Page last updated: 2024-09-03

pseudomonas aeruginosa autoinducer and 4-butyrolactone

pseudomonas aeruginosa autoinducer has been researched along with 4-butyrolactone in 172 studies

Compound Research Comparison

Studies
(pseudomonas aeruginosa autoinducer)
Trials
(pseudomonas aeruginosa autoinducer)
Recent Studies (post-2010)
(pseudomonas aeruginosa autoinducer)
Studies
(4-butyrolactone)
Trials
(4-butyrolactone)
Recent Studies (post-2010) (4-butyrolactone)
20211094,456781,823

Research

Studies (172)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (5.81)18.2507
2000's60 (34.88)29.6817
2010's86 (50.00)24.3611
2020's16 (9.30)2.80

Authors

AuthorsStudies
Appleby, P; Bycroft, BW; Pritchard, DI; Sewell, H; Stewart, GS; Telford, G; Tomkins, PT; Wheeler, D; Williams, P1
Costerton, JW; Davies, DG; Greenberg, EP; Iglewski, BH; Parsek, MR; Pearson, JP1
Kolter, R; Losick, R1
Doroques, DB; Frank, DW; Gropper, MA; Kurahashi, K; Long, T; Ohara, M; Sawa, T; Twining, SS; Wiener-Kronish, JP1
Bouillant, ML; Nasser, W; Reverchon, S; Salmond, G1
Winans, SC1
Hoang, TT; Schweizer, HP1
Brun, P; Figarella, C; Kammouni, W; Lazdunski, A; Marchand-Pinatel, S; Merten, MD; Saleh, A; Tubul, A1
Bycroft, B; Camara, M; Chhabra, SR; Dunn, WR; Lawrence, RN; Williams, P; Wilson, VG1
Burnett, S; Elkins, JG; Fredericks, J; Hassett, DJ; Huang, CT; Iglewski, BH; Ma, JF; McDermott, TR; McFeters, G; Ochsner, UA; Passador, L; Stewart, PS; West, SE1
Holden, I; Swift, I; Williams, I1
Cámara, M; Chalker, VJ; Hardman, A; Kirke, D; Milton, DL; Williams, P1
Ceri, H; Parkins, MD; Storey, DG1
Fedyk, ER; Iglewski, BH; Mukaida, N; Phipps, RP; Smith, RS; Springer, TA1
Bennett, T; Bycroft, BW; Chhabra, SR; Gardiner, SM; Harty, C; Pritchard, DI; Williams, P1
Harris, SG; Iglewski, B; Phipps, R; Smith, RS1
Blanc, D; Favre-Bonté, S; Pache, JC; Pechère, JC; Robert, J; van Delden, C1
Croft, JM; King, JR; Koerber, AJ; Sockett, RE; Ward, JP; Williams, P1
Iglewski, BH; Kelly, R; Phipps, RP; Smith, RS1
Brooks, AI; Bushnell, D; Iglewski, BH; Passador, L; Wagner, VE1
Bu, Y; Smith, KM; Suga, H1
Cooley, MA; Rice, SA; Ritchie, AJ; Tanabe, KM; Yam, AO1
Horikawa, M; Ishiguro, M; Ishii, Y; Matsumoto, T; Miyairi, S; Pechere, JC; Standiford, TJ; Tateda, K; Yamaguchi, K1
Buch, C; Gram, L; Larsen, JL; Nielsen, J; Sigh, J1
Chun, CK; Greenberg, EP; Ozer, EA; Welsh, MJ; Zabner, J1
Hastings, JW1
Charlton, T; Fagerlind, MG; Harlén, M; James, S; Kjelleberg, S; Nilsson, P; Rice, SA1
Carty, NL; Griswold, JA; Hamood, AN; Patterson, EK; Rumbaugh, KP; Williams, SC1
Higashiyama, Y; Hirakata, Y; Imamura, Y; Kadota, J; Kohno, S; Miyazaki, Y; Mizuta, Y; Ohno, H; Seki, M; Tomono, K; Tsukamoto, K; Yanagihara, K1
Bycroft, BW; Chhabra, SR; Hooi, DS; Pritchard, DI; Williams, P1
Dutton, JM; Glansdorp, FG; Lee, JK; Salmond, GP; Spring, DR; Thomas, GL; Welch, M1
Hogan, DA; Kolter, R; Vik, A1
Cámara, M; Daykin, M; Joint, I; Milton, DL; Tait, K; Williams, P1
Cooley, MA; Jansson, A; Lysaght, P; Nilsson, P; Ritchie, AJ; Stallberg, J1
Bell, KS; Birch, PR; Carr, JP; Harris, SJ; Hyman, LJ; Matlin, AJ; Pemberton, CL; Robson, ND; Salmond, GP; Sebaihia, M; Toth, IK; Whitehead, NA1
Dong, YH; Greenberg, EP; Soo, HM; Zhang, LH; Zhang, XF1
Angelino, NJ; Chow, KC; Dolnick, BJ; Dolnick, R; Stephanie, LV; Sufrin, JR; Wu, Q1
Anguige, K; King, JR; Ward, JP1
Magnusson, KE; Pivoriūnas, A; Vikström, E1
Cámara, M; Chhabra, SR; Dessaux, Y; Oger, P; Uroz, S; Williams, P1
Brown, A; Bycroft, BW; Chhabra, SR; Pritchard, DI; Todd, I; Williams, P; Wood, P1
Cámara, M; Chhabra, SR; Cockayne, A; Hill, P; Middleton, B; Muharram, SH; O'Shea, P; Qazi, S; Williams, P1
Atkinson, S; Cámara, M; Sockett, RE; Williams, P1
Horikawa, M; Ishiguro, M; Ishii, Y; Miyairi, S; Takabatake, T; Tateda, K; Tuzuki, E; Ueda, C; Yamaguchi, K1
Pritchard, DI1
Brader, G; Koch, G; Palva, ET; Sjöblom, S1
Calfee, MW; Carty, NL; Colmer-Hamood, JA; Hamood, AN; Layland, N; Pesci, EC1
Brenner-Weiss, G; Hänsch, GM; Hug, F; Obst, U; Prior, B; Wagner, C; Zimmermann, S1
Bryan, A; Gyorke, S; Li, G; Martinez-Zaguilan, R; Rumbaugh, KP; Sennoune, S; Shiner, EK; Terentyev, D; Williams, SC1
Brenner-Weiss, G; Hänsch, GM; Hug, F; Müller, W; Obst, U; Prior, B; Wagner, C; Zimmermann, S1
Fuse, ET; Horikawa, M; Ishiguro, M; Ishii, Y; Miyairi, S; Saito, H; Standiford, TJ; Takabatake, T; Tateda, K; Ueda, C; Yamaguchi, K1
Duerkop, BA; Greenberg, EP; Hanzelka, BL; Hare, BJ; Heim, R; Müh, U; Olson, ER; Schuster, M1
Bourquard, N; Lusis, AJ; Ng, CJ; Ozer, EA; Parsek, MR; Reddy, ST; Shih, DM; Stoltz, DA; Yu, JM; Zabner, J1
Kirschhöfer, F; Marten, SM; Nusser, M; Obst, U; Schwartz, T; Walter, S1
Magnusson, KE; Tafazoli, F; Vikström, E1
Ikeda, T; Ishida, T; Kato, J; Kuroda, A; Ohtake, H; Takiguchi, N1
Janda, KD; Kaufmann, GF; Mee, JM; Park, J; Ulevitch, RJ1
Chowdhary, PK; Draganov, DI; Haines, DC; Haley, RW; Horke, S; Kramer, GL; Teiber, JF; Xiao, J1
Boontham, P; Cámara, M; Chandran, P; Chuthapisith, S; Eremin, O; McKechnie, A; Pritchard, D; Robins, A; Rowlands, BJ; Williams, P1
Conibear, TC; Thuruthyil, SJ; Willcox, MD; Zhu, H1
Janda, KD; Kaufmann, GF; Park, J1
Grauer, DC; Janda, KD; Katz, AZ; Kaufmann, GF; Kravchenko, VV; Lehmann, M; Mathison, JC; Meijler, MM; Scott, DA; Ulevitch, RJ1
de la Vega, L; Schmitz, ML1
Bui, L; Konradsson, P; Magnusson, KE; Vikström, E1
Brix, S; Cooley, M; Diggle, SP; Fink, LN; Froekiaer, H; Givskov, M; Lazenby, J; Skindersoe, ME; Whittall, C; Williams, P; Zeuthen, LH1
Kim, C; Kim, CK; Kim, J; Lee, JH; Park, HJ; Park, HY; Yoon, J1
Chen, J; Li, H; Lu, Z; Mao, Y; Song, J; Wang, L; Xia, C; Xie, X; Ye, L1
Gotoh, N; Horikawa, M; Ishiguro, M; Ishii, Y; Kimura, S; Miyairi, S; Tateda, K; Yamaguchi, K1
Dietl, J; Frambach, T; Hennicke, F; Rennemeier, C; Staib, P1
Koch, G; Nadal-Jimenez, P; Papaioannou, E; Quax, WJ; Setroikromo, R; Wahjudi, M1
Coenye, T; Cool, RH; Jimenez, PN; Koch, G; Krzeslak, J; Papaioannou, E; Quax, WJ; Wahjudi, M1
Altenhöfer, S; Chowdhary, PK; Förstermann, U; Goldeck, M; Haines, DC; Haley, RW; Horke, S; Kramer, GL; Teiber, JF; Wilgenbus, P; Witte, I; Xiao, J1
Cooley, MA; Rolph, MS; Whittall, C1
Collet, A; Cosette, P; Jouenne, T; Junter, GA; Nigaud, Y; Song, PC; Vaudry, D; Vaudry, H1
Buddrus-Schiemann, K; Fekete, A; Fischer, D; Hartmann, A; Hense, BA; Kuttler, C; Lucio, M; Müller, J; Rothballer, M; Schmitt-Kopplin, P1
Karatuna, O; Yagci, A1
Barrett, DA; Cámara, M; Cifelli, PM; Erskine, P; Givskov, M; Holland, ED; Knox, A; Lewis, S; Ortori, CA; Righetti, K; Smyth, AR; Williams, P1
Chen, J; Li, G; Li, H; Mao, Y; Song, J; Wang, L; Xia, C; Xie, X; Ye, L1
Bryan, A; Koenig, L; Li, G; Olmos, A; Rumbaugh, KP; Watters, C; Williams, SC; Youn, E1
Bertani, I; Bigirimana, J; Cabrio, L; Ferluga, S; Guarnaccia, C; Maraite, H; Mattiuzzo, M; Pongor, S; Venturi, V1
Janda, KD; Kaufmann, GF; Lowery, CA1
Kaufmann, GF; Kravchenko, VV; Ulevitch, RJ1
Cornelis, P; Crabbé, A; Leys, N; Nickerson, CA; Ott, CM; Sarker, SF; Van Houdt, R1
Abell, C; Bowden, SD; Hodgkinson, JT; Hollfelder, F; Huck, WT; Patil, SN; Shim, JU; Spring, DR; Welch, M1
Blohmke, CJ; Hancock, RE; Mayer, ML; Sheridan, JA; Turvey, SE1
Baldrich, E; García-Aljaro, C; Muñoz, FX1
Imperi, F; Leoni, L; Massai, F; Quattrucci, S; Visca, P; Zennaro, E1
Cool, RH; Hendrawati, O; Papaioannou, E; Poelarends, GJ; Quax, WJ; van Assen, AHG; van Merkerk, R; Wahjudi, M1
Akase, T; Asada, M; Huang, L; Ikeda, T; Minematsu, T; Morohoshi, T; Nagase, T; Nakagami, G; Ohta, Y; Sanada, H1
Chhabra, SR; Fischer, PM; Hooi, DS; Jadhav, GP; Kellam, B; Pritchard, DI; Righetti, K; Telford, G; Williams, P1
Baucher, M; Diallo, B; Duez, P; El Jaziri, M; Kiendrebeogo, M; Mol, A; Rajaonson, S; Rasamiravaka, T; Stévigny, C; Vandeputte, OM1
Cooke, A; Gaisford, W; Pritchard, DI1
Berliner, JA; Bourquard, N; Gong, KW; Grijalva, V; Kim, JB; Lee, S; Lusis, AJ; Meng, Y; Port, Z; Reddy, ST; Romanoski, CE; Shi, YS; Shih, DM; Xia, YR1
Chang, MW; Leong, SS; Ling, H; Lo, TM; Nguyen, HX; Poh, CL; Saeidi, N; Wong, CK1
Jarosz, LM; Krom, BP; Meijler, MM; Ovchinnikova, ES1
Fu, Z; Hum, L; Illek, B; Kong, W; Lopez-Guzman, M; Lynch, SV; Machen, TE; Patanwala, M; Schwarzer, C1
Balamurugan, K; Musthafa, KS; Pandian, SK; Ravi, AV1
Brenner-Weiss, G; Hänsch, GM; Kahle, NA; Obst, U; Overhage, J1
Huang, D; Lin, Y; Liu, W; Lu, Q; Yang, X; Zhang, X; Zhong, H1
Canning, BJ; Krasteva, G; Kummer, W; Papadakis, T1
Huang, L; Minematsu, T; Nagase, T; Nakagami, G; Paes, C; Sanada, H; Sari, Y1
Bobkiewicz, W; Boller, K; Ebinger, S; Husmann, M; Janda, KD; Kloft, N; Neukirch, C; von Hoven, G; Weis, S1
Bartolucci, N; Della Valle, M; Galloway, WR; Hodgkinson, JT; Ibbeson, BM; Morkunas, B; O'Connell, KM; Spring, DR; Welch, M; Wright, M1
Karlsson, T; Magnusson, KE; Turkina, MV; Vikström, E; Yakymenko, O1
Dy, RL; Hynes, MF; Komarovsky, VM; Major, AS; Ramsay, JP; Ronson, CW; Salmond, GP; Sullivan, JT1
Garner, AL; Janda, KD; Kaufmann, GF; Kravchenko, VV; Struss, AK; Yu, J1
Gotoh, N; Hatanaka, A; Hayashi, D; Imai, Y; Ishii, K; Kanno, E; Kawakami, K; Maruyama, R; Miyairi, S; Otomaru, H; Sato, S; Shibuya, N; Tachi, M; Tanno, H1
Abell, C; Bai, Y; Bowden, SD; Huck, WT; Pan, J; Patil, SN; Poulter, S; Salmond, GP; Welch, M1
Bourquard, N; Devarajan, A; Ganapathy, E; Gao, F; Grijalva, VR; Reddy, ST; Verma, J1
Delago, A; Inbal, B; Krief, P; Meijler, MM; Rabin, N1
Boon, C; Chen, S; Deng, Y; Lim, A; Zhang, LH1
Bezirtzoglou, E; Bleotu, C; Chifiriuc, MC; Holban, AM; Lazar, V1
Martínez, JL1
Ishizuka, S; Joe, GH; Maseda, H; Miyazaki, H; Nomura, N; Ohnishi, J; Shimizu, H; Taguchi, R; Tanaka, S1
Bernay, B; Gardères, J; Henry, J; Le Pennec, G; Müller, WE; Ritter, A; Wiens, M; Zatylny-Gaudin, C1
Adrian, TG; Chan, KG; Mohamad, NI; Muhamad Yunos, NY; Tan, PW; Tan, WS; Yin, WF1
Blackwell, HE; Gerdt, JP; McInnis, CE; Schell, TL1
Fu, Z; Li, C; Machen, TE; Morita, T; Neely, AM; Schwarzer, C; Whitt, AG1
Baba, N; Fukiya, S; Hagio, M; Ishizuka, S; Joe, GH; Lee, JY; Maseda, H; Miyazaki, H; Nomura, N; Nose, T; Shimizu, H; Taguchi, R; Tanaka, S; Yokota, A1
Golpasha, ID; Irani, S; Mousavi, SF; Owlia, P; Siadat, SD1
Byun, Y; Kim, HS; Kim, Y; Ok, K; Park, HD; Park, S1
Asada, M; Huang, L; Ikeda, S; Ikeda, T; Kanazawa, T; Minematsu, T; Morohoshi, T; Nagase, T; Nakagami, G; Sanada, H; Yamane, T1
Bortolotti, D; Carosella, ED; Di Luca, D; LeMaoult, J; Rizzo, R; Trapella, C1
Gotoh, N; Ishii, K; Kamimatsuno, R; Kanno, E; Kawakami, K; Maruyama, R; Miyairi, S; Miyasaka, T; Suzuki, A; Tachi, M; Takagi, N; Tanno, H1
Burlison, JA; Li, C; Lu, H; Machen, TE; Neely, AM; Schwarzer, C; Stivers, NS; White, C; Whitt, AG; Zhao, G1
Dapunt, U; Gaida, MM; Hänsch, GM1
Brown, JR; Dalchau, N; Federici, F; Grant, PK; Haseloff, J; Patange, O; Phillips, A; Rudge, TJ; Yordanov, B1
Holm, A; Magnusson, KE; Vikström, E1
Liu, J; Luo, Y; Ni, Y; Qian, X; Tao, S; Zhao, R1
Chen, X; Lou, Z; Tang, Y; Wang, H1
Forsythe, P; Han, S; Jang, H; Khambati, I; Pijnenburg, D1
Rousseau, S; Roussel, L1
Borges, A; Borges, F; Gaspar, A; Simões, M; Sousa, P; Vilar, S1
Chen, B; Fang, YL; He, YW; Jin, ZJ; Rampioni, G; Sun, S; Thawai, C; Zhou, L1
Blasco, L; Bou, G; Fernández-García, L; López, M; Mayer, C; Muras, A; Otero, A; Ruiz, FM; Tomás, M1
Agarwal, V; Kalia, M; Mani, A; Narvi, SS; Sharma, D; Singh, PK; Yadav, BS; Yadav, VK1
Bao, L; Huang, D; Lu, Q; Yu, J; Zhong, H1
Bondí, R; D'Angelo, F; Leoni, L; Longo, F; Messina, M; Rampioni, G; Visca, P1
González-Valdez, A; Morales, E; Servín-González, L; Soberón-Chávez, G1
Aksöz, N; Erdönmez, D; Rad, AY1
Balhouse, BN; Patterson, L; Schmelz, EM; Slade, DJ; Verbridge, SS1
Agarwal, V; Dohare, S; Kalia, M; Sharma, D; Singh, PK; Yadav, VK1
Burlison, JA; Li, C; Machen, TE; Meng, S; Neely, AM; Schwarzer, C; Stivers, NS; Whitt, AG; Zhao, G1
Fang, W; Jiang, D; Jiang, H; Liu, Y; Rao, S; Wu, M; Yuan, L1
Kanemaru, K; Nishimura-Danjobara, Y; Oyama, K; Oyama, Y; Takahashi, K; Yokoigawa, K1
Nishimura-Danjobara, Y; Oyama, K; Oyama, Y; Yokoigawa, K1
Cai, L; Geng, Y; Hua, C; Ni, Y; Niu, L; Tao, S; Zhao, R1
DeLateur, NA; Goldenfeld, N; Karig, D; Lu, T; Martini, KM; Weiss, R1
Agarwal, V; Kalia, M; Sharma, D; Singh, PK; Singh, SK; Yadav, VK1
Turkina, MV; Vikström, E1
Cai, L; Geng, Y; Hua, C; Ni, Y; Sun, Q; Tao, S; Zhao, R1
Amrein, MW; Chen, P; Cheng, J; Fan, Z; Fang, X; Kang, N; Li, N; Li, T; Lin, X; Lü, J; Meng, J; Mu, L; Ren, W; Ruan, H; Shi, Y; Shu, F; Song, D; Tu, Z; Wang, X; Wu, W; Xia, T; Xu, Y; Yan, LT; Zhu, J1
Agarwal, V; Sharma, D; Singh, PK; Singh, SK; Yadav, VK1
Agarwal, V; Kalia, M; Pandey, D; Sharma, D; Singh, PK; Yadav, VK1
Bedi, B; Goldberg, JB; Hart, CM; Koval, M; Maurice, NM; Sadikot, RT; Yuan, Z1
Chen, CY; Chung, YC; Tsai, CT; Tsai, TH; Wang, GH1
Hamamoto, H; Morohoshi, T; Ogasawara, Y; Someya, N; Xie, X1
Guo, J; Ikegame, M; Okamura, H; Yoshida, K1
Bandara, HMHN; Hewavitharana, AK; Samaranayake, LP; Shaw, PN; Smyth, HDC1
Grygier, A; Majcher, M; Myszka, K; Sobieszczańska, N; Szwengiel, A; Wolko, Ł1
Alcalde-Rico, M; Cámara, M; Halliday, N; Martínez, JL; Olivares-Pacheco, J1
Guo, J; Ikegame, M; Kamioka, H; Ochiai, K; Okamura, H; Qiu, L; Uchibe, K; Wang, Z; Weng, Y; Yoshida, K; Yuan, H1
Hu, R; Huang, X; Jin, X; Yuan, K; Zhang, Y; Zhao, Y; Zheng, J; Zhou, J1
Han, D; Pi, Y; Tao, S; Wang, J; Xiong, Y; Zhang, H1
Agarwal, V; Pandey, H; Sharma, D; Singh, PK; Singh, SK; Yadav, VK1
Geng, YF; Mei, J; Sun, YJ; Tao, SN; Yang, C; Zhang, XC; Zhang, Y; Zhao, BT1
Cheng, W; Tan, X; Tao, S; Wang, Z; Wei, H; Wu, Z; Xiong, Y; Yang, Y; Zhang, H; Zhu, X1
Combs, C; Gao, P; Guo, K; Khan, N; Lin, P; Pu, Q; Qin, S; Wang, Z; Wu, M; Xia, Z1
Chen, C; Li, MO; Li, S; Li, Y; Liu, J; Liu, Y; Lu, Y; Luo, Y; Wang, L; Zhang, W; Zhang, X; Zhang, Y1
Ahn, SH; Kim, SH; Oh, DJ; Shin, J1
Afonyushkin, VN; Cherepushkina, VS; Dimova, AS; Donchenko, NA; Koptev, VY; Mironova, TE; Nefedova, EV1
Jia, AQ; Khan, A; Li, JJ; Pan, D; Wang, XY; Wei, DQ; Yang, L; Zhou, JW1

Reviews

4 review(s) available for pseudomonas aeruginosa autoinducer and 4-butyrolactone

ArticleYear
Immune modulation by Pseudomonas aeruginosa quorum-sensing signal molecules.
    International journal of medical microbiology : IJMM, 2006, Volume: 296, Issue:2-3

    Topics: 4-Butyrolactone; Animals; Cell Communication; Homoserine; Humans; Immunologic Factors; Pseudomonas aeruginosa; Quinolones

2006
Modulation of translation and induction of autophagy by bacterial exoproducts.
    Medical microbiology and immunology, 2012, Volume: 201, Issue:4

    Topics: 4-Butyrolactone; Animals; Autophagy; Bacterial Toxins; Eukaryotic Initiation Factor-2; Hemolysin Proteins; Homoserine; Host-Pathogen Interactions; Humans; Phosphorylation; Protein Biosynthesis; Protein Processing, Post-Translational; Pseudomonas aeruginosa; Staphylococcus aureus

2012
Bacteria-Host Crosstalk: Sensing of the Quorum in the Context of Pseudomonas aeruginosa Infections.
    Journal of innate immunity, 2019, Volume: 11, Issue:3

    Topics: 4-Butyrolactone; Bacterial Adhesion; Biofilms; Calcium Signaling; Cell Movement; Homoserine; Host Microbial Interactions; Humans; Iron; Lipopolysaccharides; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing

2019
Quorum sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone: An all-rounder in mammalian cell modification.
    Journal of oral biosciences, 2020, Volume: 62, Issue:1

    Topics: 4-Butyrolactone; Animals; Homoserine; Humans; Lactones; Pseudomonas aeruginosa; Quorum Sensing

2020

Trials

1 trial(s) available for pseudomonas aeruginosa autoinducer and 4-butyrolactone

ArticleYear
Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial.
    Pediatric pulmonology, 2010, Volume: 45, Issue:4

    Topics: 4-Butyrolactone; Adolescent; Adult; Child; Cystic Fibrosis; Female; Garlic; Homoserine; Humans; Male; Middle Aged; Phytotherapy; Pilot Projects; Plant Oils; Plasma; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Respiratory Function Tests; Sputum; Treatment Outcome; Young Adult

2010

Other Studies

167 other study(ies) available for pseudomonas aeruginosa autoinducer and 4-butyrolactone

ArticleYear
The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity.
    Infection and immunity, 1998, Volume: 66, Issue:1

    Topics: 4-Butyrolactone; Adjuvants, Immunologic; Amino Acid Sequence; Animals; Cell Division; Cells, Cultured; Concanavalin A; Cytotoxicity Tests, Immunologic; Female; Hemocyanins; Homoserine; Humans; Immunoglobulin E; Immunoglobulin G; Interleukin-12; Interleukin-4; Jurkat Cells; Leukocytes, Mononuclear; Lipopolysaccharides; Lymphocytes; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Protein-Tyrosine Kinases; Pseudomonas aeruginosa; Signal Transduction; Spleen; Tumor Necrosis Factor-alpha; Virulence

1998
The involvement of cell-to-cell signals in the development of a bacterial biofilm.
    Science (New York, N.Y.), 1998, Apr-10, Volume: 280, Issue:5361

    Topics: 4-Butyrolactone; Bacterial Adhesion; Bacterial Proteins; Biofilms; Homoserine; Ligases; Mutation; Polysaccharides, Bacterial; Pseudomonas aeruginosa; Sodium Dodecyl Sulfate; Transcription Factors

1998
One for all and all for one.
    Science (New York, N.Y.), 1998, Apr-10, Volume: 280, Issue:5361

    Topics: 4-Butyrolactone; Bacterial Adhesion; Bacterial Physiological Phenomena; Biofilms; Homoserine; Pseudomonas aeruginosa

1998
In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections.
    Infection and immunity, 1998, Volume: 66, Issue:7

    Topics: 4-Butyrolactone; Animals; Cell Line; Endopeptidases; Homoserine; Humans; Lung; Lung Diseases; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Virulence

1998
Characterization of the Erwinia chrysanthemi expI-expR locus directing the synthesis of two N-acyl-homoserine lactone signal molecules.
    Molecular microbiology, 1998, Volume: 29, Issue:6

    Topics: 4-Butyrolactone; Amino Acid Sequence; Bacterial Proteins; Base Sequence; Binding Sites; Cloning, Molecular; Dickeya chrysanthemi; DNA, Bacterial; Genes, Bacterial; Homoserine; Molecular Sequence Data; Mutation; Pectobacterium carotovorum; Pheromones; Plants; Polygalacturonase; Polysaccharide-Lyases; Signal Transduction; Species Specificity; Trans-Activators

1998
Command, control and communication in bacterial pathogenesis.
    Trends in microbiology, 1998, Volume: 6, Issue:10

    Topics: 4-Butyrolactone; Bacterial Infections; Bacterial Proteins; DNA-Binding Proteins; Homoserine; Pheromones; Pseudomonas aeruginosa; Signal Transduction; Trans-Activators

1998
Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis.
    Journal of bacteriology, 1999, Volume: 181, Issue:17

    Topics: 4-Butyrolactone; Acylation; Anti-Infective Agents, Local; Base Sequence; Cloning, Molecular; DNA, Bacterial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Genes, Bacterial; Genome, Bacterial; Homoserine; Molecular Sequence Data; Oxidoreductases; Pseudomonas aeruginosa; Sequence Analysis, DNA; Triclosan

1999
Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells.
    Infection and immunity, 1999, Volume: 67, Issue:10

    Topics: 4-Butyrolactone; Cell Line; Cystic Fibrosis; Homoserine; Humans; Ibuprofen; Pseudomonas aeruginosa; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Messenger; Trachea

1999
The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, inhibits porcine arterial smooth muscle contraction.
    British journal of pharmacology, 1999, Volume: 128, Issue:4

    Topics: 4-Butyrolactone; Animals; Arteries; Female; Homoserine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Pseudomonas aeruginosa; Swine

1999
Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide.
    Molecular microbiology, 1999, Volume: 34, Issue:5

    Topics: 4-Butyrolactone; Biofilms; Catalase; Gene Expression Regulation, Bacterial; Homoserine; Hydrogen Peroxide; Methylphenazonium Methosulfate; Mutation; Oxidative Stress; Pseudomonas aeruginosa; Signal Transduction; Superoxide Dismutase; Transcription, Genetic

1999
New signal molecules on the quorum-sensing block.
    Trends in microbiology, 2000, Volume: 8, Issue:3

    Topics: 4-Butyrolactone; Bacterial Proteins; Diketopiperazines; DNA-Binding Proteins; Homoserine; Ligases; Piperazines; Pseudomonas aeruginosa; Quinolones; Signal Transduction; Trans-Activators; Transcription Factors

2000
The LuxM homologue VanM from Vibrio anguillarum directs the synthesis of N-(3-hydroxyhexanoyl)homoserine lactone and N-hexanoylhomoserine lactone.
    Journal of bacteriology, 2001, Volume: 183, Issue:12

    Topics: 4-Butyrolactone; Amino Acid Sequence; Animals; Bacterial Proteins; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cloning, Molecular; Escherichia coli; Fish Diseases; Gene Deletion; Genes, Bacterial; Homoserine; Lactones; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Oncorhynchus mykiss; Open Reading Frames; Polymerase Chain Reaction; Sequence Homology, Amino Acid; Signal Transduction; Vibrio; Virulence

2001
Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation.
    Molecular microbiology, 2001, Volume: 40, Issue:5

    Topics: 4-Butyrolactone; Alginates; Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Drug Resistance, Microbial; Glucuronic Acid; Hexuronic Acids; Homoserine; Microbial Sensitivity Tests; Mutation; Pseudomonas aeruginosa; Virulence

2001
IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Jul-01, Volume: 167, Issue:1

    Topics: 4-Butyrolactone; 5' Untranslated Regions; Cell Line; Cell-Free System; Cells, Cultured; Chemotaxis, Leukocyte; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epithelial Cells; Fibroblasts; Homoserine; Humans; Interleukin-8; Lung; Neutrophils; NF-kappa B; Promoter Regions, Genetic; Pseudomonas aeruginosa; Transcription Factor AP-1; Transcription Factor AP-2; Transcription Factors; Transcription, Genetic

2001
Haemodynamic effects of the bacterial quorum sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, in conscious, normal and endotoxaemic rats.
    British journal of pharmacology, 2001, Volume: 133, Issue:7

    Topics: 4-Butyrolactone; Animals; Antihypertensive Agents; Atenolol; Atrial Function; Atropine; Blood Pressure; Cardiovascular System; Consciousness; Dose-Response Relationship, Drug; Endotoxemia; Heart Atria; Heart Rate; Hemodynamics; Hindlimb; Homoserine; Kidney; Lipopolysaccharides; Male; Mesentery; Rats; Rats, Long-Evans; Regional Blood Flow; Structure-Activity Relationship

2001
The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo.
    Journal of bacteriology, 2002, Volume: 184, Issue:4

    Topics: 4-Butyrolactone; Animals; Cells, Cultured; Chemokines; Cyclooxygenase 2; Cytokines; Homoserine; Immunophenotyping; Isoenzymes; Keratinocytes; Lung; Mice; Mice, Inbred C57BL; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Pseudomonas aeruginosa; Skin; T-Lymphocytes; Th1 Cells; Virulence

2002
Detection of Pseudomonas aeruginosa cell-to-cell signals in lung tissue of cystic fibrosis patients.
    Microbial pathogenesis, 2002, Volume: 32, Issue:3

    Topics: 4-Butyrolactone; Adult; Bronchi; Cystic Fibrosis; Female; Homoserine; Humans; Lung; Male; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction

2002
A mathematical model of partial-thickness burn-wound infection by Pseudomonas aeruginosa: quorum sensing and the build-up to invasion.
    Bulletin of mathematical biology, 2002, Volume: 64, Issue:2

    Topics: 4-Butyrolactone; Burns; Homoserine; Humans; Models, Biological; Numerical Analysis, Computer-Assisted; Pseudomonas aeruginosa; Pseudomonas Infections

2002
The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Sep-01, Volume: 169, Issue:5

    Topics: 4-Butyrolactone; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Fibroblasts; Homoserine; Humans; Inflammation; Isoenzymes; Lung; Membrane Proteins; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Pseudomonas aeruginosa; RNA, Messenger; Up-Regulation; Virulence

2002
Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment.
    Journal of bacteriology, 2003, Volume: 185, Issue:7

    Topics: 4-Butyrolactone; Amino Acid Sequence; Bacterial Proteins; Cell Division; Culture Media; Gene Expression Regulation, Bacterial; Homeodomain Proteins; Homoserine; Molecular Sequence Data; Mutation; Oligonucleotide Array Sequence Analysis; Pseudomonas aeruginosa; Regulon; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction

2003
Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer.
    Chemistry & biology, 2003, Volume: 10, Issue:6

    Topics: 4-Butyrolactone; Aminophenols; Bacterial Proteins; Biofilms; DNA-Binding Proteins; Drug Design; Gene Library; Genes, Reporter; Genetic Techniques; Homoserine; Lactones; Molecular Structure; Pseudomonas aeruginosa; Quinolones; Signal Transduction; Structure-Activity Relationship; Trans-Activators; Virulence Factors

2003
Modification of in vivo and in vitro T- and B-cell-mediated immune responses by the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone.
    Infection and immunity, 2003, Volume: 71, Issue:8

    Topics: 4-Butyrolactone; Animals; B-Lymphocytes; Concanavalin A; Female; Homoserine; Immunity, Cellular; Immunization; Immunoglobulin G; In Vitro Techniques; Interferon-gamma; Interleukin-4; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mitogens; Ovalbumin; Pseudomonas aeruginosa; RNA, Messenger; T-Lymphocytes; Th1 Cells; Th2 Cells; Virulence

2003
The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils.
    Infection and immunity, 2003, Volume: 71, Issue:10

    Topics: 4-Butyrolactone; Animals; Apoptosis; Cell Line; Chemokine CCL2; Chemokine CXCL2; Chemokines; Homoserine; Humans; In Vitro Techniques; Macrophages; Mice; Mice, Inbred C57BL; Neutrophils; Pseudomonas aeruginosa; Pseudomonas Infections; U937 Cells; Virulence

2003
Production of acylated homoserine lactones by different serotypes of Vibrio anguillarum both in culture and during infection of rainbow trout.
    Systematic and applied microbiology, 2003, Volume: 26, Issue:3

    Topics: 4-Butyrolactone; Acylation; Animals; Colony Count, Microbial; Fish Diseases; Homoserine; Kidney; Liver; Macrophages; Muscles; Oncorhynchus mykiss; Respiratory Burst; Signal Transduction; Superoxides; Vibrio; Vibrio Infections

2003
Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Mar-09, Volume: 101, Issue:10

    Topics: 4-Butyrolactone; Animals; Cell Line; Cell Membrane; Cells, Cultured; CHO Cells; COS Cells; Cricetinae; Dogs; HeLa Cells; Homoserine; Humans; Immunity, Innate; Pseudomonas aeruginosa; Respiratory Mucosa; Signal Transduction; Virulence

2004
Bacterial quorum-sensing signals are inactivated by mammalian cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Mar-23, Volume: 101, Issue:12

    Topics: 4-Butyrolactone; Epithelium; Homoserine; Humans; Pseudomonas aeruginosa; Respiratory System; Signal Transduction

2004
The role of regulators in the expression of quorum-sensing signals in Pseudomonas aeruginosa.
    Journal of molecular microbiology and biotechnology, 2003, Volume: 6, Issue:2

    Topics: 4-Butyrolactone; Bacterial Proteins; Culture Media; Cyclic AMP Receptor Protein; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Homoserine; Humans; Models, Biological; Pseudomonas aeruginosa; Repressor Proteins; Signal Transduction; Trans-Activators; Transcription Factors

2003
Pseudomonas aeruginosa autoinducer enters and functions in mammalian cells.
    Journal of bacteriology, 2004, Volume: 186, Issue:8

    Topics: 4-Butyrolactone; Animals; Bacterial Proteins; Cell Nucleus; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Homoserine; Promoter Regions, Genetic; Pseudomonas aeruginosa; Recombinant Fusion Proteins; Signal Transduction; Trans-Activators; Transcription Factors

2004
Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 Cells.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:9

    Topics: 4-Butyrolactone; Anti-Bacterial Agents; Azithromycin; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Flavonoids; Homoserine; Humans; I-kappa B Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mucin 5AC; Mucins; Phosphorylation; Pseudomonas aeruginosa; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Up-Regulation

2004
Differential immune modulatory activity of Pseudomonas aeruginosa quorum-sensing signal molecules.
    Infection and immunity, 2004, Volume: 72, Issue:11

    Topics: 4-Butyrolactone; Concanavalin A; Gene Expression Regulation; Homoserine; Humans; Interleukin-2; Leukocytes, Mononuclear; Lipopolysaccharides; Lymphocyte Activation; Pseudomonas aeruginosa; Quinolones; Signal Transduction; Tumor Necrosis Factor-alpha

2004
Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation.
    Organic & biomolecular chemistry, 2004, Nov-21, Volume: 2, Issue:22

    Topics: 4-Butyrolactone; Biochemistry; Cyclohexanones; Drug Evaluation, Preclinical; Fluorine; Homoserine; Hydrolysis; Isomerism; Ketones; Molecular Probes; Pseudomonas aeruginosa; Serratia; Structure-Activity Relationship

2004
A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology.
    Molecular microbiology, 2004, Volume: 54, Issue:5

    Topics: 4-Butyrolactone; Antifungal Agents; beta-Galactosidase; Candida albicans; Dodecanol; Farnesol; Gene Expression Regulation, Fungal; Genes, Bacterial; Genes, Fungal; Genes, Reporter; Homoserine; Microscopy; Mutation; Pseudomonas aeruginosa; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Fungal; RNA, Messenger; Transcription, Genetic

2004
Disruption of quorum sensing in seawater abolishes attraction of zoospores of the green alga Ulva to bacterial biofilms.
    Environmental microbiology, 2005, Volume: 7, Issue:2

    Topics: 4-Butyrolactone; Bacterial Proteins; Biofilms; Cell Adhesion; Chemotactic Factors; Diffusion; Homoserine; Hydrogen-Ion Concentration; Metalloendopeptidases; Mutation; Seawater; Temperature; Ulva; Vibrio

2005
The Pseudomonas aeruginosa quorum-sensing molecule N-3-(oxododecanoyl)-L-homoserine lactone inhibits T-cell differentiation and cytokine production by a mechanism involving an early step in T-cell activation.
    Infection and immunity, 2005, Volume: 73, Issue:3

    Topics: 4-Butyrolactone; Animals; Animals, Genetically Modified; CD4-Positive T-Lymphocytes; Cell Differentiation; Cytokines; Genes, T-Cell Receptor; Homoserine; Lymphocyte Activation; Male; Mice; Pseudomonas aeruginosa; Signal Transduction; Specific Pathogen-Free Organisms; T-Lymphocytes

2005
Novel quorum-sensing-controlled genes in Erwinia carotovora subsp. carotovora: identification of a fungal elicitor homologue in a soft-rotting bacterium.
    Molecular plant-microbe interactions : MPMI, 2005, Volume: 18, Issue:4

    Topics: 4-Butyrolactone; Amino Acid Sequence; Bacterial Proteins; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Complementation Test; Homoserine; Molecular Sequence Data; Mutagenesis; Pectobacterium carotovorum; Recombinant Fusion Proteins; Sequence Alignment; Solanum tuberosum

2005
The two-component response regulator PprB modulates quorum-sensing signal production and global gene expression in Pseudomonas aeruginosa.
    Molecular microbiology, 2005, Volume: 56, Issue:5

    Topics: 4-Butyrolactone; Amino Acid Sequence; Bacterial Proteins; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Genes, Reporter; Homoserine; Ligases; Molecular Sequence Data; Movement; Mutagenesis, Insertional; Oligonucleotide Array Sequence Analysis; Pseudomonas aeruginosa; Sequence Alignment; Signal Transduction; Trans-Activators; Transcription Factors; Virulence Factors

2005
Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells.
    Cancer research, 2005, Jul-01, Volume: 65, Issue:13

    Topics: 4-Butyrolactone; Antineoplastic Combined Chemotherapy Protocols; Biomimetic Materials; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Drug Synergism; Fluorouracil; Homoserine; Humans; Isoenzymes; Phosphorylation; Protein Isoforms; RNA, Antisense; Signal Transduction; Thymidylate Synthase; Tubulin

2005
Modelling antibiotic- and anti-quorum sensing treatment of a spatially-structured Pseudomonas aeruginosa population.
    Journal of mathematical biology, 2005, Volume: 51, Issue:5

    Topics: 4-Butyrolactone; Anti-Bacterial Agents; Biofilms; Homoserine; Humans; Mathematics; Models, Biological; Pseudomonas aeruginosa; Signal Transduction; Virulence

2005
The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone stimulates phagocytic activity in human macrophages through the p38 MAPK pathway.
    Microbes and infection, 2005, Volume: 7, Issue:15

    Topics: 4-Butyrolactone; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Homoserine; Humans; Immunoblotting; Immunologic Factors; Macrophages; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Pseudomonas aeruginosa; Reactive Oxygen Species; Signal Transduction; Time Factors

2005
N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities.
    Microbiology (Reading, England), 2005, Volume: 151, Issue:Pt 10

    Topics: 4-Butyrolactone; Amidohydrolases; Dansyl Compounds; Gene Expression Regulation, Bacterial; Homoserine; Hydrogen-Ion Concentration; Oxidoreductases; Rhodococcus; Signal Transduction; Temperature

2005
Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosa signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone.
    Acta diabetologica, 2005, Volume: 42, Issue:3

    Topics: 4-Butyrolactone; Adjuvants, Immunologic; Animals; Diabetes Mellitus; Dimethyl Sulfoxide; Disease Models, Animal; Homoserine; Inflammation; Islets of Langerhans; Mice; Mice, Inbred NOD; Pancreatic Diseases; Pseudomonas aeruginosa

2005
N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus.
    Infection and immunity, 2006, Volume: 74, Issue:2

    Topics: 4-Butyrolactone; Bacterial Proteins; Cell Membrane; Down-Regulation; Exotoxins; Gene Expression Regulation, Bacterial; Homoserine; Pseudomonas aeruginosa; Signal Transduction; Staphylococcus aureus; Trans-Activators; Virulence

2006
Quorum sensing and the lifestyle of Yersinia.
    Current issues in molecular biology, 2006, Volume: 8, Issue:1

    Topics: 4-Butyrolactone; Bacterial Proteins; Base Sequence; Cell Movement; Gene Expression Regulation, Bacterial; Homoserine; Molecular Sequence Data; Repressor Proteins; Signal Transduction; Trans-Activators; Transcription Factors; Yersinia

2006
Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.
    Bioorganic & medicinal chemistry letters, 2006, Apr-15, Volume: 16, Issue:8

    Topics: 4-Butyrolactone; Apoptosis; Cells, Cultured; Homoserine; Hydrophobic and Hydrophilic Interactions; Macrophages; Pseudomonas; Structure-Activity Relationship

2006
Cooperation of two distinct ExpR regulators controls quorum sensing specificity and virulence in the plant pathogen Erwinia carotovora.
    Molecular microbiology, 2006, Volume: 60, Issue:6

    Topics: 4-Butyrolactone; Amino Acid Sequence; Bacterial Proteins; Cell Wall; Cellulase; Gene Expression Regulation, Bacterial; Homoserine; Molecular Sequence Data; Pectobacterium carotovorum; Phenotype; Plant Diseases; Plant Proteins; Repressor Proteins; RNA-Binding Proteins; Signal Transduction; Virulence

2006
PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1.
    Molecular microbiology, 2006, Volume: 61, Issue:3

    Topics: 4-Butyrolactone; Bacterial Proteins; Gene Expression Regulation, Bacterial; Glycolipids; Homoserine; Metalloendopeptidases; Mutation; Operon; Pseudomonas aeruginosa; Pyocyanine; Quinolones; Transcription Factors; Virulence Factors

2006
The quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN).
    Analytical and bioanalytical chemistry, 2007, Volume: 387, Issue:2

    Topics: 4-Butyrolactone; Bacteria; Biofilms; Cell Communication; Cells, Cultured; Chemotaxis, Leukocyte; Homoserine; Humans; Immunity; Neutrophil Activation; Phagocytosis; Pseudomonas aeruginosa; Quorum Sensing; Receptors, Immunologic; Up-Regulation

2007
Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signalling.
    Cellular microbiology, 2006, Volume: 8, Issue:10

    Topics: 4-Butyrolactone; Animals; Apoptosis; Calcium Signaling; Cytosol; Endoplasmic Reticulum; Endothelial Cells; Fibroblasts; Flow Cytometry; Homoserine; Humans; Inflammation; Inositol 1,4,5-Trisphosphate Receptors; Mice; NIH 3T3 Cells; Pseudomonas aeruginosa; Reverse Transcriptase Polymerase Chain Reaction; Virulence Factors

2006
Induction of neutrophil chemotaxis by the quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone.
    Infection and immunity, 2006, Volume: 74, Issue:10

    Topics: 4-Butyrolactone; Biofilms; Chemotaxis, Leukocyte; Homoserine; Humans; Neutrophils; Pseudomonas aeruginosa; Signal Transduction

2006
Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection.
    Journal of medical microbiology, 2006, Volume: 55, Issue:Pt 10

    Topics: 4-Butyrolactone; Animals; Antibodies, Bacterial; Apoptosis; Cell Line; Colony Count, Microbial; Homoserine; Immune Sera; Injections, Subcutaneous; Lung; Macrophages; Mice; Mice, Inbred BALB C; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Serum Albumin, Bovine; Tumor Necrosis Factor-alpha; Vaccination; Vaccines, Conjugate; Vaccines, Synthetic

2006
A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Nov-07, Volume: 103, Issue:45

    Topics: 4-Butyrolactone; Bacterial Proteins; DNA-Binding Proteins; Escherichia coli; Homoserine; Models, Molecular; Molecular Mimicry; Molecular Structure; Pseudomonas aeruginosa; Quorum Sensing; Repressor Proteins; Signal Transduction; Trans-Activators

2006
Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:4

    Topics: 4-Butyrolactone; Animals; Aryldialkylphosphatase; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Epithelial Cells; Homoserine; Humans; Mice; Mice, Knockout; Pseudomonas aeruginosa; Quorum Sensing; Trachea

2007
Use of quantitative real-time RT-PCR to analyse the expression of some quorum-sensing regulated genes in Pseudomonas aeruginosa.
    Analytical and bioanalytical chemistry, 2007, Volume: 387, Issue:2

    Topics: 4-Butyrolactone; Biofilms; Gene Expression Regulation, Bacterial; Homoserine; Pseudomonas aeruginosa; Quorum Sensing; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2007
Pseudomonas aeruginosa quorum sensing molecule N-(3 oxododecanoyl)-l-homoserine lactone disrupts epithelial barrier integrity of Caco-2 cells.
    FEBS letters, 2006, Dec-22, Volume: 580, Issue:30

    Topics: 4-Butyrolactone; Actins; Caco-2 Cells; Cell Adhesion; Cell Proliferation; Dextrans; Electric Impedance; Enzyme Activation; Epithelial Cells; Homoserine; Humans; Membrane Proteins; Microscopy, Electron, Scanning; Mitogen-Activated Protein Kinases; Occludin; Phosphoproteins; Protein Kinase Inhibitors; Pseudomonas aeruginosa; Quorum Sensing; Zonula Occludens-1 Protein

2006
Inhibition of quorum sensing in Pseudomonas aeruginosa by N-acyl cyclopentylamides.
    Applied and environmental microbiology, 2007, Volume: 73, Issue:10

    Topics: 4-Butyrolactone; Adaptation, Physiological; Anti-Bacterial Agents; beta-Galactosidase; Biofilms; Cyclopentanes; Genes, Reporter; Glycolipids; Homoserine; Pancreatic Elastase; Pseudomonas aeruginosa; Pyocyanine; Quorum Sensing; Virulence Factors

2007
The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone.
    Molecular immunology, 2008, Volume: 45, Issue:9

    Topics: 4-Butyrolactone; Animals; Antibodies, Monoclonal; Cell Line; Cells, Cultured; Enzyme Activation; Haptens; Homoserine; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Pseudomonas aeruginosa; Quorum Sensing

2008
Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone.
    Infection and immunity, 2008, Volume: 76, Issue:6

    Topics: 4-Butyrolactone; Animals; Aryldialkylphosphatase; Edetic Acid; Esterases; Gene Expression Regulation, Bacterial; Homoserine; Humans; Hydrolysis; Liver; Lung; Metals; Mice; Mice, Inbred ICR; Pseudomonas aeruginosa; Quorum Sensing

2008
Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis.
    Clinical science (London, England : 1979), 2008, Volume: 115, Issue:11

    Topics: 4-Butyrolactone; Apoptosis; B7-2 Antigen; Bacterial Proteins; Cells, Cultured; Coculture Techniques; Cytokines; Dendritic Cells; Homoserine; Humans; Immune Tolerance; Lymphocyte Activation; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Sepsis; T-Lymphocyte Subsets; Th2 Cells

2008
Pseudomonas aeruginosa quorum-sensing signal molecules induce IL-8 production by human corneal epithelial cells.
    Eye & contact lens, 2008, Volume: 34, Issue:3

    Topics: 4-Butyrolactone; Bacterial Proteins; Cell Line; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Homoserine; Humans; Interleukin-8; Pseudomonas aeruginosa; Quorum Sensing; Signal Transduction

2008
Bacterial quorum sensing: a new target for anti-infective immunotherapy.
    Expert opinion on biological therapy, 2008, Volume: 8, Issue:6

    Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Antibodies, Monoclonal; Antibody Specificity; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Vaccines; Drug Design; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Homoserine; Humans; Immunization, Passive; Immunotherapy; Immunotherapy, Active; Peptides, Cyclic; Quorum Sensing; Virulence

2008
Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule.
    Science (New York, N.Y.), 2008, Jul-11, Volume: 321, Issue:5886

    Topics: 4-Butyrolactone; Adult; Animals; Cyclic AMP Response Element-Binding Protein; Cystic Fibrosis; Female; Gene Expression Regulation; Homoserine; Humans; I-kappa B Kinase; I-kappa B Proteins; Immunity, Innate; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Toll-Like Receptors; Transcription Factor RelA

2008
A bacterial small molecule undermining immune response signaling.
    Chembiochem : a European journal of chemical biology, 2008, Nov-03, Volume: 9, Issue:16

    Topics: 4-Butyrolactone; Gene Expression Regulation; Homoserine; Humans; Immunity, Innate; NF-kappa B; Pseudomonas aeruginosa; Signal Transduction

2008
The junctional integrity of epithelial cells is modulated by Pseudomonas aeruginosa quorum sensing molecule through phosphorylation-dependent mechanisms.
    Experimental cell research, 2009, Jan-15, Volume: 315, Issue:2

    Topics: 4-Butyrolactone; beta Catenin; Caco-2 Cells; Cadherins; Cytoplasm; Epithelial Cells; Genistein; Homoserine; Humans; Intercellular Junctions; Membrane Proteins; Occludin; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Pseudomonas aeruginosa; Quorum Sensing; Staurosporine; Zonula Occludens-1 Protein

2009
Pseudomonas aeruginosa quorum-sensing signal molecules interfere with dendritic cell-induced T-cell proliferation.
    FEMS immunology and medical microbiology, 2009, Volume: 55, Issue:3

    Topics: 4-Butyrolactone; Animals; Cell Proliferation; Dendritic Cells; Homoserine; Immunologic Factors; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Quinolones; T-Lymphocytes

2009
Structural understanding of quorum-sensing inhibitors by molecular modeling study in Pseudomonas aeruginosa.
    Applied microbiology and biotechnology, 2009, Volume: 83, Issue:6

    Topics: 4-Butyrolactone; Anti-Bacterial Agents; Bacterial Proteins; Computer Simulation; Homoserine; Molecular Structure; Protein Binding; Pseudomonas aeruginosa; Quorum Sensing; Trans-Activators

2009
Influence of Pseudomonas aeruginosa quorum sensing signal molecule N-(3-oxododecanoyl) homoserine lactone on mast cells.
    Medical microbiology and immunology, 2009, Volume: 198, Issue:2

    Topics: 4-Butyrolactone; Animals; Apoptosis; Calcium; Cell Degranulation; Cell Line; Cell Proliferation; Cell Survival; Histamine; Homoserine; Interleukin-6; Mast Cells; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Virulence

2009
Pseudomonas aeruginosa Las quorum sensing autoinducer suppresses growth and biofilm production in Legionella species.
    Microbiology (Reading, England), 2009, Volume: 155, Issue:Pt 6

    Topics: 4-Butyrolactone; Biofilms; Genes, Bacterial; Homoserine; Legionella pneumophila; Pseudomonas aeruginosa; Quorum Sensing; Reverse Transcriptase Polymerase Chain Reaction; RNA, Bacterial; Virulence; Virulence Factors; Water Microbiology

2009
Microbial quorum-sensing molecules induce acrosome loss and cell death in human spermatozoa.
    Infection and immunity, 2009, Volume: 77, Issue:11

    Topics: 4-Butyrolactone; Acrosome; Apoptosis; Candida albicans; Cell Membrane; Cells, Cultured; Dendritic Cells; DNA Fragmentation; Farnesol; Flow Cytometry; Homoserine; Humans; Infertility, Male; Male; Microscopy, Fluorescence; Necrosis; Pseudomonas aeruginosa; Quorum Sensing; Sperm Motility; Spermatozoa

2009
Quorum-quenching acylase reduces the virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans infection model.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Amidohydrolases; Animals; Caenorhabditis elegans; Disease Models, Animal; Homoserine; Hydrogen Cyanide; Pseudomonas aeruginosa; Quorum Sensing; Virulence

2009
Role of PvdQ in Pseudomonas aeruginosa virulence under iron-limiting conditions.
    Microbiology (Reading, England), 2010, Volume: 156, Issue:Pt 1

    Topics: 4-Butyrolactone; Amidohydrolases; Animals; Bacterial Proteins; Biofilms; Caenorhabditis elegans; Gene Deletion; Gene Expression Regulation, Bacterial; Homoserine; Iron; Oligopeptides; Pseudomonas aeruginosa; Solanum tuberosum; Virulence

2010
Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin.
    The Biochemical journal, 2010, Jan-27, Volume: 426, Issue:1

    Topics: 4-Butyrolactone; Aryldialkylphosphatase; Biological Transport; Blotting, Western; Calcimycin; Calcium; Cell Line; Cell Survival; Down-Regulation; Enzyme Activation; Homoserine; Humans; Oxidative Stress; Pseudomonas aeruginosa; Pyocyanine; Quorum Sensing; RNA, Small Interfering; Virulence

2010
Pseudomonas signal molecule 3-oxo-C12-homoserine lactone interferes with binding of rosiglitazone to human PPARgamma.
    Microbes and infection, 2010, Volume: 12, Issue:3

    Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Homoserine; Humans; PPAR gamma; Protein Binding; Pseudomonas aeruginosa; Rosiglitazone; Thiazolidinediones

2010
Biofilm-induced modifications in the proteome of Pseudomonas aeruginosa planktonic cells.
    Biochimica et biophysica acta, 2010, Volume: 1804, Issue:4

    Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; 4-Butyrolactone; Alcohol Oxidoreductases; Bacterial Proteins; Biofilms; Bioreactors; Gene Expression; Homoserine; Oxidative Stress; Plankton; Proteome; Pseudomonas aeruginosa; Quorum Sensing

2010
Dynamic regulation of N-acyl-homoserine lactone production and degradation in Pseudomonas putida IsoF.
    FEMS microbiology ecology, 2010, Volume: 72, Issue:1

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Chromatography, Liquid; Feedback, Physiological; Homoserine; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Models, Biological; Pseudomonas putida; Quorum Sensing; Sequence Analysis, DNA

2010
Analysis of quorum sensing-dependent virulence factor production and its relationship with antimicrobial susceptibility in Pseudomonas aeruginosa respiratory isolates.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2010, Volume: 16, Issue:12

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Bacterial Proteins; Biofilms; Drug Resistance, Multiple, Bacterial; Endopeptidases; Gene Expression Regulation, Bacterial; Homoserine; Humans; Ligases; Metalloendopeptidases; Polymerase Chain Reaction; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Respiratory Tract Infections; Signal Transduction; Trans-Activators; Transcription Factors; Virulence Factors

2010
Pseudomonas aeruginosa pvdQ gene prevents Caco-2 cells from obstruction of quorum-sensing signal.
    Current microbiology, 2011, Volume: 62, Issue:1

    Topics: 4-Butyrolactone; Apoptosis; Bacterial Proteins; Caco-2 Cells; Epithelial Cells; Homoserine; Humans; Pseudomonas aeruginosa; Quorum Sensing

2011
Human transcriptome analysis reveals a potential role for active transport in the metabolism of Pseudomonas aeruginosa autoinducers.
    Microbes and infection, 2010, Volume: 12, Issue:12-13

    Topics: 4-Butyrolactone; Animals; Biological Transport, Active; Cells, Cultured; Cytoplasm; Epithelial Cells; Gene Expression Profiling; Homoserine; Humans; Metabolic Networks and Pathways; Mice; Microarray Analysis; Pseudomonas aeruginosa; Time Factors; Up-Regulation

2010
The plant pathogen Pseudomonas fuscovaginae contains two conserved quorum sensing systems involved in virulence and negatively regulated by RsaL and the novel regulator RsaM.
    Environmental microbiology, 2011, Volume: 13, Issue:1

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Cloning, Molecular; Gene Expression Regulation, Bacterial; Gene Knockout Techniques; Homoserine; Molecular Sequence Data; Mutation; Oryza; Plant Diseases; Pseudomonas; Quorum Sensing; Repressor Proteins; Substrate Specificity; Virulence

2011
Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples.
    Methods in molecular biology (Clifton, N.J.), 2011, Volume: 692

    Topics: 4-Butyrolactone; Biofilms; Chemical Fractionation; Chromatography, Liquid; Dimerization; Homoserine; Mass Spectrometry; Microscopy, Confocal; Pseudomonas aeruginosa; Reproducibility of Results

2011
Modulation of mammalian cell processes by bacterial quorum sensing molecules.
    Methods in molecular biology (Clifton, N.J.), 2011, Volume: 692

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Apoptosis; Bacteria; Blotting, Western; Cell Line; Homoserine; Humans; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Poly(ADP-ribose) Polymerases; Protein Kinase C-delta; Quorum Sensing; Signal Transduction

2011
Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model.
    Cellular microbiology, 2011, Volume: 13, Issue:3

    Topics: 4-Butyrolactone; Coculture Techniques; Epithelial Cells; Flow Cytometry; Homoserine; Humans; Intercellular Adhesion Molecule-1; Lung; Macrophages; Microscopy, Confocal; Pseudomonas aeruginosa; Pulmonary Alveoli; Quorum Sensing; Respiratory Mucosa; Signal Transduction; U937 Cells

2011
Controlling the contents of microdroplets by exploiting the permeability of PDMS.
    Lab on a chip, 2011, Mar-21, Volume: 11, Issue:6

    Topics: 4-Butyrolactone; Crystallization; Dimethylpolysiloxanes; Escherichia coli; Green Fluorescent Proteins; Homoserine; Microfluidic Analytical Techniques; Microscopy, Fluorescence; Permeability; Quorum Sensing

2011
The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.
    PloS one, 2011, Jan-31, Volume: 6, Issue:1

    Topics: 4-Butyrolactone; Calcium; Cystic Fibrosis; Cytokines; Epithelial Cells; Homoserine; Humans; Inflammation; Lactones; Pseudomonas aeruginosa; Respiratory System

2011
Electrochemical detection of quorum sensing signaling molecules by dual signal confirmation at microelectrode arrays.
    Analytical chemistry, 2011, Mar-15, Volume: 83, Issue:6

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Agrobacterium tumefaciens; Aminophenols; beta-Galactosidase; Biomimetic Materials; Biosensing Techniques; Culture Media, Conditioned; Electrochemistry; Galactosides; Gold; Homoserine; Hydrolysis; Limit of Detection; Microelectrodes; Pseudomonas aeruginosa; Quorum Sensing; Saliva; Time Factors

2011
A multitask biosensor for micro-volumetric detection of N-3-oxo-dodecanoyl-homoserine lactone quorum sensing signal.
    Biosensors & bioelectronics, 2011, Apr-15, Volume: 26, Issue:8

    Topics: 4-Butyrolactone; Biosensing Techniques; Cystic Fibrosis; High-Throughput Screening Assays; Homoserine; Humans; Pseudomonas aeruginosa; Quorum Sensing; Sputum

2011
PA0305 of Pseudomonas aeruginosa is a quorum quenching acylhomoserine lactone acylase belonging to the Ntn hydrolase superfamily.
    Microbiology (Reading, England), 2011, Volume: 157, Issue:Pt 7

    Topics: 4-Butyrolactone; Amidohydrolases; Animals; Caenorhabditis elegans; Carboxylic Ester Hydrolases; Cloning, Molecular; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Genome, Bacterial; Homoserine; Lactones; Penicillin Amidase; Protein Processing, Post-Translational; Pseudomonas aeruginosa; Quorum Sensing; Sequence Deletion; Virulence Factors

2011
The Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl) homoserine lactone can accelerate cutaneous wound healing through myofibroblast differentiation in rats.
    FEMS immunology and medical microbiology, 2011, Volume: 62, Issue:2

    Topics: 4-Butyrolactone; Animals; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Disease Models, Animal; Gene Expression; Histocytochemistry; Homoserine; Inflammation; Male; Myofibroblasts; Neutrophils; Pseudomonas aeruginosa; Rats; Rats, Sprague-Dawley; Up-Regulation; Wound Healing; Wounds and Injuries

2011
Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone.
    Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9

    Topics: 4-Butyrolactone; Animals; Aza Compounds; Bacterial Proteins; Cell Proliferation; Homoserine; Humans; Immunosuppressive Agents; Jurkat Cells; Leukocytes; Luminescent Measurements; Mice; Pseudomonas aeruginosa; Quorum Sensing; Structure-Activity Relationship; Trans-Activators

2011
The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1.
    Microbiology (Reading, England), 2011, Volume: 157, Issue:Pt 7

    Topics: 4-Butyrolactone; Bacterial Proteins; Combretum; Flavanones; Flavonoids; Gene Expression Regulation, Bacterial; Homoserine; Ligases; Pancreatic Elastase; Plant Preparations; Polymerase Chain Reaction; Pseudomonas aeruginosa; Pyocyanine; Quorum Sensing; Sequence Deletion; Transcription Factors; Virulence Factors

2011
OdDHL inhibits T cell subset differentiation and delays diabetes onset in NOD mice.
    Clinical and vaccine immunology : CVI, 2011, Volume: 18, Issue:8

    Topics: 4-Butyrolactone; Animals; Autoimmune Diseases; Cell Differentiation; Cell Proliferation; Diabetes Mellitus, Type 1; Homoserine; Immunologic Factors; Mice; Mice, Inbred NOD; Pseudomonas aeruginosa; T-Lymphocyte Subsets

2011
Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:11

    Topics: 4-Butyrolactone; Aorta; Apoptosis; Aryldialkylphosphatase; Cells, Cultured; Endothelium, Vascular; Gene Expression Regulation; Homoserine; Humans; Lipoproteins, LDL; Oxidation-Reduction; Phospholipids; Quorum Sensing; RNA, Small Interfering; Stress, Physiological

2011
Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen.
    Molecular systems biology, 2011, Aug-16, Volume: 7

    Topics: 4-Butyrolactone; Anti-Bacterial Agents; Antibiosis; Bacterial Proteins; Biofilms; Biosensing Techniques; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Reporter; Green Fluorescent Proteins; Homoserine; Humans; Organisms, Genetically Modified; Plasmids; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocins; Quorum Sensing; Recombinant Fusion Proteins; Synthetic Biology

2011
Microbial spy games and host response: roles of a Pseudomonas aeruginosa small molecule in communication with other species.
    PLoS pathogens, 2011, Volume: 7, Issue:11

    Topics: 4-Butyrolactone; Candida albicans; Homoserine; Host-Pathogen Interactions; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Staphylococcus aureus

2011
Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia.
    Cellular microbiology, 2012, Volume: 14, Issue:5

    Topics: 4-Butyrolactone; Apoptosis; Biofilms; Cell Line; Endoplasmic Reticulum; Epithelial Cells; Homoserine; Humans; Mitochondrial Membranes; Pseudomonas aeruginosa; Time Factors

2012
2,5-Piperazinedione inhibits quorum sensing-dependent factor production in Pseudomonas aeruginosa PAO1.
    Journal of basic microbiology, 2012, Volume: 52, Issue:6

    Topics: 4-Butyrolactone; Animals; Bacterial Proteins; Caenorhabditis elegans; Homoserine; Piperazines; Pseudomonas aeruginosa; Pyocyanine; Quorum Sensing; Repressor Proteins; Trans-Activators; Virulence Factors

2012
Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1).
    Immunobiology, 2013, Volume: 218, Issue:2

    Topics: 4-Butyrolactone; Actins; Biofilms; Cells, Cultured; Chemotaxis; Homoserine; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Microfilament Proteins; Neutrophils; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pseudomonas aeruginosa; Pseudomonas Infections; Pyridines; Quorum Sensing

2013
Regulation on expression of toll-like receptors on monocytes after stimulation with the 3-o-C12-HSL molecule from Pseudomonas aeruginosa.
    Current microbiology, 2012, Volume: 65, Issue:4

    Topics: 4-Butyrolactone; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation; Homoserine; Interleukin-12; Monocytes; Pseudomonas aeruginosa; RNA, Messenger; Toll-Like Receptors

2012
Cholinergic brush cells in the trachea mediate respiratory responses to quorum sensing molecules.
    Life sciences, 2012, Nov-27, Volume: 91, Issue:21-22

    Topics: 4-Butyrolactone; Animals; Homoserine; Host-Pathogen Interactions; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotinic Antagonists; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Receptors, Nicotinic; Respiration; Respiratory Mucosa; Trachea

2012
The Pseudomonas aeruginosa quorum sensing signal molecule N-(3-oxododecanoyl) homoserine lactone enhances keratinocyte migration and induces Mmp13 gene expression in vitro.
    Biochemical and biophysical research communications, 2012, Oct-19, Volume: 427, Issue:2

    Topics: 4-Butyrolactone; Animals; Cell Culture Techniques; Cell Line; Cell Movement; Collagen Type I; Collagen Type I, alpha 1 Chain; Gene Expression; Homoserine; Keratinocytes; Matrix Metalloproteinase 13; Pseudomonas aeruginosa; Quorum Sensing; Rats; Re-Epithelialization; Signal Transduction; Transcription Factor AP-1

2012
Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics.
    Organic & biomolecular chemistry, 2012, Nov-14, Volume: 10, Issue:42

    Topics: 4-Butyrolactone; Homoserine; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Small Molecule Libraries; Virulence Factors

2012
The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration.
    PLoS pathogens, 2012, Volume: 8, Issue:10

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Biofilms; Caco-2 Cells; cdc42 GTP-Binding Protein; Cell Line; Cell Movement; Epithelial Cells; Homoserine; Humans; Phosphorylation; Pseudomonas aeruginosa; Quorum Sensing; rac1 GTP-Binding Protein; ras GTPase-Activating Proteins; Signal Transduction; Virulence Factors

2012
A widely conserved molecular switch controls quorum sensing and symbiosis island transfer in Mesorhizobium loti through expression of a novel antiactivator.
    Molecular microbiology, 2013, Volume: 87, Issue:1

    Topics: 4-Butyrolactone; Amino Acid Sequence; Bacterial Proteins; Conjugation, Genetic; Gene Expression Regulation, Bacterial; Gene Transfer, Horizontal; Genomic Islands; Homoserine; Lotus; Mesorhizobium; Nitrogen Fixation; Plasmids; Promoter Regions, Genetic; Quorum Sensing; RNA, Messenger; Symbiosis; Transcription Factors; Transcription, Genetic; Transcriptional Activation

2013
Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.
    Chemical communications (Cambridge, England), 2013, Feb-21, Volume: 49, Issue:15

    Topics: 4-Butyrolactone; Animals; Bone Marrow Cells; Endoplasmic Reticulum Stress; Homoserine; Immunomodulation; Macrophages; Mice; NF-kappa B; Oxidation-Reduction; Poly(ADP-ribose) Polymerases; Pseudomonas aeruginosa; Quorum Sensing

2013
Neutrophil-derived tumor necrosis factor-α contributes to acute wound healing promoted by N-(3-oxododecanoyl)-L-homoserine lactone from Pseudomonas aeruginosa.
    Journal of dermatological science, 2013, Volume: 70, Issue:2

    Topics: 4-Butyrolactone; Animals; Antibodies, Anti-Idiotypic; Cell Proliferation; Disease Models, Animal; Epidermis; Homoserine; Male; Neovascularization, Physiologic; Neutrophils; Pseudomonas aeruginosa; Pseudomonas Infections; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Wound Healing

2013
Intra-species bacterial quorum sensing studied at single cell level in a double droplet trapping system.
    International journal of molecular sciences, 2013, May-21, Volume: 14, Issue:5

    Topics: 4-Butyrolactone; Bacterial Proteins; Escherichia coli; Green Fluorescent Proteins; Homoserine; Microfluidic Analytical Techniques; Microscopy, Fluorescence; Promoter Regions, Genetic; Quorum Sensing; Single-Cell Analysis; Trans-Activators; Transformation, Genetic

2013
Role of PON2 in innate immune response in an acute infection model.
    Molecular genetics and metabolism, 2013, Volume: 110, Issue:3

    Topics: 4-Butyrolactone; Animals; Antioxidants; Aryldialkylphosphatase; Homoserine; Immunity, Innate; Inflammation Mediators; Macrophages; Male; Mice; Mice, Knockout; Oxidative Stress; Phagocytosis; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Reactive Oxygen Species

2013
Tailor-made LasR agonists modulate quorum sensing in Pseudomonas aeruginosa.
    Organic & biomolecular chemistry, 2013, Nov-07, Volume: 11, Issue:41

    Topics: 4-Butyrolactone; Bacterial Proteins; Dose-Response Relationship, Drug; Homoserine; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Pseudomonas aeruginosa; Quorum Sensing; Structure-Activity Relationship; Trans-Activators

2013
Cis-2-dodecenoic acid signal modulates virulence of Pseudomonas aeruginosa through interference with quorum sensing systems and T3SS.
    BMC microbiology, 2013, Oct-18, Volume: 13

    Topics: 4-Butyrolactone; Animals; Antibiosis; Bacterial Secretion Systems; Biofilms; Burkholderia cenocepacia; Disease Models, Animal; Epithelial Cells; Fatty Acids, Monounsaturated; Gene Expression Profiling; HeLa Cells; Homoserine; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Quorum Sensing; Signal Transduction; Virulence; Virulence Factors; Zebrafish

2013
Role of Pseudomonas aeruginosa quorum sensing (QS) molecules on the viability and cytokine profile of human mesenchymal stem cells.
    Virulence, 2014, Feb-15, Volume: 5, Issue:2

    Topics: 4-Butyrolactone; 4-Quinolones; Apoptosis; Cell Survival; Cells, Cultured; Cytokines; Flow Cytometry; Homoserine; Humans; Mesenchymal Stem Cells; Pseudomonas aeruginosa; Quorum Sensing

2014
Interkingdom signaling and its consequences for human health.
    Virulence, 2014, Feb-15, Volume: 5, Issue:2

    Topics: 4-Butyrolactone; 4-Quinolones; Apoptosis; Cytokines; Homoserine; Humans; Mesenchymal Stem Cells; Pseudomonas aeruginosa; Quorum Sensing

2014
Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation.
    American journal of physiology. Cell physiology, 2014, Jul-15, Volume: 307, Issue:2

    Topics: 4-Butyrolactone; Apoptosis; Caco-2 Cells; Caspase 3; Epithelial Cells; Gene Expression Regulation; Homoserine; Humans; Intestinal Mucosa; Mucin-3; Phosphorylation; Proto-Oncogene Proteins c-akt

2014
Cellular effects of bacterial N-3-Oxo-dodecanoyl-L-Homoserine lactone on the sponge Suberites domuncula (Olivi, 1792): insights into an intimate inter-kingdom dialogue.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: 4-Butyrolactone; Animals; Apoptosis; Bacteria; Endocytosis; Gene Expression Regulation; Homoserine; Immunity, Innate; Membrane Proteins; Porifera; RNA, Messenger; Symbiosis

2014
Pantoea sp. isolated from tropical fresh water exhibiting N-acyl homoserine lactone production.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: 4-Butyrolactone; Base Sequence; Chromobacterium; Escherichia coli; Fresh Water; Homoserine; Malaysia; Molecular Sequence Data; Pantoea; Quorum Sensing; RNA, Ribosomal, 16S; Sequence Analysis, RNA; Sequence Homology; Tandem Mass Spectrometry; Tropical Climate

2014
Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR.
    Organic & biomolecular chemistry, 2015, Feb-07, Volume: 13, Issue:5

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Bacterial Proteins; Homoserine; Hydrogen Bonding; Ligands; Pseudomonas aeruginosa; Quorum Sensing; Trans-Activators

2015
Paraoxonase 2 serves a proapopotic function in mouse and human cells in response to the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-homoserine lactone.
    The Journal of biological chemistry, 2015, Mar-13, Volume: 290, Issue:11

    Topics: 4-Butyrolactone; Animals; Apoptosis; Aryldialkylphosphatase; Cells, Cultured; HEK293 Cells; Homoserine; Host-Pathogen Interactions; Humans; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing

2015
Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone.
    Bioscience, biotechnology, and biochemistry, 2015, Volume: 79, Issue:6

    Topics: 4-Butyrolactone; Caco-2 Cells; Cell Death; Cell Differentiation; Enzyme Activation; Homoserine; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mucin-3; Up-Regulation

2015
Immunization with 3-oxododecanoyl-L-homoserine lactone-r-PcrV conjugate enhances survival of mice against lethal burn infections caused by Pseudomonas aeruginosa.
    Bosnian journal of basic medical sciences, 2015, May-25, Volume: 15, Issue:2

    Topics: 4-Butyrolactone; Animals; Antibodies, Bacterial; Antigens, Bacterial; Bacterial Toxins; Burns; Disease Models, Animal; Female; Homoserine; Immunity, Humoral; Immunization; Liver; Mice; Mice, Inbred BALB C; Pore Forming Cytotoxic Proteins; Pseudomonas aeruginosa; Pseudomonas Infections; Skin; Spleen; Survival Rate; Vaccines, Conjugate

2015
Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitors.
    Bioorganic & medicinal chemistry letters, 2015, Aug-01, Volume: 25, Issue:15

    Topics: 4-Butyrolactone; Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Homoserine; Humans; Molecular Docking Simulation; Pseudomonas aeruginosa; Pseudomonas Infections; Pyrones; Quorum Sensing; Structure-Activity Relationship; Trans-Activators

2015
Pseudomonas aeruginosa quorum-sensing signaling molecule N-3-oxododecanoyl homoserine lactone induces matrix metalloproteinase 9 expression via the AP1 pathway in rat fibroblasts.
    Bioscience, biotechnology, and biochemistry, 2015, Volume: 79, Issue:10

    Topics: 4-Butyrolactone; Abietanes; Animals; Cell Line; Cell Nucleus; Fibroblasts; Gene Expression Regulation; Homoserine; Matrix Metalloproteinase 9; Promoter Regions, Genetic; Protein Transport; Proto-Oncogene Proteins c-fos; Pseudomonas aeruginosa; Quorum Sensing; Rats; Signal Transduction; Transcription Factor AP-1

2015
Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells.
    Infection and immunity, 2015, Volume: 83, Issue:10

    Topics: 4-Butyrolactone; HLA-G Antigens; Homoserine; Humans; Interleukin-10; Monocytes; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; T-Lymphocytes; U937 Cells; Up-Regulation

2015
Promotion of acute-phase skin wound healing by Pseudomonas aeruginosa C
    International wound journal, 2016, Volume: 13, Issue:6

    Topics: 4-Butyrolactone; Acute Disease; Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Female; Homoserine; Immunohistochemistry; Neutrophils; Pseudomonas aeruginosa; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tumor Necrosis Factor-alpha; Wound Healing; Wounds and Injuries

2016
N-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins.
    Oncotarget, 2016, Feb-02, Volume: 7, Issue:5

    Topics: 4-Butyrolactone; Animals; Apoptosis; Aryldialkylphosphatase; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Female; Flow Cytometry; Fluorescent Antibody Technique; Homoserine; Humans; Immunoenzyme Techniques; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2016
Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells.
    Pathogens and disease, 2016, Volume: 74, Issue:3

    Topics: 4-Butyrolactone; Biofilms; Cell Line, Tumor; Chemotaxis; HL-60 Cells; Homoserine; Humans; Lipid Droplets; Macrophages; Neutrophils; Phagocytosis; Platelet Glycoprotein GPIb-IX Complex; Quorum Sensing; Receptors, G-Protein-Coupled; U937 Cells

2016
Orthogonal intercellular signaling for programmed spatial behavior.
    Molecular systems biology, 2016, Jan-25, Volume: 12, Issue:1

    Topics: 4-Butyrolactone; Cell Communication; Homoserine; Models, Genetic; Promoter Regions, Genetic; Quorum Sensing; Signal Transduction; Systems Biology

2016
Pseudomonas aeruginosa N-3-oxo-dodecanoyl-homoserine Lactone Elicits Changes in Cell Volume, Morphology, and AQP9 Characteristics in Macrophages.
    Frontiers in cellular and infection microbiology, 2016, Volume: 6

    Topics: 4-Butyrolactone; Aquaporins; Biofilms; Cell Shape; Cell Size; Cells, Cultured; Homoserine; Host-Pathogen Interactions; Humans; Immunity, Innate; Macrophages; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; RNA, Messenger; Signal Transduction; Virulence Factors; Water

2016
Paraoxonase 2 modulates a proapoptotic function in LS174T cells in response to quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone.
    Scientific reports, 2016, 07-01, Volume: 6

    Topics: 4-Butyrolactone; Acetylcysteine; Apoptosis; Aryldialkylphosphatase; beta-Cyclodextrins; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Homoserine; Humans; Microscopy, Electron, Transmission; Mitochondria; Mucin-2; Quorum Sensing

2016
The effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors of Pseudomonas aeruginosa.
    Journal of applied microbiology, 2017, Volume: 122, Issue:3

    Topics: 4-Butyrolactone; Arctium; Biofilms; Homoserine; Pancreatic Elastase; Plant Extracts; Plant Leaves; Pseudomonas aeruginosa; Pyocyanine; Quorum Sensing; Virulence; Virulence Factors

2017
The bacterial quorum-sensing molecule, N-3-oxo-dodecanoyl-L-homoserine lactone, inhibits mediator release and chemotaxis of murine mast cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017, Volume: 66, Issue:3

    Topics: 4-Butyrolactone; Animals; Apoptosis; Cells, Cultured; Chemotaxis; Homoserine; Interleukin-6; Lipopolysaccharides; Male; Mast Cells; Mice; Mice, Inbred BALB C; Passive Cutaneous Anaphylaxis; Pseudomonas aeruginosa; Quorum Sensing; Tumor Necrosis Factor-alpha

2017
Exposure of airway epithelial cells to Pseudomonas aeruginosa biofilm-derived quorum sensing molecules decrease the activity of the anti-oxidant response element bound by NRF2.
    Biochemical and biophysical research communications, 2017, 02-05, Volume: 483, Issue:2

    Topics: 4-Butyrolactone; Antioxidant Response Elements; Biofilms; Cell Line; Cystic Fibrosis; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Homoserine; Humans; Interleukin-8; Lung; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing

2017
Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes.
    Biofouling, 2017, Volume: 33, Issue:2

    Topics: 4-Butyrolactone; Anti-Bacterial Agents; Furans; Homoserine; Microbial Sensitivity Tests; Molecular Docking Simulation; Phenotype; Pseudomonas aeruginosa; Quorum Sensing; Vinyl Compounds; Virulence Factors

2017
Characterization of the multiple molecular mechanisms underlying RsaL control of phenazine-1-carboxylic acid biosynthesis in the rhizosphere bacterium Pseudomonas aeruginosa PA1201.
    Molecular microbiology, 2017, Volume: 104, Issue:6

    Topics: 4-Butyrolactone; Bacteria; Bacterial Proteins; Gene Expression Regulation, Bacterial; Homoserine; Phenazines; Promoter Regions, Genetic; Pseudomonas aeruginosa; Quorum Sensing; Repressor Proteins; Rhizosphere

2017
Quorum sensing network in clinical strains of A. baumannii: AidA is a new quorum quenching enzyme.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: 4-Butyrolactone; Acinetobacter baumannii; Bacterial Proteins; Cross Infection; Down-Regulation; Escherichia coli; Genes, Bacterial; Homoserine; Quorum Sensing

2017
Structure based virtual screening for identification of potential quorum sensing inhibitors against LasR master regulator in Pseudomonas aeruginosa.
    Microbial pathogenesis, 2017, Volume: 107

    Topics: 4-Butyrolactone; Anti-Bacterial Agents; Bacterial Proteins; Chemical Phenomena; Drug Discovery; Drug Evaluation, Preclinical; Homoserine; Hydrogen Bonding; Molecular Conformation; Molecular Docking Simulation; Pseudomonas aeruginosa; Quorum Sensing; Trans-Activators; Transcription Factors; User-Computer Interface; Virulence Factors

2017
Expression of toll-like receptors in T lymphocytes stimulated with N-(3-oxododecanoyl)-L-homoserine lactone from Pseudomonas aeruginosa.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2017, Volume: 125, Issue:6

    Topics: 4-Butyrolactone; Cell Proliferation; Cells, Cultured; Gene Expression; Homoserine; Humans; T-Lymphocytes; Toll-Like Receptors; Tumor Necrosis Factor-alpha

2017
The multi-output incoherent feedforward loop constituted by the transcriptional regulators LasR and RsaL confers robustness to a subset of quorum sensing genes in Pseudomonas aeruginosa.
    Molecular bioSystems, 2017, Jun-01, Volume: 13, Issue:6

    Topics: 4-Butyrolactone; Bacterial Proteins; Gene Expression Regulation; Homoserine; Pseudomonas aeruginosa; Quorum Sensing; Repressor Proteins; Trans-Activators

2017
Pseudomonas aeruginosa quorum-sensing response in the absence of functional LasR and LasI proteins: the case of strain 148, a virulent dolphin isolate.
    FEMS microbiology letters, 2017, 07-03, Volume: 364, Issue:12

    Topics: 4-Butyrolactone; Animals; Bacterial Proteins; Cyclic AMP Receptor Protein; Dolphins; Gene Expression Regulation, Bacterial; Glycolipids; Homoserine; Operon; Pseudomonas aeruginosa; Pyocyanine; Quorum Sensing; Trans-Activators; Transcription, Genetic; Virulence

2017
Quorum sensing molecules production by nosocomial and soil isolates Acinetobacter baumannii.
    Archives of microbiology, 2017, Volume: 199, Issue:10

    Topics: 4-Butyrolactone; Acinetobacter baumannii; Agrobacterium tumefaciens; Anti-Bacterial Agents; Biofilms; Biosensing Techniques; Chromatography, Thin Layer; Chromobacterium; Cross Infection; Homoserine; Lactones; Quorum Sensing; Soil Microbiology; Virulence Factors

2017
N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: 4-Butyrolactone; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Homoserine; Humans; Necrosis; Tumor Microenvironment

2017
Pseudomonas aeruginosa auto inducer3-oxo-C
    Microbial pathogenesis, 2017, Volume: 110

    Topics: 4-Butyrolactone; Antibiosis; Biofilms; Homoserine; Pseudomonas aeruginosa; Staphylococcus epidermidis

2017
N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts.
    Cellular microbiology, 2018, Volume: 20, Issue:1

    Topics: 4-Butyrolactone; Animals; Apoptosis; Caspase 3; Caspase 7; Caspase 9; Cell Line, Tumor; Cytochromes c; Fibroblasts; HCT116 Cells; Homoserine; Humans; Mice; Mice, Knockout; Microbial Interactions; Mitochondria; Mitochondrial Membranes; Pseudomonas aeruginosa; Quorum Sensing

2018
A novel screen-printed mast cell-based electrochemical sensor for detecting spoilage bacterial quorum signaling molecules (N-acyl-homoserine-lactones) in freshwater fish.
    Biosensors & bioelectronics, 2018, Apr-15, Volume: 102

    Topics: 4-Butyrolactone; Animals; Biosensing Techniques; Dielectric Spectroscopy; Fishes; Fresh Water; Graphite; Homoserine; Mast Cells; Nanotubes, Carbon; Pseudomonas aeruginosa; Quorum Sensing; Rats

2018
N-(3-oxododecanoyl)-l-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes: Its relation with intracellular Zn
    Chemico-biological interactions, 2018, Jan-25, Volume: 280

    Topics: 4-Butyrolactone; Animals; Apoptosis; Cells, Cultured; Glutathione; Homoserine; Lymphocytes; Male; Oxidative Stress; Quorum Sensing; Rats; Rats, Wistar; Sulfhydryl Compounds; Thymus Gland; Zinc

2018
Hyperpolarization by N-(3-oxododecanoyl)-l-homoserine-lactone, a quorum sensing molecule, in rat thymic lymphocytes.
    Chemico-biological interactions, 2018, Mar-01, Volume: 283

    Topics: 4-Butyrolactone; Animals; Calcium; Cell Polarity; Charybdotoxin; Flow Cytometry; Glyburide; Homoserine; KATP Channels; Lymphocytes; Permeability; Potassium; Potassium Channels, Voltage-Gated; Quinine; Quorum Sensing; Rats; Rats, Wistar; Thymocytes

2018
N-(3-oxododecanoyl)-l-homoserine lactone modulates mitochondrial function and suppresses proliferation in intestinal goblet cells.
    Life sciences, 2018, May-15, Volume: 201

    Topics: 4-Butyrolactone; Adenosine Triphosphate; Apoptosis; Aryldialkylphosphatase; Calcium; Cell Proliferation; Electron Transport; Goblet Cells; Homoserine; Humans; Intestines; Mitochondria; Quorum Sensing

2018
Stochastic Turing patterns in a synthetic bacterial population.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 06-26, Volume: 115, Issue:26

    Topics: 4-Butyrolactone; Bacterial Proteins; Binding, Competitive; Computer Simulation; Diffusion; Gene Expression Regulation, Bacterial; Genes, Reporter; Homoserine; Isopropyl Thiogalactoside; Ligases; Models, Biological; Morphogenesis; Promoter Regions, Genetic; Pseudomonas aeruginosa; Quorum Sensing; Recombinant Proteins; Stochastic Processes; Trans-Activators; Transcription Factors

2018
Pseudomonas aeruginosa quorum sensing molecule N-3-oxo-dodecanoyl-l-homoserine lactone activates human platelets through intracellular calcium-mediated ROS generation.
    International journal of medical microbiology : IJMM, 2018, Volume: 308, Issue:7

    Topics: 4-Butyrolactone; Blood Platelets; Calcium; Homoserine; Humans; Inositol 1,4,5-Trisphosphate Receptors; Platelet Activation; Pseudomonas aeruginosa; Quorum Sensing; Reactive Oxygen Species; Type C Phospholipases

2018
Caspase-1-dependent mechanism mediating the harmful impacts of the quorum-sensing molecule N-(3-oxo-dodecanoyl)-l-homoserine lactone on the intestinal cells.
    Journal of cellular physiology, 2019, Volume: 234, Issue:4

    Topics: 4-Butyrolactone; Aryldialkylphosphatase; Caspase 1; Caspase 3; Cell Line; Enzyme Activation; Goblet Cells; Homoserine; Humans; Inflammation Mediators; Mucins; Oxidative Stress; Pyroptosis; Quorum Sensing; Reactive Oxygen Species; Signal Transduction

2019
Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution.
    Nature microbiology, 2019, Volume: 4, Issue:1

    Topics: 4-Butyrolactone; Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line; Chlorocebus aethiops; COS Cells; HeLa Cells; Homoserine; Humans; Immune Evasion; Membrane Lipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; RAW 264.7 Cells; Receptors, Tumor Necrosis Factor, Type I

2019
Mechanism underlying N-(3-oxo-dodecanoyl)-L-homoserine lactone mediated intracellular calcium mobilization in human platelets.
    Blood cells, molecules & diseases, 2019, Volume: 79

    Topics: 4-Butyrolactone; Blood Platelets; Calcium; Calcium Signaling; Homoserine; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Virulence

2019
Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone triggers mitochondrial dysfunction and apoptosis in neutrophils through calcium signaling.
    Medical microbiology and immunology, 2019, Volume: 208, Issue:6

    Topics: 4-Butyrolactone; Apoptosis; Calcium Signaling; Healthy Volunteers; Homoserine; Humans; Mitochondria; Neutrophils; Pseudomonas aeruginosa

2019
Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction.
    Scientific reports, 2019, 08-15, Volume: 9, Issue:1

    Topics: 4-Butyrolactone; Apoptosis; Bronchi; Cell Line; Cell Respiration; DNA Damage; DNA, Mitochondrial; Epithelial Cells; Homoserine; Host-Pathogen Interactions; Humans; Metformin; Mitochondria; Models, Biological; Organelle Biogenesis; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Reactive Oxygen Species; Resveratrol

2019
Removal of toluene vapor in the absence and presence of a quorum-sensing molecule in a biotrickling filter and microbial composition shift.
    Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 2020, Volume: 55, Issue:3

    Topics: 4-Butyrolactone; Air Pollutants; Bacteria; Biodegradation, Environmental; Bioreactors; Filtration; Gases; Homoserine; Microbiota; Quorum Sensing; Toluene

2020
Genetic and Biochemical Diversity for N-acylhomoserine Lactone Biosynthesis in the Plant Pathogen Pectobacterium carotovorum subsp. carotovorum.
    Microbes and environments, 2019, Dec-27, Volume: 34, Issue:4

    Topics: 4-Butyrolactone; Acyl-Butyrolactones; Amino Acid Sequence; Bacterial Proteins; Genetic Variation; Homoserine; Pectobacterium carotovorum; Phylogeny; Plant Diseases; Quorum Sensing

2019
A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms.
    International journal of pharmaceutics, 2020, Mar-30, Volume: 578

    Topics: 4-Butyrolactone; Antifungal Agents; Biofilms; Candida albicans; Drug Delivery Systems; Drug Liberation; Fluconazole; Homoserine; Liposomes; Pseudomonas aeruginosa; Quorum Sensing

2020
Tarragon essential oil as a source of bioactive compounds with anti-quorum sensing and anti-proteolytic activity against Pseudomonas spp. isolated from fish - in vitro, in silico and in situ approaches.
    International journal of food microbiology, 2020, Oct-16, Volume: 331

    Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Artemisia; Computer Simulation; Fishes; Homoserine; Oils, Volatile; Proteolysis; Pseudomonas; Quorum Sensing

2020
The impaired quorum sensing response of Pseudomonas aeruginosa MexAB-OprM efflux pump overexpressing mutants is not due to non-physiological efflux of 3-oxo-C12-HSL.
    Environmental microbiology, 2020, Volume: 22, Issue:12

    Topics: 4-Butyrolactone; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Caprylates; Drug Resistance, Bacterial; Homoserine; Membrane Transport Proteins; Pseudomonas aeruginosa; Quinolones; Quorum Sensing

2020
N-(3-oxododecanoyl)-homoserine lactone regulates osteoblast apoptosis and differentiation by mediating intracellular calcium.
    Cellular signalling, 2020, Volume: 75

    Topics: 4-Butyrolactone; Animals; Calcium; Cell Differentiation; Cell Line; Homoserine; Mice; Osteoblasts; Periodontitis; Pseudomonas aeruginosa; Quorum Sensing

2020
Influence of Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone on human corneal epithelial cells.
    Experimental biology and medicine (Maywood, N.J.), 2021, Volume: 246, Issue:4

    Topics: 4-Butyrolactone; Cell Survival; Cytokines; Epithelial Cells; Epithelium, Corneal; Homoserine; Humans; Inflammation Mediators; Interleukin-8; NF-kappa B; Pseudomonas aeruginosa; Toll-Like Receptor 2; Toll-Like Receptor 4

2021
N-(3-oxododecanoyl)-l-homoserine lactone disrupts intestinal epithelial barrier through triggering apoptosis and collapsing extracellular matrix and tight junction.
    Journal of cellular physiology, 2021, Volume: 236, Issue:8

    Topics: 4-Butyrolactone; Animals; Apoptosis; Epithelial Cells; Extracellular Matrix; Homoserine; Intestinal Mucosa; Lactones; Mice; Pseudomonas aeruginosa; Tight Junction Proteins; Tight Junctions

2021
Autoinducer N-(3-oxododecanoyl)-l-homoserine lactone induces calcium and reactive oxygen species-mediated mitochondrial damage and apoptosis in blood platelets.
    Microbial pathogenesis, 2021, Volume: 154

    Topics: 4-Butyrolactone; Apoptosis; Blood Platelets; Calcium; Homoserine; Humans; Lactones; Pseudomonas aeruginosa; Reactive Oxygen Species

2021
An innovative role for luteolin as a natural quorum sensing inhibitor in Pseudomonas aeruginosa.
    Life sciences, 2021, Jun-01, Volume: 274

    Topics: 4-Butyrolactone; Bacterial Proteins; Biofilms; Gene Expression Regulation, Bacterial; Homoserine; Humans; Luteolin; Molecular Docking Simulation; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Trans-Activators; Virulence Factors

2021
N-(3-oxododecanoyl)-homoserine lactone disrupts intestinal barrier and induces systemic inflammation through perturbing gut microbiome in mice.
    The Science of the total environment, 2021, Jul-15, Volume: 778

    Topics: 4-Butyrolactone; Animals; Gastrointestinal Microbiome; Homoserine; Inflammation; Mice; Quorum Sensing

2021
Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection.
    Signal transduction and targeted therapy, 2021, 06-04, Volume: 6, Issue:1

    Topics: 4-Butyrolactone; Animals; Cell Nucleus; Cytoplasm; Homoserine; Host-Pathogen Interactions; Humans; Lipid Droplets; Mice; Neutrophils; Perilipin-2; PPAR gamma; Pseudomonas aeruginosa; Pseudomonas Infections; Receptors, G-Protein-Coupled; Tongue

2021
N-3-(oxododecanoyl)-L-homoserine lactone suppresses dendritic cell maturation by upregulating the long noncoding RNA NRIR.
    Journal of biosciences, 2021, Volume: 46

    Topics: 4-Butyrolactone; Case-Control Studies; Cell Differentiation; Dendritic Cells; Homoserine; Humans; Interleukin-6; Monocytes; Pseudomonas aeruginosa; Pseudomonas Infections; RNA, Long Noncoding

2021
N-3-oxododecanoyl homoserine lactone exacerbates endothelial cell death by inducing receptor-interacting protein kinase 1-dependent apoptosis.
    American journal of physiology. Cell physiology, 2021, 10-01, Volume: 321, Issue:4

    Topics: 4-Butyrolactone; Apoptosis; Caspase 3; Caspase 8; Cells, Cultured; Enzyme Activation; Homoserine; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction

2021
Study of the Dynamics of Biofilm Formation and Elastase Activity of Pseudomonas aeruginosa in the Presence of Dodecanoyl-Homoserine Lactone.
    Bulletin of experimental biology and medicine, 2021, Volume: 171, Issue:6

    Topics: 4-Butyrolactone; Bacterial Load; Bacterial Proteins; Biofilms; Culture Media; Dose-Response Relationship, Drug; Homoserine; Pancreatic Elastase; Pseudomonas aeruginosa; Quorum Sensing

2021
Virulence and biofilm inhibition of 3-methoxycinnamic acid against Agrobacterium tumefaciens.
    Journal of applied microbiology, 2022, Volume: 133, Issue:5

    Topics: 4-Butyrolactone; Agrobacterium tumefaciens; beta-Galactosidase; Biofilms; Gentian Violet; Molecular Docking Simulation; Pesticides; Phenols; Quorum Sensing

2022