psymberin has been researched along with trifluoromethanesulfonic-acid* in 1 studies
1 other study(ies) available for psymberin and trifluoromethanesulfonic-acid
| Article | Year |
|---|---|
Eu(OTf)3-catalyzed highly regioselective nucleophilic ring opening of 2,3-epoxy alcohols: an efficient entry to 3-substituted 1,2-diol derivatives.
In our study of the total synthesis of (+)-irciniastatin A, we found a need to develop a method that enables a C3-selective nucleophilic ring opening of 2,3-epoxy alcohol by MeOH, by which we found that the use of combined catalytic amounts of Eu(OTf)3 and 2,6-di-tert-butyl-4-methylpyridine (DTBMP) enables the intended transformation to obtain 3-methoxy-1,2-diol efficiently. Promising features of a protocol that effects a highly regioselective nucleophilic ring opening of 2,3- and 3,4-epoxy alcohols using various nucleophiles including alcohols, thiols, and unprotected amines are described. Topics: Alcohols; Catalysis; Combinatorial Chemistry Techniques; Coumarins; Europium; Mesylates; Molecular Structure; Stereoisomerism | 2014 |