pteridines and folic acid

pteridines has been researched along with folic acid in 158 studies

Research

Studies (158)

TimeframeStudies, this research(%)All Research%
pre-1990122 (77.22)18.7374
1990's11 (6.96)18.2507
2000's19 (12.03)29.6817
2010's5 (3.16)24.3611
2020's1 (0.63)2.80

Authors

AuthorsStudies
Turner, AJ1
Bonner, JT; Hall, EM; Pan, P1
Dinya, Z; Hernádi, FJ; Papp, S; Tóth-Martinez, BL1
Fukushima, T1
Graham, DW; Morman, H; Rogers, EF; Tolman, RL; Zimmerman, M1
Murphy, M; Scott, JM1
Fujino, S; Ikeda, M; Iwai, K1
Piper, WN; Van Lier, BL1
Reed, B; Scott, J; Weir, D1
Brown, GM; Fan, CL; Krivi, GG1
Scott, JM; Weir, DG1
Blair, JA; Leeming, RJ; Melikian, V; O'Gorman, DJ1
Gasco, MR2
Courtney, G; McNulty, H; McPartlin, J; Scott, J; Weir, D1
Ku, WW; Piper, WN1
Alam, A; Shen, RS; Zhang, YX1
Morrison, JF; Stone, SR1
Howells, DW; Hyland, K; Smith, I1
Andondonskaja-Renz, B; Zeitler, HJ1
Banks, SD; Bigham, EC; Nichol, CA; Smith, GK1
Newell, PC; Tillinghast, HS1
Granger, DN; Hollwarth, ME; McCord, JM; Parks, DA1
Kusano, G; Okinaka, O; Stokstad, EL1
Krungkrai, J; Webster, HK; Yuthavong, Y1
Hyland, K; Kendall, B; Smith, I1
Webber, S; Whiteley, JM1
Barnes, J; Hunter, R1
Sirotnak, FM1
Baugh, CM; Nair, MG1
Fukushima, T; Shiota, T2
Cooper, BA; Lavoie, A1
Buehring, KU; Shin, YS; Stokstad, EL1
Brade, W; Propping, P2
Iwai, K; Okinaka, O4
Brown, GM; Burg, AW1
Brown, GM; Richey, DP2
Baugh, CM; Dillard, R; Jackson, R; Shiota, T1
Summers, MR1
Brown, GM1
Hotchkiss, RD; Ortiz, PJ1
Zakrzewski, S1
Hecker, E; Marks, F1
Burchall, J1
Burchall, JJ; Hitchings, GH1
Gutteridge, WE; Jaffe, JJ; McCormack, JJ1
Butt, VS; Vaughan, PF1
Ortiz, PJ1
Dann, JG; Harding, NG; Newbold, PC; Whiteley, JM1
Godoy, GA; Soldo, AT1
Seifert, RM1
Bacher, A; Rappold, H2
Davies, J; Watkins, JC1
Doukas, PH; Miller, GH; Seydel, JK1
Kawai, M; Scrimgeour, KG1
Dunlap, RB; Ellis, PD; Lyon, JA1
Thijssen, HH1
Roberts, PJ1
Brown, GM; Jones, TH1
Luckner, M1
Weissbach, H; Whitfield, CD1
Brown, GM; Wolf, WA1
Dickerman, HW; Smith, BC1
Crusberg, TC; Kisliuk, RL; Leary, R1
Schlee, D; Zurnieden, K1
Kozloff, LM; Lute, M1
Desai, RB; Mankodi, BS; Rege, DV1
Kirschfeld, S; Lochmann, ER; Wacker, A1
Iwai, K; Okinaka, O; Suzuki, N1
Genther, CS; Kisliuk, RL; Roszmann, JH; Smith, CC1
Blair, JA; Dransfield, E1
Herken, H1
Huennekens, FM; Scrimgeour, KG; Vitols, KS; Vonderschmitt, DJ1
Beavon, JR; Blair, JA1
Baugh, CM1
Grzelakowska-Sztabert, B1
Baker, H; Frank, O; Hutner, SH1
Rembold, H; Vaubel, A1
Cihar, R; Slavík, K; Sonka, J; Straková, M1
Dewey, VC; Kidder, GW2
Odintsova, EN; Zhukova, SV1
Dewey, VC; Kidder, GW; Rembold, H1
utterworth, CE1
Drais, J; Huennekens, FM; Kirchner, J; Whiteley, JM1
Goldman, P; Levy, CC1
Trager, W1
Drais, JH; Huennekens, FM; Whiteley, JM1
Baker, BR; Ho, BT1
Baugh, CM; Krumdieck, CL; Shaw, E1
Jencks, WP; Kallen, RG1
Kawai, F; Mitsuda, H; Suzuki, Y; Tadera, K2
Palumbo, MP; Shiota, T; Tsai, L1
Neely, WB1
Huennekens, FM; Whiteley, JM1
Bublitz, C; Priest, RE1
Barr, FE1
Dhondt, JL1
Devreotes, PN1
Ferone, R; Spector, T1
Fleary, M; Lewis, AS; McCalla, C; Murphy, L; Purcell, S1
De Wit, RJ; Konijn, TM; van der Velden, RJ1
Cremer-Bartels, G; Ebels, I1
Benkovic, SJ1
Carey, PR; King, RW; Ozaki, Y1
De Saizieu, A; van Loon, AP; Vankan, P1
Adair, WL; Irby, RB1
Birdsall, B; Chau, DD; Cheung, HT; Feeney, J; Frenkiel, TA1
Beverley, SM; Hardy, LW; Nare, B1
Carl, GF; Hudson, FZ; McGuire, BS1
Rajagopalan, KV1
Haimeur, A; Kündig, C; Légaré, D; Ouellette, M; Papadopoulou, B1
Bagley, PJ; Selhub, J1
Ahmad, I; Akhtar, MJ; Khan, MA1
McPartlin, J; Quinlivan, EP; Scott, J; Weir, DG1
Beverley, SM; Cunningham, ML1
Chenon, K; De Lorenzi, E; Hall, AJ; Quaglia, M; Sellergren, B1
Rifkin, JL1
Gregory, JF; Hanson, AD1
Enzinger, C; Fuchs, D; Laich, A; Widner, B; Wirleitner, B1
Freisleben, A; Rychlik, M; Schieberle, P1
Braun, AM; Capparelli, AL; Lorente, C; Oliveros, E; Pokhrel, MR; Thomas, AH1
TOTTER, JR1
COLLIER, HO; GRIMSHAW, JJ; HUSKINSON, PL1
ANDERSON, ML; HERMAN, EC; WRIGHT, BE1
KAUFMAN, S1
KNAPP, A; MULLER, R1
KENNEDY, EP; LINDBERG, M; TIETZ, A1
BROWN, GM; REYNOLDS, JJ1
BONI, P; COLARUSSO, A; DE LERMA, B1
Basset, GJ; Díaz de la Garza, R; Gregory, JF; Hanson, AD; Klaus, SM; Quinlivan, EP1
Gregory, JF; Hanson, AD; Hugenholtz, J; Klaus, SM; Sybesma, W; Wegkamp, A1
Hirakawa, K1
Noszál, B; Szakács, Z1
De Lorenzi, E; Hall, AJ; Manesiotis, P; Quaglia, M; Sellergren, B1
Kolho, KL; Savilahti, E; Tikkakoski, S1
Ames, BN; Ayling, JE; Bailey, SW; Nozawa, M; Offer, T; Sabens, EA1
Díaz de la Garza, RI; Gregory, JF; Hanson, AD1
Allecca, S; Cavazzuti, A; Corona, P; Costi, MP; Ferrari, S; Gamarro, F; Gibellini, F; Hunter, WN; Loriga, M; McLuskey, K; Paglietti, G; Piras, S; Tulloch, L1
Beverley, SM; Garraway, LA; Nare, B; Vickers, TJ1
Beverley, SM; Vickers, TJ1
Dyer, RB; Li, G; Magana, D1
Duff, MR; Grubbs, J; Howell, EE; Serpersu, E1
Grigalavicius, M; Juraleviciute, M; Juzeniene, A; Ma, LW1
Engin, A; Engin, AB1
Agili, F; El-Kalyoubi, S1

Reviews

17 review(s) available for pteridines and folic acid

ArticleYear
Commentary: The roles of folate and pteridine derivatives in neurotransmitter metabolism.
    Biochemical pharmacology, 1977, Jun-01, Volume: 26, Issue:11

    Topics: Animals; Biogenic Amines; Brain; Folic Acid; Glycine; Humans; In Vitro Techniques; Mental Disorders; Methylation; Neurotransmitter Agents; Pteridines; Pterins; Subcellular Fractions

1977
Pterin-6-aldehyde production from folic acid by malignant tissues.
    Nutrition reviews, 1977, Volume: 35, Issue:7

    Topics: Erythrocytes; Folic Acid; Humans; Neoplasms; Pteridines; Pterins

1977
Lengths of poly-gamma-glutamyl chains in natural folates.
    Nutrition reviews, 1975, Volume: 33, Issue:4

    Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid; Glutamates; Lacticaseibacillus casei; Liver; Male; Oligopeptides; Oxidation-Reduction; Peptide Fragments; Peptides; Pteridines; Rats; Streptococcus

1975
Folate composition, synthesis and function in natural materials.
    Clinics in haematology, 1976, Volume: 5, Issue:3

    Topics: Animals; Bacteria; Bacteriophages; Bile; Brain; Cattle; Chickens; Folic Acid; Food; Glutamates; Haplorhini; Horses; Humans; Kidney; Liver; Mice; Plants; Pteridines; Rats

1976
Pteridines and mono-amines: relevance to neurological damage.
    Postgraduate medical journal, 1986, Volume: 62, Issue:724

    Topics: Amines; Biopterins; Folic Acid; Humans; Nervous System; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pteridines

1986
The biosynthesis of pteridines.
    Advances in enzymology and related areas of molecular biology, 1971, Volume: 35

    Topics: Aminobenzoates; Aminohydrolases; Escherichia coli; Folic Acid; Fructose-Bisphosphate Aldolase; Glutamates; Guanine Nucleotides; Guanosine Triphosphate; Isomerases; Kinetics; Phosphotransferases; Pteridines; Pterins; Spectrophotometry, Ultraviolet; Sulfonamides; Transferases

1971
Inhibition of folate biosynthesis and function as a basis for chemotherapy.
    Advances in enzymology and related areas of molecular biology, 1965, Volume: 27

    Topics: Aminobenzoates; Animals; Binding Sites; Biological Transport; Drug Resistance, Microbial; Drug Synergism; Escherichia coli; Folic Acid; Folic Acid Antagonists; Glutamates; Guinea Pigs; Humans; Lactobacillus; Leucovorin; Methotrexate; NAD; NADP; Pteridines; Pyrimidines; Rabbits; Rats; Sulfonamides

1965
[On new studies of the biosynthesis of N-heterocyclic compounds. 5. Formation and decomposition of substances with purine, pteridine, and benzopteridine ring systems].
    Die Pharmazie, 1966, Volume: 21, Issue:3

    Topics: Allantoin; Caffeine; Folic Acid; Heterocyclic Compounds; Methylation; Oxidation-Reduction; Pteridines; Purines; Pyrimidines; Theobromine

1966
[Biochemistry and physiology of the flavinogenesis in microorganisms].
    Die Pharmazie, 1970, Volume: 25, Issue:11

    Topics: Adenine; Bacteria; Biotransformation; Catalysis; Chemical Phenomena; Chemistry; Coenzymes; Enzyme Activation; Enzyme Repression; Flavonoids; Folic Acid; Fungi; Glycosides; Guanine Nucleotides; Lactates; Phosphates; Pteridines; Purines; Pyrimidines; Riboflavin; Ribose; RNA; Saccharomyces; Uracil; Xanthine Oxidase; Xanthines

1970
[The pathways of biosynthesis of pteridines and tetrahydrofolate].
    Postepy biochemii, 1967, Volume: 13, Issue:1

    Topics: Folic Acid; Pteridines

1967
Tetrahydrobiopterin deficiencies: preliminary analysis from an international survey.
    The Journal of pediatrics, 1984, Volume: 104, Issue:4

    Topics: Adjuvants, Pharmaceutic; Alcohol Oxidoreductases; Amino Acid Metabolism, Inborn Errors; Biopterins; Female; Folic Acid; GTP Cyclohydrolase; Humans; Infant; Infant, Newborn; Male; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Pteridines

1984
On the mechanism of action of folate- and biopterin-requiring enzymes.
    Annual review of biochemistry, 1980, Volume: 49

    Topics: Animals; Bacteria; Biopterins; Folic Acid; Formaldehyde; Formates; Glycine Hydroxymethyltransferase; Leukemia L1210; Liver; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mixed Function Oxygenases; Molecular Conformation; Oxidation-Reduction; Pteridines; Tetrahydrofolate Dehydrogenase

1980
Biosynthesis and processing of the molybdenum cofactors.
    Biochemical Society transactions, 1997, Volume: 25, Issue:3

    Topics: Biopterins; Coenzymes; Escherichia coli; Folic Acid; Metalloproteins; Molecular Structure; Molybdenum; Molybdenum Cofactors; Pteridines; Riboflavin; Sulfurtransferases

1997
Synthesis and turnover of folates in plants.
    Current opinion in plant biology, 2002, Volume: 5, Issue:3

    Topics: 4-Aminobenzoic Acid; Arabidopsis; Biological Transport; Carbon-Nitrogen Ligases; Enzymes; Folic Acid; Glutamic Acid; GTP Cyclohydrolase; Plants; Pteridines; Tetrahydrofolates; Transaminases

2002
Hyperhomocysteinemia, pteridines and oxidative stress.
    Current drug metabolism, 2002, Volume: 3, Issue:2

    Topics: Animals; Folic Acid; Homocysteine; Humans; Immunity; Oxidative Stress; Pteridines; Risk Factors; Vascular Diseases

2002
Folate metabolic pathways in Leishmania.
    Essays in biochemistry, 2011, Volume: 51

    Topics: Amino Acid Oxidoreductases; Animals; Carrier Proteins; Folic Acid; Host-Parasite Interactions; Iron-Sulfur Proteins; Leishmania; Metabolic Networks and Pathways; Methionine; Multienzyme Complexes; Pteridines; Purines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Transferases

2011
The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity.
    Advances in experimental medicine and biology, 2017, Volume: 960

    Topics: Animals; Folic Acid; Humans; Inflammation; Kynurenine; Methionine; Obesity; Pteridines; Signal Transduction

2017

Other Studies

141 other study(ies) available for pteridines and folic acid

ArticleYear
Determination of the active portion of the folic acid molecule in cellular slime mold chemotaxis.
    Journal of bacteriology, 1975, Volume: 122, Issue:1

    Topics: Agar; Aminobenzoates; Biological Assay; Cell-Free System; Cellophane; Chemical Phenomena; Chemistry; Chemotaxis; Chromatography, Thin Layer; Cyclic AMP; Drug Synergism; Folic Acid; Glutamates; Myxomycetes; Pteridines; Pyrazines; Pyrimidines; Species Specificity

1975
New vistas for P-aminobenzoate participation in the biosynthesis of dihydro folate: a tentative model of the tetrahydro folate multienzyme complex.
    Bio Systems, 1975, Volume: 7, Issue:1

    Topics: Adenylate Kinase; Aminobenzoates; Binding Sites; Escherichia coli; Folic Acid; Kinetics; Multienzyme Complexes; Phosphotransferases; Protein Binding; Protein Conformation; Pteridines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates

1975
[Biosynthesis of folic acid and biopterin (author's transl)].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1975, Volume: 20, Issue:7

    Topics: Adenosine Monophosphate; Animals; Biological Assay; Biopterins; Cyclic GMP; Folic Acid; Guanosine Triphosphate; Liver; Pteridines; Pterins; Purines; Rats; RNA; Trypanosoma

1975
Inhibitors of folate biosynthesis. 1. Inhibition of dihydroneopterin aldolase by pteridine derivatives.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:9

    Topics: Aldehyde-Lyases; Escherichia coli; Folic Acid; Pteridines

1977
The turnover catabolism and excretion of folate administered at physiological concentrations in the rat.
    Biochimica et biophysica acta, 1979, Apr-03, Volume: 583, Issue:4

    Topics: Animals; Female; Folic Acid; Glutamates; Male; Pteridines; Rats

1979
Nutritional requirements for folate compounds and some enzyme activities involved in the folate biosynthesis.
    Journal of nutritional science and vitaminology, 1977, Volume: 23, Issue:2

    Topics: Agaricales; Animals; Bacteria; Chickens; Dihydropteroate Synthase; Folic Acid; Fungi; Glutamates; Liver; Nutritional Requirements; Peptide Synthases; Pteridines; Pterins; Rats; Species Specificity; Transferases

1977
Pteridine regulation of inhibition of hepatic uroporphyrinogen L synthetase activity by lead chloride.
    Molecular pharmacology, 1977, Volume: 13, Issue:6

    Topics: Ammonia-Lyases; Animals; Binding, Competitive; Cytosol; Folic Acid; gamma-Glutamyl Hydrolase; Hydroxymethylbilane Synthase; In Vitro Techniques; Lead; Liver; Porphobilinogen Synthase; Protein Binding; Proteins; Pteridines; Rats

1977
The occurrence of folate-derived pteridines in rat liver.
    Clinical science and molecular medicine, 1978, Volume: 54, Issue:4

    Topics: Animals; Chromatography, Ion Exchange; Folic Acid; Liver; Male; Pteridines; Rats

1978
The conversion of dihydroneopterin triphosphate to sepiapterin by an enzyme system from Drosophila melanogaster.
    Biochemical and biophysical research communications, 1975, Dec-01, Volume: 67, Issue:3

    Topics: Animals; Drosophila melanogaster; Folic Acid; Guanosine Triphosphate; Pteridines; Spectrophotometry; Spectrophotometry, Ultraviolet

1975
Biopterin derivatives in human body fluids and tissues.
    Journal of clinical pathology, 1976, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Biological Assay; Biopterins; Body Fluids; Brain Chemistry; Chemical Phenomena; Chemistry; Child; Chromatography, DEAE-Cellulose; Culture Media; Eukaryota; Female; Folic Acid; Humans; Leukemia; Liver; Male; Methotrexate; Middle Aged; Milk, Human; Psoriasis; Pteridines

1976
[Complexes of pteridines with phenothiazine and phenoxazine derivatives].
    Il Farmaco; edizione scientifica, 1976, Volume: 31, Issue:11

    Topics: Folic Acid; Oxazines; Phenothiazines; Pteridines

1976
[Charge-transfer complexes of hematoporphyrin with pteridine derivatives].
    Il Farmaco; edizione scientifica, 1976, Volume: 31, Issue:4

    Topics: Buffers; Folic Acid; Hematoporphyrins; Leucovorin; Methotrexate; Pteridines; Solutions

1976
The quantitative analysis of endogenous folate catabolites in human urine.
    Analytical biochemistry, 1992, Nov-01, Volume: 206, Issue:2

    Topics: 4-Aminobenzoic Acid; Chromatography, High Pressure Liquid; Folic Acid; Glutamates; Humans; para-Aminobenzoates; Pteridines; Radioisotope Dilution Technique; Tritium

1992
Pteridine modulation of lead inhibition of uroporphyrinogen synthesis in erythroid precursor cells.
    Toxicology letters, 1990, Volume: 51, Issue:1

    Topics: Animals; Cell Line; Dialysis; Folic Acid; Hematopoietic Stem Cells; Heme; Lead; Leukemia, Erythroblastic, Acute; Mice; Porphyrinogens; Pteridines; Uroporphyrinogens

1990
Inhibition of GTP cyclohydrolase I by pterins.
    Biochimica et biophysica acta, 1988, Apr-14, Volume: 965, Issue:1

    Topics: Aminohydrolases; Animals; Biopterins; Folic Acid; GTP Cyclohydrolase; Kinetics; Liver; Neopterin; Oxidation-Reduction; Pteridines; Pterins; Rats; Xanthopterin

1988
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.
    Biochimica et biophysica acta, 1986, Feb-14, Volume: 869, Issue:3

    Topics: Animals; Binding, Competitive; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver; Methotrexate; NADP; Pteridines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim

1986
Evaluation of pteridines in patients with different tumors.
    Cancer detection and prevention, 1987, Volume: 10, Issue:1-2

    Topics: Adult; Aged; Erythrocytes; Folic Acid; Humans; Leukocytes; Middle Aged; Neoplasms; Pteridines

1987
On the substrate specificity of bovine liver dihydrofolate reductase: new unconjugated dihydropterin substrates.
    Archives of biochemistry and biophysics, 1987, May-01, Volume: 254, Issue:2

    Topics: Animals; Biopterins; Cattle; Folic Acid; Kinetics; Liver; Pteridines; Pterins; Substrate Specificity; Tetrahydrofolate Dehydrogenase

1987
Chemotaxis towards pteridines during development of Dictyostelium.
    Journal of cell science, 1987, Volume: 87 ( Pt 1)

    Topics: Actins; Chemical Phenomena; Chemistry; Chemotaxis; Dictyostelium; Folic Acid; Pteridines; Pterins; Time Factors; Xanthopterin

1987
Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine.
    Gastroenterology, 1986, Volume: 90, Issue:1

    Topics: Animals; Blood Proteins; Capillary Permeability; Cats; Folic Acid; Free Radicals; Ileum; Ischemia; Lymph; Pteridines; Pterins; Time Factors; Xanthine Oxidase

1986
Experiments on the biological activities of various fractions of the folic acid antagonist "X-methyl" folic acid.
    Archives of biochemistry and biophysics, 1986, Nov-15, Volume: 251, Issue:1

    Topics: Animals; Biological Assay; Folic Acid; Folic Acid Antagonists; Histidine; Liver; Oxidation-Reduction; Pteridines; Rats

1986
Guanosine triphosphate cyclohydrolase in Plasmodium falciparum and other Plasmodium species.
    Molecular and biochemical parasitology, 1985, Volume: 17, Issue:3

    Topics: Aminohydrolases; Animals; Chromatography, High Pressure Liquid; Erythrocytes; Folic Acid; Formates; GTP Cyclohydrolase; Kinetics; Neopterin; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Pteridines

1985
Clinical role of pteridine therapy in tetrahydrobiopterin deficiency.
    Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 1

    Topics: Amino Acid Metabolism, Inborn Errors; Biogenic Amines; Biopterins; Brain; Folic Acid; Folic Acid Deficiency; Humans; Infant; Phenylalanine; Phenylketonurias; Pteridines

1985
Comparative activity of rat liver dihydrofolate reductase with 7,8-dihydrofolate and other 7,8-dihydropteridines.
    Archives of biochemistry and biophysics, 1985, Feb-01, Volume: 236, Issue:2

    Topics: Animals; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Kinetics; Liver; Methotrexate; Osmolar Concentration; Pteridines; Rats; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Urea

1985
Toxicity of folic acid.
    Lancet (London, England), 1971, Apr-10, Volume: 1, Issue:7702

    Topics: Amines; Brain; Folic Acid; Humans; Pteridines

1971
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
    Biochimica et biophysica acta, 1973, Mar-15, Volume: 302, Issue:1

    Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim

1973
Synthesis and biological evaluation of isofolic acid.
    Journal of medicinal chemistry, 1974, Volume: 17, Issue:2

    Topics: Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; Isomerism; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Pteridines; Structure-Activity Relationship; Thymidine

1974
Biosynthesis of biopterin by Chinese hamster ovary (CHO K1) cell culture.
    The Journal of biological chemistry, 1974, Jul-25, Volume: 249, Issue:14

    Topics: Animals; Anura; Biological Assay; Carbon Radioisotopes; Cell Line; Chromatography, Gel; Chromatography, Ion Exchange; Cricetinae; Culture Media; Drosophila melanogaster; Eukaryota; Female; Folic Acid; Guanine; Guanine Nucleotides; Guanosine; Mice; Models, Chemical; Neuroblastoma; Ovary; Pteridines; Pterins; Purine Nucleotides; RNA; Structure-Activity Relationship

1974
Rapid transfer of folic acid from blood to bile in man, and its conversion into folate coenzymes and into a pteroylglutamate with little biological activity.
    Clinical science and molecular medicine, 1974, Volume: 46, Issue:6

    Topics: Adult; Aged; Aminobenzoates; Animals; Bile; Biological Assay; Biological Transport; Coenzymes; Dogs; Enterococcus faecalis; Folic Acid; Humans; Iodine Radioisotopes; Lacticaseibacillus casei; Liver; Middle Aged; Pediococcus; Pteridines; Rose Bengal; Tetrahydrofolates; Tritium; Ultrafiltration

1974
The metabolism of methotrexate in Lactobacillus casei and rat liver and the influence of methotrexate on metabolism of folic acid.
    The Journal of biological chemistry, 1974, Sep-25, Volume: 249, Issue:18

    Topics: Animals; Benzoates; Biological Assay; Carboxypeptidases; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enterococcus faecalis; Folic Acid; Glutamates; Kidney; Lacticaseibacillus casei; Liver; Male; Methotrexate; Oxidation-Reduction; Pteridines; Rats; Swine; Tetrahydrofolates; Tritium

1974
[Regeneration of the kidney after tubular damage by pteridine derivatives].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1969, Volume: 264, Issue:3

    Topics: Animals; DNA; Folic Acid; Glycosuria; Kidney Tubules; Pteridines; Pyrimidines; Rats; Regeneration; Ribosomes; RNA; Xanthopterin

1969
The biosynthesis of folic acid compounds in plants. IV. Purification and properties of the dihydropteroate-synthesizing enzyme from pea seedlings.
    The Journal of vitaminology, 1970, Volume: 16, Issue:3

    Topics: Adenosine Triphosphatases; Aminobenzoates; Chromatography, DEAE-Cellulose; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Ligases; Magnesium; Plants; Pteridines; Seeds; Spectrophotometry; Sulfonamides; Ultracentrifugation; Ultraviolet Rays; Vegetables

1970
The biosynthesis of folic acid compounds in plants. V. Reaction mechanism of the dihydropteroate-synthesizing enzyme from pea seedlings.
    The Journal of vitaminology, 1970, Volume: 16, Issue:3

    Topics: Adenosine Triphosphatases; Aminobenzoates; Chromatography, Gel; Chromatography, Paper; Folic Acid; Ligases; Magnesium; Phosphates; Phosphorus Isotopes; Plants; Pteridines; Seeds; Vegetables

1970
The biosynthesis of folic acid. 8. Purification and properties of the enzyme that catalyzes the production of formate from carbon atom 8 of guanosine triphosphate.
    The Journal of biological chemistry, 1968, May-10, Volume: 243, Issue:9

    Topics: Amidohydrolases; Arsenic; Carbon Isotopes; Chromatography, Gel; Chromatography, Ion Exchange; Escherichia coli; Folic Acid; Formates; Guanine Nucleotides; Kinetics; Molecular Weight; Phosphates; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Pteridines; Spectrum Analysis; Ultraviolet Rays

1968
The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid.
    The Journal of biological chemistry, 1969, Mar-25, Volume: 244, Issue:6

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Aminobenzoates; Autoradiography; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Diphosphates; Electrophoresis; Escherichia coli; Folic Acid; Hot Temperature; Kinetics; Ligases; Magnesium; Molecular Weight; Phosphorus Isotopes; Phosphotransferases; Pteridines

1969
The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate.
    Biochemistry, 1969, Volume: 8, Issue:12

    Topics: Adenosine Triphosphate; Aminobenzoates; Biological Assay; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Dialysis; Folic Acid; Glutamates; Kinetics; Lactobacillus; Ligases; Methods; Phosphoric Acids; Phosphorus Isotopes; Phosphotransferases; Pteridines; Quaternary Ammonium Compounds; Spectrophotometry; Ultraviolet Rays

1969
Reaction of N-bromosuccinimide with reduced ring systems. Apparent protection of glutamate dehydrogenase by reduced nicotinamide-adenine dinucleotide.
    Biochemistry, 1972, Aug-01, Volume: 11, Issue:16

    Topics: Bromine; Chemical Phenomena; Chemistry; Folic Acid; Glutamate Dehydrogenase; NAD; Oxidation-Reduction; Pteridines; Pyrrolidinones; Spectrophotometry; Succinimides; Ultraviolet Rays

1972
The enzymatic synthesis of dihydrofolate and dihydropteroate in cell-free preparations from wild-type and sulfonamide-resistant pneumococcus.
    Biochemistry, 1966, Volume: 5, Issue:1

    Topics: Adenosine Triphosphate; Aminobenzoates; Biological Assay; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; In Vitro Techniques; Magnesium; Molecular Biology; Mutation; Pteridines; Pterins; Streptococcus pneumoniae; Sulfanilamides

1966
On the mechanism of chemical and enzymatic reduction of folate and dihydrofolate.
    The Journal of biological chemistry, 1966, Jun-25, Volume: 241, Issue:12

    Topics: Chemical Phenomena; Chemistry; Deuterium; Folic Acid; NADP; Pteridines; Tetrahydrofolate Dehydrogenase; Tritium

1966
[On the metabolism and mechanism of action of estrogens. 8. The biogenesis and metabolism of 2-hydroxyestrone in relation to the formation of protein-bound and water soluble estrone metabolites and to NADPH oxidation in rat liver microsomes].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1966, Volume: 345, Issue:1

    Topics: Aminopterin; Animals; Carbon Isotopes; Cysteine; Estrone; Female; Folic Acid; Glutathione; Humans; Kinetics; Liver; Male; Microsomes; NADP; Oxidation-Reduction; Phenylalanine; Phosphates; Protein Binding; Pteridines; Rats; Steroids

1966
Protection of microbial dihydrofolate reductase against inactivation by pronase.
    Molecular pharmacology, 1968, Volume: 4, Issue:3

    Topics: Amines; Benzoates; Calcium; Chromatography; Endopeptidases; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Glutamates; Heterocyclic Compounds; Kinetics; Leucovorin; NAD; NADP; Protein Binding; Pteridines

1968
Presence and properties of dihydrofolate reductases within the genus Crithidia.
    Biochimica et biophysica acta, 1969, May-27, Volume: 178, Issue:3

    Topics: Animals; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Methotrexate; NADP; Pteridines; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Trypanosoma

1969
The hydroxylation of p-coumaric acid by an enzyme from leaves of spinach beet (Beta vulgaris L.).
    The Biochemical journal, 1969, Volume: 113, Issue:1

    Topics: Ascorbic Acid; Catechol Oxidase; Coumarins; Folic Acid; Mixed Function Oxygenases; NAD; NADP; Plants; Pteridines

1969
Dihydrofolate and dihydropteroate synthesis by partially purified enzynes from wild-type and sulfonamide-resistant pneumonococcus.
    Biochemistry, 1970, Jan-20, Volume: 9, Issue:2

    Topics: Aminobenzoates; Benzoates; Binding Sites; Biological Assay; Catalase; Centrifugation, Density Gradient; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Drug Resistance, Microbial; Enterococcus faecalis; Enzymes; Folic Acid; Glutamates; Kinetics; Magnesium; Manganese; Methods; Molecular Weight; Phosphoric Acids; Pteridines; Quaternary Ammonium Compounds; Species Specificity; Streptococcus pneumoniae; Sulfanilamides

1970
Single-step purification of dihydrofolate reductases on pteridine matrices.
    The Biochemical journal, 1972, Volume: 127, Issue:2

    Topics: Chromatography, Affinity; Folic Acid; Methods; Molecular Weight; NADP; Pteridines; Tetrahydrofolate Dehydrogenase

1972
A requirement for an unconjugated pteridine for the growth of Paramecium aurelia.
    Biochimica et biophysica acta, 1974, Oct-08, Volume: 362, Issue:3

    Topics: Chromatography, Gel; Culture Media; Darkness; Folic Acid; Light; Paramecium; Pteridines; Spectrometry, Fluorescence; Thymidine

1974
An approach to the chemical analysis of folic acid: gas chromatography of a degradation product from synthetic folic acid samples.
    Journal of the science of food and agriculture, 1974, Volume: 25, Issue:12

    Topics: Aminobenzoates; Chemical Phenomena; Chemistry; Chromatography, Gas; Evaluation Studies as Topic; Folic Acid; Methods; Pteridines

1974
Bacterial degradation of folic acid.
    Journal of general microbiology, 1974, Volume: 85, Issue:2

    Topics: Amidohydrolases; Aminohydrolases; Cell-Free System; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Flagella; Folic Acid; Mass Spectrometry; Microscopy, Electron; Pseudomonas; Pteridines; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

1974
Facilitatory and direct excitatory effects of folate and folinate on single neurones of cat cerebral cortex.
    Biochemical pharmacology, 1973, Jul-01, Volume: 22, Issue:13

    Topics: Acetylcholine; Aminobutyrates; Animals; Cats; Cerebral Cortex; Folic Acid; Glutamates; Iontophoresis; Leucovorin; Neurons; Pteridines

1973
Sulfonamide structure-activity relationship in a cell-free system. Correlation of inhibition of folate synthesis with antibacterial activity and physicochemical parameters.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:7

    Topics: Aniline Compounds; Anti-Bacterial Agents; Cell-Free System; Depression, Chemical; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Magnetic Resonance Spectroscopy; Pteridines; Pyridines; Structure-Activity Relationship; Sulfonamides

1972
Bibliography of paper and thin-layer chromatography 1966-1969. Vitamins.
    Journal of chromatography, 1972

    Topics: Ascorbic Acid; Bibliographies as Topic; Biotin; Chromatography; Chromatography, Paper; Chromatography, Thin Layer; Coenzyme A; Ergocalciferols; Fats; Flavins; Folic Acid; Growth Substances; Nicotinic Acids; Pantothenic Acid; Pteridines; Riboflavin; Solubility; Thiamine; Vitamin B 12; Vitamin E; Vitamin K; Vitamins; Water

1972
Reduction of folate by Ti 3+ .
    Canadian journal of biochemistry, 1972, Volume: 50, Issue:11

    Topics: Amines; Chemical Phenomena; Chemistry; Chromatography, Gel; Folic Acid; Kinetics; Osmolar Concentration; Oxidation-Reduction; Paraquat; Polarography; Pteridines; Spectrophotometry, Ultraviolet; Temperature; Titanium

1972
Assignment of the carbon-13 nuclear magnetic resonance spectrum of folic acid.
    Biochemistry, 1973, Jun-19, Volume: 12, Issue:13

    Topics: Aminobenzoates; Benzamides; Carbon Isotopes; Chemical Phenomena; Chemistry; Deuterium; Folic Acid; Glutamates; Magnetic Resonance Spectroscopy; Protons; Pteridines; Purines; Quinazolines; Quinoxalines; Ribonucleosides

1973
A simple method for preparing 2-amino-4-hydroxy-6-formylpteridine, a precursor of the pteridine substrate of dihydropteroate biosynthesis.
    Analytical biochemistry, 1973, Volume: 54, Issue:2

    Topics: Amines; Borohydrides; Bromine; Chemical Phenomena; Chemistry; Folic Acid; Oxidation-Reduction; Pteridines

1973
Inhibition of high-affinity glial uptake of 14C-glutamate by folate.
    Nature, 1974, Aug-02, Volume: 250, Issue:465

    Topics: Animals; Carbon Radioisotopes; Epilepsy; Extracellular Space; Folic Acid; Ganglia, Spinal; Glutamates; Kinetics; Methotrexate; Neuroglia; Phenytoin; Pteridines; Rats

1974
The biosynthesis of folic acid. VII. Enzymatic synthesis of pteridines from guanosine triphosphate.
    The Journal of biological chemistry, 1967, Sep-25, Volume: 242, Issue:18

    Topics: Biological Assay; Carbon Isotopes; Catalysis; Chromatography; Chromatography, Paper; Depression, Chemical; Escherichia coli; Folic Acid; Guanine Nucleotides; Pteridines; Spectrophotometry

1967
Binding of the folate substrate to 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase.
    The Journal of biological chemistry, 1970, Jan-25, Volume: 245, Issue:2

    Topics: Benzoates; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Escherichia coli; Folic Acid; Glutamates; Homocysteine; Mutation; Peptides; Pteridines; Temperature; Time Factors; Transferases

1970
The biosynthesis of folic acid. X. Evidence for an Amadori rearrangement in the enzymatic formation of dihydroneopterin triphosphate from GTP.
    Biochimica et biophysica acta, 1969, Dec-30, Volume: 192, Issue:3

    Topics: Amidohydrolases; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Electrophoresis; Escherichia coli; Folic Acid; Formates; Guanine Nucleotides; Kinetics; Paper; Pentosephosphates; Pteridines; Spectrophotometry; Ultraviolet Rays

1969
Aminoacyl formylmethionyl transfer ribonucleic acid transformylase. Inhibitor studies and the reversal of the reaction.
    Biochemistry, 1970, Mar-03, Volume: 9, Issue:5

    Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Escherichia coli; Folic Acid; Formates; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Methionine; Pteridines; RNA, Transfer; Transferases; Tritium

1970
Properties of thymidylate synthetase from dichloromethotrexate-resistant Lactobacillus casei.
    The Journal of biological chemistry, 1970, Oct-25, Volume: 245, Issue:20

    Topics: Drug Resistance, Microbial; Enzyme Activation; Escherichia coli; Folic Acid; Glutamates; Kinetics; Lactobacillus; Mercaptoethanol; Methotrexate; Methylation; Molecular Weight; Pteridines; Spectrophotometry; Transferases; Tritium; Uracil Nucleotides

1970
A comparison of the effectiveness with which p-aminobenzoic acid and p-aminobenzoylglutamic acid are used as substrate by dihydropteroate synthetase from Escherichia coli.
    Biochimica et biophysica acta, 1970, Oct-27, Volume: 222, Issue:1

    Topics: Aminobenzoates; Escherichia coli; Folic Acid; Glutamates; Ligases; Pteridines

1970
Folic acid, a structural component of T4 bacteriophage.
    Journal of molecular biology, 1965, Volume: 12, Issue:3

    Topics: Animals; Chromatography, Paper; Coliphages; Culture Media; Enterococcus faecalis; Escherichia coli; Fluorometry; Folic Acid; In Vitro Techniques; Lactobacillus; Pteridines; Spectrophotometry; Swine; Tryptophan; Viral Proteins

1965
Biosynthesis of folic acid. 3. Characterization of the genetic blocks in the pathway for pterinoid synthesis in microorganisms requiring folic acid.
    Archiv fur Mikrobiologie, 1966, May-09, Volume: 53, Issue:4

    Topics: Bacillus subtilis; Chromatography, Paper; Enterococcus faecalis; Eukaryota; Folic Acid; Genetics, Microbial; Lactobacillus; Pteridines

1966
[Biosynthesis and metabolism of folic acid and pteridines].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1967, Volume: 348, Issue:4

    Topics: Aldehydes; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Enterococcus faecalis; Eukaryota; Folic Acid; Leuconostoc; Pteridines; Pterins; Saccharomyces

1967
The biosynthesis of folic acid compounds in plants. I. Enzymatic formation of dihydropteroic acid and dihydrofolic acid from 2-amino-4-hydroxy-6-substituted pteridines by cell-free extracts of pea seedlings.
    The Journal of vitaminology, 1968, Jun-10, Volume: 14, Issue:2

    Topics: Biological Assay; Cell-Free System; Enterococcus faecalis; Folic Acid; Plants; Pteridines

1968
The biosynthesis of folic acid compounds in plants. II. Some properties of dihydropteroate-synthesizing enzyme in pea seedlings.
    The Journal of vitaminology, 1968, Jun-10, Volume: 14, Issue:2

    Topics: Barium; Biological Assay; Cadmium; Calcium; Cell-Free System; Cobalt; Copper; Enterococcus faecalis; Folic Acid; Hydrogen-Ion Concentration; Iron; Magnesium; Manganese; Mercury; Nickel; Plants; Pteridines

1968
Folate replacement by tetrahydrohomopteroate in triazine-resistant bacteria.
    Journal of bacteriology, 1971, Volume: 107, Issue:2

    Topics: Bacteriological Techniques; Benzoates; Culture Media; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Glucose; Growth Substances; Proguanil; Pteridines; Triazines

1971
Pterins in human urine.
    The Journal of biological chemistry, 1972, Jul-25, Volume: 247, Issue:14

    Topics: Administration, Oral; Animals; Anura; Biological Assay; Chromatography, Ion Exchange; Chromatography, Paper; Diet; Eukaryota; Folic Acid; Humans; Pteridines; Pterins; Purines; Spectrophotometry; Stereoisomerism; Ultraviolet Rays

1972
The urinary excretion of orally administered pteroyl-L-glutamic acid by the rat.
    The Biochemical journal, 1971, Volume: 123, Issue:5

    Topics: Administration, Oral; Animals; Antioxidants; Biological Assay; Carbon Isotopes; Chromatography, Thin Layer; Feces; Folic Acid; Kidney; Liver; Male; Pteridines; Rats

1971
[Biochemical processes during kidney regeneration after lesion with pteridine derivatives].
    Actualites pharmacologiques, 1971, Volume: 24

    Topics: Animals; Folic Acid; Hypertrophy; Kidney; Kidney Diseases; Organ Size; Pteridines; Rats; Regeneration

1971
Addition of bisulfite to folate and dihydrofolate.
    Archives of biochemistry and biophysics, 1967, Volume: 122, Issue:2

    Topics: Chemical Phenomena; Chemical Precipitation; Chemistry; Folic Acid; Hydrogen-Ion Concentration; Models, Chemical; Oxidation-Reduction; Pteridines; Spectrophotometry; Sulfites; Tetrahydrofolate Dehydrogenase

1967
Synthesis of (+ or minus)-5,10-methenyltetrahydrofolic acid-2 14 C and (+ or minus)-5-formyltetrahydrofolic acid-2 14 C.
    Analytical biochemistry, 1971, Volume: 44, Issue:2

    Topics: Carbon Isotopes; Chromatography, Thin Layer; Folic Acid; Isotope Labeling; Leucovorin; Methods; Oxidation-Reduction; Pteridines; Spectrophotometry; Ultraviolet Rays

1971
Role of 2-amino-4-hydroxypteridine-6-carboxaldehyde in folic acid biosynthesis.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 124, Issue:3

    Topics: Aldehydes; Escherichia coli; Folic Acid; Pteridines

1967
Antagonists of growth inhibition of Crithidia by allopurinol, a guanine analog.
    The Journal of protozoology, 1970, Volume: 17, Issue:2

    Topics: Allopurinol; Folic Acid; Hypoxanthines; Mercaptopurine; Pteridines; Thymidine; Trypanosoma

1970
[Acute renal failure after pteridine administration].
    Klinische Wochenschrift, 1970, Oct-15, Volume: 48, Issue:20

    Topics: Acute Kidney Injury; Animals; Anuria; Chlorothiazide; Diuretics; Folic Acid; Furosemide; Glomerular Filtration Rate; Kidney Function Tests; Kidney Tubules; Male; Pteridines; Pyrazines; Rats; Water-Electrolyte Balance; Xanthopterin

1970
Energy-dependent transport of pteridines into the trypanosomid flagellate, Crithidia fasciculata.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1970, Volume: 351, Issue:10

    Topics: Animals; Biological Transport; Cell Membrane; Chromatography; Cyanides; Dinitrophenols; Energy Transfer; Folic Acid; Folic Acid Antagonists; Potassium; Pteridines; Radioisotopes; Riboflavin; Trypanosoma; Vitamin B Complex

1970
The biosynthesis of folic acid compounds in plants. 3. Distribution of the dihydropteroate-synthesizing enzyme in plants.
    The Journal of vitaminology, 1970, Volume: 16, Issue:3

    Topics: Aminobenzoates; Carbon Isotopes; Cytoplasm; Folic Acid; Glycine max; Ligases; Mitochondria; Plants; Pteridines; Seeds; Vegetables

1970
The therapeutic effect of 2-amino-4-hydroxy-6-(1',2',3',4'-tetrahydroxybutyl)-5,6,7,8-tetrahydropteridine in x-irradiated mice.
    Radiation research, 1971, Volume: 45, Issue:3

    Topics: Animals; Folic Acid; Male; Mice; Oxidation-Reduction; Pteridines; Radiation Injuries, Experimental; Radiation-Protective Agents; Radiochemistry

1971
The use of Sephadex for the concentration of pteridines.
    Journal of chromatography, 1967, Volume: 31, Issue:2

    Topics: Animals; Chromatography, Ion Exchange; Dextrans; Drosophila; Fluorescence; Fluorometry; Folic Acid; Pteridines; Rhodospirillum; Tetrahymena

1967
[The yeast Rhodotorula flava B-322--an indicator for paraaminobenzoic acid].
    Doklady Akademii nauk SSSR, 1967, Jan-21, Volume: 172, Issue:3

    Topics: Aminobenzoates; Culture Media; Folic Acid; Glutamates; Indicators and Reagents; Pteridines; Yeasts

1967
The origin of unconjugated pteridines in Crithidia fasciculata.
    Archiv fur Mikrobiologie, 1967, Volume: 59, Issue:1

    Topics: Carbon Isotopes; Eukaryota; Folic Acid; Pteridines; Pterins

1967
Absorption and malabsorption of dietary folate.
    The American journal of clinical nutrition, 1968, Volume: 21, Issue:9

    Topics: Celiac Disease; Diet; Folic Acid; Glutamates; Humans; Intestinal Absorption; Malabsorption Syndromes; Pteridines; Sprue, Tropical

1968
Synthesis of 2-amino-4-hydroxy-6-formyl-7,8-dihydropteridine and its identification as a degradation product of dihydrofolate.
    Archives of biochemistry and biophysics, 1968, Sep-10, Volume: 126, Issue:3

    Topics: Folic Acid; Pteridines

1968
The enzymatic hydrolysis of folate analogues.
    Biochemical pharmacology, 1968, Volume: 17, Issue:11

    Topics: Aspartic Acid; Carboxypeptidases; Folic Acid; Glutamates; Methods; Methotrexate; Peptide Hydrolases; Pseudomonas; Pteridines; Soil Microbiology; Spectrophotometry

1968
2,4-diamino-5, 6,7,8-tetrahydroquinazoline, a new pteridine antagonist.
    Biochemical and biophysical research communications, 1969, Feb-21, Volume: 34, Issue:4

    Topics: Animals; Depression, Chemical; Eukaryota; Folic Acid; Growth; Pteridines; Pterins; Quinazolines; Thymidine; Thymine

1969
Pteridine requirement of the hemoflagellate Leishmania tarentolae.
    The Journal of protozoology, 1969, Volume: 16, Issue:2

    Topics: Animals; Flagella; Folic Acid; Leishmania; Pteridines

1969
Synthesis and properties of 2-amino-4-hydroxy-5,6-dimethyl-5,6,7,8-tetrahydropteridine and the 5,7-dimethyl isomer.
    Archives of biochemistry and biophysics, 1969, Volume: 133, Issue:2

    Topics: Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Coenzymes; Folic Acid; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methods; Methylation; Pteridines; Spectrum Analysis

1969
Analogs of tetrahydrofolic acid XXV. 2,4-Diamino-6-phenethylpteridine, an inhibitor of dihydrofolic reductase.
    Journal of pharmaceutical sciences, 1965, Volume: 54, Issue:9

    Topics: Aminopterin; Chemical Phenomena; Chemistry; Enzymes; Folic Acid; Pteridines; Pyrimidines; Tetrahydrofolate Dehydrogenase

1965
The chemical degradation of folic acid. Photolysis of 2,4,7-trihydroxypteridine.
    The Journal of biological chemistry, 1966, Jan-25, Volume: 241, Issue:2

    Topics: Chemical Phenomena; Chemistry; Folic Acid; Glyoxylates; Light; Pteridines; Ultraviolet Rays

1966
The dissociation constants of tetrahydrofolic acid.
    The Journal of biological chemistry, 1966, Dec-25, Volume: 241, Issue:24

    Topics: Chemical Phenomena; Chemistry; Folic Acid; Glutamates; Hydrogen-Ion Concentration; Pteridines; Spectrophotometry

1966
Biochemical studies on pteridines in plants. II. Biogenesis of folic acid in green leaves: enzymatic synthesis of dihydropteroic acid from guanosine compounds and mechanism of its synthetic pathway.
    The Journal of vitaminology, 1966, Sep-10, Volume: 12, Issue:3

    Topics: Adenosine Triphosphate; Aminobenzoates; Benzoates; Chemistry, Organic; Folic Acid; Guanine Nucleotides; Magnesium; Nucleosides; Organic Chemistry Phenomena; Plants; Pteridines

1966
A chemically prepared formamidopyrimidine derivative of guanosine triphosphate as a possible intermediate in pteridine biosynthesis.
    The Journal of biological chemistry, 1967, Apr-25, Volume: 242, Issue:8

    Topics: Chemistry, Organic; Chromatography; Folic Acid; Guanine Nucleotides; Iron; Lactobacillus; Mercaptoethanol; Organic Chemistry Phenomena; Pteridines

1967
Molecular orbital calculations on folic acid and folic acid analogs.
    Molecular pharmacology, 1967, Volume: 3, Issue:2

    Topics: Chemical Phenomena; Chemistry, Physical; Folic Acid; Folic Acid Antagonists; Pteridines; Tetrahydrofolate Dehydrogenase

1967
2-amino-4-hydroxy-6-methyl-7,8-dihydropteridine as a model for dihydrofolate.
    Biochemistry, 1967, Volume: 6, Issue:8

    Topics: Chemical Phenomena; Chemistry; Chromatography; Folic Acid; Hydrogen-Ion Concentration; Models, Chemical; Pteridines; Spectrum Analysis

1967
The influence of ascorbic acid and tetrahydropteridine on the synthesis of hydroxyproline by cultured cells.
    Laboratory investigation; a journal of technical methods and pathology, 1967, Volume: 17, Issue:4

    Topics: Animals; Ascorbic Acid; Carbon Isotopes; Culture Media; Culture Techniques; Dactinomycin; Folic Acid; Hydroxyproline; Mercaptoethanol; Mice; Mitosis; Pteridines; RNA; RNA, Messenger

1967
Melanin: the organizing molecule.
    Medical hypotheses, 1983, Volume: 11, Issue:1

    Topics: Animals; Central Nervous System; Chemical Phenomena; Chemistry; Endocrine Glands; Folic Acid; Glycoproteins; Glycosaminoglycans; Homeostasis; Humans; Melanins; Methylation; Neurotransmitter Agents; Polyamines; Pteridines; Purines

1983
The effect of folic acid on cAMP-elicited cAMP production in Dictyostelium discoideum.
    Developmental biology, 1983, Volume: 95, Issue:1

    Topics: Adaptation, Physiological; Chemotactic Factors; Cyclic AMP; Dictyostelium; Folic Acid; Pteridines

1983
Folic acid does not inactivate xanthine oxidase.
    The Journal of biological chemistry, 1984, Sep-10, Volume: 259, Issue:17

    Topics: Animals; Cattle; Female; Folic Acid; Kinetics; Milk; Pteridines; Pterins; Xanthine Oxidase

1984
Inhibition of mammalian xanthine oxidase by folate compounds and amethopterin.
    The Journal of biological chemistry, 1984, Jan-10, Volume: 259, Issue:1

    Topics: Allopurinol; Animals; Cattle; Folic Acid; Kinetics; Leucovorin; Methotrexate; Pteridines; Tetrahydrofolates; Time Factors; Xanthine Oxidase

1984
Characterization of the folic acid C9-N10-cleaving enzyme of Dictyostelium minutum V3.
    Journal of bacteriology, 1983, Volume: 154, Issue:2

    Topics: Aminohydrolases; Dictyostelium; Folic Acid; Glutamates; Hydrogen-Ion Concentration; Kinetics; Protozoan Proteins; Pteridines; Pterins; Species Specificity

1983
Bacterial degradation of folic acid.
    Methods in enzymology, 1980, Volume: 66

    Topics: Carboxypeptidases; Folic Acid; gamma-Glutamyl Hydrolase; Pseudomonas; Pteridines; Substrate Specificity

1980
Pteridines as nonretinal regulators of light-dependent melatonin biosynthesis.
    Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:5

    Topics: Acetylserotonin O-Methyltransferase; Animals; Cattle; Folic Acid; Light; Melatonin; Methyltransferases; Photochemistry; Pineal Gland; Pteridines; Pterins

1980
Methotrexate and folate binding to dihydrofolate reductase. Separate characterization of the pteridine and p-aminobenzoyl binding sites by resonance Raman spectroscopy.
    Biochemistry, 1981, May-26, Volume: 20, Issue:11

    Topics: Binding Sites; Escherichia coli; Folic Acid; Methotrexate; Protein Binding; Pteridines; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase

1981
Enzymic characterization of Bacillus subtilis GTP cyclohydrolase I. Evidence for a chemical dephosphorylation of dihydroneopterin triphosphate.
    The Biochemical journal, 1995, Mar-01, Volume: 306 ( Pt 2)

    Topics: Bacillus subtilis; Base Sequence; Binding, Competitive; Calcium; Folic Acid; Gene Expression; GTP Cyclohydrolase; Guanosine Triphosphate; Kinetics; Magnesium; Molecular Sequence Data; Neopterin; Operon; Phosphorylation; Plasmids; Potassium; Promoter Regions, Genetic; Pteridines; Recombinant Proteins; Uridine Triphosphate

1995
Proceedings of the 10th International Symposium on Chemistry and Biology of Pteridines and Folates. Orange Beach, Alabama, March 21-26, 1993.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Animals; Folic Acid; Humans; Pteridines

1993
Intermediates in the folic acid biosynthetic pathway are incorporated into molybdopterin the yeast, Pichia canadensis.
    The Journal of biological chemistry, 1994, Sep-30, Volume: 269, Issue:39

    Topics: Coenzymes; Folic Acid; Glucose; Guanosine; Metalloproteins; Molybdenum Cofactors; Pichia; Pteridines; Pterins

1994
13C NMR determination of the tautomeric and ionization states of folate in its complexes with Lactobacillus casei dihydrofolate reductase.
    Biochemistry, 1993, Jul-13, Volume: 32, Issue:27

    Topics: Binding Sites; Carbon Isotopes; Folic Acid; Ions; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Pteridines; Stereoisomerism; Tetrahydrofolate Dehydrogenase

1993
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
    The Journal of biological chemistry, 1997, May-23, Volume: 272, Issue:21

    Topics: Animals; Biopterins; Blotting, Western; Chromatography, Gel; Folic Acid; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Leishmania major; Methotrexate; Models, Chemical; Multienzyme Complexes; NADP; Oxidoreductases; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

1997
Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form.
    The Journal of nutrition, 1997, Volume: 127, Issue:11

    Topics: Administration, Oral; Animals; Anticonvulsants; Bile; Brain Chemistry; Diet; Dose-Response Relationship, Drug; Folic Acid; Glutamates; Intestinal Mucosa; Liver; Male; Phenytoin; Pteridines; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors

1997
Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.
    The EMBO journal, 1999, May-04, Volume: 18, Issue:9

    Topics: Animals; Biological Transport; Carrier Proteins; Cloning, Molecular; Dose-Response Relationship, Drug; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid; Genes, Protozoan; Leishmania; Methotrexate; Models, Biological; Molecular Sequence Data; Mutation; Pteridines; Receptors, Cell Surface

1999
Analysis of folate form distribution by affinity followed by reversed- phase chromatography with electrical detection.
    Clinical chemistry, 2000, Volume: 46, Issue:3

    Topics: Animals; Brain Chemistry; Cell Extracts; Chromatography, High Pressure Liquid; Electrochemistry; Folic Acid; Glutamates; Liver; Mice; Pteridines; Rats; Sensitivity and Specificity; Tissue Extracts

2000
Photodegradation of folic acid in aqueous solution.
    Journal of pharmaceutical and biomedical analysis, 1999, Volume: 19, Issue:3-4

    Topics: Chromatography, High Pressure Liquid; Folic Acid; Glutamates; Hydrogen-Ion Concentration; Kinetics; Photolysis; Pteridines; Solutions; Ultraviolet Rays; Water

1999
Mechanism of the antimicrobial drug trimethoprim revisited.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:15

    Topics: 4-Aminobenzoic Acid; Anti-Bacterial Agents; Escherichia coli; Folic Acid; Folic Acid Antagonists; Pteridines; Tetrahydrofolates; Trimethoprim

2000
Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy.
    Molecular and biochemical parasitology, 2001, Apr-06, Volume: 113, Issue:2

    Topics: Animals; Biopterins; Carrier Proteins; Chromatography, High Pressure Liquid; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Developmental; Humans; Leishmania; Leishmaniasis; Membrane Transport Proteins; Molecular Sequence Data; Multienzyme Complexes; Oxidoreductases; Protozoan Proteins; Pteridines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2001
Target analogue imprinted polymers with affinity for folic acid and related compounds.
    Journal of the American Chemical Society, 2001, Mar-14, Volume: 123, Issue:10

    Topics: Folic Acid; Methotrexate; Polymers; Pteridines

2001
Quantitative analysis of the behavior of Dictyostelium discoideum amoebae: stringency of pteridine reception.
    Cell motility and the cytoskeleton, 2002, Volume: 51, Issue:1

    Topics: Animals; Behavior, Animal; Carrier Proteins; Chemotaxis; Dictyostelium; Folate Receptors, GPI-Anchored; Folic Acid; Phosphates; Population Surveillance; Pseudopodia; Pteridines; Receptors, Cell Surface; Sensitivity and Specificity; Signal Transduction

2002
Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays.
    Journal of agricultural and food chemistry, 2002, Aug-14, Volume: 50, Issue:17

    Topics: 4-Aminobenzoic Acid; Chromatography, High Pressure Liquid; Deuterium; Folic Acid; Glutamic Acid; Isotope Labeling; Leucovorin; Magnetic Resonance Spectroscopy; Pteridines; Pterins; Spectrometry, Mass, Electrospray Ionization; Tetrahydrofolates

2002
Fluorescence of pterin, 6-formylpterin, 6-carboxypterin and folic acid in aqueous solution: pH effects.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2002, Volume: 1, Issue:6

    Topics: Fluorescence; Folic Acid; Hydrogen-Ion Concentration; Pteridines; Pterins; Solutions; Time Factors

2002
The biological functions of pteridine derivatives.
    Journal of cellular physiology. Supplement, 1953, Volume: 41, Issue:Suppl 1

    Topics: Biochemical Phenomena; Folic Acid; Humans; Pteridines

1953
Detection and measurement of antagonism to folic acid.
    British journal of pharmacology and chemotherapy, 1957, Volume: 12, Issue:4

    Topics: Folic Acid; Folic Acid Antagonists; Leucovorin; Methotrexate; Pteridines

1957
The role of polyglutamyl pteridine coenzymes in serine metabolism. III. The enzymatic formation of dihydrofolic acid and dihydroteropterin.
    The Journal of biological chemistry, 1958, Volume: 230, Issue:1

    Topics: Clostridium; Coenzymes; Folic Acid; Folic Acid Antagonists; Humans; Pteridines; Serine

1958
The nature of the primary oxidation product formed from tetrahydropteridines during phenylalanine hydroxylation.
    The Journal of biological chemistry, 1961, Volume: 236

    Topics: Folic Acid; Humans; Hydroxylation; Oxidation-Reduction; Phenylalanine; Pteridines

1961
[On the induction of phenylketonuria in rats and its influencing by folic acid and other pteridine derivatives].
    Ernahrungsforschung. Berichte und Mitteilungen, 1963, Volume: 8

    Topics: Animals; Folic Acid; Phenylketonurias; Pteridines; Pterins; Rats

1963
A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS.
    The Journal of biological chemistry, 1964, Volume: 239

    Topics: Alcohols; Aldehydes; Chromatography; Ethers; Fatty Acids; Folic Acid; Glycerol; Glyceryl Ethers; Liver; Methotrexate; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Pteridines; Pterins; Rats; Research; Stearic Acids

1964
BIOCHEMICAL STUDIES ON PTERIDINES IN PLANTS. I. BIOGENESIS OF FOLIC ACID IN GREEN LEAVES: CONFIRMATION OF ENZYMATIC SYNTHESIS OF FOLATE COMPOUNDS BY THE ENZYME SYSTEM FROM THE SPINACH.
    The Journal of vitaminology, 1965, Jun-10, Volume: 11

    Topics: 4-Aminobenzoic Acid; Enzyme Inhibitors; Folic Acid; Glutamates; Glycine max; Nucleotides; Pharmacology; Plant Leaves; Plants; Plants, Edible; Pteridines; Pterins; Research; Spinacia oleracea

1965
Enzymatic formation of the pteridine moiety of folic acid from guanine compounds.
    The Journal of biological chemistry, 1962, Volume: 237

    Topics: Folic Acid; Guanine; Humans; Nucleosides; Nucleotides; Pteridines; Pterins

1962
[Relations between the fluorescent spectra of folic acid and of other pteridins in aqueous solution].
    Bollettino della Societa italiana di biologia sperimentale, 1950, Volume: 26, Issue:4

    Topics: Coloring Agents; Folic Acid; Humans; Pteridines

1950
Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Sep-21, Volume: 101, Issue:38

    Topics: Aldehyde-Lyases; Amino Acid Sequence; Base Sequence; Chemical Engineering; DNA, Complementary; Folic Acid; Fruit; Genetic Vectors; Molecular Sequence Data; Open Reading Frames; Pteridines

2004
A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plants.
    The Journal of biological chemistry, 2005, Feb-18, Volume: 280, Issue:7

    Topics: Amino Acid Sequence; Diphosphates; Escherichia coli; Folic Acid; Kinetics; Lactococcus lactis; Magnesium; Manganese; Molecular Sequence Data; Neopterin; Nudix Hydrolases; Open Reading Frames; Phylogeny; Plants; Pteridines; Pyrophosphatases; Substrate Specificity

2005
Fluorometry of hydrogen peroxide using oxidative decomposition of folic acid.
    Analytical and bioanalytical chemistry, 2006, Volume: 386, Issue:2

    Topics: Carcinogens; Cations, Divalent; Copper; Fluorometry; Folic Acid; Hydrogen Peroxide; Oxidation-Reduction; Pteridines; Reactive Oxygen Species; Semicarbazides; Sodium Hypochlorite; Time Factors

2006
Determination of dissociation constants of folic acid, methotrexate, and other photolabile pteridines by pressure-assisted capillary electrophoresis.
    Electrophoresis, 2006, Volume: 27, Issue:17

    Topics: Electrophoresis, Capillary; Folic Acid; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methotrexate; Osmolar Concentration; Photochemistry; Potentiometry; Pressure; Pteridines; Spectrophotometry, Ultraviolet

2006
Polymeric receptors for the recognition of folic acid and related compounds via substructure imprinting.
    Analytical chemistry, 2006, Dec-15, Volume: 78, Issue:24

    Topics: Acrylamides; Binding Sites; Carboxylic Acids; Chromatography, High Pressure Liquid; Folic Acid; Glutamic Acid; Hydrogen-Ion Concentration; Polymers; Pteridines; Pyridines; Urea; Vitamin B Complex

2006
Undiagnosed coeliac disease and nutritional deficiencies in adults screened in primary health care.
    Scandinavian journal of gastroenterology, 2007, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Autoantibodies; Celiac Disease; Female; Folic Acid; GTP-Binding Proteins; HLA-DQ Antigens; Humans; Immunoglobulin A; Iron; Male; Malnutrition; Middle Aged; Primary Health Care; Protein Glutamine gamma Glutamyltransferase 2; Pteridines; Receptors, Transferrin; Transglutaminases

2007
5-Methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007, Volume: 21, Issue:9

    Topics: Ascorbic Acid; Chromatography, High Pressure Liquid; Depression, Chemical; DNA Breaks; DNA Damage; DNA, Superhelical; Folic Acid; Free Radical Scavengers; Oxidation-Reduction; Pentetic Acid; Photochemistry; Photosensitizing Agents; Pteridines; Rose Bengal; Singlet Oxygen; Sodium Azide; Superoxide Dismutase; Tetrahydrofolates; Ultraviolet Rays

2007
Folate biofortification of tomato fruit.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Mar-06, Volume: 104, Issue:10

    Topics: Carbon; Carbon-Nitrogen Ligases; Crosses, Genetic; Ethylenes; Folic Acid; Food, Fortified; Genetic Engineering; Genetic Techniques; Genetic Vectors; Plants, Genetically Modified; Pteridines; RNA, Plant; Solanum lycopersicum; Tetrahydrofolates; Transaminases; Vitamins

2007
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Feb-05, Volume: 105, Issue:5

    Topics: Animals; Antiprotozoal Agents; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Folic Acid; Isonipecotic Acids; Leishmania major; Oxidoreductases; Parasitic Sensitivity Tests; Protozoan Proteins; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trypanocidal Agents; Trypanosoma cruzi

2008
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.
    Current genetics, 2009, Volume: 55, Issue:3

    Topics: Animals; Biopterins; Drug Resistance; Folic Acid; Hydrogen Peroxide; Leishmania major; Methylnitronitrosoguanidine; Molsidomine; Multienzyme Complexes; Mutation; Nitric Oxide Donors; Nitroso Compounds; Oxidants; Oxidoreductases; Protozoan Proteins; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2009
Photoinduced electron transfer in folic acid investigated by ultrafast infrared spectroscopy.
    The journal of physical chemistry. B, 2012, Mar-15, Volume: 116, Issue:10

    Topics: Anions; Dimethyl Sulfoxide; Electron Transport; Folic Acid; Glutamates; Hydrogen-Ion Concentration; Pteridines; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Water

2012
Weak interactions between folate and osmolytes in solution.
    Biochemistry, 2012, Mar-20, Volume: 51, Issue:11

    Topics: 4-Aminobenzoic Acid; Binding Sites; Dimerization; Dimethyl Sulfoxide; Folic Acid; Kinetics; Osmolar Concentration; Pteridines; Solutions; Tetrahydrofolate Dehydrogenase

2012
Folic acid and its photoproducts, 6-formylpterin and pterin-6-carboxylic acid, as generators of reactive oxygen species in skin cells during UVA exposure.
    Journal of photochemistry and photobiology. B, Biology, 2016, Volume: 155

    Topics: Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Folic Acid; Humans; Keratinocytes; Photolysis; Pteridines; Pterins; Reactive Oxygen Species; Ultraviolet Rays

2016
Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3-
    Molecules (Basel, Switzerland), 2020, Nov-09, Volume: 25, Issue:21

    Topics: A549 Cells; Antineoplastic Agents; Binding Sites; Chemistry Techniques, Synthetic; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Folic Acid; Humans; Inhibitory Concentration 50; Janus Kinase 2; MCF-7 Cells; Molecular Docking Simulation; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Pteridines; Pyridines; Pyrimidines; Tetrahydrofolate Dehydrogenase; Tumor Suppressor Protein p53; Xanthine

2020