear
Immune activation and the anaemia associated with chronic inflammatory disorders.
    European journal of haematology, 1991, Volume: 46, Issue:2

    Topics: Anemia; Animals; Biopterins; Chronic Disease; Cytokines; Hematopoiesis; Humans; Immunity, Cellular; Inflammation; Interferon-gamma; Neopterin; Pteridines

1991
Neopterins in clinical medicine.
    Lancet (London, England), 1988, Mar-05, Volume: 1, Issue:8584

    Topics: Biopterins; Humans; Neopterin; Predictive Value of Tests; Pteridines

1988
Biosynthesis of tetrahydrobiopterin in man.
    Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 1

    Topics: Alcohol Oxidoreductases; Biopterins; Deuterium; Humans; In Vitro Techniques; Liver; Neopterin; Pteridines; Tetrahydrofolate Dehydrogenase

1985
Urinary unconjugated pteridines: general considerations.
    Survey of immunologic research, 1982, Volume: 1, Issue:4

    Topics: Animals; Biopterins; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cricetinae; Humans; Male; Mice; Neoplasms; Neopterin; Pteridines; Rats; Xanthopterin

1982
Neopterin as a marker for immune system activation.
    Current drug metabolism, 2002, Volume: 3, Issue:2

    Topics: Animals; Biomarkers; Humans; Immune System; Infections; Neoplasms; Neopterin; Pteridines

2002
Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis.
    Progress in neuro-psychopharmacology & biological psychiatry, 2023, 01-10, Volume: 120

    Topics: Biopterins; Depression; Depressive Disorder, Major; Humans; Neopterin; Pteridines

2023

Trials

2 trial(s) available for pteridines and neopterin

ArticleYear
Effect of light therapy on biopterin, neopterin and tryptophan in patients with seasonal affective disorder.
    Psychiatry research, 2003, Aug-30, Volume: 120, Issue:1

    Topics: Adult; Biopterins; Female; Humans; Immunity, Cellular; Male; Middle Aged; Neopterin; Personality Inventory; Phototherapy; Pteridines; Reference Values; Seasonal Affective Disorder; Seasons; Serotonin; Tryptophan

2003
Pegylated interferon-alpha2b treatment in melanoma patients: influence on amino acids, 5-hydroxyindolacetic acid and pteridine plasma concentrations.
    Anti-cancer drugs, 2004, Volume: 15, Issue:6

    Topics: Adult; Aged; Amino Acids; Biopterins; Drug Administration Schedule; Female; Humans; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Interferon alpha-2; Interferon-alpha; Male; Melanoma; Middle Aged; Neopterin; Phenylalanine; Pilot Projects; Polyethylene Glycols; Pteridines; Randomized Controlled Trials as Topic; Recombinant Proteins; Time Factors; Tryptophan; Tyrosine

2004

Other Studies

164 other study(ies) available for pteridines and neopterin

ArticleYear
Enzymatic synthesis of biopterin from D-erythrodihydroneopterin triphosphate by extracts of kidneys from Syrian golden hamsters.
    The Journal of biological chemistry, 1976, Nov-10, Volume: 251, Issue:21

    Topics: Animals; Biological Assay; Biopterins; Brain; Cricetinae; Eukaryota; Kidney; Kinetics; Liver; Lung; Mesocricetus; NAD; NADP; Neopterin; Organ Specificity; Organophosphorus Compounds; Oxidation-Reduction; Pteridines; Pterins; Spectrometry, Fluorescence

1976
[Isolation and stereostructural determination of neopterin (2-amino-4-hydroxy-6-trihydroxypropyl pteridine) from Drosophila melanogaster (author's transl)].
    Josai Shika Daigaku kiyo. The Bulletin of the Josai Dental University, 1979, Volume: 8, Issue:1

    Topics: Animals; Biopterins; Chromatography, Paper; Drosophila melanogaster; Neopterin; Pteridines

1979
Neopterin as an endogenous antioxidant.
    FEBS letters, 1992, Jun-15, Volume: 304, Issue:2-3

    Topics: Alloxan; Animals; Antioxidants; Biopterins; Blood Glucose; Diabetes Mellitus, Experimental; Male; Mice; Neopterin; Pteridines; Superoxide Dismutase; Superoxides; Xanthine Oxidase

1992
Enzymatic cleavage of guanosine triphosphate (GTP) by GTP cyclohydrolase I.
    Scandinavian journal of clinical and laboratory investigation, 1992, Volume: 52, Issue:1

    Topics: Biopterins; GTP Cyclohydrolase; Guanosine Triphosphate; Humans; Neopterin; Pteridines

1992
Distinct distributions of D-erythro-neopterin in arteries and veins and its recovery by an enterohepatic circulation.
    Biological chemistry Hoppe-Seyler, 1992, Volume: 373, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Arteries; Bile; Biopterins; Duodenal Ulcer; Enterohepatic Circulation; Feces; Humans; Liver; Male; Middle Aged; Neopterin; Pteridines; Stomach Neoplasms; Veins

1992
Relationships between pteridine synthesis and tryptophan degradation.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Biopterins; Cells, Cultured; Enzyme Induction; Humans; Hydrolases; Interferon-gamma; Macrophages; NAD; Neopterin; Pteridines; Tryptophan; Tryptophan Oxygenase

1991
Increased 7,8-dihydroneopterin and reduced methyl-group metabolism in HIV-1 infection.
    Lancet (London, England), 1990, May-12, Volume: 335, Issue:8698

    Topics: Acquired Immunodeficiency Syndrome; Biological Availability; Child; Humans; Neopterin; Pteridines; Tetrahydrofolates

1990
Production and characterization of a monoclonal antibody against neopterin.
    Hybridoma, 1990, Volume: 9, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Biopterins; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Hybridomas; Mice; Neopterin; Pteridines; Radioimmunoassay

1990
1H-NMR and mass spectrometric studies of tetrahydropterins. Evidence for the structure of 6-pyruvoyl tetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin.
    European journal of biochemistry, 1990, Feb-14, Volume: 187, Issue:3

    Topics: Alcohol Oxidoreductases; Biopterins; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Neopterin; Oxidation-Reduction; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Stereoisomerism

1990
Neopterin as tumour marker serum and urinary neopterin concentrations in malignant diseases.
    Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1986, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Aged; alpha-Fetoproteins; Biopterins; Chorionic Gonadotropin; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Neoplasms; Neopterin; Pteridines; Radioimmunoassay; Testicular Neoplasms

1986
Biosynthesis of tetrahydrobiopterin: a sensitive assay of 6-pyruvoyltetrahydropterin synthase using [2'-3H]dihydroneopterin 3'-triphosphate as substrate.
    Biochimica et biophysica acta, 1989, Jan-27, Volume: 990, Issue:1

    Topics: Adsorption; Alcohol Oxidoreductases; Animals; Biopterins; Charcoal; Chemical Phenomena; Chemistry; Edetic Acid; Escherichia coli; Liver; Magnesium; Mice; Neopterin; Phosphorus-Oxygen Lyases; Pteridines; Tritium

1989
Urinary neopterin concentrations vs total neopterins for clinical utility.
    Clinical chemistry, 1989, Volume: 35, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, CD; Biopterins; HIV Seropositivity; Homosexuality; Humans; Male; Neopterin; Pteridines; T-Lymphocytes

1989
Biopterin and neopterin in human saliva.
    Life sciences, 1989, Volume: 45, Issue:26

    Topics: Adult; Biopterins; Chromatography, High Pressure Liquid; Female; Humans; Male; Neopterin; Oxidation-Reduction; Potassium Permanganate; Pteridines; Pterins; Saliva; Sex Factors

1989
Repetitive recycling of guanosine triphosphate cyclohydrolase I for synthesis of dihydroneopterin triphosphate.
    Analytical biochemistry, 1989, Volume: 176, Issue:1

    Topics: Aminohydrolases; Escherichia coli; GTP Cyclohydrolase; Indicators and Reagents; Neopterin; Pteridines

1989
Urinary neopterin, a useful marker for AIDS?
    Lancet (London, England), 1985, May-04, Volume: 1, Issue:8436

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Biopterins; Humans; Neopterin; Pteridines

1985
Urinary neopterin and biopterin levels in patients with AIDS and AIDS-related complex.
    Lancet (London, England), 1985, Jul-06, Volume: 2, Issue:8445

    Topics: Acquired Immunodeficiency Syndrome; Adult; Biopterins; Humans; Neopterin; Pteridines

1985
[Radioimmunological determination of neopterin in blood donors].
    Allergie und Immunologie, 1985, Volume: 31, Issue:3

    Topics: Adolescent; Adult; Biopterins; Blood Donors; Female; Humans; Male; Neopterin; Pteridines; Radioimmunoassay; Respiratory Tract Infections; Sex Factors; Virus Diseases

1985
Neopterin release in human mixed lymphocyte culture: requirement of HLA-DR disparity.
    Immunology letters, 1985, Volume: 11, Issue:2

    Topics: Biopterins; Female; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Male; Neopterin; Phenotype; Pteridines; T-Lymphocytes, Helper-Inducer

1985
Purification and properties of the phosphate eliminating enzyme involved in the biosynthesis of BH4 in man.
    Biochemical and biophysical research communications, 1985, Feb-28, Volume: 127, Issue:1

    Topics: Biopterins; Humans; Isoelectric Point; Liver; Magnesium; Molecular Weight; NADP; Neopterin; Pteridines; Pyrophosphatases; Temperature; Time Factors

1985
Atypical phenylketonuria with "dihydrobiopterin synthetase" deficiency: absence of phosphate-eliminating enzyme activity demonstrated in liver.
    European journal of pediatrics, 1985, Volume: 144, Issue:1

    Topics: Adult; Alcohol Oxidoreductases; Biopterins; Chemical Phenomena; Chemistry; Child; Child, Preschool; Female; Humans; Infant; Liver; Male; Neopterin; Phenylketonurias; Pteridines; Pyrophosphatases

1985
Neopterin in AIDs, other immunodeficiencies, and bacterial and viral infections.
    Klinische Wochenschrift, 1986, Apr-01, Volume: 64, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Bacterial Infections; Biopterins; Child; Child, Preschool; Deltaretrovirus; Female; Homosexuality; Humans; Immunologic Deficiency Syndromes; Infant; Lymphatic Diseases; Male; Neopterin; Pteridines; Retroviridae Infections; Virus Diseases

1986
Relationship of interferon-gamma and neopterin levels during stimulation with alloantigens in vivo and in vitro.
    Transplantation, 1986, Volume: 41, Issue:6

    Topics: Acute Disease; Biopterins; Graft Rejection; Humans; Infections; Interferon-gamma; Isoantigens; Kidney Transplantation; Lymphocyte Activation; Neopterin; Phytohemagglutinins; Pteridines

1986
Phorbol ester causes short term and transient accumulation of pteridines in T cells and in cell lines.
    Biochemical and biophysical research communications, 1986, Dec-15, Volume: 141, Issue:2

    Topics: Biopterins; Cell Line; Humans; Kinetics; Lymphocyte Activation; Neopterin; Protein Kinase C; Pteridines; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate

1986
Simultaneous determination of neopterin and creatinine in serum with solid-phase extraction and on-line elution liquid chromatography.
    Clinical chemistry, 1987, Volume: 33, Issue:11

    Topics: Adult; Biopterins; Chromatography, High Pressure Liquid; Creatinine; Edetic Acid; Female; Ferric Compounds; Humans; Kidney Transplantation; Male; Middle Aged; Neopterin; Pteridines; Quality Control; Radioimmunoassay; Reference Values

1987
[1st case of AIDS in Salzburg. Important diagnostic hint by determination of neopterin].
    Wiener klinische Wochenschrift, 1985, Jan-18, Volume: 97, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Austria; Biopterins; Blood Sedimentation; Humans; Lymphocytes; Male; Middle Aged; Neopterin; Pteridines; Respiratory Insufficiency; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory

1985
Biosynthesis of biopterin. Studies on the mechanism of 6-pyruvoyltetrahydropteridine synthase.
    Biochemical and biophysical research communications, 1988, Feb-29, Volume: 151, Issue:1

    Topics: Alcohol Oxidoreductases; Animals; Biopterins; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Neopterin; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Substrate Specificity

1988
Inhibition of GTP cyclohydrolase I by pterins.
    Biochimica et biophysica acta, 1988, Apr-14, Volume: 965, Issue:1

    Topics: Aminohydrolases; Animals; Biopterins; Folic Acid; GTP Cyclohydrolase; Kinetics; Liver; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Rats; Xanthopterin

1988
Synthesis of enzymatically active D-7,8-dihydroneopterin-3'-triphosphate.
    Biochemical and biophysical research communications, 1988, May-16, Volume: 152, Issue:3

    Topics: Biopterins; Methods; Neopterin; Pteridines

1988
Inhibition of monocyte luminol-dependent chemiluminescence by tetrahydrobiopterin, and the free radical oxidation of tetrahydrobiopterin, dihydrobiopterin and dihydroneopterin.
    Cell biochemistry and function, 1988, Volume: 6, Issue:3

    Topics: Ascorbic Acid; Biopterins; Dithioerythritol; Free Radicals; Humans; Hydrogen Peroxide; In Vitro Techniques; Luminescent Measurements; Macrophages; Monocytes; Neopterin; Oxidation-Reduction; Pteridines

1988
[Quantitative determination of neopterin concentration in urine--a parameter for the detection of the immunologic activity of T lymphocytes in skin diseases].
    Dermatologische Monatschrift, 1986, Volume: 172, Issue:5

    Topics: Biopterins; Chromatography, High Pressure Liquid; Humans; Lymphocyte Activation; Neopterin; Pteridines; Skin Diseases; T-Lymphocytes

1986
Assessment of plasma neopterin in clinical kidney transplantation.
    Transplantation, 1986, Volume: 41, Issue:4

    Topics: Biopterins; Blood Urea Nitrogen; Cortisone; Creatinine; Graft Rejection; Humans; Kidney; Kidney Transplantation; Neopterin; Pteridines; Radioimmunoassay; Time Factors

1986
Urinary neopterin, a marker of clinical activity in patients with Crohn's disease.
    Clinica chimica acta; international journal of clinical chemistry, 1986, Feb-28, Volume: 155, Issue:1

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Biopterins; Child; Crohn Disease; Female; Hematocrit; Humans; Male; Middle Aged; Neopterin; Pteridines; Regression Analysis

1986
Tetrahydrobiopterin in dystonia: identification of abnormal metabolism and therapeutic trials.
    Neurology, 1986, Volume: 36, Issue:6

    Topics: Adult; Aged; Biopterins; Dystonia; Female; Humans; Male; Middle Aged; Neopterin; Pteridines

1986
Urinary neopterin levels in hematologic malignancies.
    Tumori, 1986, Apr-30, Volume: 72, Issue:2

    Topics: Adolescent; Adult; Aged; Biopterins; Child; Female; Hodgkin Disease; Humans; Lymphoma; Male; Middle Aged; Multiple Myeloma; Neopterin; Pteridines

1986
A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin.
    Analytical biochemistry, 1986, Volume: 154, Issue:1

    Topics: Aminohydrolases; Animals; Biopterins; Brain; Caudate Nucleus; GTP Cyclohydrolase; Humans; Male; Neopterin; Parkinson Disease; Pteridines; Radioimmunoassay; Rats; Rats, Inbred Strains; Tissue Distribution

1986
Renal excretion of neopterine and biopterine in patients with malignant melanoma and Hodgkin's disease.
    Neoplasma, 1986, Volume: 33, Issue:3

    Topics: Biopterins; Chromatography, Thin Layer; Female; Hodgkin Disease; Humans; Kidney; Male; Melanoma; Neopterin; Pteridines

1986
Urinary neopterin index as a measure of rheumatoid activity.
    Scandinavian journal of rheumatology, 1986, Volume: 15, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Biopterins; Bone Diseases; Diagnosis, Differential; Female; Humans; Joint Diseases; Male; Middle Aged; Neopterin; Pain; Pteridines

1986
Urinary neopterin reflects clinical activity in patients with rheumatoid arthritis.
    Arthritis and rheumatism, 1986, Volume: 29, Issue:9

    Topics: Aged; Arthritis, Rheumatoid; Biopterins; Blood Sedimentation; C-Reactive Protein; Female; Humans; Immunity, Cellular; Male; Middle Aged; Neopterin; Osteoarthritis; Pteridines; Rheumatoid Factor

1986
Unconjugated pteridines in amniotic fluid during gestation.
    Clinica chimica acta; international journal of clinical chemistry, 1986, Dec-30, Volume: 161, Issue:3

    Topics: Amniotic Fluid; Biopterins; Creatinine; Female; Fetus; Gestational Age; Humans; Neopterin; Pregnancy; Pteridines

1986
Guanosine triphosphate cyclohydrolase I deficiency: early diagnosis by routine urine pteridine screening.
    Pediatrics, 1987, Volume: 79, Issue:3

    Topics: Aminohydrolases; Biopterins; Chromatography, High Pressure Liquid; Diagnosis, Differential; GTP Cyclohydrolase; Humans; Infant, Newborn; Liver; Male; Neopterin; Phenylalanine; Phenylketonurias; Pteridines

1987
Neonatal hyperphenylalaninemia presumably caused by guanosine triphosphate-cyclohydrolase deficiency.
    The Journal of pediatrics, 1985, Volume: 106, Issue:6

    Topics: Aminohydrolases; Biopterins; GTP Cyclohydrolase; Humans; Infant, Newborn; Leukocyte Count; Liver; Male; Neopterin; Phenylalanine; Pteridines; Pterins; T-Lymphocytes

1985
The value of urinary neopterin as an immunological parameter in patients with malignant tumors of the genitourinary tract.
    Urologia internationalis, 1985, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Aged; Biopterins; Carcinoma, Renal Cell; Chromatography, High Pressure Liquid; Dysgerminoma; Female; Humans; Kidney Neoplasms; Macrophages; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neopterin; Prognosis; Prostatic Neoplasms; Pteridines; T-Lymphocytes; Testicular Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms

1985
The effect of reduced neopterin on the synthesis of several methylated indoles in the pineal gland of adult male golden hamsters, kept under standardized conditions.
    Journal of neural transmission, 1985, Volume: 62, Issue:1-2

    Topics: 5-Hydroxytryptophan; Animals; Biopterins; Cricetinae; Indoles; Male; Melatonin; Mesocricetus; Methylation; Neopterin; Pineal Gland; Pteridines; Tryptophan

1985
Serum levels of prostatic acid phosphatase (PAP), tissue polypeptide antigen (TPA), CA-50, neopterine and of osteocalcin in patients with prostatic carcinoma.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1985, Volume: 179

    Topics: Acid Phosphatase; Aged; Antigens, Neoplasm; Antigens, Tumor-Associated, Carbohydrate; Biopterins; Calcium-Binding Proteins; Clinical Enzyme Tests; Clinical Laboratory Techniques; Enzyme-Linked Immunosorbent Assay; Humans; Male; Methods; Middle Aged; Neopterin; Osteocalcin; Peptides; Prostate; Prostatic Neoplasms; Pteridines; Radioimmunoassay; Tissue Polypeptide Antigen; Vitamin K

1985
Dyspropterin, an intermediate formed from dihydroneopterin triphosphate in the biosynthetic pathway of tetrahydrobiopterin.
    Biochimica et biophysica acta, 1985, Jun-18, Volume: 840, Issue:2

    Topics: Alcohol Oxidoreductases; Biopterins; Catalysis; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydropteridine Reductase; Hydroxylation; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Spectrophotometry, Ultraviolet

1985
Neopterin levels in long-term renal allograft recipients.
    Immunobiology, 1985, Volume: 169, Issue:2

    Topics: Biopterins; Female; Graft Survival; Humans; Kidney Transplantation; Male; Neopterin; Prognosis; Pteridines; Time Factors

1985
[Value of the assay of urinary neopterin in multiple myeloma. Preliminary study].
    Revue du rhumatisme et des maladies osteo-articulaires, 1985, Volume: 52, Issue:6

    Topics: Aged; beta 2-Microglobulin; Biopterins; Chromatography, High Pressure Liquid; Female; Humans; Immunoglobulin A; Immunoglobulin G; Male; Middle Aged; Multiple Myeloma; Neopterin; Pteridines

1985
Guanosine triphosphate cyclohydrolase in Plasmodium falciparum and other Plasmodium species.
    Molecular and biochemical parasitology, 1985, Volume: 17, Issue:3

    Topics: Aminohydrolases; Animals; Chromatography, High Pressure Liquid; Erythrocytes; Folic Acid; Formates; GTP Cyclohydrolase; Kinetics; Neopterin; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Pteridines

1985
The enzymatic conversion of dihydroneopterin triphosphate to tripolyphosphate and 6-pyruvoyl-tetrahydropterin, an intermediate in the biosynthesis of other pterins in Drosophila melanogaster.
    The Journal of biological chemistry, 1985, Mar-10, Volume: 260, Issue:5

    Topics: Alcohol Oxidoreductases; Animals; Drosophila melanogaster; Kinetics; Magnesium; Neopterin; Phosphorus-Oxygen Lyases; Polyphosphates; Pteridines; Pterins

1985
Biopterin, neopterin and tyrosine responses to combined oral phenylalanine and tetrahydrobiopterin loading tests in two normal children and in a girl with partial biopterin deficiency.
    Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 2

    Topics: Administration, Oral; Biopterins; Child; Female; Humans; Neopterin; Phenylalanine; Pteridines; Tyrosine

1985
Synthesis and interferon-gamma controlled release of pteridines during activation of human peripheral blood mononuclear cells.
    Biochemical and biophysical research communications, 1985, Oct-15, Volume: 132, Issue:1

    Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; DNA Replication; Humans; Interferon-gamma; Iodine; Mice; Monocytes; Neopterin; Pteridines; Pterins; Time Factors

1985
Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix.
    Cancer research, 1986, Volume: 46, Issue:2

    Topics: Adenocarcinoma; Adult; Biopterins; Carcinoma, Squamous Cell; Female; Follow-Up Studies; Humans; Immunity, Cellular; Leiomyosarcoma; Middle Aged; Neopterin; Prognosis; Pteridines; Uterine Cervical Neoplasms

1986
Biopterin and neopterin in various milks and infant formulas.
    The American journal of clinical nutrition, 1985, Volume: 41, Issue:1

    Topics: Animals; Biopterins; Cats; Cattle; Chromatography, High Pressure Liquid; Female; Humans; Infant Food; Milk; Milk, Human; Neopterin; Pteridines; Rabbits; Rats; Species Specificity

1985
Significance of urinary neopterin in patients with malignant tumors of the genitourinary tract.
    Cancer, 1985, Mar-01, Volume: 55, Issue:5

    Topics: Adolescent; Adult; Aged; Biopterins; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neopterin; Prostatic Neoplasms; Pteridines; Urinary Bladder Neoplasms; Urogenital Neoplasms

1985
Biosynthesis of neopterin, sepiapterin, and biopterin in rat and human ocular tissues.
    Investigative ophthalmology & visual science, 1985, Volume: 26, Issue:5

    Topics: Animals; Biopterins; Ciliary Body; Eye; Humans; Iris; Lens, Crystalline; Neopterin; Pteridines; Pterins; Rats; Retina

1985
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates.
    Biochemical and biophysical research communications, 1985, May-16, Volume: 128, Issue:3

    Topics: Adrenal Medulla; Animals; Biopterins; Brain; Cattle; Chemical Phenomena; Chemistry; In Vitro Techniques; Kinetics; Liver; Neopterin; Pteridines; Pterins; Rats

1985
Neopterin, a biochemical indicator of cellular immune reactions, in the detection and control of patients with neoplastic diseases.
    Cancer detection and prevention, 1985, Volume: 8, Issue:1-2

    Topics: Adolescent; Adult; Aged; Biopterins; Female; Humans; Immunity, Cellular; Male; Middle Aged; Neoplasms; Neopterin; Pteridines

1985
Neopterin as a new biochemical marker in the clinical assessment of ulcerative colitis.
    Immunobiology, 1985, Volume: 170, Issue:4

    Topics: Adolescent; Adult; Biopterins; Colitis, Ulcerative; Female; Humans; Immunity, Cellular; Male; Middle Aged; Monitoring, Physiologic; Neopterin; Pteridines

1985
Urinary biopterin and neopterin excretion and pituitary-adrenal activity in psychiatric patients.
    Psychiatry research, 1985, Volume: 16, Issue:3

    Topics: Adult; Alcoholism; Biopterins; Depressive Disorder; Dexamethasone; Female; Humans; Male; Mental Disorders; Middle Aged; Neopterin; Personality Disorders; Pituitary-Adrenal System; Psychotic Disorders; Pteridines; Schizophrenia

1985
Urinary neopterin excretion in coeliac disease.
    Lancet (London, England), 1983, Aug-20, Volume: 2, Issue:8347

    Topics: Biopterins; Celiac Disease; Child; Chromatography, High Pressure Liquid; Glutens; Humans; Neopterin; Pteridines

1983
Biopterin synthesis defect. Treatment with L-dopa and 5-hydroxytryptophan compared with therapy with a tetrahydropterin.
    The Journal of clinical investigation, 1984, Volume: 73, Issue:2

    Topics: 5-Hydroxytryptophan; Amino Acid Metabolism, Inborn Errors; Biopterins; Carbidopa; Catecholamines; Dose-Response Relationship, Drug; Female; Humans; Infant; Levodopa; Neopterin; Neurotransmitter Agents; Pteridines; Pterins

1984
Biopterin synthesis defects: problems in diagnosis.
    Pediatrics, 1984, Volume: 74, Issue:6

    Topics: Biopterins; Diet; Female; Humans; Infant, Newborn; Metabolism, Inborn Errors; Neopterin; Neurotransmitter Agents; Phenylalanine; Pteridines

1984
The influence of some pterins on the circadian rhythmicity of hydroxyindole-O-methyl transferase in the pineal gland of 42-day old male Wistar rats.
    Reproduction, nutrition, developpement, 1980, Volume: 20, Issue:4A

    Topics: 5-Hydroxytryptophan; Acetylserotonin O-Methyltransferase; Animals; Biopterins; Circadian Rhythm; Hydroxyindoleacetic Acid; Hydroxytryptophol; Male; Methylation; Methyltransferases; Neopterin; Pteridines; Pterins; Rats; Rats, Inbred Strains; Serotonin; Xanthopterin

1980
The influence of some pteridines on pineal 5-methoxyindole synthesis in male Wistar rats periodically exposed to either white or green light.
    Journal of neural transmission, 1983, Volume: 58, Issue:1-2

    Topics: 5-Methoxytryptamine; Animals; Biopterins; Hydroxyindoleacetic Acid; Indoles; Light; Male; Melanins; Neopterin; Pineal Gland; Pteridines; Pterins; Rats; Rats, Inbred Strains; Tryptophan

1983
Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants.
    Journal of immunology (Baltimore, Md. : 1950), 1983, Volume: 130, Issue:3

    Topics: Adult; Biopterins; Cytomegalovirus Infections; Graft Rejection; HLA Antigens; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Lymphocyte Activation; Male; Middle Aged; Neopterin; Pteridines; T-Lymphocytes

1983
Raised serum neopterin levels and imbalances of T-lymphocyte subsets in viral diseases, acquired immune deficiency and related lymphadenopathy syndromes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1984, Volume: 38, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Adult; Biopterins; Humans; Lymphatic Diseases; Neopterin; Pteridines; T-Lymphocytes; Virus Diseases

1984
Neopterin as a new biochemical marker for diagnosis of allograft rejection. Experience based upon evaluation of 100 consecutive cases.
    Transplantation, 1983, Volume: 36, Issue:6

    Topics: Biopterins; Cyclosporins; Graft Rejection; Humans; Immune Tolerance; Kidney Transplantation; Liver Transplantation; Neopterin; Pancreas Transplantation; Pteridines; Transplantation, Homologous

1983
Polarization fluoroimmunoassay of biopterin and neopterin in human urine.
    Clinica chimica acta; international journal of clinical chemistry, 1984, Apr-27, Volume: 138, Issue:3

    Topics: Animals; Biopterins; Fluorescence Polarization; Fluorescent Antibody Technique; Humans; Immune Sera; Neopterin; Pteridines; Rabbits; Radioimmunoassay

1984
Formation of beta,gamma-methylene-7,8-dihydroneopterin 3'-triphosphate from beta,gamma-methyleneguanosine 5'-triphosphate by GTP cyclohydrolase I of Escherichia coli.
    Archives of biochemistry and biophysics, 1984, Volume: 233, Issue:2

    Topics: Aminohydrolases; Chemical Phenomena; Chemistry; Chromatography; Escherichia coli; GTP Cyclohydrolase; Guanosine Triphosphate; Neopterin; Pteridines; Spectrometry, Fluorescence; Substrate Specificity

1984
Neopterin as a new biochemical marker in the clinical monitoring of bone marrow transplant recipients.
    Transplantation, 1984, Volume: 38, Issue:5

    Topics: Biopterins; Bone Marrow Transplantation; Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neopterin; Pteridines

1984
Enzymatic conversion of dihydroneopterin triphosphate to the pyrimidodiazepine intermediate involved in the biosynthesis of the drosopterins in Drosophila melanogaster.
    The Journal of biological chemistry, 1984, Feb-25, Volume: 259, Issue:4

    Topics: Animals; Azepines; Chromatography, High Pressure Liquid; Drosophila melanogaster; Glutathione; Kinetics; Magnesium; Magnesium Chloride; Mercaptoethanol; Neopterin; Pteridines; Pterins

1984
A defective enzyme in hyperphenylalaninaemia due to biopterin deficiency.
    Journal of inherited metabolic disease, 1983, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Erythrocytes; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Multienzyme Complexes; Neopterin; Phenylalanine; Pteridines

1983
Intermediates in the enzymic synthesis of tetrahydrobiopterin in Drosophila melanogaster.
    Biochemical and biophysical research communications, 1984, May-16, Volume: 120, Issue:3

    Topics: Animals; Biopterins; Biotransformation; Catalysis; Drosophila melanogaster; Edetic Acid; Magnesium; NADP; Neopterin; Pteridines; Pterins

1984
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.
    The Journal of experimental medicine, 1984, Jul-01, Volume: 160, Issue:1

    Topics: Biopterins; Humans; Interferon-gamma; Lymphocyte Activation; Macrophage Activation; Macrophages; Monocytes; Neopterin; Pteridines; T-Lymphocytes

1984
Lethal mutations induced in Drosophila melanogaster by direct or indirect action of pteridines.
    Mutation research, 1984, Volume: 128, Issue:2

    Topics: Animals; Biopterins; Drosophila melanogaster; Genes, Lethal; Genes, Recessive; Lepidoptera; Mutagenicity Tests; Mutagens; Mutation; Neopterin; Pteridines; Tissue Extracts

1984
Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins.
    The Journal of biological chemistry, 1984, Nov-25, Volume: 259, Issue:22

    Topics: Alcohol Oxidoreductases; Animals; Azepines; Chromatography, Gel; Chromatography, Ion Exchange; Drosophila melanogaster; Eye Color; Ketone Oxidoreductases; Mutation; Neopterin; Phosphorus-Oxygen Lyases; Pteridines; Pterins; Spectrophotometry

1984
Combined tetrahydrobiopterin-phenylalanine loading test in the detection of partially defective biopterin synthesis.
    European journal of pediatrics, 1984, Volume: 142, Issue:2

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Biopterins; Child; Child, Preschool; Electroencephalography; Female; Humans; Neopterin; Phenylalanine; Pteridines

1984
Urinary neopterin is elevated in patients with malaria.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1984, Volume: 78, Issue:4

    Topics: Adolescent; Adult; Biopterins; Child; Chromatography, High Pressure Liquid; Female; Humans; Malaria; Male; Middle Aged; Neopterin; Pteridines

1984
Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species.
    Life sciences, 1984, Oct-29, Volume: 35, Issue:18

    Topics: Aminohydrolases; Animals; Biopterins; Cricetinae; Dogs; GTP Cyclohydrolase; Guinea Pigs; Macaca fascicularis; Mice; Neopterin; Pteridines; Rats; Tissue Distribution

1984
Radioimmunoassay for neopterin in body fluids and tissues.
    Analytical biochemistry, 1984, Volume: 141, Issue:2

    Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; Cross Reactions; Humans; Liver; Neopterin; Pteridines; Radioimmunoassay; Rats; Spectrometry, Fluorescence

1984
Urinary neopterin in the diagnosis and follow-up of neoplasia: a biochemical parameter to detect cell-mediated immune response.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1984, Volume: 5, Issue:3-4

    Topics: Adolescent; Adult; Aged; Biopterins; Female; Follow-Up Studies; Genital Neoplasms, Female; Humans; Immunity, Cellular; Leukemia; Lymphoma; Male; Middle Aged; Neoplasms; Neopterin; Pteridines; Urologic Neoplasms

1984
Neopterin as an index of immune response in patients with tuberculosis.
    Lung, 1984, Volume: 162, Issue:6

    Topics: Adolescent; Adult; Aged; Biopterins; Chromatography, High Pressure Liquid; Female; Humans; Immunity, Cellular; Male; Middle Aged; Neopterin; Prognosis; Pteridines; Tuberculosis, Pulmonary

1984
Urinary pteridines on patients suffering from cancer. A comment on the method and results of Rao and associates and of Trehan and associates.
    Cancer, 1984, Apr-01, Volume: 53, Issue:7

    Topics: Biopterins; Charcoal; Chromatography, High Pressure Liquid; Humans; Leukemia, Myeloid, Acute; Neopterin; Pteridines; Pterins; Spectrometry, Fluorescence

1984
Urinary excretion of biopterin and neopterin in psychiatric disorders.
    Psychiatry research, 1984, Volume: 11, Issue:2

    Topics: Adult; Biopterins; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Neopterin; Pteridines; Schizophrenia

1984
[Neopterin, a new biochemical marker for the detection of activated T lymphocytes].
    Wiener klinische Wochenschrift, 1983, Mar-04, Volume: 95, Issue:5

    Topics: Arthritis, Rheumatoid; Biopterins; Dermatitis, Contact; Graft Rejection; Histocytochemistry; Humans; Immunity, Cellular; Lymphocyte Activation; Neoplasms; Neopterin; Pteridines; T-Lymphocytes; Tuberculosis, Pulmonary; Virus Diseases

1983
[Neopterin, a new biochemical marker for clinical assessment of cell-mediated immune response].
    Klinische Wochenschrift, 1984, Feb-01, Volume: 62, Issue:3

    Topics: Adolescent; Adult; Aged; Biopterins; Female; Humans; Immune System Diseases; Immunity, Cellular; In Vitro Techniques; Male; Middle Aged; Neopterin; Pteridines; T-Lymphocytes

1984
Elevated urinary neopterin levels in patients with the acquired immunodeficiency syndrome (AIDS). A preliminary report.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1983, Volume: 364, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Biopterins; Chromatography, High Pressure Liquid; Humans; Lymphoproliferative Disorders; Neopterin; Pteridines; Reference Values

1983
Tetrahydrobiopterin is synthesized by separate pathways from dihydroneopterin triphosphate and from sepiapterin in adrenal medulla preparations.
    Archives of biochemistry and biophysics, 1983, Volume: 227, Issue:1

    Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chemical Phenomena; Chemistry; Guanosine Triphosphate; Methotrexate; Neopterin; Pteridines; Pterins

1983
Dihydrobiopterin biosynthesis deficiency.
    European journal of pediatrics, 1983, Volume: 141, Issue:2

    Topics: Biopterins; Female; Humans; Infant; Infant, Newborn; Metabolism, Inborn Errors; Neopterin; Phenylalanine; Pteridines

1983
Improved diagnosis of classical vs atypical phenylketonuria by liquid chromatography.
    Clinical chemistry, 1984, Volume: 30, Issue:2

    Topics: Biopterins; Chromatography, Liquid; Creatinine; Humans; Infant; Neopterin; Phenylketonurias; Pteridines; Statistics as Topic

1984
Guanosine triphosphate cyclohydrolase activity in rat tissues.
    The Biochemical journal, 1984, Jan-01, Volume: 217, Issue:1

    Topics: Aminohydrolases; Animals; Brain; Chromatography, Gel; Formates; GTP Cyclohydrolase; Kidney; Liver; Male; Models, Chemical; Neopterin; Pteridines; Rats; Rats, Inbred Strains; Tissue Distribution

1984
Urinary neopterin in the diagnosis of acquired immune deficiency syndrome.
    European journal of clinical microbiology, 1984, Volume: 3, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Biopterins; Humans; Male; Neopterin; Pteridines

1984
Current status of biopterin screening.
    The Journal of pediatrics, 1984, Volume: 104, Issue:4

    Topics: Biopterins; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Mass Screening; Neopterin; Phenylalanine; Phenylketonurias; Pteridines

1984
GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia.
    European journal of pediatrics, 1984, Volume: 141, Issue:4

    Topics: Adolescent; Aminohydrolases; Biopterins; Child; Child, Preschool; Dopamine; Female; GTP Cyclohydrolase; Humans; Infant; Liver; Metabolism, Inborn Errors; Muscle Hypotonia; Neopterin; Phenylalanine; Pteridines; Serotonin

1984
Neopterin retards loss of serotonin N-acetyltransferase activity from cultured chick pineal glands.
    Journal of neurochemistry, 1984, Volume: 43, Issue:2

    Topics: Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Biopterins; Cells, Cultured; Chickens; Circadian Rhythm; Darkness; Kinetics; Light; Neopterin; Photolysis; Pineal Gland; Pteridines

1984
Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type.
    Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:7

    Topics: Aged; Alzheimer Disease; Biopterins; Dihydropteridine Reductase; Humans; Kinetics; Neopterin; Pteridines; Temporal Lobe

1984
Pterin metabolism in normal subjects and hyperphenylalaninaemic patients.
    Journal of inherited metabolic disease, 1981, Volume: 4, Issue:2

    Topics: Adult; Alcohol Oxidoreductases; Biopterins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; NADH, NADPH Oxidoreductases; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins; Xanthopterin

1981
Synthesis of biopterin from dihydroneopterin triphosphate by rat tissues.
    Biochimica et biophysica acta, 1983, Apr-20, Volume: 756, Issue:3

    Topics: Animals; Biopterins; Chromatography, High Pressure Liquid; Iodine; Kidney; Liver; Neopterin; Oxidation-Reduction; Pineal Gland; Pteridines; Rats; Rats, Inbred Strains

1983
Guanosine triphosphate cyclohydrolase I assay in human and rat liver using high-performance liquid chromatography of neopterin phosphates and guanine nucleotides.
    Analytical biochemistry, 1983, Feb-01, Volume: 128, Issue:2

    Topics: Aminohydrolases; Animals; Biopterins; Chromatography, High Pressure Liquid; GTP Cyclohydrolase; Guanine Nucleotides; Humans; Liver; Neopterin; Pteridines; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence

1983
Determination of biopterin and other pterins in tissues and body fluids by high-performance liquid chromatography.
    Journal of chromatography, 1983, May-13, Volume: 274

    Topics: Biopterins; Body Fluids; Chromatography, High Pressure Liquid; Humans; Neopterin; Neuroblastoma; Pteridines; Pterins; Xanthopterin

1983
Measurement of urinary neopterin in normal pregnant and non-pregnant women and in women with benign and malignant genital tract neoplasms.
    Archives of gynecology, 1983, Volume: 233, Issue:2

    Topics: Adolescent; Adult; Aged; Biopterins; Female; Genital Neoplasms, Female; Humans; Male; Middle Aged; Neopterin; Postpartum Period; Precancerous Conditions; Pregnancy; Pteridines; Reference Values; Uterine Cervical Neoplasms; Uterine Neoplasms

1983
Significance of urinary neopterine in gynecological oncology: follow-up of patients with ovarian cancer.
    Cancer detection and prevention, 1983, Volume: 6, Issue:1-2

    Topics: Adult; Aged; Biopterins; Female; Follow-Up Studies; Humans; Middle Aged; Neopterin; Ovarian Neoplasms; Pteridines

1983
Isolation and preparation of pterins from biological materials.
    Methods in enzymology, 1980, Volume: 66

    Topics: Animals; Anura; Biopterins; Chromatography, Ion Exchange; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Rana catesbeiana; Skin

1980
Determination of neopterine in human urine by reversed-phase high-performance liquid chromatography.
    Journal of chromatography, 1982, Jan-08, Volume: 227, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Biopterins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Creatinine; Female; Humans; Male; Middle Aged; Neopterin; Pteridines; Reference Values; Sex Factors

1982
Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy.
    Clinical biochemistry, 1982, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Biopterins; Female; Humans; Hypergammaglobulinemia; Leukemia; Lymphoma; Male; Middle Aged; Multiple Myeloma; Neopterin; Pteridines

1982
Urinary neopterine excretion in patient with genital cancer.
    Clinical biochemistry, 1982, Volume: 15, Issue:1

    Topics: Adult; Aged; Biopterins; Female; Genital Neoplasms, Female; Humans; Male; Middle Aged; Neopterin; Pteridines; Reference Values; Sex Factors

1982
Atypical phenylketonuria with defective biopterin metabolism. Monotherapy with tetrahydrobiopterin or sepiapterin, screening and study of biosynthesis in man.
    European journal of pediatrics, 1982, Volume: 138, Issue:2

    Topics: Biopterins; Child, Preschool; Female; Humans; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins; Serotonin

1982
Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin: evidence that peripherally administered tetrahydropterins enter the brain.
    Pediatrics, 1982, Volume: 70, Issue:3

    Topics: Biopterins; Brain; Child; Child, Preschool; Female; Humans; Male; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins

1982
Biosynthesis, nonenzymatic synthesis, and purification of the intermediate in synthesis of sepiapterin in Drosophila.
    Biochemistry, 1982, Aug-03, Volume: 21, Issue:16

    Topics: Drosophila; Hydrogen-Ion Concentration; Magnesium; NADP; Neopterin; Pteridines; Pterins

1982
Developmental aspects of pteridine metabolism and relationships with phenylalanine metabolism.
    Clinica chimica acta; international journal of clinical chemistry, 1981, Oct-26, Volume: 116, Issue:2

    Topics: Adolescent; Adult; Aging; Amniotic Fluid; Animals; Biopterins; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Neopterin; Phenylalanine; Phenylketonurias; Pregnancy; Pteridines; Rats; Rats, Inbred Strains

1981
Urinary neopterine as marker for haematological neoplasias.
    Clinica chimica acta; international journal of clinical chemistry, 1981, Dec-24, Volume: 117, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Biopterins; Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Female; Humans; Leukemia; Lymphoma; Male; Middle Aged; Neoplasm Staging; Neopterin; Pteridines; Reference Values

1981
Altered urinary excretion of pteridines in neoplastic disease. Determination of biopterin, neopterin, xanthopterin, and pterin.
    Clinica chimica acta; international journal of clinical chemistry, 1980, Aug-04, Volume: 105, Issue:2

    Topics: Biopterins; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Creatinine; Humans; Lymphoma; Neoplasms; Neopterin; Pteridines; Pterins; Xanthopterin

1980
Neopterin and biopterin levels in patients with atypical forms of phenylketonuria.
    Journal of neurochemistry, 1980, Volume: 35, Issue:4

    Topics: Amino Acid Metabolism, Inborn Errors; Biopterins; Chromatography, High Pressure Liquid; Humans; Liver; Neopterin; Phenylalanine; Phenylketonurias; Pteridines

1980
7,8 Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant.
    Free radical research, 1995, Volume: 23, Issue:2

    Topics: Adult; Amidines; Antioxidants; Biopterins; Copper; Dose-Response Relationship, Drug; Female; Humans; Linoleic Acid; Linoleic Acids; Lipoproteins, LDL; Macrophages; Male; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Vitamin E

1995
Atomic structure of GTP cyclohydrolase I.
    Structure (London, England : 1993), 1995, May-15, Volume: 3, Issue:5

    Topics: Alcohol Oxidoreductases; Bacterial Proteins; Binding Sites; Biopterins; Catalysis; Crystallography, X-Ray; Escherichia coli; GTP Cyclohydrolase; Guanosine Triphosphate; Models, Molecular; Neopterin; Phosphorus-Oxygen Lyases; Protein Conformation; Pteridines

1995
Detection of bacterial pyrogens on the basis of their effects on gamma interferon-mediated formation of neopterin or nitrite in cultured monocyte cell lines.
    Clinical and diagnostic laboratory immunology, 1995, Volume: 2, Issue:3

    Topics: Animals; Bacterial Proteins; Biopterins; Cell Line; Endotoxins; Humans; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Monocytes; Neopterin; Nitrites; Pteridines; Pyrogens; Salmonella typhimurium; Tumor Cells, Cultured

1995
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.
    The Journal of biological chemistry, 1993, Jan-25, Volume: 268, Issue:3

    Topics: Amino Acid Oxidoreductases; Biopterins; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypoxanthines; Interferon-gamma; Lipopolysaccharides; Neopterin; Nitric Oxide; Nitric Oxide Synthase; Pteridines; Pterins; Tumor Necrosis Factor-alpha; Umbilical Veins

1993
Effect of neopterin and 7,8-dihydroneopterin on tumor necrosis factor-alpha induced programmed cell death.
    FEBS letters, 1995, May-08, Volume: 364, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; Biopterins; Cell Line; Drug Synergism; Hydrogen Peroxide; Neopterin; Oxidative Stress; Pteridines; Reactive Oxygen Species; Superoxide Dismutase; Tumor Necrosis Factor-alpha

1995
Enzymic characterization of Bacillus subtilis GTP cyclohydrolase I. Evidence for a chemical dephosphorylation of dihydroneopterin triphosphate.
    The Biochemical journal, 1995, Mar-01, Volume: 306 ( Pt 2)

    Topics: Bacillus subtilis; Base Sequence; Binding, Competitive; Calcium; Folic Acid; Gene Expression; GTP Cyclohydrolase; Guanosine Triphosphate; Kinetics; Magnesium; Molecular Sequence Data; Neopterin; Operon; Phosphorylation; Plasmids; Potassium; Promoter Regions, Genetic; Pteridines; Recombinant Proteins; Uridine Triphosphate

1995
Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression.
    FEBS letters, 1994, Sep-19, Volume: 352, Issue:1

    Topics: 3T3 Cells; Animals; Base Sequence; Biopterins; Chloramphenicol O-Acetyltransferase; Cyclic GMP; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Mice; Molecular Sequence Data; Neopterin; Phorbol 12,13-Dibutyrate; Promoter Regions, Genetic; Protein Kinase C; Pteridines; Transcription, Genetic; Transcriptional Activation

1994
Neopterin modulates toxicity mediated by reactive oxygen and chloride species.
    FEBS letters, 1993, Apr-19, Volume: 321, Issue:1

    Topics: Animals; Biopterins; Blood Bactericidal Activity; Chloramines; Escherichia coli; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hypochlorous Acid; In Vitro Techniques; Luminescent Measurements; Macrophages; Neopterin; Pteridines

1993
Effect of pteridine derivatives on intracellular calcium concentration in human monocytic cells.
    FEBS letters, 1993, Mar-08, Volume: 318, Issue:3

    Topics: Biopterins; Calcium; Cell Line; Egtazic Acid; Humans; Lanthanum; Monocytes; Neopterin; Pteridines

1993
Induction of inducible nitric oxide synthase expression by neopterin in vascular smooth muscle cells.
    FEBS letters, 1995, Dec-27, Volume: 377, Issue:3

    Topics: Animals; Antioxidants; Aorta; Base Sequence; Biopterins; Enzyme Induction; Interferon-gamma; Molecular Sequence Data; Muscle, Smooth, Vascular; Neopterin; Nitric Oxide Synthase; Nitrites; Pteridines; Rats; Rats, Inbred WKY; RNA, Messenger

1995
Oxidative stress and apoptosis in HIV infection.
    Science (New York, N.Y.), 1996, Feb-02, Volume: 271, Issue:5249

    Topics: Apoptosis; Biopterins; CD4-Positive T-Lymphocytes; HIV Infections; HIV-1; Humans; Neopterin; Oxidative Stress; Pteridines; Reactive Oxygen Species

1996
Effects of neopterin-derivatives on H2O2-induced luminol chemiluminescence: mechanistic aspects.
    Free radical biology & medicine, 1996, Volume: 21, Issue:4

    Topics: Biopterins; Chromatography, High Pressure Liquid; Edetic Acid; Ferric Compounds; Free Radical Scavengers; Histidine; Humans; Hydrogen Peroxide; Interferon-gamma; Iron Chelating Agents; Kinetics; Luminescent Measurements; Luminol; Macrophages; Monocytes; Neopterin; Oxygen; Pteridines; Singlet Oxygen

1996
Role of 7,8-dihydroneopterin in T-cell apoptosis and HTLV-1 transcription in vitro.
    Oncogene, 1996, Nov-21, Volume: 13, Issue:10

    Topics: Antioxidants; Apoptosis; Gene Products, tax; Human T-lymphotropic virus 1; Humans; Hydrogen Peroxide; Neopterin; Oxidation-Reduction; Pteridines; Repetitive Sequences, Nucleic Acid; T-Lymphocytes; Transfection; Tumor Cells, Cultured

1996
Neopterin and 7,8-dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2.
    FEBS letters, 1996, Nov-18, Volume: 397, Issue:2-3

    Topics: Animals; Apoptosis; Biopterins; Cell Line; Epithelial Cells; Epithelium; Female; Gene Expression; Interferon-gamma; Neopterin; Nitrates; Nitric Oxide Synthase; Nitrites; Pteridines; Pulmonary Alveoli; Rats; Rats, Inbred Lew; RNA, Messenger; Tumor Necrosis Factor-alpha

1996
Dihydroneopterin triphosphate epimerase of Escherichia coli: purification, genetic cloning, and expression.
    Journal of bacteriology, 1997, Volume: 179, Issue:3

    Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cloning, Molecular; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Molecular Sequence Data; Neopterin; Pteridines; Racemases and Epimerases; Restriction Mapping; Sequence Analysis, DNA; Sequence Homology, Amino Acid

1997
trans-Activation of the HIV type 1 promoter by 7,8-dihydroneopterin in vitro.
    AIDS research and human retroviruses, 1997, Jan-20, Volume: 13, Issue:2

    Topics: Biopterins; Chloramphenicol O-Acetyltransferase; Gene Expression Regulation, Viral; HIV Core Protein p24; HIV Seropositivity; HIV-1; Humans; Jurkat Cells; Neopterin; NF-kappa B; Promoter Regions, Genetic; Pteridines; Recombinant Fusion Proteins; Transcription Factor AP-1; Transcriptional Activation; Tumor Necrosis Factor-alpha

1997
7,8-Dihydroneopterin upregulates interferon-gamma promoter in T cells.
    Immunobiology, 1996, Volume: 196, Issue:4

    Topics: Antioxidants; Free Radicals; Gene Expression Regulation; Humans; Interferon-gamma; Jurkat Cells; Neopterin; Promoter Regions, Genetic; Pteridines; Superoxides; T-Lymphocytes; Up-Regulation

1996
Pterin-6-aldehyde, an inhibitor of xanthine oxidase, has superoxide anion radical scavenging activity.
    Biochemical and biophysical research communications, 1997, Apr-17, Volume: 233, Issue:2

    Topics: Biopterins; Chromatography, High Pressure Liquid; Free Radical Scavengers; Free Radicals; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Neopterin; Pteridines; Pterins; Superoxides; Xanthine Oxidase

1997
Neopterin derivatives to activate NF-kappa B.
    Free radical biology & medicine, 1997, Volume: 23, Issue:1

    Topics: Biopterins; Humans; Macrophage Activation; Macrophages; Neopterin; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Pteridines; Reactive Oxygen Species

1997
Spin trapping study of antioxidant properties of neopterin and 7,8-dihydroneopterin.
    Biochemical and biophysical research communications, 1997, May-29, Volume: 234, Issue:3

    Topics: Antioxidants; Biopterins; Electron Spin Resonance Spectroscopy; Kinetics; Neopterin; Oxidation-Reduction; Peroxides; Pteridines; Spin Labels; Superoxides

1997
D-erythro-neopterin biosynthesis in the methanogenic archaea Methanococcus thermophila and Methanobacterium thermoautotrophicum deltaH.
    Journal of bacteriology, 1997, Volume: 179, Issue:16

    Topics: Biopterins; Chromatography, Thin Layer; GTP Cyclohydrolase; Guanosine Triphosphate; Methanobacterium; Methanococcus; Neopterin; Pteridines

1997
Neopterin derivatives modulate the nitration of tyrosine by peroxynitrite.
    Biochemical and biophysical research communications, 1998, Jul-20, Volume: 248, Issue:2

    Topics: Hydrogen-Ion Concentration; Neopterin; Nitrates; Nitro Compounds; Pteridines; Pterins; Spectrophotometry; Tyrosine

1998
Simultaneous determination of pteridines in multicomponent mixtures using derivative spectrophotometry and partial least-squares calibration.
    Journal of pharmaceutical and biomedical analysis, 1998, Volume: 17, Issue:8

    Topics: Drug Combinations; Equipment Design; Least-Squares Analysis; Molecular Structure; Neopterin; Pteridines; Pterins; Spectrophotometry; Xanthopterin

1998
7,8-Dihydroneopterin-induced apoptosis in Jurkat T lymphocytes: a comparison with anti-Fas- and hydrogen peroxide-mediated cell death.
    Biochemical pharmacology, 1998, Nov-01, Volume: 56, Issue:9

    Topics: Antibodies; Apoptosis; fas Receptor; Humans; Hydrogen Peroxide; Jurkat Cells; Neopterin; Phosphorylation; Pteridines; Tyrosine

1998
Pteridines as inhibitors of xanthine oxidase: structural requirements.
    Biochimica et biophysica acta, 1999, Mar-19, Volume: 1430, Issue:2

    Topics: Dose-Response Relationship, Drug; Isomerism; Kinetics; Neopterin; Pteridines; Structure-Activity Relationship; Xanthine Oxidase

1999
Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate.
    The Journal of biological chemistry, 1999, Jun-11, Volume: 274, Issue:24

    Topics: Catalytic Domain; Escherichia coli; GTP Cyclohydrolase; Guanosine Triphosphate; Histidine; Models, Chemical; Mutation; Neopterin; Nuclear Magnetic Resonance, Biomolecular; Pteridines; Pyrimidine Nucleotides

1999
Effects of neopterin and 7,8-dihydroneopterin on hypoxia-induced renal erythropoietin production.
    European journal of haematology, 1999, Volume: 62, Issue:5

    Topics: Animals; Antioxidants; Cell Hypoxia; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Humans; Kidney; Male; Neopterin; Polymerase Chain Reaction; Pteridines; Rats; Rats, Sprague-Dawley; RNA, Messenger

1999
Formation of oxygen radicals in solutions of 7,8-dihydroneopterin.
    Biochemical and biophysical research communications, 1999, Oct-14, Volume: 264, Issue:1

    Topics: Catalase; Chromatography, High Pressure Liquid; Edetic Acid; Hydroxyl Radical; Hydroxylation; Iron; Neopterin; Oxygen; Pteridines; Superoxide Dismutase; Superoxides

1999
Neopterin derivatives modulate toxicity of reactive species on Escherichia coli.
    Free radical research, 1999, Volume: 31, Issue:5

    Topics: Anti-Bacterial Agents; Chloramines; Disinfectants; Drug Interactions; Escherichia coli; Formaldehyde; Humans; Hydrogen Peroxide; Neopterin; Pteridines; Reactive Oxygen Species; Sodium Hypochlorite; Sodium Nitrite; Tosyl Compounds

1999
Inhibition of haemolysis by the macrophage synthesized antioxidant, 7,8-dihydroneopterin.
    Redox report : communications in free radical research, 2000, Volume: 5, Issue:2-3

    Topics: Animals; Antioxidants; Erythrocyte Membrane; Hemolysis; In Vitro Techniques; Kinetics; Macrophages; Neopterin; Pteridines; Swine; Tyrosine

2000
Oxidation of 7,8-dihydroneopterin by hypochlorous acid yields neopterin.
    Biochemical and biophysical research communications, 2000, Aug-28, Volume: 275, Issue:2

    Topics: Chromatography, High Pressure Liquid; Hypochlorous Acid; Neopterin; Oxidation-Reduction; Pteridines; Radioimmunoassay

2000
Ring opening is not rate-limiting in the GTP cyclohydrolase I reaction.
    The Journal of biological chemistry, 2001, Jan-26, Volume: 276, Issue:4

    Topics: Aldose-Ketose Isomerases; Escherichia coli; Flow Injection Analysis; Formates; GTP Cyclohydrolase; Guanosine Triphosphate; Models, Chemical; Neopterin; Pteridines; Pyrimidine Nucleotides

2001
Inflammation marker 7,8-dihydroneopterin induces apoptosis of neurons and glial cells: a potential contribution to neurodegenerative processes.
    Immunobiology, 2000, Volume: 202, Issue:5

    Topics: Acid Phosphatase; Antioxidants; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Neopterin; Neuroglia; Neurons; Pteridines

2000
Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin.
    Free radical research, 2001, Volume: 34, Issue:2

    Topics: Amidines; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Erythrocyte Membrane; Erythrocytes; Hemolysis; Humans; Hydrogen Peroxide; Hypochlorous Acid; Interferon-gamma; Lipid Peroxidation; Macrophages; Neopterin; Oxidation-Reduction; Pteridines; Swine; Tyrosine

2001
Induction of apoptosis by 7,8-dihydroneopterin: involvement of radical formation.
    Immunobiology, 2001, Volume: 203, Issue:4

    Topics: Apoptosis; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Fas Ligand Protein; Humans; Hydroxyl Radical; Interferon-gamma; Jurkat Cells; Membrane Glycoproteins; Neopterin; Pteridines; Reactive Oxygen Species; Spin Labels; T-Lymphocytes

2001
Inhibition of protein oxidation by the macrophage-synthesised antioxidant 7,8-dihydroneopterin.
    Redox report : communications in free radical research, 2001, Volume: 6, Issue:3

    Topics: Amidines; Animals; Antioxidants; Blood; Cattle; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Inflammation; Macrophages; Neopterin; Oxidants; Oxidation-Reduction; Peroxides; Proteins; Pteridines; Serum Albumin, Bovine

2001
Protection of U937 cells from free radical damage by the macrophage synthesized antioxidant 7,8-dihydroneopterin.
    Free radical research, 2001, Volume: 35, Issue:3

    Topics: Amidines; Antioxidants; Cell Survival; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Free Radicals; Humans; Hydrogen Peroxide; Hypochlorous Acid; Iron; Lipid Peroxidation; Macrophages; Neopterin; Pteridines; Thiobarbituric Acid Reactive Substances; U937 Cells

2001
Influence of cytokines tumor necrosis factor-alpha and interferon-gamma on signaling cascades associated with apoptosis in rat PC12 cells.
    Neuroscience letters, 2001, Dec-28, Volume: 316, Issue:3

    Topics: Animals; Antioxidants; Apoptosis; Central Nervous System; Immunity, Cellular; Interferon-gamma; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Neopterin; Neurodegenerative Diseases; Neurons; Oxidative Stress; PC12 Cells; Pteridines; Rats; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2001
Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate.
    Journal of molecular biology, 2002, Feb-22, Volume: 316, Issue:3

    Topics: Catalysis; Escherichia coli; Formates; GTP Cyclohydrolase; Guanosine Triphosphate; Hydrolysis; Kinetics; Mutation; Neopterin; Pteridines; Pyrimidine Nucleotides; Schiff Bases; Spectrophotometry, Ultraviolet; Stereoisomerism

2002
7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway.
    European journal of cell biology, 2002, Volume: 81, Issue:4

    Topics: Antioxidants; Apoptosis; Enzyme Activation; Enzyme Inhibitors; Humans; Jurkat Cells; Mitogen-Activated Protein Kinases; Neopterin; Proto-Oncogene Proteins c-bcl-2; Pteridines; Serpins; Signal Transduction; Staurosporine; Viral Proteins

2002
Plasma pteridine concentrations in patients with chronic renal failure.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17, Issue:6

    Topics: Biomarkers; Biopterins; Humans; Kidney Failure, Chronic; Neopterin; Pteridines; Reference Values; Regression Analysis; Renal Dialysis

2002
Generation of carbon monoxide and iron from hemeproteins in the presence of 7,8-dihydroneopterin.
    Biochimica et biophysica acta, 2002, Jun-06, Volume: 1571, Issue:2

    Topics: Animals; Carbon Monoxide; Ferrous Compounds; Hemeproteins; Horses; Humans; Iron; Kinetics; Neopterin; Pteridines; Spectrum Analysis

2002
Neopterin and 7,8-dihydroneopterin interfere with low density lipoprotein oxidation mediated by peroxynitrite and/or copper.
    Free radical research, 2002, Volume: 36, Issue:5

    Topics: Copper; Drug Interactions; Electrophoretic Mobility Shift Assay; Humans; Lipoproteins, LDL; Macrophages; Neopterin; Oxidation-Reduction; Peroxynitrous Acid; Pteridines

2002
Protein and thiol oxidation in cells exposed to peroxyl radicals is inhibited by the macrophage synthesised pterin 7,8-dihydroneopterin.
    Biochimica et biophysica acta, 2002, Aug-19, Volume: 1591, Issue:1-3

    Topics: Amidines; Antioxidants; Cell Survival; Humans; Macrophages; Neopterin; Oxidants; Oxidation-Reduction; Peroxides; Pteridines; Sulfhydryl Compounds; U937 Cells

2002
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I.
    Journal of molecular biology, 2003, Feb-14, Volume: 326, Issue:2

    Topics: Amino Acid Sequence; Animals; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Escherichia coli; Formamides; Formates; GTP Cyclohydrolase; Guanosine Triphosphate; Hydrogen Bonding; Hydrolysis; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Neopterin; Protein Conformation; Pteridines; Stereoisomerism; Zinc

2003
Induction of apoptosis in human blood T cells by 7,8-dihydroneopterin: the difference between healthy controls and patients with systemic lupus erythematosus.
    Clinical immunology (Orlando, Fla.), 2003, Volume: 107, Issue:3

    Topics: Adult; Annexin A5; Antioxidants; Apoptosis; Cells, Cultured; Concanavalin A; Cytokines; Dose-Response Relationship, Drug; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Neopterin; Phytohemagglutinins; Pteridines; T-Lymphocytes; Time Factors

2003
A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plants.
    The Journal of biological chemistry, 2005, Feb-18, Volume: 280, Issue:7

    Topics: Amino Acid Sequence; Diphosphates; Escherichia coli; Folic Acid; Kinetics; Lactococcus lactis; Magnesium; Manganese; Molecular Sequence Data; Neopterin; Nudix Hydrolases; Open Reading Frames; Phylogeny; Plants; Pteridines; Pyrophosphatases; Substrate Specificity

2005
Evaluation of pteridine metabolism in battery workers chronically exposed to lead.
    Human & experimental toxicology, 2006, Volume: 25, Issue:7

    Topics: Adult; Air Pollutants, Occupational; Aminolevulinic Acid; Biomarkers; Biopterins; Creatinine; Dihydropteridine Reductase; Environmental Monitoring; Evaluation Studies as Topic; Humans; Lead; Male; Neopterin; Neuromuscular Junction Diseases; Occupational Exposure; Pteridines

2006
Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase.
    Biochemistry, 2009, Mar-24, Volume: 48, Issue:11

    Topics: Carbon-Oxygen Lyases; Escherichia coli; Escherichia coli Proteins; Neopterin; Pteridines

2009
Differences in pteridine urinary levels in patients with malignant and benign ovarian tumors in comparison with healthy individuals.
    Journal of photochemistry and photobiology. B, Biology, 2015, Volume: 153

    Topics: Adult; Aged; Biopterins; Chromatography, High Pressure Liquid; Female; Humans; Manganese Compounds; Middle Aged; Neopterin; Ovarian Neoplasms; Oxides; Pteridines

2015
Urinary neopterin and biopterin indicate that inflammation has a role in autism spectrum disorder.
    Metabolic brain disease, 2023, Volume: 38, Issue:8

    Topics: Autism Spectrum Disorder; Biomarkers; Biopterins; Cross-Sectional Studies; Humans; Inflammation; Neopterin; Prospective Studies; Pteridines

2023