protoporphyrin ix has been researched along with heme in 214 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (12.15) | 18.7374 |
| 1990's | 42 (19.63) | 18.2507 |
| 2000's | 62 (28.97) | 29.6817 |
| 2010's | 73 (34.11) | 24.3611 |
| 2020's | 11 (5.14) | 2.80 |
| Authors | Studies |
|---|---|
| Austin, RH; Vaz, WL; Vogel, H | 1 |
| Cheesman, MR; Harrison, PM; Kadir, FH; Moore, GR; Thomson, AJ; Yewdall, SJ | 1 |
| Kennedy, JC; Pottier, RH | 1 |
| Beri, R; Chandra, R; Kumar, V | 1 |
| Dawson, JH; Kadkhodayan, S; Sono, M; Zhuang, C | 1 |
| Cox, TM; Gardner, LC; Smith, SJ | 1 |
| Andersson, KK; Babcock, GT; Hooper, AB | 1 |
| Balla, G; Eaton, J; Jacob, HS; Muller-Eberhard, U; Vercellotti, GM | 1 |
| Cazzaro, S; Manno, M; Rezzadore, M | 1 |
| Brunori, M; Campanella, L; Faraoni, A; Santucci, R; Tranchida, G | 1 |
| Daniels-McQueen, S; Gaffield, L; Lin, JJ; Patino, MM; Thach, RE; Walden, WE | 1 |
| Brown, MR; MacIver, I; O'Reilly, T | 1 |
| Cutler, MG; Mair, J; Moore, MR | 1 |
| Ignarro, LJ; Wood, KS | 1 |
| Drummond, GS | 1 |
| Grab, LA; Ortiz de Montellano, PR; Swanson, BA | 1 |
| elDeib, MM; Parker, CD; White, AA | 1 |
| Ator, MA; David, SK; Ortiz de Montellano, PR; Tew, D | 1 |
| Dailey, HA; Fadigan, A | 1 |
| Arrol, S; Cutler, MG | 1 |
| Hronis, TS; Traugh, JA | 1 |
| Albani, J; Alpert, B | 1 |
| Louache, F; Pelicci, P; Rochant, H; Testa, U; Thomopoulos, P; Titeux, M | 1 |
| Ignarro, LJ; Wolin, MS; Wood, KS | 3 |
| Ignarro, LJ; Ohlstein, EH; Wood, KS | 1 |
| Kitchin, KT | 1 |
| Louache, F; Rochant, H; Testa, U; Thomopoulos, P; Titeux, M | 1 |
| Alexopoulos, J; Cummins, R; Kramer, S; Viljoen, DJ | 1 |
| Kulmacz, RJ; Lands, WE | 1 |
| Dreyer, U; Philo, JS; Schuster, TM | 1 |
| Hooper, AB; Hyzy, B; Lageson, J; Ruben, L | 1 |
| Fukui, S; Isobe, N; Kamihara, T; Nakamura, I; Nakamura, N | 1 |
| Ulvik, RJ | 1 |
| Novogrodsky, A; Rubin, AL; Stenzel, KH | 1 |
| Mathews, JM; Ortiz de Montellano, PR | 1 |
| Hayashi, N | 1 |
| Harada, K; Kim, Y; Ohmori, S; Tomokuni, K | 1 |
| Adler, J; Inokuchi, H; Yang, H | 1 |
| Hryhorenko, E; Morgan, J; Oseroff, AR; Paszkiewicz, G; Rittenhouse-Diakun, K; Van Leengoed, H; Whitaker, JE | 1 |
| Cordone, L; Cupane, A; Leone, M; Militello, V | 1 |
| Davey, C; Fenna, R; Zeng, J | 1 |
| Friedrich, J; Gafert, J; Parak, F | 1 |
| Bedwell, J; Bown, SG; MacRobert, AJ; Ravi, B; Regula, J | 1 |
| Bissbort, SH; Myburgh, S; Van Brummelen, R | 1 |
| Brunet, JE; Gratton, E; Jameson, DM; Vargas, V | 1 |
| Brunet, JE; Pulgar, M | 1 |
| Holland, J; Parsons, T; Smith, A; Williams, P; Wong, JC | 1 |
| Chottard, G; Gaspard, S; Mahy, JP; Mansuy, D | 1 |
| Foerster, J; Harteneck, C; Koesling, D; Malkewitz, J; Schultz, G | 1 |
| Immenschuh, S; Iwahara, S; Katz, N; Muller-Eberhard, U; Nell, C | 1 |
| Baek, HK; Kulmacz, RJ; Tsai, Al; Van Wart, HE; Wei, C | 1 |
| Hasan, AA; Holland, J; Smith, A; Williams, P | 1 |
| Riley, PA; Washbrook, R | 1 |
| Berg, K; Giercksky, KE; Kongshaug, M; Moan, J; Nesland, JM; Peng, Q; Warloe, T | 1 |
| Bakhtiar, R; Hop, CE; Leung, KH; Stearns, RA | 1 |
| Friebe, A; Koesling, D | 1 |
| Cannons, AC; Ming, LJ; Solomonson, LP; Wei, X | 1 |
| Berglund, A; De Rosa, MC | 1 |
| Brissette, J; Chen, N; Dotto, GP; Hasan, T; Maytin, E; Ortel, B | 1 |
| Burstyn, JN; Serfass, L | 1 |
| Aust, SD; Reading, NS | 1 |
| Kamboj, KK; Pandey, VC; Puri, SK; Srivastava, P | 1 |
| Basilico, N; Monti, D; Olliaro, P; Taramelli, D; Vodopivec, B | 1 |
| Afonso, S; Batlle, A; Vanore, G | 1 |
| Kleibeuker, JH; Sesink, AL; Termont, DS; Van der Meer, R | 1 |
| Birss, AJ; Silver, J; Smalley, JW | 1 |
| Egger, NG; Flores, P; Fossum, TW; Jacques, SL; Motamedi, M; Rastegar, S; Vaidyanathan, VV; van Der Breggen, EW | 1 |
| de Rooij, FW; Edixhoven, A; Hinnen, P; Siersema, PD; Terlouw, EM; Tilanus, HW; van Dekken, H; van Hillegersberg, R; Wilson, JH | 1 |
| Matthews, EK; Mesenhöller, M | 1 |
| Cox, CD; Drake, DR; Johnson, WT; Zerr, MA | 1 |
| Hunt, NH; Mashima, R; Richardson, DR; Salahifar, H; Stocker, R; Thomas, SR | 1 |
| Aime, S; Ascenzi, P; Baroni, S; Fasano, M; Vannini, A | 1 |
| Huang, TJ; Maines, MD; McCoubrey, WK | 1 |
| Braun, HP; Grimm, B; Kruse, E; Mishra, S; Mock, HP; Papenbrock, J; Petersmann, A; Schmidt, EK | 1 |
| Browne, C; Chen, JJ; Chin, G; Fleming, M; Fujiwara, Y; Han, AP; Leboulch, P; Lu, L; Orkin, SH; Yu, C | 1 |
| Colas, C; Kuo, JM; Ortiz de Montellano, PR | 1 |
| Inokuchi, H; Kanjo, N; Nakahigashi, K; Oeda, K | 1 |
| Cornah, JE; Pal Singh, D; Roper, JM; Smith, AG | 1 |
| Delepierre, M; Deniau, C; Kumar, V; Lecroisey, A; Létoffé, S; Simenel, C; Stojiljkovic, I; Wandersman, C; Wolff, N | 1 |
| Becker, EM; Greer, JM; Ponka, P; Richardson, DR | 1 |
| Andreoletti, P; Gagnon, J; Jaquinod, M; Jouve, HM; Sainz, G | 1 |
| Akerström, B; Allhorn, M; Lundqvist, K; Schmidtchen, A | 1 |
| Schmidt, P; Schramm, M; Schröder, H; Stasch, JP | 1 |
| DANIEL, JW; KELLEY, J; RUSCH, HP | 1 |
| Alderete, JF; Lehker, MW; Mundodi, V; Nguyen, J | 1 |
| Bailey-Dell, K; Krishnamurthy, P; Mercer, KE; Nakanishi, T; Ross, DD; Sarkadi, B; Schuetz, JD; Sorrentino, BP; Zhou, S | 1 |
| Cowan, JA; Yoon, T | 1 |
| Collaud, S; Juzeniene, A; Lange, N; Moan, J | 1 |
| Berezhna, S; Cao, W; Champion, PM; Demidov, AA; Georgiev, GY; Sage, JT; Sjodin, T; Wang, W; Ye, X | 1 |
| Degenhardt, B; Grimm, B; Hause, G; Koch, A; Lindemann, P; Papadopoulos, V | 1 |
| Brown, KA; Moody, PC; Raven, EL; Sharp, KH | 1 |
| Austin, CJ; Jamie, JF; Kosim-Satyaputra, P; Matin, A; Mizdrak, J; Parker, MW; Polekhina, G; Roberts, TH; Sirijovski, N; Truscott, RJ; Willows, RD | 1 |
| Beraud, JJ; Canaud, B; Cristol, JP; Descomps, B; Klouche, K; Morena, M | 1 |
| Bose, T; Chakraborti, AS; Roy, D; Sil, S | 1 |
| Aires-Barros, MR; Carvalho, AS; Neves-Petersen, MT; Petersen, SB; Pinho e Melo, E | 1 |
| Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F | 1 |
| Ferguson, SJ; Harvat, EM; Redfield, C; Stevens, JM | 1 |
| Buckpitt, AR; Cortopassi, GA; Lonnerdal, B; Morin, D; Napoli, E; Puccio, H; Reutenauer, L; Ristow, M; Schoenfeld, RA; Taroni, F; Wong, A; Zhan, S | 1 |
| Funabiki, T; Hitomi, Y; Mukai, H; Tanaka, T; Yoshimura, H | 1 |
| Carotti, A; Cavalli, A; Favia, AD; Masetti, M; Recanatini, M | 1 |
| Chen, Q; Hirsch, RE | 1 |
| Batlle, A; Casas, A; Fukuda, H | 1 |
| Birss, AJ; Potempa, J; Smalley, JW; Szmigielski, B | 1 |
| Abraham, NG; Ahmad, M; Chow, JL; Gupte, SA; Mingone, CJ; Wolin, MS | 1 |
| Dias, JS; Ferreira, GC; Goodfellow, BJ; Macedo, AL; Peterson, FC; Volkman, BF | 1 |
| Guo, M; Tong, Y | 1 |
| Domínguez, E; Fruk, L; Müller, J; Narváez, A; Niemeyer, CM; Weber, G | 1 |
| Alves, LS; Bozza, MT; Dutra, FF; Fernandez, PL; Figueiredo, RT; Graça-Souza, AV; Mourao-Sa, DS; Oliveira, MF; Oliveira, PL; Porto, BN | 1 |
| Alves, WA; Casella, L; da Costa Ferreira, AM; Dallacosta, C; Monzani, E | 1 |
| Abt, B; Al-Abdallah, Q; Bergmann, S; Brakhage, AA; Eisendle, M; Haas, H; Hortschansky, P; Kato, M; Kniemeyer, O; Schmidt, AD; Seeber, B; Thön, M; Werner, ER | 1 |
| Drepper, F; Haehnel, W; Lubitz, W; Monien, BH; Sommerhalter, M | 1 |
| Berridge, MV; Rish, KR; Sadikot, TN; Smith, A; Swartzlander, R | 1 |
| Arenas-Huertero, F; Ramón-Gallegos, E; Ruiz-Galindo, E | 1 |
| Ebert, B; Kemmner, W; Klamm, U; Macdonald, R; Moesta, KT; Rüttinger, S; Wan, K | 1 |
| Dailey, HA; Dailey, TA; Lanzilotta, WN; Medlock, AE; Ross, TA | 1 |
| Dörr, S; Hellwig, P; Ortolani, M; Schade, U | 1 |
| Androphy, R; Keane, P; Philpott, CC; Protchenko, O; Shakoury-Elizeh, M; Storey, J | 1 |
| Alawady, A; Beck, CF; Grimm, B; Meinecke, L; von Gromoff, ED | 1 |
| Ferreira, GC; Hunter, GA; Sampson, MP | 1 |
| Clubb, RT; Fadeev, EA; Pilpa, RM; Robson, SA; Villareal, VA | 1 |
| Azuma, M; Handa, H; Kabe, Y; Kondo, M; Kuramori, C; Yamaguchi, Y | 1 |
| Shimizu, T; Tanaka, A | 1 |
| Abt, B; Haas, H; Moussa, TA; Schrettl, M; Werner, ER; Yasmin, S | 1 |
| Delepelaire, P; Heuck, G; Lange, N; Létoffé, S; Wandersman, C | 1 |
| Afonso, SG; Batlle, A; Buzaleh, AM; Martinez, Mdel C; Meiss, RP | 1 |
| Carter, M; Dailey, HA; Dailey, TA; Lanzilotta, WN; Medlock, AE | 1 |
| Gerhard, GS; Zhang, S | 1 |
| Babushkin, T; Hait-Darshan, R; Malik, Z | 1 |
| Bolsen, K; Gardlo, K; Hanneken, S; Neumann, NJ; Siegesmund, M | 1 |
| Biswas, A; Chakravarti, R; Ghosh, A; Haque, MM; Panda, K; Stuehr, DJ; Waheed, SM | 1 |
| Couvé, E; Derré-Bobillot, A; Fernandez, A; Gaudu, P; Gruss, A; Lechardeur, D | 1 |
| Brugna, M; Hederstedt, L; Tasse, L | 1 |
| Abkowitz, JL; Doty, RT; Giraudi, P; Ostrow, JD; Philips, JD; Smith, A; Tiribelli, C; Yang, Z | 1 |
| Arnaud, O; Desuzinges-Mandon, E; Di Pietro, A; Falson, P; Huché, F; Martinez, L | 1 |
| Félix, V; Goodfellow, BJ; Macedo, AL; Micaelo, NM | 1 |
| Ha-Thi, MH; Poisson, L; Shafizadeh, N; Soep, B | 1 |
| Fukaya, H; Nakamura, T; Saito, M; Shida, Y; Shimada, Y; Tokuji, Y | 1 |
| Anteneodo, C; Cuya Guizado, TR; Louro, SR | 1 |
| Kaplan, J; Khalimonchuk, O; Paw, BH; Phillips, J; Spangrude, GJ; Thomas, K; Troadec, MB; Wallace, J; Ward, DM; Warner, D | 1 |
| Mayer, JM; Warren, JJ | 1 |
| Fujita, H; Inoue, K; Inoue, M; Kobuchi, H; Munetomo, K; Ogino, T; Sasaki, J; Shuin, T; Utsumi, K; Utsumi, T; Yamamoto, M | 1 |
| Aoki, R; Fujita, Y; Goto, T | 1 |
| Grigg, JC; Mao, CX; Murphy, ME | 1 |
| Du, G; Fan, Y; Fukuda, Y; Lynch, J; Nachagari, D; Potter, PM; Rehg, JE; Schuetz, JD; Sun, D; Tsurkan, L; Ulrich, DL; Wang, Y | 1 |
| Bode, J; Gavish, M; Katz, Y; Veenman, L; Zaaroor, M; Zeno, S | 1 |
| Balzarini, J; Bharatam, PV; Chibale, K; Kaur, H; Little, S; Singh, K | 1 |
| Chavan, H; Krishnamurthy, P | 1 |
| Crowley, JR; Goldberg, DE; Henderson, JP; Hsieh, S; Sigala, PA | 1 |
| Alayash, AI; Karnaukhova, E; Krupnikova, SS; Rajabi, M | 1 |
| Bielecki, M; Olczak, M; Olczak, T; Smalley, JW; Wojaczyński, J; Wójtowicz, H | 1 |
| Augustyniak, K; Débarbouillé, M; Gilles, AM; Turlin, E; Wandersman, C | 1 |
| Cheng, J; Csanaky, IL; Gonzalez, FJ; Klaassen, CD; Li, F; Lu, J; Ma, X; Matsubara, T; Wang, L | 1 |
| Cai, H; Grunwald, EW; Lei, B; Park, SY; Richards, MP | 1 |
| Chen, X; Fu, C; Gao, C; Han, D; Ji, Z; Li, H; Li, X; Liu, H; Liu, Y; Liu, Z; Shi, H; Wang, C; Wang, L; Wu, J; Yang, G; Yin, F; Zhang, D; Zhao, S | 1 |
| Ando, H; Gupta, V; Handa, H; Ishii, R; Kaneko, Y; Liu, S; Nureki, O; Sakamoto, S; Tateno, S; Yamaguchi, Y; Yugami, M | 1 |
| Dreher, C; Schaetzel, C; Schneider, D; Tome, L | 1 |
| Akiyama, S; Arimura, H; Fukushige, T; Furukawa, T; Kanekura, T; Minami, K; Nakagawa, M; Nishizawa, Y; Tanimoto, A; Yamamoto, M | 1 |
| Chen, M; Loughlin, PC; Willows, RD | 1 |
| Bauer, DE; Cantor, AB; Chen, W; Cooney, JD; Dailey, HA; Dailey, TA; Dass, A; DiMauro, S; Garone, C; Gwynn, B; Hattangadi, SM; Hildick-Smith, GJ; Huang, H; Kaplan, J; Keenan, EM; Kingsley, PD; Koehler, CM; Li, L; Lodish, HF; Miyata, N; Mohler, K; Orkin, SH; Palis, J; Paw, BH; Peters, LL; Phillips, JD; Pierce, EL; Robledo, RF; Schlaeger, TM; Schultz, IJ; Shah, DI; Takahashi-Makise, N; Ward, DM; Yi, G; Yien, YY | 1 |
| Alves, LS; Bozza, MT; de Oliveira, RB; Dutra, FF; Fernandez, PL; Golenbock, DT; Rodrigues, D; Zamboni, DS | 1 |
| Bohle, DS; Dodd, EL | 1 |
| Bodmer, SI; Harms, FA; Mik, EG; Raat, NJ | 1 |
| Akhter, F; Eichenbaum, Z; Le Breton, Y; McIver, KS; Sachla, AJ | 1 |
| Busch, AW; Montgomery, BL | 1 |
| Fukuhara, H; Hagiya, Y; Hayashi, M; Inoue, K; Nakajima, M; Ogura, S; Shuin, T; Tanaka, T | 1 |
| Aoki, K; Hayashi, T; Igarashi, K; Itoh, K; Jang, KJ; Mano, H; Muto, A; Nambu, Y; Nutt, SL; Shimizu, A; Sugai, M; Takahashi, K; Taketani, S | 1 |
| Nakanishi, T; Ogawa, T; Tamai, I; Yanagihara, C | 1 |
| Crowley, JR; Goldberg, DE; Henderson, JP; Sigala, PA | 1 |
| Chen, B; Kraus, D; Palasuberniam, P; Yang, X | 1 |
| Cohen, R; Morohaku, K; Mukai, C; Pillai, VV; Selvaraj, V; Sirivelu, MP; Tu, LN; Zhao, AH | 1 |
| Bielawski, KP; Filipiak, M; Grinholc, M; Hewelt-Belka, W; Kossakowska-Zwierucho, M; Nakonieczna, J | 1 |
| Fujino, M; Ito, H; Li, XK; Nishio, Y; Tanaka, T | 1 |
| Chollet, S; De Maere, H; De Mey, E; Dewulf, L; Fraeye, I; Michiels, C; Paelinck, H | 1 |
| Albert, N; Ben Yaakov, D; Carmeli, S; Dietl, AM; Haas, H; Kontoyiannis, DP; Kovalerchick, D; Mircus, G; Osherov, N; Rivkin, A | 1 |
| An, W; Dai, J; Gu, B; He, Z; Kempher, ML; Qiu, D; Tian, C; Wei, H; Xie, M; Zhou, A; Zhou, J | 1 |
| Arbelo-Lopez, HD; Lopez-Garriga, J; Simakov, NA; Smith, JC; Wymore, T | 1 |
| Chen, B; Myers, KA; Palasuberniam, P; Wang, C; Yang, X | 1 |
| Chapman, MS; Davis, SC; de Souza, AL; Gunn, J; Hasan, T; Kanick, SC; Marra, K; Maytin, EV; Pogue, BW; Samkoe, KS | 1 |
| Dailey, HA; Hobbs, C; Shepherd, M | 1 |
| Hamdi, A; Kahawita, TM; Mason, AB; Ponka, P; Roshan, TM; Sheftel, AD | 1 |
| Diao, Y; He, Q; Huang, H; Liang, H; Nakajima, O; Peng, Y; Wang, W; Zhang, L; Zhou, L; Zou, J | 1 |
| Brings, L; Fan, T; Grimm, B; Hedtke, B; Hey, D; Ortega-Rodes, P; Schnurrer, F | 1 |
| Dailey, HA; Dailey, TA; Gerdes, S; Jahn, D; Jahn, M; O'Brian, MR; Warren, MJ | 1 |
| Anand, S; Brankov, N; Brash, DE; Hasan, T; Maytin, EV; Rollakanti, KR | 1 |
| Goldenberg, H; Moganty, RR; Muckenthaler, MU; Scheiber-Mojdehkar, B; Singh, HN; Steinkellner, H; Sturm, B | 1 |
| Arenas, FA; Cornejo, FA; Luraschi, R; Morales, EH; Mori, H; Muñoz-Villagrán, CM; Myers, CL; Nelson, J; Pinto, CA; Piotrowski, JS; Simpkins, SW; Vásquez, CC | 1 |
| Gao, Z; Li, H; Wu, J; Yang, Z; Zhao, J | 1 |
| Chollet, S; De Brabanter, J; De Maere, H; Fraeye, I; Michiels, C; Paelinck, H | 1 |
| Chidgey, JW; Dickman, MJ; Hunter, CN; Jackson, PJ | 1 |
| Barui, A; Chakraborty, B; Chatterjee, K; Chattopadhyay, D; Ojha, D; RoyChaudhuri, C; Sarkar, R; Sengupta, S | 1 |
| Anand, S; Davis, SC; Denisyuk, A; Hu, B; Ishak, R; Karpinski, L; Kyei, A; Lohser, S; Maytin, EV; Riha, M; Sot, J; Tellez, A; Vidimos, A | 1 |
| Allaf, B; Gil, S; Gouya, L; Lefebvre, T; Manceau, H; Muller, F; Peoc'h, K; Puy, H; Puy, V; Rosenblatt, J; Schmitt, CM | 1 |
| Chakrabarti, A; Das, D; Tarafdar, PK | 1 |
| Kadasala, NR; Lin, L; Maltais, TR; Morales-de-Echegaray, AV; Seleem, MN; Wei, A; Younis, W | 1 |
| Armas, AM; Balparda, M; Busi, MV; Gomez-Casati, DF; Pagani, MA; Terenzi, A | 1 |
| Brewer, CT; Chen, T; Edwards, A; Lee, RE; Low, J; Lu, Y; Wu, J; Yang, L | 1 |
| Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H | 1 |
| Dan, S; Ishii, T; Ishizuka, M; Kitajima, Y; Kohda, T; Nakajima, M; Nishimura, Y; Tanaka, T; Yamazaki, K | 1 |
| Bonkovsky, HL; Bragazzi Cunha, J; Elenbaas, JS; Maitra, D; Omary, MB; Shavit, JA | 1 |
| Dai, J; Gao, N; Li, S; Liu, S; Liu, Y; Qiu, D; Wang, J; Zhou, J | 1 |
| Gleadle, JM; MacGregor, MN; McNicholas, K | 1 |
| Chan, KM; Gleadle, J; MacGregor, M; Vasilev, K | 1 |
| Kornitzer, D; Roy, U | 1 |
| Čunderlíková, B; Jerigová, M; Kalafutová, A; Teplický, T | 1 |
| Abe, J; Fantel, AG; Ihara, R; Inawaka, K; Kawamura, S; Miyamoto, T; Otani, M | 1 |
| Al-Jaff, G; den Engelsen, D; Fern, GR; Ireland, TG; Silver, J; Wilson, MT | 1 |
| Harada, Y; Murayama, Y; Otsuji, E; Takamatsu, T; Tanaka, H | 1 |
| Chen, B; Howley, R; Mansi, M; Restrepo, J; Shinde, J | 1 |
| Kiening, M; Lange, N | 1 |
| Ma, X; Qi, Q; Xu, L; Zhu, J | 1 |
| Chan, ACK; Do, LTM; McGregor, AK; Murphy, MEP; Saini, G; Schroeder, MD; Wolthers, KR | 1 |
| Fukuda, Y; Grace, CR; Kavdia, K; Li, Y; Lynch, J; Peng, J; Ranjit, S; Robinson, CG; Schuetz, JD; Wang, Y; Xia, Y | 1 |
18 review(s) available for protoporphyrin ix and heme
| Article | Year |
|---|---|
Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Photochemotherapy; Prodrugs; Protoporphyrins | 1992 |
Control of heme catabolism by Sn-protoporphyrin.
Topics: Heme; Humans; Porphyrins; Protoporphyrins | 1989 |
Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept.
Topics: Animals; Cattle; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Metalloporphyrins; Mice; Models, Biological; Nitroso Compounds; Phenylhydrazines; Protein Conformation; Protoporphyrins; Rats | 1984 |
[Porphyrin biosynthetic pathway and its regulation].
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Erythrocytes; Heme; Liver; Porphyrins; Protoporphyrins | 1995 |
[Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria].
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Porphyrias; Porphyrins; Protoporphyrins | 1995 |
5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges.
Topics: Aminolevulinic Acid; Forecasting; Heme; Humans; Neoplasms; Photochemotherapy; Protoporphyrins; Research; Skin Diseases; Skin Neoplasms | 1997 |
On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation.
Topics: Aminolevulinic Acid; Animals; Hematoporphyrin Photoradiation; Heme; Humans; Molecular Structure; Neoplasms; Photosensitizing Agents; Protoporphyrins | 2004 |
Use of ALA and ALA derivatives for optimizing ALA-based photodynamic therapy: a review of our experience.
Topics: Aminolevulinic Acid; Animals; Esterases; Heme; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2006 |
Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response.
Topics: Catalase; Cyanobacteria; Heme; Iron; Light; Light Signal Transduction; Oxidation-Reduction; Oxidative Stress; Peroxidase; Photosynthesis; Phytochrome; Plants; Protoporphyrins; Reactive Oxygen Species; Superoxide Dismutase; Tetrapyrroles | 2015 |
Aminolevulinic Acid-Based Tumor Detection and Therapy: Molecular Mechanisms and Strategies for Enhancement.
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2015 |
5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction.
Topics: Aminolevulinic Acid; Heme; Heme Oxygenase-1; Histocompatibility; Humans; Immunity; Immunologic Factors; Inflammation; Macrophages; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction; Transplantation, Homologous | 2016 |
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.
Topics: Aminolevulinic Acid; Archaea; Bacteria; Coproporphyrinogen Oxidase; Coproporphyrins; Heme; Iron; Protoporphyrins; Tetrapyrroles; Uroporphyrinogen Decarboxylase | 2017 |
Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury.
Topics: Animals; Carcinoma, Hepatocellular; Dermatitis, Phototoxic; Heme; Humans; Liver; Liver Neoplasms; Mice; Oxidation-Reduction; Oxidative Stress; Photosensitivity Disorders; Porphyrias; Porphyrins; Protein Aggregates; Protoporphyrins; Uroporphyrins; Zebrafish | 2019 |
In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?
Topics: Amino Acid Transport Systems; Aminolevulinic Acid; Brain Neoplasms; Coproporphyrinogens; Ferrochelatase; Fluorescence; Glucose; Heme; Humans; Iron; MicroRNAs; Mitochondria; Mutation; NADP; Neoplasms; Oncogenes; Optical Imaging; Peptide Transporter 1; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Symporters; Tumor Hypoxia; Tumor Microenvironment; Urinary Bladder Neoplasms | 2019 |
Pathways of heme utilization in fungi.
Topics: Candida albicans; Cryptococcus neoformans; Endocytosis; Heme; Iron; Protoporphyrins; Schizosaccharomyces; Signal Transduction | 2020 |
5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Glioma; Heme; Humans; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiopharmaceuticals | 2022 |
A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells.
Topics: Aminolevulinic Acid; Animals; Heme; Iron; Mammals; Neoplasms; Porphyrins; Protoporphyrins | 2022 |
Topics: Animals; Ferrochelatase; Heme; Porphyrins; Protoporphyrins | 2022 |
2 trial(s) available for protoporphyrin ix and heme
| Article | Year |
|---|---|
The prognostic value of cord blood analysis in erythropoietic protoporphyria: the 'Duesseldorf Cord Blood Study'.
Topics: Erythrocytes; Female; Ferrochelatase; Fetal Blood; Follow-Up Studies; Germany; Heme; Humans; Infant, Newborn; Male; Predictive Value of Tests; Prognosis; Protoporphyria, Erythropoietic; Protoporphyrins | 2010 |
5-Fluorouracil Enhances Protoporphyrin IX Accumulation and Lesion Clearance during Photodynamic Therapy of Actinic Keratoses: A Mechanism-Based Clinical Trial.
Topics: Apoptosis; Biomarkers; Biopsy; Fluorouracil; Heme; Humans; Keratosis, Actinic; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2018 |
194 other study(ies) available for protoporphyrin ix and heme
| Article | Year |
|---|---|
The rotational diffusion of cytochrome b5 in lipid bilayer membranes. Influence of the lipid physical state.
Topics: Animals; Cattle; Cytochromes; Cytochromes b5; Diffusion; Heme; Intracellular Membranes; Kinetics; Lipid Bilayers; Microsomes, Liver; Protoporphyrins; Rhodium; Spectrophotometry | 1979 |
Spectroscopic identification of the haem axial ligands of haemoferritin and location of possible haem-binding sites in ferritin by molecular modelling.
Topics: Animals; Binding Sites; Circular Dichroism; Electron Spin Resonance Spectroscopy; Ferritins; Heme; Hemeproteins; Horses; Humans; Iron; Models, Molecular; Protein Structure, Secondary; Protoporphyrins; Spectrum Analysis | 1992 |
Metal-metal interaction inhibits the NADP(+)-specific isocitrate dehydrogenase activity in rat brain.
Topics: Animals; Brain; Female; Heme; Isocitrate Dehydrogenase; Metalloporphyrins; Metals; NADP; Protoporphyrins; Rats; Rats, Wistar | 1992 |
On the use of iron octa-alkylporphyrins as models for protoporphyrin IX-containing heme systems in studies employing magnetic circular dichroism spectroscopy.
Topics: Animals; Circular Dichroism; Heme; Horseradish Peroxidase; Horses; Magnetics; Mesoporphyrins; Myoglobin; Protoporphyrins; Whales | 1992 |
Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Blotting, Northern; Feedback; Hematologic Diseases; Heme; Humans; Kinetics; Protein Synthesis Inhibitors; Protoporphyrins; Reticulocytes; RNA, Messenger | 1991 |
P460 of hydroxylamine oxidoreductase of Nitrosomonas europaea: Soret resonance Raman evidence for a novel heme-like structure.
Topics: Binding Sites; Chlorophyll; Heme; Nitrosomonas; Oxidoreductases; Pigments, Biological; Porphyrins; Protein Conformation; Protoporphyrins; Spectrum Analysis, Raman | 1991 |
Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species.
Topics: Animals; Aorta; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Granulocytes; Heme; Hemin; Hemopexin; Hydrogen Peroxide; Neutrophils; Oxygen; Protoporphyrins; Swine; Xanthine Oxidase; Xanthines | 1991 |
Suicidal inactivation of cytochrome P-450 by halothane and carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Halothane; Heme; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Protoporphyrins; Rats; Rats, Inbred Strains | 1991 |
Voltammetric studies on the electrochemical behaviour of membrane-entrapped hemes.
Topics: Electrochemistry; Electron Transport; Heme; Iron; Membranes, Artificial; Protoporphyrins | 1990 |
Derepression of ferritin messenger RNA translation by hemin in vitro.
Topics: Binding Sites; Binding, Competitive; Electrophoresis, Polyacrylamide Gel; Ferritins; Free Radicals; Heme; Hemin; Iron Chelating Agents; Protein Biosynthesis; Protoporphyrins; Repressor Proteins; RNA, Messenger; Transcription Factors | 1990 |
Porphyrin ring source can alter the outer membrane protein profile of non-typable Haemophilus influenzae.
Topics: Bacterial Outer Membrane Proteins; Haemophilus influenzae; Heme; Hemin; Immunoblotting; Peptide Biosynthesis; Phenotype; Porphyrins; Protoporphyrins | 1990 |
Pharmacological activities of delta-aminolaevulinic acid, protoporphyrin IX and haemin in isolated preparations of rabbit gastric fundus and jejunum.
Topics: Aminolevulinic Acid; Animals; Female; Gastric Fundus; Heme; Hemin; In Vitro Techniques; Jejunum; Levulinic Acids; Male; Muscle Contraction; Muscle, Smooth; Porphyrins; Prazosin; Protoporphyrins; Rabbits | 1990 |
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine | 1987 |
Cytochrome P-450 inactivation by 3-alkylsydnones. Mechanistic implications of N-alkyl and N-alkenyl heme adduct formation.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; NADP; Oxadiazoles; Oxidation-Reduction; Protein Binding; Protoporphyrins; Rats; Rats, Inbred Strains; Sydnones | 1988 |
Regulation of intestinal mucosa guanylate cyclase by hemin, heme and protoporphyrin IX.
Topics: Animals; Bacterial Toxins; Dimethyl Sulfoxide; Dithiothreitol; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Heme; Hemin; Intestinal Mucosa; Manganese; Microvilli; Nitric Oxide; Polyethylene Glycols; Porphyrins; Protoporphyrins; Swine | 1987 |
Mechanism-based inactivation of horseradish peroxidase by sodium azide. Formation of meso-azidoprotoporphyrin IX.
Topics: Azides; Heme; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; Magnetic Resonance Spectroscopy; Peroxidases; Porphyrins; Protoporphyrins | 1988 |
Inhibition of ferrochelatase during differentiation of murine erythroleukaemia cells.
Topics: Animals; Cations, Divalent; Cell Differentiation; Dicarbethoxydihydrocollidine; Dimethyl Sulfoxide; Ferrochelatase; Heme; Leukemia, Erythroblastic, Acute; Lyases; Mice; Organometallic Compounds; Protoporphyrins | 1987 |
Pharmacological effects of haem biosynthetic intermediates in isolated intestinal preparations.
Topics: Aminolevulinic Acid; Animals; Colon; Coproporphyrins; Female; Glycine; Heme; Hemin; In Vitro Techniques; Intestinal Mucosa; Intestines; Jejunum; Male; Muscle Contraction; Porphobilinogen; Protoporphyrins; Rabbits; Succinates | 1987 |
Structural requirements for porphyrin inhibition of the hemin-controlled protein kinase and maintenance of protein synthesis in reticulocytes.
Topics: Animals; Cobalt; Coproporphyrins; Eukaryotic Initiation Factor-2; Heme; Hemin; Magnesium; Peptide Initiation Factors; Phosphorylation; Porphyrins; Protein Biosynthesis; Protein Kinase Inhibitors; Proteins; Protoporphyrins; Rabbits; Reticulocytes; Zinc | 1986 |
Fluctuation domains in myoglobin. Fluorescence quenching studies.
Topics: Heme; Myoglobin; Oxygen; Protoporphyrins; Spectrometry, Fluorescence | 1987 |
Regulation of transferrin receptors in human hematopoietic cell lines.
Topics: Antibodies, Monoclonal; Apoproteins; Cell Division; Cell Line; Heme; Humans; In Vitro Techniques; Iron; Leukemia; Picolinic Acids; Protoporphyrins; Receptors, Cell Surface; Receptors, Transferrin; Time Factors; Transferrin | 1984 |
Activation of purified soluble guanylate cyclase by protoporphyrin IX.
Topics: Animals; Cattle; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemin; Kinetics; Lung; Nitric Oxide; Porphyrins; Protoporphyrins | 1982 |
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme.
Topics: Animals; Cattle; Guanylate Cyclase; Heme; Kinetics; Lung; Magnesium; Porphyrins; Protoporphyrins | 1982 |
Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX.
Topics: Animals; Enzyme Activation; Guanylate Cyclase; Heme; Liver; Nitric Oxide; Nitroso Compounds; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Solubility | 1982 |
Regulation of rat hepatic delta-aminolevulinic acid synthetase and heme oxygenase activities: evidence for control by heme and against mediation by prosthetic iron.
Topics: 5-Aminolevulinate Synthetase; Animals; Bilirubin; Cobalt; Deferoxamine; Dextrans; Edetic Acid; Heme; Heme Oxygenase (Decyclizing); Iron-Dextran Complex; Kinetics; Liver; Male; Mixed Function Oxygenases; Protoporphyrins; Rats | 1983 |
[Modulation of the expression of transferrin receptors by iron, hemin and protoporphyrin IX].
Topics: Animals; Cell Line; Cells, Cultured; Heme; Hemin; Humans; Iron; Leukemia; Porphyrins; Protoporphyrins; Receptors, Cell Surface; Receptors, Transferrin | 1983 |
Protoporphyrinogen oxidase and ferrochelatase in porphyria variegata.
Topics: Adult; Ascorbic Acid; Chlorides; Female; Ferric Compounds; Ferrochelatase; Ferrous Compounds; Flavoproteins; Glutathione; Heme; Humans; Leukocytes; Lyases; Male; Middle Aged; Mitochondrial Proteins; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Porphyrias; Protoporphyrinogen Oxidase; Protoporphyrins | 1983 |
Prostaglandin H synthase. Stoichiometry of heme cofactor.
Topics: Animals; Apoenzymes; Binding Sites; Heme; Kinetics; Macromolecular Substances; Male; Molecular Weight; Prostaglandin-Endoperoxide Synthases; Protein Binding; Protoporphyrins; Seminal Vesicles; Sheep; Spectrophotometry | 1984 |
Diamagnetism of human apo-, oxy-, and (carbonmonoxy)hemoglobin.
Topics: Apoproteins; Carboxyhemoglobin; Heme; Hemoglobins; Humans; Ligands; Magnetics; Oxyhemoglobins; Protein Binding; Protoporphyrins | 1984 |
Growth cycle-dependent overproduction and accumulation of protoporphyrin IX in Tetrahymena: effect of heavy metals.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Cycle; Cobalt; Heme; Porphyrins; Protoporphyrins; Tetrahymena pyriformis; Tin | 1982 |
Mechanism of thiamine-induced respiratory deficiency in Saccharomyces carlsbergensis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrins; Cytochromes; Heme; Protoporphyrins; Pyridoxine; Saccharomyces; Thiamine | 1981 |
Ferritin iron as substrate for synthesis of protoheme in intact rat liver mitochondria.
Topics: Animals; Ferritins; Flavin Mononucleotide; Heme; Iron; Kinetics; Membrane Potentials; Mitochondria, Liver; Oxidative Phosphorylation; Phenanthrolines; Protoporphyrins; Rats | 1981 |
Mitogenic and co-mitogenic properties of hemin.
Topics: Adult; Aminolevulinic Acid; Animals; Biliverdine; Cattle; Concanavalin A; Heme; Hemin; Horses; Humans; Immunity, Cellular; Lymphocyte Activation; Middle Aged; Mitogens; Protoporphyrins; Thymidine | 1981 |
Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct.
Topics: Alkylation; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochromes; Cytochromes b5; Heme; In Vitro Techniques; Macromolecular Substances; Male; Microsomes, Liver; Protoporphyrins; Rats; Rats, Inbred Strains; Spectrophotometry; Triazoles | 1981 |
Phototaxis away from blue light by an Escherichia coli mutant accumulating protoporphyrin IX.
Topics: Anaerobiosis; Cell Movement; Chemotaxis; Escherichia coli; Ferrochelatase; Genes, Bacterial; Heme; Humans; Light; Mutation; Oxygen; Porphyria, Erythropoietic; Protoporphyrins | 1995 |
The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA).
Topics: Aminolevulinic Acid; Cells, Cultured; Heme; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Photochemotherapy; Protoporphyrins; Receptors, Transferrin; Reference Values; Sezary Syndrome; Skin Neoplasms | 1995 |
Thermal broadening of the Soret band in heme complexes and in heme-proteins: role of iron dynamics.
Topics: Animals; Carboxyhemoglobin; Cattle; Heme; Hemeproteins; Hemoglobins; Hot Temperature; Iron; Myoglobin; Protoporphyrins; Spectrophotometry; Thermodynamics | 1994 |
Structure of the green heme in myeloperoxidase.
Topics: Crystallography, X-Ray; Heme; Humans; Models, Molecular; Peroxidase; Protoporphyrins | 1995 |
Stark-effect experiments on photochemical holes in chromoproteins: protoporphyrin IX-substituted myoglobin.
Topics: Animals; Heme; Horses; Myoglobin; Photochemistry; Protein Binding; Protoporphyrins; Spectrophotometry | 1995 |
Photodynamic therapy using 5-aminolaevulinic acid for experimental pancreatic cancer--prolonged animal survival.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cricetinae; Disease Models, Animal; Female; Heme; Injections, Intravenous; Lasers; Mesocricetus; Microscopy, Fluorescence; Neoplasm Transplantation; Pancreatic Neoplasms; Photochemotherapy; Protoporphyrins; Sensitivity and Specificity; Time Factors | 1994 |
The influence of porphyrogenic drugs on the glyoxalase enzymes.
Topics: Allylisopropylacetamide; Barbiturates; Chloramphenicol; Diazepam; Erythrocytes; Heme; Hemoglobins; Humans; Kinetics; Lactoylglutathione Lyase; Oxytetracycline; Porphyrias; Protoporphyrins; Spectrophotometry, Ultraviolet; Sulfamethazine; Thiolester Hydrolases | 1993 |
Hydrodynamics of horseradish peroxidase revealed by global analysis of multiple fluorescence probes.
Topics: Binding Sites; Biophysical Phenomena; Biophysics; Fluorescence Polarization; Fluorescent Dyes; Heme; Horseradish Peroxidase; Models, Chemical; Protein Conformation; Protoporphyrins | 1994 |
Dynamics of protoporphyrin IX in the heme pocket of horseradish peroxidase.
Topics: Apoproteins; Fluorescence Polarization; Heme; Horseradish Peroxidase; Myoglobin; Protoporphyrins; Solutions; Temperature | 1993 |
Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus influenzae type b.
Topics: Aerobiosis; Antibodies, Monoclonal; Apoproteins; Bacterial Proteins; Haemophilus influenzae; Heme; Hemopexin; Iron; Molecular Weight; Protoporphyrins; Receptors, Peptide | 1994 |
Study of the coordination chemistry of prostaglandin G/H synthase by resonance Raman spectroscopy.
Topics: Animals; Carbon Monoxide; Circular Dichroism; Dithionite; Ferrous Compounds; Heme; Hydrogen Bonding; Male; Molecular Structure; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Protoporphyrins; Seminal Vesicles; Sheep; Spectrophotometry; Spectrum Analysis, Raman | 1996 |
A functional heme-binding site of soluble guanylyl cyclase requires intact N-termini of alpha 1 and beta 1 subunits.
Topics: Animals; Binding Sites; Cattle; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Guanylate Cyclase; Heme; Kinetics; Ligands; Lung; Nitric Oxide; Protein Binding; Protoporphyrins; Recombinant Proteins; Sequence Deletion; Solubility; Spectrophotometry | 1996 |
Gene regulation of HBP 23 by metalloporphyrins and protoporphyrin IX in liver and hepatocyte cultures.
Topics: Animals; Carrier Proteins; Cells, Cultured; Cycloheximide; Dactinomycin; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Heme-Binding Proteins; Hemeproteins; Liver; Male; Metalloporphyrins; Protein Synthesis Inhibitors; Protoporphyrins; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic | 1997 |
Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Heme; Hydrogen Peroxide; Indomethacin; Leukotrienes; Lipid Peroxides; Lipoxygenase Inhibitors; Male; Peroxidase; Photosensitizing Agents; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Prostaglandins H; Protoporphyrins; Sheep; Spectrophotometry, Atomic | 1997 |
Elemental iron does repress transferrin, haemopexin and haemoglobin receptor expression in Haemophilus influenzae.
Topics: Carrier Proteins; Chlorides; Culture Media; Down-Regulation; Ferric Compounds; Haemophilus influenzae; Heme; Hemoglobins; Hemopexin; Iron-Binding Proteins; Protoporphyrins; Receptors, Cell Surface; Receptors, Peptide; Receptors, Transferrin; Transferrin; Transferrin-Binding Proteins | 1997 |
Comparison of delta-aminolaevulinic acid and its methyl ester as an inducer of porphyrin synthesis in cultured cells.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Extracellular Space; Heme; Liver; Photosensitizing Agents; Protoporphyrins; Rats; Stimulation, Chemical | 1997 |
Evidence for a novel heme adduct generated by the in vitro reaction of 2,4,6-trinitrotoluene with human hemoglobin using electrospray ionization mass spectrometry.
Topics: Heme; Hemoglobins; Humans; Iron; Mass Spectrometry; NADPH-Ferrihemoprotein Reductase; Protoporphyrins; Trinitrotoluene | 1997 |
Mechanism of YC-1-induced activation of soluble guanylyl cyclase.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Nitrogen Oxides; Photosensitizing Agents; Platelet Aggregation Inhibitors; Protoporphyrins; Solubility | 1998 |
1H and 13C NMR studies of a truncated heme domain from Chlorella vulgaris nitrate reductase: signal assignment of the heme moiety.
Topics: Animals; Binding Sites; Carbon Isotopes; Cattle; Chlorella; Cytochromes b5; Heme; Hydrogen; Liver; Models, Molecular; Nitrate Reductase; Nitrate Reductases; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Protein Conformation; Protoporphyrins | 1998 |
A new method for predicting the alignment of flexible molecules and orienting them in a receptor cleft of known structure.
Topics: Binding Sites; Heme; Models, Molecular; Molecular Structure; Myoglobin; Propionates; Protoporphyrins; Receptors, Cell Surface; Software; Thermodynamics | 1998 |
Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes.
Topics: Aminolevulinic Acid; Animals; Calcium; Cell Differentiation; Heme; Keratinocytes; Mice; Photochemotherapy; Porphobilinogen Synthase; Protoporphyrins; Rats; RNA, Messenger | 1998 |
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity.
Topics: Animals; Cattle; Enzyme Activation; Enzyme Inhibitors; Guanosine Triphosphate; Guanylate Cyclase; Heme; Heme Oxygenase (Decyclizing); Metalloporphyrins; Protein Binding; Protoporphyrins; Substrate Specificity | 1998 |
Effect of modified hemes on the spectral properties and activity of manganese peroxidase.
Topics: Enzyme Activation; Escherichia coli; Ferric Compounds; Heme; Kinetics; Peroxidases; Phanerochaete; Protoporphyrins; Recombinant Proteins; Spectrophotometry, Ultraviolet | 1998 |
Glutathione-S-transferase activity in malarial parasites.
Topics: Animals; Antimalarials; Chloroquine; Cricetinae; Drug Resistance; Glutathione Transferase; Heme; Humans; Macaca mulatta; Mesocricetus; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium knowlesi; Plasmodium yoelii; Protoporphyrins | 1999 |
A novel endogenous antimalarial: Fe(II)-protoporphyrin IX alpha (heme) inhibits hematin polymerization to beta-hematin (malaria pigment) and kills malaria parasites.
Topics: Animals; Antimalarials; Electrochemistry; Erythrocytes; Ferrous Compounds; Heme; Hemin; Humans; Oxidation-Reduction; Pigments, Biological; Plasmodium falciparum; Polymers; Protoporphyrins; Sulfhydryl Compounds | 1999 |
Protoporphyrin IX and oxidative stress.
Topics: 5-Aminolevulinate Synthetase; Animals; Antioxidants; Catalase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Heme; Liver; Male; Mice; Mice, Inbred Strains; Oxidants; Oxidative Stress; Porphobilinogen Synthase; Porphyrins; Protoporphyrins; Superoxide Dismutase | 1999 |
Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.
Topics: Animals; Bilirubin; Cell Division; Colon; Colonic Neoplasms; Feces; Ferric Compounds; Heme; Hemin; Intestinal Absorption; Intestinal Mucosa; Iron; Male; Protoporphyrins; Rats; Rats, Wistar; Specific Pathogen-Free Organisms | 1999 |
The periodontal pathogen Porphyromonas gingivalis harnesses the chemistry of the mu-oxo bishaem of iron protoporphyrin IX to protect against hydrogen peroxide.
Topics: Bacteroidaceae Infections; Colony Count, Microbial; Heme; Humans; Hydrogen Peroxide; Iron; Peroxidase; Porphyromonas gingivalis; Protoporphyrins; Virulence | 2000 |
A study of aminolevulinic acid-induced protoporphyrin IX fluorescence kinetics in the canine oral cavity.
Topics: Aminolevulinic Acid; Animals; Dogs; Dose-Response Relationship, Drug; Face; Female; Fiber Optic Technology; Fluorescence; Gingiva; Heme; Image Processing, Computer-Assisted; Mouth; Mouth Mucosa; Photosensitizing Agents; Protoporphyrins; Random Allocation; Skin; Spectrometry, Fluorescence; Time Factors; Tongue | 2000 |
Porphyrin biosynthesis in human Barrett's oesophagus and adenocarcinoma after ingestion of 5-aminolaevulinic acid.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Female; Ferrochelatase; Heme; Humans; Hydroxymethylbilane Synthase; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Porphobilinogen; Porphyrins; Protoporphyrins | 2000 |
A key role for the mitochondrial benzodiazepine receptor in cellular photosensitisation with delta-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fluorescence; Heme; Humans; Mitochondria; Photosensitizing Agents; Protoporphyrins; Rats; Receptors, GABA-A; Tumor Cells, Cultured | 2000 |
Growth stimulation of Porphyromonas endodontalis by hemoglobin and protoporphyrin IX.
Topics: Biological Transport, Active; Chlorides; Culture Media; Dental Pulp Cavity; Ferric Compounds; Heme; Hemoglobins; Iron; Porphyromonas; Protoporphyrins; Siderophores | 2000 |
Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-gamma-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamate.
Topics: Antioxidants; Cells, Cultured; Enzyme Activation; Enzyme Induction; Heme; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Macrophage Activation; Macrophages; Protein Processing, Post-Translational; Protoporphyrins; Pyrrolidines; Thiocarbamates; Tryptophan Oxygenase | 2001 |
Relaxometric characterization of human hemalbumin.
Topics: Binding Sites; Heme; Humans; Iron; Ligands; Magnetic Resonance Spectroscopy; Manganese; Protein Conformation; Protoporphyrins; Serum Albumin | 2001 |
Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifs.
Topics: Amino Acid Motifs; Amino Acid Substitution; Catalytic Domain; Circular Dichroism; Cysteine; Heme; Heme Oxygenase (Decyclizing); Humans; Hydrogen-Ion Concentration; Metalloporphyrins; Peptide Fragments; Proline; Protein Binding; Protoporphyrins; Spectrophotometry; Spectrophotometry, Ultraviolet; Sulfhydryl Reagents | 2001 |
Impaired expression of the plastidic ferrochelatase by antisense RNA synthesis leads to a necrotic phenotype of transformed tobacco plants.
Topics: Cloning, Molecular; Ferrochelatase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Heme; Isoenzymes; Light; Mitochondria; Necrosis; Nicotiana; Phenotype; Phylogeny; Plants, Genetically Modified; Plastids; Protoporphyrins; RNA, Antisense; RNA, Messenger; RNA, Plant | 2001 |
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.
Topics: Animals; Apoptosis; Blotting, Northern; Blotting, Western; Cell Lineage; Cell Separation; Cell Survival; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; eIF-2 Kinase; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Eukaryotic Initiation Factor-2; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Library; Genotype; Heme; Iron; Iron Deficiencies; Mice; Microscopy, Electron; Models, Biological; Phosphorylation; Polyribosomes; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Protoporphyrins; Reticulocytes; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological; Time Factors | 2001 |
Asp-225 and glu-375 in autocatalytic attachment of the prosthetic heme group of lactoperoxidase.
Topics: Animals; Aspartic Acid; Binding Sites; Catalysis; Cattle; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; Insecta; Iron; Lactoperoxidase; Models, Chemical; Models, Molecular; Mutation; Porphyrins; Protein Conformation; Protoporphyrins; Recombinant Proteins; Spectrophotometry | 2002 |
Isolation and characterization of a cDNA from soybean and its homolog from Escherichia coli, which both complement the light sensitivity of Escherichia coli hemH mutant strain VS101.
Topics: Aminolevulinic Acid; Bacteriophages; DNA, Bacterial; DNA, Complementary; Escherichia coli; Ferrochelatase; Gene Deletion; Genetic Complementation Test; Glycine max; Heme; Light; Lysogeny; Mutation; Open Reading Frames; Protoporphyrins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transformation, Genetic | 2001 |
Measurement of ferrochelatase activity using a novel assay suggests that plastids are the major site of haem biosynthesis in both photosynthetic and non-photosynthetic cells of pea (Pisum sativum L.).
Topics: Chloroplasts; Copper Sulfate; Ferrochelatase; Heme; Hydrogen-Ion Concentration; Kinetics; Mitochondria; Photosynthesis; Pisum sativum; Plants; Plastids; Porphyrins; Protoporphyrins | 2002 |
Histidine pK(a) shifts and changes of tautomeric states induced by the binding of gallium-protoporphyrin IX in the hemophore HasA(SM).
Topics: Bacterial Proteins; Binding Sites; Carrier Proteins; Crystallography, X-Ray; Escherichia coli; Gallium; Heme; Histidine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Membrane Proteins; Models, Molecular; Protein Binding; Protein Conformation; Protoporphyrins | 2002 |
Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization.
Topics: Animals; Cation Transport Proteins; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Down-Regulation; Erythrocytes; Frataxin; Friedreich Ataxia; Gene Expression Regulation; Globins; Heme; Humans; Iron; Iron-Binding Proteins; Kinetics; Mice; Phosphotransferases (Alcohol Group Acceptor); Protoporphyrins; Receptors, Transferrin; RNA, Messenger; Tumor Cells, Cultured | 2002 |
High-resolution structure and biochemical properties of a recombinant Proteus mirabilis catalase depleted in iron.
Topics: Acetates; Anions; Arginine; Binding Sites; Catalase; Catalysis; Crystallography, X-Ray; Heme; Hydrogen Bonding; Iron; Models, Molecular; NADP; Protein Conformation; Proteus mirabilis; Protoporphyrins; Recombinant Proteins; Spectrum Analysis; Sulfates | 2003 |
Heme-scavenging role of alpha1-microglobulin in chronic ulcers.
Topics: Alpha-Globulins; Body Fluids; Carbon Radioisotopes; Carcinoma, Hepatocellular; Chronic Disease; Dermatitis; Heme; Humans; Iron; Liver Neoplasms; Oxidative Stress; Protein Binding; Protoporphyrins; Tumor Cells, Cultured; Varicose Ulcer; Wound Healing | 2003 |
Preparation of heme-free soluble guanylate cyclase.
Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc | 2003 |
Hematin--requiring plasmodial myxomycete.
Topics: Animals; Chick Embryo; Culture Media; Heme; Hemeproteins; Hemin; Myxomycetes; Porphyrins; Protoporphyrins | 1962 |
Heme-iron increases levels of AP65-mediated adherence by Trichomonas vaginalis.
Topics: 2,2'-Dipyridyl; Animals; Antibodies, Protozoan; Cell Adhesion; Cell Adhesion Molecules; Chelating Agents; Epithelial Cells; Gene Expression; Growth Inhibitors; Heme; Hemin; Hemoglobins; Humans; Iron; Membrane Proteins; Protoporphyrins; Protozoan Proteins; RNA, Messenger; RNA, Protozoan; Trichomonas vaginalis | 2004 |
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blotting, Western; Bone Marrow Cells; Cell Survival; Coloring Agents; Estrone; Heme; Hemin; Humans; Hypoxia; Mice; Mice, Transgenic; Models, Biological; Mutation; Neoplasm Proteins; NIH 3T3 Cells; Oxygen; Porphyrins; Promoter Regions, Genetic; Protein Binding; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; Sepharose; Signal Transduction; Stem Cells; Transcriptional Activation; Transgenes; Up-Regulation | 2004 |
Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis.
Topics: Binding Sites; Calorimetry; Crystallography, X-Ray; Dimerization; Down-Regulation; Ferrochelatase; Frataxin; Heme; Humans; Iron; Iron-Binding Proteins; Iron-Sulfur Proteins; Kinetics; Models, Biological; Protein Binding; Protoporphyrins; Spectrometry, Fluorescence; Surface Plasmon Resonance; Time Factors | 2004 |
Proximal and distal influences on ligand binding kinetics in microperoxidase and heme model compounds.
Topics: Animals; Carbon Monoxide; Heart; Heme; Histidine; Horses; Imidazoles; Kinetics; Ligands; Models, Molecular; Myoglobin; Peroxidases; Photolysis; Protein Binding; Protein Conformation; Protoporphyrins; Spectrum Analysis, Raman; Time Factors | 2004 |
A novel Arabidopsis thaliana protein is a functional peripheral-type benzodiazepine receptor.
Topics: Arabidopsis; Arabidopsis Proteins; Benzodiazepines; Binding, Competitive; Carrier Proteins; Cholesterol; DNA, Complementary; Escherichia coli; Evolution, Molecular; Heme; Ligands; Microscopy, Electron; Mitochondria; Molecular Sequence Data; Phylogeny; Protoporphyrins; Radioligand Assay; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Steroids | 2004 |
Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex.
Topics: Arginine; Ascorbate Peroxidases; Binding Sites; Crystallography, X-Ray; Glycine max; Heme; Iron; Models, Molecular; Molecular Structure; Peroxidases; Protein Structure, Tertiary; Protons; Protoporphyrins; Salicylamides; Spectrophotometry | 2004 |
Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase.
Topics: Aminolevulinic Acid; Biochemistry; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Histidine; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Iron; Isopropyl Thiogalactoside; Kynurenine; Plasmids; Protoporphyrins; Recombinant Proteins; Temperature; Time Factors; Tryptophan; Tryptophan Oxygenase | 2004 |
Mechanism of in vitro heme-induced LDL oxidation: effects of antioxidants.
Topics: Antioxidants; Deferoxamine; Dose-Response Relationship, Drug; Heme; Humans; Hydrogen Peroxide; Iron Chelating Agents; Lipid Peroxidation; Lipoproteins, LDL; Oxidation-Reduction; Protoporphyrins; Vitamins | 2004 |
Protoporphyrin IX-induced structural and functional changes in human red blood cells, haemoglobin and myoglobin.
Topics: Adult; Binding Sites; Chromatography, Gel; Circular Dichroism; Erythrocytes; Heme; Hemoglobins; Humans; Myoglobin; Oxygen; Peroxidases; Photosensitizing Agents; Porphyrins; Protein Binding; Protein Conformation; Protoporphyrins; Spectrophotometry; Time Factors | 2004 |
Formation of a misfolded conformation during refolding of HRPA1 in the presence of calcium.
Topics: Calcium; Circular Dichroism; Heme; Horseradish Peroxidase; Protein Conformation; Protein Folding; Protoporphyrins; Temperature | 2005 |
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection | 2005 |
Functional characterization of the C-terminal domain of the cytochrome c maturation protein CcmE.
Topics: Anilino Naphthalenesulfonates; Bacterial Outer Membrane Proteins; Binding Sites; Cytochromes c; Escherichia coli; Escherichia coli Proteins; Heme; Hemeproteins; Mutagenesis, Site-Directed; Periplasm; Protein Binding; Protein Structure, Tertiary; Protoporphyrins | 2005 |
Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Coproporphyrinogen Oxidase; Cytochromes c; Ferrochelatase; Frataxin; Heart; Heme; Humans; Iron-Binding Proteins; Mammals; Mice; Mice, Knockout; Mitochondria; Molecular Sequence Data; Mutation; Myocardium; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins; Protoporphyrins; Sequence Homology, Amino Acid; Transcription, Genetic; Zinc | 2005 |
Non-covalent modification of the heme-pocket of apomyoglobin by a 1,10-phenanthroline derivative.
Topics: Animals; Apoproteins; Binding Sites; Heme; Ligands; Models, Molecular; Molecular Structure; Myoglobin; Phenanthrolines; Protoporphyrins; Species Specificity; Sperm Whale; Structure-Activity Relationship | 2006 |
Three-dimensional model of the human aromatase enzyme and density functional parameterization of the iron-containing protoporphyrin IX for a molecular dynamics study of heme-cysteinato cytochromes.
Topics: Animals; Aromatase; Calorimetry; Cysteine; Cytochrome P-450 Enzyme System; Cytochromes; Heme; Humans; Iron; Mammals; Models, Molecular; Protein Structure, Secondary; Protoporphyrins | 2006 |
A direct and simultaneous detection of zinc protoporphyrin IX, free protoporphyrin IX, and fluorescent heme degradation product in red blood cell hemolysates.
Topics: Animals; Erythrocytes; Fluorescence; Heme; Hemoglobin E; Hydrogen Peroxide; Mice; Mice, Transgenic; Oxidants; Protoporphyrins | 2006 |
The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX.
Topics: Adhesins, Bacterial; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Hemagglutinins; Heme; Humans; Porphyromonas gingivalis; Protoporphyrins | 2006 |
Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation.
Topics: Aminolevulinic Acid; Animals; Cattle; Deferoxamine; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heme; Iron; Models, Biological; Organ Culture Techniques; Oxidation-Reduction; Photosensitizing Agents; Protoporphyrins; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Serotonin; Soluble Guanylyl Cyclase; Vasodilation | 2006 |
The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Heme; Heme-Binding Proteins; Hemeproteins; Hemin; Humans; Mice; Molecular Sequence Data; Protein Structure, Secondary; Protoporphyrins; Sequence Homology, Amino Acid; Tetrapyrroles | 2006 |
Cloning and characterization of a novel periplasmic heme-transport protein from the human pathogen Pseudomonas aeruginosa.
Topics: Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Heme; Humans; Periplasmic Proteins; Protoporphyrins; Pseudomonas aeruginosa; Sequence Alignment; Spectrum Analysis | 2007 |
DNA-directed immobilization of horseradish peroxidase-DNA conjugates on microelectrode arrays: towards electrochemical screening of enzyme libraries.
Topics: Biosensing Techniques; Chromatography, Liquid; Clinical Enzyme Tests; DNA; DNA Probes; Electrochemistry; Enzymes, Immobilized; Gold; Heme; Horseradish Peroxidase; Kinetics; Microelectrodes; Oxidation-Reduction; Phenols; Phenylenediamines; Protoporphyrins; Spectrophotometry, Ultraviolet | 2007 |
Characterization of heme as activator of Toll-like receptor 4.
Topics: Animals; Cells, Cultured; Cytokines; Drug Antagonism; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase-1; Hemolysis; Immunity, Innate; Inflammation; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; Neutrophils; Photosensitizing Agents; Protoporphyrins; Respiratory Burst; Signal Transduction; Toll-Like Receptor 4 | 2007 |
A new dinuclear heme-copper complex derived from functionalized protoporphyrin IX.
Topics: Biomimetics; Copper; Heme; Hydrogen Peroxide; Iron; Magnetic Resonance Spectroscopy; Models, Biological; Molecular Structure; Organometallic Compounds; Photosensitizing Agents; Protoporphyrins | 2007 |
Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.
Topics: Aspergillus nidulans; Bacterial Proteins; CCAAT-Binding Factor; DNA, Fungal; Fungal Proteins; GATA Transcription Factors; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Lethal; Heme; Iron; Molecular Structure; Protein Binding; Protein Subunits; Protoporphyrins; Regulon; Repressor Proteins; Siderophores; Signal Transduction; Surface Plasmon Resonance | 2007 |
Detection of heme oxygenase activity in a library of four-helix bundle proteins: towards the de novo synthesis of functional heme proteins.
Topics: Amino Acid Sequence; Catalysis; Cellulose; Centrifugation; Electrochemistry; Electron Spin Resonance Spectroscopy; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Peptide Library; Peptides; Protein Structure, Quaternary; Protein Structure, Secondary; Protoporphyrins; Solutions; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Time Factors; Titrimetry | 2007 |
Interaction of heme and heme-hemopexin with an extracellular oxidant system used to measure cell growth-associated plasma membrane electron transport.
Topics: Biological Transport; Cell Membrane; Cell Proliferation; Dose-Response Relationship, Drug; Electrons; Heme; Hemopexin; HL-60 Cells; Humans; Kinetics; Models, Biological; Models, Chemical; Oxidants; Oxidoreductases; Protoporphyrins | 2007 |
Expression of genes involved in heme biosynthesis in the human retinoblastoma cell lines WERI-Rb-1 and Y79: implications for photodynamic therapy.
Topics: 5-Aminolevulinate Synthetase; Cell Line, Tumor; Ferrochelatase; Gene Expression; Gene Expression Profiling; Genes, Neoplasm; Heme; Humans; Hydroxymethylbilane Synthase; Photochemotherapy; Photosensitizing Agents; Protoporphyrinogen Oxidase; Protoporphyrins; Retinal Neoplasms; Retinoblastoma | 2007 |
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Humans; Protoporphyrins; RNA, Messenger; RNA, Small Interfering; Stomach Neoplasms | 2008 |
A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase.
Topics: Binding Sites; Catalysis; Crystallography, X-Ray; Ferrochelatase; Heme; Humans; Models, Biological; Models, Molecular; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Protoporphyrins | 2007 |
Characterization of temperature-dependent iron-imidazole vibrational modes in far infrared.
Topics: Biomimetic Materials; Heme; Hydrogen Bonding; Imidazoles; Iron; Isotope Labeling; Ligands; Metalloproteins; Micelles; Protoporphyrins; Sodium Dodecyl Sulfate; Spectrophotometry, Infrared; Surface-Active Agents; Temperature | 2007 |
Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae.
Topics: Biological Transport; Cell Membrane; Heme; Membrane Transport Proteins; Oligonucleotide Array Sequence Analysis; Porphyrins; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2008 |
Heme, a plastid-derived regulator of nuclear gene expression in Chlamydomonas.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Nucleus; Chlamydomonas; Gene Expression Regulation; Heme; Lyases; Models, Biological; Molecular Sequence Data; Plastids; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Metal ion substrate inhibition of ferrochelatase.
Topics: Animals; Catalysis; Cations, Divalent; Ferrochelatase; Heme; Humans; Hydrogen-Ion Concentration; Imidazoles; Mercaptoethanol; Metals, Heavy; Mice; Oxidation-Reduction; Protoporphyrins; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity | 2008 |
The IsdC protein from Staphylococcus aureus uses a flexible binding pocket to capture heme.
Topics: Apoproteins; Binding Sites; Carrier Proteins; Crystallography, X-Ray; Heme; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protoporphyrins; Staphylococcus aureus; Zinc | 2008 |
Adenine nucleotide translocator transports haem precursors into mitochondria.
Topics: Animals; Heme; Hemeproteins; Kinetics; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Models, Molecular; Molecular Weight; Protein Conformation; Protoporphyrins; Rats | 2008 |
Ligand binding to the Fe(III)-protoporphyrin IX complex of phosphodiesterase from Escherichia coli (Ec DOS) markedly enhances catalysis of cyclic di-GMP: roles of Met95, Arg97, and Phe113 of the putative heme distal side in catalytic regulation and ligand
Topics: Animals; Arginine; Catalysis; Cattle; Cyclic GMP; Escherichia coli Proteins; Ferric Compounds; Heme; Ligands; Methionine; Mutagenesis, Site-Directed; Phenylalanine; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Tertiary; Protoporphyrins | 2008 |
The interplay between iron and zinc metabolism in Aspergillus fumigatus.
Topics: Aspergillus fumigatus; Carrier Proteins; Ferric Compounds; Ferrichrome; Fungal Proteins; Gene Expression Regulation, Fungal; Heme; Homeostasis; Hydroxamic Acids; Iron; Mycelium; Protoporphyrins; RNA, Fungal; Zinc | 2009 |
Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact.
Topics: Cation Transport Proteins; Chromatography, High Pressure Liquid; Escherichia coli; Escherichia coli Proteins; Heme; Iron; Iron-Binding Proteins; Mass Spectrometry; Protein Binding; Protoporphyrins; Tetrapyrroles | 2009 |
Hepatic damage and oxidative stress induced by Griseofulvin in mice.
Topics: Animals; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP3A; Disease Models, Animal; Griseofulvin; Heme; Heme Oxygenase (Decyclizing); Immunohistochemistry; Liver; Male; Mice; Oxidative Stress; Protoporphyria, Erythropoietic; Protoporphyrins; Tryptophan Oxygenase | 2009 |
Product release rather than chelation determines metal specificity for ferrochelatase.
Topics: Cadmium; Cobalt; Crystallography, X-Ray; Ferrochelatase; Heme; Humans; Iron; Lead; Mercury; Metals; Nickel; Protein Structure, Secondary; Protoporphyrins; Substrate Specificity; Zinc | 2009 |
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target.
Topics: Aminolevulinic Acid; Anti-Infective Agents; Antineoplastic Agents; Artemisinins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Heme; Humans; Iron; Models, Chemical; Protoporphyrins; Spectrophotometry; Transferrin | 2009 |
Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease.
Topics: Adenosine Triphosphatases; Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Line, Tumor; Cell Survival; Copper; Copper-Transporting ATPases; Disulfiram; Down-Regulation; Enzyme Inhibitors; Heme; Hepatocytes; Hepatolenticular Degeneration; Humans; Hydroxymethylbilane Synthase; Liver Neoplasms; Porphobilinogen Synthase; Proteasome Endopeptidase Complex; Protoporphyrins; Reactive Oxygen Species; Ubiquitin | 2009 |
Nitric oxide blocks cellular heme insertion into a broad range of heme proteins.
Topics: Animals; Catalase; Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Heme; Hemeproteins; Humans; K562 Cells; Mice; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroso Compounds; Protoporphyrins | 2010 |
Two coregulated efflux transporters modulate intracellular heme and protoporphyrin IX availability in Streptococcus agalactiae.
Topics: Animals; Bacterial Proteins; Blotting, Northern; Blotting, Western; Electrophoretic Mobility Shift Assay; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Heme; Membrane Transport Proteins; Mice; Operon; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; Streptococcus agalactiae | 2010 |
In vivo production of catalase containing haem analogues.
Topics: Catalase; Cobalt; Enterococcus faecalis; Gallium; Heme; Hemeproteins; Metalloporphyrins; Protoporphyrins | 2010 |
Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.
Topics: Animals; Biological Transport; Cell Line; Coproporphyrins; Heme; Hemolysis; Hemopexin; Hemorrhage; Homeostasis; Humans; Iron; Liver; Macrophages; Membrane Transport Proteins; Protoporphyrins; Rabbits; Rats; Receptors, Virus; Transferrin | 2010 |
ABCG2 transports and transfers heme to albumin through its large extracellular loop.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Hypoxia; Chlorophyll; Hematopoietic Stem Cells; Heme; Humans; K562 Cells; Mesoporphyrins; Neoplasm Proteins; Photosensitizing Agents; Point Mutation; Protein Structure, Secondary; Protoporphyrins; Serum Albumin; Vitamin B 12; Vitamin B Complex | 2010 |
Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Coproporphyrins; Heme; Heme-Binding Proteins; Hemeproteins; Hemin; Humans; Mice; Molecular Dynamics Simulation; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Protoporphyrins; Tetrapyrroles | 2010 |
First observation in the gas phase of the ultrafast electronic relaxation pathways of the S(2) states of heme and hemin.
Topics: Electrons; Gases; Heme; Hemin; Iron; Protoporphyrins; Zinc | 2010 |
Induction of aminolevulinic acid synthase gene expression and enhancement of metabolite, protoporphyrin IX, excretion by organic germanium.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Feces; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Germanium; Heme; Male; Mass Spectrometry; Organometallic Compounds; Propionates; Protoporphyrins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Hydration of hydrophobic biological porphyrins.
Topics: Heme; Molecular Dynamics Simulation; Protoporphyrins; Solvents; Water | 2011 |
Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria.
Topics: Anemia; Animals; Base Sequence; DNA Primers; Embryo Loss; Female; Gene Targeting; Heme; Hepatocytes; Iron; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Pregnancy; Protoporphyria, Erythropoietic; Protoporphyrins | 2011 |
Proton-coupled electron transfer reactions at a heme-propionate in an iron-protoporphyrin-IX model compound.
Topics: Crystallography, X-Ray; Electron Transport; Heme; Hydrogen Bonding; Models, Biological; Molecular Structure; Organometallic Compounds; Propionates; Protons; Protoporphyrins; Thermodynamics | 2011 |
Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cattle; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Space; Ferrochelatase; Gene Expression Regulation; Gene Knockdown Techniques; Heme; Humans; Indoles; Neoplasm Proteins; Nitroso Compounds; Protoporphyrins; Serum; Serum Albumin, Bovine | 2011 |
A heme oxygenase isoform is essential for aerobic growth in the cyanobacterium Synechocystis sp. PCC 6803: modes of differential operation of two isoforms/enzymes to adapt to low oxygen environments in cyanobacteria.
Topics: Adaptation, Physiological; Aerobiosis; Autotrophic Processes; Biosynthetic Pathways; Chlorophyll; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Gene Order; Genes, Bacterial; Genetic Complementation Test; Heme; Heme Oxygenase (Decyclizing); Light; Mutation; Oxygen; Phycocyanin; Protein Isoforms; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synechocystis; Tetrapyrroles | 2011 |
Iron-coordinating tyrosine is a key determinant of NEAT domain heme transfer.
Topics: Antigens, Bacterial; Binding Sites; Carrier Proteins; Cation Transport Proteins; Crystallography, X-Ray; Heme; Iron; Kinetics; Models, Chemical; Models, Molecular; Mutation; Myoglobin; Protein Binding; Protoporphyrins; Staphylococcus aureus; Tyrosine | 2011 |
ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Coproporphyrins; Erythropoiesis; Female; Gene Expression; Heme; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Mitochondria; Oxidants; Oxidative Stress; Phenylhydrazines; Porphyrins; Protoporphyrins | 2012 |
The 18 kDa mitochondrial translocator protein (TSPO) prevents accumulation of protoporphyrin IX. Involvement of reactive oxygen species (ROS).
Topics: Cell Death; Cell Line, Tumor; Free Radical Scavengers; Gene Knockdown Techniques; Glutathione; Heme; Humans; Mitochondria; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Receptors, GABA; RNA Interference | 2012 |
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; DNA; Dogs; Heme; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Plasmodium falciparum; Protoporphyrins; Pyrimidines; Structure-Activity Relationship; Viruses | 2012 |
Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR).
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Cell Line; Cell Survival; Cells, Cultured; Gene Expression Regulation; Heme; Hepatocytes; Humans; Hydrocarbons; Mice; Mice, Transgenic; Mitochondria; Models, Biological; Polycyclic Aromatic Hydrocarbons; Porphyrias; Promoter Regions, Genetic; Protein Binding; Protoporphyrins; Receptors, Aryl Hydrocarbon; Transcriptional Activation; Xenobiotics | 2012 |
Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum.
Topics: Amino Acid Sequence; Bilirubin; Biliverdine; Chromatography, High Pressure Liquid; Erythrocytes; Heme; Heme Oxygenase (Decyclizing); Humans; Malaria, Falciparum; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmodium falciparum; Protein Binding; Proteolysis; Protoporphyrins; Protozoan Proteins; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Tandem Mass Spectrometry | 2012 |
Heme binding to human alpha-1 proteinase inhibitor.
Topics: alpha 1-Antitrypsin; Bilirubin; Carrier Proteins; Circular Dichroism; Haptoglobins; Heme; Heme-Binding Proteins; Hemeproteins; Humans; Protein Conformation; Protoporphyrins; Spectrophotometry, Ultraviolet; Surface Plasmon Resonance; Trypsin Inhibitors | 2012 |
The Porphyromonas gingivalis HmuY haemophore binds gallium(iii), zinc(ii), cobalt(iii), manganese(iii), nickel(ii), and copper(ii) protoporphyrin IX but in a manner different to iron(iii) protoporphyrin IX.
Topics: Absorption; Bacterial Proteins; Circular Dichroism; Cobalt; Copper; Gallium; Heme; Hemeproteins; Histidine; Ligands; Magnetic Resonance Spectroscopy; Manganese; Metals; Mutant Proteins; Nickel; Porphyromonas gingivalis; Protein Binding; Protoporphyrins; Spectrophotometry, Ultraviolet; Zinc | 2013 |
Staphylococcus aureus FepA and FepB proteins drive heme iron utilization in Escherichia coli.
Topics: Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Escherichia coli; Escherichia coli Proteins; Heme; Hemeproteins; Iron; Membrane Transport Proteins; Operon; Periplasmic Proteins; Protein Binding; Protoporphyrins; Receptors, Cell Surface; Staphylococcus aureus | 2013 |
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Heme; Humans; Isoniazid; Liver; Male; Mice; Mice, Transgenic; Pregnane X Receptor; Protoporphyrins; Receptors, Steroid; Rifampin | 2013 |
Lipid oxidation in trout muscle is strongly inhibited by a protein that specifically binds hemin released from hemoglobin.
Topics: Aldehydes; Animals; Heme; Hemin; Hemoglobins; Hydrogen-Ion Concentration; Lipid Metabolism; Lipid Peroxides; Muscle, Skeletal; Myoglobin; Oncorhynchus mykiss; Oxidation-Reduction; Protoporphyrins; Recombinant Proteins; Thiobarbituric Acid Reactive Substances | 2013 |
Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Glioma; Heme; Humans; Intracellular Space; Oxides; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar | 2013 |
Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Crystallography, X-Ray; Embryo, Nonmammalian; Escherichia coli Proteins; Ferrochelatase; Heme; Humans; Mitochondria; Models, Molecular; Protein Binding; Protein Conformation; Protein Multimerization; Protoporphyrins; Salicylic Acid; Zebrafish | 2013 |
Fe- but not Mg-protophorphyrin IX binds to a transmembrane b-type cytochrome.
Topics: Cytochromes b; Heme; Iron; Magnesium; Models, Molecular; Protoporphyrins | 2014 |
Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.
Topics: Anemia; Animals; ATP-Binding Cassette Transporters; Erythroid Cells; Erythropoiesis; Heme; Iron; Mice; Mice, Inbred C57BL; Mitochondria; Protoporphyrins; Reticulocytes | 2014 |
In vitro conversion of vinyl to formyl groups in naturally occurring chlorophylls.
Topics: Catalysis; Chlorophyll; Chlorophyll A; Formates; Heme; Mercaptoethanol; Photosynthesis; Prochlorococcus; Protoporphyrins; Vinyl Compounds | 2014 |
TMEM14C is required for erythroid mitochondrial heme metabolism.
Topics: Anemia; Animals; Cell Line; Erythroid Cells; Erythropoiesis; Gene Expression Regulation; Heme; Hemoglobins; Liver; Membrane Proteins; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Porphyrins; Protoporphyrins; RNA, Small Interfering | 2014 |
Hemolysis-induced lethality involves inflammasome activation by heme.
Topics: Animals; Carrier Proteins; Caspase 1; Heme; Hemolysis; Humans; Inflammasomes; Interleukin-1beta; Macrophage Activation; Macrophages; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; NADPH Oxidase 2; NADPH Oxidases; NLR Family, Pyrin Domain-Containing 3 Protein; Potassium; Protoporphyrins; Reactive Oxygen Species | 2014 |
Orienting the heterocyclic periphery: a structural model for chloroquine's antimalarial activity.
Topics: Antimalarials; Chloroquine; Gallium; Heme; Models, Chemical; Molecular Structure; Protoporphyrins | 2014 |
Cutaneous mitochondrial respirometry: non-invasive monitoring of mitochondrial function.
Topics: Aminolevulinic Acid; Animals; Blood Gas Monitoring, Transcutaneous; Endotoxemia; Equipment Design; Healthy Volunteers; Heme; Humans; Lipopolysaccharides; Male; Mitochondria; Monitoring, Physiologic; Oxygen; Oxygen Consumption; Protoporphyrins; Rats; Rats, Wistar; Skin | 2015 |
The crimson conundrum: heme toxicity and tolerance in GAS.
Topics: Adaptation, Physiological; Bacterial Proteins; Bacterial Toxins; Erythrocyte Membrane; Genetic Loci; Heme; Hemolysin Proteins; Hemolysis; Lipid Peroxidation; Membrane Proteins; Phenotype; Protein Binding; Protoporphyrins; Sphingomyelin Phosphodiesterase; Streptococcal Infections; Streptococcus pyogenes; Stress, Physiological | 2014 |
The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Cation Transport Proteins; Cell Line, Tumor; Heme; Humans; Iron; MCF-7 Cells; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity | 2015 |
Mitochondrial function provides instructive signals for activation-induced B-cell fates.
Topics: Animals; B-Lymphocyte Subsets; Basic-Leucine Zipper Transcription Factors; Cell Differentiation; Cell Tracking; Gene Expression; Heme; Immunoglobulin Class Switching; Lymphocyte Activation; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Plasma Cells; Positive Regulatory Domain I-Binding Factor 1; Primary Cell Culture; Protoporphyrins; Reactive Oxygen Species; Signal Transduction; Stochastic Processes; Transcription Factors | 2015 |
Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy.
Topics: Aminolevulinic Acid; Caco-2 Cells; Cell Line, Tumor; Heme; Humans; K562 Cells; Kinetics; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; U937 Cells | 2015 |
Deconvoluting heme biosynthesis to target blood-stage malaria parasites.
Topics: Aminolevulinic Acid; Artemisinins; Biosynthetic Pathways; Erythrocytes; Heme; Humans; Lactones; Photosensitizing Agents; Plasmodium falciparum; Protoporphyrins; Reactive Oxygen Species | 2015 |
Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis.
Topics: Aminolevulinic Acid; Animals; Cell Death; Heme; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Mitochondria; Protoporphyrins; Receptors, GABA | 2016 |
Photoinactivation of Staphylococcus aureus using protoporphyrin IX: the role of haem-regulated transporter HrtA.
Topics: Adenosine Triphosphatases; Biological Transport; Heme; Light; Microbial Viability; Photosensitizing Agents; Protoporphyrins; Staphylococcus aureus | 2016 |
Formation of naturally occurring pigments during the production of nitrite-free dry fermented sausages.
Topics: Animals; Color; Fermentation; Heme; Humans; Hydrogen-Ion Concentration; Meat Products; Nitrates; Nitrites; Protoporphyrins; Zinc | 2016 |
Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis.
Topics: Animals; Antifungal Agents; Aspergillus nidulans; Bacteria; Cell Line; Drug Resistance, Fungal; Drug Synergism; Ferrochelatase; Fungi; Heme; Heterocyclic Compounds, 4 or More Rings; Humans; Insecta; Microbial Sensitivity Tests; Mycoses; Protoporphyrins | 2016 |
Differential Regulation of the Two Ferrochelatase Paralogues in Shewanella loihica PV-4 in Response to Environmental Stresses.
Topics: Bacterial Proteins; Ferrochelatase; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Heme; Iron; Protoporphyrins; Shewanella; Sigma Factor; Stress, Physiological | 2016 |
Homolytic Cleavage of Both Heme-Bound Hydrogen Peroxide and Hydrogen Sulfide Leads to the Formation of Sulfheme.
Topics: Animals; Bivalvia; Catalytic Domain; Heme; Hemoglobins; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen Sulfide; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protoporphyrins; Quantum Theory | 2016 |
Her2 oncogene transformation enhances 5-aminolevulinic acid-mediated protoporphyrin IX production and photodynamic therapy response.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Female; Heme; Humans; Levulinic Acids; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Receptor, ErbB-2; Signal Transduction | 2016 |
Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Female; Heme; Humans; Lasers, Semiconductor; Lighting; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Random Allocation; Siderophores; Skin Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
The HemQ coprohaem decarboxylase generates reactive oxygen species: implications for the evolution of classical haem biosynthesis.
Topics: Bacterial Proteins; Catalase; Coproporphyrinogen Oxidase; Coproporphyrins; Free Radicals; Heme; Horseradish Peroxidase; Hydrogen Peroxide; Models, Chemical; Protoporphyrinogen Oxidase; Protoporphyrins; Reactive Oxygen Species; Staphylococcus aureus; Superoxide Dismutase | 2016 |
Erythroid cell mitochondria receive endosomal iron by a "kiss-and-run" mechanism.
Topics: Animals; Biological Transport; Cell Differentiation; Endocytosis; Endosomes; Ferrochelatase; Fetus; Fluorescent Dyes; Heme; Humans; Iron; Liver; Mice; Mitochondria; Mutation; Primary Cell Culture; Protoporphyrins; Reticulocytes; Staining and Labeling; Transferrin | 2016 |
Over expression of 5-aminolevulinic acid synthase 2 increased protoporphyrin IX in nonerythroid cells.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Line, Tumor; Heme; Mice; Mice, Transgenic; Photosensitizing Agents; Protoporphyrins; Transfection | 2017 |
Transgenic Tobacco Lines Expressing Sense or Antisense FERROCHELATASE 1 RNA Show Modified Ferrochelatase Activity in Roots and Provide Experimental Evidence for Dual Localization of Ferrochelatase 1.
Topics: Down-Regulation; Ferrochelatase; Gene Expression Regulation, Plant; Heme; Mitochondria; Nicotiana; Organ Specificity; Phenotype; Plant Leaves; Plant Proteins; Plant Roots; Plants, Genetically Modified; Protein Transport; Protoporphyrins; RNA, Antisense | 2016 |
Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death.
Topics: Animals; Biosynthetic Pathways; Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Disease Models, Animal; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Heme; Humans; Mice; Photochemotherapy; Protoporphyrins; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2017 |
No changes in heme synthesis in human Friedreich´s ataxia erythroid progenitor cells.
Topics: Case-Control Studies; Cells, Cultured; Erythroid Precursor Cells; Erythropoiesis; Ferrochelatase; Frataxin; Friedreich Ataxia; Heme; Hemoglobins; Humans; Iron; Iron-Binding Proteins; Oxidative Stress; Protoporphyrins | 2017 |
Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite.
Topics: Aminolevulinic Acid; Anti-Bacterial Agents; Biosynthetic Pathways; Drug Resistance, Bacterial; Escherichia coli; Genome, Bacterial; Heme; Iron Deficiencies; Metalloids; Microbial Sensitivity Tests; Models, Biological; Mutation; Protoporphyrins; Superoxides; Tellurium | 2017 |
Strong Inhibitory Effect of Heme on hIAPP Fibrillation.
Topics: Circular Dichroism; Electrophoresis, Gel, Pulsed-Field; Heme; Humans; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Protein Binding; Protoporphyrins; Spectrometry, Fluorescence | 2017 |
Influence of meat source, pH and production time on zinc protoporphyrin IX formation as natural colouring agent in nitrite-free dry fermented sausages.
Topics: Animals; Color; Fermentation; Food Handling; Food Microbiology; Heme; Horses; Hydrogen-Ion Concentration; Meat Products; Protoporphyrins; Swine; Time Factors | 2018 |
PufQ regulates porphyrin flux at the haem/bacteriochlorophyll branchpoint of tetrapyrrole biosynthesis via interactions with ferrochelatase.
Topics: Aerobiosis; Anaerobiosis; Bacterial Proteins; Bacteriochlorophylls; Carotenoids; Coproporphyrinogens; Ferrochelatase; Heme; Heterotrophic Processes; Light-Harvesting Protein Complexes; Lyases; Mutation; Operon; Photosynthetic Reaction Center Complex Proteins; Phototrophic Processes; Protoporphyrins; Rhodobacter sphaeroides; Tetrapyrroles | 2017 |
Liaison between heme metabolism and bioenergetics pathways-a multimodal elucidation for early diagnosis of oral cancer.
Topics: 5-Aminolevulinate Synthetase; Adult; Aged; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cigarette Smoking; Down-Regulation; Early Detection of Cancer; Energy Metabolism; Female; Ferrochelatase; Gene Expression; Heme; Heme Oxygenase-1; Humans; Leukoplakia, Oral; Male; Middle Aged; Mouth Neoplasms; Neoplasms, Squamous Cell; Oxidation-Reduction; Protoporphyrins; Real-Time Polymerase Chain Reaction; RNA, Messenger; Spectroscopy, Fourier Transform Infrared; Up-Regulation | 2018 |
Characterization and origin of heme precursors in amniotic fluid: lessons from normal and pathological pregnancies.
Topics: Adult; Amniocentesis; Amniotic Fluid; Cell Differentiation; Coproporphyrins; Female; Heme; Humans; Ileus; Intestinal Atresia; Karyotyping; Maternal Age; Mitochondria; Oxidative Stress; Oxygen; Placenta; Porphyrias; Pregnancy; Prenatal Diagnosis; Protoporphyrins; Retrospective Studies; Uroporphyrins | 2018 |
Structure-activity relationship of heme and its analogues in membrane damage and inhibition of fusion.
Topics: Cell Membrane Permeability; Chloroquine; Fluoresceins; Heme; Hemin; Humans; Membrane Fusion; Membranes; Phospholipids; Protoporphyrins; Structure-Activity Relationship; Unilamellar Liposomes | 2018 |
Rapid Uptake and Photodynamic Inactivation of Staphylococci by Ga(III)-Protoporphyrin IX.
Topics: Fluorescence; Gallium; HEK293 Cells; Heme; Humans; Keratinocytes; Methicillin-Resistant Staphylococcus aureus; Microbial Viability; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Staphylococcus aureus | 2018 |
Ferrochelatase activity of plant frataxin.
Topics: Arabidopsis; Arabidopsis Proteins; Catalysis; Chloroplasts; Ferrochelatase; Heme; Iron-Binding Proteins; Mitochondria; Protoporphyrins | 2019 |
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Ferrochelatase; Heme; Hep G2 Cells; Hepatocytes; Humans; Hydrazines; Iron; Isoniazid; Liver; Mice, Inbred C57BL; Mice, Transgenic; Protoporphyrins; Pyridoxal; Rifampin; Vitamin B 6 | 2019 |
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Oxygen; Photosensitivity Disorders; Photosensitizing Agents; Porphyrias; Porphyrins; Protein Aggregates; Protein Conformation; Protoporphyrins | 2019 |
Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Dynamin II; Exocytosis; Heme; Humans; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Trimethyl Ammonium Compounds; Ultraviolet Rays | 2019 |
Differential gene content and gene expression for bacterial evolution and speciation of Shewanella in terms of biosynthesis of heme and heme-requiring proteins.
Topics: Bacterial Proteins; Cytochromes; Ecosystem; Ferrochelatase; Fresh Water; Gene Expression; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genotype; Glutathione Peroxidase; Heme; Hemeproteins; Iron; Phenotype; Protoporphyrins; Seawater; Shewanella | 2019 |
Probing Hexaminolevulinate Mediated PpIX Fluorescence in Cancer Cell Suspensions in the Presence of Chemical Adjuvants.
Topics: Aminolevulinic Acid; Biosynthetic Pathways; Cell Line, Tumor; Fluorescence; Heme; Humans; Molecular Imaging; Photosensitizing Agents; Protoporphyrins | 2020 |
Modulation of aminolevulinic acid-based photoinactivation efficacy by iron in vitro is cell type dependent.
Topics: Aminolevulinic Acid; Cell Line; Culture Media; Heme; Humans; Iron; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2020 |
Different effects of an N-phenylimide herbicide on heme biosynthesis between human and rat erythroid cells.
Topics: Animals; Benzoxazines; Cell Line, Tumor; Erythroid Cells; Female; Fetal Blood; Heme; Herbicides; Humans; Phthalimides; Pregnancy; Protoporphyrinogen Oxidase; Protoporphyrins; Rats, Sprague-Dawley; Species Specificity | 2021 |
Studies on the binding of nitrogenous bases to protoporphyrin IX iron(II) in aqueous solution at high pH values.
Topics: Ferrous Compounds; Heme; Hydrogen-Ion Concentration; Iron; Ligands; Nitrogen; Protoporphyrins | 2022 |
Analysis of Renal Cell Carcinoma Cell Response to the Enhancement of 5-aminolevulinic Acid-mediated Protoporphyrin IX Fluorescence by Iron Chelator Deferoxamine
Topics: Aminolevulinic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Deferoxamine; Fluorescence; Heme; Humans; Iron; Iron Chelating Agents; Kidney Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2023 |
A new member of the flavodoxin superfamily from Fusobacterium nucleatum that functions in heme trafficking and reduction of anaerobilin.
Topics: Bacterial Proteins; Biological Transport; Flavin Mononucleotide; Flavodoxin; Fusobacterium Infections; Fusobacterium nucleatum; Genes, Bacterial; Heme; Humans; Iron; Oxidation-Reduction; Protein Domains; Tetrapyrroles | 2023 |
A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin.
Topics: Aminolevulinic Acid; Animals; Cell Death; Heme; Mammals; Peroxiredoxins; Proteomics | 2023 |