Page last updated: 2024-08-16

protoporphyrin ix and aminolevulinic acid

protoporphyrin ix has been researched along with aminolevulinic acid in 860 studies

Research

Studies (860)

TimeframeStudies, this research(%)All Research%
pre-19907 (0.81)18.7374
1990's169 (19.65)18.2507
2000's311 (36.16)29.6817
2010's313 (36.40)24.3611
2020's60 (6.98)2.80

Authors

AuthorsStudies
Callan, JF; Jack, IG; Kavanagh, ON; Loan, P; McEwan, C; McHale, AP; McKenna, K; Nesbitt, H; Nicholas, D1
Kennedy, JC; Pottier, RH1
Arkins, S; Kelley, KW; Rebeiz, CA; Rebeiz, CC; Rebeiz, N1
Bedwell, J; Bown, SG; MacRobert, AJ; Phillips, D1
Febre, EF; Javor, GT1
Cox, TM; Gardner, LC; Smith, SJ1
Kennedy, JC; Pottier, RH; Pross, DC1
Divaris, DX; Kennedy, JC; Pottier, RH1
Cutler, MG; Mair, J; Moore, MR1
Arrol, S; Cutler, MG1
Kramer, S; Siepker, LJ1
Chambon, H; Labbe, P1
González Ramírez, JD; Molina-Ballesteros, G; Navarrete-Cadena, C; Zúñiga-Charles, MA1
Fukui, S; Isobe, N; Kamihara, T; Nakamura, I; Nakamura, N1
Novogrodsky, A; Rubin, AL; Stenzel, KH1
Lee, CJ; Lofgren, LA; Nouri, M; Ronn, AM; Steinberg, BM; Yoo, D1
Cairnduff, F; Roberts, DJ1
Brown, NJ; Leveckis, J; Reed, MW1
Abels, C; Bäumler, W; Fritsch, C; Goerz, G; Goetz, AE; Karrer, S; Landthaler, M; Steinbach, P; Szeimies, RM1
Hayashi, N1
Harada, K; Kim, Y; Ohmori, S; Tomokuni, K1
Ehrenberg, B; Kostenich, G; Malik, Z; Orenstein, A; Roitman, L1
Bown, SG; Conio, M; MacRobert, AJ; Messmann, H; Millson, CE; Mĺkvy, P; Pauer, M; Regula, J2
Bazin, M; Dubertret, L; Gaullier, JM; Gèze, M; Mazière, JC; Morlière, P; Sa e Melo, T; Santus, R1
Bown, SG; Buonaccorsi, G; Davies, CL; MacRobert, AJ; Messmann, H; Mlkvy, P1
Bown, SG; Grant, WE; Hopper, C; MacRobert, AJ; Speight, PM2
Greer, PA; Reid, RL; van Vugt, DA; Yang, JZ1
Berg, K; Luksiene, Z; Ma, L; Moan, J1
Hryhorenko, E; Morgan, J; Oseroff, AR; Paszkiewicz, G; Rittenhouse-Diakun, K; Van Leengoed, H; Whitaker, JE1
Forrer, M; Graber, P; Jichlinski, P; Leisinger, HJ; Mizeret, J; Schmidlin, F; Van den Bergh, H; Wagnière, G1
Matthews, EK; Ratcliffe, SL1
Bachor, R; Flotte, T; Hasan, T; Iinuma, S1
Andersson-Engels, S; Carlsson, K; Rokahr, I; Trepte, O1
Baumgartner, R; Ehsan, A; Hofstädter, F; Hofstetter, A; Knüchel, R; Kriegmair, M; Lumper, W; Steinbach, P1
Star, WM; van der Veen, N; van Leengoed, HL1
Baumgartner, R; Hofstädter, F; Knüchel, R; Kriegmair, M; Steinbach, P1
Berns, MW; Krasieva, T; Schell, M; Tadir, Y; Tromberg, BJ; Wyss, MT; Wyss, P1
Baumgartner, R; Ehsan, A; Hofstädter, F; Hofstetter, A; Knuechel, R; Kriegmair, M; Lumper, W; Steinbach, P1
Brown, NJ; Burn, JL; Leveckis, J; Reed, MW1
Farshi, SS; Hasan, T; Iinuma, S; Ortel, B1
Karu, T; Letokhov, V1
Bedwell, J; Bown, SG; MacRobert, AJ; Ravi, B; Regula, J1
Landthaler, M; Sassy, T; Szeimies, RM1
König, K; Rück, A; Schneckenburger, H; Steiner, R1
Ehret, W; Jacob, K; Luppa, P1
Anderson, RR; Deutsch, TF; Fewkes, JL; Flotte, TJ; Grevelink, JM; Martin, A; Starr, JC; Tope, WD1
Canti, G; Cubeddu, R; Taroni, P; Valentini, G1
de Brito, LX; Foultier, MT; Gouyette, A; Morlet, L; Patrice, T; Vonarx-Coinsman, V1
Baumgartner, R; Hofstädter, F; Knüchel, R; Kriegmair, M; Steinbach, P; Weingandt, H1
Banieghbal, E; Krammer, B; Uberriegler, KP1
Kennedy, JC; Reid, RL; Van Dijk-Smith, JP; Van Vugt, DA; Yang, JZ1
Campbell, DL; Campling, BG; Fisher, ME; Johnson, JG; Kennedy, JC; Pottier, RH; Rossi, FM1
Baumgartner, R; Ehsan, A; Hofstetter, A; Knüchel, R; Kriegmair, M; Lumper, W; Rick, K; Steinbach, P; Stepp, H; Stepp, HG1
Brown, SB; Gannon, MJ; Holroyd, JA; Johnson, N; Lilford, RJ; Roberts, DJ; Vernon, DI1
Berg, RJ; de Bruijn, HS; Star, WM; van der Veen, N1
Ehrenberg, B; Kopolovic, Y; Kostenich, G; Malik, Z; Orenstein, A; Roitman, L; Shechtman, Y1
Bown, SG; Chang, SC; MacRobert, AJ1
Fromm, D; Kessel, D; Webber, J4
Reinbothe, C; Reinbothe, S1
Berg, K; Nesland, JM; Noodt, BB; Peng, Q; Stokke, T1
Bown, SG; Kleemann, D; MacRobert, AJ; Mentzel, T; Speight, PM1
Bolsen, K; Dickson, E; Dietel, W; Fritsch, C; Pottier, R; Wendenburg, R1
Berns, MW; Haller, U; Kurlawalla, CS; Sun, CH; Tadir, Y; Wyss, P; Wyss-Desserich, MT1
Collins, P; Robinson, DJ; Sheehan-Dare, RA; Stables, GI; Stringer, MR2
Barr, H; Dix, A; Krasner, N; Roberts, DJ; Shepherd, NA; Tan, WC1
Anholt, H; Bech, O; Berg, K; Moan, J1
Berg, K; Chekulayev, V; Moan, J; Shevchuk, I1
Campbell, DL; Dickson, EF; Kennedy, JC; Pottier, RH; Rossi, FM1
Berns, MW; Svaasand, LO; Tadir, Y; Tromberg, BJ; Wyss, MT; Wyss, P1
Campbell, DL; Forkert, PG; Gudgin-Dickson, EF; Kennedy, JC; Pottier, RH1
Bachor, R; Hautmann, R; Reich, E; Rück, A1
Andersson-Engels, S; Liu, DL; Stenram, U; Svanberg, K; Svanberg, S; Wang, I1
DiSaia, PJ; Fehr, MK; Krasieva, T; Lin, F; Tadir, Y; Tromberg, BJ; Wyss, P1
Anderson, RR; Kollias, N; Rhodes, LE; Tsoukas, MM1
Gederaas, OA; Romslo, I; Thorstensen, K1
Bagdonas, S; Bech, O; Berg, K; Moan, J; Streckyte, G1
Alwin, G; Baumgartner, R; Feyh, J; Gutmann, R; Leunig, A; Rick, K; Stepp, H1
Krammer, B; Uberriegler, K1
Baumgartner, R; Gamarra, F; Huber, RM; Leberig, A; Rick, K; Roth, C; Schulz, H; Stepp, H1
Bech, O; Berg, K; Moan, J1
Berg, K; Kongshaug, M; Moan, J; Nesland, JM; Peng, Q1
Andersson-Engels, S; Berg, R; Heyerdahl, H; Liu, DL; Moan, J; Peng, Q; Svanberg, K; Svanberg, S; Wang, I1
Forrer, M; Graber, P; Guillou, L; Jichlinski, P; Leisinger, HJ; Mizeret, J; Oswald, M; Schmidlin, F; Van den Bergh, H; Wagnières, G1
Anholt, H; Berg, K; Gaullier, JM; Ma, LW; Moan, J; Peng, Q; Selbo, PK1
Bown, SG; Buonaccorsi, G; Chang, SC; MacRobert, AJ1
Berg, R; Johansson, J; Svanberg, K; Svanberg, S1
Braichotte, D; Forrer, M; Glanzmann, T; Graber, P; Guillou, L; Jichlinski, P; Leisinger, HJ; Mizeret, J; Schmidlin, F; van den Bergh, H; Wagnières, G; Zimmer, G1
Forrer, M; Graber, P; Guillou, L; Jichlinski, P; Leisinger, HJ; Mizeret, J; Schmidlin, F; Van den Bergh, H; Wagniéres, G1
Riley, PA; Washbrook, R1
Berg, K; Giercksky, KE; Kongshaug, M; Moan, J; Nesland, JM; Peng, Q; Warloe, T1
Bown, SG; Chang, SC; MacRobert, AJ; Porter, JB1
Baumgartner, R; Heil, P; Sroka, R; Stocker, S1
Alhava, E; Grönlund-Pakkanen, S; Kuusisto, A; Mäkinen, K; Talja, M1
Bazin, M; Dubertret, L; Gaullier, JM; Giraud, M; Santus, R; Valla, A1
De Bruijn, HS; Star, WM; Van der Veen, N1
Bown, SG; Buonaccorsi, GA; Chang, SC; MacRobert, AJ1
Bechara, EJ; Costa, CA; Pinto, AM; Trivelato, GC1
Berns, MW; Chapman, CF; DiSaia, PJ; Haller, U; Hiserodt, JC; Krasieva, TB; Major, AL; Rose, GS; Tadir, Y; Tromberg, BJ1
Alhava, E; Grönlund-Pakkanen, S; Kuusisto, A; Mäkinen, K; Nuutinen, P; Tiirikainen, M1
Carre, J; Eleouet, S; Gouyette, A; Ioss, P; Lajat, Y; Leray, AM; Merle, C; Patrice, T; Vonarx, V1
Krasner, N; Lombard, M; O'Toole, P; Tan, WC1
Baumgartner, R; Fuchs, C; Riesenberg, R; Siegert, J1
Brown, NJ; Burn, JL; Reed, MW; Wyld, L1
Abels, C; Doss, M; Geisler, M; Gross, U; Holstege, A; Knüchel, R; Messmann, H; Schölmerich, J; Steinbach, P; Szeimies, RM1
Fromm, D; Herman, MA; Kessel, D; Luo, Y; Patacsil, V; Webber, J1
Matovic, V; Plamenac, Z; Soldatovic, D; Vujanovic, D1
Baumgartner, R; Huber, RM; Jacob, K; Kriegmair, M; Rick, K; Sroka, R; Stepp, H1
Hamblin, MR; Hasan, T; Momma, T1
Anderson, RR; Crum, C; Kollias, N; Romero, R; Ross, EV1
Bech, O; Berg, K; Gaullier, JM; Ma, LW; Moan, J; Steen, HB; Stokke, T1
Futsaether, CM; Johnsson, A; Ramstad, S1
Carré, J; Eléouet, S; Heyman, D; Lajat, Y; Patrice, T; Vonarx, V1
Pottier, RH; Reid, RL; Roy, BN; Van Vugt, DA; Weagle, GE1
Bech, O; MacRobert, AJ; Moan, J; Phillips, D1
Brown, SB; de Bruijn, HS; Robinson, DJ; Star, WM; Stringer, MR; van der Veen, N2
Akkermans, W; Beijersbergen van Henegouwen, GM; Kloek, J1
Carroll, RL; Golub, AL; Lundahl, S; Marcus, SL; Shulman, DG; Sobel, RS1
Anderson, RR; Gillies, R; Kollias, N; Martin, A; Ross, EV; Tope, WD1
Lochs, H; Ortner, M1
Bäumler, W; Endlicher, E; Hauser, T; Knüchel, R; Kullmann, F; Messmann, H; Schölmerich, J; Szeimies, RM1
Kennedy, JC; Marcus, SL; Pottier, RH1
Harvey, NS; Hryhorenko, EA; Morgan, J; Oseroff, AR; Rittenhouse-Diakun, K; Stewart, CC1
Brown, KM; Lown, JW; McCallum, TJ; Miller, GG; Moore, RB; Tulip, J; Xiao, Z1
Brown, NJ; Reed, MW; Wyld, L1
Fromm, D; Herman, MA; Kessel, D; Webber, J1
Brown, NJ; Lawry, J; Reed, MW; Smith, O; Wyld, L1
Brissette, J; Chen, N; Dotto, GP; Hasan, T; Maytin, E; Ortel, B1
Adesokun, A; Chakrabarti, P; Egger, N; Gangula, R; Motamedi, M; Neal, DE; Orihuela, E1
de Rooij, FW; Edixhoven, A; Hinnen, P; Siersema, PD; Tilanus, HW; van Hillegersberg, R; van Velthuysen, ML; Wilson, JH1
de Bruin, RW; de Rooij, FW; Edixhoven-Bosdijk, A; Houtsmuller, AB; Siersema, PD; Tilanus, HW; van den Boogert, J; van Hillegersberg, R; Wilson, JH1
Iani, V; Ma, L; Moan, J; Peng, Q1
Bishop, CC; Bown, SG; Buonaccorsi, G; Jenkins, MP; MacRobert, A; McEwan, JR1
Ehrhardt, A; Leonhard, M; Möller, G; Reulen, HJ; Stepp, H; Stummer, W1
Hryhorenko, EA; Morgan, J; Oseroff, AR; Rittenhouse-Diakun, K1
Iani, V; Moan, J; Sørensen, R1
Krammer, B; Schnitzhofer, G; Verwanger, T1
Heimann, A; Kempski, O; Novotny, A; Plesnila, N; Reulen, HJ; Sauer, O; Stocker, S; Stummer, W; Wietzorrek, J1
Barth, T; Haase, T; Kübler, A; Mühling, J; Rheinwald, M1
Bäumler, W; Holstege, A; Knüchel, R; Messmann, H; Schölmerich, J1
Bartosová, J; Cajthamlová, H; Fuchs, O; Grebenová, D; Hrkal, Z; Klamová, H; Marinov, J1
de Bruin, RW; Siersema, PD; Tilanus, HW; van Dekken, H; van den Boogert, J; van Hillegersberg, R; van Staveren, HJ1
Cardoso, E; Clemente, LP; Clemente, MP; Montán, S; Pratas, RM; Svanberg, K; Svanberg, S; Wang, I1
Gudmundson, F; Larko, O; Mölne, L; Rosén, A; Stenquist, B; Ternesten, A; Wennberg, AM1
Geiger, PG; Girotti, AW; Korytowski, W; Lin, F1
Fraikin, GY; Ivanova, EV; Kolesnikova, OA; Strakhovskaya, MG1
Foster, TH; Georgakoudi, I; Keng, PC1
Kvam, E; Pourzand, C; Reelfs, O; Tyrrell, RM1
Iani, V; Juzenas, P; Moan, J; Sørensen, R1
Popken, G; Schultze-Seemann, W; Wetterauer, U1
Abels, C; Botzlar, A; Goetz, AE; Langer, S; Pahernik, S; Rick, K; Szeimies, RM1
Johnson, JG; Kennedy, JC; Li, G; Pottier, RH; Raptis, L; Szewczuk, MR; Weagle, GE1
Gibson, SL; Havens, JJ; Hilf, R; Nguyen, ML1
Forrer, M; Guillou, L; Jichlinski, P; Kucera, P; Lange, N; Marti, A; van den Bergh, H; Wagnières, G; Zellweger, M1
af Klinteberg, C; Andersson-Engels, S; Enejder, AM; Svanberg, K; Svanberg, S; Wang, I1
Berg, K; Dubbelman, TM; Gederaas, OA; Lagerberg, JW; Rasch, MH1
Batlle, AM; Brown, EH; Butler, AR; Casas, A; MacRobert, A; Riley, PA; Robertson, D1
Jichlinski, P; Kucera, P; Lange, N; Marti, A; Sedmera, D; van den Bergh, H1
Al-Batran, SE; Astner, ST; Brueckner, K; Gamarra, F; Huber, RM; Knuechel, R; Supthut, M; Welsch, U1
Hahn, EG; Hochberger, J; Mayinger, B; Reh, H1
Carre, J; Eleouet, S; Heyman, D; Lajat, Y; Patrice, T; Rousset, N; Vonarx, V1
Csik, G; Fidy, J; Gabor, F; Szocs, K1
Baumgartner, R; Hofstetter, A; Knuechel, R; Kriegmair, M; Zaak, D1
Dietel, W; Günzel, S; Schleier, P; Zenk, W1
Gibson, SL; Havens, JJ; Hilf, R1
Ackroyd, R; Brown, N; Marcus, S; Reed, M; Roberts, D; Stephenson, T; Stoddard, C; Vernon, D1
Berg, K; Gadmar, OB; Iani, V; Juzenas, P; Ma, L; Moan, J1
Barbarin, A; Gibson, SL; Havens, JJ; Hilf, R; Nguyen, ML1
Edwards, BF; Griffey, SM; Krasieva, TB; Lucroy, MD; Madewell, BR; Peavy, GM; Stiles, JB1
Anderson, LT; Gibson, SL; Havens, JJ; Hilf, R1
af Klinteberg, C; Andersson-Engels, S; Canti, G; Cubeddu, R; Eker, C; Pifferi, A; Svanberg, K; Svanberg, S; Taroni, P; Valentini, G; Wang, I1
Arbogast, S; Baumgartner, R; Betz, CS; Grevers, G; Leunig, A; Mehlmann, M; Stepp, H1
Bentley, MV; De Rosa, FS; Marchetti, JM; Tedesco, AC; Thomazini, JA1
Böhm, J; Gahlen, J; Herfarth, C; Holle, R; Pressmar, J; Stern, J1
Juillerat-Jeanneret, L; Lange, N; Uehlinger, P; van den Bergh, H; Wagnières, G; Zellweger, M1
Grimm, B; Mock, HP; Papenbrock, J; Pfündel, E1
Egger, NG; Flores, P; Fossum, TW; Jacques, SL; Motamedi, M; Rastegar, S; Vaidyanathan, VV; van Der Breggen, EW1
Carré, J; Eléouet, S; Lajat, Y; Louët, C; Patrice, T; Rousset, N; Vilatte, C; Vonarx, V1
Ala-Opas, M; Alhava, E; Grönlund-Pakkanen, S; Kosma, VM; Pakkanen, TM; Talja, M1
Wang, KK1
Barr, H1
Messmann, H1
Hirschberg, H; Madsen, SJ; Sun, CH; Tromberg, BJ; Wallace, VP1
Haik, J; Kostenich, G; Malik, Z; Orenstein, A; Tamir, J; Trau, H; Winkler, E1
Allman, R; Cowburn, P; Mason, M1
de Rooij, FW; Edixhoven, A; Hinnen, P; Siersema, PD; Terlouw, EM; Tilanus, HW; van Dekken, H; van Hillegersberg, R; Wilson, JH1
Bagdonas, S; Iani, V; Juzenas, P; Ma, LW; Moan, J; Rotomskis, R1
Birkel, M; Popken, G; Schultze-Seemann, W; Seiler, KU; Wetterauer, U1
Belicková, M; Brdicka, R; Bruchová, H; Cajthamlová, H; Hrkal, Z1
Beijersbergen van Henegouwen, GM; de Bruijn, HS; Star, WM; Sterenborg, HJ; van den Akker, JT1
Baumgartner, R; Betz, CS; Grevers, G; Issing, WJ; Leunig, A1
Lilge, L; Portnoy, M; Wilson, BC1
Matthews, EK; Mesenhöller, M1
Brown, SB; Connelly, JP; Gerscher, S; Griffiths, J; MacRobert, AJ; Rhodes, LE; Wong, G1
Bartosová, J; Hrkal, Z1
Battah, SH; Boyle, RW; Edwards, C; Forsyth, MJ; Matthews, EK; Whitaker, CJ1
Edixhoven-Bosdijk, A; Siersema, PD; van Den Boogert, J; van Hillegersberg, R; van Staveren, HJ1
Frimberger, D; Hofstetter, A; Zaak, D1
Iani, V; Moan, J; Star, WM; Sterenborg, HJ; van den Akker, JT2
Berger, Y; Greppi, A; Juillerat-Jeanneret, L; Neier, R; Siri, O1
Beger, HG; Orth, K; Russ, D; Steiner, R1
de Bruijn, HS; de Wolf, WJ; Robinson, DJ; Star, WM; Sterenborg, HJ1
Conover, DL; Finlay, JC; Foster, TH; Hull, EL1
Manohara, MS; Tripathy, BC1
Bown, SG; Curnow, A; Haller, JC1
Iani, V; Ma, LW; Moan, J1
Klein, SD; Ladner, DP; Steiner, RA; Walt, H1
Dubois, J; Duez, P; Hanocq, M1
Killig, F; Kunz, L; Stark, G1
Bezdetnaya, L; Cosserat-Gerardin, I; Guillemin, F; Notter, D; Vigneron, C1
Appel, S; Baumgartner, R; Knuechel, R; Krieg, RC; Rauch, J; Seidl, J1
Beijersbergen Van Henegouwen, GM; Connelly, JP; Gerscher, S; MacRobert, AJ; Rhodes, LE; Watt, P1
Etter, AL; Gerber, P; Jichlinski, P; Kucera, P; Lange, N; Marti, A; van Den Bergh, H; Vaucher, L1
Arbogast, S; Baumgartner, R; Betz, C; Grevers, G; Leunig, A; Mehlmann, M; Stepp, H1
Eggen, I; Luksiene, Z; Moan, J; Nesland, JM; Peng, Q1
Arkins, S; Durack, G; Kelley, KW; Rebeiz, CA; Rebeiz, N1
Hashimoto, K; Li, W; Ohnishi, K; Ohno, R; Yamada, I; Zhang, WJ1
Bagdonas, S; Ma, L; Moan, J1
Dickson, EF; Fischer, F; Pottier, RH; Wieland, H1
Dickson, EF; Fischer, F; Kennedy, JC; Pottier, RH1
de Blois, AW; de Bruijn, HS; Dutrieux, RP; Grouls, RJ; Neumann, HA; Robinson, DJ; Thissen, MR1
Bagdonas, S; Iani, V; Juzenas, P; Moan, J; Rotomskis, R1
de Bruin, RW; Siersema, PD; van den Boogert, J; van Hillegersberg, R; van Staveren, HJ1
Bigelow, CE; Foster, TH; Knuechel, R; Mitra, S1
Ishibashi, A; Itoh, Y; Ninomiya, Y; Tajima, S1
Berg, K; Kaalhus, O; Selbo, PK; Sivam, G1
Aalders, MC; Star, WM; Sterenborg, HJ; van der Vange, N1
Bissonnette, R; Korbelik, M; Lui, H; McLean, DI; Zeng, H1
Baumgartner, R; Frimberger, D; Hofstetter, A; Knüchel, R; Schmeller, N; Schneede, P; Stepp, H; Zaak, D1
Flechtenmacher, C; Gahlen, J; Herfarth, C; Prosst, RL; Winkler, S1
Hahn, EG; Martus, P; Mayinger, B; Neidhardt, S; Reh, H1
Baumgartner, R; Hillemanns, P; Klein, S; Liessmann, F; Stepp, H; Weingandt, H; Xiang, W1
Chai, SE; Choi, HY; Hong, JH; Jeon, SS; Kang, I1
Chopra, V; Dreher, E; Egger, N; Hawkins, HK; Motamedi, M; Schneider, H; Spörri, S1
Endlicher, E; Hausmann, F; Knüchel, R; Krieg, R; Messmann, H; Rath, HC; Rümmele, P; Schölmerich, J1
Brunner, H; Endlicher, E; Hausmann, F; Knuechel, R; Krieg, RC; Messmann, H; Schölmerich, J1
Chen, JY; Cheung, NH; Leung, RN; Mak, NQ; Peng, Q1
Batlle, A; Butler, AR; Casas, A; Fukuda, H; Perotti, C; Rogers, L1
Kaneko, S1
Arbogast, S; Baumgartner, R; Betz, CS; Grevers, G; Janda, P; Leunig, A; Stepp, H1
Iani, V; Juzenas, P; Löfgren, L; Ma, LW; Moan, J; von Beckerath, M1
Gahlen, J; Haase, T; Herfarth, C; Pietschmann, M; Prosst, RL; Rheinwald, M; Skopp, G; Stern, J1
Inokuchi, H; Kanjo, N; Nakahigashi, K; Oeda, K1
de Blois, MW; de Bruijn, HS; Dutrieux, RP; Neumann, HA; Robinson, DJ; Star, WM; Thissen, MR1
Bourre, L; Briffaud, A; Lajat, Y; Patrice, T; Thibaut, S1
Biel, AJ; Canada, K; Huang, D; Indest, K; Sullivan, K1
Ala-Opas, M; Alhava, E; Gronlund-Pakkanen, S; Makinen, K; Moore, RB; Pakkanen, TM; Talja, M; Wahlfors, J1
Deutsch, TF; Duska, LR; Haas, J; Hasan, T; Houck, K; Ortel, B; Wimberly, J1
Brown, NJ; Reed, MW; Tomlinson, M; Wyld, L1
Dalton, JT; Golub, AL; Marcus, SL; Meyer, MC; Straughn, A; Yates, CR; Yin, D1
Aalders, MC; Bogaards, A; Dannecker, C; de Blok, S; Hillemanns, P; Stepp, H; Sterenborg, HJ; Zeyl, CC1
Bourré, L; Eléouet, S; Lajat, Y; Patrice, T; Rousset, N; Thibaut, S1
Chen, IH; Lo, YL; Tsai, JC; Wong, TW1
Aalders, MC; Sac, A; Star, WM; Sterenborg, HJ1
Bissonnette, R; Juzenas, P; Moan, J; Sharfaei, S2
Ell, C; Gossner, L; May, A; Nagy, CD; Pech, O1
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Hagiya, Y; Inoue, K; Kobayashi, T; Matsumoto, K; Nakajima, M; Nakayama, T; Ogura, SI; Okajima, H; Otsuka, S; Shuin, T; Tanaka, T1
Cheng, J; Dong, Z; Guo, Y; Li, Z; Shi, Y; Sun, J; Sun, X; Tian, Y; Tian, Z; Wang, L; Wang, W; Yao, J1
Bouvier, G; Comby, P; Gaborit, A; Hanaizi, J; Kouidhi, M; Osman-Ponchet, H; Ruty, B; Sevin, K1
Bettink, MAW; Harms, FA; Janse, R; Johannes, T; Mik, EG; Münker, FM; Ubbink, R1
Gerelli, E; Joniová, J; Wagnières, G; Zellweger, M1
Fahey, JM; Girotti, AW1
Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J1
Dailey, HA; Dailey, TA; Gerdes, S; Jahn, D; Jahn, M; O'Brian, MR; Warren, MJ1
Bay, C; Ferrick, B; Haedersdal, M; Lerche, CM; Philipsen, PA; Togsverd-Bo, K1
Inoue, K1
Bierman, D; Gandy, J; Labadie, B; Zachary, C1
Borwege, S; Chen, Y; Liu, JTC; Sanai, N; Wei, L; Yin, C1
Allémann, E; Babič, A; Herceg, V; Lange, N1
Arenas, FA; Cornejo, FA; Luraschi, R; Morales, EH; Mori, H; Muñoz-Villagrán, CM; Myers, CL; Nelson, J; Pinto, CA; Piotrowski, JS; Simpkins, SW; Vásquez, CC1
Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE1
Hamblin, MR; Li, Y; Wen, X1
Kawahara, R; Kawakami, Y; Matsumoto, T; Nagano, N; Nagata, M; Nakaya, H; Nishizawa, T; Oana, K1
Chen, Y; Eubanks, JH; Fisher, CJ; Foltz, W; Lilge, L; Niu, C; Sidorova-Darmos, E1
Bravo, JJ; Davis, SC; Kanick, SC; Olson, JD; Paulsen, KD; Roberts, DW1
Ding, C; Fan, D; Ji, Z; Kang, Q; Liu, J; Ning, S; Peng, Q; Xue, C; Zhang, J; Zhang, X1
Chen, ZL; Gao, YH; Han, YP; Lu, ZB; Namulinda, T; Song, CH; Wang, LX; Yan, YJ; Zhu, W1
Furuse, M; Ikeda, N; Kajimoto, Y; Katayama, Y; Kawabata, S; Kuroiwa, T; Nonoguchi, N; Yagi, R1
Chapman, MS; Davis, SC; de Souza, ALR; Gunn, J; Hasan, T; LaRochelle, E; Marra, K; Maytin, EV; Pogue, BW; Samkoe, KS1
Akter, S; Awazu, K; Fuse, S; Hazama, H; Honda, N; Inai, M; Kaneda, Y; Nakamura, H; Nishikawa, T1
Collins, P; Gray, L; Manley, M; McCavana, J; O'Gorman, S1
Heerfordt, IM; Wulf, HC1
Ishii, T; Ishizuka, M; Kajiyama, H; Kikkawa, F; Kitajima, Y; Mizuno, M; Sakata, J; Shibata, K; Teshigawara, T; Utsumi, F1
Falco, A; Mallavia, R; Mateo, CR; Mira, A1
Corrêa, L; Pelissari, C; Rosin, FCP; Teixeira, MG1
Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM1
Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC1
Iwahashi, H; Mori, T; Murakami, M; Takahashi, J1
Christensen, E; Darvekar, SR; Gederaas, OA; Holien, T; Peng, Q1
Bieliauskiene, G; Heerfordt, IM; Wulf, HC1
Anai, S; Fujimoto, K; Hori, S; Miyake, M; Morizawa, Y; Nakai, Y; Onisi, S; Tanaka, N; Tatsumi, Y1
Barlier, C; Bezdetnaya, L; Dolivet, G; Francois, A; Leufflen, L; Marchal, F; Salleron, J1
Cao, W; Cao, Z; Cheng, J; Dan, J; Guo, S; Sun, X; Tian, F; Tian, Y; Wang, W1
Dong, X; Fan, JX; Liu, XH; Pan, P; Xu, L; Zhang, XZ; Zheng, DW1
Bánó, G; Gerelli, E; Joniová, J; Kažiková, V; Wagnières, G1
Wang, B; Wang, P; Wang, X; Wu, Y; Zhang, L1
Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J1
Belykh, E; Bozkurt, B; Lawton, MT; Miller, EJ; Nakaji, P; Nelson, LY; Patel, AA; Preul, MC; Robinson, TR; Seibel, EJ; Spetzler, RF; Yağmurlu, K1
Friebe, M; Goeppner, D; Gollnick, H; Illanes, A; Landes, R1
Aoki, D; Banno, K; Kisu, I; Matoba, Y1
Jeibmann, A; Karst, U; Kröger, S; Niehoff, AC; Paulus, W; Sperling, M; Stummer, W1
Alston, L; Hebert, M; Mahieu-Williame, L; Montcel, B; Rousseau, D1
Backeris, P; Bishop, DF; D'Souza, S; Desnick, RJ; Katz, S; Lemischka, IR; Merck, C; Moore, K; Suprun, M; Ubarretxena-Belandia, I1
Fujita, H; Masujima, T; Mizuno, H; Oka, T; Sakata, M; Utsumi, K; Utsunomiya, A; Yamano, Y; Yoshino, T1
Hou, G; Ji, L; Qian, J; Suo, A; Wang, J; Wang, Y; Xu, W; Yang, M1
Beez, T; Briel-Pump, A; Ebbert, L; Remke, M; Sabel, MC; Sorg, RV; Weinhold, S1
Curnow, A; Perry, A; Wood, M1
Chen, L; Gao, L; Gao, X; Huang, X; Li, N; Lin, S; Song, Y; Wang, X; Zhang, X1
Cooper, JB; Endo, T; Schmidt, MH; Tominaga, T; Wainwright, JV1
Millesi, M; Roberts, DW; Valdes, PA; Widhalm, G1
Fujimoto, K; Hiroyuki, N; Matsuda, R; Motoyama, Y; Murakami, T; Nakagawa, I; Nakai, Y; Nakamura, M; Nakazawa, T; Nishimura, F; Omoto, K; Shida, Y; Tanaka, Y; Tatsumi, Y1
He, Q; He, W; Liu, P; Ren, J; Wang, J; Xiong, Y; Xu, Z; Yang, Z; Zhu, W1
Braun, A; Chen, B; Howley, R; Kraus, D; Mansi, M; Myers, KA; Palasuberniam, P1
Carrasco, E; Damian, A; Delgado-Wicke, P; Juarranz, Á; Lucena, SR; Mascaraque, M1
Wulf, HC1
Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N1
Ebihara, Y; Hirano, S; Hirohashi, Y; Kanaseki, T; Kawai, N; Kubo, T; Li, L; Murai, A; Nakatsugawa, M; Saito, T; Shichinohe, T; Shirosaki, T; Torigoe, T; Tsukahara, T1
Kaneko, S; Stummer, W; Suero Molina, E1
Buchner, A; Gederaas, OA; Pohla, H; Pongratz, T; Rühm, A; Shi, L; Sroka, R; Stepp, H; Wang, X; Zhang, L; Zimmermann, W1
Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H1
Dan, S; Ishii, T; Ishizuka, M; Kitajima, Y; Kohda, T; Nakajima, M; Nishimura, Y; Tanaka, T; Yamazaki, K1
Lai, HW; Nakajima, M; Ogura, SI; Sasaki, R; Tanaka, T; Usuki, S1
Champeau, M; Mordon, S; Mortier, L; Vignoud, S1
Cornelius, JF; Dibué-Adjei, M; Kamp, MA; Knipps, J; Mijderwijk, HJ; Neumann, LM; Rapp, M; Sabel, M; Slotty, PJ; Steiger, HJ1
Cornelius, JF; Dibué-Adjei, M; Fischer, I; Freiin von Saß, C; Kamp, MA; Knipps, J; Mijderwijk, HJ; Neumann, LM; Placke, JM; Rapp, M; Sabel, M; Steiger, HJ1
Harada, Y; Kumamoto, Y; Morita, M; Nakamura, A; Ogata, T; Sakaguchi, K; Taguchi, T; Takamatsu, T; Tanaka, H1
Chan, KM; Gleadle, J; Li, J; MacGregor, M; McNicholas, K; Shirazi, HS; Vasilev, K1
Gleadle, JM; MacGregor, MN; McNicholas, K1
Brentrup, A; Kaneko, S; Köchling, M; Müther, M; Schipmann, S; Schwake, M; Stummer, W; Suero Molina, E1
Gawecki, R; Malarz, K; Mrozek-Wilczkiewicz, A; Polanski, J; Rejmund, M1
Ishizuka, M; Okamoto, Y; Osaki, T; Takahashi, K; Tanaka, T1
Bagnato, VS; Fortunato, TC; Pratavieira, S; Requena, MB; Russignoli, PE; Salvio, AG; Vollet-Filho, JD1
Burgio, F; D'Angelo, ML; Kaelin-Lang, A; Paganetti, P; Piffaretti, D; Reinert, M; Thelen, M1
Bilmin, K; Grieb, P; Kujawska, T1
Chapman, MS; Gunn, JR; Hasan, T; Hull, SM; LaRochelle, EPM; Pogue, BW; Ruiz, AJ1
Maliszewska, I; Wanarska, E; Wawrzyńczyk, D1
Alston, L; Brevet, PF; Frindel, C; Guyotat, J; Leclerc, P; Mahieu-Williame, L; Meyronet, D; Montcel, B; Ray, C; Rousseau, D1
Foged, C; Haedersdal, M; Philipsen, PA; Togsverd-Bo, K; Wulf, HC1
Jeibmann, A; Stögbauer, L; Stummer, W; Suero Molina, E; Warneke, N1
Harada, Y; Koshiishi, N; Matsumoto, T; Matsuo, H; Murayama, Y; Okochi, K; Otsuji, E; Takamatsu, T; Tanaka, H1
Awazu, K; Hazama, H; Ihara, D; Morita, Y; Nishimura, T1
Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J1
Doi, M; Hasegawa, T; Iwahashi, H; Moriyama, A; Nagasawa, S; Takahashi, J1
Asakura, T; Higuchi, T; Morita, A; Oishi, Y; Yamaguchi, F; Yoshida, D1
Chan, KM; Gleadle, J; MacGregor, M; Vasilev, K1
Bagnato, VS; Moriyama, LT; Stringasci, MD; Vollet-Filho, JD1
Chu, ESM; Wu, RWK; Yow, CMN1
Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N1
Brebi, P; Buchegger, K; Ili, C; Kurachi, C; León, D; Mora-Lagos, B; Riquelme, I; Roa, JC; Schafer, F; Silva, R; Viscarra, T; Zanella, L1
Imanparast, A; Sazgarnia, A; Shayesteh Ara, E; Soudmand, S; Vejdani Noghreiyan, A; Vejdani Noghreiyan, V1
Jang, W-; Jung, S; Jung, T-; Kim, I-; Kim, J-; Kim, S-; Lee, K-; Moon, K-1
Champeau, M; Jary, D; Mordon, S; Mortier, L; Vignoud, S1
Abdel Gaber, SA; Müller, P; Stepp, H; Wittig, R; Zimmermann, W1
Lai, HW; Nakayama, T; Ogura, SI1
Chen, B; Howley, R; Mansi, M; Restrepo, J; Shinde, J2
Bagnato, VS; De Faria, CMG; Donnelly, RF; Garcia, MR; González-Vázquez, P; Permana, AD; Pratavieira, S; Requena, MB; Vollet-Filho, JD1
Cumberbatch, N; Holland, A; Hungerford, G; Sagoo, K1
Bik, L; Dierickx, C; Foged, C; Haedersdal, M; Phillipsen, PA; Togsverd-Bo, K1
Čunderlíková, B; Jerigová, M; Kalafutová, A; Teplický, T1
Bagnato, VS; Buzza, HH; Ciol, H; Inada, NM; Leite, IS; Romano, RA; Stringasci, MD1
Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A1
Bardonova, L; Belykh, E; Eschbacher, JM; George, LL; Georges, JF; Healey, DR; Jubran, JH; Mehta, S; Nakaji, P; Preul, MC; Quarles, CC; Scheck, AC1
Dondi, R; Eggleston, IM; MacRobert, AJ; Pourzand, C; Tewari, KM; Yaghini, E1
Borowska, K; Kaczorowska, A; Kałas, W; Kopaczyńska, M; Malinga-Drozd, M; Wołowiec, S1
Awazu, K; Hazama, H; Ogbonna, SJ1
Chan, KM; Gleadle, J; Li, J; MacGregor, M; Michl, TD; Vasilev, K1
Lai, HW; Nakajima, M; Ogura, SI; Takahashi, K; Tanaka, T1
Courrol, LC; de Oliveira Silva, FR; Masilamani, V1
Banerjee, R; Maitra, D; Omary, MB; Pinsky, BM; Soherawardy, A; Zheng, H1
Harms, FA; Mik, EG1
Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E1
Curnow, A; Magnussen, A; Perry, A; Reburn, C; Wood, M1
Fujihara, T; Fujiwara, Y; Kitazato, K; Matsuzaki, K; Mizobuchi, Y; Nakajima, K; Sampetrean, O; Saya, H; Shono, K; Takagi, Y; Uto, Y; Yamaguchi, I1
Chen, Q; Cheng, Y; He, H; Huang, P; Li, Y; Wei, W; Xiong, L; Yi, W; Zeng, L; Zou, Q1
Ashraf, S; Feng, Y; Hasan, T; Khalid, A; Kuriakose, J; Palanisami, A1
Essmann, F; Gillissen, B; Kemmner, W; Richter, A1
Agyapong, J; Ashraf, S; Hasan, T; Rohrbach, P1
Braun, A; Chen, B; Howley, R; Kraus, D; Mansi, M; Myers, K; Palasuberniam, P1
Basoglu, H; Degirmencioglu, I; Eyupoglu, FC1
Ferreira, I; Fontana, LC; Mamone, LA; Pacheco-Soares, C; Pinto, JG; Strixino, JF; Vitorio, GDS1
Chen, B; Howley, R; Mansi, M1
Alfonso-García, A; Anbunesan, SN; Bec, J; Bloch, O; Fereidouni, F; Jin, LW; Lee, HS; Marcu, L; Zhou, X1
Chandratre, S; Chen, B; Howley, R; Mansi, M1
Harada, Y; Murayama, Y; Otsuji, E; Takamatsu, T; Tanaka, H1
Kämper, L; Lübbert, H; Novak, B; Schary, N; Yousf, A1
Kiening, M; Lange, N1
Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H1
Bruza, P; Pétusseau, A; Pogue, B1
Chen, Y; Deng, H; Feng, M; Guo, L; Yang, L1
Awazu, K; Fukuhara, H; Hazama, H; Inoue, K; Nishimura, T; Ogbonna, SJ; York, WY1
Bietar, K; Capobianco, JA; Mandl, GA; Maurizio, SL; Stochaj, U; Tessitore, G; Vettier, F1
Fukuda, Y; Grace, CR; Kavdia, K; Li, Y; Lynch, J; Peng, J; Ranjit, S; Robinson, CG; Schuetz, JD; Wang, Y; Xia, Y1
Kiesel, B; Lang, A; Millesi, M; Mischkulnig, M; Traxler, D; Wadiura, LI; Widhalm, G1

Reviews

56 review(s) available for protoporphyrin ix and aminolevulinic acid

ArticleYear
Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy.
    Journal of photochemistry and photobiology. B, Biology, 1992, Jul-30, Volume: 14, Issue:4

    Topics: Aminolevulinic Acid; Animals; Heme; Humans; Photochemotherapy; Prodrugs; Protoporphyrins

1992
Photodynamic therapy of primary skin cancer: a review.
    British journal of plastic surgery, 1995, Volume: 48, Issue:6

    Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents; Bowen's Disease; Carcinoma, Basal Cell; Female; Follow-Up Studies; Hematoporphyrin Derivative; Humans; Lasers; Photochemotherapy; Protoporphyrins; Skin Neoplasms

1995
[Porphyrin biosynthetic pathway and its regulation].
    Nihon rinsho. Japanese journal of clinical medicine, 1995, Volume: 53, Issue:6

    Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Erythrocytes; Heme; Liver; Porphyrins; Protoporphyrins

1995
[Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria].
    Nihon rinsho. Japanese journal of clinical medicine, 1995, Volume: 53, Issue:6

    Topics: Aminolevulinic Acid; Animals; Heme; Humans; Porphyrias; Porphyrins; Protoporphyrins

1995
Possible benefits of two-quantum excitation in ALA-PDT?
    Journal of photochemistry and photobiology. B, Biology, 1994, Volume: 23, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Humans; Light; Photochemotherapy; Porphyrins; Protoporphyrins; Quantum Theory; Tumor Cells, Cultured

1994
The regulation of enzymes involved in chlorophyll biosynthesis.
    European journal of biochemistry, 1996, Apr-15, Volume: 237, Issue:2

    Topics: Amino Acid Sequence; Aminolevulinic Acid; Chlorophyll; Chloroplasts; Gene Expression Regulation, Plant; Molecular Sequence Data; Molecular Structure; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Photosynthesis; Plants; Protochlorophyllide; Protoporphyrins; Pyrroles; Sequence Homology, Amino Acid; Tetrapyrroles

1996
5-Aminolevulinic acid-based photodynamic therapy: principles and experimental research.
    Photochemistry and photobiology, 1997, Volume: 65, Issue:2

    Topics: Aminolevulinic Acid; Animals; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

1997
5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges.
    Cancer, 1997, Jun-15, Volume: 79, Issue:12

    Topics: Aminolevulinic Acid; Forecasting; Heme; Humans; Neoplasms; Photochemotherapy; Protoporphyrins; Research; Skin Diseases; Skin Neoplasms

1997
Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): current clinical and development status.
    Journal of clinical laser medicine & surgery, 1996, Volume: 14, Issue:2

    Topics: Aminolevulinic Acid; Animals; Endometrium; Female; Gastrointestinal Neoplasms; Humans; Laser Therapy; Neoplasms; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Urinary Bladder Diseases

1996
Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): mechanisms and clinical results.
    Journal of clinical laser medicine & surgery, 1996, Volume: 14, Issue:5

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Humans; Photosensitizing Agents; Protoporphyrins

1996
Photodynamic therapy of Barrett's esophagus.
    Gastrointestinal endoscopy clinics of North America, 2000, Volume: 10, Issue:3

    Topics: Aminolevulinic Acid; Barrett Esophagus; Esophagoscopy; Fiber Optic Technology; Hematoporphyrin Derivative; Humans; Injections, Intravenous; Laser Therapy; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2000
Barrett's esophagus: treatment with 5-aminolevulinic acid photodynamic therapy.
    Gastrointestinal endoscopy clinics of North America, 2000, Volume: 10, Issue:3

    Topics: Aminolevulinic Acid; Barrett Esophagus; Esophagoscopy; Humans; Injections, Intravenous; Intestinal Mucosa; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment Outcome

2000
5-Aminolevulinic acid-induced protoporphyrin IX for the detection of gastrointestinal dysplasia.
    Gastrointestinal endoscopy clinics of North America, 2000, Volume: 10, Issue:3

    Topics: Aminolevulinic Acid; Animals; Endoscopy, Gastrointestinal; Gastrointestinal Neoplasms; Humans; Intestinal Mucosa; Photosensitizing Agents; Precancerous Conditions; Prognosis; Protoporphyrins; Spectrometry, Fluorescence

2000
Endoscopic fluorescence diagnosis and laser treatment of transitional cell carcinoma of the bladder.
    Seminars in urologic oncology, 2000, Volume: 18, Issue:4

    Topics: Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopy; Fluorescence; Humans; Laser Therapy; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms

2000
[Intraoperative photodynamic diagnosis of human glioma using ALA induced protoporphyrin IX].
    No shinkei geka. Neurological surgery, 2001, Volume: 29, Issue:11

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Male; Mice; Middle Aged; Monitoring, Intraoperative; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity

2001
On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation.
    Current medicinal chemistry. Anti-cancer agents, 2004, Volume: 4, Issue:3

    Topics: Aminolevulinic Acid; Animals; Hematoporphyrin Photoradiation; Heme; Humans; Molecular Structure; Neoplasms; Photosensitizing Agents; Protoporphyrins

2004
[Fluorescence imaging technique: diagnostic and therapeutic interest in gynecology].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2004, Volume: 33, Issue:8

    Topics: Aminolevulinic Acid; Breast Neoplasms; Female; Genital Diseases, Female; Gynecology; Humans; Neoplasms; Ovarian Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Uterine Cervical Neoplasms; Uterine Diseases; Vaginal Diseases; Vulvar Diseases

2004
[Intraoperative photodynamic diagnosis using 5-ALA for glioma surgery].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 9

    Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Monitoring, Intraoperative; Neoplasm, Residual; Neurosurgical Procedures; Photofluorography; Photosensitizing Agents; Protoporphyrins

2005
[Fluorescence diagnosis in dermatology].
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2003, Volume: 1, Issue:7

    Topics: Aminolevulinic Acid; Image Processing, Computer-Assisted; Optical Imaging; Protoporphyrins; Skin Diseases; Skin Neoplasms

2003
Use of ALA and ALA derivatives for optimizing ALA-based photodynamic therapy: a review of our experience.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Esterases; Heme; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins

2006
Repetitive photodynamic therapy of malignant brain tumors.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spheroids, Cellular

2006
Photodynamic therapies: principles and present medical applications.
    Bio-medical materials and engineering, 2006, Volume: 16, Issue:4 Suppl

    Topics: Aminolevulinic Acid; Bowen's Disease; Clinical Trials as Topic; Humans; Light; Lipoproteins, LDL; Male; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Diseases; Skin Neoplasms

2006
[Fluorescence diagnosis and photodynamic therapy with 5-aminolevulinic acid induced protoporphyrin IX in gynecology: an overview].
    Zentralblatt fur Gynakologie, 2006, Volume: 128, Issue:6

    Topics: Aminolevulinic Acid; Endometrial Neoplasms; Female; Genital Diseases, Female; Humans; Laparoscopy; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins

2006
["... The better to see you with"--phothodynamic diagnostic in superficial bladder cancer].
    Praxis, 2007, Oct-17, Volume: 96, Issue:42

    Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Carcinoma in Situ; Carcinoma, Papillary; Clinical Trials, Phase III as Topic; Cystoscopy; Disease Models, Animal; Fluorescence; Follow-Up Studies; Humans; Neoplasm Recurrence, Local; Photosensitizing Agents; Prospective Studies; Protoporphyrins; Randomized Controlled Trials as Topic; Rats; Reoperation; Sensitivity and Specificity; Time Factors; Urinary Bladder Neoplasms

2007
ALA and its clinical impact, from bench to bedside.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2008, Volume: 7, Issue:3

    Topics: Aminolevulinic Acid; Dendritic Cells; Fluorescence; Humans; Keratosis; Lymphocytes; Macrophages; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity

2008
Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy.
    Dermatology (Basel, Switzerland), 2009, Volume: 218, Issue:3

    Topics: Aminolevulinic Acid; Animals; Humans; Keratosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2009
New aspects in photodynamic therapy of actinic keratoses.
    Journal of photochemistry and photobiology. B, Biology, 2009, Sep-04, Volume: 96, Issue:3

    Topics: Aminolevulinic Acid; Humans; Keratosis, Actinic; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2009
[Intraoperative photo-dynamic diagnosis of brain tumors].
    Brain and nerve = Shinkei kenkyu no shinpo, 2009, Volume: 61, Issue:7

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperative Period; Meningeal Neoplasms; Meningioma; Microsurgery; Neurosurgical Procedures; Protoporphyrins; Surgery, Computer-Assisted; Ultraviolet Rays

2009
[Fluorescence diagnosis of non-melanoma skin cancer].
    Orvosi hetilap, 2012, Aug-26, Volume: 153, Issue:34

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Squamous Cell; Cell Proliferation; Cold Temperature; Fluorescence; Humans; Mohs Surgery; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Skin Neoplasms; Treatment Outcome

2012
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:11

    Topics: Aminolevulinic Acid; Brain Neoplasms; Disease-Free Survival; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Neurosurgical Procedures; Photosensitizing Agents; Positron-Emission Tomography; Protoporphyrins; Randomized Controlled Trials as Topic; Surgery, Computer-Assisted

2012
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:12

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted

2012
[Surgery of high-grade gliomas guided by fluorescence: a retrospective study of 22 patients].
    Neuro-Chirurgie, 2013, Volume: 59, Issue:1

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Microscopy, Fluorescence; Microsurgery; Middle Aged; Neoplasm Grading; Neoplasm, Residual; Neovascularization, Pathologic; Neuronavigation; Neurosurgical Procedures; Prognosis; Protoporphyrins; Retrospective Studies; Surgery, Computer-Assisted

2013
Innovations in the endoscopic management of bladder cancer: is the era of white light cystoscopy over.
    Urologia, 2013, Volume: 80 Spec No 1

    Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Transitional Cell; Cystoscopy; False Negative Reactions; Female; Forecasting; Humans; Light; Male; Multimodal Imaging; Neoplasm Recurrence, Local; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Tomography, Optical Coherence; Tomography, X-Ray Computed; Urinary Bladder Neoplasms

2013
5-Aminolevulinic acid-based fluorescence diagnostics of cervical preinvasive changes.
    Medicina (Kaunas, Lithuania), 2014, Volume: 50, Issue:3

    Topics: Aminolevulinic Acid; Female; Fluorescence; Humans; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms

2014
Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain tumor.
    Advances in cancer research, 2015, Volume: 125

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Brain Neoplasms; Gefitinib; Humans; Mice; Neoplasm Proteins; NF-E2-Related Factor 2; Oxidative Stress; Photochemotherapy; Porphyrins; Protein Kinase Inhibitors; Protoporphyrins; Quinazolines; Transcription, Genetic; Treatment Outcome

2015
Fluorescence guided resection and glioblastoma in 2015: A review.
    Lasers in surgery and medicine, 2015, Volume: 47, Issue:5

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted

2015
5-Aminolevulinic Acid-Protoporphyrin IX Fluorescence-Guided Surgery of High-Grade Gliomas: A Systematic Review.
    Advances and technical standards in neurosurgery, 2016, Issue:43

    Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Microscopy, Fluorescence; Microsurgery; Neoplasm Grading; Neoplasm, Residual; Neuronavigation; Protoporphyrins; Sensitivity and Specificity; Statistics as Topic; Surgery, Computer-Assisted

2016
Aminolevulinic Acid-Based Tumor Detection and Therapy: Molecular Mechanisms and Strategies for Enhancement.
    International journal of molecular sciences, 2015, Oct-28, Volume: 16, Issue:10

    Topics: Aminolevulinic Acid; Animals; Heme; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2015
5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction.
    International immunopharmacology, 2016, Volume: 37

    Topics: Aminolevulinic Acid; Heme; Heme Oxygenase-1; Histocompatibility; Humans; Immunity; Immunologic Factors; Inflammation; Macrophages; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction; Transplantation, Homologous

2016
Recent advances in photodynamic diagnosis of gastric cancer using 5-aminolevulinic acid.
    World journal of gastroenterology, 2016, Jan-21, Volume: 22, Issue:3

    Topics: Aminolevulinic Acid; Animals; Biomarkers, Tumor; Humans; Intraoperative Care; Luminescent Measurements; Lymphatic Metastasis; Molecular Diagnostic Techniques; Peritoneal Neoplasms; Predictive Value of Tests; Protoporphyrins; Reproducibility of Results; Stomach Neoplasms

2016
Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
    Acta neurochirurgica, 2016, Volume: 158, Issue:10

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Neurons; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins

2016
Multiple Means by Which Nitric Oxide can Antagonize Photodynamic Therapy.
    Current medicinal chemistry, 2016, Volume: 23, Issue:24

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Humans; Light; Neoplasms; Nitric Oxide; Nitric Oxide Synthase Type II; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2016
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.
    Microbiology and molecular biology reviews : MMBR, 2017, Volume: 81, Issue:1

    Topics: Aminolevulinic Acid; Archaea; Bacteria; Coproporphyrinogen Oxidase; Coproporphyrins; Heme; Iron; Protoporphyrins; Tetrapyrroles; Uroporphyrinogen Decarboxylase

2017
5-Aminolevulinic acid-mediated photodynamic therapy for bladder cancer.
    International journal of urology : official journal of the Japanese Urological Association, 2017, Volume: 24, Issue:2

    Topics: Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment Outcome; Urinary Bladder; Urinary Bladder Neoplasms

2017
Photodynamic therapy in dermatology beyond non-melanoma cancer: An update.
    Photodiagnosis and photodynamic therapy, 2017, Volume: 19

    Topics: Acne Vulgaris; Aminolevulinic Acid; Collagen; Humans; Photochemotherapy; Photosensitizing Agents; Port-Wine Stain; Procollagen; Protoporphyrins; Psoriasis; Reactive Oxygen Species; Rejuvenation; Scleroderma, Localized; Skin; Skin Diseases; Skin Temperature; Warts

2017
Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: A review.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 24

    Topics: Aminolevulinic Acid; Endometrial Neoplasms; Female; Genital Diseases, Female; Humans; Neoplasm Staging; Ovarian Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Remission Induction; Uterine Cervical Diseases

2018
The role of 5-aminolevulinic acid in spinal tumor surgery: a review.
    Journal of neuro-oncology, 2019, Volume: 141, Issue:3

    Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Optical Imaging; Protoporphyrins; Spinal Cord Neoplasms; Spinal Neoplasms; Surgery, Computer-Assisted

2019
5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery.
    Journal of neuro-oncology, 2019, Volume: 141, Issue:3

    Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Meningeal Neoplasms; Meningioma; Optical Imaging; Protoporphyrins; Surgery, Computer-Assisted

2019
Photodynamic therapy for skin cancer: How to enhance drug penetration?
    Journal of photochemistry and photobiology. B, Biology, 2019, Volume: 197

    Topics: Aminolevulinic Acid; Drug Compounding; Humans; Liposomes; Micelles; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms

2019
In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?
    British journal of cancer, 2019, Volume: 121, Issue:8

    Topics: Amino Acid Transport Systems; Aminolevulinic Acid; Brain Neoplasms; Coproporphyrinogens; Ferrochelatase; Fluorescence; Glucose; Heme; Humans; Iron; MicroRNAs; Mitochondria; Mutation; NADP; Neoplasms; Oncogenes; Optical Imaging; Peptide Transporter 1; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Symporters; Tumor Hypoxia; Tumor Microenvironment; Urinary Bladder Neoplasms

2019
Sonodynamic Therapy for Gliomas. Perspectives and Prospects of Selective Sonosensitization of Glioma Cells.
    Cells, 2019, 11-13, Volume: 8, Issue:11

    Topics: Aminolevulinic Acid; Animals; Diagnostic Imaging; Disease Models, Animal; Glioma; Humans; Light; Protoporphyrins; Ultrasonic Therapy; Ultrasonic Waves

2019
5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy.
    Journal of UOEH, 2020, Volume: 42, Issue:1

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Mitochondria; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Surgery, Computer-Assisted

2020
Key transporters leading to specific protoporphyrin IX accumulation in cancer cell following administration of aminolevulinic acid in photodynamic therapy/diagnosis.
    International journal of clinical oncology, 2021, Volume: 26, Issue:1

    Topics: Aminolevulinic Acid; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2021
SARS-CoV-2, hemoglobin and protoporphyrin IX: Interactions and perspectives.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 34

    Topics: Aminolevulinic Acid; COVID-19 Drug Treatment; Hemoglobins; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; SARS-CoV-2

2021
5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges.
    International journal of molecular sciences, 2022, Jun-09, Volume: 23, Issue:12

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Glioma; Heme; Humans; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiopharmaceuticals

2022
A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells.
    International journal of molecular sciences, 2022, Jul-19, Volume: 23, Issue:14

    Topics: Aminolevulinic Acid; Animals; Heme; Iron; Mammals; Neoplasms; Porphyrins; Protoporphyrins

2022

Trials

61 trial(s) available for protoporphyrin ix and aminolevulinic acid

ArticleYear
Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience.
    Journal of photochemistry and photobiology. B, Biology, 1990, Volume: 6, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Keratosis; Photochemotherapy; Prodrugs; Protoporphyrins; Radiation-Sensitizing Agents; Skin Neoplasms

1990
Sensitization and photodynamic therapy (PDT) of gastrointestinal tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX). A pilot study.
    Neoplasma, 1995, Volume: 42, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biotransformation; Female; Gastrointestinal Neoplasms; Humans; Male; Microscopy, Fluorescence; Middle Aged; Photochemotherapy; Pilot Projects; Protoporphyrins; Tissue Distribution

1995
Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid.
    Urology, 1994, Volume: 44, Issue:6

    Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cystoscopy; Female; Fluorescence; Humans; Male; Middle Aged; Predictive Value of Tests; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder; Urinary Bladder Neoplasms

1994
Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic treatment.
    Archives of dermatological research, 1995, Volume: 287, Issue:7

    Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Humans; Male; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins; Skin Neoplasms

1995
Side effects and photosensitization of human tissues after aminolevulinic acid.
    The Journal of surgical research, 1997, Feb-15, Volume: 68, Issue:1

    Topics: Adenocarcinoma; Administration, Oral; Aminolevulinic Acid; Female; Gastrointestinal Neoplasms; Humans; Liver; Liver Function Tests; Male; Nausea; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tissue Distribution; Vomiting

1997
The variable response of plaque psoriasis after a single treatment with topical 5-aminolaevulinic acid photodynamic therapy.
    The British journal of dermatology, 1997, Volume: 137, Issue:5

    Topics: Aminolevulinic Acid; Chronic Disease; Dose-Response Relationship, Radiation; Humans; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Psoriasis; Treatment Outcome

1997
Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid.
    Photochemistry and photobiology, 1998, Volume: 67, Issue:2

    Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Basal Cell; Drug Interactions; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms

1998
Photodynamic therapy for gastrointestinal tumors using three photosensitizers--ALA induced PPIX, Photofrin and MTHPC. A pilot study.
    Neoplasma, 1998, Volume: 45, Issue:3

    Topics: Adult; Aged; Aminolevulinic Acid; Dihematoporphyrin Ether; Duodenal Neoplasms; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Lasers; Male; Mesoporphyrins; Middle Aged; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Prodrugs; Protoporphyrins; Rectal Neoplasms

1998
Treatment of oral leukoplakia by topical application of 5-aminolevulinic acid.
    International journal of oral and maxillofacial surgery, 1998, Volume: 27, Issue:6

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Argon; Female; Humans; Laser Therapy; Leukoplakia, Oral; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment Outcome

1998
In vivo detection of basal cell carcinoma using imaging spectroscopy.
    Acta dermato-venereologica, 1999, Volume: 79, Issue:1

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Basal Cell; Dermatologic Surgical Procedures; Female; Humans; Male; Microscopy, Fluorescence; Middle Aged; Mohs Surgery; Protoporphyrins; Skin; Skin Neoplasms

1999
Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study.
    British journal of cancer, 1999, Volume: 80, Issue:1-2

    Topics: Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Spectrometry, Fluorescence; Urinary Bladder Neoplasms

1999
Kinetic fluorescence studies of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation in basal cell carcinomas.
    Journal of photochemistry and photobiology. B, Biology, 1999, Volume: 49, Issue:2-3

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Humans; Kinetics; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence

1999
Photodynamic cystoscopy for detection of bladder tumors.
    Seminars in laparoscopic surgery, 1999, Volume: 6, Issue:2

    Topics: Adenocarcinoma, Papillary; Administration, Intravesical; Aminolevulinic Acid; Biopsy; Cystoscopy; Diagnosis, Differential; Fiber Optic Technology; Fluorescence; Follow-Up Studies; Humans; Neoplasm Recurrence, Local; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity; Urinary Bladder Neoplasms; Urothelium

1999
5-Aminolevulinic acid photosensitization of dysplastic Barrett's esophagus: a pharmacokinetic study.
    Photochemistry and photobiology, 1999, Volume: 70, Issue:4

    Topics: Aminolevulinic Acid; Barrett Esophagus; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

1999
Preliminary evaluation of two fluorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin.
    Lasers in surgery and medicine, 2000, Volume: 26, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Male; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence

2000
A vehicle for photodynamic therapy of skin cancer: influence of dimethylsulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy.
    Journal of controlled release : official journal of the Controlled Release Society, 2000, Apr-03, Volume: 65, Issue:3

    Topics: Aminolevulinic Acid; Animals; Dimethyl Sulfoxide; Humans; Mice; Mice, Hairless; Microscopy, Confocal; Myristates; Pharmaceutical Vehicles; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Absorption; Skin Neoplasms; Solubility

2000
Heterogeneity of delta-aminolevulinic acid-induced protoporphyrin IX fluorescence in human glioma cells and leukemic lymphocytes.
    Neurological research, 2000, Volume: 22, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Female; Glioblastoma; Humans; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocytes; Male; Microscopy, Confocal; Microscopy, Fluorescence; Middle Aged; Photochemistry; Phototherapy; Protoporphyrins; Tumor Cells, Cultured

2000
Diagnostic efficacy of fluorescence cystoscopy for detection of urothelial neoplasms.
    Journal of endourology, 2001, Volume: 15, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma in Situ; Cystoscopy; Female; Fluorescence; Humans; Light; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder Neoplasms

2001
Detection of female lower genital tract dysplasia using orally administered 5-aminolevulinic acid induced protoporphyrin IX: a preliminary study.
    Gynecologic oncology, 2002, Volume: 85, Issue:1

    Topics: Administration, Oral; Aminolevulinic Acid; Female; Humans; Papanicolaou Test; Photochemotherapy; Protoporphyrins; Uterine Cervical Dysplasia; Vaginal Smears

2002
Clinical pharmacokinetics of 5-aminolevulinic acid in healthy volunteers and patients at high risk for recurrent bladder cancer.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2

    Topics: Administration, Intravesical; Administration, Oral; Aminolevulinic Acid; Cross-Over Studies; Drug Administration Routes; Humans; Injections, Intravenous; Photosensitizing Agents; Protoporphyrins; Recurrence; Risk Factors; Urinary Bladder Neoplasms

2002
Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques.
    The Journal of investigative dermatology, 2002, Volume: 119, Issue:1

    Topics: Administration, Oral; Aminolevulinic Acid; Apoptosis; CD3 Complex; Epidermis; Erythema; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; T-Lymphocytes; Treatment Outcome

2002
Timing of 5-aminolaevulinic acid-induced photodynamic therapy for the treatment of patients with Barrett's oesophagus.
    Journal of photochemistry and photobiology. B, Biology, 2002, Volume: 68, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Biopsy; Endoscopy; Female; Gastric Mucosa; Humans; Male; Metabolic Clearance Rate; Middle Aged; Mucous Membrane; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reference Values; Tissue Distribution

2002
A randomised, double-blind, placebo-controlled trial of photodynamic therapy using 5-aminolaevulinic acid for the treatment of cervical intraepithelial neoplasia.
    International journal of cancer, 2003, Mar-01, Volume: 103, Issue:6

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Cervix Uteri; Colposcopy; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms

2003
Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer.
    The Journal of urology, 2003, Volume: 170, Issue:2 Pt 1

    Topics: Administration, Intravesical; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Female; Humans; Male; Microscopy, Fluorescence; Middle Aged; Neoplasm Recurrence, Local; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Urinary Bladder; Urinary Bladder Neoplasms

2003
The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical 5-aminolaevulinic acid photodynamic therapy.
    The British journal of dermatology, 2003, Volume: 149, Issue:1

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Deferoxamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Erythema; Female; Fluorescence; Humans; Iontophoresis; Iron Chelating Agents; Male; Middle Aged; Photochemotherapy; Protoporphyrins; Skin Neoplasms

2003
Fluorescence-guided resections of malignant gliomas--an overview.
    Acta neurochirurgica. Supplement, 2003, Volume: 88

    Topics: Aminolevulinic Acid; Biopsy; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Division; Fluorescence; Germany; Glioma; Humans; Ki-67 Antigen; Microsurgery; Neoplasm, Residual; Neovascularization, Pathologic; Postoperative Complications; Prognosis; Protoporphyrins; Sensitivity and Specificity; Survival Rate

2003
Comparison of high- vs low-dose 5-aminolevulinic acid for photodynamic therapy of Barrett's esophagus.
    Surgical endoscopy, 2004, Volume: 18, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Lasers; Male; Middle Aged; Photochemotherapy; Protoporphyrins; Treatment Outcome

2004
Laparoscopic fluorescence detection of ovarian carcinoma metastases using 5-aminolevulinic acid-induced protoporphyrin IX.
    Cancer, 2004, Apr-15, Volume: 100, Issue:8

    Topics: Adult; Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Infusions, Parenteral; Laparoscopy; Middle Aged; Ovarian Neoplasms; Peritoneal Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity

2004
Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy.
    Journal of photochemistry and photobiology. B, Biology, 2006, Apr-03, Volume: 83, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Humans; Middle Aged; Mouth Neoplasms; Patient Selection; Precancerous Conditions; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence

2006
Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Fluorescence; Humans; Lasers; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms

2006
A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis.
    The British journal of dermatology, 2006, Volume: 155, Issue:2

    Topics: Adult; Aminolevulinic Acid; Cell Differentiation; Cell Proliferation; Dose Fractionation, Radiation; Drug Administration Schedule; Epidermis; Female; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Severity of Illness Index; Skin; T-Lymphocyte Subsets; Treatment Outcome

2006
Topical 5-aminolevulinic acid mediated photodynamic therapy of superficial basal cell carcinoma using two light fractions with a two-hour interval: long-term follow-up.
    Acta dermato-venereologica, 2006, Volume: 86, Issue:5

    Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Pilot Projects; Protoporphyrins; Skin Neoplasms

2006
In-vivo kinetics of inhaled 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in bronchial tissue.
    Respiratory research, 2007, Apr-19, Volume: 8

    Topics: Administration, Inhalation; Aged; Aged, 80 and over; Aminolevulinic Acid; Bronchi; Bronchial Neoplasms; Bronchoscopy; Female; Humans; Image Enhancement; Kinetics; Male; Metabolic Clearance Rate; Microscopy, Fluorescence; Middle Aged; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity

2007
ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2007, Volume: 26, Issue:2

    Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Fluorescence; Glioma; Humans; Neurosurgical Procedures; Photochemotherapy; Photosensitizing Agents; Prospective Studies; Protoporphyrins

2007
Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma.
    Journal of cancer research and clinical oncology, 2008, Volume: 134, Issue:8

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Cell Line, Tumor; Humans; In Vitro Techniques; Iron Chelating Agents; Middle Aged; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Pyridones; Skin Neoplasms

2008
Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial.
    Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:3

    Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Edema; Erythema; Female; Fluorescence; Humans; Laser Therapy; Male; Pain; Patient Satisfaction; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Diseases; Treatment Outcome

2008
Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded study.
    The British journal of dermatology, 2008, Volume: 158, Issue:4

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Dose-Response Relationship, Drug; Facial Dermatoses; Female; Heliotherapy; Humans; Keratosis; Male; Middle Aged; Pain Measurement; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp Dermatoses; Single-Blind Method; Treatment Outcome

2008
Surgical outcomes of fluorescence-guided laparoscopic partial nephrectomy using 5-aminolevulinic acid-induced protoporphyrin IX.
    The Journal of surgical research, 2009, Jun-15, Volume: 154, Issue:2

    Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Renal Cell; Female; Fluorescence; Humans; Kidney Neoplasms; Laparoscopy; Male; Middle Aged; Monitoring, Intraoperative; Nephrectomy; Photosensitizing Agents; Predictive Value of Tests; Prospective Studies; Protoporphyrins

2009
A time course investigation of the fluorescence induced by topical application of 5-aminolevulinic acid and methyl aminolevulinate on normal human skin.
    Photodermatology, photoimmunology & photomedicine, 2009, Volume: 25, Issue:4

    Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Time Factors

2009
Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema.
    Pharmaceutical research, 2010, Volume: 27, Issue:10

    Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Erythema; Female; Humans; Light; Male; Needles; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Punctures; Silicon; Skin; Skin Absorption

2010
Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2010, Volume: 7, Issue:4

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Photobleaching; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Skin Neoplasms

2010
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
    Journal of neurosurgery, 2011, Volume: 115, Issue:1

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Male; Meningioma; Middle Aged; Photosensitizing Agents; Protoporphyrins; Young Adult

2011
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
    The British journal of dermatology, 2011, Volume: 164, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Scalp Dermatoses; Skin Neoplasms

2011
PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alone in fluorescence detection of non-melanoma skin cancer: an intra-patient direct comparison study.
    Lasers in surgery and medicine, 2012, Volume: 44, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Bowen's Disease; Carcinoma; Carcinoma, Basal Cell; False Negative Reactions; False Positive Reactions; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Single-Blind Method; Skin Neoplasms; Spectrometry, Fluorescence

2012
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies.
    Acta neurochirurgica, 2012, Volume: 154, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy, Needle; Brain Neoplasms; Female; Glioblastoma; Humans; Male; Microscopy, Fluorescence; Middle Aged; Monitoring, Intraoperative; Neuronavigation; Protoporphyrins

2012
Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy.
    Lasers in medical science, 2013, Volume: 28, Issue:3

    Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Oxygen; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Pressure; Protoporphyrins; Skin Neoplasms

2013
The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device.
    Journal of photochemistry and photobiology. B, Biology, 2012, Dec-05, Volume: 117

    Topics: Aminolevulinic Acid; Biological Transport; Carcinoma, Basal Cell; Injections; Oxygen; Photosensitizing Agents; Pressure; Prodrugs; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Time Factors

2012
Protoporphyrin IX fluorescence and photobleaching during interstitial photodynamic therapy of malignant gliomas for early treatment prognosis.
    Lasers in surgery and medicine, 2013, Volume: 45, Issue:4

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Biopsy; Brain; Brain Neoplasms; Female; Fluorescence; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Photobleaching; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Prospective Studies; Protoporphyrins; Spectrometry, Fluorescence; Treatment Outcome

2013
Light protection of the skin after photodynamic therapy reduces inflammation: an unblinded randomized controlled study.
    The British journal of dermatology, 2014, Volume: 171, Issue:1

    Topics: Aminolevulinic Acid; Drug Eruptions; Erythema; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Middle Aged; Photochemotherapy; Photosensitivity Disorders; Photosensitizing Agents; Protoporphyrins; Sunlight; Sunscreening Agents; Treatment Outcome

2014
Biodistribution of protoporphyrin IX in female genital erosive lichen planus after topical application of hexaminolevulinate.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Dose-Response Relationship, Drug; Female; Genital Diseases, Female; Humans; Lichen Planus; Metabolic Clearance Rate; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tissue Distribution; Treatment Outcome

2014
Topical corticosteroid reduces inflammation without compromising the efficacy of photodynamic therapy for actinic keratoses: a randomized clinical trial.
    The British journal of dermatology, 2014, Volume: 171, Issue:6

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Anti-Inflammatory Agents; Clobetasol; Erythema; Facial Dermatoses; Female; Fluoroscopy; Glucocorticoids; Humans; Keratosis, Actinic; Male; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp Dermatoses; Treatment Outcome

2014
Protoporphyrin IX formation after topical application of methyl aminolaevulinate and BF-200 aminolaevulinic acid declines with age.
    The British journal of dermatology, 2015, Volume: 173, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Age Factors; Aminolevulinic Acid; Drug Combinations; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Young Adult

2015
Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Optical Imaging; Photosensitizing Agents; Point-of-Care Systems; Protoporphyrins; Skin Neoplasms

2015
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:4

    Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratosis, Actinic; Male; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

2015
Artificial White Light vs Daylight Photodynamic Therapy for Actinic Keratoses: A Randomized Clinical Trial.
    JAMA dermatology, 2016, 06-01, Volume: 152, Issue:6

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Facial Dermatoses; Follow-Up Studies; Humans; Keratosis, Actinic; Light; Male; Middle Aged; Patient Satisfaction; Photochemotherapy; Photosensitizing Agents; Prospective Studies; Protoporphyrins; Scalp Dermatoses; Single-Blind Method; Time Factors; Treatment Outcome

2016
Pulse photodynamic therapy reduces inflammation without compromising efficacy in the treatment of multiple mild actinic keratoses of the face and scalp: a randomized clinical trial.
    The British journal of dermatology, 2016, Volume: 174, Issue:5

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Erythema; Facial Dermatoses; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Ointments; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp Dermatoses; Treatment Outcome

2016
Increased protoporphyrin IX accumulation does not improve the effect of photodynamic therapy for actinic keratosis: a randomized controlled trial.
    The British journal of dermatology, 2017, Volume: 176, Issue:5

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Curettage; Drug Eruptions; Erythema; Female; Fluorescence; Hand Dermatoses; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; Pain Measurement; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2017
Comparison of Physical Pretreatment Regimens to Enhance Protoporphyrin IX Uptake in Photodynamic Therapy: A Randomized Clinical Trial.
    JAMA dermatology, 2017, Apr-01, Volume: 153, Issue:4

    Topics: Adolescent; Adult; Aminolevulinic Acid; Curettage; Denmark; Dermabrasion; Female; Fluorescence; Humans; Laser Therapy; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Young Adult

2017
A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma.
    Neurosurgery, 2017, Jul-01, Volume: 81, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Craniotomy; Dose-Response Relationship, Drug; Europe; Female; Fluorescence; Glioma; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins

2017
Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 22

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Curettage; Face; Female; Humans; Keratosis, Actinic; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Scalp

2018
Enhancement of Photodynamic Therapy for Bowen's Disease Using Plum-Blossom Needling to Augment Drug Delivery.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2018, Volume: 44, Issue:12

    Topics: Aged; Aminolevulinic Acid; Bowen's Disease; Drug Delivery Systems; Female; Fluorescence; Humans; Male; Middle Aged; Needles; Photochemotherapy; Photosensitizing Agents; Prospective Studies; Protoporphyrins; Skin Neoplasms

2018

Other Studies

743 other study(ies) available for protoporphyrin ix and aminolevulinic acid

ArticleYear
Comparing the efficacy of photodynamic and sonodynamic therapy in non-melanoma and melanoma skin cancer.
    Bioorganic & medicinal chemistry, 2016, 07-01, Volume: 24, Issue:13

    Topics: Aminolevulinic Acid; Animals; Heterografts; Humans; Melanoma; Mice, SCID; Photochemotherapy; Skin Neoplasms; Ultrasonic Therapy

2016
Photodestruction of tumor cells by induction of endogenous accumulation of protoporphyrin IX: enhancement by 1,10-phenanthroline.
    Photochemistry and photobiology, 1992, Volume: 55, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Division; Humans; Phenanthrolines; Photochemotherapy; Protoporphyrins; Tumor Cells, Cultured

1992
Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model.
    British journal of cancer, 1992, Volume: 65, Issue:6

    Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Intestinal Mucosa; Microscopy, Fluorescence; Neoplasms, Experimental; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Time Factors

1992
Enzymatic basis of thiol-stimulated secretion of porphyrins by Escherichia coli.
    Journal of bacteriology, 1992, Volume: 174, Issue:3

    Topics: Aminolevulinic Acid; Coproporphyrins; Escherichia coli; Glycerol; Hemin; Porphyrins; Protoporphyrins; RNA, Transfer, Amino Acyl; RNA, Transfer, Glu

1992
Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man.
    The Journal of biological chemistry, 1991, Nov-15, Volume: 266, Issue:32

    Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Blotting, Northern; Feedback; Hematologic Diseases; Heme; Humans; Kinetics; Protein Synthesis Inhibitors; Protoporphyrins; Reticulocytes; RNA, Messenger

1991
Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence.
    The American journal of pathology, 1990, Volume: 136, Issue:4

    Topics: Aminolevulinic Acid; Animals; Ear; Fluorescence; Hair; Levulinic Acids; Mice; Photochemotherapy; Porphyrins; Protoporphyrins; Sebaceous Glands

1990
Pharmacological activities of delta-aminolaevulinic acid, protoporphyrin IX and haemin in isolated preparations of rabbit gastric fundus and jejunum.
    Journal of autonomic pharmacology, 1990, Volume: 10, Issue:2

    Topics: Aminolevulinic Acid; Animals; Female; Gastric Fundus; Heme; Hemin; In Vitro Techniques; Jejunum; Levulinic Acids; Male; Muscle Contraction; Muscle, Smooth; Porphyrins; Prazosin; Protoporphyrins; Rabbits

1990
Pharmacological effects of haem biosynthetic intermediates in isolated intestinal preparations.
    European journal of pharmacology, 1987, Feb-24, Volume: 134, Issue:3

    Topics: Aminolevulinic Acid; Animals; Colon; Coproporphyrins; Female; Glycine; Heme; Hemin; In Vitro Techniques; Intestinal Mucosa; Intestines; Jejunum; Male; Muscle Contraction; Porphobilinogen; Protoporphyrins; Rabbits; Succinates

1987
Protoporphyrin accumulation by mitogen stimulated lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria variegata and erythropoietic protoporphyria: evidence for deficiency of protoporphyrinogen oxidase and ferrochelatase in both
    British journal of haematology, 1985, Volume: 60, Issue:1

    Topics: Adult; Aminolevulinic Acid; Child; Edetic Acid; Ferrochelatase; Flavoproteins; Humans; Iron; Liver Diseases; Lymphocytes; Mitochondrial Proteins; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Porphyrias; Porphyrins; Protoporphyrinogen Oxidase; Protoporphyrins; Skin Diseases

1985
Synthesis of [14C]coproporphyrin III by yeast cell-free extracts.
    Analytical biochemistry, 1982, Volume: 126, Issue:1

    Topics: Aminolevulinic Acid; Cell-Free System; Chromatography; Coproporphyrins; Methods; Porphyrins; Protoporphyrins; Saccharomyces cerevisiae

1982
Blood protoporphyrin IX as a biological indicator of increased absorption of lead.
    Toxicology letters, 1981, Volume: 7, Issue:3

    Topics: Adult; Aminolevulinic Acid; Humans; Lead; Lead Poisoning; Male; Mexico; Occupational Diseases; Porphyrins; Protoporphyrins

1981
Mechanism of thiamine-induced respiratory deficiency in Saccharomyces carlsbergensis.
    Journal of bacteriology, 1981, Volume: 147, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrins; Cytochromes; Heme; Protoporphyrins; Pyridoxine; Saccharomyces; Thiamine

1981
Mitogenic and co-mitogenic properties of hemin.
    Journal of immunology (Baltimore, Md. : 1950), 1981, Volume: 127, Issue:6

    Topics: Adult; Aminolevulinic Acid; Animals; Biliverdine; Cattle; Concanavalin A; Heme; Hemin; Horses; Humans; Immunity, Cellular; Lymphocyte Activation; Middle Aged; Mitogens; Protoporphyrins; Thymidine

1981
Efficacy of intravenous delta-aminolaevulinic acid photodynamic therapy on rabbit papillomas.
    British journal of cancer, 1995, Volume: 72, Issue:4

    Topics: Aminolevulinic Acid; Animals; Papilloma; Photochemotherapy; Protoporphyrins; Rabbits; Skin

1995
The effect of aminolaevulinic acid-induced, protoporphyrin IX-mediated photodynamic therapy on the cremaster muscle microcirculation in vivo.
    British journal of cancer, 1995, Volume: 72, Issue:5

    Topics: Aminolevulinic Acid; Animals; Arterioles; Male; Microcirculation; Muscle, Skeletal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Venules

1995
Wavelength dependency of photodynamic effects after sensitization with 5-aminolevulinic acid in vitro and in vivo.
    The Journal of investigative dermatology, 1995, Volume: 105, Issue:5

    Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Survival; Cricetinae; Humans; Keratinocytes; Light; Mesocricetus; Microscopy, Confocal; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

1995
Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice.
    Journal of photochemistry and photobiology. B, Biology, 1995, Volume: 28, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Colonic Neoplasms; Dimethyl Sulfoxide; Edetic Acid; Female; Kinetics; Mice; Mice, Inbred BALB C; Protoporphyrins; Skin; Spectrometry, Fluorescence; Time Factors

1995
Subcellular localization of and photosensitization by protoporphyrin IXhuman keratinocytes and fibroblasts cultivated with 5-aminolevulinic acid.
    Photochemistry and photobiology, 1995, Volume: 62, Issue:1

    Topics: Aminolevulinic Acid; Cells, Cultured; Fibrinogen; Fibroblasts; Humans; Keratinocytes; Photochemistry; Photosensitizing Agents; Porphyrins; Protoporphyrins; Spectrometry, Fluorescence; Subcellular Fractions

1995
Enhancement of photodynamic therapy with 5-aminolaevulinic acid-induced porphyrin photosensitisation in normal rat colon by threshold and light fractionation studies.
    British journal of cancer, 1995, Volume: 72, Issue:3

    Topics: Aminolevulinic Acid; Animals; Colon; Colonic Neoplasms; Female; Light; Maximum Allowable Concentration; Photochemotherapy; Protoporphyrins; Radiation-Sensitizing Agents; Rats; Rats, Wistar

1995
Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid.
    Lancet (London, England), 1993, Jul-17, Volume: 342, Issue:8864

    Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Squamous Cell; Fluorescence; Humans; Laser Therapy; Mouth Neoplasms; Necrosis; Palliative Care; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

1993
Treatment with 5-aminolevulinic acid and photoactivating light causes destruction of preimplantation mouse embryos.
    Fertility and sterility, 1995, Volume: 63, Issue:5

    Topics: Aminolevulinic Acid; Animals; Blastocyst; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Light; Mice; Morula; Photochemistry; Pregnancy; Protoporphyrins; Spectrometry, Fluorescence

1995
Combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX.
    Radiation research, 1995, Volume: 142, Issue:3

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Cycle; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Flow Cytometry; G2 Phase; Humans; Kinetics; Light; Protoporphyrins; Radiation-Sensitizing Agents; Radiation, Ionizing; S Phase; Time Factors; Tumor Cells, Cultured; X-Rays

1995
The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA).
    Photochemistry and photobiology, 1995, Volume: 61, Issue:5

    Topics: Aminolevulinic Acid; Cells, Cultured; Heme; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Photochemotherapy; Protoporphyrins; Receptors, Transferrin; Reference Values; Sezary Syndrome; Skin Neoplasms

1995
[Superficial bladder tumors. Pathological and clinical review and presentation of a new diagnostic method: fluorescence photodetection of transitional epithelial carcinomas based on protoporphyrin IX induction with delta-aminolevulinic acid (5-ALA)].
    Revue medicale de la Suisse romande, 1995, Volume: 115, Issue:3

    Topics: Aged; Aged, 80 and over; Algorithms; Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopy; Female; Humans; Male; Middle Aged; Protoporphyrins; Spectrometry, Fluorescence; Urinary Bladder Neoplasms

1995
Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands.
    British journal of cancer, 1995, Volume: 71, Issue:2

    Topics: Aminolevulinic Acid; Animals; Benzodiazepines; Benzodiazepinones; Cell Division; Cell Survival; Clonazepam; Flumazenil; Isoquinolines; Ligands; Mitochondria; Oxygen; Pancreatic Neoplasms; Photochemotherapy; Protoporphyrins; Radiation-Protective Agents; Radiation-Sensitizing Agents; Rats; Receptors, GABA-A; Singlet Oxygen; Tumor Cells, Cultured

1995
Biodistribution and phototoxicity of 5-aminolevulinic acid-induced PpIX in an orthotopic rat bladder tumor model.
    The Journal of urology, 1995, Volume: 153, Issue:3 Pt 1

    Topics: Aminolevulinic Acid; Animals; Female; Neoplasm Transplantation; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred F344; Tissue Distribution; Urinary Bladder Neoplasms

1995
Studies of porphyrin-containing specimens using an optical spectrometer connected to a confocal scanning laser microscope.
    Journal of microscopy, 1994, Volume: 176, Issue:Pt 3

    Topics: Aminolevulinic Acid; Animals; Hematoporphyrin Derivative; Liver; Microscopy, Confocal; Protoporphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence

1994
[Photodynamic diagnosis of urothelial neoplasms after intravesicular instillation of 5-aminolevulinic acid].
    Der Urologe. Ausg. A, 1994, Volume: 33, Issue:4

    Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Carcinoma, Transitional Cell; Cystoscopes; Female; Fluorescence; Humans; Image Processing, Computer-Assisted; Laser Therapy; Lasers; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Precancerous Conditions; Protoporphyrins; Urinary Bladder; Urinary Bladder Neoplasms; Video Recording

1994
In vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid-induced porphyrin: increased damage after multiple irradiations.
    British journal of cancer, 1994, Volume: 70, Issue:5

    Topics: Aminolevulinic Acid; Animals; Drug Administration Schedule; Female; Fluorescence; Kinetics; Mammary Neoplasms, Experimental; Necrosis; Neoplasm Transplantation; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred Strains; Time Factors

1994
Intravesical instillation of 5-aminolevulinic acid: the fluorescent metabolite is limited to urothelial cells.
    Urology, 1994, Volume: 44, Issue:5

    Topics: Administration, Intravesical; Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Papillary; Cell Line, Transformed; Cells, Cultured; Cystoscopy; Epithelium; Fibroblasts; Humans; Hyperplasia; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins; Urinary Bladder; Urinary Bladder Neoplasms

1994
Photodynamic destruction of endometrial tissue with topical 5-aminolevulinic acid in rats and rabbits.
    American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:5

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Endometrium; Female; Fluorescence; Microscopy, Electron, Scanning; Photochemotherapy; Protoporphyrins; Rabbits; Rats; Rats, Sprague-Dawley; Uterus

1994
Kinetics of endogenous protoporphyrin IX induction by aminolevulinic acid: preliminary studies in the bladder.
    The Journal of urology, 1994, Volume: 152, Issue:2 Pt 1

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Female; Injections, Intravenous; Kinetics; Photochemotherapy; Protoporphyrins; Rats; Rats, Wistar; Urinary Bladder

1994
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
    British journal of cancer, 1994, Volume: 70, Issue:1

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; Cells, Cultured; Deferoxamine; Ferrochelatase; Fibroblasts; Humans; Melanoma; Mice; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Protoporphyrins; Rats; Skin Neoplasms; Spectrometry, Fluorescence; Tumor Cells, Cultured; Up-Regulation; Urinary Bladder Neoplasms; Verapamil

1994
Photodynamic therapy of normal rat arteries after photosensitisation using disulphonated aluminium phthalocyanine and 5-aminolaevulinic acid.
    British journal of cancer, 1994, Volume: 70, Issue:1

    Topics: Aminolevulinic Acid; Animals; Arteries; Endothelium, Vascular; Female; Femoral Artery; Indoles; Muscle, Smooth, Vascular; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Regeneration; Spectrometry, Fluorescence; Vascular Patency

1994
Photodynamic therapy using 5-aminolaevulinic acid for experimental pancreatic cancer--prolonged animal survival.
    British journal of cancer, 1994, Volume: 70, Issue:2

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cricetinae; Disease Models, Animal; Female; Heme; Injections, Intravenous; Lasers; Mesocricetus; Microscopy, Fluorescence; Neoplasm Transplantation; Pancreatic Neoplasms; Photochemotherapy; Protoporphyrins; Sensitivity and Specificity; Time Factors

1994
Penetration potency of topical applied delta-aminolevulinic acid for photodynamic therapy of basal cell carcinoma.
    Photochemistry and photobiology, 1994, Volume: 59, Issue:1

    Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins; Skin Neoplasms

1994
In vivo photoproduct formation during PDT with ALA-induced endogenous porphyrins.
    Journal of photochemistry and photobiology. B, Biology, 1993, Volume: 18, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Female; Humans; Kinetics; Light; Mice; Mice, Nude; Neoplasm Transplantation; Photochemotherapy; Porphyrins; Protoporphyrins; Skin; Spectrometry, Fluorescence; Transplantation, Heterologous; Transplantation, Heterotopic; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1993
The production of porphyrins from delta-aminolaevulinic acid by Haemophilus parainfluenzae.
    Journal of medical microbiology, 1993, Volume: 39, Issue:4

    Topics: Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture Media; Haemophilus; Hydrogen-Ion Concentration; Porphyrins; Protoporphyrins

1993
delta-Aminolevulinic acid induced fluorescence in tumour-bearing mice.
    Journal of photochemistry and photobiology. B, Biology, 1995, Volume: 30, Issue:1

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Lewis Lung; Female; Fibrosarcoma; Fluorescence; Hematoporphyrins; Leukemia, Lymphoid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms, Experimental; Photosensitizing Agents; Protoporphyrins; Time Factors

1995
HepG2 human hepatocarcinoma cells: an experimental model for photosensitization by endogenous porphyrins.
    Journal of photochemistry and photobiology. B, Biology, 1995, Volume: 30, Issue:2-3

    Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Flow Cytometry; Hematoporphyrins; Humans; Lasers; Models, Biological; Photosensitizing Agents; Phototherapy; Protoporphyrins; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured

1995
Cellular fluorescence of the endogenous photosensitizer protoporphyrin IX following exposure to 5-aminolevulinic acid.
    Photochemistry and photobiology, 1995, Volume: 62, Issue:5

    Topics: Aminolevulinic Acid; Cell Line; Flow Cytometry; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Urinary Bladder; Urinary Bladder Neoplasms

1995
Subcellular damage kinetics within co-cultivated WI38 and VA13-transformed WI38 human fibroblasts following 5-aminolevulinic acid-induced protoporphyrin IX formation.
    Photochemistry and photobiology, 1995, Volume: 62, Issue:6

    Topics: Aminolevulinic Acid; Cell Line, Transformed; Fibroblasts; Humans; Lung; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Subcellular Fractions

1995
Fluorescence and photosensitization of experimental endometriosis in the rat after systemic 5-aminolevulinic acid administration: a potential new approach to the diagnosis and treatment of endometriosis.
    American journal of obstetrics and gynecology, 1996, Volume: 174, Issue:1 Pt 1

    Topics: Aminolevulinic Acid; Animals; Endometriosis; Female; Fluorescence; Kinetics; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence

1996
Flow cytometric technique for quantitating cytotoxic response to photodynamic therapy.
    Photochemistry and photobiology, 1996, Volume: 63, Issue:1

    Topics: Aminolevulinic Acid; Carcinoma, Small Cell; Cell Survival; Flow Cytometry; Humans; Lung Neoplasms; Photochemotherapy; Protoporphyrins; Tumor Cells, Cultured

1996
Fluorescence cystoscopy following intravesical instillation of 5-aminolevulinic acid: a new procedure with high sensitivity for detection of hardly visible urothelial neoplasias.
    Urologia internationalis, 1995, Volume: 55, Issue:4

    Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cystoscopy; Epithelium; Fluorescence; Humans; Microscopy, Fluorescence; Middle Aged; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Urinary Bladder Neoplasms

1995
Photosensitization of the endometrium with topical 5-aminolevulinic acid.
    American journal of obstetrics and gynecology, 1995, Volume: 173, Issue:6

    Topics: Administration, Topical; Aminolevulinic Acid; Biotransformation; Endometrium; Female; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

1995
Kinetics and localisation of PpIX fluorescence after topical and systemic ALA application, observed in skin and skin tumours of UVB-treated mice.
    British journal of cancer, 1996, Volume: 73, Issue:7

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Female; Injections, Intraperitoneal; Keratitis; Mice; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Ultraviolet Rays

1996
A comparative study of tissue distribution and photodynamic therapy selectivity of chlorin e6, Photofrin II and ALA-induced protoporphyrin IX in a colon carcinoma model.
    British journal of cancer, 1996, Volume: 73, Issue:8

    Topics: Aminolevulinic Acid; Animals; Chlorophyllides; Colonic Neoplasms; Dihematoporphyrin Ether; Female; Fluorescence; Mice; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Tissue Distribution

1996
Biodistribution of protoporphyrin IX in rat urinary bladder after intravesical instillation of 5-aminolevulinic acid.
    The Journal of urology, 1996, Volume: 155, Issue:5

    Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Female; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Tissue Distribution; Urinary Bladder

1996
Feasibility of photodynamic therapy using endogenous photosensitization for colon cancer.
    Archives of surgery (Chicago, Ill. : 1960), 1996, Volume: 131, Issue:6

    Topics: Adenocarcinoma; Administration, Oral; Aminolevulinic Acid; Biopsy; Colectomy; Colon, Sigmoid; Follow-Up Studies; Gardner Syndrome; Humans; Male; Middle Aged; Necrosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sigmoid Neoplasms; Time Factors

1996
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX.
    British journal of cancer, 1996, Volume: 74, Issue:1

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Apoptosis; Cells, Cultured; Colonic Neoplasms; Cricetinae; Cricetulus; Fibroblasts; Humans; Light; Necrosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

1996
Photodynamic therapy on the normal rabbit larynx with phthalocyanine and 5-aminolaevulinic acid induced protoporphyrin IX photosensitisation.
    British journal of cancer, 1996, Volume: 74, Issue:1

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Indoles; Larynx; Male; Microscopy, Fluorescence; Necrosis; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rabbits

1996
Formation of water-soluble porphyrins and protoporphyrin IX in 5-aminolevulinic-acid-incubated carcinoma cells.
    Journal of photochemistry and photobiology. B, Biology, 1996, Volume: 33, Issue:3

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Ehrlich Tumor; Glucose; Mice; Photolysis; Porphyrins; Protoporphyrins; Solubility; Temperature; Time Factors; Tumor Cells, Cultured; Water

1996
Accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in normal and neoplastic human endometrial epithelial cells.
    Biochemical and biophysical research communications, 1996, Jul-25, Volume: 224, Issue:3

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cells, Cultured; Endometrial Neoplasms; Endometrium; Epithelial Cells; Epithelium; Female; Flow Cytometry; Fluorescence; Humans; Protoporphyrins; Tumor Cells, Cultured

1996
The accumulation of protoporphyrin IX in plaque psoriasis after topical application of 5-aminolevulinic acid indicates a potential for superficial photodynamic therapy.
    The Journal of investigative dermatology, 1996, Volume: 107, Issue:1

    Topics: Administration, Topical; Aminolevulinic Acid; Dose-Response Relationship, Drug; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Pyrimidinones; Reference Values

1996
Eradication of high-grade dysplasia in columnar-lined (Barrett's) oesophagus by photodynamic therapy with endogenously generated protoporphyrin IX.
    Lancet (London, England), 1996, Aug-31, Volume: 348, Issue:9027

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Humans; Male; Middle Aged; Photochemotherapy; Protoporphyrins

1996
The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells.
    British journal of cancer, 1996, Volume: 74, Issue:5

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Cricetinae; Cricetulus; Dicarbethoxydihydrocollidine; Edetic Acid; Fibroblasts; Humans; Iron Chelating Agents; Microscopy, Fluorescence; Organothiophosphates; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

1996
Effects of the inhibitors of energy metabolism, lonidamine and levamisole, on 5-aminolevulinic-acid-induced photochemotherapy.
    International journal of cancer, 1996, Sep-17, Volume: 67, Issue:6

    Topics: Aminolevulinic Acid; Animals; Cell Line; Cricetinae; Cricetulus; Energy Metabolism; Indazoles; Levamisole; NAD; Nucleotides; Photochemotherapy; Protoporphyrins

1996
In vitro studies on the potential use of 5-aminolaevulinic acid-mediated photodynamic therapy for gynaecological tumours.
    British journal of cancer, 1996, Volume: 74, Issue:6

    Topics: Aminolevulinic Acid; Drug Resistance; Female; Genital Neoplasms, Female; HeLa Cells; Humans; Photochemotherapy; Protoporphyrins

1996
Dosimetry model for photodynamic therapy with topically administered photosensitizers.
    Lasers in surgery and medicine, 1996, Volume: 18, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biological Transport, Active; Dogs; Models, Biological; Optics and Photonics; Oxygen; Photochemistry; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin; Skin Absorption; Skin Neoplasms

1996
Detection of early stages of carcinogenesis in adenomas of murine lung by 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
    Photochemistry and photobiology, 1996, Volume: 64, Issue:4

    Topics: Adenoma; Aminolevulinic Acid; Animals; Bronchoscopy; Fluorescence; Fluorometry; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Photosensitizing Agents; Protoporphyrins

1996
Aminolevulinic acid for photodynamic therapy of bladder carcinoma cells.
    Urological research, 1996, Volume: 24, Issue:5

    Topics: Aminolevulinic Acid; Cell Survival; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1996
Photodynamic therapy using intravenous delta-aminolaevulinic acid-induced protoporphyrin IX sensitisation in experimental hepatic tumours in rats.
    British journal of cancer, 1996, Volume: 74, Issue:10

    Topics: Aminolevulinic Acid; Animals; Cell Division; Drug Interactions; Liver; Liver Neoplasms, Experimental; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred WF; Spectrometry, Fluorescence

1996
Selective photosensitizer localization in the human endometrium after intrauterine application of 5-aminolevulinic acid.
    American journal of obstetrics and gynecology, 1996, Volume: 175, Issue:5

    Topics: Aminolevulinic Acid; Endometrium; Female; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

1996
Iontophoretic delivery of ALA provides a quantitative model for ALA pharmacokinetics and PpIX phototoxicity in human skin.
    The Journal of investigative dermatology, 1997, Volume: 108, Issue:1

    Topics: Adult; Aminolevulinic Acid; Dose-Response Relationship, Radiation; Erythema; Female; Fluorescent Dyes; Humans; Iontophoresis; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Time Factors

1997
The effect of brief illumination on intracellular free calcium concentration in cells with 5-aminolevulinic acid-induced protoporphyrin IX synthesis.
    Scandinavian journal of clinical and laboratory investigation, 1996, Volume: 56, Issue:7

    Topics: Adenocarcinoma; Aminolevulinic Acid; Calcium; Colonic Neoplasms; Cytosol; DNA; Egtazic Acid; Fluorescent Dyes; Fura-2; Humans; Light; Protoporphyrins; Tumor Cells, Cultured

1996
Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid.
    International journal of cancer, 1997, Jan-06, Volume: 70, Issue:1

    Topics: Aminolevulinic Acid; Cells, Cultured; Humans; Photochemistry; Photosensitizing Agents; Protoporphyrins

1997
Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the detection of neoplastic lesions in the oral cavity.
    American journal of surgery, 1996, Volume: 172, Issue:6

    Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Endoscopy; Humans; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Pharyngeal Neoplasms; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

1996
In-vitro investigation of ALA-induced protoporphyrin IX.
    Journal of photochemistry and photobiology. B, Biology, 1996, Volume: 36, Issue:2

    Topics: Aminolevulinic Acid; Dose-Response Relationship, Drug; Fibroblasts; Humans; Hydrogen-Ion Concentration; Kinetics; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence

1996
Inhalation of 5-aminolevulinic acid: a new technique for fluorescence detection of early stage lung cancer.
    Journal of photochemistry and photobiology. B, Biology, 1996, Volume: 36, Issue:2

    Topics: Administration, Inhalation; Aminolevulinic Acid; Animals; Dogs; Lung Neoplasms; Protoporphyrins; Spectrometry, Fluorescence

1996
Plasma levels of protoporphyrin IX in humans after oral administration of 5-aminolevulinic acid.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 37, Issue:1-2

    Topics: Administration, Oral; Aged; Aminolevulinic Acid; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

1997
The pH dependency of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid.
    Cancer letters, 1997, Feb-26, Volume: 113, Issue:1-2

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Survival; Colonic Neoplasms; Cricetinae; Fibroblasts; Humans; Hydrogen-Ion Concentration; Lung; Proteins; Protoporphyrins; Tumor Cells, Cultured

1997
Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues.
    Cancer letters, 1997, Jan-30, Volume: 112, Issue:2

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Drug Interactions; Humans; Liver Neoplasms, Experimental; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred WF; Skin; Skin Neoplasms; Spectrometry, Fluorescence

1997
Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer.
    Urological research, 1997, Volume: 25 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopes; Cystoscopy; Evaluation Studies as Topic; Female; Fluorescence; Humans; Krypton; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder; Urinary Bladder Neoplasms; Urine; Xenon

1997
Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture.
    Cancer research, 1997, Apr-15, Volume: 57, Issue:8

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Cricetinae; Cricetulus; Drug Screening Assays, Antitumor; Esters; Female; Fibroblasts; Humans; Neoplasm Proteins; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Uterine Cervical Neoplasms

1997
5-Aminolevulinic acid (ALA)-induced protoporphyrin IX fluorescence and photodynamic effects in the rat bladder: an in vivo study comparing oral and intravesical ALA administration.
    Lasers in surgery and medicine, 1997, Volume: 20, Issue:3

    Topics: Administration, Intravesical; Administration, Oral; Aminolevulinic Acid; Animals; Female; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Rats; Rats, Wistar; Skin; Urinary Bladder

1997
Laser-induced fluorescence studies of normal and malignant tumour tissue of rat following intravenous injection of delta-amino levulinic acid.
    Lasers in surgery and medicine, 1997, Volume: 20, Issue:3

    Topics: Aminolevulinic Acid; Animals; Injections, Intravenous; Lasers; Muscles; Neoplasms, Experimental; Protoporphyrins; Rats; Rats, Inbred WF; Spectrometry, Fluorescence; Tissue Distribution; Tumor Cells, Cultured

1997
Clinical evaluation of a method for detecting superficial surgical transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following the topical application of 5-aminolevulinic acid: preliminary results.
    Lasers in surgery and medicine, 1997, Volume: 20, Issue:4

    Topics: Administration, Cutaneous; Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Evaluation Studies as Topic; Female; Fluorescence; Humans; Male; Middle Aged; Photofluorography; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms

1997
[The clinical value of fluorescence cystoscopy in the detection of superficial transitional epithelial cell carcinoma of the bladder].
    Annales d'urologie, 1997, Volume: 31, Issue:1

    Topics: Administration, Intravesical; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Transitional Cell; Cystoscopy; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Photosensitizing Agents; Prodrugs; Prognosis; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity; Urinary Bladder Neoplasms

1997
Comparison of delta-aminolaevulinic acid and its methyl ester as an inducer of porphyrin synthesis in cultured cells.
    British journal of cancer, 1997, Volume: 75, Issue:10

    Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Extracellular Space; Heme; Liver; Photosensitizing Agents; Protoporphyrins; Rats; Stimulation, Chemical

1997
The efficacy of an iron chelator (CP94) in increasing cellular protoporphyrin IX following intravesical 5-aminolaevulinic acid administration: an in vivo study.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 38, Issue:2-3

    Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Female; Iron Chelating Agents; Kinetics; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Pyridones; Rats; Rats, Wistar; Spectrometry, Fluorescence; Urinary Bladder

1997
In vivo fluorescence kinetics of porphyrins following intravesical instillation of 5-aminolaevulinic acid in normal and tumour-bearing rat bladders.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 38, Issue:2-3

    Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Female; Kinetics; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence; Urinary Bladder; Urinary Bladder Neoplasms

1997
On-line fluorescence of human tissues after oral administration of 5-aminolevulinic acid.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 38, Issue:2-3

    Topics: Administration, Oral; Aminolevulinic Acid; Drug Administration Schedule; Gastrointestinal Neoplasms; Humans; Mouth Mucosa; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Regional Blood Flow; Skin; Spectrometry, Fluorescence; Surface Properties; Tissue Distribution

1997
The importance of fluorescence distribution and kinetics of ALA-induced PpIX in the bladder in photodynamic therapy.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 38, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Female; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Urinary Bladder

1997
N-conjugates of 2,5-disubstituted pyrrole and glutathione. Evaluation of their potency as antioxidants against photosensitization of NCTC 2544 keratinocytes by excess endogenous protoporphyrin IX.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 39, Issue:1

    Topics: Aminolevulinic Acid; Antioxidants; Cell Line; Glutathione; Humans; Keratinocytes; Light; Molecular Structure; Photosensitizing Agents; Protoporphyrins; Pyrroles

1997
Photobleaching during and re-appearance after photodynamic therapy of topical ALA-induced fluorescence in UVB-treated mouse skin.
    International journal of cancer, 1997, Jul-03, Volume: 72, Issue:1

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Mice; Mice, Inbred Strains; Photochemistry; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Radiation Injuries, Experimental; Skin; Ultraviolet Rays

1997
Interstitial photodynamic therapy in the canine prostate with disulfonated aluminum phthalocyanine and 5-aminolevulinic acid-induced protoporphyrin IX.
    The Prostate, 1997, Jul-01, Volume: 32, Issue:2

    Topics: Aminolevulinic Acid; Animals; Atrophy; Collagen; Dogs; Indoles; Lasers; Light; Male; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Prostate; Prostatic Neoplasms; Protoporphyrins

1997
Correlation between plasma 5-aminolevulinic acid concentrations and indicators of oxidative stress in lead-exposed workers.
    Clinical chemistry, 1997, Volume: 43, Issue:7

    Topics: Adolescent; Adult; Aminolevulinic Acid; Humans; Lead; Luminescent Measurements; Male; Methemoglobinemia; Middle Aged; Occupational Exposure; Oxidative Stress; Protoporphyrins; Superoxide Dismutase

1997
In vivo fluorescence detection of ovarian cancer in the NuTu-19 epithelial ovarian cancer animal model using 5-aminolevulinic acid (ALA).
    Gynecologic oncology, 1997, Volume: 66, Issue:1

    Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Epithelium; Feasibility Studies; Female; Fluorescence; Image Processing, Computer-Assisted; Mice; Mice, Nude; Microscopy, Fluorescence; Ovarian Neoplasms; Peritoneal Neoplasms; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344

1997
Protoporphyrin-IX distribution and photodynamic effect in rat oesophagus after aminolaevulinic acid administration.
    Scandinavian journal of gastroenterology, 1997, Volume: 32, Issue:7

    Topics: Aminolevulinic Acid; Animals; Esophagus; Male; Microscopy, Fluorescence; Mucous Membrane; Muscle, Smooth; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Time Factors

1997
Potential efficacy of a delta 5-aminolevulinic acid bioadhesive gel formulation for the photodynamic treatment of lesions of the gastrointestinal tract in mice.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:7

    Topics: Aminolevulinic Acid; Animals; Barrett Esophagus; Biocompatible Materials; Disease Models, Animal; Fiber Optic Technology; Gallbladder; Gastric Mucosa; Gels; In Vitro Techniques; Liver; Male; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Stomach Neoplasms; Tissue Adhesives

1997
Enhancement of photodynamic therapy in gastric cancer cells by removal of iron.
    Gut, 1997, Volume: 41, Issue:1

    Topics: Aminolevulinic Acid; Cell Survival; Deferoxamine; Ferrochelatase; Humans; Iron; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Siderophores; Stomach Neoplasms; Tumor Cells, Cultured

1997
H-dependent formation of 5-aminolaevulinic acid-induced protoporphyrin IX in fibrosarcoma cells.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 40, Issue:1

    Topics: Aminolevulinic Acid; Animals; Cell Survival; Fibrosarcoma; Flow Cytometry; Hydrogen-Ion Concentration; Kinetics; Light; Mice; Photochemotherapy; Protoporphyrins; Tumor Cells, Cultured

1997
Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX.
    British journal of cancer, 1997, Volume: 76, Issue:6

    Topics: Aminolevulinic Acid; Cell Division; Cell Survival; Cells, Cultured; Culture Media; Endothelium, Vascular; Humans; Muscle, Smooth, Vascular; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Ultraviolet Rays

1997
Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells.
    British journal of cancer, 1997, Volume: 76, Issue:7

    Topics: Aminolevulinic Acid; Carcinoma; Colonic Neoplasms; Hematoporphyrins; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

1997
Effects of fractionated 5-aminolevulinic acid administration on tissue levels of protoporphyrin in vivo.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 40, Issue:2

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Mice; Photosensitizing Agents; Prodrugs; Protoporphyrins

1997
Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits.
    Magnesium research, 1997, Volume: 10, Issue:2

    Topics: Administration, Oral; Aminolevulinic Acid; Analysis of Variance; Animals; Chelating Agents; Chronic Disease; Dietary Supplements; Edetic Acid; Female; Lead; Lead Poisoning; Magnesium; Protoporphyrins; Rabbits

1997
Pharmacokinetics of 5-aminolevulinic acid-induced protoporphyrin IX in skin and blood.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 40, Issue:3

    Topics: Aged; Aminolevulinic Acid; Fluorescence; Humans; Middle Aged; Protoporphyrins; Skin

1997
Hormonal modulation of the accumulation of 5-aminolevulinic acid-induced protoporphyrin and phototoxicity in prostate cancer cells.
    International journal of cancer, 1997, Sep-17, Volume: 72, Issue:6

    Topics: Aminolevulinic Acid; Animals; Blood; Cattle; Cell Division; Cell Survival; Culture Media; Dihydrotestosterone; Estradiol; Humans; Kinetics; Male; Photochemotherapy; Prostatic Neoplasms; Protoporphyrins; Tumor Cells, Cultured

1997
Selectivity of protoporphyrin IX fluorescence for condylomata after topical application of 5-aminolaevulinic acid: implications for photodynamic treatment.
    The British journal of dermatology, 1997, Volume: 137, Issue:5

    Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Condylomata Acuminata; Humans; Male; Microscopy, Fluorescence; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence

1997
Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle.
    International journal of cancer, 1998, Jan-05, Volume: 75, Issue:1

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Communication; Cell Count; Cell Cycle; Cell Line; Colonic Neoplasms; Cricetinae; Cricetulus; Fibroblasts; Humans; Protoporphyrins; Tumor Cells, Cultured

1998
Porphyrin sensitization and intracellular calcium changes in the prokaryote Propionibacterium acnes.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 40, Issue:2

    Topics: Aminolevulinic Acid; Calcium; Fura-2; Light; Photosensitizing Agents; Porphyrins; Propionibacterium acnes; Protoporphyrins

1997
Delta-aminolevulinic acid-induced fluorescence in normal human lymphocytes.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 41, Issue:1-2

    Topics: Aminolevulinic Acid; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Fluorescence; Humans; Mitogens; Phytohemagglutinins; Pokeweed Mitogens; Prodrugs; Protoporphyrins; Spectrometry, Fluorescence

1997
Effect of continuous and multiple doses of 5-aminolevulinic acid on protoporphyrin IX concentrations in the rat uterus.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 41, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Endometrium; Female; Hydrogen-Ion Concentration; Protoporphyrins; Rats; Rats, Sprague-Dawley; Solutions; Temperature; Time Factors

1997
A hydroxypyridinone (CP94) enhances protoporphyrin IX formation in 5-aminolaevulinic acid treated cells.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 41, Issue:1-2

    Topics: Aminolevulinic Acid; Cell Line; Darkness; Humans; Iron Chelating Agents; Microscopy, Fluorescence; Molecular Structure; Prodrugs; Protoporphyrins; Pyridones; Spectrometry, Fluorescence

1997
Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect.
    Photochemistry and photobiology, 1998, Volume: 67, Issue:1

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Radiation; Fluorescence; Light; Mice; Mice, Hairless; Photochemotherapy; Protoporphyrins; Skin

1998
Derivatives of 5-aminolevulinic acid for photodynamic therapy: enzymatic conversion into protoporphyrin.
    Photochemistry and photobiology, 1998, Volume: 67, Issue:1

    Topics: Aminolevulinic Acid; Humans; Hydrolysis; Photochemotherapy; Prodrugs; Protoporphyrins; Tumor Cells, Cultured

1998
[Eradication of high-grade dysplasia in Barrett esophagus by photodynamic therapy with endogenously generated protoporphyrin IX].
    Zeitschrift fur Gastroenterologie, 1998, Volume: 36, Issue:1

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagus; Female; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins

1998
[Photodynamic diagnosis of gastrointestinal precancerous lesions after sensitization with 5-aminolevulinic acid. A pilot study].
    Deutsche medizinische Wochenschrift (1946), 1998, Apr-24, Volume: 123, Issue:17

    Topics: Adenoma; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Colitis, Ulcerative; Colorectal Neoplasms; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Photosensitizing Agents; Pilot Projects; Polyps; Precancerous Conditions; Protoporphyrins; Stomach Neoplasms

1998
Characterization of endogenous protoporphyrin IX induced by delta-aminolevulinic acid in resting and activated peripheral blood lymphocytes by four-color flow cytometry.
    Photochemistry and photobiology, 1998, Volume: 67, Issue:5

    Topics: Aminolevulinic Acid; Flow Cytometry; Humans; Immunophenotyping; Lymphocyte Activation; Lymphocytes; Protoporphyrins; Receptors, Transferrin

1998
Biodistribution of Photofrin II and 5-aminolevulinic acid-induced protoporphyrin IX in normal rat bladder and bladder tumor models: implications for photodynamic therapy.
    Photochemistry and photobiology, 1998, Volume: 67, Issue:5

    Topics: Aminolevulinic Acid; Animals; Dihematoporphyrin Ether; Disease Models, Animal; Female; Photochemotherapy; Protoporphyrins; Rats; Tissue Distribution; Tumor Cells, Cultured; Urinary Bladder; Urinary Bladder Neoplasms

1998
The influence of hypoxia and pH on aminolaevulinic acid-induced photodynamic therapy in bladder cancer cells in vitro.
    British journal of cancer, 1998, Volume: 77, Issue:10

    Topics: Acidosis; Aminolevulinic Acid; Cell Hypoxia; Cell Survival; Humans; Hydrogen-Ion Concentration; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1998
Hemodynamic effects of 5-aminolevulinic acid in humans.
    Journal of photochemistry and photobiology. B, Biology, 1998, Volume: 43, Issue:1

    Topics: Aminolevulinic Acid; Blood Pressure; Capillaries; Cardiac Output; Heart Failure; Hemodynamics; Humans; Photochemotherapy; Protoporphyrins; Pulmonary Artery; Pulmonary Wedge Pressure; Pulse; Vascular Resistance

1998
Cell cycle phase influences tumour cell sensitivity to aminolaevulinic acid-induced photodynamic therapy in vitro.
    British journal of cancer, 1998, Volume: 78, Issue:1

    Topics: Aminolevulinic Acid; Cell Cycle; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1998
Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes.
    British journal of cancer, 1998, Volume: 77, Issue:11

    Topics: Aminolevulinic Acid; Animals; Calcium; Cell Differentiation; Heme; Keratinocytes; Mice; Photochemotherapy; Porphobilinogen Synthase; Protoporphyrins; Rats; RNA, Messenger

1998
Delta-aminolevulinic acid-mediated photosensitization of prostate cell lines: implication for photodynamic therapy of prostate cancer.
    The Prostate, 1998, Sep-01, Volume: 36, Issue:4

    Topics: Aminolevulinic Acid; Cell Survival; Humans; Male; Microscopy, Electron; Mitochondria; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Tumor Cells, Cultured

1998
Biochemical basis of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus.
    British journal of cancer, 1998, Volume: 78, Issue:5

    Topics: Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagus; Female; Ferrochelatase; Humans; Hydroxymethylbilane Synthase; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Prodrugs; Protoporphyrins

1998
5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration.
    Journal of photochemistry and photobiology. B, Biology, 1998, Jun-15, Volume: 44, Issue:1

    Topics: Administration, Oral; Alanine Transaminase; Aminolevulinic Acid; Animals; Aspartate Aminotransferases; Creatinine; Injections, Intravenous; Kidney Function Tests; Male; Microscopy, Confocal; Photosensitizing Agents; Porphobilinogen; Protoporphyrins; Rats; Rats, Inbred Strains; Tissue Distribution; Urea

1998
Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound.
    International journal of cancer, 1998, Nov-09, Volume: 78, Issue:4

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; Protoporphyrins; Tumor Cells, Cultured; Ultrasonics

1998
Intra-arterial photodynamic therapy using 5-ALA in a swine model.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 1998, Volume: 16, Issue:4

    Topics: Aminolevulinic Acid; Angioplasty, Balloon; Animals; Carotid Arteries; Catheterization; Iliac Artery; Muscle, Smooth, Vascular; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Recurrence; Swine; Time Factors

1998
Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue.
    Acta neurochirurgica, 1998, Volume: 140, Issue:10

    Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Microsurgery; Protoporphyrins; Sensitivity and Specificity

1998
Antigen specific and nonspecific modulation of the immune response by aminolevulinic acid based photodynamic therapy.
    Immunopharmacology, 1998, Volume: 40, Issue:3

    Topics: Aminolevulinic Acid; Dendritic Cells; HLA-D Antigens; Humans; Lymphocytes; Macrophages; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

1998
Kinetics of photobleaching of protoporphyrin IX in the skin of nude mice exposed to different fluence rates of red light.
    Photochemistry and photobiology, 1998, Volume: 68, Issue:6

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Kinetics; Light; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemistry; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence

1998
Expression kinetics of the (proto) oncogenes c-myc and bcl-2 following photodynamic treatment of normal and transformed human fibroblasts with 5-aminolaevulinic acid-stimulated endogenous protoporphyrin IX.
    Journal of photochemistry and photobiology. B, Biology, 1998, Volume: 45, Issue:2-3

    Topics: Aminolevulinic Acid; Cell Line; Cell Line, Transformed; Fibroblasts; Gene Expression; Humans; Kinetics; Photosensitizing Agents; Proto-Oncogene Mas; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Protoporphyrins

1998
In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid.
    Journal of photochemistry and photobiology. B, Biology, 1998, Volume: 45, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Glioma; Humans; Male; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Tumor Cells, Cultured

1998
Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis, or adenomatous polyps after 5-aminolevulinic acid-induced protoporphyrin IX sensitization.
    Gastrointestinal endoscopy, 1999, Volume: 49, Issue:1

    Topics: Adenomatous Polyps; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Biopsy; Colitis, Ulcerative; Diagnosis, Differential; Endoscopy, Gastrointestinal; Female; Follow-Up Studies; Humans; Male; Metaplasia; Microscopy, Fluorescence; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Rectal Neoplasms

1999
Selective destruction of leukaemic cells by photo-activation of 5-aminolaevulinic acid-induced protoporphyrin-IX.
    Journal of photochemistry and photobiology. B, Biology, 1998, Volume: 47, Issue:1

    Topics: Aminolevulinic Acid; Bone Marrow Cells; Cell Division; Cell Survival; Hematopoietic Stem Cells; HL-60 Cells; Humans; Jurkat Cells; Leukemia; Photosensitizing Agents; Protoporphyrins; Time Factors; Tumor Cells, Cultured

1998
Protoporphyrin IX fluorescence photobleaching during ALA-mediated photodynamic therapy of UVB-induced tumors in hairless mouse skin.
    Photochemistry and photobiology, 1999, Volume: 69, Issue:1

    Topics: Aminolevulinic Acid; Animals; Female; Fluorescence; Male; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Photobiology; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Ultraviolet Rays

1999
Timing of illumination is essential for effective and safe photodynamic therapy: a study in the normal rat oesophagus.
    British journal of cancer, 1999, Volume: 79, Issue:5-6

    Topics: Aminolevulinic Acid; Animals; Edema; Esophagus; Light; Male; Mucous Membrane; Muscle, Smooth; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence; Time Factors

1999
Fluorescence diagnostics and kinetic studies in the head and neck region utilizing low-dose delta-aminolevulinic acid sensitization.
    Cancer letters, 1999, Jan-08, Volume: 135, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Dose-Response Relationship, Drug; Endoscopy; Female; Head and Neck Neoplasms; Humans; Lasers; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

1999
Protoporphyrin IX-sensitized photoinactivation of 5-aminolevulinate-treated leukemia cells: effects of exogenous iron.
    Photochemistry and photobiology, 1999, Volume: 69, Issue:3

    Topics: Aminolevulinic Acid; Animals; Ferric Compounds; Hydroxyquinolines; Leukemia L1210; Mice; Photochemotherapy; Porphyrins; Protoporphyrins; Tumor Cells, Cultured

1999
Effect of 2,2'-dipyridyl on accumulation of protoporphyrin IX and its derivatives in yeast mitochondria and plasma membranes.
    Biochemistry. Biokhimiia, 1999, Volume: 64, Issue:2

    Topics: 2,2'-Dipyridyl; Aminolevulinic Acid; Cell Membrane; Iron Chelating Agents; Mitochondria; Photosensitizing Agents; Protoporphyrins; Saccharomyces cerevisiae; Spectrometry, Fluorescence

1999
Hypoxia significantly reduces aminolaevulinic acid-induced protoporphyrin IX synthesis in EMT6 cells.
    British journal of cancer, 1999, Volume: 79, Issue:9-10

    Topics: Aminolevulinic Acid; Cell Count; Cell Division; Cell Hypoxia; Protoporphyrins; Tumor Cells, Cultured

1999
The iron regulatory protein can determine the effectiveness of 5-aminolevulinic acid in inducing protoporphyrin IX in human primary skin fibroblasts.
    The Journal of investigative dermatology, 1999, Volume: 112, Issue:4

    Topics: Aminolevulinic Acid; Cells, Cultured; Deferoxamine; Humans; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Photochemotherapy; Protoporphyrins; RNA; RNA-Binding Proteins; Skin; Ultraviolet Rays

1999
Uptake of topically applied 5-aminolevulinic acid and production of protoporphyrin IX in normal mouse skin: dependence on skin temperature.
    Photochemistry and photobiology, 1999, Volume: 69, Issue:4

    Topics: Aminolevulinic Acid; Animals; Female; Mice; Mice, Hairless; Mice, Inbred BALB C; Photobiology; Photochemotherapy; Protoporphyrins; Skin; Skin Temperature

1999
Kidney-preserving tumour resection in renal cell carcinoma with photodynamic detection by 5-aminolaevulinic acid: preclinical and preliminary clinical results.
    BJU international, 1999, Volume: 83, Issue:6

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Transplantation, Heterologous; Tumor Cells, Cultured

1999
Active and higher intracellular uptake of 5-aminolevulinic acid in tumors may be inhibited by glycine.
    The Journal of investigative dermatology, 1999, Volume: 112, Issue:5

    Topics: Aminolevulinic Acid; Animals; Biological Transport; Cricetinae; Deferoxamine; Diffusion Chambers, Culture; Glycine; Male; Melanoma, Amelanotic; Mesocricetus; Neoplasm Transplantation; Phenanthrolines; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence

1999
Rodent fibroblast model for studies of response of malignant cells to exogenous 5-aminolevulinic acid.
    British journal of cancer, 1999, Volume: 80, Issue:5-6

    Topics: 3T3 Cells; Aminolevulinic Acid; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Female; Fibroblasts; Fibrosarcoma; Flow Cytometry; Fluorescent Dyes; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Oncogenes; Phenotype; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Signal Transduction; Species Specificity; Spectrometry, Fluorescence; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1999
Delta-aminolaevulinic acid-induced photodynamic therapy inhibits protoporphyrin IX biosynthesis and reduces subsequent treatment efficacy in vitro.
    British journal of cancer, 1999, Volume: 80, Issue:7

    Topics: Aminolevulinic Acid; Animals; Cell Division; Cell Survival; Hydroxymethylbilane Synthase; Light; Photosensitizing Agents; Protoporphyrins; Rats; Treatment Outcome

1999
Photodynamically induced effects in colon carcinoma cells (WiDr) by endogenous photosensitizers generated by incubation with 5-aminolaevulinic acid.
    Journal of photochemistry and photobiology. B, Biology, 1999, Volume: 49, Issue:2-3

    Topics: Adenosine Triphosphate; Aminolevulinic Acid; Biomarkers, Tumor; Colonic Neoplasms; Fluorescent Dyes; Heptanoates; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Oxygen Consumption; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rhodamine 123; Time Factors; Tumor Cells, Cultured

1999
Comparative effect of ALA derivatives on protoporphyrin IX production in human and rat skin organ cultures.
    British journal of cancer, 1999, Volume: 80, Issue:10

    Topics: Aminolevulinic Acid; Animals; Female; Humans; Microscopy, Fluorescence; Organ Culture Techniques; Protoporphyrins; Rats; Rats, Wistar; Skin

1999
Optimisation of the formation and distribution of protoporphyrin IX in the urothelium: an in vitro approach.
    The Journal of urology, 1999, Volume: 162, Issue:2

    Topics: Aminolevulinic Acid; Animals; Humans; Photosensitizing Agents; Protoporphyrins; Swine; Tissue Distribution; Urothelium

1999
Three-dimensional in vitro cocultivation of lung carcinoma cells with human bronchial organ culture as a model for bronchial carcinoma.
    American journal of respiratory cell and molecular biology, 1999, Volume: 21, Issue:2

    Topics: Aminolevulinic Acid; Bronchi; Bronchial Neoplasms; Carcinoma, Non-Small-Cell Lung; Coculture Techniques; Humans; Kinetics; Lung Neoplasms; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Models, Biological; Organ Culture Techniques; Protoporphyrins; Time Factors; Tumor Cells, Cultured

1999
Endoscopic photodynamic diagnosis: oral aminolevulinic acid is a marker of GI cancer and dysplastic lesions.
    Gastrointestinal endoscopy, 1999, Volume: 50, Issue:2

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Duodenal Neoplasms; Endoscopy, Digestive System; Equipment Design; Esophageal Neoplasms; Female; Fluorescence; Humans; Male; Middle Aged; Neoplasm Staging; Photography; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Stomach Neoplasms

1999
Protoporphyrin IX fluorescence kinetics in C6 glioblastoma cells after delta-aminolevulinic acid incubation: effect of a protoporphyrinogen oxidase inhibitor.
    Cellular and molecular biology (Noisy-le-Grand, France), 1999, Volume: 45, Issue:4

    Topics: Aminolevulinic Acid; Animals; Enzyme Inhibitors; Fluorescence; Glioblastoma; Humans; Kinetics; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Photosensitizing Agents; Protoporphyrinogen Oxidase; Protoporphyrins; Rats; Sulfonamides; Triazoles; Tumor Cells, Cultured

1999
delta-Aminolaevulinic acid-induced porphyrin synthesis and photodynamic inactivation of Escherichia coli B.
    Journal of photochemistry and photobiology. B, Biology, 1999, Volume: 50, Issue:1

    Topics: Aminolevulinic Acid; Coproporphyrins; Darkness; Dose-Response Relationship, Drug; Escherichia coli; Mesoporphyrins; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Time Factors

1999
[Visualizing carcinomas of the mouth cavity by stimulating synthesis of fluorescent protoporphyrin IX].
    Mund-, Kiefer- und Gesichtschirurgie : MKG, 1999, Volume: 3, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Female; Humans; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasm Staging; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence

1999
Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA.
    Photochemistry and photobiology, 1999, Volume: 70, Issue:3

    Topics: Aminolevulinic Acid; Breast Neoplasms; DNA; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylbilane Synthase; Mesothelioma; Photochemotherapy; Plasmids; Protoporphyrins; Transfection; Tumor Cells, Cultured

1999
The temperature dependence of protoporphyrin IX production in cells and tissues.
    Photochemistry and photobiology, 1999, Volume: 70, Issue:4

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Cell Line; Cricetinae; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Protoporphyrins; Skin; Skin Neoplasms; Temperature

1999
Relationship of delta-aminolevulinic acid-induced protoporphyrin IX levels to mitochondrial content in neoplastic cells in vitro.
    Biochemical and biophysical research communications, 1999, Nov-19, Volume: 265, Issue:2

    Topics: Aminolevulinic Acid; Animals; Electron Transport Complex IV; Ferrochelatase; Fluorescent Dyes; Humans; Hydroxymethylbilane Synthase; Mice; Mitochondria; Neoplasms; Oxidoreductases; Photochemotherapy; Photosensitizing Agents; Porphobilinogen Synthase; Protoporphyrins; Tumor Cells, Cultured

1999
Preclinical study in cats of the pro-photosensitizer 5-aminolevulinic acid.
    American journal of veterinary research, 1999, Volume: 60, Issue:11

    Topics: Aminolevulinic Acid; Animals; Biotransformation; Carcinoma, Squamous Cell; Cat Diseases; Cats; Cell Line; Female; Kidney; Male; Orchiectomy; Ovariectomy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms

1999
Effect of estrogenic perturbations on delta-aminolevulinic acid-induced porphobilinogen deaminase and protoporphyrin IX levels in rat Harderian glands, liver, and R3230AC tumors.
    Biochemical pharmacology, 1999, Dec-01, Volume: 58, Issue:11

    Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Estrogen Antagonists; Estrogens; Female; Harderian Gland; Hydroxymethylbilane Synthase; Liver; Mammary Neoplasms, Experimental; Ovariectomy; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred F344; Tamoxifen

1999
Detection of squamous cell carcinoma of the oral cavity by imaging 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
    The Laryngoscope, 2000, Volume: 110, Issue:1

    Topics: Adult; Aged; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Humans; Middle Aged; Mouth; Mouth Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Solutions; Spectrometry, Fluorescence; Time Factors

2000
Local 5-aminolevulinic acid application for laser light-induced fluorescence diagnosis of early staged colon cancer in rats.
    Lasers in surgery and medicine, 2000, Volume: 26, Issue:3

    Topics: 1,2-Dimethylhydrazine; Aminolevulinic Acid; Animals; Biomarkers, Tumor; Colon; Colonic Neoplasms; Colonoscopy; Fluorescence; Lasers; Male; Photosensitizing Agents; Predictive Value of Tests; Protoporphyrins; Rats; Rats, Wistar; Therapeutic Irrigation

2000
5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells.
    Journal of photochemistry and photobiology. B, Biology, 2000, Volume: 54, Issue:1

    Topics: Aminolevulinic Acid; Bronchi; Cell Line; Humans; Hydrogen-Ion Concentration; Kinetics; Lung Neoplasms; Photosensitizing Agents; Protoporphyrins; Respiratory Mucosa; Structure-Activity Relationship; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2000
Decreased and increased expression of the subunit CHL I diminishes Mg chelatase activity and reduces chlorophyll synthesis in transgenic tobacco plants.
    The Plant journal : for cell and molecular biology, 2000, Volume: 22, Issue:2

    Topics: Aminolevulinic Acid; Blotting, Northern; Blotting, Western; Catalytic Domain; Chlorophyll; Light-Harvesting Protein Complexes; Lyases; Nicotiana; Photosynthetic Reaction Center Complex Proteins; Plants, Genetically Modified; Plants, Toxic; Protoporphyrins; Pyrroles; Tetrapyrroles

2000
A study of aminolevulinic acid-induced protoporphyrin IX fluorescence kinetics in the canine oral cavity.
    Lasers in surgery and medicine, 2000, Volume: 26, Issue:4

    Topics: Aminolevulinic Acid; Animals; Dogs; Dose-Response Relationship, Drug; Face; Female; Fiber Optic Technology; Fluorescence; Gingiva; Heme; Image Processing, Computer-Assisted; Mouth; Mouth Mucosa; Photosensitizing Agents; Protoporphyrins; Random Allocation; Skin; Spectrometry, Fluorescence; Time Factors; Tongue

2000
The morphological changes in rat bladder after photodynamic therapy with 5-aminolaevulinic acid-induced protoporphyrin IX.
    BJU international, 2000, Volume: 86, Issue:1

    Topics: Aminolevulinic Acid; Animals; Female; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Urinary Bladder Diseases

2000
Photodynamic therapy of human glioma spheroids using 5-aminolevulinic acid.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:1

    Topics: Aminolevulinic Acid; Glioblastoma; Humans; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins; Spheroids, Cellular

2000
Photodynamic therapy of cutaneous lymphoma using 5-aminolevulinic acid topical application.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2000, Volume: 26, Issue:8

    Topics: Abdomen; Administration, Topical; Adult; Aged; Aminolevulinic Acid; Facial Dermatoses; Humans; Lymphoma, T-Cell, Cutaneous; Male; Mycosis Fungoides; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence

2000
Effect of photodynamic therapy in combination with ionizing radiation on human squamous cell carcinoma cell lines of the head and neck.
    British journal of cancer, 2000, Volume: 83, Issue:5

    Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Combined Modality Therapy; DNA; Dose-Response Relationship, Radiation; Gamma Rays; Head and Neck Neoplasms; Humans; Kinetics; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation, Ionizing; Time Factors; Tumor Cells, Cultured

2000
Porphyrin biosynthesis in human Barrett's oesophagus and adenocarcinoma after ingestion of 5-aminolaevulinic acid.
    British journal of cancer, 2000, Volume: 83, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Female; Ferrochelatase; Heme; Humans; Hydroxymethylbilane Synthase; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Porphobilinogen; Porphyrins; Protoporphyrins

2000
Phototransformations of 5-aminolevulinic acid-induced protoporphyrin IX in vitro: a spectroscopic study.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:2

    Topics: Aminolevulinic Acid; Humans; In Vitro Techniques; Lasers; Photochemistry; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured

2000
Intravesical administration of 5-aminolevulinic acid (5-ALA). Safety and pharmacokinetics of 5-ALA and its metabolite protoporphyrin IX.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:3

    Topics: Administration, Intravesical; Adult; Aged; Aminolevulinic Acid; Female; Humans; Male; Middle Aged; Protoporphyrins; Urinary Bladder; Urinary Bladder Neoplasms

2000
Genes involved in the destruction of leukaemic cells by induced photosensitivity.
    Folia biologica, 2000, Volume: 46, Issue:4

    Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; DNA, Complementary; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Light; Oligonucleotide Array Sequence Analysis; Photosensitizing Agents; Protoporphyrins; Transcription, Genetic; Tumor Cells, Cultured

2000
Protoporphyrin IX fluorescence kinetics and localization after topical application of ALA pentyl ester and ALA on hairless mouse skin with UVB-induced early skin cancer.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Fluorescence; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms

2000
Initial experience in the treatment of oral leukoplakia with high-dose vitamin A and follow-up 5-aminolevulinic acid induced protoporphyrin IX fluorescence.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2000, Volume: 257, Issue:6

    Topics: Adult; Aminolevulinic Acid; Anticarcinogenic Agents; Diterpenes; Female; Fluorescence; Humans; Leukoplakia, Oral; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Retinyl Esters; Vitamin A

2000
Apoptosis induced in vivo by photodynamic therapy in normal brain and intracranial tumour tissue.
    British journal of cancer, 2000, Volume: 83, Issue:8

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Dihematoporphyrin Ether; Indoles; Male; Mesoporphyrins; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rabbits; Radiation-Sensitizing Agents

2000
A key role for the mitochondrial benzodiazepine receptor in cellular photosensitisation with delta-aminolaevulinic acid.
    European journal of pharmacology, 2000, Oct-13, Volume: 406, Issue:2

    Topics: Aminolevulinic Acid; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fluorescence; Heme; Humans; Mitochondria; Photosensitizing Agents; Protoporphyrins; Rats; Receptors, GABA-A; Tumor Cells, Cultured

2000
Comparison of the pharmacokinetics and phototoxicity of protoporphyrin IX metabolized from 5-aminolevulinic acid and two derivatives in human skin in vivo.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:4

    Topics: Adult; Aminolevulinic Acid; Humans; Iontophoresis; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin

2000
Accumulation of protoporphyrin-IX (PpIX) in leukemic cell lines following induction by 5-aminolevulinic acid (ALA).
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2000, Volume: 126, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cattle; Culture Media; Ferrochelatase; HL-60 Cells; Humans; Jurkat Cells; Kinetics; Leukemia; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2000
Photosensitization of pancreatic tumour cells by delta-aminolaevulinic acid esters.
    Anti-cancer drug design, 2000, Volume: 15, Issue:3

    Topics: Aminolevulinic Acid; Animals; Biological Transport, Active; Carrier Proteins; Esters; Pancreatic Neoplasms; Peptide Transporter 1; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Spectrometry, Fluorescence; Structure-Activity Relationship; Symporters; Tumor Cells, Cultured

2000
Fractionated illumination in oesophageal ALA-PDT: effect on ferrochelatase activity.
    Journal of photochemistry and photobiology. B, Biology, 2000, Volume: 56, Issue:1

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Radiation; Esophagus; Ferrochelatase; Hydroxymethylbilane Synthase; Light; Male; Mucous Membrane; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar

2000
Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: differences in protoporphyrin IX fluorescence kinetics and the role of the stratum corneum.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:5

    Topics: Aminolevulinic Acid; Animals; Female; Fluorescence; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2000
Ethylene glycol and amino acid derivatives of 5-aminolevulinic acid as new photosensitizing precursors of protoporphyrin IX in cells.
    Journal of medicinal chemistry, 2000, Dec-14, Volume: 43, Issue:25

    Topics: Amino Acids; Aminolevulinic Acid; Aminopeptidases; Animals; Dipeptides; Ethylene Glycols; Fluorescence; Glutamyl Aminopeptidase; Humans; Photosensitizing Agents; Protein Precursors; Protoporphyrins; Rats; Tumor Cells, Cultured

2000
Fluorescence detection of small gastrointestinal tumours: principles, technique, first clinical experience.
    Langenbeck's archives of surgery, 2000, Volume: 385, Issue:7

    Topics: Aminolevulinic Acid; Endoscopy; Fluorescence; Gastrointestinal Neoplasms; Humans; Laparoscopy; Peritoneal Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Stomach Neoplasms

2000
Topical 5-aminolevulinic acid-photodynamic therapy of hairless mouse skin using two-fold illumination schemes: PpIX fluorescence kinetics, photobleaching and biological effect.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:6

    Topics: Aminolevulinic Acid; Animals; Fluorescence; Kinetics; Mice; Mice, Hairless; Photochemotherapy; Protoporphyrins; Skin

2000
Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo.
    Photochemistry and photobiology, 2001, Volume: 73, Issue:1

    Topics: Aminolevulinic Acid; Animals; Female; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred F344; Skin; Spectrometry, Fluorescence

2001
Regulation of protoporphyrin IX biosynthesis by intraplastidic compartmentalization and adenosine triphosphate.
    Planta, 2000, Volume: 212, Issue:1

    Topics: Adenine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Aminolevulinic Acid; Chemical Fractionation; Chloroplasts; Cucumis sativus; Dithiothreitol; Hydroxamic Acids; Hydroxymethylbilane Synthase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plastids; Porphobilinogen Synthase; Protoporphyrinogen Oxidase; Protoporphyrins; Thylakoids

2000
Oxygen monitoring during 5-aminolaevulinic acid induced photodynamic therapy in normal rat colon. Comparison of continuous and fractionated light regimes.
    Journal of photochemistry and photobiology. B, Biology, 2000, Volume: 58, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Colon; Female; Light; Monitoring, Physiologic; Necrosis; Oxygen; Photobiology; Photochemotherapy; Protoporphyrins; Rats; Rats, Wistar

2000
On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters.
    International journal of cancer, 2001, Apr-01, Volume: 92, Issue:1

    Topics: Adenocarcinoma; Administration, Cutaneous; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Protoporphyrins; Skin; Spectrometry, Fluorescence

2001
Synergistic toxicity of delta-aminolaevulinic acid-induced protoporphyrin IX used for photodiagnosis and hypericum extract, a herbal antidepressant.
    The British journal of dermatology, 2001, Volume: 144, Issue:4

    Topics: Aminolevulinic Acid; Drug Eruptions; Drug Synergism; Female; Humans; Hypericum; Middle Aged; Photosensitivity Disorders; Photosensitizing Agents; Plants, Medicinal; Protoporphyrins

2001
Photodynamic DNA damage mediated by delta-aminolevulinic acid-induced porphyrins.
    Carcinogenesis, 2001, Volume: 22, Issue:5

    Topics: Aminolevulinic Acid; Animals; DNA Damage; Humans; Mice; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured

2001
Photomodification of the electrical properties of the plasma membrane: a comparison between 6 different membrane-active photosensitizers.
    The Journal of membrane biology, 2001, May-01, Volume: 181, Issue:1

    Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Membrane; Dihematoporphyrin Ether; Electric Conductivity; Indoles; Ion Transport; Isoindoles; Kidney; Light; Membrane Potentials; Methylene Blue; Opossums; Organometallic Compounds; Patch-Clamp Techniques; Photochemistry; Photosensitizing Agents; Protoporphyrins; Pyrimidinones; Rose Bengal; Zinc Compounds

2001
Biosynthesis and photodynamic efficacy of protoporphyrin IX (PpIX) generated by 5-aminolevulinic acid (ALA) or its hexylester (hALA) in rat bladder carcinoma cells.
    Journal of photochemistry and photobiology. B, Biology, 2000, Volume: 59, Issue:1-3

    Topics: Aminolevulinic Acid; Animals; Cell Extracts; Cell Survival; Culture Media; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2000
Optimization of differential photodynamic effectiveness between normal and tumor urothelial cells using 5-aminolevulinic acid-induced protoporphyrin IX as sensitizer.
    International journal of cancer, 2001, Jun-01, Volume: 92, Issue:5

    Topics: Aminolevulinic Acid; Flow Cytometry; Humans; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Urinary Bladder; Urinary Bladder Neoplasms

2001
A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose-controlled delivery of the prodrugs 5-aminolaevulinic acid and 5-aminolaevulinic acid-n-pentylester.
    The British journal of dermatology, 2001, Volume: 144, Issue:5

    Topics: Adult; Aminolevulinic Acid; Dose-Response Relationship, Drug; Erythema; Female; Humans; Iontophoresis; Male; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin

2001
Routine experimental system for defining conditions used in photodynamic therapy and fluorescence photodetection of (non-) neoplastic epithelia.
    Journal of biomedical optics, 2001, Volume: 6, Issue:2

    Topics: Aminolevulinic Acid; Animals; Cell Death; Culture Techniques; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Mucous Membrane; Neoplasms; Paranasal Sinuses; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Respiratory Mucosa; Sheep; Swine; Time Factors; Urinary Bladder

2001
Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence microscopic studies.
    Journal of photochemistry and photobiology. B, Biology, 2001, Volume: 60, Issue:1

    Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Squamous Cell; Fluorescence; Humans; Microscopy, Fluorescence; Mouth Neoplasms; Photosensitizing Agents; Protoporphyrins; Staining and Labeling

2001
Evaluation of protoporphyrin IX production, phototoxicity and cell death pathway induced by hexylester of 5-aminolevulinic acid in Reh and HPB-ALL cells.
    Cancer letters, 2001, Aug-10, Volume: 169, Issue:1

    Topics: Aminolevulinic Acid; Cell Death; Flow Cytometry; Humans; Leukemia, B-Cell; Lymphoma, T-Cell; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2001
Modulator of heme biosynthesis induces apoptosis in leukemia cells.
    Journal of clinical laser medicine & surgery, 2001, Volume: 19, Issue:2

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Cycle; Cell Division; Cell Membrane Permeability; Cell Survival; Darkness; DNA; Flow Cytometry; Hylobates; Iron Chelating Agents; Leukemia; Light; Lymphoma; Matched-Pair Analysis; Nucleosomes; Phenanthrolines; Photosensitizing Agents; Protoporphyrins; Receptors, GABA-A; Tumor Cells, Cultured

2001
5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells.
    Journal of photochemistry and photobiology. B, Biology, 2001, Volume: 60, Issue:2-3

    Topics: Aminolevulinic Acid; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dermatitis, Phototoxic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Extracellular Space; Ferrochelatase; Half-Life; Humans; Leukemia; Photochemotherapy; Protoporphyrins; Tumor Cells, Cultured

2001
The photosensitizing effect of the photoproduct of protoporphyrin IX.
    Journal of photochemistry and photobiology. B, Biology, 2001, Volume: 60, Issue:2-3

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Membrane; Humans; Methylene Blue; Photochemotherapy; Propidium; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured

2001
An affordable, portable fluorescence imaging device for skin lesion detection using a dual wavelength approach for image contrast enhancement and aminolaevulinic acid-induced protoporphyrin IX. Part I. Design, spectral and spatial characteristics.
    Lasers in medical science, 2001, Volume: 16, Issue:3

    Topics: Aminolevulinic Acid; Equipment Design; Humans; Image Processing, Computer-Assisted; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Skin Diseases; Spectrometry, Fluorescence

2001
An affordable, portable fluorescence imaging device for skin lesion detection using a dual wavelength approach for image contrast enhancement and aminolaevulinic acid-induced protoporphyrin IX. Part II. In vivo testing.
    Lasers in medical science, 2001, Volume: 16, Issue:3

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Female; Humans; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Spectrometry, Fluorescence

2001
In vivo pharmacokinetics of protoporphyrin IX accumulation following intracutaneous injection of 5-aminolevulinic acid.
    Journal of photochemistry and photobiology. B, Biology, 2001, Aug-15, Volume: 61, Issue:1-2

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Drug Interactions; Female; Fluorescence; Injections; Kinetics; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Swine

2001
Fluorescence spectroscopy of normal mouse skin exposed to 5-aminolaevulinic acid and red light.
    Journal of photochemistry and photobiology. B, Biology, 2001, Aug-15, Volume: 61, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Female; Fluorescence; Kinetics; Light; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence

2001
Fractionated illumination for oesophageal ALA-PDT: effect on blood flow and PpIX formation.
    Lasers in medical science, 2001, Volume: 16, Issue:1

    Topics: Aminolevulinic Acid; Animals; Barrett Esophagus; Esophagus; Male; Photochemotherapy; Protoporphyrins; Rats; Rats, Wistar

2001
ALA- and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumour spheroids.
    British journal of cancer, 2001, Sep-01, Volume: 85, Issue:5

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Esters; Mammary Neoplasms, Experimental; Mice; Microscopy, Fluorescence; Oxygen; Photosensitizing Agents; Protoporphyrins; Spheroids, Cellular

2001
In vitro and in vivo expression of protoporphyrin IX induced by lipophilic 5-aminolevulinic acid derivatives.
    Journal of dermatological science, 2001, Volume: 27, Issue:2

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cells, Cultured; HeLa Cells; Humans; Keratinocytes; Kinetics; Male; Mice; Mice, Inbred C3H; Protoporphyrins; Structure-Activity Relationship; Tumor Cells, Cultured

2001
5-Aminolevulinic acid-based photochemical internalization of the immunotoxin MOC31-gelonin generates synergistic cytotoxic effects in vitro.
    Photochemistry and photobiology, 2001, Volume: 74, Issue:2

    Topics: Acetylglucosaminidase; Aminolevulinic Acid; Humans; Immunotoxins; In Vitro Techniques; Photochemistry; Photochemotherapy; Plant Proteins; Protoporphyrins; Ribosome Inactivating Proteins, Type 1; Tumor Cells, Cultured

2001
A mathematical evaluation of dose-dependent PpIX fluorescence kinetics in vivo.
    Photochemistry and photobiology, 2001, Volume: 74, Issue:2

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Fluorescence; Kinetics; Mathematics; Mice; Models, Biological; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2001
Oral aminolevulinic acid induces protoporphyrin IX fluorescence in psoriatic plaques and peripheral blood cells.
    Photochemistry and photobiology, 2001, Volume: 74, Issue:2

    Topics: Administration, Oral; Aminolevulinic Acid; Blood Cells; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Skin

2001
Autofluorescence imaging to optimize 5-ALA-induced fluorescence endoscopy of bladder carcinoma.
    Urology, 2001, Volume: 58, Issue:3

    Topics: Administration, Intravesical; Aminolevulinic Acid; Biopsy; Cystoscopy; Equipment Design; False Positive Reactions; Fluorescence; Humans; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium

2001
Intraoperative fluorescence visualization of the parathyroid gland in rats.
    Endocrinology, 2001, Volume: 142, Issue:11

    Topics: Aminolevulinic Acid; Animals; Biopsy; Female; Fluorescence; Intraoperative Period; Parathyroid Glands; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred Strains

2001
Fluorescence induced with 5-aminolevulinic acid for the endoscopic detection and follow-up of esophageal lesions.
    Gastrointestinal endoscopy, 2001, Volume: 54, Issue:5

    Topics: Administration, Oral; Aged; Aminolevulinic Acid; Biopsy; Esophageal Neoplasms; Esophagoscopy; Female; Fluorescence; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity

2001
Photodynamic effects induced by aminolevulinic acid esters on human cervical carcinoma cells in culture.
    Photochemistry and photobiology, 2001, Volume: 74, Issue:4

    Topics: Aminolevulinic Acid; Annexin A5; Apoptosis; Carcinoma in Situ; Cell Membrane; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Esters; Female; Flow Cytometry; Humans; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, X-Ray Emission; Tumor Cells, Cultured; Uterine Cervical Neoplasms

2001
Effects of 5-aminolaevulinic acid on human ovarian cancer cells and human vascular endothelial cells in vitro.
    Journal of photochemistry and photobiology. B, Biology, 2001, Nov-01, Volume: 64, Issue:1

    Topics: Aminolevulinic Acid; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cystadenocarcinoma, Mucinous; Dose-Response Relationship, Drug; Endothelium, Vascular; Epithelial Cells; Female; Humans; Kinetics; Light; Mitochondria; Ovarian Neoplasms; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Tumor Cells, Cultured; Umbilical Veins

2001
Protoporphyrin IX distribution following local application of 5-aminolevulinic acid and its esterified derivatives in the tissue layers of the normal rat colon.
    British journal of cancer, 2001, Nov-16, Volume: 85, Issue:10

    Topics: Aminolevulinic Acid; Animals; Colon; Female; Kinetics; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Rats; Tissue Distribution

2001
The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines.
    Photochemistry and photobiology, 2001, Volume: 74, Issue:5

    Topics: Adenocarcinoma; Aminolevulinic Acid; Dose-Response Relationship, Drug; Esters; Fibroblasts; Flow Cytometry; Humans; Kinetics; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2001
Endogenous production of protoporphyrin IX induced by 5-aminolevulinic acid in leukemia cells.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:2

    Topics: Aminolevulinic Acid; Animals; Leukemia, Experimental; Leukemia, Myeloid; Mice; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2001
ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitization.
    British journal of cancer, 2001, Nov-30, Volume: 85, Issue:11

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Female; Kidney; Liver; Mice; Neoplasms, Experimental; Papilloma; Photochemotherapy; Protoporphyrins; Skin; Skin Neoplasms; Spleen

2001
A comparative study of normal inspection, autofluorescence and 5-ALA-induced PPIX fluorescence for oral cancer diagnosis.
    International journal of cancer, 2002, Jan-10, Volume: 97, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Female; Fluorescence; Humans; Middle Aged; Mouth Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Time Factors

2002
The influence of UV exposure on 5-aminolevulinic acid-induced protoporphyrin IX production in skin.
    Photochemistry and photobiology, 2001, Volume: 74, Issue:6

    Topics: Aminolevulinic Acid; Animals; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Photobiology; Photochemotherapy; Protoporphyrins; Skin; Ultraviolet Rays

2001
Laparoscopic fluorescence diagnosis for intraabdominal fluorescence targeting of peritoneal carcinosis experimental studies.
    Annals of surgery, 2002, Volume: 235, Issue:2

    Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Fluorescence; Laparoscopy; Neoplasm Staging; Peritoneal Neoplasms; Photosensitizing Agents; Protoporphyrins; Random Allocation; Rats; Rats, Inbred Strains; Tumor Cells, Cultured

2002
Isolation and characterization of a cDNA from soybean and its homolog from Escherichia coli, which both complement the light sensitivity of Escherichia coli hemH mutant strain VS101.
    Genes & genetic systems, 2001, Volume: 76, Issue:5

    Topics: Aminolevulinic Acid; Bacteriophages; DNA, Bacterial; DNA, Complementary; Escherichia coli; Ferrochelatase; Gene Deletion; Genetic Complementation Test; Glycine max; Heme; Light; Lysogeny; Mutation; Open Reading Frames; Protoporphyrins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transformation, Genetic

2001
PpIX fluorescence kinetics and increased skin damage after intracutaneous injection of 5-aminolevulinic acid and repeated illumination.
    The Journal of investigative dermatology, 2002, Volume: 118, Issue:2

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Radiation; Female; Fluorescence; Injections, Intradermal; Kinetics; Light; Osmolar Concentration; Photosensitizing Agents; Protoporphyrins; Retreatment; Skin; Skin Temperature; Swine; Tissue Distribution; Wound Healing

2002
Potential efficacy of a delta 5-aminolevulinic acid thermosetting gel formulation for use in photodynamic therapy of lesions of the gastrointestinal tract.
    Pharmacological research, 2002, Volume: 45, Issue:2

    Topics: Aminolevulinic Acid; Animals; Barrett Esophagus; Drug Stability; Gastric Mucosa; Gels; Male; Mice; Mice, Inbred Strains; Photochemotherapy; Photosensitizing Agents; Poloxamer; Prodrugs; Protoporphyrins; Spectrometry, Fluorescence; Temperature; Time Factors

2002
Oxygen-mediated regulation of porphobilinogen formation in Rhodobacter capsulatus.
    Journal of bacteriology, 2002, Volume: 184, Issue:6

    Topics: Aminolevulinic Acid; Bacterial Proteins; Bacteriochlorophylls; Escherichia coli Proteins; Genes, Bacterial; Hemin; Hydroxymethylbilane Synthase; Mixed Function Oxygenases; Molecular Sequence Data; Mutation; Oxygen; Porphobilinogen; Porphobilinogen Synthase; Protoporphyrins; Rhodobacter capsulatus; Transcription, Genetic

2002
Systemic component of protoporphyrin IX production in nude mouse skin upon topical application of aminolevulinic acid depends on the application conditions.
    Photochemistry and photobiology, 2002, Volume: 75, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Mice; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Skin

2002
The fluorescence biodistribution and kinetics of aminolevulinic acid induced protoporphyrin IX in the bladder of a rat model with orthotopic urothelial carcinoma.
    The Journal of urology, 2002, Volume: 167, Issue:4

    Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Carcinoma, Transitional Cell; Female; Fluorescence; Injections, Intravenous; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Tissue Distribution; Urinary Bladder Neoplasms

2002
Aminolaevulinic acid-induced photodynamic therapy: cellular responses to glucose starvation.
    British journal of cancer, 2002, Apr-22, Volume: 86, Issue:8

    Topics: Aminolevulinic Acid; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Glucose; Humans; Light; Phototherapy; Protoporphyrins; Tumor Cells, Cultured

2002
Localization and staging of cervical intraepithelial neoplasia using double ratio fluorescence imaging.
    Journal of biomedical optics, 2002, Volume: 7, Issue:2

    Topics: Adult; Aminolevulinic Acid; Colposcopy; Female; Humans; Middle Aged; Monte Carlo Method; Neoplasm Staging; Optics and Photonics; Protoporphyrins; Spectrometry, Fluorescence; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms

2002
PDT effects of m-THPC and ALA, phototoxicity and apoptosis.
    Apoptosis : an international journal on programmed cell death, 2002, Volume: 7, Issue:3

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Survival; DNA Fragmentation; Light; Mesoporphyrins; Mice; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Tumor Cells, Cultured

2002
In vitro/in vivo correlations between transdermal delivery of 5-aminolaevulinic acid and cutaneous protoporphyrin IX accumulation and effect of formulation.
    The British journal of dermatology, 2002, Volume: 146, Issue:5

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Administration Schedule; Epidermis; Female; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin; Skin Absorption

2002
Quantitative model calculation of the time-dependent protoporphyrin IX concentration in normal human epidermis after delivery of ALA by passive topical application or lontophoresis.
    Photochemistry and photobiology, 2002, Volume: 75, Issue:4

    Topics: Administration, Topical; Aminolevulinic Acid; Epidermis; Humans; Iontophoresis; Models, Biological; Protoporphyrins

2002
Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester.
    Journal of photochemistry and photobiology. B, Biology, 2002, Volume: 67, Issue:1

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Fluorescence; Kinetics; Mice; Mice, Hairless; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Ultraviolet Rays

2002
Photodynamic therapy of human Barrett's cancer using 5-aminolaevulinic acid-induced protoporphyrin IX: an in-vivo dosimetry study in athymic nude mice.
    European journal of gastroenterology & hepatology, 2002, Volume: 14, Issue:6

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Barrett Esophagus; Esophageal Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiometry

2002
Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo.
    British journal of cancer, 2002, Jul-15, Volume: 87, Issue:2

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Antineoplastic Agents; Carboxylesterase; Carboxylic Ester Hydrolases; Carcinoma; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Esters; Female; Injections, Intravenous; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Porphyrins; Prodrugs; Protoporphyrins; Tumor Cells, Cultured

2002
Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice.
    Archives of dermatological research, 2002, Volume: 294, Issue:5

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Drug Administration Schedule; Mice; Mice, Hairless; Microscopy, Fluorescence; Neoplasms, Radiation-Induced; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Time Factors; Ultraviolet Rays

2002
In vivo pharmacokinetics of 8-aminolevulinic acid-induced protoporphyrin IX during pre- and post-photodynamic therapy in 7,12-dimethylbenz(a)nthracene-treated skin carcinogenesis in Swiss mice: a comparison by three-compartment model.
    Photochemistry and photobiology, 2002, Volume: 76, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Female; Mice; Models, Biological; Photochemotherapy; Protoporphyrins; Skin Neoplasms

2002
Comparison of 5-aminolevulinic acid and its hexylester mediated photodynamic action on human hepatoma cells.
    Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 2002, Volume: 34, Issue:5

    Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2002
[5-Aminolevulinic acid esters based photodynamic therapy].
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2002, Volume: 19, Issue:2

    Topics: Aminolevulinic Acid; Esters; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins

2002
Kinetics of 5-aminolevulinic acid-induced fluorescence in organ cultures of bronchial epithelium and tumor.
    Respiration; international review of thoracic diseases, 2002, Volume: 69, Issue:5

    Topics: Aminolevulinic Acid; Analysis of Variance; Bronchi; Bronchial Neoplasms; Carcinoma, Non-Small-Cell Lung; Coculture Techniques; Epithelial Cells; Fluorescence; Humans; Kinetics; Lung Neoplasms; Microscopy, Fluorescence; Organ Culture Techniques; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrum Analysis

2002
Detection of neoplasms in the oral cavity by digitized endoscopic imaging of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
    International journal of oncology, 2002, Volume: 21, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aminolevulinic Acid; Endoscopy; Female; Fluorescent Dyes; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Mouth Neoplasms; Photosensitizing Agents; Protoporphyrins; Software

2002
Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice.
    Biochemical and biophysical research communications, 2002, Sep-27, Volume: 297, Issue:3

    Topics: Administration, Topical; Alamethicin; Aminolevulinic Acid; Animals; Cell Division; Hutchinson's Melanotic Freckle; Melanoma, Experimental; Mice; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Tumor Cells, Cultured

2002
Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
    Gastrointestinal endoscopy, 2002, Volume: 56, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagoscopy; Esophagus; Humans; Lasers; Male; Middle Aged; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence

2002
Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model.
    Photochemistry and photobiology, 2002, Volume: 76, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Esters; Female; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Protoporphyrins; Skin

2002
Temperature effect on accumulation of protoporphyrin IX after topical application of 5-aminolevulinic acid and its methylester and hexylester derivatives in normal mouse skin.
    Photochemistry and photobiology, 2002, Volume: 76, Issue:4

    Topics: Administration, Topical; Aminolevulinic Acid; Anesthesia; Animals; Esters; Mice; Protoporphyrins; Skin; Spectrometry, Fluorescence; Temperature

2002
Comparison of normal piglet bladder damage after PDT with oral or intravesical administration of ALA.
    Lasers in medical science, 2002, Volume: 17, Issue:4

    Topics: Administration, Intravesical; Administration, Oral; Aminolevulinic Acid; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Swine; Tissue Distribution; Urinary Bladder

2002
Hyperresistance to photosensitized lipid peroxidation and apoptotic killing in 5-aminolevulinate-treated tumor cells overexpressing mitochondrial GPX4.
    Free radical biology & medicine, 2002, Nov-15, Volume: 33, Issue:10

    Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Survival; Flow Cytometry; Free Radicals; Glutathione Peroxidase; Humans; Lipid Peroxidation; Lipid Peroxides; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Phospholipid Hydroperoxide Glutathione Peroxidase; Phospholipids; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Rhodamine 123; Subcellular Fractions; Time Factors; Transfection; Tumor Cells, Cultured

2002
Gene expression pattern following photodynamic treatment of the carcinoma cell line A-431 analysed by cDNA arrays.
    International journal of oncology, 2002, Volume: 21, Issue:6

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Survival; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, jun; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Humans; Membrane Proteins; Necrosis; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-fos; Protoporphyrins; RNA, Messenger; Subcellular Fractions; Tumor Cells, Cultured

2002
Differentiation enhances aminolevulinic acid-dependent photodynamic treatment of LNCaP prostate cancer cells.
    British journal of cancer, 2002, Nov-18, Volume: 87, Issue:11

    Topics: Aminolevulinic Acid; Cell Differentiation; Flow Cytometry; Humans; Male; Metribolone; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Testosterone Congeners; Tretinoin; Tumor Cells, Cultured; Vitamin D

2002
Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters.
    International journal of cancer, 2003, Jan-01, Volume: 103, Issue:1

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Esters; Female; Mice; Mice, Inbred BALB C; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence; Tissue Distribution

2003
[Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid].
    Laryngo- rhino- otologie, 2002, Volume: 81, Issue:11

    Topics: Administration, Inhalation; Administration, Oral; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Humans; Laryngeal Neoplasms; Mouth Mucosa; Mouth Neoplasms; Neoplasm Staging; Oropharyngeal Neoplasms; Precancerous Conditions; Prognosis; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence

2002
Metabolic characterization of tumor cell-specific protoporphyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells.
    Photochemistry and photobiology, 2002, Volume: 76, Issue:5

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Fibroblasts; Humans; Iron; Light; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Receptors, Transferrin; Spectrometry, Fluorescence

2002
Transfer of protoporphyrin IX between cells.
    Photochemistry and photobiology, 2002, Volume: 76, Issue:5

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Communication; Cell Line, Tumor; Colonic Neoplasms; Humans; Jurkat Cells; Leukemia; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; T-Lymphocytes; Time Factors

2002
Time gated fluorescence spectroscopy in Barrett's oesophagus.
    Gut, 2003, Volume: 52, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Biomarkers, Tumor; Biopsy; Diagnosis, Differential; Esophageal Neoplasms; Esophagus; Female; Humans; Intestines; Male; Metaplasia; Middle Aged; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Signal Processing, Computer-Assisted; Spectrometry, Fluorescence; Tumor Suppressor Protein p53

2003
A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder cancer.
    International journal of oncology, 2003, Volume: 22, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biological Transport, Active; Carcinoma; Cystoscopy; Ferrochelatase; Humans; Hydroxymethylbilane Synthase; Image Processing, Computer-Assisted; Injections, Intravenous; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Transplantation, Heterologous; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2003
Fluorescence confocal microscopy and image analysis of bladder cancer using 5-aminolevulinic acid.
    International journal of oncology, 2003, Volume: 22, Issue:3

    Topics: Administration, Intravesical; Aminolevulinic Acid; Biomarkers, Tumor; Carcinoma in Situ; Carcinoma, Transitional Cell; Humans; Image Processing, Computer-Assisted; Light; Microscopy, Confocal; Microscopy, Fluorescence; Mucous Membrane; Muscle, Smooth; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms; Urothelium

2003
Phototoxic effects of 635-nm light on canine transitional cell carcinoma cells incubated with 5-aminolevulinic acid.
    American journal of veterinary research, 2003, Volume: 64, Issue:2

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Transitional Cell; Cell Survival; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Lasers; Light; Photochemotherapy; Protoporphyrins; Time Factors; Tumor Cells, Cultured

2003
Acceleration of ALA-induced PpIX fluorescence development in the oral mucosa.
    Lasers in surgery and medicine, 2003, Volume: 32, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Analysis of Variance; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Mouth Mucosa; Mouth Neoplasms; Photosensitizing Agents; Probability; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence

2003
Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for photosensitizers in photodynamic therapy.
    Bioorganic & medicinal chemistry, 2003, Apr-03, Volume: 11, Issue:7

    Topics: Aminolevulinic Acid; Cells, Cultured; Dipeptides; Endothelium, Vascular; Humans; Hydrolysis; Neprilysin; Peptide Hydrolases; Peptides; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured

2003
In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2002, Volume: 1, Issue:5

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Kinetics; Lasers; Microscopy, Fluorescence; Nasopharyngeal Neoplasms; Necrosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2002
Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2002, Volume: 1, Issue:10

    Topics: Aminolevulinic Acid; Animals; Female; Humans; Light; Models, Biological; Models, Chemical; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Nude; Skin; Spectrometry, Fluorescence; Tissue Distribution; Tumor Cells, Cultured

2002
Dose and timing of the first light fraction in two-fold illumination schemes for topical ALA-mediated photodynamic therapy of hairless mouse skin.
    Photochemistry and photobiology, 2003, Volume: 77, Issue:3

    Topics: Aminolevulinic Acid; Animals; Female; Kinetics; Mice; Mice, Hairless; Necrosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2003
Two course illuminating scheme improves aminolevulinic acid photodynamic therapy in cell cultures.
    Cellular and molecular biology (Noisy-le-Grand, France), 2002, Volume: 48, Issue:8

    Topics: Aminolevulinic Acid; Barrett Esophagus; Cell Line, Transformed; Cells, Cultured; Ferrochelatase; Humans; Hydroxymethylbilane Synthase; Light; Photochemotherapy; Porphyrins; Protoporphyrins; Time Factors

2002
Production of protoporphyrin IX from 5-aminolevulinic acid and two of its esters in cells in vitro and tissues in vivo.
    Cellular and molecular biology (Noisy-le-Grand, France), 2002, Volume: 48, Issue:8

    Topics: Aminolevulinic Acid; Animals; Cell Survival; Dose-Response Relationship, Drug; Female; Kinetics; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Protein Binding; Protoporphyrins; Spectrometry, Fluorescence; Time Factors

2002
Improving the use of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PPIX) for the gastrointestinal tract by esterification--an in vitro study.
    Cellular and molecular biology (Noisy-le-Grand, France), 2002, Volume: 48, Issue:8

    Topics: Aminolevulinic Acid; Cell Line; Colon; Digestive System; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Flow Cytometry; Humans; Kinetics; Light; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence; Time Factors; Tumor Cells, Cultured

2002
Photodynamic diagnosis of ovarian cancer using hexaminolaevulinate: a preclinical study.
    British journal of cancer, 2003, Jun-02, Volume: 88, Issue:11

    Topics: Aminolevulinic Acid; Animals; Diagnostic Techniques and Procedures; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelium; Feasibility Studies; Female; Fluorescence; Neoplasm Staging; Ovarian Neoplasms; Peritoneal Neoplasms; Photosensitizing Agents; Prognosis; Protoporphyrins; Rats; Rats, Inbred F344; Sensitivity and Specificity

2003
Fluorescence endoscopy for the detection of low and high grade dysplasia in ulcerative colitis using systemic or local 5-aminolaevulinic acid sensitisation.
    Gut, 2003, Volume: 52, Issue:7

    Topics: Adult; Aged; Aminolevulinic Acid; Biopsy; Colitis, Ulcerative; Endoscopy, Gastrointestinal; Feasibility Studies; Female; Fluorescence; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity

2003
Photodynamic effects of 5-aminolevulinic acid and its hexylester on several cell lines.
    Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 2003, Volume: 35, Issue:7

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Mitochondria; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2003
Selective accumulation of ALA-induced PpIX and photodynamic effect in chemically induced hepatocellular carcinoma.
    British journal of cancer, 2003, Aug-18, Volume: 89, Issue:4

    Topics: Alkylating Agents; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Lasers; Liver; Liver Neoplasms, Experimental; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Spectrometry, Fluorescence

2003
Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid.
    Endoscopy, 2003, Volume: 35, Issue:8

    Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Carcinoma in Situ; Esophageal Neoplasms; Esophagoscopy; Female; Fluorescence; Humans; Male; Middle Aged; Photosensitizing Agents; Predictive Value of Tests; Protoporphyrins; Radiography; Reproducibility of Results

2003
Aminolaevulinic acid-induced protoporphyrin IX pharmacokinetics in central and peripheral arteries of the rat.
    Photochemistry and photobiology, 2003, Volume: 78, Issue:1

    Topics: Aminolevulinic Acid; Animals; Arteries; Male; Mitochondria; Porphobilinogen; Protoporphyrins; Rats; Rats, Wistar; Time Factors

2003
ALA (5-aminolevulinic acid)-induced protoporphyrin IX fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2004, Volume: 261, Issue:5

    Topics: Adult; Aged; Aminolevulinic Acid; Diagnosis, Differential; Female; Fluorescence; Humans; Laryngeal Neoplasms; Laryngoscopy; Laser Therapy; Male; Middle Aged; Neoplasm Staging; Pharyngeal Neoplasms; Photosensitizing Agents; Precancerous Conditions; Prospective Studies; Protoporphyrins; Risk Assessment; Sensitivity and Specificity; Treatment Outcome

2004
[Effects of inosine on the urinary elimination of coproporphyrin and delta-aminolevulinic acid and on the behavior of erythrocytic protoporphyrin IX].
    Folia medica. Folia medica (Naples, Italy), 1962, Volume: 45

    Topics: Aminolevulinic Acid; Coproporphyrins; Erythrocytes; Humans; Inosine; Levulinic Acids; Nucleosides; Porphyrins; Protoporphyrins

1962
Monitoring in situ dosimetry and protoporphyrin IX fluorescence photobleaching in the normal rat esophagus during 5-aminolevulinic acid photodynamic therapy.
    Photochemistry and photobiology, 2003, Volume: 78, Issue:3

    Topics: Aminolevulinic Acid; Animals; Male; Photochemotherapy; Protoporphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence

2003
Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester.
    Cancer letters, 2003, Oct-28, Volume: 200, Issue:2

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line; Cerebellum; Glioma; Humans; Neuroblastoma; Photosensitizing Agents; Protoporphyrins; Rats; Tumor Cells, Cultured

2003
In vivo fluorescence kinetics and photodynamic therapy in condylomata acuminata.
    The British journal of dermatology, 2003, Volume: 149, Issue:5

    Topics: Adult; Aminolevulinic Acid; Condylomata Acuminata; Fluorescence; Humans; Male; Penile Diseases; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors; Treatment Outcome

2003
In vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapy.
    Cancer research, 2003, Nov-15, Volume: 63, Issue:22

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Humans; Leukemia, Monocytic, Acute; Luminescent Measurements; Photochemotherapy; Protoporphyrins; Reproducibility of Results; Singlet Oxygen; Spectrum Analysis

2003
Protoporphyrin IX-accumulation in human tumor cells following topical ALA- and h-ALA-application in vivo.
    Cancer letters, 2003, Dec-08, Volume: 202, Issue:1

    Topics: Administration, Topical; Allantois; Aminolevulinic Acid; Animals; Chick Embryo; Female; Humans; Laryngeal Neoplasms; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured

2003
Fluorescence microspectroscopy technique for the study of intracellular protoporphyrin IX dynamics.
    Applied spectroscopy, 2003, Volume: 57, Issue:6

    Topics: Aminolevulinic Acid; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Fibroblasts; Humans; Intracellular Space; Keratinocytes; Microspectrophotometry; Photoperiod; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

2003
Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratum.
    Biochimica et biophysica acta, 2004, Jan-05, Volume: 1670, Issue:1

    Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Cell Survival; Fluorescent Dyes; Glioblastoma; Humans; Microscopy, Fluorescence; Organic Chemicals; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Rotenone; Spectrometry, Fluorescence; Trypsin; Trypsin Inhibitors

2004
Effect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpIX production in human skin.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2004, Volume: 3, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Hot Temperature; Humans; In Vitro Techniques; Kinetics; Male; Mice; Mice, Hairless; Photochemotherapy; Protoporphyrins; Skin; Skin Temperature

2004
The use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo.
    International journal of cancer, 2004, Jun-10, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Diagnostic Imaging; Endoscopy; Female; Fluorescence; Humans; Male; Middle Aged; Mouth Neoplasms; Precancerous Conditions; Protoporphyrins; Sensitivity and Specificity

2004
Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - in vivo experiments on the dunning rat tumor model.
    Urologia internationalis, 2004, Volume: 72, Issue:3

    Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Male; Photochemotherapy; Prostatic Neoplasms; Protoporphyrins; Rats

2004
Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma.
    British journal of cancer, 2004, May-04, Volume: 90, Issue:9

    Topics: Acetamides; Aminolevulinic Acid; Animals; Antineoplastic Agents; Blotting, Western; Butyrates; Cell Differentiation; Cell Line, Tumor; Flow Cytometry; Hydroxymethylbilane Synthase; Immunohistochemistry; Melanoma, Experimental; Mice; Microscopy, Electron; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2004
Influence of CaNa2 EDTA on topical 5-aminolaevulinic acid photodynamic therapy.
    Chinese medical journal, 2004, Volume: 117, Issue:6

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Edetic Acid; Female; Humans; Male; Middle Aged; Photochemotherapy; Protoporphyrins; Skin Neoplasms

2004
Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy.
    International journal of oncology, 2004, Volume: 25, Issue:1

    Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Microscopy, Fluorescence; Protoporphyrins; Rabbits; Reference Values

2004
In vitro evaluation of the cytotoxic and mutagenic potential of the 5-aminolevulinic acid hexylester-mediated photodynamic therapy.
    Mutation research, 2004, Jul-11, Volume: 561, Issue:1-2

    Topics: Aminolevulinic Acid; Chromosome Aberrations; Humans; Light; Micronuclei, Chromosome-Defective; Mitotic Index; Mutagenicity Tests; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectral Karyotyping; Tumor Cells, Cultured

2004
delta-Aminolaevulinic acid mediated photodynamic antimicrobial chemotherapy on Pseudomonas aeruginosa planktonic and biofilm cultures.
    Journal of photochemistry and photobiology. B, Biology, 2004, Jul-19, Volume: 75, Issue:1-2

    Topics: Aminolevulinic Acid; Biofilms; Light; Photochemotherapy; Photosensitizing Agents; Plankton; Prodrugs; Protoporphyrins; Pseudomonas aeruginosa

2004
Effect of 5-aminolevulinic acid on kinetics of protoporphyrin IX production in CHO cells.
    Folia histochemica et cytobiologica, 2004, Volume: 42, Issue:2

    Topics: Aminolevulinic Acid; Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Female; Kinetics; Ovary; Protoporphyrins

2004
Confocal endomicroscopic imaging of normal and neoplastic human tongue tissue using ALA-induced-PPIX fluorescence: a preliminary study.
    Oncology reports, 2004, Volume: 12, Issue:2

    Topics: Aminolevulinic Acid; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Time Factors; Tongue; Tongue Neoplasms

2004
5-aminolevulinic acid-based photodynamic therapy in leukemia cell HL60.
    Photochemistry and photobiology, 2004, Volume: 79, Issue:6

    Topics: Aminolevulinic Acid; Annexins; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescence; HL-60 Cells; Humans; Leukemia, Experimental; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Time Factors

2004
Hexaminolevulinate-induced fluorescence endoscopy in patients with rectal adenoma and cancer: a pilot study.
    Gastrointestinal endoscopy, 2004, Volume: 60, Issue:3

    Topics: Adenoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Cell Transformation, Neoplastic; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Dose-Response Relationship, Drug; Feasibility Studies; Female; Fluorescent Dyes; Humans; Intestinal Mucosa; Male; Microscopy, Fluorescence; Middle Aged; Precancerous Conditions; Proctoscopy; Protoporphyrins

2004
5-aminolevulinic acid ester-induced protoporphyrin IX in a murine melanoma cell line.
    Lasers in medical science, 2004, Volume: 19, Issue:2

    Topics: Aminolevulinic Acid; Animals; Diffusion; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Melanoma; Mice; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2004
Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase.
    Protein expression and purification, 2004, Volume: 37, Issue:2

    Topics: Aminolevulinic Acid; Biochemistry; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Histidine; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Iron; Isopropyl Thiogalactoside; Kynurenine; Plasmids; Protoporphyrins; Recombinant Proteins; Temperature; Time Factors; Tryptophan; Tryptophan Oxygenase

2004
Phototoxicity of exogenous protoporphyrin IX and delta-aminolevulinic acid in the photo hen's egg test.
    Photodermatology, photoimmunology & photomedicine, 2004, Volume: 20, Issue:5

    Topics: Aminolevulinic Acid; Animals; Chick Embryo; Dermatitis, Phototoxic; Disease Models, Animal; Forecasting; Hemorrhage; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation Dosage; Risk Assessment; Survival Rate; Time Factors; Ultraviolet Rays; Yolk Sac

2004
Increased brain tumor resection using fluorescence image guidance in a preclinical model.
    Lasers in surgery and medicine, 2004, Volume: 35, Issue:3

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Microscopy; Models, Animal; Neoplasm, Residual; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Rabbits; Spectrometry, Fluorescence

2004
Time-dependent hexaminolaevulinate induced protoporphyrin IX distribution after topical application in patients with cervical intraepithelial neoplasia: A fluorescence microscopy study.
    Lasers in surgery and medicine, 2004, Volume: 35, Issue:4

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Female; Humans; Microscopy, Fluorescence; Middle Aged; Photosensitizing Agents; Protoporphyrins; Time Factors; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms

2004
Phototoxicity of 5-aminolevulinic acid in the HeLa cell line as an indicative measure of photodynamic effect after topical administration to gynecological lesions of intraepithelial form.
    Pharmaceutical research, 2004, Volume: 21, Issue:10

    Topics: Aminolevulinic Acid; Cell Death; Cell Survival; Dermatitis, Phototoxic; Diffusion Chambers, Culture; Epithelium; Female; Genital Diseases, Female; HeLa Cells; Humans; In Vitro Techniques; Isotope Labeling; Light; Photochemotherapy; Proteins; Protoporphyrins; Tissue Adhesives; Vagina

2004
Effect of 5-aminolevulinic acid (ALA) doses and oestrogen/progesterone on protoporphyrin IX (ppIX) accumulation in human endometrial epithelial cells.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 2004, Volume: 49 Suppl 1

    Topics: Aminolevulinic Acid; Endometrium; Epithelial Cells; Estradiol; Female; Humans; Progesterone; Protoporphyrins

2004
In vitro metabolism of 5-ALA esters derivatives in hairless mice skin homogenate and in vivo PpIX accumulation studies.
    Pharmaceutical research, 2004, Volume: 21, Issue:12

    Topics: Aminolevulinic Acid; Animals; Esters; Male; Mice; Mice, Hairless; Photosensitizing Agents; Protoporphyrins; Skin

2004
Effect of oil-in-water emulsions on 5-aminolevulinic acid uptake and metabolism to PpIX in cultured MCF-7 cells.
    Pharmaceutical research, 2004, Volume: 21, Issue:12

    Topics: Aminolevulinic Acid; Emulsions; Endocytosis; Humans; Oils; Protoporphyrins; Tumor Cells, Cultured; Water

2004
Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling.
    Biophysical journal, 2005, Volume: 88, Issue:4

    Topics: Aminolevulinic Acid; Animals; Biophysics; Cell Line, Tumor; Culture Techniques; Light; Liver; Mice; Microscopy, Electron; Microscopy, Polarization; Mitochondria; Mitochondrial Swelling; Models, Statistical; Oxidative Stress; Oxygen Consumption; Protoporphyrins; Rabbits; Scattering, Radiation; Time Factors

2005
ABCG2-mediated transport of photosensitizers: potential impact on photodynamic therapy.
    Cancer biology & therapy, 2005, Volume: 4, Issue:2

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Proliferation; Chlorophyll; Chlorophyllides; Flow Cytometry; Fluorescence; Humans; Indoles; Kidney; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Tumor Cells, Cultured

2005
Specific intensity imaging for glioblastoma and neural cell cultures with 5-aminolevulinic acid-derived protoporphyrin IX.
    Journal of neuro-oncology, 2005, Volume: 71, Issue:2

    Topics: Aminolevulinic Acid; Animals; Astrocytes; Cells, Cultured; Fluorescence; Glioblastoma; Humans; Neurons; Photosensitizing Agents; Protoporphyrins; Rats; Time Factors

2005
The monitoring of the accumulation of protoporphyrin IX in Walker tumours by subcutaneous administration of delta-aminolevulinic acid.
    Journal of experimental therapeutics & oncology, 2004, Volume: 4, Issue:3

    Topics: Aminolevulinic Acid; Animals; Carcinoma 256, Walker; Injections, Subcutaneous; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Skin Neoplasms

2004
Antifungal effect of 5-aminolevulinic acid PDT in Trichophyton rubrum.
    Mycoses, 2005, Volume: 48, Issue:2

    Topics: Aminolevulinic Acid; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Mycelium; Onychomycosis; Photochemotherapy; Protoporphyrins; Trichophyton

2005
Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2005, Volume: 4, Issue:4

    Topics: alpha-Tocopherol; Aminolevulinic Acid; Arachidonic Acid; Cell Line, Tumor; Cell Proliferation; Cell Survival; Docosahexaenoic Acids; Fatty Acids, Unsaturated; Humans; Malondialdehyde; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2005
RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid-induced protoporphyrin IX in vitro.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:4

    Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspases; Catalysis; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Membrane; Cluster Analysis; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genetic Techniques; Humans; Immediate-Early Proteins; In Vitro Techniques; Mitochondria; Models, Genetic; Models, Statistical; Necrosis; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phosphoprotein Phosphatases; Photochemotherapy; Photosensitizing Agents; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors; Up-Regulation

2005
Reorganization of cytoskeleton induced by 5-aminolevulinic acid-mediated photodynamic therapy and its correlation with mitochondrial dysfunction.
    Lasers in surgery and medicine, 2005, Volume: 36, Issue:5

    Topics: Acid Phosphatase; Adenosine Triphosphate; Aminolevulinic Acid; Animals; Cell Adhesion; Cytoskeleton; Membrane Potentials; Mice; Microscopy, Electron, Transmission; Microscopy, Video; Mitochondria; NIH 3T3 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2005
Enhancement of the effect of 5-aminolevulinic acid-based photodynamic therapy by simultaneous hyperthermia.
    International journal of oncology, 2005, Volume: 27, Issue:1

    Topics: Aminolevulinic Acid; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Separation; Chaperonin 60; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; HSP70 Heat-Shock Proteins; Humans; Hyperthermia, Induced; Light; Membrane Potentials; Microscopy, Phase-Contrast; Mitochondria; Osteosarcoma; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors

2005
Lipid cubic phases for improved topical drug delivery in photodynamic therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2005, Sep-02, Volume: 106, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Fluorescence; Glycerides; Lipids; Mice; Mice, Inbred BALB C; Photochemotherapy; Protoporphyrins

2005
Topical glycerol monooleate/propylene glycol formulations enhance 5-aminolevulinic acid in vitro skin delivery and in vivo protophorphyrin IX accumulation in hairless mouse skin.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2005, Volume: 60, Issue:3

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Chemistry, Pharmaceutical; Glycerides; In Vitro Techniques; Male; Mice; Mice, Hairless; Propylene Glycol; Protoporphyrins; Rats; Skin; Skin Absorption

2005
Determination of intracellular prolyl/glycyl proteases in intact living human cells and protoporphyrin IX production as a reporter system.
    Chemistry & biology, 2005, Volume: 12, Issue:8

    Topics: Adenosine Deaminase; Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cysteine Endopeptidases; Dipeptidyl Peptidase 4; Drug Design; Female; Fluorescent Dyes; Glycoproteins; Humans; Kinetics; Male; Methods; Prolyl Oligopeptidases; Protease Inhibitors; Protoporphyrins; Serine Endopeptidases; Substrate Specificity

2005
In vitro and ex vivo protoporphyrin IX expression induced by 5-aminolevulinic acid in human pilosebaceous unit.
    Journal of dermatological science, 2005, Volume: 40, Issue:1

    Topics: Aminolevulinic Acid; Hair Follicle; Humans; Keratinocytes; Protoporphyrins; Sebaceous Glands

2005
Photodynamic therapy of Walker tumors by multiple laser irradiation.
    Photomedicine and laser surgery, 2005, Volume: 23, Issue:4

    Topics: Aminolevulinic Acid; Animals; Carcinoma 256, Walker; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats

2005
Correlation between macroscopic fluorescence and protoporphyrin IX content in psoriasis and actinic keratosis following application of aminolevulinic acid.
    The Journal of investigative dermatology, 2005, Volume: 125, Issue:4

    Topics: Aminolevulinic Acid; DNA; Humans; Keratosis; Protoporphyrins; Psoriasis; Spectrometry, Fluorescence

2005
Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.
    Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:10

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hyperoxia; Lipid Peroxidation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Urinary Bladder Neoplasms

2005
Size and surface charge effect of 5-aminolevulinic acid-containing liposomes on photodynamic therapy for cultivated cancer cells.
    Drug development and industrial pharmacy, 2005, Volume: 31, Issue:7

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Liposomes; Mice; Particle Size; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Surface Properties

2005
Expression pattern and intensity of protoporphyrin IX induced by liposomal 5-aminolevulinic acid in rat pilosebaceous unit throughout hair cycle.
    Archives of dermatological research, 2005, Volume: 297, Issue:5

    Topics: Aminolevulinic Acid; Animals; Hair Follicle; Hydrogen-Ion Concentration; Liposomes; Photochemotherapy; Protoporphyrins; Rats; Rats, Sprague-Dawley; Sebaceous Glands

2005
Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation.
    British journal of cancer, 2005, Nov-14, Volume: 93, Issue:10

    Topics: Aminolevulinic Acid; Animals; Breast Neoplasms; Mice; Mice, Transgenic; Neoplasm Metastasis; Protoporphyrins; Time Factors

2005
Influence of light exposure on the kinetics of protoporphyrin IX formation in normal skin of hairless mice after application of 5-aminolevulinic acid methyl ester.
    The Journal of investigative dermatology, 2005, Volume: 125, Issue:5

    Topics: Aminolevulinic Acid; Animals; Kinetics; Light; Mice; Mice, Hairless; Protoporphyrins; Skin

2005
Targeting PBR by hexaminolevulinate-mediated photodynamic therapy induces apoptosis through translocation of apoptosis-inducing factor in human leukemia cells.
    Cancer research, 2005, Dec-01, Volume: 65, Issue:23

    Topics: Aminolevulinic Acid; Apoptosis; Apoptosis Inducing Factor; Cell Line, Tumor; Cell Nucleus; Cytochromes c; Humans; Intracellular Membranes; Leukemia, Lymphoid; Membrane Potentials; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Receptors, GABA; Subcellular Fractions

2005
Photobleaching kinetics, photoproduct formation, and dose estimation during ALA induced PpIX PDT of MLL cells under well oxygenated and hypoxic conditions.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2006, Volume: 5, Issue:1

    Topics: Aminolevulinic Acid; Animals; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Light; Oxygen; Photobleaching; Photosensitizing Agents; Protoporphyrins; Rats; Sensitivity and Specificity; Spectrometry, Fluorescence

2006
The cytotoxic and genotoxic potential of 5-aminolevulinic acid on lymphocytes: a comet assay study.
    Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:3

    Topics: Aged; Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; Humans; Lymphocytes; Male; Microscopy, Confocal; Mutagens; Nasopharyngeal Neoplasms; Photosensitizing Agents; Protoporphyrins; Ultraviolet Rays

2006
In vitro percutaneous absorption and in vivo protoporphyrin IX accumulation in skin and tumors after topical 5-aminolevulinic acid application with enhancement using an erbium:YAG laser.
    Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:4

    Topics: Administration, Cutaneous; Aluminum; Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Cell Line, Tumor; Erbium; Female; In Vitro Techniques; Lasers; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Absorption; Skin Neoplasms; Water Loss, Insensible; Yttrium

2006
Regulation of porphyrin synthesis and photodynamic therapy in heavy metal intoxication.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Cell Cycle; Enzyme Inhibitors; Gallium; Humans; Hydroxymethylbilane Synthase; Lead; Neurons; PC12 Cells; Photochemotherapy; Photosensitizing Agents; Porphobilinogen Synthase; Proteasome Endopeptidase Complex; Protoporphyrins; Rats; RNA, Messenger

2006
Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cytochromes c; DNA Fragmentation; Humans; Membrane Potentials; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2006
Spectroscopic measurements of photoinduced processes in human skin after topical application of the hexyl ester of 5-aminolevulinic acid.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2006, Volume: 25, Issue:1-2

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Humans; Male; Oxyhemoglobins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Spectrum Analysis

2006
Characteristics of 5-aminolaevulinic acid-induced protoporphyrin IX fluorescence in human skin in vivo.
    Photodermatology, photoimmunology & photomedicine, 2006, Volume: 22, Issue:2

    Topics: Adult; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Middle Aged; Protoporphyrins; Reference Values; Skin

2006
Fluorescence staining of human ovarian cancer tissue following application of 5-aminolevulinic acid: fluorescence microscopy studies.
    Lasers in surgery and medicine, 2006, Volume: 38, Issue:5

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Biopsy; Fallopian Tube Neoplasms; Female; Humans; Laparoscopy; Microscopy, Fluorescence; Ovarian Neoplasms; Photochemotherapy; Photosensitizing Agents; Predictive Value of Tests; Protoporphyrins; Second-Look Surgery; Sensitivity and Specificity

2006
Integral spectrophotometric analysis of 5-aminolaevulinic acid-induced fluorescence cytology of the urinary bladder.
    BJU international, 2006, Volume: 97, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Female; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Therapeutic Irrigation; Urinary Bladder; Urinary Bladder Neoplasms

2006
In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2006, Volume: 63, Issue:3

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Delivery Systems; Epidermis; Humans; Membranes, Artificial; Ointments; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms

2006
Griseofulvin enhances the effect of aminolevulinic acid-based photodynamic therapy in vitro.
    Photomedicine and laser surgery, 2006, Volume: 24, Issue:2

    Topics: Aminolevulinic Acid; Antifungal Agents; Griseofulvin; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2006
Subcellular localization pattern of protoporphyrin IX is an important determinant for its photodynamic efficiency of human carcinoma and normal cell lines.
    Journal of photochemistry and photobiology. B, Biology, 2006, Sep-01, Volume: 84, Issue:3

    Topics: Adenosine Triphosphate; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Cell Survival; Esophageal Neoplasms; Humans; Membrane Potentials; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Subcellular Fractions

2006
Influence of administration methods on the accumulation of ALA-induced Pp-IX in mouse tongue tumors.
    Oral diseases, 2006, Volume: 12, Issue:4

    Topics: Administration, Oral; Administration, Topical; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Statistics, Nonparametric; Tongue Neoplasms

2006
Tumor cell lines resistant to ALA-mediated photodynamic therapy and possible tools to target surviving cells.
    International journal of oncology, 2006, Volume: 29, Issue:2

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Light; Mice; Oxygen Consumption; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Pyrimidinones; Tetrazolium Salts; Thiazoles

2006
Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells.
    British journal of cancer, 2006, Aug-21, Volume: 95, Issue:4

    Topics: Aminolevulinic Acid; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coproporphyrinogen Oxidase; Humans; Male; Methotrexate; Metribolone; Models, Biological; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Up-Regulation

2006
Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 291, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cattle; Deferoxamine; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heme; Iron; Models, Biological; Organ Culture Techniques; Oxidation-Reduction; Photosensitizing Agents; Protoporphyrins; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Serotonin; Soluble Guanylyl Cyclase; Vasodilation

2006
Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study.
    The British journal of dermatology, 2006, Volume: 155, Issue:3

    Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Biopsy; Cell Differentiation; Cell Proliferation; Epidermis; Female; Filaggrin Proteins; Fluorescence; Humans; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Skin; Skin Absorption; T-Lymphocyte Subsets

2006
Fractionated illumination after topical application of 5-aminolevulinic acid on normal skin of hairless mice: the influence of the dark interval.
    Journal of photochemistry and photobiology. B, Biology, 2006, Dec-01, Volume: 85, Issue:3

    Topics: Aminolevulinic Acid; Animals; Fluorescence; Kinetics; Mice; Mice, Nude; Photobleaching; Photochemotherapy; Photoperiod; Photosensitizing Agents; Protoporphyrins

2006
A study comparing endogenous protoporphyrin IX induced by 5-ALA and ALA-methyl ester with exogenous PpIX and PpIX dimethyl ester in photodynamic diagnosis of human nasopharyngeal carcinoma xenografts.
    International journal of oncology, 2006, Volume: 29, Issue:4

    Topics: Aminolevulinic Acid; Animals; Carcinoma; Humans; Male; Mice; Mice, Inbred Strains; Nasopharyngeal Neoplasms; Photosensitizing Agents; Protoporphyrins; Up-Regulation; Xenograft Model Antitumor Assays

2006
Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin.
    The British journal of dermatology, 2006, Volume: 155, Issue:4

    Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Humans; Middle Aged; Photosensitizing Agents; Protoporphyrins; Skin; Skin Absorption; Spectrometry, Fluorescence

2006
Involvement of both caspase-dependent and -independent pathways in apoptotic induction by hexaminolevulinate-mediated photodynamic therapy in human lymphoma cells.
    Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:11

    Topics: Amino Acid Chloromethyl Ketones; Aminolevulinic Acid; Apoptosis; Apoptosis Inducing Factor; Caspases; Cytochromes c; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia, T-Cell; Membrane Potential, Mitochondrial; Mitochondria; Photochemotherapy; Protoporphyrins

2006
Vitamin D enhances ALA-induced protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytes.
    The Journal of investigative dermatology, 2007, Volume: 127, Issue:4

    Topics: Aminolevulinic Acid; Animals; Biomarkers; Cell Death; Cell Differentiation; Cell Line; Dogs; Keratinocytes; Light; Organ Culture Techniques; Protoporphyrins; Rats; Time Factors; Vitamin D

2007
Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach.
    Lasers in surgery and medicine, 2007, Volume: 39, Issue:1

    Topics: Aminolevulinic Acid; Animals; Cell Survival; In Vitro Techniques; Microscopy, Electron, Scanning; Mucous Membrane; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Soft Tissue Injuries; Spectrometry, Fluorescence; Swine; Urinary Bladder Neoplasms; Urothelium

2007
[5-ALA fluorescence guided tumor resection].
    No to shinkei = Brain and nerve, 2006, Volume: 58, Issue:12

    Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Middle Aged; Mitochondria; Neurosurgical Procedures; Photosensitizing Agents; Prognosis; Protoporphyrins

2006
The role of nitric oxide in delta-aminolevulinic acid (ALA)-induced photosensitivity of cancerous cells.
    Biochemical and biophysical research communications, 2007, Feb-16, Volume: 353, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Ferrochelatase; Humans; Interferon-gamma; Kidney; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Photosensitizing Agents; Protoporphyrins

2007
Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy.
    Journal of neuro-oncology, 2007, Volume: 83, Issue:3

    Topics: Aminolevulinic Acid; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; Flow Cytometry; Glioma; Humans; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction

2007
Relation between intracellular location and photodynamic efficacy of 5-aminolevulinic acid-induced protoporphyrin IX in vitro. Comparison between human glioblastoma cells and other cancer cell lines.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2007, Volume: 6, Issue:2

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Dose-Response Relationship, Radiation; Glioblastoma; Humans; Lasers; Photochemistry; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Structure-Activity Relationship; Tumor Cells, Cultured

2007
Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell.
    Liver international : official journal of the International Association for the Study of the Liver, 2007, Volume: 27, Issue:2

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug Therapy, Combination; Humans; Liver Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tissue Distribution; Treatment Outcome; Tumor Suppressor Protein p53

2007
Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas.
    Neurologia medico-chirurgica, 2007, Volume: 47, Issue:2

    Topics: Aged; Aminolevulinic Acid; Astrocytoma; Brain Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

2007
Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions.
    Journal of photochemistry and photobiology. B, Biology, 2007, May-25, Volume: 87, Issue:2

    Topics: Aminolevulinic Acid; Drug Stability; Esters; Hydrogen-Ion Concentration; Kinetics; Photochemotherapy; Protoporphyrins; Temperature

2007
Photodynamic diagnosis (PDD) using 5-aminolevulinic acid-supplemented cultures of human endometrial epithelial cells.
    Advances in medical sciences, 2006, Volume: 51

    Topics: Aminolevulinic Acid; Cells, Cultured; Endometriosis; Endometrium; Epithelial Cells; Estradiol; Female; Fluorescence; Humans; Microscopy, Confocal; Progesterone; Protoporphyrins; Time Factors

2006
Endoscopic identification and biopsy sampling of an intraventricular malignant glioma using a 5-aminolevulinic acid-induced protoporphyrin IX fluorescence imaging system. Technical note.
    Journal of neurosurgery, 2007, Volume: 106, Issue:3

    Topics: Aminolevulinic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Female; Fluorescence; Humans; Middle Aged; Neuroendoscopy; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted

2007
Detection of urinary bladder cancer with flow cytometry and hexaminolevulinate in urine samples.
    Cytopathology : official journal of the British Society for Clinical Cytology, 2007, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biomarkers, Tumor; Carcinoma, Transitional Cell; Cell Line, Tumor; Cytodiagnosis; Feasibility Studies; Female; Flow Cytometry; Humans; Male; Middle Aged; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity; Urinalysis; Urinary Bladder Neoplasms; Urine; Urothelium

2007
Photodetection of basal cell carcinoma using methyl 5-aminolaevulinate-induced protoporphyrin IX based on fluorescence image analysis.
    Clinical and experimental dermatology, 2007, Volume: 32, Issue:4

    Topics: Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Facial Neoplasms; Female; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence

2007
Two-photon photodynamic therapy of C6 cells by means of 5-aminolevulinic acid induced protoporphyrin IX.
    Journal of photochemistry and photobiology. B, Biology, 2007, Jun-26, Volume: 87, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Radiation; Glioma; Light; Photochemotherapy; Photons; Protoporphyrins; Rats

2007
Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX.
    Lasers in surgery and medicine, 2007, Volume: 39, Issue:5

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Feasibility Studies; Glioma; Humans; Magnetic Resonance Imaging; Middle Aged; Monte Carlo Method; Neoplasm Recurrence, Local; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Radiosurgery

2007
Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid.
    Bioorganic & medicinal chemistry letters, 2007, Aug-15, Volume: 17, Issue:16

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Mice; Molecular Structure; Peptides; Permeability; Photochemotherapy; Prodrugs; Protoporphyrins; Time Factors

2007
Parasiticidal effect of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells.
    Experimental dermatology, 2007, Volume: 16, Issue:8

    Topics: Aminolevulinic Acid; Animals; Cell Line, Transformed; Disease Models, Animal; Ear, External; Interleukin-6; Leishmania major; Leishmaniasis, Cutaneous; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2007
Increase in protoporphyrin IX after 5-aminolevulinic acid based photodynamic therapy is due to local re-synthesis.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2007, Volume: 6, Issue:8

    Topics: Aminolevulinic Acid; Animals; Arterioles; Female; Fluorescence; Kinetics; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred F344; Temperature; Venules

2007
Fluorescence diagnosis in keratinocytic intraepidermal neoplasias.
    Journal of the American Academy of Dermatology, 2007, Volume: 57, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Proliferation; Diagnosis, Computer-Assisted; Diagnosis, Differential; Epidermis; Female; Fluorescence; Humans; Immunohistochemistry; Keratinocytes; Ki-67 Antigen; Male; Middle Aged; Neoplasm Staging; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms

2007
5-aminolevulinic acid-mediated photodynamic therapy on Hep-2 and MCF-7c3 cells.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2007, Volume: 26, Issue:2

    Topics: Adenocarcinoma; Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Deferoxamine; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Light; Liver Neoplasms; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2007
Cell-substrate topology upon ALA-PDT using variable-angle total internal reflection fluorescence microscopy (VA-TIRFM).
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2007, Volume: 26, Issue:2

    Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Drug Screening Assays, Antitumor; Female; Glioblastoma; HeLa Cells; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2007
Biochemical manipulation via iron chelation to enhance porphyrin production from porphyrin precursors.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2007, Volume: 26, Issue:2

    Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Esters; Fibroblasts; Fluorescence; Humans; Iron Chelating Agents; Lung; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Pyridones

2007
5-Aminolevulinic acid-induced protoporphyrin-IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines.
    Journal of photochemistry and photobiology. B, Biology, 2007, Sep-25, Volume: 88, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Biological Assay; Carcinoma, Transitional Cell; Cell Line, Tumor; Humans; Macrophages, Peritoneal; Male; Mice; Microscopy, Fluorescence; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Propidium; Protoporphyrins

2007
Comparison of aminolevulinic acid- and hexylester aminolevulinate-induced protoporphyrin IX fluorescence for the detection of ovarian cancer in a rat model.
    Photomedicine and laser surgery, 2007, Volume: 25, Issue:4

    Topics: Aminolevulinic Acid; Animals; Female; Laparoscopy; Microscopy, Fluorescence; Ovarian Neoplasms; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Spectrometry, Fluorescence; Statistics, Nonparametric

2007
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:2

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Humans; Protoporphyrins; RNA, Messenger; RNA, Small Interfering; Stomach Neoplasms

2008
Sufficient PpIX production for PDT even with short contact time of topically applied 5-ALA in rabbit tongues.
    Lasers in medical science, 2008, Volume: 23, Issue:4

    Topics: Aminolevulinic Acid; Animals; Epithelium; Male; Models, Animal; Mouth Mucosa; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rabbits; Time Factors; Tongue

2008
Sensitivity of osteoblasts, fibroblasts, bone marrow cells, and dendritic cells to 5-aminolevulinic acid based photodynamic therapy.
    Journal of photochemistry and photobiology. B, Biology, 2007, Dec-14, Volume: 89, Issue:2-3

    Topics: Alkaline Phosphatase; Aminolevulinic Acid; Animals; Bone Marrow Cells; Cell Survival; Dendritic Cells; Fibroblasts; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Osteoblasts; Photochemotherapy; Protoporphyrins

2007
Fluorescence characteristics and pharmacokinetic properties of a novel self-adhesive 5-ALA patch for photodynamic therapy of actinic keratoses.
    Archives of dermatological research, 2008, Volume: 300, Issue:2

    Topics: Adhesives; Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Case-Control Studies; Dosage Forms; Dose-Response Relationship, Drug; Environmental Exposure; Female; Fluorescence; Humans; Keratosis; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Prospective Studies; Protoporphyrins; Time Factors; Ultraviolet Rays

2008
Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy.
    International journal of oncology, 2007, Volume: 31, Issue:6

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Enzyme Inhibitors; Heme Oxygenase-1; Humans; Melanoma; Metalloporphyrins; Photochemotherapy; Protoporphyrins; RNA, Small Interfering

2007
Analyzing effects of photodynamic therapy with 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PPIX) in urothelial cells using reverse phase protein arrays.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2007, Volume: 6, Issue:12

    Topics: Aminolevulinic Acid; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Radiation; Gene Expression Profiling; Humans; Photochemotherapy; Protein Array Analysis; Protoporphyrins; Signal Transduction; Urothelium

2007
Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study.
    Brain tumor pathology, 2007, Volume: 24, Issue:2

    Topics: Aminolevulinic Acid; Brain Neoplasms; Humans; Microscopy, Fluorescence; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins

2007
The C-terminal extension of ferrochelatase is critical for enzyme activity and for functioning of the tetrapyrrole pathway in Synechocystis strain PCC 6803.
    Journal of bacteriology, 2008, Volume: 190, Issue:6

    Topics: Aminolevulinic Acid; Bacterial Proteins; Blotting, Western; Ferrochelatase; Immunoblotting; Models, Biological; Mutation; Protoporphyrins; Recombinant Proteins; Synechocystis; Tetrapyrroles

2008
Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy.
    International journal of pharmaceutics, 2008, May-22, Volume: 356, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; Chemistry, Pharmaceutical; Drug Stability; Drug Storage; Ethanol; Female; Liposomes; Mice; Mice, Inbred ICR; Mice, Nude; Particle Size; Permeability; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Absorption; Skin Neoplasms; Surface-Active Agents

2008
Glycoside esters of 5-aminolevulinic acid for photodynamic therapy of cancer.
    Bioconjugate chemistry, 2008, Volume: 19, Issue:4

    Topics: Aminolevulinic Acid; Cell Line; Cell Line, Tumor; Cell Proliferation; Endothelial Cells; Esterases; Esterification; Fibroblasts; Glycoside Hydrolases; Glycosides; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Sensitivity and Specificity

2008
Kinetics and subcellular localization of 5-ALA-induced PpIX in DHL cells via two-photon excitation fluorescence microscopy.
    International journal of oncology, 2008, Volume: 32, Issue:4

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Humans; Lymphoma, Follicular; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins

2008
5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institutuion.
    Swiss medical weekly, 2008, Mar-22, Volume: 138, Issue:11-12

    Topics: Aminolevulinic Acid; Biopsy; Fluorescence; Glioma; Humans; Prognosis; Protoporphyrins; Sensitivity and Specificity

2008
A HCl/alcohol formulation increased 5-aminolevulinic acid skin distribution using an ex vivo full thickness porcine skin model.
    Experimental dermatology, 2008, Volume: 17, Issue:10

    Topics: Alcohols; Aminolevulinic Acid; Animals; Female; Hydrochloric Acid; Microscopy, Fluorescence; Models, Animal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Surgical Tape; Sus scrofa

2008
Selective accumulation of PpIX and photodynamic effect after aminolevulinic acid treatment of human adenomyosis xenografts in nude mice.
    Fertility and sterility, 2008, Volume: 90, Issue:4 Suppl

    Topics: Adult; Aminolevulinic Acid; Animals; Endometriosis; Female; Humans; Injections, Intraperitoneal; Japan; Mice; Mice, Nude; Middle Aged; Photochemotherapy; Protoporphyrins; Transplantation, Heterologous

2008
Relationship of protoporphyrin IX synthesis to photodynamic effects by 5-aminolaevulinic acid and its esters on various cell lines derived from the skin.
    The British journal of dermatology, 2008, Volume: 159, Issue:1

    Topics: Aminolevulinic Acid; Cell Death; Cell Line; Dose-Response Relationship, Drug; Esters; Flow Cytometry; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Tumor Cells, Cultured

2008
Protoporphyrin IX fluorescence photobleaching is a useful tool to predict the response of rat ovarian cancer following hexaminolevulinate photodynamic therapy.
    Lasers in surgery and medicine, 2008, Volume: 40, Issue:5

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Female; Microscopy, Fluorescence; Ovarian Neoplasms; Photobleaching; Photochemotherapy; Photosensitizing Agents; Predictive Value of Tests; Protoporphyrins; Rats; Rats, Inbred F344; Reproducibility of Results

2008
5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:6

    Topics: Aminolevulinic Acid; Animals; Cell Death; Cell Line; Endocytosis; Esterases; Female; Fluorescein; Fluorescence; In Vitro Techniques; Kinetics; Mice; Peptides; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin; Swine

2008
Microscopic localisation of protoporphyrin IX in normal mouse skin after topical application of 5-aminolevulinic acid or methyl 5-aminolevulinate.
    Journal of photochemistry and photobiology. B, Biology, 2008, Aug-21, Volume: 92, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Mice; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Skin

2008
Regulation of 5-aminolevulinic acid-dependent protoporphyrin IX accumulations in human histiocytic lymphoma U937 cells.
    Physiological chemistry and physics and medical NMR, 2007, Volume: 39, Issue:1

    Topics: Aminolevulinic Acid; Chlorides; Deferoxamine; Humans; Lymphoma, Large B-Cell, Diffuse; Manganese Compounds; Mesoporphyrins; Protoporphyrins; U937 Cells

2007
Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jul-15, Volume: 14, Issue:14

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms

2008
In vivo mitochondrial oxygen tension measured by a delayed fluorescence lifetime technique.
    Biophysical journal, 2008, Volume: 95, Issue:8

    Topics: Aminolevulinic Acid; Animals; Calibration; Cell Separation; Hepatocytes; Injections, Intravenous; Liver; Male; Microscopy, Fluorescence; Mitochondria, Liver; Oxygen; Partial Pressure; Protoporphyrins; Rats; Rats, Wistar; Reperfusion Injury; Time Factors

2008
Analysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2008, Volume: 7, Issue:9

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Microscopy, Electron, Transmission; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms

2008
Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy.
    Journal of experimental therapeutics & oncology, 2008, Volume: 7, Issue:2

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzothiazoles; Blotting, Western; Cell Line, Tumor; Chlorophyll; Chromatography, High Pressure Liquid; Diamines; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Heme Oxygenase-1; Humans; Neoplasm Proteins; Neoplasms; NF-E2-Related Factor 2; Organic Chemicals; Oxidative Stress; Photochemistry; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Quinolines; RNA, Messenger; RNA, Small Interfering; Transfection

2008
Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy.
    Translational research : the journal of laboratory and clinical medicine, 2008, Volume: 152, Issue:3

    Topics: Aminolevulinic Acid; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Stability; Humans; Isothiocyanates; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Sulfoxides; Thiocyanates

2008
Effects of PDT with 5-aminolevulinic acid and chitosan on Walker carcinosarcoma.
    Experimental oncology, 2008, Volume: 30, Issue:3

    Topics: Aminolevulinic Acid; Animals; Anticholesteremic Agents; Carcinosarcoma; Chitosan; Combined Modality Therapy; Drug Therapy, Combination; Light; Lipid Peroxidation; Male; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar

2008
Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma.
    Journal of photochemistry and photobiology. B, Biology, 2008, Dec-11, Volume: 93, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Dose-Response Relationship, Drug; Female; Humans; Male; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Time Factors

2008
Microscopic distribution of protoporphyrin (PpIX) fluorescence in superficial basal cell carcinoma during light-fractionated aminolaevulinic acid photodynamic therapy.
    Acta dermato-venereologica, 2008, Volume: 88, Issue:6

    Topics: Aminolevulinic Acid; Biopsy; Carcinoma, Basal Cell; Humans; Immunohistochemistry; Ki-67 Antigen; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms

2008
Etretinate enhances the susceptibility of human skin squamous cell carcinoma cells to 5-aminolaevulic acid-based photodynamic therapy.
    Clinical and experimental dermatology, 2009, Volume: 34, Issue:3

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Death; Dose-Response Relationship, Drug; Drug Evaluation; Drug Synergism; Etretinate; Humans; Keratolytic Agents; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Tumor Cells, Cultured

2009
Sustained and efficient porphyrin generation in vivo using dendrimer conjugates of 5-ALA for photodynamic therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2009, Apr-17, Volume: 135, Issue:2

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Coloring Agents; Dendrimers; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Molecular Structure; Molecular Weight; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Time Factors; Xenograft Model Antitumor Assays

2009
Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells.
    The British journal of dermatology, 2009, Volume: 160, Issue:4

    Topics: Administration, Topical; Aminolevulinic Acid; Humans; Keratosis, Actinic; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Psoriasis; Skin Absorption; Spectrometry, Fluorescence

2009
Influence of formulation factors on PpIX production and photodynamic action of novel ALA-loaded microparticles.
    Biopharmaceutics & drug disposition, 2009, Volume: 30, Issue:2

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Female; Gels; Mice; Mice, Inbred BALB C; Mice, Nude; Microspheres; Neoplasms, Experimental; Photochemotherapy; Photosensitizing Agents; Propylene Glycol; Protoporphyrins; Skin Neoplasms

2009
Mitochondrial oxygen tension within the heart.
    Journal of molecular and cellular cardiology, 2009, Volume: 46, Issue:6

    Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Flow Cytometry; Heart; Male; Microscopy, Fluorescence; Mitochondria, Heart; Oxygen Consumption; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar

2009
Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism.
    British journal of cancer, 2009, Mar-10, Volume: 100, Issue:5

    Topics: Aminolevulinic Acid; Animals; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Gene Knockdown Techniques; Intracellular Space; Mice; Models, Biological; Peptide Hydrolases; Peptides; Prodrugs; Protoporphyrins; RNA Interference; RNA, Small Interfering

2009
Treatment of perianal Paget's disease using photodynamic therapy with assistance of fluorescence examination: case report.
    Lasers in medical science, 2009, Volume: 24, Issue:6

    Topics: Aged; Aminolevulinic Acid; Anus Neoplasms; Female; Fluorescence; Humans; Laser Therapy; Paget Disease, Extramammary; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2009
[Two-photon excitation fluorescence of 5-ALA induced PpIX in DHL cells].
    Guang pu xue yu guang pu fen xi = Guang pu, 2008, Volume: 28, Issue:11

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Gene Expression; Humans; Kinetics; Microscopy, Confocal; Microscopy, Fluorescence; Photons; Protoporphyrins

2008
Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells.
    The British journal of dermatology, 2009, Volume: 161, Issue:2

    Topics: Aminolevulinic Acid; Calcitriol; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Stem Cell Assay

2009
Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white light.
    Photodiagnosis and photodynamic therapy, 2009, Volume: 6, Issue:1

    Topics: Aminolevulinic Acid; Anthracenes; Apoptosis; Cell Line, Tumor; Drug Synergism; Endometrial Neoplasms; Female; Humans; Light; Perylene; Photosensitizing Agents; Protoporphyrins

2009
Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, May-15, Volume: 15, Issue:10

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coproporphyrinogen Oxidase; Dose-Response Relationship, Drug; Ferrochelatase; Filaggrin Proteins; Humans; Keratinocytes; Light; Methotrexate; Mice; Mice, Nude; Neoplasms, Experimental; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Xenograft Model Antitumor Assays

2009
A comparison of 5-aminolaevulinic acid- and its heptyl ester: dark cytotoxicity and protoporphyrin IX synthesis in human adenocarcinoma WiDr cells and in athymic nude mice healthy skin.
    Experimental dermatology, 2009, Volume: 18, Issue:11

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Skin; Skin Neoplasms; Spectrometry, Fluorescence

2009
Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization.
    Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13

    Topics: Aminolevulinic Acid; Animals; Cell Line; Dipeptides; Humans; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Structure-Activity Relationship

2009
Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
    International journal of cancer, 2009, Oct-01, Volume: 125, Issue:7

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Kaplan-Meier Estimate; Mice; Mice, Inbred Strains; Papilloma; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate

2009
Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: inhibitory effects of nitric oxide.
    Free radical biology & medicine, 2009, Sep-15, Volume: 47, Issue:6

    Topics: Aminolevulinic Acid; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cytoprotection; Female; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2009
Parallel pigment and transcriptomic analysis of four barley albina and xantha mutants reveals the complex network of the chloroplast-dependent metabolism.
    Plant molecular biology, 2009, Volume: 71, Issue:1-2

    Topics: Aminolevulinic Acid; Chloroplasts; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Plant; Hordeum; Lyases; Plant Proteins; Protein Subunits; Protoporphyrins; RNA, Messenger; Transcription, Genetic

2009
Precise detection of lymph node metastases in mouse rectal cancer by using 5-aminolevulinic acid.
    International journal of cancer, 2009, Nov-15, Volume: 125, Issue:10

    Topics: Aminolevulinic Acid; Animals; Female; Green Fluorescent Proteins; Humans; Lymph Nodes; Lymphatic Metastasis; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Photosensitizing Agents; Protoporphyrins; Rectal Neoplasms; Tumor Cells, Cultured

2009
Porphyrin synthesis from aminolevulinic acid esters in endothelial cells and its role in photodynamic therapy.
    Journal of photochemistry and photobiology. B, Biology, 2009, Sep-04, Volume: 96, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Line; Endothelial Cells; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Ultraviolet Rays

2009
Endogenous and exogenous porphyrins as photosensitizers in the Hep-2 human carcinoma cell line.
    Cellular and molecular biology (Noisy-le-Grand, France), 2009, Jul-01, Volume: 55, Issue:2

    Topics: Aminolevulinic Acid; Carcinoma; Cell Line, Tumor; Cell Survival; Fullerenes; Humans; Laryngeal Neoplasms; Light; Liposomes; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins

2009
Ros production by endogenously generated Protoporphyrin IX in murine leukemia cells.
    Cellular and molecular biology (Noisy-le-Grand, France), 2009, Jul-01, Volume: 55, Issue:2

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Leukemia; Membrane Potential, Mitochondrial; Mice; Mitochondria; Photochemotherapy; Protoporphyrins; Reactive Oxygen Species; Superoxides; Ultraviolet Rays

2009
Topical delivery of 5-aminolevulinic acid-encapsulated ethosomes in a hyperproliferative skin animal model using the CLSM technique to evaluate the penetration behavior.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2009, Volume: 73, Issue:3

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Female; Liposomes; Mice; Mice, Inbred ICR; Mice, Nude; Microscopy, Confocal; Permeability; Phosphatidylethanolamines; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Skin Absorption; Tumor Necrosis Factor-alpha

2009
Desferrioxamine shows different potentials for enhancing 5-aminolaevulinic acid-based photodynamic therapy in several cutaneous cell lines.
    Lasers in medical science, 2010, Volume: 25, Issue:2

    Topics: Aminolevulinic Acid; Cell Death; Cell Line; Deferoxamine; Drug Synergism; Fibroblasts; Humans; Iron Chelating Agents; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Diseases

2010
5-ALA derivative-mediated photoinactivation of Propionibacterium acnes.
    Journal of dermatological science, 2009, Volume: 56, Issue:3

    Topics: Aminolevulinic Acid; Gram-Positive Bacterial Infections; Humans; Light; Photochemotherapy; Propionibacterium acnes; Protoporphyrins

2009
Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937.
    Cell biochemistry and function, 2009, Volume: 27, Issue:8

    Topics: Aminolevulinic Acid; Apoptosis; Enzyme Inhibitors; Ferrochelatase; Humans; Light; Lymphoma, Large B-Cell, Diffuse; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; U937 Cells

2009
Topical aminolaevulinic acid- and aminolaevulinic acid methyl ester-based photodynamic therapy with red and violet light: influence of wavelength on pain and erythema.
    The British journal of dermatology, 2009, Volume: 161, Issue:5

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Animals; Erythema; Humans; Lasers; Mice; Mice, Nude; Middle Aged; Pain; Pain Measurement; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors

2009
Photochemically induced increase in endothelial permeability regulated by RhoA activation.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2009, Volume: 8, Issue:10

    Topics: Actins; Aminolevulinic Acid; Antigens, CD; Cadherins; Endothelial Cells; Enzyme Activation; Humans; Intracellular Space; Light; Permeability; Photochemical Processes; Photochemotherapy; Prodrugs; Protoporphyrins; rhoA GTP-Binding Protein

2009
Silencing of ALA dehydratase affects ALA-photodynamic therapy efficacy in K562 erythroleukemic cells.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2009, Volume: 8, Issue:10

    Topics: Aminolevulinic Acid; Cell Death; Gene Silencing; Humans; K562 Cells; Leukemia, Erythroblastic, Acute; Mitochondria; Photochemotherapy; Porphobilinogen Synthase; Protoporphyrins

2009
Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDT.
    Lasers in surgery and medicine, 2009, Volume: 41, Issue:9

    Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Models, Cardiovascular; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Regional Blood Flow; Skin Neoplasms; Spectrometry, Fluorescence

2009
The effects of keratolytic pretreatment prior to fluorescence diagnosis and photodynamic therapy with aminolevulinic acid-induced porphyrins in psoriasis.
    The Journal of dermatological treatment, 2010, Volume: 21, Issue:4

    Topics: Administration, Topical; Aged; Aminolevulinic Acid; Analysis of Variance; Bandages, Hydrocolloid; Biopsy, Needle; Female; Fluorescence; Humans; Immunohistochemistry; Keratolytic Agents; Male; Middle Aged; Photochemotherapy; Pilot Projects; Probability; Protoporphyrins; Psoriasis; Skin Absorption; Treatment Outcome; Tretinoin

2010
Fluorescence induction of protoporphyrin IX by a new 5-aminolevulinic acid nanoemulsion used for photodynamic therapy in a full-thickness ex vivo skin model.
    Experimental dermatology, 2010, Volume: 19, Issue:8

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Emulsions; Fluorescence; Models, Animal; Photochemotherapy; Protoporphyrins; Skin; Skin Absorption; Swine

2010
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target.
    PloS one, 2009, Oct-28, Volume: 4, Issue:10

    Topics: Aminolevulinic Acid; Anti-Infective Agents; Antineoplastic Agents; Artemisinins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Heme; Humans; Iron; Models, Chemical; Protoporphyrins; Spectrophotometry; Transferrin

2009
Synergistic increase in osteosarcoma cell sensitivity to photodynamic therapy with aminolevulinic acid hexyl ester in the presence of hyperthermia.
    Photomedicine and laser surgery, 2009, Volume: 27, Issue:5

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Combined Modality Therapy; Humans; Hyperthermia, Induced; Infrared Rays; Mandibular Neoplasms; Osteosarcoma; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2009
Heating increases protoporphyrin IX production in normal skin after delivery of 5-aminolevulinic acid by iontophoresis.
    Photodermatology, photoimmunology & photomedicine, 2009, Volume: 25, Issue:6

    Topics: Adult; Aminolevulinic Acid; Hot Temperature; Humans; Iontophoresis; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms

2009
Anticancer effect of photodynamic therapy with hexenyl ester of 5-aminolevulinic acid in oral squamous cell carcinoma.
    Head & neck, 2010, Volume: 32, Issue:9

    Topics: Aminolevulinic Acid; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; Cell Death; Cell Survival; Flow Cytometry; Humans; Mouth Neoplasms; Photochemotherapy; Protoporphyrins; Reactive Oxygen Species; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2010
Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX accumulation in human urothelial carcinomas.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 2009, Volume: 76, Issue:6

    Topics: Aminolevulinic Acid; beta-Alanine; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carcinoma, Transitional Cell; Cell Line, Tumor; Deferoxamine; Ferrochelatase; Flow Cytometry; Humans; Microscopy, Fluorescence; Mitochondria; Nitroso Compounds; Oxidative Phosphorylation; Photosensitizing Agents; Protoporphyrins; Time Factors; Urinary Bladder Neoplasms; Urothelium

2009
Intralesional photodynamic therapy: a comment on 'Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy' by Gerritsen et al.
    Dermatology (Basel, Switzerland), 2010, Volume: 220, Issue:1

    Topics: Aminolevulinic Acid; Humans; Injections, Intralesional; Photochemotherapy; Protoporphyrins; Skin Neoplasms

2010
A comparative study on the enhancement efficacy of specific and non-specific iron chelators for protoporphyrin IX production and photosensitization in HaCat cells.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2009, Volume: 29, Issue:6

    Topics: Aminolevulinic Acid; Cell Line, Transformed; Deferoxamine; Edetic Acid; Humans; Iron Chelating Agents; Keratinocytes; Photosensitivity Disorders; Photosensitizing Agents; Protoporphyrins

2009
Hexaminolevulinate-mediated photodynamic purging of leukemia cells from BM.
    Bone marrow transplantation, 2010, Volume: 45, Issue:10

    Topics: Aminolevulinic Acid; Animals; Bone Marrow Cells; Bone Marrow Purging; Bone Marrow Transplantation; Cell Line, Tumor; Cell Survival; Female; Gamma Rays; Granulocytes; Leukemia L1210; Mice; Mice, Inbred DBA; Osmolar Concentration; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Survival Analysis; Tumor Stem Cell Assay; Whole-Body Irradiation

2010
[Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
    Medicina (Kaunas, Lithuania), 2009, Volume: 45, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chi-Square Distribution; Esters; Female; Fluorescence; Follow-Up Studies; Head and Neck Neoplasms; Humans; Male; Middle Aged; Photosensitizing Agents; Precancerous Conditions; Prognosis; Protoporphyrins; Sensitivity and Specificity; Skin; Skin Neoplasms

2009
Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells.
    Bioconjugate chemistry, 2010, Apr-21, Volume: 21, Issue:4

    Topics: Aminolevulinic Acid; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Chitosan; Colorectal Neoplasms; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Nanoparticles; Protoporphyrins; Receptors, Cell Surface

2010
Fractional laser as a tool to enhance the skin permeation of 5-aminolevulinic acid with minimal skin disruption: a comparison with conventional erbium:YAG laser.
    Journal of controlled release : official journal of the Controlled Release Society, 2010, Jul-14, Volume: 145, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Fluorescence; Lasers; Lasers, Solid-State; Light; Mice; Mice, Nude; Microscopy, Confocal; Protoporphyrins; Skin; Skin Absorption; Specific Pathogen-Free Organisms; Swine

2010
Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.
    Journal of neurosurgery, 2011, Volume: 114, Issue:3

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Data Interpretation, Statistical; Female; Fluorescence; Glioma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Microscopy, Fluorescence; Middle Aged; Neurosurgical Procedures; Paraffin Embedding; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted

2011
The influence of temperature on 5-aminolevulinic acid-based photodynamic reaction in keratinocytes in vitro.
    Photodermatology, photoimmunology & photomedicine, 2010, Volume: 26, Issue:2

    Topics: Aminolevulinic Acid; Cell Death; Cell Line; Cytokines; Hot Temperature; Humans; Keratinocytes; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2010
Photodynamic therapy with intradermal administration of 5-aminolevulinic acid for port-wine stains.
    The Journal of dermatological treatment, 2010, Volume: 21, Issue:4

    Topics: Aminolevulinic Acid; Animals; Chickens; Disease Models, Animal; Female; Injections, Intradermal; Injections, Intravenous; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Port-Wine Stain; Probability; Protoporphyrins; Random Allocation; Skin Absorption

2010
Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT.
    Photodiagnosis and photodynamic therapy, 2010, Volume: 7, Issue:2

    Topics: Aged; Aminolevulinic Acid; Dose-Response Relationship, Drug; Fluorescence; Humans; Keratosis, Actinic; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Skin; Skin Neoplasms

2010
Demonstration of protoporphyrin IX (PpIX) localized to areas of palmar skin injected with 5-aminolevulinic acid (ALA) and pre-treated with a fractionated CO2 laser prior to topically applied ALA.
    Photodiagnosis and photodynamic therapy, 2010, Volume: 7, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Humans; Iontophoresis; Lasers, Gas; Photosensitizing Agents; Protoporphyrins; Skin

2010
Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:4

    Topics: Aminolevulinic Acid; Animals; Anthracenes; Antineoplastic Agents; Female; Fluorescence; Perylene; Photochemotherapy; Povidone; Protoporphyrins; Rats; Rats, Inbred F344; Solubility; Tissue Distribution; Urinary Bladder Neoplasms

2011
Factors influencing pain intensity during topical photodynamic therapy of complete cosmetic units for actinic keratoses.
    Journal of the American Academy of Dermatology, 2010, Volume: 63, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cosmetic Techniques; Female; Humans; Keratosis, Actinic; Male; Middle Aged; Nerve Endings; Pain; Pain Measurement; Photochemotherapy; Protoporphyrins; Retrospective Studies; Sex Characteristics; Treatment Outcome

2010
Metronomic PDT and cell death pathways.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 635

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Electrophoresis; Humans; Intracellular Space; Oligonucleotide Array Sequence Analysis; Photochemotherapy; Polymerase Chain Reaction; Protoporphyrins; Rats; Receptors, Tumor Necrosis Factor; Reproducibility of Results

2010
Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivo.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 635

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Female; Humans; Mice; Optical Fibers; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence

2010
A case of Bowen's disease successfully treated by photodynamic therapy.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2010, Volume: 77, Issue:3

    Topics: Aminolevulinic Acid; Bowen's Disease; Female; Humans; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Treatment Outcome

2010
Penetration enhancement of two topical 5-aminolaevulinic acid formulations for photodynamic therapy by erbium:YAG laser ablation of the stratum corneum: continuous versus fractional ablation.
    Experimental dermatology, 2010, Volume: 19, Issue:9

    Topics: Aminolevulinic Acid; Animals; Epidermis; Feasibility Studies; Female; Lasers, Solid-State; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Swine

2010
Improving intraoperative visualization of anaplastic foci within gliomas.
    Neurosurgery, 2010, Volume: 67, Issue:2

    Topics: Aminolevulinic Acid; Biopsy; Brain Neoplasms; Carcinoma; Fluorescence; Glioma; Humans; Protoporphyrins; Radiosurgery

2010
Effect and mechanism of 5-aminolevulinic acid-mediated photodynamic therapy in esophageal cancer.
    Lasers in medical science, 2011, Volume: 26, Issue:1

    Topics: Aminolevulinic Acid; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Female; Genes, bcl-2; Humans; Lasers; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; RNA, Messenger; RNA, Neoplasm

2011
The role of nitric oxide in the treatment of tumours with aminolaevulinic acid-induced photodynamic therapy.
    Journal of photochemistry and photobiology. B, Biology, 2010, Dec-02, Volume: 101, Issue:3

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cell Line, Tumor; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitroarginine; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2010
Reduction of cutaneous photosensitivity by application of ointment containing ferrous or cobaltous ions concomitant with the use of topical protoporphyrin IX precursors.
    Photodiagnosis and photodynamic therapy, 2010, Volume: 7, Issue:3

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Cobalt; Female; Ferrous Compounds; Mice; Mice, Inbred BALB C; Photosensitivity Disorders; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Zinc Sulfate

2010
In vivo temporal evolution of ALA-induced normalized fluorescence at different anatomical locations of oral cavity: application to improve cancer diagnostic contrast and potential.
    Photodiagnosis and photodynamic therapy, 2010, Volume: 7, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosis, Oral; Humans; Mouth; Mouth Diseases; Mouth Mucosa; Mouth Neoplasms; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence; Time Factors

2010
The efficacy of photodynamic diagnosis in defining the lateral border between a tumor and a tumor-free area during Mohs micrographic surgery.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:11

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorescence; Humans; Male; Middle Aged; Mohs Surgery; Neoplasm Staging; Photosensitizing Agents; Protoporphyrins; Retrospective Studies; Skin Neoplasms

2010
Detection and photodynamic therapy of inflamed atherosclerotic plaques in the carotid artery of rabbits.
    Journal of photochemistry and photobiology. B, Biology, 2011, Jan-10, Volume: 102, Issue:1

    Topics: Aminolevulinic Acid; Animals; Carotid Arteries; Inflammation; Macrophages; Male; Phagocytosis; Photochemotherapy; Plaque, Atherosclerotic; Protoporphyrins; Rabbits; Spectrometry, Fluorescence

2011
Two-photon irradiation of an intracellular singlet oxygen photosensitizer: achieving localized sub-cellular excitation in spatially-resolved experiments.
    Free radical research, 2010, Volume: 44, Issue:12

    Topics: Aminolevulinic Acid; Apoptosis; Cell Adhesion; Cell Line, Tumor; Humans; Lasers; Microscopy, Fluorescence; Mitochondria; Photons; Photosensitizing Agents; Protoporphyrins; Single-Cell Analysis; Singlet Oxygen

2010
Quinolone compounds enhance delta-aminolevulinic acid-induced accumulation of protoporphyrin IX and photosensitivity of tumour cells.
    Journal of biochemistry, 2011, Volume: 149, Issue:2

    Topics: Aminolevulinic Acid; Drug Synergism; Female; Ferric Compounds; Fluoroquinolones; HeLa Cells; Heme Oxygenase (Decyclizing); Hemin; Humans; Iron; Light; Metalloporphyrins; Nitrilotriacetic Acid; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Skin Neoplasms

2011
Hexaminolevulinate-mediated photodynamic purging of marrow grafts with murine breast carcinoma.
    Bone marrow transplantation, 2011, Volume: 46, Issue:8

    Topics: Aminolevulinic Acid; Animals; Bone Marrow; Bone Marrow Purging; Cell Line, Tumor; Female; Hematopoietic Stem Cell Transplantation; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured

2011
Determination of time-dependent protoporphyrin IX concentration for photodynamic therapy dosimetry in a mice colon tumor model using fluorescence spectroscopy.
    Applied spectroscopy, 2010, Volume: 64, Issue:12

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Female; Kinetics; Male; Mice; Mice, Inbred BALB C; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence

2010
Evaluation of photodynamic therapy (PDT) procedures using microfluidic system.
    Analytica chimica acta, 2011, Jan-10, Volume: 683, Issue:2

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Dimethylpolysiloxanes; Humans; Lab-On-A-Chip Devices; Lung Neoplasms; Microfluidic Analytical Techniques; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2011
Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence.
    Brain tumor pathology, 2011, Volume: 28, Issue:1

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Magnetic Resonance Angiography; Male; Methylation; Middle Aged; Neuronavigation; Polymerase Chain Reaction; Protoporphyrins; Spectrometry, Fluorescence; Tumor Suppressor Proteins

2011
Precise comparison of protoporphyrin IX fluorescence spectra with pathological results for brain tumor tissue identification.
    Brain tumor pathology, 2011, Volume: 28, Issue:1

    Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Spectrum Analysis

2011
Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy.
    British journal of cancer, 2011, Mar-01, Volume: 104, Issue:5

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Ferrochelatase; Fluorescence; Gene Silencing; Glioma; Humans; Photochemotherapy; Protoporphyrins

2011
Enhancement of blood porphyrin emission intensity with aminolevulinic acid administration: a new concept for photodynamic diagnosis of early prostate cancer.
    Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:1

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cell Line, Tumor; Drug Synergism; Drug Therapy, Combination; Early Diagnosis; Image Enhancement; Male; Mice; Mice, Nude; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Radiation Tolerance; Sensitivity and Specificity

2011
Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification.
    Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:1

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Drug Combinations; Female; Humans; Male; Metabolic Clearance Rate; Microscopy, Fluorescence; Middle Aged; Organ Specificity; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Tissue Distribution; Treatment Outcome

2011
Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes.
    The Journal of dermatology, 2011, Volume: 38, Issue:7

    Topics: Acne Vulgaris; Aminolevulinic Acid; Anti-Bacterial Agents; Coproporphyrins; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Photochemotherapy; Photosensitizing Agents; Propionibacterium acnes; Protoporphyrins

2011
5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor.
    Lung cancer (Amsterdam, Netherlands), 2011, Volume: 74, Issue:1

    Topics: Aminolevulinic Acid; Animals; Carcinoma; Cell Line, Tumor; Fluorescence; Humans; Lung Neoplasms; Mesothelioma; Mice; Mice, SCID; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasms, Experimental; Photosensitizing Agents; Pleural Neoplasms; Protoporphyrins; Sensitivity and Specificity; Tumor Burden

2011
Intense pulse light and 5-ALA PDT: phototoxic effects in vitro depend on the spectral overlap with protoporphyrine IX but do not match cut-off filter notations.
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:2

    Topics: Aminolevulinic Acid; Cell Survival; Clinical Protocols; Dose-Response Relationship, Radiation; Humans; In Vitro Techniques; Keratinocytes; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrum Analysis

2011
Measuring versus seeing.
    Journal of neurosurgery, 2011, Volume: 115, Issue:1

    Topics: Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Fluorescence; Humans; Magnetic Resonance Imaging; Photosensitizing Agents; Protoporphyrins

2011
Simulation of fractionated and continuous irradiation in photodynamic therapy: study the differences between photobleaching and singlet oxygen dose deposition.
    Australasian physical & engineering sciences in medicine, 2011, Volume: 34, Issue:2

    Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Computer Simulation; Mice; Mice, Inbred BALB C; Models, Biological; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen; Spectrometry, Fluorescence

2011
Drug delivery technologies and immunological aspects of photodynamic therapy.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2011, Volume: 10, Issue:5

    Topics: Aminolevulinic Acid; Drug Carriers; Humans; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2011
An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin.
    Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:2

    Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Back; Female; Fluorescence; Forearm; Humans; Leg; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2011
Isolation and characterization of squamous carcinoma cells resistant to photodynamic therapy.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:9

    Topics: Aminolevulinic Acid; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Nucleus Shape; Cell Shape; Cell Survival; Cytoskeletal Proteins; Drug Resistance, Neoplasm; Humans; Inhibitor of Apoptosis Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Ubiquitin-Protein Ligases

2011
Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways.
    Investigational new drugs, 2012, Volume: 30, Issue:3

    Topics: Aminolevulinic Acid; Cell Death; Cell Line, Tumor; Glioblastoma; Humans; Hydroxymethylbilane Synthase; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Photochemotherapy; Prodrugs; Protoporphyrins; Reactive Oxygen Species

2012
Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas.
    Journal of biomedical optics, 2011, Volume: 16, Issue:4

    Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Models, Biological; Monte Carlo Method; Phantoms, Imaging; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen; Skin Neoplasms; Spectrometry, Fluorescence

2011
Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas.
    Neurosurgical focus, 2011, Volume: 30, Issue:5

    Topics: Aminolevulinic Acid; Diagnostic Imaging; Female; Humans; Meningeal Neoplasms; Meningioma; Middle Aged; Photosensitizing Agents; Protoporphyrins; Skull Base Neoplasms

2011
The centrality of PBGD expression levels on ALA-PDT efficacy.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2011, Volume: 10, Issue:8

    Topics: Aminolevulinic Acid; Apoptosis; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylbilane Synthase; K562 Cells; Leukemia, Erythroblastic, Acute; Light; Photochemotherapy; Porphobilinogen Synthase; Protoporphyrins; RNA Interference; RNA, Small Interfering

2011
Targeting of sebaceous glands by δ-aminolevulinic acid-based photodynamic therapy: An in vivo study.
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:5

    Topics: Acne Vulgaris; Aminolevulinic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sebaceous Glands; Skin; Spectrometry, Fluorescence

2011
Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells.
    Molecular and cellular biochemistry, 2011, Volume: 358, Issue:1-2

    Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cattle; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Space; Ferrochelatase; Gene Expression Regulation; Gene Knockdown Techniques; Heme; Humans; Indoles; Neoplasm Proteins; Nitroso Compounds; Protoporphyrins; Serum; Serum Albumin, Bovine

2011
Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells.
    International journal of nanomedicine, 2011, Volume: 6

    Topics: Aminolevulinic Acid; Annexin A5; Apoptosis; Cell Line, Tumor; Cholangiocarcinoma; Flow Cytometry; Humans; Necrosis; Photochemotherapy; Photomicrography; Photosensitizing Agents; Propidium; Protoporphyrins; Reactive Oxygen Species

2011
Oxygen-dependent delayed fluorescence measured in skin after topical application of 5-aminolevulinic acid.
    Journal of biophotonics, 2011, Volume: 4, Issue:10

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Fluorescence; Male; Oxygen; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Skin; Skin Neoplasms; Spectrometry, Fluorescence; Time Factors

2011
Retained topical delivery of 5-aminolevulinic acid using cationic ultradeformable liposomes for photodynamic therapy.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Sep-18, Volume: 44, Issue:1-2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Cations; Drug Compounding; Drug Stability; In Vitro Techniques; Liposomes; Male; Mice; Mice, Hairless; Particle Size; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Absorption; Skin Diseases; Surface Properties

2011
Fluorescence illuminates the way ...
    Neuro-oncology, 2011, Volume: 13, Issue:8

    Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Male; Monitoring, Intraoperative; Protoporphyrins

2011
δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy.
    Neuro-oncology, 2011, Volume: 13, Issue:8

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Diagnostic Imaging; Female; Fluorescence; Fluorometry; Glioma; Humans; Immunoenzyme Techniques; Male; Microscopy, Fluorescence; Middle Aged; Monitoring, Intraoperative; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Young Adult

2011
Comparative study of protoporphyrin IX fluorescence image enhancement methods to improve an optical imaging system for oral cancer detection.
    Journal of biomedical optics, 2011, Volume: 16, Issue:7

    Topics: Aminolevulinic Acid; Diagnostic Imaging; Fluorescence; Humans; Image Enhancement; Mouth Neoplasms; Optical Phenomena; Photosensitizing Agents; Protoporphyrins

2011
¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis.
    Cancer, 2012, Mar-15, Volume: 118, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Carbon Radioisotopes; Cell Count; Cell Proliferation; Female; Fluorescence; Glioma; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Positron-Emission Tomography; Protoporphyrins; Regression Analysis

2012
Photodynamic therapy (PDT) - Initiation of apoptosis via activation of stress-activated p38 MAPK and JNK signal pathway in H460 cell lines.
    Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:3

    Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Coloring Agents; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Signal Transduction; Tetrazolium Salts; Thiazoles; Up-Regulation

2011
Photobleaching-based method to individualize irradiation time during interstitial 5-aminolevulinic acid photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:3

    Topics: Absorption; Algorithms; Aminolevulinic Acid; Brain Neoplasms; Computer Simulation; Finite Element Analysis; Fluorescence; Glioblastoma; Humans; Models, Biological; Models, Chemical; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation Dosage; Radiometry; Scattering, Radiation; Time Factors

2011
Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2011, Volume: 10, Issue:11

    Topics: Aminolevulinic Acid; Apoptosis; Calcium; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Endoplasmic Reticulum; Humans; Light; Lymphoma; Mitochondria; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Protoporphyrins; Sarcoplasmic Reticulum Calcium-Transporting ATPases

2011
δ-Aminolevulinic acid and its methyl ester induce the formation of Protoporphyrin IX in cultured sensory neurones.
    Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 384, Issue:6

    Topics: Amino Acid Transport Systems; Aminolevulinic Acid; Animals; Biological Transport; Cells, Cultured; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; Ganglia, Spinal; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Time Factors

2011
Protoporphyrin IX fluorescence contrast in invasive glioblastomas is linearly correlated with Gd enhanced magnetic resonance image contrast but has higher diagnostic accuracy.
    Journal of biomedical optics, 2011, Volume: 16, Issue:9

    Topics: Aminolevulinic Acid; Animals; Area Under Curve; Cell Line, Tumor; Diffusion; Gadolinium; Glioblastoma; Histocytochemistry; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Protoporphyrins; ROC Curve; Spectrometry, Fluorescence

2011
Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy.
    Journal of dermatological science, 2011, Volume: 64, Issue:3

    Topics: Adult; Aged; Aminolevulinic Acid; Apoptosis; Blotting, Western; Case-Control Studies; Caspase 3; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type III; Combined Modality Therapy; Electric Stimulation Therapy; Enzyme Activation; Female; Fibroblasts; Flow Cytometry; Gene Expression Regulation; Humans; Keloid; L-Lactate Dehydrogenase; Male; Matrix Metalloproteinase 2; Membrane Potential, Mitochondrial; Middle Aged; Necrosis; Photochemotherapy; Photosensitizing Agents; Polymerase Chain Reaction; Protoporphyrins; Reactive Oxygen Species; Time Factors

2011
Modulating ALA-PDT efficacy of mutlidrug resistant MCF-7 breast cancer cells using ALA prodrug.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2011, Volume: 10, Issue:12

    Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Levulinic Acids; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins

2011
Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 80, Issue:2

    Topics: Aminolevulinic Acid; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Survival; Cholangiocarcinoma; Excipients; Humans; Photochemotherapy; Photosensitizing Agents; Poloxamer; Polysorbates; Protoporphyrins; Surface-Active Agents

2012
Fluorescence detection and depletion of T47D breast cancer cells from human mononuclear cell-enriched blood preparations by photodynamic treatment: Basic in vitro experiments towards the removal of circulating tumor cells.
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:7

    Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Endothelial Cells; Erythrocytes; Female; Flow Cytometry; Humans; Leukocytes, Mononuclear; Neoplastic Cells, Circulating; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats

2011
Intracutaneous ALA photodynamic therapy: dose-dependent targeting of skin structures.
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:7

    Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Subcutaneous Fat; Swine

2011
Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery.
    Journal of biomedical optics, 2011, Volume: 16, Issue:11

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Diagnostic Imaging; Glioma; Humans; Models, Biological; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Statistics, Nonparametric; Support Vector Machine; Surgery, Computer-Assisted

2011
Fluorescence photobleaching of ALA and ALA-heptyl ester induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: a comparison of two light sources and different illumination schemes.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2011, Volume: 30, Issue:3

    Topics: Aminolevulinic Acid; Animals; Esters; Female; Fluorescence; Lasers; Light; Mice; Mice, Hairless; Mice, Inbred BALB C; Models, Animal; Oxygen; Photobleaching; Photochemotherapy; Protoporphyrins; Skin; Time Factors

2011
Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain.
    Journal of biomedical optics, 2011, Volume: 16, Issue:12

    Topics: Absorption; Aminolevulinic Acid; Diagnostic Imaging; Humans; Image Processing, Computer-Assisted; Light; Monte Carlo Method; Phantoms, Imaging; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Scattering, Radiation; Skin; Spectrometry, Fluorescence

2011
Photosensitizer-loaded dendrimer-modified multi-walled carbon nanotubes for photodynamic therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2011, Nov-30, Volume: 152 Suppl 1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Dendrimers; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Humans; Microscopy, Fluorescence; Nanotubes, Carbon; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Solubility; Stomach Neoplasms; Technology, Pharmaceutical; Time Factors

2011
Comparison of noninvasive photodynamic therapy dosimetry methods using a dynamic model of ALA-PDT of human skin.
    Physics in medicine and biology, 2012, Feb-07, Volume: 57, Issue:3

    Topics: Aminolevulinic Acid; Computer Simulation; Humans; Models, Statistical; Optics and Photonics; Oxygen Consumption; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiography; Radiometry; Singlet Oxygen; Skin; Skin Neoplasms; Spectrometry, Fluorescence

2012
Protoporphyrin IX-dependent photodynamic production of endogenous ROS stimulates cell proliferation.
    European journal of cell biology, 2012, Volume: 91, Issue:3

    Topics: Aminolevulinic Acid; Cell Cycle; Cell Proliferation; Humans; Keratinocytes; NADPH Oxidase 1; NADPH Oxidases; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; src-Family Kinases; Tumor Cells, Cultured

2012
Porphyrin biodistribution in UV-exposed murine skin after methyl- and hexyl-aminolevulinate incubation.
    Experimental dermatology, 2012, Volume: 21, Issue:4

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biological Availability; Female; Humans; Mice; Mice, Hairless; Microscopy, Fluorescence; Models, Animal; Photochemotherapy; Photosensitizing Agents; Porphyrins; Precancerous Conditions; Protoporphyrins; Skin; Skin Neoplasms; Tissue Distribution; Ultraviolet Rays

2012
Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro.
    Oncology reports, 2012, Volume: 27, Issue:6

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Protoporphyrins; Radiation-Sensitizing Agents; Radiation, Ionizing; Rats; Reactive Oxygen Species

2012
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
    Journal of neuro-oncology, 2012, Volume: 108, Issue:3

    Topics: Aminolevulinic Acid; Anticonvulsants; Fluorescence; Glioma; Glutathione; Humans; Levetiracetam; Membrane Potential, Mitochondrial; Phenytoin; Photochemotherapy; Photosensitizing Agents; Piracetam; Protoporphyrins; Tumor Cells, Cultured

2012
Stem cell-based photodynamic therapy.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2012, Volume: 11, Issue:7

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Female; Fetal Blood; Imidazoles; Luciferases; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neural Stem Cells; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Plasmids; Protoporphyrins; Pyrazines; Rats; Stem Cell Transplantation; Stem Cells; Transfection

2012
5-aminolevulinic acid-incorporated poly(vinyl alcohol) nanofiber-coated metal stent for application in photodynamic therapy.
    International journal of nanomedicine, 2012, Volume: 7

    Topics: Aminolevulinic Acid; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Survival; Cholangiocarcinoma; Drug-Eluting Stents; Humans; Microscopy, Electron, Scanning; Nanofibers; Nanomedicine; Photochemotherapy; Photosensitizing Agents; Polyvinyl Alcohol; Protoporphyrins

2012
Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy.
    International journal of nanomedicine, 2012, Volume: 7

    Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; Colonic Neoplasms; Flow Cytometry; HCT116 Cells; HEK293 Cells; Histidine; Humans; Hydrogen-Ion Concentration; Models, Molecular; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins

2012
Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.
    Annals of surgical oncology, 2013, Volume: 20, Issue:13

    Topics: Aminolevulinic Acid; Apoptosis; ATP-Binding Cassette Transporters; Blotting, Western; Brain; Brain Neoplasms; Case-Control Studies; Cell Proliferation; Fluorescence; Glioma; Humans; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured

2013
Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 30, Issue:2

    Topics: Aminolevulinic Acid; Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cytochromes c; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Protoporphyrins; Reactive Oxygen Species; Tongue Neoplasms; Transplantation, Heterologous; Ultrasonic Therapy

2012
Validation of the protoporphyrin IX-triplet state lifetime technique for mitochondrial oxygen measurements in the skin.
    Optics letters, 2012, Jul-01, Volume: 37, Issue:13

    Topics: Aminolevulinic Acid; Animals; Humans; Male; Mitochondria; Optical Phenomena; Oxygen; Protoporphyrins; Rats; Skin; Spectrometry, Fluorescence

2012
Comparison of the uptake of 5-aminolevulinic acid and its methyl ester in keratinocytes and skin.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:10

    Topics: Amino Acids; Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; GABA Plasma Membrane Transport Proteins; Humans; Keratinocytes; Male; Mice; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Absorption

2012
Weather conditions and daylight-mediated photodynamic therapy: protoporphyrin IX-weighted daylight doses measured in six geographical locations.
    The British journal of dermatology, 2013, Volume: 168, Issue:1

    Topics: Aminolevulinic Acid; Dose-Response Relationship, Radiation; Europe; Geography, Medical; Humans; Israel; Keratosis, Actinic; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiometry; Residence Characteristics; Seasons; Skin Neoplasms; Sunlight; Temperature; Ultraviolet Rays; Weather

2013
Differential cytotoxic response in keloid fibroblasts exposed to photodynamic therapy is dependent on photosensitiser precursor, fluence and location of fibroblasts within the lesion.
    Archives of dermatological research, 2012, Volume: 304, Issue:7

    Topics: Adult; Aminolevulinic Acid; Apoptosis; Cell Differentiation; Cells, Cultured; Cellular Senescence; Female; Fibroblasts; Humans; Keloid; Male; Middle Aged; Photochemotherapy; Protoporphyrins; Reactive Oxygen Species; Skin

2012
Automatic laser scanning ablation system for high-precision treatment of brain tumors.
    Lasers in medical science, 2013, Volume: 28, Issue:3

    Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Equipment Design; Glioma; Humans; Laser Therapy; Models, Animal; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Swine

2013
Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown.
    Journal of neuropathology and experimental neurology, 2012, Volume: 71, Issue:9

    Topics: Aminolevulinic Acid; Blood-Brain Barrier; Brain Neoplasms; Craniotomy; Creatinine; Female; Gadolinium; Glioma; Humans; Magnetic Resonance Imaging; Male; Mass Spectrometry; Microvessels; Photosensitizing Agents; Platelet Endothelial Cell Adhesion Molecule-1; Protoporphyrins; Statistics as Topic; Statistics, Nonparametric

2012
Protoporphyrin IX formation and photobleaching in different layers of normal human skin: methyl- and hexylaminolevulinate and different light sources.
    Experimental dermatology, 2012, Volume: 21, Issue:10

    Topics: Adolescent; Adult; Aminolevulinic Acid; Dermis; Epidermis; Humans; Lasers, Dye; Light; Microscopy, Fluorescence; Middle Aged; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Young Adult

2012
The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells.
    Urology, 2012, Volume: 80, Issue:6

    Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Chelating Agents; Ethylenediamines; Humans; Male; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; X-Linked Inhibitor of Apoptosis Protein; Zinc

2012
In vitro investigation of efficient photodynamic therapy using a nonviral vector; hemagglutinating virus of Japan envelope.
    Journal of biomedical optics, 2012, Volume: 17, Issue:7

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Humans; Lung Neoplasms; Melanoma, Experimental; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sendai virus; Spectrometry, Fluorescence; Viral Envelope Proteins

2012
Modelling fluorescence in clinical photodynamic therapy.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, Volume: 12, Issue:1

    Topics: Aminolevulinic Acid; Humans; Models, Theoretical; Monte Carlo Method; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiometry; Skin Diseases; Skin Neoplasms; Spectrometry, Fluorescence

2013
Factors implicated in the assessment of aminolevulinic acid-induced protoporphyrin IX fluorescence.
    Biochimica et biophysica acta, 2013, Volume: 1830, Issue:3

    Topics: Aminolevulinic Acid; Cell Communication; Cell Line, Tumor; Coculture Techniques; Collagen; Flow Cytometry; Fluorescence; Humans; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria; Neoplasms; Organ Specificity; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

2013
Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Adenosine; Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line, Tumor; Diketopiperazines; Doxorubicin; Endoplasmic Reticulum; Ferrochelatase; Gene Expression; Glycosylation; Golgi Apparatus; HEK293 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Mitochondria; Neoplasm Proteins; Peptide Transporter 1; Protein Transport; Protoporphyrins; Recombinant Fusion Proteins; Symporters; U937 Cells

2012
Real-time, in vivo measurement of tissular pO2 through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy.
    Journal of biomedical optics, 2012, Volume: 17, Issue:11

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Chick Embryo; Chorioallantoic Membrane; Fluorescence; Kinetics; Optical Phenomena; Oxygen; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tissue Distribution

2012
[Intraoperative fluorescent visualization and laser spectrosopy in intrinsic brain tumor surgery].
    Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko, 2012, Volume: 76, Issue:5

    Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Humans; Male; Middle Aged; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

2012
In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cells.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Aminolevulinic Acid; Anthracenes; Cell Line, Tumor; Cerebellar Neoplasms; Humans; Medulloblastoma; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2012
Effects of 5-aminolevulinic acid-mediated sonodynamic therapy on macrophages.
    International journal of nanomedicine, 2013, Volume: 8

    Topics: Aminolevulinic Acid; Analysis of Variance; Cell Death; Cell Line; Cell Survival; Flow Cytometry; Humans; Macrophages; Membrane Potential, Mitochondrial; Protoporphyrins; Reactive Oxygen Species; Ultrasonic Therapy; Ultrasonics

2013
Aminolevulinic acid derivatives-based photodynamic therapy in human intra- and extrahepatic cholangiocarcinoma cells.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2013, Volume: 85, Issue:3 Pt A

    Topics: Aminolevulinic Acid; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinoma; Dose-Response Relationship, Drug; Humans; Peptide Transporter 1; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Symporters

2013
Photodynamic detection and management of intraperitoneal spreading of primary peritoneal papillary serous carcinoma in a man: report of a case.
    Surgery today, 2014, Volume: 44, Issue:2

    Topics: Administration, Oral; Aminolevulinic Acid; Combined Modality Therapy; Cystadenocarcinoma, Papillary; Cystadenocarcinoma, Serous; Humans; Intraoperative Period; Male; Middle Aged; Peritoneal Neoplasms; Peritoneum; Photochemical Processes; Photosensitizing Agents; Protoporphyrins

2014
Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Drug Combinations; Drug Synergism; Humans; Image Enhancement; Microscopy, Fluorescence; Neoplasms, Experimental; Photosensitizing Agents; Propyl Gallate; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity

2013
Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma.
    Cancer science, 2013, Volume: 104, Issue:6

    Topics: Aminolevulinic Acid; Angiogenesis Inhibitors; Animals; Apoptosis; Carcinoma, Transitional Cell; Cell Line; Deferoxamine; Enzyme Inhibitors; Ferrochelatase; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2013
5-aminolevulinic acid-incorporated nanoparticles of methoxy poly(ethylene glycol)-chitosan copolymer for photodynamic therapy.
    International journal of nanomedicine, 2013, Volume: 8

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Humans; Nanoparticles; Particle Size; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Protoporphyrins

2013
Effects of 5-aminolevulinic acid-mediated photodynamic therapy on antibiotic-resistant staphylococcal biofilm: an in vitro study.
    The Journal of surgical research, 2013, Volume: 184, Issue:2

    Topics: Aminolevulinic Acid; Animals; Biofilms; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Bacterial; In Vitro Techniques; Methicillin-Resistant Staphylococcus aureus; Microscopy, Electron, Scanning; Photochemotherapy; Protoporphyrins; Staphylococcus epidermidis; Treatment Outcome

2013
Antitumor effect of combination of hyperthermotherapy and 5-aminolevulinic acid (ALA).
    Anticancer research, 2013, Volume: 33, Issue:7

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Lewis Lung; Combined Modality Therapy; Female; Hyperthermia, Induced; Light; Lung Neoplasms; Mice; Mice, Inbred C57BL; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2013
Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.
    Acta medica Okayama, 2013, Volume: 67, Issue:3

    Topics: Amino Acid Chloromethyl Ketones; Aminolevulinic Acid; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood Proteins; Carcinoma, Squamous Cell; Caspase Inhibitors; Cell Line, Tumor; Deferoxamine; Ferrochelatase; Gene Silencing; Humans; Lipid Peroxidation; Mouth Neoplasms; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Siderophores

2013
Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX.
    Bioorganic & medicinal chemistry letters, 2013, Aug-15, Volume: 23, Issue:16

    Topics: Aminolevulinic Acid; Binding, Competitive; Carbon Radioisotopes; Cells, Cultured; Chromatography, High Pressure Liquid; Humans; Molecular Structure; Neoplasms; Photosensitizing Agents; Positron-Emission Tomography; Protoporphyrins; Time Factors

2013
Cisplatin enhances the efficacy of 5-aminolevulinic acid mediated photodynamic therapy in human head and neck squamous cell carcinoma.
    General physiology and biophysics, 2014, Volume: 33, Issue:1

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Synergism; Female; Head and Neck Neoplasms; Humans; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tetrazolium Salts; Thiazoles; Xenograft Model Antitumor Assays

2014
Detection of metastatic lymph nodes using 5-aminolevulinic acid in patients with gastric cancer.
    Annals of surgical oncology, 2013, Volume: 20, Issue:11

    Topics: Aminolevulinic Acid; Fluorescence; Humans; Lymph Nodes; Lymphatic Metastasis; Neoplasm Staging; Photosensitizing Agents; Prognosis; Protoporphyrins; ROC Curve; Stomach Neoplasms

2013
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
    Photomedicine and laser surgery, 2013, Volume: 31, Issue:9

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; Rats; Tumor Cells, Cultured

2013
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.
    Neurosurgery, 2014, Volume: 10 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Analysis of Variance; Cluster Analysis; Female; Fluorescence; Fluorescent Dyes; Humans; Light; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neoplasm Staging; Neurosurgical Procedures; Prospective Studies; Protoporphyrins; ROC Curve; Sensitivity and Specificity

2014
Topical hexylaminolevulinate and aminolevulinic acid photodynamic therapy: complete arteriole vasoconstriction occurs frequently and depends on protoporphyrin IX concentration in vessel wall.
    Journal of photochemistry and photobiology. B, Biology, 2013, Sep-05, Volume: 126

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Arterioles; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Vasoconstriction

2013
Differential sensitivity in cell lines to photodynamic therapy in combination with ABCG2 inhibition.
    Journal of photochemistry and photobiology. B, Biology, 2013, Sep-05, Volume: 126

    Topics: Adenosine; Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Diketopiperazines; Esters; Extracellular Space; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Humans; Intracellular Space; Isomerism; Neoplasm Proteins; Photochemotherapy; Protoporphyrins

2013
Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma.
    Journal of photochemistry and photobiology. B, Biology, 2013, Oct-05, Volume: 127

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Glioma; Heme; Humans; Intracellular Space; Oxides; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar

2013
Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:3

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; Metabolic Clearance Rate; Neoplasm Proteins; Peptide Transporter 1; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction; Symporters; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2013
Efficiency of 5-ALA mediated photodynamic therapy on hypoxic prostate cancer: a preclinical study on the Dunning R3327-AT2 rat tumor model.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Hypoxia; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Therapy, Combination; Male; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Rats; Treatment Outcome

2013
Cadherin 13 overexpression as an important factor related to the absence of tumor fluorescence in 5-aminolevulinic acid-guided resection of glioma.
    Journal of neurosurgery, 2013, Volume: 119, Issue:5

    Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Cadherins; Cell Line, Tumor; Fluorescence; Gene Expression; Glioblastoma; Humans; Metabolic Networks and Pathways; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted

2013
Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma.
    Acta oncologica (Stockholm, Sweden), 2014, Volume: 53, Issue:3

    Topics: Aminolevulinic Acid; Astrocytes; Brain Neoplasms; Calcitriol; Cell Line, Tumor; Cell Survival; Enzymes; Fluorescence; Gene Expression Regulation, Neoplastic; Glioma; Humans; Molecular Imaging; Photochemotherapy; Protoporphyrins

2014
Correlation between protoporphyrin IX fluorescence intensity, photobleaching, pain and clinical outcome of actinic keratosis treated by photodynamic therapy.
    Dermatology (Basel, Switzerland), 2013, Volume: 227, Issue:3

    Topics: Aged; Aminolevulinic Acid; Fluorescence; Humans; Keratosis, Actinic; Middle Aged; Pain; Pain Measurement; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment Outcome

2013
Accumulation and elimination of photosens and protoporphyrin IX by different types of mesenchymal cells.
    Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:4

    Topics: Aminolevulinic Acid; Cell Survival; Cells, Cultured; Endothelial Cells; Humans; Indoles; Kinetics; Macrophages; Mesenchymal Stem Cells; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2013
Comparative kinetics of damage to the plasma and mitochondrial membranes by intra-cellularly synthesized and externally-provided photosensitizers using multi-color FACS.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2014, Volume: 13, Issue:1

    Topics: Aminolevulinic Acid; Anthracyclines; Benzimidazoles; Carbocyanines; Cell Line, Tumor; Cell Membrane; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Light; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Neurons; Photosensitizing Agents; Protoporphyrins

2014
5-Aminolevulinic acid induced fluorescence is a powerful intraoperative marker for precise histopathological grading of gliomas with non-significant contrast-enhancement.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Monitoring, Intraoperative; Prospective Studies; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity; Young Adult

2013
The inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic action for prostate cancer.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:4

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Chloroquine; Deferoxamine; Drug Synergism; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins

2013
Clearance mechanism of protoporphyrin IX from mouse skin after application of 5-aminolevulinic acid.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:4

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; In Vitro Techniques; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Skin; Tissue Distribution

2013
Detection of lymph node metastases in human colorectal cancer by using 5-aminolevulinic acid-induced protoporphyrin IX fluorescence with spectral unmixing.
    International journal of molecular sciences, 2013, Nov-21, Volume: 14, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Colorectal Neoplasms; Female; Fluorescence; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Protoporphyrins

2013
Optical glucose analogs of aminolevulinic acid for fluorescence-guided tumor resection and photodynamic therapy.
    Molecular imaging and biology, 2014, Volume: 16, Issue:4

    Topics: 4-Chloro-7-nitrobenzofurazan; Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glucosamine; Glucose; Humans; Male; Mesocricetus; Mice, SCID; Phloretin; Photochemotherapy; Protoporphyrins; Rats; Surgery, Computer-Assisted

2014
[Photodynamic diagnosis and preoperative chemotherapy for biliary tract cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:12

    Topics: Aminolevulinic Acid; Biliary Tract Neoplasms; Cell Line, Tumor; Humans; Microscopy, Electron, Scanning; Photochemical Processes; Protoporphyrins; Spectrometry, Fluorescence

2013
Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience.
    World journal of surgery, 2014, Volume: 38, Issue:7

    Topics: Aged; Aminolevulinic Acid; Anastomotic Leak; Carcinoma, Hepatocellular; Color; Colorectal Neoplasms; Female; Fluorescence; Hepatectomy; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm, Residual; Operative Time; Photosensitizing Agents; Protoporphyrins

2014
Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema.
    Journal of biomedical optics, 2014, Volume: 19, Issue:2

    Topics: Adult; Aminolevulinic Acid; Erythema; Female; Humans; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen; Skin; Spectrometry, Fluorescence

2014
Design and validation of a fiber optic point probe instrument for therapy guidance and monitoring.
    Journal of biomedical optics, 2014, Volume: 19, Issue:7

    Topics: Aminolevulinic Acid; Animals; Calibration; Carcinoma, Squamous Cell; Equipment Design; Fiber Optic Technology; Humans; Least-Squares Analysis; Light; Mice; Neoplasms; Optical Fibers; Phantoms, Imaging; Photochemotherapy; Protoporphyrins; Reproducibility of Results; Scattering, Radiation; Skin Neoplasms; Spectrophotometry; Support Vector Machine

2014
A novel photodynamic therapy for drug-resistant prostate cancer cells using porphyrus envelope as a novel photosensitizer.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Drug Delivery Systems; Humans; Male; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Sendai virus

2014
The effect of fluence rate on the acute response of vessel diameter and red blood cell velocity during topical 5-aminolevulinic acid photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Blood Flow Velocity; Dose-Response Relationship, Radiation; Erythrocytes; Mice; Mice, Nude; Photochemotherapy; Protoporphyrins; Radiation Dosage; Skin; Vasoconstriction

2014
Optimization of photodynamic therapy using negative pressure.
    Photomedicine and laser surgery, 2014, Volume: 32, Issue:5

    Topics: Aminolevulinic Acid; Humans; Negative-Pressure Wound Therapy; Photochemotherapy; Protoporphyrins; Skin Cream

2014
Identification of pathological and normal parathyroid tissue by fluorescent labeling with 5-aminolevulinic acid during endocrine neck surgery.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2014, Volume: 81, Issue:2

    Topics: Adult; Aged; Aminolevulinic Acid; Female; Humans; Male; Middle Aged; Neck; Parathyroid Glands; Parathyroidectomy; Protoporphyrins; Thoracic Surgery, Video-Assisted; Thyroid Gland; Thyroidectomy

2014
Femtosecond laser induced photodynamic therapy on 5-ALA treated SKMEL-30 cells: an efficient theranostic strategy to combat melanoma.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:5

    Topics: Aged; Aminolevulinic Acid; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Fluorescence; Humans; Lasers; Male; Melanoma; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Time Factors

2014
Exposure of mice to chronic hypoxia attenuates pulmonary arterial contractile responses to acute hypoxia by increases in extracellular hydrogen peroxide.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2014, Aug-15, Volume: 307, Issue:4

    Topics: Acute Disease; Aminolevulinic Acid; Animals; Antihypertensive Agents; Aorta; Cell Adhesion Molecules; Chronic Disease; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Familial Primary Pulmonary Hypertension; Hydrogen Peroxide; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Phosphoproteins; Phosphorylation; Protoporphyrins; Pulmonary Artery; Superoxide Dismutase; Superoxides; Time Factors; Up-Regulation; Vasoconstriction

2014
[Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases].
    No shinkei geka. Neurological surgery, 2014, Volume: 42, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Count; Cell Line, Tumor; Female; Glioma; Humans; Male; Photosensitizing Agents; Protoporphyrins; Rats

2014
Physiological oxygen concentration alters glioma cell malignancy and responsiveness to photodynamic therapy in vitro.
    Neurological research, 2014, Volume: 36, Issue:11

    Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents, Phytogenic; Camptothecin; Caspase 3; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Survival; Extracellular Matrix Proteins; Female; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Oxygen; Photochemotherapy; Protoporphyrins

2014
Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas.
    Acta neurochirurgica, 2014, Volume: 156, Issue:10

    Topics: Adult; Aminolevulinic Acid; Female; Fluorescence; Humans; Meningeal Neoplasms; Meningioma; Photosensitizing Agents; Protoporphyrins; Young Adult

2014
Singlet oxygen and ROS in a new light: low-dose subcellular photodynamic treatment enhances proliferation at the single cell level.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2014, Volume: 13, Issue:9

    Topics: Aminolevulinic Acid; Apoptosis; Cell Proliferation; HeLa Cells; Humans; Lasers; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Singlet Oxygen

2014
Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos.
    Anticancer research, 2014, Volume: 34, Issue:8

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chick Embryo; Metalloporphyrins; Mice; Neoplasms, Experimental; Protoporphyrins; Ultrasonic Therapy

2014
Photodynamic diagnosis of shed prostate cancer cells in voided urine treated with 5-aminolevulinic acid.
    BMC urology, 2014, Aug-03, Volume: 14

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biomarkers, Tumor; Feasibility Studies; Humans; Male; Microscopy, Fluorescence; Middle Aged; Photosensitizing Agents; Prospective Studies; Prostatic Neoplasms; Protoporphyrins; Sensitivity and Specificity; Urine

2014
Real-time analysis of endogenous protoporphyrin IX fluorescence from δ-aminolevulinic acid and its derivatives reveals distinct time- and dose-dependent characteristics in vitro.
    Journal of biomedical optics, 2014, Volume: 19, Issue:8

    Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Cell Survival; Computer Systems; Dose-Response Relationship, Drug; Humans; Neoplasms, Experimental; Photochemotherapy; Protoporphyrins; Radiation-Sensitizing Agents; Spectrometry, Fluorescence

2014
Preclinical characterization of 5-amino-4-oxo-[6-11C]hexanoic acid as an imaging probe to estimate protoporphyrin IX accumulation induced by exogenous aminolevulinic acid.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:10

    Topics: Aminocaproates; Aminolevulinic Acid; Animals; Cell Line, Tumor; Humans; Mice; Neoplasm Transplantation; Neoplasms; Positron-Emission Tomography; Protoporphyrins

2014
Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells.
    Biochimie, 2014, Volume: 106

    Topics: Adenosine Triphosphate; Aminolevulinic Acid; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Transport Complex I; Gene Expression; Hep G2 Cells; Humans; Ion Channels; Liver Neoplasms; Metalloporphyrins; Microscopy, Confocal; Mitochondria; Mitochondrial Proteins; Oxidants; Oxygen Consumption; Protoporphyrins; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Transcription Factors; Uncoupling Protein 2

2014
Assessment of ALA-induced PpIX production in porcine skin pretreated with microneedles.
    Journal of biophotonics, 2015, Volume: 8, Issue:9

    Topics: Aminolevulinic Acid; Animals; Kinetics; Male; Needles; Prodrugs; Protoporphyrins; Skin; Sus scrofa

2015
5-Aminolevulinic acid enhances cell death under thermal stress in certain cancer cell lines.
    Bioscience, biotechnology, and biochemistry, 2015, Volume: 79, Issue:3

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Death; Cell Line, Tumor; Ferrochelatase; Frataxin; Gene Expression Regulation, Neoplastic; Heat-Shock Response; Humans; Intracellular Space; Iron-Binding Proteins; Neoplasm Proteins; Protoporphyrins; Reactive Oxygen Species

2015
Effects of bisphenol A on chlorophyll synthesis in soybean seedlings.
    Environmental science and pollution research international, 2015, Volume: 22, Issue:8

    Topics: Aminolevulinic Acid; Analysis of Variance; Benzhydryl Compounds; Biosynthetic Pathways; Chlorophyll; Environmental Pollutants; Glycine max; Hydroxymethylbilane Synthase; Phenols; Photosynthesis; Plant Leaves; Porphobilinogen Synthase; Protoporphyrinogen Oxidase; Protoporphyrins; Seedlings; Spectrometry, Fluorescence; Uroporphyrinogen Decarboxylase; Uroporphyrinogen III Synthetase

2015
Calcipotriol pretreatment enhances methyl aminolevulinate-induced protoporphyrin IX: an in vivo study in hairless mice.
    Photodermatology, photoimmunology & photomedicine, 2015, Volume: 31, Issue:1

    Topics: Aminolevulinic Acid; Animals; Calcitriol; Dermatologic Agents; Female; Mice; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Skin

2015
Cutaneous mitochondrial respirometry: non-invasive monitoring of mitochondrial function.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:4

    Topics: Aminolevulinic Acid; Animals; Blood Gas Monitoring, Transcutaneous; Endotoxemia; Equipment Design; Healthy Volunteers; Heme; Humans; Lipopolysaccharides; Male; Mitochondria; Monitoring, Physiologic; Oxygen; Oxygen Consumption; Protoporphyrins; Rats; Rats, Wistar; Skin

2015
5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro.
    Oncology reports, 2015, Volume: 33, Issue:2

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Cytoplasm; Glioma; Humans; In Vitro Techniques; Photosensitizing Agents; Protoporphyrins; Rats; Reactive Oxygen Species; Time Factors; X-Rays

2015
5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.
    Molecular medicine reports, 2015, Volume: 11, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytotoxicity, Immunologic; Disease Models, Animal; Glioma; Male; Necrosis; Photochemotherapy; Protoporphyrins; Radiation Dosage; Radiation-Sensitizing Agents; Radiation, Ionizing; Rats; Tumor Burden

2015
Induction of protoporphyrin IX in patient-derived synoviocytes, cartilage explants and chondrons after application of 5-aminolevulinic acid or its methyl ester.
    Journal of photochemistry and photobiology. B, Biology, 2014, Volume: 141

    Topics: Aminolevulinic Acid; Arthritis, Rheumatoid; Cartilage; Chondrocytes; Humans; Osteoarthritis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Synovial Fluid

2014
Multi-channel LED light source for fluorescent agent aided minimally invasive surgery.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2014, Volume: 2014

    Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Indocyanine Green; Light; Minimally Invasive Surgical Procedures; Neoplasms; Optical Imaging; Photosensitizing Agents; Protoporphyrins; Semiconductors

2014
Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cell Line, Tumor; Female; Humans; Male; Middle Aged; Neoplasm Grading; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrophotometry; Urinary Bladder Neoplasms

2015
Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis.
    The Analyst, 2015, Mar-21, Volume: 140, Issue:6

    Topics: Aminolevulinic Acid; Animals; Aorta; Atherosclerosis; Fluorescence; Gold; Male; Nanoparticles; Photosensitizing Agents; Polyethylene Glycols; Protoporphyrins; Rabbits

2015
5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett's esophagus cellular models.
    Journal of biomedical optics, 2015, Volume: 20, Issue:2

    Topics: Aminolevulinic Acid; Barrett Esophagus; Cell Line, Tumor; Cell Survival; Humans; Intracellular Space; Models, Biological; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2015
Multidimensional visualization of healthy and sensitized rabbit knee tissues by means of confocal microscopy.
    Journal of biomedical optics, 2015, Volume: 20, Issue:5

    Topics: Aminolevulinic Acid; Animals; Cartilage; Chinchilla; Eosine Yellowish-(YS); Hematoxylin; Hindlimb; Joints; Male; Microscopy, Confocal; Microscopy, Fluorescence; Photosensitizing Agents; Porphyrins; Protoporphyrins; Rabbits; Spectrometry, Fluorescence; Synovial Membrane

2015
5-Aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett's esophagus cellular models.
    Journal of biomedical optics, 2015, Volume: 20, Issue:3

    Topics: Adenocarcinoma; Algorithms; Aminolevulinic Acid; Barrett Esophagus; Biomarkers; Esophageal Neoplasms; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Photosensitizing Agents; Pilot Projects; Precancerous Conditions; Protoporphyrins; Sensitivity and Specificity

2015
Correlation between treatment time, photobleaching, inflammation and pain after photodynamic therapy with methyl aminolevulinate on tape-stripped skin in healthy volunteers.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2015, Volume: 14, Issue:5

    Topics: Adult; Aminolevulinic Acid; Erythema; Fluorescence; Forearm; Humans; Inflammation; Male; Middle Aged; Pain; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Pigmentation; Time Factors; White People; Young Adult

2015
Low dose 5-aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:2

    Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Dose-Response Relationship, Drug; Female; Fluorescence; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence

2015
The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Aminolevulinic Acid; Cation Transport Proteins; Cell Line, Tumor; Heme; Humans; Iron; MCF-7 Cells; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity

2015
Monte Carlo modelling of daylight activated photodynamic therapy.
    Physics in medicine and biology, 2015, May-21, Volume: 60, Issue:10

    Topics: Algorithms; Aminolevulinic Acid; Humans; Light; Monte Carlo Method; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation Dosage; Skin

2015
Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED).
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:3

    Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Glioblastoma; Humans; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Survival Analysis; Time Factors

2015
Effect of cell cycle phase on the sensitivity of SAS cells to sonodynamic therapy using low-intensity ultrasound combined with 5-aminolevulinic acid in vitro.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Aminolevulinic Acid; Biotransformation; Caspase 3; Cell Cycle; Cell Line, Tumor; Cyclin A; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Protoporphyrins; Radiation Tolerance; Signal Transduction; Tongue; Ultrasonic Therapy; Ultrasonic Waves

2015
Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:9

    Topics: Aminolevulinic Acid; Caco-2 Cells; Cell Line, Tumor; Heme; Humans; K562 Cells; Kinetics; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; U937 Cells

2015
Potential Molecular Mechanisms Involved in 5-Aminolevulinic Acid-Based Photodynamic Therapy against Human Hypertrophic Scars.
    Plastic and reconstructive surgery, 2015, Volume: 136, Issue:4

    Topics: Aminolevulinic Acid; Apoptosis; Biomarkers; Blotting, Western; Cell Survival; Cells, Cultured; Cicatrix, Hypertrophic; Fibroblasts; Flow Cytometry; Humans; In Vitro Techniques; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Real-Time Polymerase Chain Reaction

2015
Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery.
    Journal of neurosurgery, 2015, Volume: 123, Issue:3

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Male; Middle Aged; Neuronavigation; Photosensitizing Agents; Protoporphyrins

2015
Deconvoluting heme biosynthesis to target blood-stage malaria parasites.
    eLife, 2015, Jul-14, Volume: 4

    Topics: Aminolevulinic Acid; Artemisinins; Biosynthetic Pathways; Erythrocytes; Heme; Humans; Lactones; Photosensitizing Agents; Plasmodium falciparum; Protoporphyrins; Reactive Oxygen Species

2015
Induction of apoptosis in HPV16 E7 transfected human keratinocyte by ALA-mediated photodynamic therapy.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 13

    Topics: Aminolevulinic Acid; Apoptosis; Cell Line; Humans; Keratinocytes; Light; Papillomavirus E7 Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Transfection; Treatment Outcome

2016
Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 13

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cells, Cultured; Cystoscopy; Ferrochelatase; Humans; Microscopy, Fluorescence; Molecular Imaging; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms

2016
Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.
    Biochemistry, 2015, Sep-15, Volume: 54, Issue:36

    Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Enzyme Stability; Escherichia coli; Genetic Diseases, X-Linked; HeLa Cells; Hot Temperature; Humans; K562 Cells; Kinetics; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Protoporphyria, Erythropoietic; Protoporphyrins; Thermodynamics

2015
Immobilization of ALA-Zn(II) Coordination Polymer Pro-photosensitizers on Magnetite Colloidal Supraparticles for Target Photodynamic Therapy of Bladder Cancer.
    Small (Weinheim an der Bergstrasse, Germany), 2015, Dec-16, Volume: 11, Issue:47

    Topics: Aminolevulinic Acid; Blotting, Western; Cell Death; Cell Line, Tumor; Colloids; Ferrosoferric Oxide; Humans; Microspheres; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Polymers; Powders; Protoporphyrins; Temperature; Thermogravimetry; Urinary Bladder Neoplasms; X-Linked Inhibitor of Apoptosis Protein; X-Ray Diffraction; Zinc

2015
Epidermal penetration and protoporphyrin IX formation of two different 5-aminolevulinic acid formulations in ex vivo human skin.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 14

    Topics: Adult; Aminolevulinic Acid; Epidermis; Female; Humans; Male; Middle Aged; Models, Biological; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2016
Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis.
    The Journal of biological chemistry, 2016, Jan-22, Volume: 291, Issue:4

    Topics: Aminolevulinic Acid; Animals; Cell Death; Heme; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Mitochondria; Protoporphyrins; Receptors, GABA

2016
Fluorescence characteristics of human Barrett tissue specimens grafted on chick chorioallantoic membrane.
    Lasers in medical science, 2016, Volume: 31, Issue:1

    Topics: Aminolevulinic Acid; Animals; Barrett Esophagus; Biopsy; Chickens; Chorioallantoic Membrane; Humans; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

2016
Dexamethasone alone and in combination with desipramine, phenytoin, valproic acid or levetiracetam interferes with 5-ALA-mediated PpIX production and cellular retention in glioblastoma cells.
    Journal of neuro-oncology, 2016, Volume: 127, Issue:1

    Topics: Aminolevulinic Acid; Anti-Inflammatory Agents; Anticonvulsants; Desipramine; Dexamethasone; Drug Therapy, Combination; Enzyme Inhibitors; Fluorescence; Glioblastoma; Humans; Levetiracetam; Phenytoin; Photosensitizing Agents; Piracetam; Protoporphyrins; Valproic Acid

2016
Skin tumor development after UV irradiation and photodynamic therapy is unaffected by short-term pretreatment with 5-fluorouracil, imiquimod and calcipotriol. An experimental hairless mouse study.
    Journal of photochemistry and photobiology. B, Biology, 2016, Volume: 154

    Topics: Aminolevulinic Acid; Aminoquinolines; Animals; Calcitriol; Carcinoma, Squamous Cell; Female; Fluorouracil; Imiquimod; Mice; Mice, Hairless; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Ultraviolet Rays

2016
Can basal cell carcinoma lateral border be determined by fluorescence diagnosis?: Verification by Mohs micrographic surgery.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 14

    Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Diagnostic Techniques, Surgical; Female; Fluorescence; Humans; Male; Middle Aged; Mohs Surgery; Protoporphyrins; Skin Neoplasms

2016
A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:5

    Topics: Aminolevulinic Acid; Animals; Deferoxamine; Disease Models, Animal; Genetic Predisposition to Disease; Larva; Liver; Mice; Photosensitizing Agents; Protein Aggregation, Pathological; Protoporphyria, Erythropoietic; Protoporphyrins; Siderophores; Stress, Physiological; Zebrafish

2016
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:8

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Hyperthermia, Induced; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Protoporphyrins; Reactive Oxygen Species; Ultrasonic Therapy; Xenograft Model Antitumor Assays

2016
Short-term chemical pretreatment cannot replace curettage in photodynamic therapy.
    Photodermatology, photoimmunology & photomedicine, 2016, Volume: 32, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Curettage; Dermatologic Agents; Drug Therapy, Combination; Female; Fluorescence; Healthy Volunteers; Humans; Keratolytic Agents; Male; Middle Aged; Ointments; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Salicylic Acid; Young Adult

2016
Light Fractionation Significantly Increases the Efficacy of Photodynamic Therapy Using BF-200 ALA in Normal Mouse Skin.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Aminolevulinic Acid; Animals; Animals, Outbred Strains; Dose Fractionation, Radiation; Drug Evaluation, Preclinical; Endothelial Cells; Female; Mice; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Sus scrofa

2016
Ablative fractional laser enhances MAL-induced PpIX accumulation: Impact of laser channel density, incubation time and drug concentration.
    Journal of photochemistry and photobiology. B, Biology, 2016, Volume: 159

    Topics: Adolescent; Adult; Aminolevulinic Acid; Humans; Lasers; Male; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Young Adult

2016
Highly sensitive fluorescence detection of metastatic lymph nodes of gastric cancer with photo-oxidation of protoporphyrin IX.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2016, Volume: 42, Issue:8

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cell Line, Tumor; Female; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Light; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Optical Imaging; Oxidation-Reduction; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Stomach Neoplasms

2016
Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions.
    Scientific reports, 2016, 05-05, Volume: 6

    Topics: Aminolevulinic Acid; Biotransformation; Cell Line, Tumor; Collagen; Colorectal Neoplasms; Flavins; Fluorescent Dyes; Humans; Image Processing, Computer-Assisted; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Optical Imaging; Protoporphyrins; Signal-To-Noise Ratio; Software

2016
eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy.
    Scientific reports, 2016, 05-06, Volume: 6

    Topics: Aminolevulinic Acid; Biological Availability; Cell Line; Gene Library; Hep G2 Cells; Humans; Neoplasms; Peptide Elongation Factor 1; Photochemotherapy; Photosensitizing Agents; Protein Binding; Protoporphyrins

2016
Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 05-11, Volume: 36, Issue:19

    Topics: Aminolevulinic Acid; Animals; Cells, Cultured; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Neuropeptides; Photochemotherapy; Photosensitizing Agents; Porphyrias; Protoporphyrins; Reactive Oxygen Species; Sensory Receptor Cells; Skin; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2016
Tumor reactive ringlet oxygen approach for Monte Carlo modeling of photodynamic therapy dosimetry.
    Journal of photochemistry and photobiology. B, Biology, 2016, Volume: 160

    Topics: Aminolevulinic Acid; Humans; Models, Theoretical; Monte Carlo Method; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen

2016
Tunable phosphatase-sensitive stable prodrugs of 5-aminolevulinic acid for tumor fluorescence photodetection.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, 08-10, Volume: 235

    Topics: Alkaline Phosphatase; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Fluorescence; Glioblastoma; Humans; Photochemotherapy; Prodrugs; Protoporphyrins; Spheroids, Cellular

2016
Plum-blossom needling promoted PpIX fluorescence intensity from 5-aminolevulinic acid in porcine skin model and patients with actnic keratosis.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 15

    Topics: Acupuncture Therapy; Aged; Aminolevulinic Acid; Animals; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Keratosis, Actinic; Male; Microscopy, Fluorescence; Middle Aged; Photosensitizing Agents; Protoporphyrins; Skin; Skin Absorption; Swine

2016
The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species.
    Redox biology, 2016, Volume: 9

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Histidine; Humans; Iron Chelating Agents; Metalloporphyrins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Pyridones; Reactive Oxygen Species

2016
Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer.
    British journal of cancer, 2016, 09-27, Volume: 115, Issue:7

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Female; Heme; Humans; Lasers, Semiconductor; Lighting; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Random Allocation; Siderophores; Skin Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays

2016
Human glioblastoma stem-like cells accumulate protoporphyrin IX when subjected to exogenous 5-aminolaevulinic acid, rendering them sensitive to photodynamic treatment.
    Journal of photochemistry and photobiology. B, Biology, 2016, Volume: 163

    Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Glioblastoma; Humans; Neoplastic Stem Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors

2016
Photodynamic Diagnosis of Hepatocellular Carcinoma Using 5-Aminolevulinic Acid.
    Anticancer research, 2016, Volume: 36, Issue:9

    Topics: Aged; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Embolization, Therapeutic; Female; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2016
Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells.
    Molecular neurobiology, 2017, Volume: 54, Issue:7

    Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Coproporphyrinogen Oxidase; Fluorescence; Glioma; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2017
Optimization and therapeutic effects of PDT mediated by ALA and MAL in the treatment of cutaneous malignant lesions: A comparative study.
    Journal of biophotonics, 2016, Volume: 9, Issue:11-12

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Female; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms

2016
Zwitterionic stealth peptide-capped 5-aminolevulinic acid prodrug nanoparticles for targeted photodynamic therapy.
    Journal of colloid and interface science, 2017, Jan-01, Volume: 485

    Topics: Amino Acid Sequence; Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Drug Liberation; Gold; Humans; Hydrogen-Ion Concentration; Light; Nanoparticles; Peptides; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins

2017
Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2016, Nov-02, Volume: 15, Issue:11

    Topics: Amines; Aminolevulinic Acid; Animals; Cell Membrane; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Photochemotherapy; Photosensitizing Agents; Picolinic Acids; Protoporphyrins; Zinc

2016
Multispectral autofluorescence imaging for detection of cervical lesions: A preclinical study.
    The journal of obstetrics and gynaecology research, 2016, Volume: 42, Issue:12

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Disease Models, Animal; Female; Human papillomavirus 16; Humans; Mice; Mice, Nude; Optical Imaging; Photochemotherapy; Protoporphyrins; Uterine Cervical Neoplasms

2016
Evaluation of Hydrogel Suppositories for Delivery of 5-Aminolevulinic Acid and Hematoporphyrin Monomethyl Ether to Rectal Tumors.
    Molecules (Basel, Switzerland), 2016, Oct-12, Volume: 21, Issue:10

    Topics: Administration, Intravenous; Administration, Topical; Aminolevulinic Acid; Animals; Cell Line, Tumor; Hematoporphyrins; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rectal Neoplasms; Suppositories; Xenograft Model Antitumor Assays

2016
A consensus on the use of daylight photodynamic therapy in the UK.
    The Journal of dermatological treatment, 2017, Volume: 28, Issue:4

    Topics: Aminolevulinic Acid; Consensus; Humans; Keratosis, Actinic; Light; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; United Kingdom

2017
Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters.
    Journal of neuro-oncology, 2017, Volume: 131, Issue:2

    Topics: Adult; Aminolevulinic Acid; Female; Glioma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mutation; Postoperative Care; Preoperative Care; Protoporphyrins; Retrospective Studies; Sensitivity and Specificity; Supratentorial Neoplasms; Tumor Suppressor Protein p53

2017
Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy.
    Scientific reports, 2016, 11-18, Volume: 6

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Male; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Spheroids, Cellular

2016
Sonodynamic Therapy Inhibits Fibrogenesis in Rat Cardiac Fibroblasts Induced by TGF-β1.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 40, Issue:3-4

    Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Proliferation; Cell Survival; Collagen; Fibroblasts; Fibrosis; Glycogen Synthase Kinase 3 beta; Intracellular Space; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Protoporphyrins; Rats, Sprague-Dawley; Smad3 Protein; Transforming Growth Factor beta1; Ultrasonics

2016
Lack of effect of selected sunscreens applied on ex vivo human skin for 5-methyl-aminolevulinic acid penetration and protoporphyrin IX photoactivation.
    Photodiagnosis and photodynamic therapy, 2017, Volume: 17

    Topics: Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Absorption; Sunscreening Agents

2017
A monitor for Cellular Oxygen METabolism (COMET): monitoring tissue oxygenation at the mitochondrial level.
    Journal of clinical monitoring and computing, 2017, Volume: 31, Issue:6

    Topics: Aminolevulinic Acid; Biocompatible Materials; Equipment Design; Humans; Lasers; Microcirculation; Mitochondria; Monitoring, Ambulatory; Oxygen; Oxygen Consumption; Protoporphyrins; Signal Processing, Computer-Assisted; Skin

2017
Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model.
    Journal of biomedical optics, 2016, 12-01, Volume: 21, Issue:12

    Topics: Aminolevulinic Acid; Glucose; Models, Biological; Oxygen; Protoporphyrins; Saccharomyces cerevisiae; Spectrometry, Fluorescence

2016
Nitric oxide-mediated resistance to photodynamic therapy in a human breast tumor xenograft model: Improved outcome with NOS2 inhibitors.
    Nitric oxide : biology and chemistry, 2017, Jan-30, Volume: 62

    Topics: Amidines; Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzoates; Benzylamines; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Female; Heterografts; Humans; Imidazoles; Light; Mice, SCID; Neoplasm Invasiveness; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sulfides; Up-Regulation

2017
5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells.
    International journal of molecular medicine, 2017, Volume: 39, Issue:2

    Topics: Aminolevulinic Acid; Apoptosis; Biological Transport; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Glioma; Humans; Intracellular Space; Mitochondria; Protoporphyrins; Radiation, Ionizing; Reactive Oxygen Species; Stress, Physiological

2017
Photodynamic Therapy Effectively Treats Actinic Keratoses Without Pre-Illumination Incubation Time.
    Journal of drugs in dermatology : JDD, 2017, Mar-01, Volume: 16, Issue:3

    Topics: Aminolevulinic Acid; Face; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp; Sunlight; Time Factors; Treatment Outcome

2017
Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology.
    Journal of biomedical optics, 2017, 04-01, Volume: 22, Issue:4

    Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Diagnostic Imaging; Disease-Free Survival; Glioma; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Optics and Photonics; Phantoms, Imaging; Protoporphyrins; Sepharose; Signal-To-Noise Ratio

2017
Activity of phosphatase-sensitive 5-aminolevulinic acid prodrugs in cancer cell lines.
    Journal of photochemistry and photobiology. B, Biology, 2017, Volume: 171

    Topics: A549 Cells; Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Humans; Light; MCF-7 Cells; Microscopy, Confocal; Neoplasms; Phosphoric Monoester Hydrolases; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins

2017
Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite.
    Nature communications, 2017, 05-11, Volume: 8

    Topics: Aminolevulinic Acid; Anti-Bacterial Agents; Biosynthetic Pathways; Drug Resistance, Bacterial; Escherichia coli; Genome, Bacterial; Heme; Iron Deficiencies; Metalloids; Microbial Sensitivity Tests; Models, Biological; Mutation; Protoporphyrins; Superoxides; Tellurium

2017
Characterization of first hemin-requiring Pseudomonas aeruginosa small-colony variants from the blood of an octogenarian male-patient with double pneumonitis.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2017, Volume: 23, Issue:12

    Topics: Aged, 80 and over; Amino Acid Sequence; Aminolevulinic Acid; Base Sequence; Culture Media; Hemin; Humans; Male; Pneumonia, Bacterial; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas Infections; RNA, Ribosomal, 16S; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2017
ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Glioma; Humans; Hypothermia, Induced; Magnetic Resonance Imaging; Male; Neurons; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Rats, Wistar; Temperature

2017
Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors.
    Scientific reports, 2017, 08-25, Volume: 7, Issue:1

    Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Electronic Data Processing; Glioma; Humans; Neurosurgery; Optical Imaging; Phantoms, Imaging; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted

2017
Protein 4.1R is Involved in the Transport of 5-Aminolevulinic Acid by Interaction with GATs in MEF Cells.
    Photochemistry and photobiology, 2018, Volume: 94, Issue:1

    Topics: Aminolevulinic Acid; Analysis of Variance; Animals; Cell Line; Fibroblasts; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Mice; Mice, Knockout; Microfilament Proteins; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Tiagabine

2018
Synthesis and evaluation of new 5-aminolevulinic acid derivatives as prodrugs of protoporphyrin for photodynamic therapy.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2017, Nov-08, Volume: 16, Issue:11

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred Strains; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Structure-Activity Relationship; Tumor Cells, Cultured

2017
Intraoperative 5-aminolevulinic acid-induced photodynamic diagnosis of metastatic brain tumors with histopathological analysis.
    World journal of surgical oncology, 2017, Sep-29, Volume: 15, Issue:1

    Topics: Adult; Aged; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Fluorescence; Humans; Intraoperative Care; Magnetic Resonance Imaging; Male; Margins of Excision; Middle Aged; Neoplasm Invasiveness; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Retrospective Studies; Surgery, Computer-Assisted

2017
Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ.
    Photodiagnosis and photodynamic therapy, 2017, Volume: 20

    Topics: Aminolevulinic Acid; Animals; Biomarkers; Dose-Response Relationship, Drug; Female; Keratinocytes; Lighting; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; STAT3 Transcription Factor; Sunlight

2017
Photodynamic therapy using a cytotoxic photosensitizer porphyrus envelope that targets the cell membrane.
    Photodiagnosis and photodynamic therapy, 2017, Volume: 20

    Topics: Aminolevulinic Acid; Cell Death; Cell Line, Tumor; Drug Delivery Systems; Humans; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sendai virus; Viral Envelope Proteins

2017
Quantifying the radiant exposure and effective dose in patients treated for actinic keratoses with topical photodynamic therapy using daylight and LED white light.
    Physics in medicine and biology, 2018, 01-26, Volume: 63, Issue:3

    Topics: Administration, Topical; Aminolevulinic Acid; Humans; Keratosis, Actinic; Light; Lighting; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation Dosage; Radiometry

2018
Image Gallery: Pitfalls when measuring protoporphyrin IX during photodynamic therapy.
    The British journal of dermatology, 2017, Volume: 177, Issue:5

    Topics: Aminolevulinic Acid; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2017
Novel potential photodynamic therapy strategy using 5-Aminolevulinic acid for ovarian clear-cell carcinoma.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 21

    Topics: Adenocarcinoma, Clear Cell; Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Combined Modality Therapy; Female; Humans; Ovarian Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Real-Time Polymerase Chain Reaction; RNA, Messenger

2018
Poly(methyl vinyl ether-alt-maleic acid) and ethyl monoester as building polymers for drug-loadable electrospun nanofibers.
    Scientific reports, 2017, 12-08, Volume: 7, Issue:1

    Topics: Aminolevulinic Acid; Cell Line; Drug Carriers; Drug Liberation; Electricity; Esters; Humans; Maleic Anhydrides; Nanofibers; Photochemotherapy; Polyvinyls; Protoporphyrins

2017
Resistance of oral cancer cells to 5-ALA-mediated photodynamic therapy.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:4

    Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Humans; Mouth Neoplasms; Photochemotherapy; Protoporphyrins; Signal Transduction; TOR Serine-Threonine Kinases

2018
Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 21

    Topics: Adenocarcinoma; Aminolevulinic Acid; Breast Neoplasms; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Liver Neoplasms; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen

2018
Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma.
    World neurosurgery, 2018, Volume: 113

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Biotransformation; Brain Neoplasms; Cell Line, Tumor; Female; Fiber Optic Technology; Fluorescent Dyes; Genes, Reporter; Glioma; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Fluorescence; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Transplantation; Neuroendoscopes; Neuroendoscopy; Photobleaching; Photosensitizing Agents; Protoporphyrins; Single-Cell Analysis; Surgery, Computer-Assisted

2018
Verification of radiodynamic therapy by medical linear accelerator using a mouse melanoma tumor model.
    Scientific reports, 2018, 02-09, Volume: 8, Issue:1

    Topics: Aminolevulinic Acid; Animals; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Particle Accelerators; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Tumor Cells, Cultured; X-Rays

2018
Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo.
    Lasers in surgery and medicine, 2018, Volume: 50, Issue:5

    Topics: Aminolevulinic Acid; Cell Culture Techniques; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Photopheresis; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; T-Lymphocytes

2018
Spectrophotometric photodynamic diagnosis of prostate cancer cells excreted in voided urine using 5-aminolevulinic acid.
    Lasers in medical science, 2018, Volume: 33, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Area Under Curve; Biomarkers, Tumor; Biopsy; Cell Line, Tumor; Humans; Male; Middle Aged; Multivariate Analysis; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Protoporphyrins; Spectrophotometry

2018
Photodynamic diagnosis with methyl-5-aminolevulinate in squamous intraepithelial lesions of the vulva: Experimental research.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Cell Line; Computer Systems; Female; Heterografts; Humans; Mice; Protoporphyrins; Spectrometry, Fluorescence; Squamous Intraepithelial Lesions of the Cervix; Tissue Distribution; Vulvar Neoplasms

2018
Potential involvement of the 18 kDa translocator protein and reactive oxygen species in apoptosis of THP-1 macrophages induced by sonodynamic therapy.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; Cytochromes c; Humans; Macrophages; Membrane Potential, Mitochondrial; Mitochondria; Protoporphyrins; Reactive Oxygen Species; Receptors, GABA; THP-1 Cells; Ultrasonic Therapy

2018
A Simply Modified Lymphocyte for Systematic Cancer Therapy.
    Advanced materials (Deerfield Beach, Fla.), 2018, Volume: 30, Issue:31

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Lasers; Levulinic Acids; Lymph Nodes; Lymphocytes; Microscopy, Fluorescence; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; ras Proteins; Reactive Oxygen Species; Tissue Distribution

2018
Measurements of the optical coefficients of the protoporphyrin IX endogenously producing yeast-based model in the visible and NIR.
    Journal of biomedical optics, 2018, Volume: 23, Issue:7

    Topics: Aminolevulinic Acid; Models, Biological; Monte Carlo Method; Phantoms, Imaging; Protoporphyrins; Spectroscopy, Near-Infrared; Yeasts

2018
Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?
    Neurosurgery, 2019, 06-01, Volume: 84, Issue:6

    Topics: Adult; Aminolevulinic Acid; Biomarkers; Biopsy; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Prognosis; Protoporphyrins

2019
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.
    Scientific reports, 2018, 08-22, Volume: 8, Issue:1

    Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Equipment Design; Female; Fluorescence; Fluorescent Dyes; Glioma; Mice, Mutant Strains; Microscopy, Fluorescence; Neoplasms, Experimental; Neuronavigation; Neurosurgical Procedures; Photobleaching; Protoporphyrins

2018
A study of concentration changes of Protoporphyrin IX and Coproporphyrin III in mixed samples mimicking conditions inside cancer cells for Photodynamic Therapy.
    PloS one, 2018, Volume: 13, Issue:8

    Topics: Aminolevulinic Acid; Animals; Coproporphyrins; Equipment Design; Fiber Optic Technology; In Vitro Techniques; Neoplasms; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

2018
Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery.
    Analytical chemistry, 2018, 10-16, Volume: 90, Issue:20

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Laser Therapy; Mass Spectrometry; Microscopy, Fluorescence; Molecular Conformation; Optical Imaging; Prodrugs; Protoporphyrins

2018
Nonlinear relation between concentration and fluorescence emission of protoporphyrin IX in calibrated phantoms.
    Journal of biomedical optics, 2018, Volume: 23, Issue:9

    Topics: Aminolevulinic Acid; Calibration; Nonlinear Dynamics; Phantoms, Imaging; Protoporphyrins; Spectrometry, Fluorescence

2018
Design and validation of an open-source modular Microplate Photoirradiation System for high-throughput photobiology experiments.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Aminolevulinic Acid; Computer Graphics; Humans; Light; Photobiology; Photobleaching; Photochemotherapy; Photosensitivity Disorders; Protoporphyrins; Radiation; Wireless Technology

2018
Metabolic abnormalities in adult T-cell leukemia/lymphoma and induction of specific leukemic cell death using photodynamic therapy.
    Scientific reports, 2018, 10-08, Volume: 8, Issue:1

    Topics: Adult; Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Humans; Leukemia-Lymphoma, Adult T-Cell; Metabolomics; Photochemotherapy; Protoporphyrins

2018
Sequentially self-assembled polysaccharide-based nanocomplexes for combined chemotherapy and photodynamic therapy of breast cancer.
    Carbohydrate polymers, 2019, Jan-01, Volume: 203

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Chitosan; Doxorubicin; Drug Carriers; Drug Liberation; Fluorescence; Humans; Hyaluronic Acid; Light; MCF-7 Cells; Mice; Nanoparticles; Particle Size; Photosensitizing Agents; Protoporphyrins

2019
Accumulation of protoporphyrin IX in medulloblastoma cell lines and sensitivity to subsequent photodynamic treatment.
    Journal of photochemistry and photobiology. B, Biology, 2018, Volume: 189

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Ferrochelatase; Humans; Medulloblastoma; Photochemotherapy; Protoporphyrins

2018
Improving in vitro photodynamic therapy through the development of a novel iron chelating aminolaevulinic acid prodrug.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 25

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Humans; Iron Chelating Agents; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Pyridones; Skin Neoplasms

2019
Comparative Study of the Effects of Ferrochelatase-siRNA Transfection Mediated by Ultrasound Microbubbles and Polyethyleneimine in Combination with Low-dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models.
    Photochemistry and photobiology, 2019, Volume: 95, Issue:4

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Endometrial Neoplasms; Female; Ferrochelatase; Humans; Mice; Mice, Nude; Microbubbles; Neoplasms, Experimental; Photosensitizing Agents; Polyethyleneimine; Protoporphyrins; RNA, Small Interfering; Ultrasonics; Xenograft Model Antitumor Assays

2019
Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cel
    Photodiagnosis and photodynamic therapy, 2019, Volume: 25

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blotting, Western; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Ferrochelatase; Heme Oxygenase-1; Humans; Lung Neoplasms; Neoplasm Metastasis; Peptide Transporter 1; Photochemotherapy; Protoporphyrins; Real-Time Polymerase Chain Reaction; Spectrometry, Fluorescence; Uroporphyrinogens

2019
Enhancing magnetic resonance/photoluminescence imaging-guided photodynamic therapy by multiple pathways.
    Biomaterials, 2019, Volume: 199

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Female; Fluorescence; Luminescence; Magnetic Resonance Imaging; Mice, Inbred BALB C; Nanoparticles; Photochemotherapy; Protoporphyrins; Subcellular Fractions; Theranostic Nanomedicine; Tissue Distribution

2019
Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid-mediated Protoporphyrin IX by Iron Chelator Deferoxamine.
    Photochemistry and photobiology, 2019, Volume: 95, Issue:4

    Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Deferoxamine; Epithelial Cells; Female; Ferrochelatase; Gene Silencing; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Siderophores

2019
Mitotic Catastrophe Induced in HeLa Tumor Cells by Photodynamic Therapy with Methyl-aminolevulinate.
    International journal of molecular sciences, 2019, Mar-11, Volume: 20, Issue:5

    Topics: Aminolevulinic Acid; Biomarkers; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; HeLa Cells; Humans; Microtubules; Mitosis; Photochemotherapy; Photosensitizing Agents; Protein Transport; Protoporphyrins; Spindle Apparatus

2019
Daylight PDT acts by continuous activation of PpIX.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 27

    Topics: Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sunlight; Time Factors

2019
Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas.
    Neurosurgery, 2019, 10-01, Volume: 85, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Kinetics; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Young Adult

2019
ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD.
    PloS one, 2019, Volume: 14, Issue:5

    Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Diketopiperazines; Female; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Neoplasm Proteins; Neoplasm Transplantation; Neoplastic Stem Cells; Photosensitizing Agents; Protoporphyrins; Single-Cell Analysis; Up-Regulation

2019
Optimizing 5-ALA Induced Fluorescence Visualization: Comment Regarding Recent Article on Fluorescence-Based Real-Time Kinetics Protoporphyrin-IX Measurements Article in Neurosurgery.
    World neurosurgery, 2019, Volume: 128

    Topics: Aminolevulinic Acid; Fluorescence; Glioma; Humans; Kinetics; Neurosurgery; Photosensitizing Agents; Protoporphyrins

2019
Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro.
    Journal of biophotonics, 2019, Volume: 12, Issue:10

    Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Drug Synergism; Glioblastoma; Humans; Methadone; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2019
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
    Cellular and molecular gastroenterology and hepatology, 2019, Volume: 8, Issue:4

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Oxygen; Photosensitivity Disorders; Photosensitizing Agents; Porphyrias; Porphyrins; Protein Aggregates; Protein Conformation; Protoporphyrins

2019
Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis.
    Scientific reports, 2019, 06-17, Volume: 9, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Dynamin II; Exocytosis; Heme; Humans; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Trimethyl Ammonium Compounds; Ultraviolet Rays

2019
Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 27

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Humans; Membrane Transport Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; RNA, Small Interfering

2019
Is the Intensity of 5-Aminolevulinic Acid-Derived Fluorescence Related to the Light Source?
    World neurosurgery, 2019, Volume: 131

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Light; Neurosurgical Procedures; Protoporphyrins

2019
Quantification of PpIX-fluorescence of cerebral metastases: a pilot study.
    Clinical & experimental metastasis, 2019, Volume: 36, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescent Dyes; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; Optical Imaging; Pilot Projects; Prognosis; Prospective Studies; Protoporphyrins

2019
Fluorescence-based discrimination of breast cancer cells by direct exposure to 5-aminolevulinic acid.
    Cancer medicine, 2019, Volume: 8, Issue:12

    Topics: Aminolevulinic Acid; Animals; Biopsy, Fine-Needle; Breast Neoplasms; Cell Line, Tumor; Diketopiperazines; Female; Heterocyclic Compounds, 4 or More Rings; Humans; MCF-7 Cells; Mice; Microscopy, Confocal; Protoporphyrins; Xenograft Model Antitumor Assays

2019
Biosensor device for the photo-specific detection of immuno-captured bladder cancer cells using hexaminolevulinate: An ex-vivo study.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 28

    Topics: Aminolevulinic Acid; Biosensing Techniques; Cell Line, Tumor; Cystoscopy; Humans; In Vitro Techniques; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms; Urine

2019
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.
    Acta neurochirurgica, 2019, Volume: 161, Issue:10

    Topics: Adolescent; Aminolevulinic Acid; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Fluorescence; Glioma; Humans; Infant; Male; Protoporphyrins; Spectrum Analysis

2019
Impact of thiosemicarbazones on the accumulation of PpIX and the expression of the associated genes.
    Journal of photochemistry and photobiology. B, Biology, 2019, Volume: 199

    Topics: A549 Cells; Aminolevulinic Acid; Antineoplastic Agents; Cell Survival; Drug Design; Ferrochelatase; Gene Expression Regulation; HCT116 Cells; Heme Oxygenase (Decyclizing); Humans; Iron; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Thiosemicarbazones

2019
Antimalarial Drugs Enhance the Cytotoxicity of 5-Aminolevulinic Acid-Based Photodynamic Therapy against the Mammary Tumor Cells of Mice In Vitro.
    Molecules (Basel, Switzerland), 2019, Oct-29, Volume: 24, Issue:21

    Topics: Acetylcysteine; Aminolevulinic Acid; Animals; Antimalarials; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Shape; Female; Fluorescence; Mammary Neoplasms, Animal; Mice; Photochemotherapy; Protoporphyrins; Reactive Oxygen Species

2019
Use of dermograph for improvement of PpIX precursor's delivery in photodynamic therapy: Experimental and clinical pilot studies.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 29

    Topics: Aminolevulinic Acid; Animals; Neoplasm Recurrence, Local; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Rats; Skin Neoplasms

2020
Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization.
    Journal of photochemistry and photobiology. B, Biology, 2019, Volume: 201

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Fluorescent Dyes; Genistein; Glioblastoma; Heme Oxygenase-1; Humans; Metalloporphyrins; Microscopy, Confocal; Neoplasm Proteins; Protoporphyrins

2019
Smartphone fluorescence imager for quantitative dosimetry of protoporphyrin-IX-based photodynamic therapy in skin.
    Journal of biomedical optics, 2019, Volume: 25, Issue:6

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Equipment Design; Humans; Imaging, Three-Dimensional; Keratosis, Actinic; Mice; Mice, Nude; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiometry; Smartphone

2019
The effect of glucose and human serum on 5-aminolevulinic acid mediated photodynamic inactivation of Candida albicans.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 29

    Topics: Aminolevulinic Acid; Biofilms; Candida albicans; Cell Survival; Cells, Cultured; Glucose; Humans; Lasers, Semiconductor; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Serum

2020
Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.
    Scientific reports, 2020, 01-29, Volume: 10, Issue:1

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cluster Analysis; Computer Simulation; Glioma; Humans; Machine Learning; Margins of Excision; Pilot Projects; Predictive Value of Tests; Prognosis; Protoporphyrins; Spectrometry, Fluorescence

2020
Skin surface Protoporphyrin IX fluorescence is associated with epidermal but not dermal fluorescence intensities.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 30

    Topics: Aminolevulinic Acid; Epidermis; Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2020
Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study.
    Acta neurochirurgica, 2020, Volume: 162, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Cell Count; Female; Fluorescence; Glioma; Humans; Male; Margins of Excision; Microscopy, Fluorescence; Middle Aged; Neurosurgical Procedures; Photosensitizing Agents; Predictive Value of Tests; Prospective Studies; Protoporphyrins; Surgery, Computer-Assisted

2020
5-ALA-assistant automated detection of lymph node metastasis in gastric cancer patients.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2020, Volume: 23, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Fluorescent Dyes; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Photosensitizing Agents; Prognosis; Protoporphyrins; Retrospective Studies; Stomach Neoplasms

2020
Fluorescence detection of deep intramucosal cancer excited by green light for photodynamic diagnosis using protoporphyrin IX induced by 5-aminolevulinic acid: an ex vivo study.
    Journal of biomedical optics, 2020, Volume: 25, Issue:6

    Topics: Aminolevulinic Acid; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Stomach Neoplasms; Swine

2020
DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma.
    International journal of molecular sciences, 2020, Mar-26, Volume: 21, Issue:7

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; DNA Breaks, Double-Stranded; Melanoma; Mice; Protoporphyrins; Radiation-Sensitizing Agents; Reactive Oxygen Species; X-Ray Therapy; X-Rays

2020
Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2021, Jan-08, Volume: 87, Issue:6

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Fluorescence; Gene Expression; Glioma; Humans; Protoporphyrins; RNA, Messenger; Ultrasonography

2021
Probing Hexaminolevulinate Mediated PpIX Fluorescence in Cancer Cell Suspensions in the Presence of Chemical Adjuvants.
    International journal of molecular sciences, 2020, Apr-22, Volume: 21, Issue:8

    Topics: Aminolevulinic Acid; Biosynthetic Pathways; Cell Line, Tumor; Fluorescence; Heme; Humans; Molecular Imaging; Photosensitizing Agents; Protoporphyrins

2020
Temperature effect on the PpIX production during the use of topical precursors.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 30

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Temperature

2020
Evaluation of the effect of 5-aminolevulinic acid hexyl ester (H-ALA) PDT on EBV LMP1 protein expression in human nasopharyngeal cells.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 30

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Herpesvirus 4, Human; Humans; Lasers, Semiconductor; Low-Level Light Therapy; Nasopharyngeal Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Viral Matrix Proteins

2020
Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas.
    Acta neurochirurgica, 2020, Volume: 162, Issue:9

    Topics: Aminolevulinic Acid; Fluorescence; Glioblastoma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted

2020
Epigallocatechin Gallate Enhances MAL-PDT Cytotoxic Effect on PDT-Resistant Skin Cancer Squamous Cells.
    International journal of molecular sciences, 2020, May-08, Volume: 21, Issue:9

    Topics: Aminolevulinic Acid; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Catechin; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Ferrochelatase; Heat-Shock Proteins; Humans; Membrane Transport Proteins; Molecular Chaperones; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Skin Neoplasms; Stress, Physiological; Superoxide Dismutase; Survivin; Symporters

2020
In-vitro investigation of cold atmospheric plasma induced photodynamic effect by Indocyanine green and Protoporphyrin IX.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 31

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Humans; Indocyanine Green; Photochemotherapy; Photosensitizing Agents; Plasma Gases; Protoporphyrins

2020
Relationship between tumor cell infiltration and 5-aminolevulinic acid fluorescence signals after resection of MR-enhancing lesions and its prognostic significance in glioblastoma.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021, Volume: 23, Issue:3

    Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Cell Movement; Cerebral Ventricles; DNA Modification Methylases; DNA Repair Enzymes; Female; Fluorescence; Glioblastoma; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Photosensitizing Agents; Prognosis; Progression-Free Survival; Protoporphyrins; Retrospective Studies; Tumor Suppressor Proteins

2021
A facile fabrication of dissolving microneedles containing 5-aminolevulinic acid.
    International journal of pharmaceutics, 2020, Aug-30, Volume: 586

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Drug Delivery Systems; Drug Stability; Drug Storage; Hyaluronic Acid; Needles; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Rats; Skin; Solubility

2020
ABCG2 influence on the efficiency of photodynamic therapy in glioblastoma cells.
    Journal of photochemistry and photobiology. B, Biology, 2020, Volume: 210

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Doxycycline; Glioblastoma; Humans; Light; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Up-Regulation

2020
Evaluation of aminolevulinic acid-mediated protoporphyrin IX fluorescence and enhancement by ABCG2 inhibitors in renal cell carcinoma cells.
    Journal of photochemistry and photobiology. B, Biology, 2020, Volume: 211

    Topics: Aminolevulinic Acid; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Carcinoma, Renal Cell; Cell Line, Tumor; Drug Screening Assays, Antitumor; Ferrochelatase; Humans; Kidney Neoplasms; Lapatinib; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction

2020
Dissolving microneedles containing aminolevulinic acid improves protoporphyrin IX distribution.
    Journal of biophotonics, 2021, Volume: 14, Issue:1

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin

2021
Rapid (FLASH-FLIM) imaging of protoporphyrin IX in a lipid mixture using a CMOS based widefield fluorescence lifetime imaging camera in real time for margin demarcation applications.
    Methods and applications in fluorescence, 2021, Jan-11, Volume: 9, Issue:1

    Topics: Aminolevulinic Acid; Lipids; Optical Imaging; Protoporphyrins

2021
Thermo-Mechanical Fractional Injury Enhances Skin Surface- and Epidermis- Protoporphyrin IX Fluorescence: Comparison of 5-Aminolevulinic Acid in Cream and Gel Vehicles.
    Lasers in surgery and medicine, 2021, Volume: 53, Issue:5

    Topics: Aminolevulinic Acid; Epidermis; Humans; Photochemotherapy; Protoporphyrins

2021
Modulation of aminolevulinic acid-based photoinactivation efficacy by iron in vitro is cell type dependent.
    Journal of photochemistry and photobiology. B, Biology, 2020, Volume: 213

    Topics: Aminolevulinic Acid; Cell Line; Culture Media; Heme; Humans; Iron; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence

2020
MAL-associated methyl nicotinate for topical PDT improvement.
    Journal of photochemistry and photobiology. B, Biology, 2020, Volume: 213

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Cell Line; Cell Survival; Humans; Male; NAD; Nicotinic Acids; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats, Wistar; Skin; Skin Diseases

2020
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
    Journal of neuro-oncology, 2021, Volume: 152, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Optical Imaging; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted

2021
Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery.
    Molecular imaging and biology, 2021, Volume: 23, Issue:4

    Topics: 4-Chloro-7-nitrobenzofurazan; Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Cell Proliferation; Deoxyglucose; Female; Fluorescence; Glioma; Glucose; Humans; Mice; Mice, Inbred C57BL; Molecular Imaging; Monitoring, Intraoperative; Protoporphyrins; Surgery, Computer-Assisted; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2021
Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid: A novel approach towards enhanced accumulation of protoporphyrin IX for photodynamic therapy.
    Bioorganic chemistry, 2021, Volume: 109

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Drug Design; Humans; Molecular Structure; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Structure-Activity Relationship

2021
Biotin-Containing Third Generation Glucoheptoamidated Polyamidoamine Dendrimer for 5-Aminolevulinic Acid Delivery System.
    International journal of molecular sciences, 2021, Feb-17, Volume: 22, Issue:4

    Topics: Amides; Aminolevulinic Acid; Biotin; Caco-2 Cells; Cell Death; Cell Survival; Dendrimers; Drug Delivery Systems; Fluorescence; Humans; Intracellular Space; Polyamines; Proton Magnetic Resonance Spectroscopy; Protoporphyrins; Reactive Oxygen Species

2021
Mass Spectrometric Analysis of the Photobleaching of Protoporphyrin IX Used in Photodynamic Diagnosis and Therapy of Cancer.
    Photochemistry and photobiology, 2021, Volume: 97, Issue:5

    Topics: Aminolevulinic Acid; Humans; Mass Spectrometry; Neoplasms; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2021
Improving hexaminolevulinate enabled cancer cell detection in liquid biopsy immunosensors.
    Scientific reports, 2021, 03-31, Volume: 11, Issue:1

    Topics: Aminolevulinic Acid; Biosensing Techniques; Cell Line, Tumor; Cells, Cultured; Humans; Immunologic Tests; Liquid Biopsy; Microfluidics; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder Neoplasms; Urothelium

2021
Efficiency of aminolevulinic acid (ALA)-photodynamic therapy based on ALA uptake transporters in a cell density-dependent malignancy model.
    Journal of photochemistry and photobiology. B, Biology, 2021, Volume: 218

    Topics: Adaptor Proteins, Signal Transducing; Aminolevulinic Acid; Antineoplastic Agents; Biological Transport; Cell Count; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Humans; Light; Membrane Transport Proteins; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Transcription Factors; YAP-Signaling Proteins

2021
Protein-aggregating ability of different protoporphyrin-IX nanostructures is dependent on their oxidation and protein-binding capacity.
    The Journal of biological chemistry, 2021, Volume: 297, Issue:1

    Topics: Aminolevulinic Acid; Animals; Binding Sites; Cattle; Cell Line; Deferoxamine; Dimerization; Humans; Hydrogen-Ion Concentration; Models, Biological; Nanostructures; Oxidation-Reduction; Protein Aggregates; Protein Binding; Protein Structure, Secondary; Protoporphyrins; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

2021
In Vivo Assessment of Mitochondrial Oxygen Consumption.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2277

    Topics: Aminolevulinic Acid; Animals; Body Temperature; Equipment Design; Luminescent Measurements; Mitochondria; Oxygen Consumption; Protoporphyrins; Rats, Wistar; Respiration, Artificial; Skin; Tracheotomy

2021
Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma.
    Journal of neurosurgery, 2022, Jan-01, Volume: 136, Issue:1

    Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Chromosome Deletion; Female; Fluorescence; Glioma; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Male; Middle Aged; Photosensitizing Agents; Positron-Emission Tomography; Protoporphyrins; Radiopharmaceuticals; Spectrometry, Fluorescence; Tyrosine

2022
Experimental investigation of a combinational iron chelating protoporphyrin IX prodrug for fluorescence detection and photodynamic therapy.
    Lasers in medical science, 2022, Volume: 37, Issue:2

    Topics: Aminolevulinic Acid; Fluorescence; Humans; Iron Chelating Agents; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins

2022
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.
    Scientific reports, 2021, 07-23, Volume: 11, Issue:1

    Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Down-Regulation; Glioblastoma; Glioma; Male; Mice; Mice, Inbred C57BL; Neoplastic Stem Cells; NF-kappa B; Photosensitizing Agents; Proto-Oncogene Proteins c-akt; Protoporphyrins; Signal Transduction; Ultrasonic Therapy

2021
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 142

    Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Humans; Hyperparathyroidism, Secondary; Organoids; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sirolimus; Time Factors

2021
REAP (Rapid Elimination of Active Plasmodium): A photodynamic strategy exploiting intrinsic kinetics of the parasite to combat severe malaria.
    Journal of photochemistry and photobiology. B, Biology, 2021, Volume: 223

    Topics: Aminolevulinic Acid; Antimalarials; Drug Resistance; Erythrocytes; Humans; Kinetics; Light; Malaria; Photochemotherapy; Photosensitizing Agents; Plasmodium falciparum; Protoporphyrins; Severity of Illness Index

2021
Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin.
    BMC cancer, 2021, Aug-30, Volume: 21, Issue:1

    Topics: Aminolevulinic Acid; Carbazoles; Fluorescence; Humans; Light; Neoplasms; Photochemotherapy; Photosensitizing Agents; Piperidines; Protoporphyrins; Tumor Cells, Cultured

2021
OPD (Online Plasmodium Diagnosis): An ALA-PpIX based functional assay to predict active malaria.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 36

    Topics: Aminolevulinic Acid; Animals; Humans; Malaria; Photochemotherapy; Photosensitizing Agents; Plasmodium; Protoporphyrins

2021
Small molecule kinase inhibitors enhance aminolevulinic acid-mediated protoporphyrin IX fluorescence and PDT response in triple negative breast cancer cell lines.
    Journal of biomedical optics, 2021, Volume: 26, Issue:9

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Triple Negative Breast Neoplasms

2021
Synthesis and photodynamic efficacy of water-soluble protoporphyrin IX homologue with mPEG550.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 36

    Topics: Aminolevulinic Acid; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectroscopy, Fourier Transform Infrared; Water

2021
Photodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line.
    Photodiagnosis and photodynamic therapy, 2022, Volume: 37

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Gliosarcoma; Humans; Lac Operon; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2022
Methods to Measure the Inhibition of ABCG2 Transporter and Ferrochelatase Activity to Enhance Aminolevulinic Acid-Protoporphyrin IX Fluorescence-Guided Tumor Detection and Resection.
    Methods in molecular biology (Clifton, N.J.), 2022, Volume: 2394

    Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors; Ferrochelatase; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2022
First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence.
    Journal of biomedical optics, 2022, Volume: 27, Issue:2

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Humans; Margins of Excision; Photosensitizing Agents; Protoporphyrins

2022
Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines.
    Biochemical pharmacology, 2022, Volume: 200

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Ferrochelatase; Fluorescence; Glioma; Humans; Lapatinib; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2022
Identification and pharmacological modification of resistance mechanisms to protoporphyrin-mediated photodynamic therapy in human cutaneous squamous cell carcinoma cell lines.
    Photodiagnosis and photodynamic therapy, 2022, Volume: 39

    Topics: Aminolevulinic Acid; ATP-Binding Cassette Transporters; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms

2022
Analysis of Renal Cell Carcinoma Cell Response to the Enhancement of 5-aminolevulinic Acid-mediated Protoporphyrin IX Fluorescence by Iron Chelator Deferoxamine
    Photochemistry and photobiology, 2023, Volume: 99, Issue:2

    Topics: Aminolevulinic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Deferoxamine; Fluorescence; Heme; Humans; Iron; Iron Chelating Agents; Kidney Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2023
Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds.
    Cancer treatment and research communications, 2022, Volume: 32

    Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Hyperspectral Imaging; Photosensitizing Agents; Protoporphyrins

2022
Protoporphyrin IX delayed fluorescence imaging: a modality for hypoxia-based surgical guidance.
    Journal of biomedical optics, 2022, Volume: 27, Issue:10

    Topics: Aminolevulinic Acid; Fluorescence; Humans; Hypoxia; Neoplasms; Oxygen; Photosensitizing Agents; Protoporphyrins

2022
Desferrioxamine Enhances 5-Aminolaevulinic Acid- Induced Protoporphyrin IX Accumulation and Therapeutic Efficacy for Hypertrophic Scar.
    Journal of pharmaceutical sciences, 2023, Volume: 112, Issue:6

    Topics: Aminolevulinic Acid; Cicatrix, Hypertrophic; Deferoxamine; Humans; Iron Chelating Agents; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2023
Increased fluorescence observation intensity during the photodynamic diagnosis of deeply located tumors by fluorescence photoswitching of protoporphyrin IX.
    Journal of biomedical optics, 2023, Volume: 28, Issue:5

    Topics: Aminolevulinic Acid; Fluorescence; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

2023
Combining Pr
    ACS applied bio materials, 2023, 06-19, Volume: 6, Issue:6

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioblastoma; Humans; Photochemotherapy; X-Rays

2023
A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin.
    Communications biology, 2023, 06-24, Volume: 6, Issue:1

    Topics: Aminolevulinic Acid; Animals; Cell Death; Heme; Mammals; Peroxiredoxins; Proteomics

2023
Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study.
    Journal of biomedical optics, 2023, Volume: 28, Issue:10

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins

2023