pteridines has been researched along with methotrexate in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (65.28) | 18.7374 |
| 1990's | 13 (18.06) | 18.2507 |
| 2000's | 8 (11.11) | 29.6817 |
| 2010's | 3 (4.17) | 24.3611 |
| 2020's | 1 (1.39) | 2.80 |
| Authors | Studies |
|---|---|
| Blakley, RL; Cocco, L; London, RE; Matwiyoff, NA; Walker, TE | 1 |
| Cotton, RG | 1 |
| Calvert, AH; Jarman, M | 1 |
| Azarnoff, DL; Hignite, CE; Shen, DD | 1 |
| Montgomery, JA; Piper, JR | 1 |
| Blair, JA; Leeming, RJ; Melikian, V; O'Gorman, DJ | 1 |
| Gasco, MR | 1 |
| Chaydovsky, M | 1 |
| Gross, SS; Levi, R | 1 |
| David, CL; Farnum, MF; Howell, EE; Kraut, J; Oatley, SJ; Villafranca, JE | 1 |
| Blais, JC; Dhondt, JL; Hayte, JM; Klein, R; Millot, F; Pfleiderer, W | 1 |
| Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G | 1 |
| Hannuksela, M; Lahti, A; Puurunen, J | 1 |
| Chessells, JM; Curzon, G; Hyland, K; Leeming, RJ; Pinkerton, CR; Sarna, G; Smith, I | 1 |
| Heath, TD; Ng, KY | 1 |
| Bowers, SW; Duch, DS | 1 |
| Benkovic, SJ; Taira, K | 1 |
| Morrison, JF; Stone, SR | 1 |
| Heath, TD; Lopez, NG; Montgomery, JA; Papahadjopoulos, D; Piper, JR; Stern, WH | 1 |
| Aubailly, M; Chahidi, C; Giraud, M; Santus, R; Valla, A | 1 |
| Webber, S; Whiteley, JM | 1 |
| Bertino, JR; DeConti, RC; Mosher, MB | 1 |
| Sirotnak, FM | 1 |
| Chaykovsky, M; Chen, KK; Gaumont, Y; Kisliuk, RL; Modest, EJ; Papathanasopoulos, N; Rosowsky, A | 1 |
| Buehring, KU; Shin, YS; Stokstad, EL | 1 |
| Burchall, JJ; Hitchings, GH | 1 |
| Gutteridge, WE; Jaffe, JJ; McCormack, JJ | 1 |
| Brown, VH; Colwell, WT; DeGraw, JI; Morrison, NE | 1 |
| Valerino, DM | 1 |
| Hermanová, E; Pristoupilová, K; Slavík, K | 1 |
| Goodman, L; Lee, WW; Martinez, AP | 1 |
| Algeri, S; Ponzio, F; Turner, AJ | 1 |
| Roberts, PJ | 1 |
| Crusberg, TC; Kisliuk, RL; Leary, R | 1 |
| Johns, DG; Oliverio, VT; Valerino, DM; Zaharko, DS | 1 |
| Bertino, JR; Iannotti, AT; Johns, DG; Perkins, JP | 1 |
| D'Angelo, GL; McQueen, CA; Musacchio, JM | 1 |
| Lucas, MB; Pittillo, RF | 1 |
| Elliott, RD; Montgomery, JA; Temple, C | 2 |
| Botterill, V; Hall, TC; Kessel, D | 1 |
| Goldman, P; Levy, CC | 1 |
| Adamson, RH; Loo, TL | 1 |
| Chao, JY; Duch, DS; Edelstein, MP; Lee, CL; Nichol, CA | 1 |
| Fleary, M; Lewis, AS; McCalla, C; Murphy, L; Purcell, S | 1 |
| Nichol, CA; Smith, GK | 1 |
| Culvenor, AJ; Levine, RA; Lovenberg, W; Miller, LP | 1 |
| Duch, DS; Edelstein, MP; Lee, CL; Nichol, CA | 1 |
| Carey, PR; King, RW; Ozaki, Y | 1 |
| Chaykovsky, M; Martinelli, JE | 1 |
| Amoah-Apraku, B; Guzman, NJ; Ingelfinger, JR; Tang, SS | 1 |
| Bello, AR; Beverley, SM; Freedman, D; Hardy, L; Nare, B | 1 |
| Dhondt, JL; Farriaux, JP; Hayte, JM; Mazingue, F; Millot, F | 1 |
| Beverley, SM; Hardy, LW; Nare, B | 1 |
| Beverley, S; Hardy, LW; Luba, J; Nare, B | 1 |
| Beverley, SM; Hardy, LW; Matthews, W; Nare, B | 1 |
| Díaz-Cazorla, M; Jiménez, W; Lamas, S; Pérez-Sala, D; Ros, J | 1 |
| Haimeur, A; Kündig, C; Légaré, D; Ouellette, M; Papadopoulou, B | 1 |
| Kabaki, M; Kakinuma, M; Kawada, K; Kawata, K; Kokuryo, Y; Kugimiya, A; Matsumoto, M; Nakatani, T; Ohtani, M; Suzuki, R | 1 |
| Chenon, K; De Lorenzi, E; Hall, AJ; Quaglia, M; Sellergren, B | 1 |
| Aoshima, M; Hirakawa, K; Hiraku, Y; Kawanishi, S | 1 |
| Dastychová, E | 1 |
| COLLIER, HO; GRIMSHAW, JJ; HUSKINSON, PL | 1 |
| KENNEDY, EP; LINDBERG, M; TIETZ, A | 1 |
| Durán Merás, I; Espinosa Mansilla, A; Rodríguez Gómez, MJ | 1 |
| Noszál, B; Szakács, Z | 1 |
| Ishih, A; Kino, H; Muregi, FW | 1 |
| Barbosa, AF; Bello, AR; Este, MG; Pirmez, C; Sampaio, MC; Traub-Csekö, YM | 1 |
| Aroulmoji, V; Ayyappan, S; Murano, E; Sebastian, S; Sundaraganesan, N | 1 |
| Bhakta, S; Degani, MS; Kamil, TK; Lele, AC; Mishra, DA | 1 |
| Carmona-Martínez, V; García-Peñarrubia, P; Guirado, A; Martínez-Esparza, M; Ruiz-Alcaraz, AJ; Vera, M | 1 |
| Antypenko, OM; Groma, NV; Kazunin, MS; Kinichenko, AO; Kovalenko, SI; Nosulenko, IS; Shvets, VM; Voskoboinik, OY | 1 |
4 review(s) available for pteridines and methotrexate
| Article | Year |
|---|---|
Inhibition of folate biosynthesis and function as a basis for chemotherapy.
Topics: Aminobenzoates; Animals; Binding Sites; Biological Transport; Drug Resistance, Microbial; Drug Synergism; Escherichia coli; Folic Acid; Folic Acid Antagonists; Glutamates; Guinea Pigs; Humans; Lactobacillus; Leucovorin; Methotrexate; NAD; NADP; Pteridines; Pyrimidines; Rabbits; Rats; Sulfonamides | 1965 |
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leishmania; Leishmaniasis; Methotrexate; Oxidoreductases; Pteridines | 1997 |
Repositioning of DHFR Inhibitors.
Topics: Anti-Infective Agents; Antineoplastic Agents; Drug Repositioning; Folic Acid Antagonists; Humans; Methotrexate; Pteridines; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2016 |
Therapeutic potential of pteridine derivatives: A comprehensive review.
Topics: Aminopterin; Animals; Anti-Infective Agents; Antidepressive Agents; Antihypertensive Agents; Antineoplastic Agents; Antiparasitic Agents; Clinical Trials as Topic; Humans; Inhibitory Concentration 50; Methotrexate; Pteridines; Triamterene | 2019 |
1 trial(s) available for pteridines and methotrexate
| Article | Year |
|---|---|
Biopterin and neurotransmitter amine metabolism in children with acute lymphoblastic leukemia receiving methotrexate therapy.
Topics: Adolescent; Biopterins; Child; Child, Preschool; Clinical Trials as Topic; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Neurotransmitter Agents; Pteridines | 1986 |
67 other study(ies) available for pteridines and methotrexate
| Article | Year |
|---|---|
Nuclear magnetic resonance studies on bacterial dihydrofolate reductase containing [methyl-13C]methionine.
Topics: Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Methionine; Methotrexate; NADP; Nucleotides; Pteridines; Streptococcus; Temperature; Tetrahydrofolate Dehydrogenase | 1978 |
Additional rescue from methotrexate toxicity?
Topics: Biopterins; Brain; Child, Preschool; Dihydropteridine Reductase; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Infant; Methotrexate; Phenylketonurias; Pteridines | 1978 |
Radiolabelled methotrexate: a warning.
Topics: Animals; Haplorhini; Humans; Hydroxylation; Isotope Labeling; Kidney; Macaca mulatta; Methotrexate; Pteridines; Tritium | 1979 |
Separation and identification of impurities in parenteral methotrexate dosage forms.
Topics: Chromatography, High Pressure Liquid; Drug Contamination; Humans; Injections, Intravenous; Methotrexate; Pteridines | 1978 |
Preparation of 6-(bromomethyl)-2,4-pteridinediamine hydrobromide and its use in improved syntheses of methotrexate and related compounds.
Topics: Bromine; Diamines; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methods; Methotrexate; Methylation; Pteridines | 1977 |
Biopterin derivatives in human body fluids and tissues.
Topics: Adolescent; Adult; Biological Assay; Biopterins; Body Fluids; Brain Chemistry; Chemical Phenomena; Chemistry; Child; Chromatography, DEAE-Cellulose; Culture Media; Eukaryota; Female; Folic Acid; Humans; Leukemia; Liver; Male; Methotrexate; Middle Aged; Milk, Human; Psoriasis; Pteridines | 1976 |
[Charge-transfer complexes of hematoporphyrin with pteridine derivatives].
Topics: Buffers; Folic Acid; Hematoporphyrins; Leucovorin; Methotrexate; Pteridines; Solutions | 1976 |
Direct n8-alkylation of 2,4-dihydropteridines;Preparation of 7,8-dihydro-8-methylmethotrexate.
Topics: Alkylation; Diamines; Hydroxylation; Methods; Methotrexate; Pteridines | 1975 |
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Biopterins; Cells, Cultured; Cytosol; Hypoxanthines; Interferon-gamma; Kinetics; Lipopolysaccharides; Male; Methotrexate; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen Consumption; Pteridines; Pterins; Rats; Rats, Inbred F344; Recombinant Proteins | 1992 |
Structure and function of alternative proton-relay mutants of dihydrofolate reductase.
Topics: Asparagine; Binding Sites; Crystallography; Escherichia coli; Glutamates; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Protons; Pteridines; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1992 |
2,4-diamino-7-hydroxy-pteridines, a new class of catabolites of methotrexate.
Topics: Adolescent; Adult; Animals; Biotransformation; Child; Child, Preschool; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hodgkin Disease; Humans; Liver; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines; Rabbits; Rats | 1991 |
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.
Topics: Animals; Biopterins; Cells, Cultured; Cytokines; Fibroblasts; Interferon-gamma; Interleukin-1; Kinetics; Methotrexate; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Pteridines; Pterins; Recombinant Proteins; Skin; Sugar Acids; Tumor Necrosis Factor-alpha | 1990 |
Occupational contact allergy to 2,4-diamino-6-chloromethylpteridine hydrochloride: an intermediate product in methotrexate synthesis.
Topics: Adult; Dermatitis, Contact; Dermatitis, Occupational; Drug Industry; Facial Dermatoses; Humans; Male; Methotrexate; Patch Tests; Pteridines | 1990 |
Liposome-dependent delivery of pteridine antifolates: a two-compartment growth inhibition assay for evaluating drug leakage and metabolism.
Topics: Animals; Biological Assay; Cell Division; Cells, Cultured; Cholesterol; Folic Acid Antagonists; Liposomes; Methotrexate; Permeability; Phosphatidylglycerols; Pteridines; Structure-Activity Relationship | 1989 |
In vivo measurement of dihydrofolate reductase and its inhibition by antifolates.
Topics: Animals; Biopterins; Brain; Folic Acid Antagonists; Injections, Intraventricular; Liver; Male; Methotrexate; Mice; Pteridines; Pterins; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase | 1988 |
Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase.
Topics: Binding Sites; Escherichia coli; Kinetics; Mathematics; Methotrexate; Mutation; Protein Binding; Pteridines; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1988 |
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.
Topics: Animals; Binding, Competitive; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver; Methotrexate; NADP; Pteridines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1986 |
Liposome-mediated delivery of pteridine antifolates to cells in vitro: potency of methotrexate, and its alpha and gamma substituents.
Topics: Cell Line; Liposomes; Methotrexate; Phosphatidylethanolamines; Pteridines; Structure-Activity Relationship; Time Factors | 1986 |
2,4-Diamino-6-pteridinecarboxaldehyde and an azobenzene derivative are produced by UV photodegradation of methotrexate.
Topics: Methotrexate; Photolysis; Pteridines; Ultraviolet Rays | 1986 |
Comparative activity of rat liver dihydrofolate reductase with 7,8-dihydrofolate and other 7,8-dihydropteridines.
Topics: Animals; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Kinetics; Liver; Methotrexate; Osmolar Concentration; Pteridines; Rats; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Urea | 1985 |
Chemotherapy of cancer of the head and neck.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Catheterization; Cyclophosphamide; Glutamates; Head and Neck Neoplasms; Humans; Hydroxyurea; Infusions, Parenteral; Injections, Intravenous; Leucovorin; Methotrexate; Mouth Neoplasms; Pteridines; Remission, Spontaneous | 1973 |
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1973 |
Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.
Topics: Animals; Antimalarials; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Liver; Malaria; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Plasmodium berghei; Pteridines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1974 |
The metabolism of methotrexate in Lactobacillus casei and rat liver and the influence of methotrexate on metabolism of folic acid.
Topics: Animals; Benzoates; Biological Assay; Carboxypeptidases; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enterococcus faecalis; Folic Acid; Glutamates; Kidney; Lacticaseibacillus casei; Liver; Male; Methotrexate; Oxidation-Reduction; Pteridines; Rats; Swine; Tetrahydrofolates; Tritium | 1974 |
Presence and properties of dihydrofolate reductases within the genus Crithidia.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Methotrexate; NADP; Pteridines; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Trypanosoma | 1969 |
Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase.
Topics: Aminopterin; Folic Acid Antagonists; Kinetics; Leprosy; Methotrexate; Mycobacterium leprae; Protein Binding; Pteridines; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1974 |
Studies of the metabolism of methotrexate. II. Isolation and identification of several unconjugated aminopteridines as metabolites in the rat.
Topics: Administration, Oral; Aniline Compounds; Animals; Benzoates; Chromatography, DEAE-Cellulose; Chromatography, Paper; Feces; Male; Methotrexate; Mice; Pteridines; Rats; Spectrophotometry, Ultraviolet; Tritium | 1972 |
Studies on the mechanism of antifolate induced inhibition on HeLa cell growth.
Topics: Aminopterin; Carbon Isotopes; Folic Acid Antagonists; Glucose; Glutamates; Growth; HeLa Cells; Methotrexate; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidine; Time Factors | 1973 |
Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid.
Topics: Animals; Chlorine; Folic Acid Antagonists; Glutamates; Humans; Leukemia; Leukemia L1210; Methotrexate; Mice; Pteridines | 1974 |
Dihydropteridine reductase in rat brain: regional distribution and the effect of catecholamine-depleting drugs.
Topics: Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Corpus Striatum; Diencephalon; Female; Hydroxydopamines; Methotrexate; Oxidoreductases; Pteridines; Rats; Reserpine | 1974 |
Inhibition of high-affinity glial uptake of 14C-glutamate by folate.
Topics: Animals; Carbon Radioisotopes; Epilepsy; Extracellular Space; Folic Acid; Ganglia, Spinal; Glutamates; Kinetics; Methotrexate; Neuroglia; Phenytoin; Pteridines; Rats | 1974 |
Properties of thymidylate synthetase from dichloromethotrexate-resistant Lactobacillus casei.
Topics: Drug Resistance, Microbial; Enzyme Activation; Escherichia coli; Folic Acid; Glutamates; Kinetics; Lactobacillus; Mercaptoethanol; Methotrexate; Methylation; Molecular Weight; Pteridines; Spectrophotometry; Transferases; Tritium; Uracil Nucleotides | 1970 |
Studies of the metabolism of methotrexate by intestinal flora. I. Identification and study of biological properties of the metabolite 4-amino-4-deoxy-N 10 -methylpteroic acid.
Topics: Aniline Compounds; Animals; Bacteria; Benzoates; Cecum; Chromatography, Paper; Chromatography, Thin Layer; Feces; Infrared Rays; Methotrexate; Mice; Oxidation-Reduction; Pteridines; Spectrum Analysis; Tritium; Ultraviolet Rays | 1972 |
Dihydrofolate reductase from guinea pig liver and small intestine.
Topics: Animals; Enzymes; Guinea Pigs; Intestine, Small; Liver; Methotrexate; Pteridines; Pyrimidines; Species Specificity; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1966 |
Dihydropteridine reductase: implication on the regulation of catecholamine biosynthesis.
Topics: Adrenal Glands; Animals; Catecholamines; Cattle; Dihydroxyphenylalanine; Epinephrine; Feedback; Hydrolases; In Vitro Techniques; Methotrexate; Oxidoreductases; Pteridines; Spectrophotometry; Tyrosine | 1971 |
Ascorbic acid protection of Escherichia coli against radiation lethality in the presence of tetracyclines and other radiosensitizers.
Topics: Aminopterin; Anti-Bacterial Agents; Ascorbic Acid; Chloral Hydrate; Chlortetracycline; Cobalt Isotopes; Escherichia coli; Methotrexate; Nucleosides; Oxytetracycline; Phenazines; Pteridines; Radiation Protection; Radiation-Sensitizing Agents; Tetracycline | 1967 |
Potential folic acid antagonists. IV. Synthetic approaches to analogs of aminopterin and methotrexate. IV. The preparation of p-([(2,4-diamino-6-pteridinyl)methyl]amino)-benzoic acids.
Topics: Benzoates; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Methotrexate; Pteridines | 1970 |
Potential folic acid antagonists. 3. Deaza analogs of methotrexate. 3. 1- and 3-Deaza analogs of 2,4-diamino-6-[(n-methylanilino)methyl]pteridine.
Topics: Amines; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Methotrexate; Pteridines | 1968 |
Stimulation by pteridines of the uptake of amethopterin by human lymphocytes.
Topics: Aniline Compounds; Biological Transport; Carbon Isotopes; Humans; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Pteridines; Stimulation, Chemical; Triamterene | 1968 |
The enzymatic hydrolysis of folate analogues.
Topics: Aspartic Acid; Carboxypeptidases; Folic Acid; Glutamates; Methods; Methotrexate; Peptide Hydrolases; Pseudomonas; Pteridines; Soil Microbiology; Spectrophotometry | 1968 |
The metabolite of 3', 5'-dichloro-4-amino-4-deoxy-N10-methylpteroylglutamic acid (dichloromethotrexate).
Topics: Animals; Dogs; Feces; Glutamates; Humans; In Vitro Techniques; Liver; Methotrexate; Pteridines; Rabbits; Rats; Subcellular Fractions; Urine | 1965 |
Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.
Topics: Adrenal Medulla; Animals; Biopterins; Brain; Cattle; Cells, Cultured; Cricetinae; Guanosine Triphosphate; Methotrexate; Mice; Pteridines; Pterins; Rats | 1983 |
Inhibition of mammalian xanthine oxidase by folate compounds and amethopterin.
Topics: Allopurinol; Animals; Cattle; Folic Acid; Kinetics; Leucovorin; Methotrexate; Pteridines; Tetrahydrofolates; Time Factors; Xanthine Oxidase | 1984 |
Tetrahydrobiopterin is synthesized by separate pathways from dihydroneopterin triphosphate and from sepiapterin in adrenal medulla preparations.
Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chemical Phenomena; Chemistry; Guanosine Triphosphate; Methotrexate; Neopterin; Pteridines; Pterins | 1983 |
Effects of methotrexate on biopterin levels and synthesis in rat cultured pineal glands.
Topics: Animals; Biopterins; Cells, Cultured; Guanosine; Kinetics; L-Lactate Dehydrogenase; Male; Methotrexate; Oxidation-Reduction; Pineal Gland; Pteridines; Rats; Rats, Inbred Strains; Tetrahydrofolate Dehydrogenase | 1984 |
Biosynthesis of tetrahydrobiopterin in the presence of dihydrofolate reductase inhibitors.
Topics: Animals; Biopterins; Cell Line; Clone Cells; Folic Acid Antagonists; GTP Cyclohydrolase; Guanosine Triphosphate; Male; Methotrexate; Neuroblastoma; Pteridines; Rats; Rats, Inbred Strains | 1983 |
Methotrexate and folate binding to dihydrofolate reductase. Separate characterization of the pteridine and p-aminobenzoyl binding sites by resonance Raman spectroscopy.
Topics: Binding Sites; Escherichia coli; Folic Acid; Methotrexate; Protein Binding; Pteridines; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1981 |
A convenient preparation of tetrahydropteridines and tetrahydrofolate analogs. Synthesis of tetrahydro-3',5'-dichloromethotrexate.
Topics: Boranes; Dimethylamines; Methotrexate; Oxidation-Reduction; Pteridines; Tetrahydrofolates | 1980 |
Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; GTP Cyclohydrolase; Hypoxanthines; Kidney Tubules, Proximal; Methotrexate; Mice; Nitric Oxide; Osmolar Concentration; Pteridines; Pterins | 1995 |
PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.
Topics: Animals; Base Sequence; Cloning, Molecular; DNA Primers; Drug Resistance; Genes, Protozoan; Leishmania major; Methotrexate; Molecular Sequence Data; Mutagenesis, Insertional; Oxidoreductases; Pteridines | 1994 |
2,4-diamino-7-hydroxy-pteridines in biological fluids of patients on high-dose methotrexate.
Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines | 1993 |
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
Topics: Animals; Biopterins; Blotting, Western; Chromatography, Gel; Folic Acid; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Leishmania major; Methotrexate; Models, Chemical; Multienzyme Complexes; NADP; Oxidoreductases; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1997 |
Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways.
Topics: Animals; Cell Division; Drug Resistance; Folic Acid Antagonists; Humans; Leishmania; Methotrexate; Microbial Sensitivity Tests; Multienzyme Complexes; Mutation; Oxidoreductases; Pteridines; Pyrimidines; Quinazolines; Species Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1997 |
Tetrahydrobiopterin modulates cyclooxygenase-2 expression in human mesangial cells.
Topics: Biopterins; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Methotrexate; NG-Nitroarginine Methyl Ester; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Pteridines; Pterins; Quinoxalines; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1997 |
Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.
Topics: Animals; Biological Transport; Carrier Proteins; Cloning, Molecular; Dose-Response Relationship, Drug; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid; Genes, Protozoan; Leishmania; Methotrexate; Models, Biological; Molecular Sequence Data; Mutation; Pteridines; Receptors, Cell Surface | 1999 |
New gamma-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Folic Acid Antagonists; Glutamic Acid; Humans; Immunosuppressive Agents; Methotrexate; Mitogens; Molecular Structure; Pteridines; Pyrimidines; T-Lymphocytes | 2000 |
Target analogue imprinted polymers with affinity for folic acid and related compounds.
Topics: Folic Acid; Methotrexate; Polymers; Pteridines | 2001 |
Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Damage; Electron Transport; Humans; Hydrolysis; Methotrexate; Molecular Structure; Phosphorus Radioisotopes; Photolysis; Piperidines; Poly G; Pteridines; Spectrometry, Fluorescence | 2002 |
Allergic contact dermatitis in methotrexate manufacture.
Topics: Adult; Air Pollution, Indoor; Allergens; Cross Reactions; Dermatitis, Allergic Contact; Dermatitis, Occupational; Diagnosis, Differential; Facial Dermatoses; Humans; Male; Methotrexate; Neck; Patch Tests; Pteridines | 2003 |
Detection and measurement of antagonism to folic acid.
Topics: Folic Acid; Folic Acid Antagonists; Leucovorin; Methotrexate; Pteridines | 1957 |
A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS.
Topics: Alcohols; Aldehydes; Chromatography; Ethers; Fatty Acids; Folic Acid; Glycerol; Glyceryl Ethers; Liver; Methotrexate; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Pteridines; Pterins; Rats; Research; Stearic Acids | 1964 |
Determination of methotrexate, several pteridines, and creatinine in human urine, previous oxidation with potassium permanganate, using HPLC with photometric and fluorimetric serial detection.
Topics: Biomarkers; Chromatography, High Pressure Liquid; Creatinine; Fluorometry; Humans; Methotrexate; Oxidation-Reduction; Photometry; Potassium Permanganate; Pteridines; Ultraviolet Rays | 2005 |
Determination of dissociation constants of folic acid, methotrexate, and other photolabile pteridines by pressure-assisted capillary electrophoresis.
Topics: Electrophoresis, Capillary; Folic Acid; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methotrexate; Osmolar Concentration; Photochemistry; Potentiometry; Pressure; Pteridines; Spectrophotometry, Ultraviolet | 2006 |
Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model.
Topics: Aminopterin; Animals; Antimalarials; Disease Models, Animal; Folic Acid Antagonists; Malaria; Male; Methotrexate; Mice; Mice, Inbred ICR; Parasitemia; Plasmodium berghei; Pteridines; Random Allocation | 2008 |
A 245kb mini-chromosome impacts on Leishmania braziliensis infection and survival.
Topics: Animals; Cell Line; Chromosomes; Gene Amplification; Insect Vectors; Leishmania braziliensis; Leishmaniasis, Mucocutaneous; Macrophages; Membrane Transport Proteins; Methotrexate; Mice; Protozoan Proteins; Pteridines | 2009 |
Molecular structure, vibrational spectra and DFT molecular orbital calculations (TD-DFT and NMR) of the antiproliferative drug Methotrexate.
Topics: Acids; Cell Proliferation; Dimerization; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methotrexate; Models, Chemical; Molecular Conformation; Pteridines; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Vibration | 2010 |
Тhio-containing pteridines: Synthesis, modification, and biological activity.
Topics: Folic Acid Antagonists; Methotrexate; Pteridines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2022 |