protoporphyrin ix has been researched along with aminolevulinic acid in 860 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (0.81) | 18.7374 |
1990's | 169 (19.65) | 18.2507 |
2000's | 311 (36.16) | 29.6817 |
2010's | 313 (36.40) | 24.3611 |
2020's | 60 (6.98) | 2.80 |
Authors | Studies |
---|---|
Callan, JF; Jack, IG; Kavanagh, ON; Loan, P; McEwan, C; McHale, AP; McKenna, K; Nesbitt, H; Nicholas, D | 1 |
Kennedy, JC; Pottier, RH | 1 |
Arkins, S; Kelley, KW; Rebeiz, CA; Rebeiz, CC; Rebeiz, N | 1 |
Bedwell, J; Bown, SG; MacRobert, AJ; Phillips, D | 1 |
Febre, EF; Javor, GT | 1 |
Cox, TM; Gardner, LC; Smith, SJ | 1 |
Kennedy, JC; Pottier, RH; Pross, DC | 1 |
Divaris, DX; Kennedy, JC; Pottier, RH | 1 |
Cutler, MG; Mair, J; Moore, MR | 1 |
Arrol, S; Cutler, MG | 1 |
Kramer, S; Siepker, LJ | 1 |
Chambon, H; Labbe, P | 1 |
González Ramírez, JD; Molina-Ballesteros, G; Navarrete-Cadena, C; Zúñiga-Charles, MA | 1 |
Fukui, S; Isobe, N; Kamihara, T; Nakamura, I; Nakamura, N | 1 |
Novogrodsky, A; Rubin, AL; Stenzel, KH | 1 |
Lee, CJ; Lofgren, LA; Nouri, M; Ronn, AM; Steinberg, BM; Yoo, D | 1 |
Cairnduff, F; Roberts, DJ | 1 |
Brown, NJ; Leveckis, J; Reed, MW | 1 |
Abels, C; Bäumler, W; Fritsch, C; Goerz, G; Goetz, AE; Karrer, S; Landthaler, M; Steinbach, P; Szeimies, RM | 1 |
Hayashi, N | 1 |
Harada, K; Kim, Y; Ohmori, S; Tomokuni, K | 1 |
Ehrenberg, B; Kostenich, G; Malik, Z; Orenstein, A; Roitman, L | 1 |
Bown, SG; Conio, M; MacRobert, AJ; Messmann, H; Millson, CE; Mĺkvy, P; Pauer, M; Regula, J | 2 |
Bazin, M; Dubertret, L; Gaullier, JM; Gèze, M; Mazière, JC; Morlière, P; Sa e Melo, T; Santus, R | 1 |
Bown, SG; Buonaccorsi, G; Davies, CL; MacRobert, AJ; Messmann, H; Mlkvy, P | 1 |
Bown, SG; Grant, WE; Hopper, C; MacRobert, AJ; Speight, PM | 2 |
Greer, PA; Reid, RL; van Vugt, DA; Yang, JZ | 1 |
Berg, K; Luksiene, Z; Ma, L; Moan, J | 1 |
Hryhorenko, E; Morgan, J; Oseroff, AR; Paszkiewicz, G; Rittenhouse-Diakun, K; Van Leengoed, H; Whitaker, JE | 1 |
Forrer, M; Graber, P; Jichlinski, P; Leisinger, HJ; Mizeret, J; Schmidlin, F; Van den Bergh, H; Wagnière, G | 1 |
Matthews, EK; Ratcliffe, SL | 1 |
Bachor, R; Flotte, T; Hasan, T; Iinuma, S | 1 |
Andersson-Engels, S; Carlsson, K; Rokahr, I; Trepte, O | 1 |
Baumgartner, R; Ehsan, A; Hofstädter, F; Hofstetter, A; Knüchel, R; Kriegmair, M; Lumper, W; Steinbach, P | 1 |
Star, WM; van der Veen, N; van Leengoed, HL | 1 |
Baumgartner, R; Hofstädter, F; Knüchel, R; Kriegmair, M; Steinbach, P | 1 |
Berns, MW; Krasieva, T; Schell, M; Tadir, Y; Tromberg, BJ; Wyss, MT; Wyss, P | 1 |
Baumgartner, R; Ehsan, A; Hofstädter, F; Hofstetter, A; Knuechel, R; Kriegmair, M; Lumper, W; Steinbach, P | 1 |
Brown, NJ; Burn, JL; Leveckis, J; Reed, MW | 1 |
Farshi, SS; Hasan, T; Iinuma, S; Ortel, B | 1 |
Karu, T; Letokhov, V | 1 |
Bedwell, J; Bown, SG; MacRobert, AJ; Ravi, B; Regula, J | 1 |
Landthaler, M; Sassy, T; Szeimies, RM | 1 |
König, K; Rück, A; Schneckenburger, H; Steiner, R | 1 |
Ehret, W; Jacob, K; Luppa, P | 1 |
Anderson, RR; Deutsch, TF; Fewkes, JL; Flotte, TJ; Grevelink, JM; Martin, A; Starr, JC; Tope, WD | 1 |
Canti, G; Cubeddu, R; Taroni, P; Valentini, G | 1 |
de Brito, LX; Foultier, MT; Gouyette, A; Morlet, L; Patrice, T; Vonarx-Coinsman, V | 1 |
Baumgartner, R; Hofstädter, F; Knüchel, R; Kriegmair, M; Steinbach, P; Weingandt, H | 1 |
Banieghbal, E; Krammer, B; Uberriegler, KP | 1 |
Kennedy, JC; Reid, RL; Van Dijk-Smith, JP; Van Vugt, DA; Yang, JZ | 1 |
Campbell, DL; Campling, BG; Fisher, ME; Johnson, JG; Kennedy, JC; Pottier, RH; Rossi, FM | 1 |
Baumgartner, R; Ehsan, A; Hofstetter, A; Knüchel, R; Kriegmair, M; Lumper, W; Rick, K; Steinbach, P; Stepp, H; Stepp, HG | 1 |
Brown, SB; Gannon, MJ; Holroyd, JA; Johnson, N; Lilford, RJ; Roberts, DJ; Vernon, DI | 1 |
Berg, RJ; de Bruijn, HS; Star, WM; van der Veen, N | 1 |
Ehrenberg, B; Kopolovic, Y; Kostenich, G; Malik, Z; Orenstein, A; Roitman, L; Shechtman, Y | 1 |
Bown, SG; Chang, SC; MacRobert, AJ | 1 |
Fromm, D; Kessel, D; Webber, J | 4 |
Reinbothe, C; Reinbothe, S | 1 |
Berg, K; Nesland, JM; Noodt, BB; Peng, Q; Stokke, T | 1 |
Bown, SG; Kleemann, D; MacRobert, AJ; Mentzel, T; Speight, PM | 1 |
Bolsen, K; Dickson, E; Dietel, W; Fritsch, C; Pottier, R; Wendenburg, R | 1 |
Berns, MW; Haller, U; Kurlawalla, CS; Sun, CH; Tadir, Y; Wyss, P; Wyss-Desserich, MT | 1 |
Collins, P; Robinson, DJ; Sheehan-Dare, RA; Stables, GI; Stringer, MR | 2 |
Barr, H; Dix, A; Krasner, N; Roberts, DJ; Shepherd, NA; Tan, WC | 1 |
Anholt, H; Bech, O; Berg, K; Moan, J | 1 |
Berg, K; Chekulayev, V; Moan, J; Shevchuk, I | 1 |
Campbell, DL; Dickson, EF; Kennedy, JC; Pottier, RH; Rossi, FM | 1 |
Berns, MW; Svaasand, LO; Tadir, Y; Tromberg, BJ; Wyss, MT; Wyss, P | 1 |
Campbell, DL; Forkert, PG; Gudgin-Dickson, EF; Kennedy, JC; Pottier, RH | 1 |
Bachor, R; Hautmann, R; Reich, E; Rück, A | 1 |
Andersson-Engels, S; Liu, DL; Stenram, U; Svanberg, K; Svanberg, S; Wang, I | 1 |
DiSaia, PJ; Fehr, MK; Krasieva, T; Lin, F; Tadir, Y; Tromberg, BJ; Wyss, P | 1 |
Anderson, RR; Kollias, N; Rhodes, LE; Tsoukas, MM | 1 |
Gederaas, OA; Romslo, I; Thorstensen, K | 1 |
Bagdonas, S; Bech, O; Berg, K; Moan, J; Streckyte, G | 1 |
Alwin, G; Baumgartner, R; Feyh, J; Gutmann, R; Leunig, A; Rick, K; Stepp, H | 1 |
Krammer, B; Uberriegler, K | 1 |
Baumgartner, R; Gamarra, F; Huber, RM; Leberig, A; Rick, K; Roth, C; Schulz, H; Stepp, H | 1 |
Bech, O; Berg, K; Moan, J | 1 |
Berg, K; Kongshaug, M; Moan, J; Nesland, JM; Peng, Q | 1 |
Andersson-Engels, S; Berg, R; Heyerdahl, H; Liu, DL; Moan, J; Peng, Q; Svanberg, K; Svanberg, S; Wang, I | 1 |
Forrer, M; Graber, P; Guillou, L; Jichlinski, P; Leisinger, HJ; Mizeret, J; Oswald, M; Schmidlin, F; Van den Bergh, H; Wagnières, G | 1 |
Anholt, H; Berg, K; Gaullier, JM; Ma, LW; Moan, J; Peng, Q; Selbo, PK | 1 |
Bown, SG; Buonaccorsi, G; Chang, SC; MacRobert, AJ | 1 |
Berg, R; Johansson, J; Svanberg, K; Svanberg, S | 1 |
Braichotte, D; Forrer, M; Glanzmann, T; Graber, P; Guillou, L; Jichlinski, P; Leisinger, HJ; Mizeret, J; Schmidlin, F; van den Bergh, H; Wagnières, G; Zimmer, G | 1 |
Forrer, M; Graber, P; Guillou, L; Jichlinski, P; Leisinger, HJ; Mizeret, J; Schmidlin, F; Van den Bergh, H; Wagniéres, G | 1 |
Riley, PA; Washbrook, R | 1 |
Berg, K; Giercksky, KE; Kongshaug, M; Moan, J; Nesland, JM; Peng, Q; Warloe, T | 1 |
Bown, SG; Chang, SC; MacRobert, AJ; Porter, JB | 1 |
Baumgartner, R; Heil, P; Sroka, R; Stocker, S | 1 |
Alhava, E; Grönlund-Pakkanen, S; Kuusisto, A; Mäkinen, K; Talja, M | 1 |
Bazin, M; Dubertret, L; Gaullier, JM; Giraud, M; Santus, R; Valla, A | 1 |
De Bruijn, HS; Star, WM; Van der Veen, N | 1 |
Bown, SG; Buonaccorsi, GA; Chang, SC; MacRobert, AJ | 1 |
Bechara, EJ; Costa, CA; Pinto, AM; Trivelato, GC | 1 |
Berns, MW; Chapman, CF; DiSaia, PJ; Haller, U; Hiserodt, JC; Krasieva, TB; Major, AL; Rose, GS; Tadir, Y; Tromberg, BJ | 1 |
Alhava, E; Grönlund-Pakkanen, S; Kuusisto, A; Mäkinen, K; Nuutinen, P; Tiirikainen, M | 1 |
Carre, J; Eleouet, S; Gouyette, A; Ioss, P; Lajat, Y; Leray, AM; Merle, C; Patrice, T; Vonarx, V | 1 |
Krasner, N; Lombard, M; O'Toole, P; Tan, WC | 1 |
Baumgartner, R; Fuchs, C; Riesenberg, R; Siegert, J | 1 |
Brown, NJ; Burn, JL; Reed, MW; Wyld, L | 1 |
Abels, C; Doss, M; Geisler, M; Gross, U; Holstege, A; Knüchel, R; Messmann, H; Schölmerich, J; Steinbach, P; Szeimies, RM | 1 |
Fromm, D; Herman, MA; Kessel, D; Luo, Y; Patacsil, V; Webber, J | 1 |
Matovic, V; Plamenac, Z; Soldatovic, D; Vujanovic, D | 1 |
Baumgartner, R; Huber, RM; Jacob, K; Kriegmair, M; Rick, K; Sroka, R; Stepp, H | 1 |
Hamblin, MR; Hasan, T; Momma, T | 1 |
Anderson, RR; Crum, C; Kollias, N; Romero, R; Ross, EV | 1 |
Bech, O; Berg, K; Gaullier, JM; Ma, LW; Moan, J; Steen, HB; Stokke, T | 1 |
Futsaether, CM; Johnsson, A; Ramstad, S | 1 |
Carré, J; Eléouet, S; Heyman, D; Lajat, Y; Patrice, T; Vonarx, V | 1 |
Pottier, RH; Reid, RL; Roy, BN; Van Vugt, DA; Weagle, GE | 1 |
Bech, O; MacRobert, AJ; Moan, J; Phillips, D | 1 |
Brown, SB; de Bruijn, HS; Robinson, DJ; Star, WM; Stringer, MR; van der Veen, N | 2 |
Akkermans, W; Beijersbergen van Henegouwen, GM; Kloek, J | 1 |
Carroll, RL; Golub, AL; Lundahl, S; Marcus, SL; Shulman, DG; Sobel, RS | 1 |
Anderson, RR; Gillies, R; Kollias, N; Martin, A; Ross, EV; Tope, WD | 1 |
Lochs, H; Ortner, M | 1 |
Bäumler, W; Endlicher, E; Hauser, T; Knüchel, R; Kullmann, F; Messmann, H; Schölmerich, J; Szeimies, RM | 1 |
Kennedy, JC; Marcus, SL; Pottier, RH | 1 |
Harvey, NS; Hryhorenko, EA; Morgan, J; Oseroff, AR; Rittenhouse-Diakun, K; Stewart, CC | 1 |
Brown, KM; Lown, JW; McCallum, TJ; Miller, GG; Moore, RB; Tulip, J; Xiao, Z | 1 |
Brown, NJ; Reed, MW; Wyld, L | 1 |
Fromm, D; Herman, MA; Kessel, D; Webber, J | 1 |
Brown, NJ; Lawry, J; Reed, MW; Smith, O; Wyld, L | 1 |
Brissette, J; Chen, N; Dotto, GP; Hasan, T; Maytin, E; Ortel, B | 1 |
Adesokun, A; Chakrabarti, P; Egger, N; Gangula, R; Motamedi, M; Neal, DE; Orihuela, E | 1 |
de Rooij, FW; Edixhoven, A; Hinnen, P; Siersema, PD; Tilanus, HW; van Hillegersberg, R; van Velthuysen, ML; Wilson, JH | 1 |
de Bruin, RW; de Rooij, FW; Edixhoven-Bosdijk, A; Houtsmuller, AB; Siersema, PD; Tilanus, HW; van den Boogert, J; van Hillegersberg, R; Wilson, JH | 1 |
Iani, V; Ma, L; Moan, J; Peng, Q | 1 |
Bishop, CC; Bown, SG; Buonaccorsi, G; Jenkins, MP; MacRobert, A; McEwan, JR | 1 |
Ehrhardt, A; Leonhard, M; Möller, G; Reulen, HJ; Stepp, H; Stummer, W | 1 |
Hryhorenko, EA; Morgan, J; Oseroff, AR; Rittenhouse-Diakun, K | 1 |
Iani, V; Moan, J; Sørensen, R | 1 |
Krammer, B; Schnitzhofer, G; Verwanger, T | 1 |
Heimann, A; Kempski, O; Novotny, A; Plesnila, N; Reulen, HJ; Sauer, O; Stocker, S; Stummer, W; Wietzorrek, J | 1 |
Barth, T; Haase, T; Kübler, A; Mühling, J; Rheinwald, M | 1 |
Bäumler, W; Holstege, A; Knüchel, R; Messmann, H; Schölmerich, J | 1 |
Bartosová, J; Cajthamlová, H; Fuchs, O; Grebenová, D; Hrkal, Z; Klamová, H; Marinov, J | 1 |
de Bruin, RW; Siersema, PD; Tilanus, HW; van Dekken, H; van den Boogert, J; van Hillegersberg, R; van Staveren, HJ | 1 |
Cardoso, E; Clemente, LP; Clemente, MP; Montán, S; Pratas, RM; Svanberg, K; Svanberg, S; Wang, I | 1 |
Gudmundson, F; Larko, O; Mölne, L; Rosén, A; Stenquist, B; Ternesten, A; Wennberg, AM | 1 |
Geiger, PG; Girotti, AW; Korytowski, W; Lin, F | 1 |
Fraikin, GY; Ivanova, EV; Kolesnikova, OA; Strakhovskaya, MG | 1 |
Foster, TH; Georgakoudi, I; Keng, PC | 1 |
Kvam, E; Pourzand, C; Reelfs, O; Tyrrell, RM | 1 |
Iani, V; Juzenas, P; Moan, J; Sørensen, R | 1 |
Popken, G; Schultze-Seemann, W; Wetterauer, U | 1 |
Abels, C; Botzlar, A; Goetz, AE; Langer, S; Pahernik, S; Rick, K; Szeimies, RM | 1 |
Johnson, JG; Kennedy, JC; Li, G; Pottier, RH; Raptis, L; Szewczuk, MR; Weagle, GE | 1 |
Gibson, SL; Havens, JJ; Hilf, R; Nguyen, ML | 1 |
Forrer, M; Guillou, L; Jichlinski, P; Kucera, P; Lange, N; Marti, A; van den Bergh, H; Wagnières, G; Zellweger, M | 1 |
af Klinteberg, C; Andersson-Engels, S; Enejder, AM; Svanberg, K; Svanberg, S; Wang, I | 1 |
Berg, K; Dubbelman, TM; Gederaas, OA; Lagerberg, JW; Rasch, MH | 1 |
Batlle, AM; Brown, EH; Butler, AR; Casas, A; MacRobert, A; Riley, PA; Robertson, D | 1 |
Jichlinski, P; Kucera, P; Lange, N; Marti, A; Sedmera, D; van den Bergh, H | 1 |
Al-Batran, SE; Astner, ST; Brueckner, K; Gamarra, F; Huber, RM; Knuechel, R; Supthut, M; Welsch, U | 1 |
Hahn, EG; Hochberger, J; Mayinger, B; Reh, H | 1 |
Carre, J; Eleouet, S; Heyman, D; Lajat, Y; Patrice, T; Rousset, N; Vonarx, V | 1 |
Csik, G; Fidy, J; Gabor, F; Szocs, K | 1 |
Baumgartner, R; Hofstetter, A; Knuechel, R; Kriegmair, M; Zaak, D | 1 |
Dietel, W; Günzel, S; Schleier, P; Zenk, W | 1 |
Gibson, SL; Havens, JJ; Hilf, R | 1 |
Ackroyd, R; Brown, N; Marcus, S; Reed, M; Roberts, D; Stephenson, T; Stoddard, C; Vernon, D | 1 |
Berg, K; Gadmar, OB; Iani, V; Juzenas, P; Ma, L; Moan, J | 1 |
Barbarin, A; Gibson, SL; Havens, JJ; Hilf, R; Nguyen, ML | 1 |
Edwards, BF; Griffey, SM; Krasieva, TB; Lucroy, MD; Madewell, BR; Peavy, GM; Stiles, JB | 1 |
Anderson, LT; Gibson, SL; Havens, JJ; Hilf, R | 1 |
af Klinteberg, C; Andersson-Engels, S; Canti, G; Cubeddu, R; Eker, C; Pifferi, A; Svanberg, K; Svanberg, S; Taroni, P; Valentini, G; Wang, I | 1 |
Arbogast, S; Baumgartner, R; Betz, CS; Grevers, G; Leunig, A; Mehlmann, M; Stepp, H | 1 |
Bentley, MV; De Rosa, FS; Marchetti, JM; Tedesco, AC; Thomazini, JA | 1 |
Böhm, J; Gahlen, J; Herfarth, C; Holle, R; Pressmar, J; Stern, J | 1 |
Juillerat-Jeanneret, L; Lange, N; Uehlinger, P; van den Bergh, H; Wagnières, G; Zellweger, M | 1 |
Grimm, B; Mock, HP; Papenbrock, J; Pfündel, E | 1 |
Egger, NG; Flores, P; Fossum, TW; Jacques, SL; Motamedi, M; Rastegar, S; Vaidyanathan, VV; van Der Breggen, EW | 1 |
Carré, J; Eléouet, S; Lajat, Y; Louët, C; Patrice, T; Rousset, N; Vilatte, C; Vonarx, V | 1 |
Ala-Opas, M; Alhava, E; Grönlund-Pakkanen, S; Kosma, VM; Pakkanen, TM; Talja, M | 1 |
Wang, KK | 1 |
Barr, H | 1 |
Messmann, H | 1 |
Hirschberg, H; Madsen, SJ; Sun, CH; Tromberg, BJ; Wallace, VP | 1 |
Haik, J; Kostenich, G; Malik, Z; Orenstein, A; Tamir, J; Trau, H; Winkler, E | 1 |
Allman, R; Cowburn, P; Mason, M | 1 |
de Rooij, FW; Edixhoven, A; Hinnen, P; Siersema, PD; Terlouw, EM; Tilanus, HW; van Dekken, H; van Hillegersberg, R; Wilson, JH | 1 |
Bagdonas, S; Iani, V; Juzenas, P; Ma, LW; Moan, J; Rotomskis, R | 1 |
Birkel, M; Popken, G; Schultze-Seemann, W; Seiler, KU; Wetterauer, U | 1 |
Belicková, M; Brdicka, R; Bruchová, H; Cajthamlová, H; Hrkal, Z | 1 |
Beijersbergen van Henegouwen, GM; de Bruijn, HS; Star, WM; Sterenborg, HJ; van den Akker, JT | 1 |
Baumgartner, R; Betz, CS; Grevers, G; Issing, WJ; Leunig, A | 1 |
Lilge, L; Portnoy, M; Wilson, BC | 1 |
Matthews, EK; Mesenhöller, M | 1 |
Brown, SB; Connelly, JP; Gerscher, S; Griffiths, J; MacRobert, AJ; Rhodes, LE; Wong, G | 1 |
Bartosová, J; Hrkal, Z | 1 |
Battah, SH; Boyle, RW; Edwards, C; Forsyth, MJ; Matthews, EK; Whitaker, CJ | 1 |
Edixhoven-Bosdijk, A; Siersema, PD; van Den Boogert, J; van Hillegersberg, R; van Staveren, HJ | 1 |
Frimberger, D; Hofstetter, A; Zaak, D | 1 |
Iani, V; Moan, J; Star, WM; Sterenborg, HJ; van den Akker, JT | 2 |
Berger, Y; Greppi, A; Juillerat-Jeanneret, L; Neier, R; Siri, O | 1 |
Beger, HG; Orth, K; Russ, D; Steiner, R | 1 |
de Bruijn, HS; de Wolf, WJ; Robinson, DJ; Star, WM; Sterenborg, HJ | 1 |
Conover, DL; Finlay, JC; Foster, TH; Hull, EL | 1 |
Manohara, MS; Tripathy, BC | 1 |
Bown, SG; Curnow, A; Haller, JC | 1 |
Iani, V; Ma, LW; Moan, J | 1 |
Klein, SD; Ladner, DP; Steiner, RA; Walt, H | 1 |
Dubois, J; Duez, P; Hanocq, M | 1 |
Killig, F; Kunz, L; Stark, G | 1 |
Bezdetnaya, L; Cosserat-Gerardin, I; Guillemin, F; Notter, D; Vigneron, C | 1 |
Appel, S; Baumgartner, R; Knuechel, R; Krieg, RC; Rauch, J; Seidl, J | 1 |
Beijersbergen Van Henegouwen, GM; Connelly, JP; Gerscher, S; MacRobert, AJ; Rhodes, LE; Watt, P | 1 |
Etter, AL; Gerber, P; Jichlinski, P; Kucera, P; Lange, N; Marti, A; van Den Bergh, H; Vaucher, L | 1 |
Arbogast, S; Baumgartner, R; Betz, C; Grevers, G; Leunig, A; Mehlmann, M; Stepp, H | 1 |
Eggen, I; Luksiene, Z; Moan, J; Nesland, JM; Peng, Q | 1 |
Arkins, S; Durack, G; Kelley, KW; Rebeiz, CA; Rebeiz, N | 1 |
Hashimoto, K; Li, W; Ohnishi, K; Ohno, R; Yamada, I; Zhang, WJ | 1 |
Bagdonas, S; Ma, L; Moan, J | 1 |
Dickson, EF; Fischer, F; Pottier, RH; Wieland, H | 1 |
Dickson, EF; Fischer, F; Kennedy, JC; Pottier, RH | 1 |
de Blois, AW; de Bruijn, HS; Dutrieux, RP; Grouls, RJ; Neumann, HA; Robinson, DJ; Thissen, MR | 1 |
Bagdonas, S; Iani, V; Juzenas, P; Moan, J; Rotomskis, R | 1 |
de Bruin, RW; Siersema, PD; van den Boogert, J; van Hillegersberg, R; van Staveren, HJ | 1 |
Bigelow, CE; Foster, TH; Knuechel, R; Mitra, S | 1 |
Ishibashi, A; Itoh, Y; Ninomiya, Y; Tajima, S | 1 |
Berg, K; Kaalhus, O; Selbo, PK; Sivam, G | 1 |
Aalders, MC; Star, WM; Sterenborg, HJ; van der Vange, N | 1 |
Bissonnette, R; Korbelik, M; Lui, H; McLean, DI; Zeng, H | 1 |
Baumgartner, R; Frimberger, D; Hofstetter, A; Knüchel, R; Schmeller, N; Schneede, P; Stepp, H; Zaak, D | 1 |
Flechtenmacher, C; Gahlen, J; Herfarth, C; Prosst, RL; Winkler, S | 1 |
Hahn, EG; Martus, P; Mayinger, B; Neidhardt, S; Reh, H | 1 |
Baumgartner, R; Hillemanns, P; Klein, S; Liessmann, F; Stepp, H; Weingandt, H; Xiang, W | 1 |
Chai, SE; Choi, HY; Hong, JH; Jeon, SS; Kang, I | 1 |
Chopra, V; Dreher, E; Egger, N; Hawkins, HK; Motamedi, M; Schneider, H; Spörri, S | 1 |
Endlicher, E; Hausmann, F; Knüchel, R; Krieg, R; Messmann, H; Rath, HC; Rümmele, P; Schölmerich, J | 1 |
Brunner, H; Endlicher, E; Hausmann, F; Knuechel, R; Krieg, RC; Messmann, H; Schölmerich, J | 1 |
Chen, JY; Cheung, NH; Leung, RN; Mak, NQ; Peng, Q | 1 |
Batlle, A; Butler, AR; Casas, A; Fukuda, H; Perotti, C; Rogers, L | 1 |
Kaneko, S | 1 |
Arbogast, S; Baumgartner, R; Betz, CS; Grevers, G; Janda, P; Leunig, A; Stepp, H | 1 |
Iani, V; Juzenas, P; Löfgren, L; Ma, LW; Moan, J; von Beckerath, M | 1 |
Gahlen, J; Haase, T; Herfarth, C; Pietschmann, M; Prosst, RL; Rheinwald, M; Skopp, G; Stern, J | 1 |
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de Bruijn, HS; Robinson, DJ; Sterenborg, HJ; van der Ploeg-van den Heuvel, A | 1 |
de Haas, ER; Munte, K; Robinson, DJ; Star, WM; Sterenborg, HJ; van't Veen, AJ | 1 |
Heng, PW; Manivasager, V; Olivo, M; Soo, KC; Yee, KK | 1 |
Iani, V; Juzenas, P; Juzeniene, A; Ma, LW; Moan, J | 1 |
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Chen, B; Kraus, D; Palasuberniam, P; Yang, X | 1 |
Dirschka, T; Hoeh, AK; Luebbert, H; Novak, B; Schmitz, L | 1 |
Cohen, R; Morohaku, K; Mukai, C; Pillai, VV; Selvaraj, V; Sirivelu, MP; Tu, LN; Zhao, AH | 1 |
Aalders, MC; Bergman, JJ; Boerwinkel, DF; Holz, JA; Meijer, SL; van Leeuwen, TG; Visser, M | 1 |
Fujino, M; Ito, H; Li, XK; Nishio, Y; Tanaka, T | 1 |
Belton, RJ; Lawrence, JE; Rovin, RA; Steele, CJ; Winn, RJ | 1 |
Bay, C; Haedersdal, M; Lerche, CM; Togsverd-Bo, K | 1 |
Bosseila, M; El Hoshy, K; El Sharkawy, D; Sobhi, R | 1 |
Harada, Y; Koizumi, N; Minamikawa, T; Otsuji, E; Takamatsu, T; Tanaka, H | 1 |
Elenbaas, JS; Hoenerhoff, MJ; Lentz, SI; Liu, Y; Maitra, D; Nelson, B; Omary, MB; Shavit, JA | 1 |
Clowry, J; Collins, P; Gray, L; Kavanagh, A; Lally, A; Manley, M; McCavana, J; O'Gorman, SM | 1 |
Asakura, T; Higuchi, T; Hu, S; Ju, D; Morita, A; Orimo, H; Yamaguchi, F; Zhan, G | 1 |
Nissen, CV; Philipsen, PA; Wiegell, SR; Wulf, HC | 1 |
Brooks, S; de Bruijn, HS; de Haas, ER; Robinson, DJ; Ten Hagen, TL; van der Ploeg-van den Heuvel, A | 1 |
Christiansen, K; Erlendsson, AM; Haak, CS; Haedersdal, M; Taudorf, EH; Thaysen-Petersen, D; Wulf, HC | 1 |
Beika, M; Dai, P; Harada, Y; Koizumi, N; Minamikawa, T; Murayama, Y; Otsuji, E; Takamatsu, T; Tanaka, H; Yamaoka, Y; Yanagisawa, A | 1 |
Harada, Y; Kato, Y; Matsuo, H; Minamikawa, T; Otsuji, E; Takamatsu, T; Tanaka, H; Yanagisawa, A | 1 |
Cui, X; Fan, Z; He, H; Li, B; Liu, W; Wei, D; Wei, X; Ye, H; Zhu, N | 1 |
Babes, A; Filipovic, M; Fischer, MJ; Kichko, TI; Moparthi, L; Namer, B; Neacsu, C; Reeh, PW; Sauer, SK; Zygmunt, PM | 1 |
Lopez, N; Mulet, R; Rodríguez, R | 1 |
Allémann, E; Ateb, I; Babič, A; Herceg, V; Lange, N | 1 |
Chen, J; Wang, B; Wang, P; Wang, X; Zhang, G; Zhang, Y | 1 |
Curnow, A; Dodd, NJF; Dogra, Y; Ferguson, DCJ; Smerdon, GR; Winyard, PG | 1 |
Ma, R; Watts, C | 1 |
Chapman, MS; Davis, SC; de Souza, AL; Gunn, J; Hasan, T; Kanick, SC; Marra, K; Maytin, EV; Pogue, BW; Samkoe, KS | 1 |
Ebbert, L; Etminan, N; Ewelt, C; Finocchiaro, G; Fischer, JC; Lamszus, K; Sabel, MC; Schimanski, A; Sorg, RV | 1 |
Fujiwara, H; Harada, K; Ichikawa, D; Ikoma, H; Kamada, Y; Morimura, R; Murayama, Y; Nishimura, M; Okamoto, K; Otsuji, E | 1 |
Goryaynov, SA; Panteleev, D; Pavlova, G; Potapov, AA; Pustogarov, N; Revishchin, A; Ryabova, AV; Rybalkina, EY | 1 |
Bechara, EJ; Correa, L; Goulart, VP; Lima, CA; Zezell, DM | 1 |
Ji, J; Jin, Q; Li, H; Lin, Y; Wu, J | 1 |
Heerfordt, IM; Mikkelsen, CS; Nissen, CV; Wiegell, SR; Wulf, HC | 1 |
Clear, KJ; Harmatys, KM; Musso, AJ; Smith, BD | 1 |
Bae, SJ; Berezin, V; Kang, U; Lee, DS; Lee, KH | 1 |
Lu, Y; Wang, H; Ye, X; Yin, H; Zhang, H | 1 |
Fahey, JM; Girotti, AW; Korytowski, W | 1 |
Bowling, J; Campbell, S; Ibbotson, S; Kownacki, S; Morton, CA; Sivaramakrishnan, M; Stones, R; Valentine, R | 1 |
Abe, M; Adachi, K; Hasegawa, M; Hayashi, T; Hirose, Y; Inamasu, J; Kumon, M; Murayama, K; Nagahisa, S; Nakae, S; Nishiyama, Y; Ohba, S; Sasaki, H | 1 |
Hagiya, Y; Inoue, K; Kobayashi, T; Matsumoto, K; Nakajima, M; Nakayama, T; Ogura, SI; Okajima, H; Otsuka, S; Shuin, T; Tanaka, T | 1 |
Cheng, J; Dong, Z; Guo, Y; Li, Z; Shi, Y; Sun, J; Sun, X; Tian, Y; Tian, Z; Wang, L; Wang, W; Yao, J | 1 |
Bouvier, G; Comby, P; Gaborit, A; Hanaizi, J; Kouidhi, M; Osman-Ponchet, H; Ruty, B; Sevin, K | 1 |
Bettink, MAW; Harms, FA; Janse, R; Johannes, T; Mik, EG; Münker, FM; Ubbink, R | 1 |
Gerelli, E; Joniová, J; Wagnières, G; Zellweger, M | 1 |
Fahey, JM; Girotti, AW | 1 |
Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J | 1 |
Dailey, HA; Dailey, TA; Gerdes, S; Jahn, D; Jahn, M; O'Brian, MR; Warren, MJ | 1 |
Bay, C; Ferrick, B; Haedersdal, M; Lerche, CM; Philipsen, PA; Togsverd-Bo, K | 1 |
Inoue, K | 1 |
Bierman, D; Gandy, J; Labadie, B; Zachary, C | 1 |
Borwege, S; Chen, Y; Liu, JTC; Sanai, N; Wei, L; Yin, C | 1 |
Allémann, E; Babič, A; Herceg, V; Lange, N | 1 |
Arenas, FA; Cornejo, FA; Luraschi, R; Morales, EH; Mori, H; Muñoz-Villagrán, CM; Myers, CL; Nelson, J; Pinto, CA; Piotrowski, JS; Simpkins, SW; Vásquez, CC | 1 |
Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE | 1 |
Hamblin, MR; Li, Y; Wen, X | 1 |
Kawahara, R; Kawakami, Y; Matsumoto, T; Nagano, N; Nagata, M; Nakaya, H; Nishizawa, T; Oana, K | 1 |
Chen, Y; Eubanks, JH; Fisher, CJ; Foltz, W; Lilge, L; Niu, C; Sidorova-Darmos, E | 1 |
Bravo, JJ; Davis, SC; Kanick, SC; Olson, JD; Paulsen, KD; Roberts, DW | 1 |
Ding, C; Fan, D; Ji, Z; Kang, Q; Liu, J; Ning, S; Peng, Q; Xue, C; Zhang, J; Zhang, X | 1 |
Chen, ZL; Gao, YH; Han, YP; Lu, ZB; Namulinda, T; Song, CH; Wang, LX; Yan, YJ; Zhu, W | 1 |
Furuse, M; Ikeda, N; Kajimoto, Y; Katayama, Y; Kawabata, S; Kuroiwa, T; Nonoguchi, N; Yagi, R | 1 |
Chapman, MS; Davis, SC; de Souza, ALR; Gunn, J; Hasan, T; LaRochelle, E; Marra, K; Maytin, EV; Pogue, BW; Samkoe, KS | 1 |
Akter, S; Awazu, K; Fuse, S; Hazama, H; Honda, N; Inai, M; Kaneda, Y; Nakamura, H; Nishikawa, T | 1 |
Collins, P; Gray, L; Manley, M; McCavana, J; O'Gorman, S | 1 |
Heerfordt, IM; Wulf, HC | 1 |
Ishii, T; Ishizuka, M; Kajiyama, H; Kikkawa, F; Kitajima, Y; Mizuno, M; Sakata, J; Shibata, K; Teshigawara, T; Utsumi, F | 1 |
Falco, A; Mallavia, R; Mateo, CR; Mira, A | 1 |
Corrêa, L; Pelissari, C; Rosin, FCP; Teixeira, MG | 1 |
Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM | 1 |
Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC | 1 |
Iwahashi, H; Mori, T; Murakami, M; Takahashi, J | 1 |
Christensen, E; Darvekar, SR; Gederaas, OA; Holien, T; Peng, Q | 1 |
Bieliauskiene, G; Heerfordt, IM; Wulf, HC | 1 |
Anai, S; Fujimoto, K; Hori, S; Miyake, M; Morizawa, Y; Nakai, Y; Onisi, S; Tanaka, N; Tatsumi, Y | 1 |
Barlier, C; Bezdetnaya, L; Dolivet, G; Francois, A; Leufflen, L; Marchal, F; Salleron, J | 1 |
Cao, W; Cao, Z; Cheng, J; Dan, J; Guo, S; Sun, X; Tian, F; Tian, Y; Wang, W | 1 |
Dong, X; Fan, JX; Liu, XH; Pan, P; Xu, L; Zhang, XZ; Zheng, DW | 1 |
Bánó, G; Gerelli, E; Joniová, J; Kažiková, V; Wagnières, G | 1 |
Wang, B; Wang, P; Wang, X; Wu, Y; Zhang, L | 1 |
Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J | 1 |
Belykh, E; Bozkurt, B; Lawton, MT; Miller, EJ; Nakaji, P; Nelson, LY; Patel, AA; Preul, MC; Robinson, TR; Seibel, EJ; Spetzler, RF; Yağmurlu, K | 1 |
Friebe, M; Goeppner, D; Gollnick, H; Illanes, A; Landes, R | 1 |
Aoki, D; Banno, K; Kisu, I; Matoba, Y | 1 |
Jeibmann, A; Karst, U; Kröger, S; Niehoff, AC; Paulus, W; Sperling, M; Stummer, W | 1 |
Alston, L; Hebert, M; Mahieu-Williame, L; Montcel, B; Rousseau, D | 1 |
Backeris, P; Bishop, DF; D'Souza, S; Desnick, RJ; Katz, S; Lemischka, IR; Merck, C; Moore, K; Suprun, M; Ubarretxena-Belandia, I | 1 |
Fujita, H; Masujima, T; Mizuno, H; Oka, T; Sakata, M; Utsumi, K; Utsunomiya, A; Yamano, Y; Yoshino, T | 1 |
Hou, G; Ji, L; Qian, J; Suo, A; Wang, J; Wang, Y; Xu, W; Yang, M | 1 |
Beez, T; Briel-Pump, A; Ebbert, L; Remke, M; Sabel, MC; Sorg, RV; Weinhold, S | 1 |
Curnow, A; Perry, A; Wood, M | 1 |
Chen, L; Gao, L; Gao, X; Huang, X; Li, N; Lin, S; Song, Y; Wang, X; Zhang, X | 1 |
Cooper, JB; Endo, T; Schmidt, MH; Tominaga, T; Wainwright, JV | 1 |
Millesi, M; Roberts, DW; Valdes, PA; Widhalm, G | 1 |
Fujimoto, K; Hiroyuki, N; Matsuda, R; Motoyama, Y; Murakami, T; Nakagawa, I; Nakai, Y; Nakamura, M; Nakazawa, T; Nishimura, F; Omoto, K; Shida, Y; Tanaka, Y; Tatsumi, Y | 1 |
He, Q; He, W; Liu, P; Ren, J; Wang, J; Xiong, Y; Xu, Z; Yang, Z; Zhu, W | 1 |
Braun, A; Chen, B; Howley, R; Kraus, D; Mansi, M; Myers, KA; Palasuberniam, P | 1 |
Carrasco, E; Damian, A; Delgado-Wicke, P; Juarranz, Á; Lucena, SR; Mascaraque, M | 1 |
Wulf, HC | 1 |
Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N | 1 |
Ebihara, Y; Hirano, S; Hirohashi, Y; Kanaseki, T; Kawai, N; Kubo, T; Li, L; Murai, A; Nakatsugawa, M; Saito, T; Shichinohe, T; Shirosaki, T; Torigoe, T; Tsukahara, T | 1 |
Kaneko, S; Stummer, W; Suero Molina, E | 1 |
Buchner, A; Gederaas, OA; Pohla, H; Pongratz, T; Rühm, A; Shi, L; Sroka, R; Stepp, H; Wang, X; Zhang, L; Zimmermann, W | 1 |
Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H | 1 |
Dan, S; Ishii, T; Ishizuka, M; Kitajima, Y; Kohda, T; Nakajima, M; Nishimura, Y; Tanaka, T; Yamazaki, K | 1 |
Lai, HW; Nakajima, M; Ogura, SI; Sasaki, R; Tanaka, T; Usuki, S | 1 |
Champeau, M; Mordon, S; Mortier, L; Vignoud, S | 1 |
Cornelius, JF; Dibué-Adjei, M; Kamp, MA; Knipps, J; Mijderwijk, HJ; Neumann, LM; Rapp, M; Sabel, M; Slotty, PJ; Steiger, HJ | 1 |
Cornelius, JF; Dibué-Adjei, M; Fischer, I; Freiin von Saß, C; Kamp, MA; Knipps, J; Mijderwijk, HJ; Neumann, LM; Placke, JM; Rapp, M; Sabel, M; Steiger, HJ | 1 |
Harada, Y; Kumamoto, Y; Morita, M; Nakamura, A; Ogata, T; Sakaguchi, K; Taguchi, T; Takamatsu, T; Tanaka, H | 1 |
Chan, KM; Gleadle, J; Li, J; MacGregor, M; McNicholas, K; Shirazi, HS; Vasilev, K | 1 |
Gleadle, JM; MacGregor, MN; McNicholas, K | 1 |
Brentrup, A; Kaneko, S; Köchling, M; Müther, M; Schipmann, S; Schwake, M; Stummer, W; Suero Molina, E | 1 |
Gawecki, R; Malarz, K; Mrozek-Wilczkiewicz, A; Polanski, J; Rejmund, M | 1 |
Ishizuka, M; Okamoto, Y; Osaki, T; Takahashi, K; Tanaka, T | 1 |
Bagnato, VS; Fortunato, TC; Pratavieira, S; Requena, MB; Russignoli, PE; Salvio, AG; Vollet-Filho, JD | 1 |
Burgio, F; D'Angelo, ML; Kaelin-Lang, A; Paganetti, P; Piffaretti, D; Reinert, M; Thelen, M | 1 |
Bilmin, K; Grieb, P; Kujawska, T | 1 |
Chapman, MS; Gunn, JR; Hasan, T; Hull, SM; LaRochelle, EPM; Pogue, BW; Ruiz, AJ | 1 |
Maliszewska, I; Wanarska, E; Wawrzyńczyk, D | 1 |
Alston, L; Brevet, PF; Frindel, C; Guyotat, J; Leclerc, P; Mahieu-Williame, L; Meyronet, D; Montcel, B; Ray, C; Rousseau, D | 1 |
Foged, C; Haedersdal, M; Philipsen, PA; Togsverd-Bo, K; Wulf, HC | 1 |
Jeibmann, A; Stögbauer, L; Stummer, W; Suero Molina, E; Warneke, N | 1 |
Harada, Y; Koshiishi, N; Matsumoto, T; Matsuo, H; Murayama, Y; Okochi, K; Otsuji, E; Takamatsu, T; Tanaka, H | 1 |
Awazu, K; Hazama, H; Ihara, D; Morita, Y; Nishimura, T | 1 |
Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J | 1 |
Doi, M; Hasegawa, T; Iwahashi, H; Moriyama, A; Nagasawa, S; Takahashi, J | 1 |
Asakura, T; Higuchi, T; Morita, A; Oishi, Y; Yamaguchi, F; Yoshida, D | 1 |
Chan, KM; Gleadle, J; MacGregor, M; Vasilev, K | 1 |
Bagnato, VS; Moriyama, LT; Stringasci, MD; Vollet-Filho, JD | 1 |
Chu, ESM; Wu, RWK; Yow, CMN | 1 |
Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N | 1 |
Brebi, P; Buchegger, K; Ili, C; Kurachi, C; León, D; Mora-Lagos, B; Riquelme, I; Roa, JC; Schafer, F; Silva, R; Viscarra, T; Zanella, L | 1 |
Imanparast, A; Sazgarnia, A; Shayesteh Ara, E; Soudmand, S; Vejdani Noghreiyan, A; Vejdani Noghreiyan, V | 1 |
Jang, W-; Jung, S; Jung, T-; Kim, I-; Kim, J-; Kim, S-; Lee, K-; Moon, K- | 1 |
Champeau, M; Jary, D; Mordon, S; Mortier, L; Vignoud, S | 1 |
Abdel Gaber, SA; Müller, P; Stepp, H; Wittig, R; Zimmermann, W | 1 |
Lai, HW; Nakayama, T; Ogura, SI | 1 |
Chen, B; Howley, R; Mansi, M; Restrepo, J; Shinde, J | 2 |
Bagnato, VS; De Faria, CMG; Donnelly, RF; Garcia, MR; González-Vázquez, P; Permana, AD; Pratavieira, S; Requena, MB; Vollet-Filho, JD | 1 |
Cumberbatch, N; Holland, A; Hungerford, G; Sagoo, K | 1 |
Bik, L; Dierickx, C; Foged, C; Haedersdal, M; Phillipsen, PA; Togsverd-Bo, K | 1 |
Čunderlíková, B; Jerigová, M; Kalafutová, A; Teplický, T | 1 |
Bagnato, VS; Buzza, HH; Ciol, H; Inada, NM; Leite, IS; Romano, RA; Stringasci, MD | 1 |
Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A | 1 |
Bardonova, L; Belykh, E; Eschbacher, JM; George, LL; Georges, JF; Healey, DR; Jubran, JH; Mehta, S; Nakaji, P; Preul, MC; Quarles, CC; Scheck, AC | 1 |
Dondi, R; Eggleston, IM; MacRobert, AJ; Pourzand, C; Tewari, KM; Yaghini, E | 1 |
Borowska, K; Kaczorowska, A; Kałas, W; Kopaczyńska, M; Malinga-Drozd, M; Wołowiec, S | 1 |
Awazu, K; Hazama, H; Ogbonna, SJ | 1 |
Chan, KM; Gleadle, J; Li, J; MacGregor, M; Michl, TD; Vasilev, K | 1 |
Lai, HW; Nakajima, M; Ogura, SI; Takahashi, K; Tanaka, T | 1 |
Courrol, LC; de Oliveira Silva, FR; Masilamani, V | 1 |
Banerjee, R; Maitra, D; Omary, MB; Pinsky, BM; Soherawardy, A; Zheng, H | 1 |
Harms, FA; Mik, EG | 1 |
Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E | 1 |
Curnow, A; Magnussen, A; Perry, A; Reburn, C; Wood, M | 1 |
Fujihara, T; Fujiwara, Y; Kitazato, K; Matsuzaki, K; Mizobuchi, Y; Nakajima, K; Sampetrean, O; Saya, H; Shono, K; Takagi, Y; Uto, Y; Yamaguchi, I | 1 |
Chen, Q; Cheng, Y; He, H; Huang, P; Li, Y; Wei, W; Xiong, L; Yi, W; Zeng, L; Zou, Q | 1 |
Ashraf, S; Feng, Y; Hasan, T; Khalid, A; Kuriakose, J; Palanisami, A | 1 |
Essmann, F; Gillissen, B; Kemmner, W; Richter, A | 1 |
Agyapong, J; Ashraf, S; Hasan, T; Rohrbach, P | 1 |
Braun, A; Chen, B; Howley, R; Kraus, D; Mansi, M; Myers, K; Palasuberniam, P | 1 |
Basoglu, H; Degirmencioglu, I; Eyupoglu, FC | 1 |
Ferreira, I; Fontana, LC; Mamone, LA; Pacheco-Soares, C; Pinto, JG; Strixino, JF; Vitorio, GDS | 1 |
Chen, B; Howley, R; Mansi, M | 1 |
Alfonso-García, A; Anbunesan, SN; Bec, J; Bloch, O; Fereidouni, F; Jin, LW; Lee, HS; Marcu, L; Zhou, X | 1 |
Chandratre, S; Chen, B; Howley, R; Mansi, M | 1 |
Harada, Y; Murayama, Y; Otsuji, E; Takamatsu, T; Tanaka, H | 1 |
Kämper, L; Lübbert, H; Novak, B; Schary, N; Yousf, A | 1 |
Kiening, M; Lange, N | 1 |
Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H | 1 |
Bruza, P; Pétusseau, A; Pogue, B | 1 |
Chen, Y; Deng, H; Feng, M; Guo, L; Yang, L | 1 |
Awazu, K; Fukuhara, H; Hazama, H; Inoue, K; Nishimura, T; Ogbonna, SJ; York, WY | 1 |
Bietar, K; Capobianco, JA; Mandl, GA; Maurizio, SL; Stochaj, U; Tessitore, G; Vettier, F | 1 |
Fukuda, Y; Grace, CR; Kavdia, K; Li, Y; Lynch, J; Peng, J; Ranjit, S; Robinson, CG; Schuetz, JD; Wang, Y; Xia, Y | 1 |
Kiesel, B; Lang, A; Millesi, M; Mischkulnig, M; Traxler, D; Wadiura, LI; Widhalm, G | 1 |
56 review(s) available for protoporphyrin ix and aminolevulinic acid
Article | Year |
---|---|
Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Photochemotherapy; Prodrugs; Protoporphyrins | 1992 |
Photodynamic therapy of primary skin cancer: a review.
Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents; Bowen's Disease; Carcinoma, Basal Cell; Female; Follow-Up Studies; Hematoporphyrin Derivative; Humans; Lasers; Photochemotherapy; Protoporphyrins; Skin Neoplasms | 1995 |
[Porphyrin biosynthetic pathway and its regulation].
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Erythrocytes; Heme; Liver; Porphyrins; Protoporphyrins | 1995 |
[Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria].
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Porphyrias; Porphyrins; Protoporphyrins | 1995 |
Possible benefits of two-quantum excitation in ALA-PDT?
Topics: Aminolevulinic Acid; Animals; Humans; Light; Photochemotherapy; Porphyrins; Protoporphyrins; Quantum Theory; Tumor Cells, Cultured | 1994 |
The regulation of enzymes involved in chlorophyll biosynthesis.
Topics: Amino Acid Sequence; Aminolevulinic Acid; Chlorophyll; Chloroplasts; Gene Expression Regulation, Plant; Molecular Sequence Data; Molecular Structure; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Photosynthesis; Plants; Protochlorophyllide; Protoporphyrins; Pyrroles; Sequence Homology, Amino Acid; Tetrapyrroles | 1996 |
5-Aminolevulinic acid-based photodynamic therapy: principles and experimental research.
Topics: Aminolevulinic Acid; Animals; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 1997 |
5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges.
Topics: Aminolevulinic Acid; Forecasting; Heme; Humans; Neoplasms; Photochemotherapy; Protoporphyrins; Research; Skin Diseases; Skin Neoplasms | 1997 |
Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): current clinical and development status.
Topics: Aminolevulinic Acid; Animals; Endometrium; Female; Gastrointestinal Neoplasms; Humans; Laser Therapy; Neoplasms; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Urinary Bladder Diseases | 1996 |
Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): mechanisms and clinical results.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Humans; Photosensitizing Agents; Protoporphyrins | 1996 |
Photodynamic therapy of Barrett's esophagus.
Topics: Aminolevulinic Acid; Barrett Esophagus; Esophagoscopy; Fiber Optic Technology; Hematoporphyrin Derivative; Humans; Injections, Intravenous; Laser Therapy; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2000 |
Barrett's esophagus: treatment with 5-aminolevulinic acid photodynamic therapy.
Topics: Aminolevulinic Acid; Barrett Esophagus; Esophagoscopy; Humans; Injections, Intravenous; Intestinal Mucosa; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment Outcome | 2000 |
5-Aminolevulinic acid-induced protoporphyrin IX for the detection of gastrointestinal dysplasia.
Topics: Aminolevulinic Acid; Animals; Endoscopy, Gastrointestinal; Gastrointestinal Neoplasms; Humans; Intestinal Mucosa; Photosensitizing Agents; Precancerous Conditions; Prognosis; Protoporphyrins; Spectrometry, Fluorescence | 2000 |
Endoscopic fluorescence diagnosis and laser treatment of transitional cell carcinoma of the bladder.
Topics: Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopy; Fluorescence; Humans; Laser Therapy; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms | 2000 |
[Intraoperative photodynamic diagnosis of human glioma using ALA induced protoporphyrin IX].
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Male; Mice; Middle Aged; Monitoring, Intraoperative; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity | 2001 |
On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation.
Topics: Aminolevulinic Acid; Animals; Hematoporphyrin Photoradiation; Heme; Humans; Molecular Structure; Neoplasms; Photosensitizing Agents; Protoporphyrins | 2004 |
[Fluorescence imaging technique: diagnostic and therapeutic interest in gynecology].
Topics: Aminolevulinic Acid; Breast Neoplasms; Female; Genital Diseases, Female; Gynecology; Humans; Neoplasms; Ovarian Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Uterine Cervical Neoplasms; Uterine Diseases; Vaginal Diseases; Vulvar Diseases | 2004 |
[Intraoperative photodynamic diagnosis using 5-ALA for glioma surgery].
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Monitoring, Intraoperative; Neoplasm, Residual; Neurosurgical Procedures; Photofluorography; Photosensitizing Agents; Protoporphyrins | 2005 |
[Fluorescence diagnosis in dermatology].
Topics: Aminolevulinic Acid; Image Processing, Computer-Assisted; Optical Imaging; Protoporphyrins; Skin Diseases; Skin Neoplasms | 2003 |
Use of ALA and ALA derivatives for optimizing ALA-based photodynamic therapy: a review of our experience.
Topics: Aminolevulinic Acid; Animals; Esterases; Heme; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2006 |
Repetitive photodynamic therapy of malignant brain tumors.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spheroids, Cellular | 2006 |
Photodynamic therapies: principles and present medical applications.
Topics: Aminolevulinic Acid; Bowen's Disease; Clinical Trials as Topic; Humans; Light; Lipoproteins, LDL; Male; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Diseases; Skin Neoplasms | 2006 |
[Fluorescence diagnosis and photodynamic therapy with 5-aminolevulinic acid induced protoporphyrin IX in gynecology: an overview].
Topics: Aminolevulinic Acid; Endometrial Neoplasms; Female; Genital Diseases, Female; Humans; Laparoscopy; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins | 2006 |
["... The better to see you with"--phothodynamic diagnostic in superficial bladder cancer].
Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Carcinoma in Situ; Carcinoma, Papillary; Clinical Trials, Phase III as Topic; Cystoscopy; Disease Models, Animal; Fluorescence; Follow-Up Studies; Humans; Neoplasm Recurrence, Local; Photosensitizing Agents; Prospective Studies; Protoporphyrins; Randomized Controlled Trials as Topic; Rats; Reoperation; Sensitivity and Specificity; Time Factors; Urinary Bladder Neoplasms | 2007 |
ALA and its clinical impact, from bench to bedside.
Topics: Aminolevulinic Acid; Dendritic Cells; Fluorescence; Humans; Keratosis; Lymphocytes; Macrophages; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity | 2008 |
Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Humans; Keratosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2009 |
New aspects in photodynamic therapy of actinic keratoses.
Topics: Aminolevulinic Acid; Humans; Keratosis, Actinic; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2009 |
[Intraoperative photo-dynamic diagnosis of brain tumors].
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperative Period; Meningeal Neoplasms; Meningioma; Microsurgery; Neurosurgical Procedures; Protoporphyrins; Surgery, Computer-Assisted; Ultraviolet Rays | 2009 |
[Fluorescence diagnosis of non-melanoma skin cancer].
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Squamous Cell; Cell Proliferation; Cold Temperature; Fluorescence; Humans; Mohs Surgery; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Skin Neoplasms; Treatment Outcome | 2012 |
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies.
Topics: Aminolevulinic Acid; Brain Neoplasms; Disease-Free Survival; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Neurosurgical Procedures; Photosensitizing Agents; Positron-Emission Tomography; Protoporphyrins; Randomized Controlled Trials as Topic; Surgery, Computer-Assisted | 2012 |
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted | 2012 |
[Surgery of high-grade gliomas guided by fluorescence: a retrospective study of 22 patients].
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Microscopy, Fluorescence; Microsurgery; Middle Aged; Neoplasm Grading; Neoplasm, Residual; Neovascularization, Pathologic; Neuronavigation; Neurosurgical Procedures; Prognosis; Protoporphyrins; Retrospective Studies; Surgery, Computer-Assisted | 2013 |
Innovations in the endoscopic management of bladder cancer: is the era of white light cystoscopy over.
Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Transitional Cell; Cystoscopy; False Negative Reactions; Female; Forecasting; Humans; Light; Male; Multimodal Imaging; Neoplasm Recurrence, Local; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Tomography, Optical Coherence; Tomography, X-Ray Computed; Urinary Bladder Neoplasms | 2013 |
5-Aminolevulinic acid-based fluorescence diagnostics of cervical preinvasive changes.
Topics: Aminolevulinic Acid; Female; Fluorescence; Humans; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2014 |
Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain tumor.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Brain Neoplasms; Gefitinib; Humans; Mice; Neoplasm Proteins; NF-E2-Related Factor 2; Oxidative Stress; Photochemotherapy; Porphyrins; Protein Kinase Inhibitors; Protoporphyrins; Quinazolines; Transcription, Genetic; Treatment Outcome | 2015 |
Fluorescence guided resection and glioblastoma in 2015: A review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted | 2015 |
5-Aminolevulinic Acid-Protoporphyrin IX Fluorescence-Guided Surgery of High-Grade Gliomas: A Systematic Review.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Microscopy, Fluorescence; Microsurgery; Neoplasm Grading; Neoplasm, Residual; Neuronavigation; Protoporphyrins; Sensitivity and Specificity; Statistics as Topic; Surgery, Computer-Assisted | 2016 |
Aminolevulinic Acid-Based Tumor Detection and Therapy: Molecular Mechanisms and Strategies for Enhancement.
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2015 |
5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction.
Topics: Aminolevulinic Acid; Heme; Heme Oxygenase-1; Histocompatibility; Humans; Immunity; Immunologic Factors; Inflammation; Macrophages; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction; Transplantation, Homologous | 2016 |
Recent advances in photodynamic diagnosis of gastric cancer using 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Biomarkers, Tumor; Humans; Intraoperative Care; Luminescent Measurements; Lymphatic Metastasis; Molecular Diagnostic Techniques; Peritoneal Neoplasms; Predictive Value of Tests; Protoporphyrins; Reproducibility of Results; Stomach Neoplasms | 2016 |
Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Neurons; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins | 2016 |
Multiple Means by Which Nitric Oxide can Antagonize Photodynamic Therapy.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Humans; Light; Neoplasms; Nitric Oxide; Nitric Oxide Synthase Type II; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2016 |
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.
Topics: Aminolevulinic Acid; Archaea; Bacteria; Coproporphyrinogen Oxidase; Coproporphyrins; Heme; Iron; Protoporphyrins; Tetrapyrroles; Uroporphyrinogen Decarboxylase | 2017 |
5-Aminolevulinic acid-mediated photodynamic therapy for bladder cancer.
Topics: Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment Outcome; Urinary Bladder; Urinary Bladder Neoplasms | 2017 |
Photodynamic therapy in dermatology beyond non-melanoma cancer: An update.
Topics: Acne Vulgaris; Aminolevulinic Acid; Collagen; Humans; Photochemotherapy; Photosensitizing Agents; Port-Wine Stain; Procollagen; Protoporphyrins; Psoriasis; Reactive Oxygen Species; Rejuvenation; Scleroderma, Localized; Skin; Skin Diseases; Skin Temperature; Warts | 2017 |
Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: A review.
Topics: Aminolevulinic Acid; Endometrial Neoplasms; Female; Genital Diseases, Female; Humans; Neoplasm Staging; Ovarian Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Remission Induction; Uterine Cervical Diseases | 2018 |
The role of 5-aminolevulinic acid in spinal tumor surgery: a review.
Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Optical Imaging; Protoporphyrins; Spinal Cord Neoplasms; Spinal Neoplasms; Surgery, Computer-Assisted | 2019 |
5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery.
Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Meningeal Neoplasms; Meningioma; Optical Imaging; Protoporphyrins; Surgery, Computer-Assisted | 2019 |
Photodynamic therapy for skin cancer: How to enhance drug penetration?
Topics: Aminolevulinic Acid; Drug Compounding; Humans; Liposomes; Micelles; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 2019 |
In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?
Topics: Amino Acid Transport Systems; Aminolevulinic Acid; Brain Neoplasms; Coproporphyrinogens; Ferrochelatase; Fluorescence; Glucose; Heme; Humans; Iron; MicroRNAs; Mitochondria; Mutation; NADP; Neoplasms; Oncogenes; Optical Imaging; Peptide Transporter 1; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Symporters; Tumor Hypoxia; Tumor Microenvironment; Urinary Bladder Neoplasms | 2019 |
Sonodynamic Therapy for Gliomas. Perspectives and Prospects of Selective Sonosensitization of Glioma Cells.
Topics: Aminolevulinic Acid; Animals; Diagnostic Imaging; Disease Models, Animal; Glioma; Humans; Light; Protoporphyrins; Ultrasonic Therapy; Ultrasonic Waves | 2019 |
5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Mitochondria; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Surgery, Computer-Assisted | 2020 |
Key transporters leading to specific protoporphyrin IX accumulation in cancer cell following administration of aminolevulinic acid in photodynamic therapy/diagnosis.
Topics: Aminolevulinic Acid; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2021 |
SARS-CoV-2, hemoglobin and protoporphyrin IX: Interactions and perspectives.
Topics: Aminolevulinic Acid; COVID-19 Drug Treatment; Hemoglobins; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; SARS-CoV-2 | 2021 |
5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Glioma; Heme; Humans; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiopharmaceuticals | 2022 |
A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells.
Topics: Aminolevulinic Acid; Animals; Heme; Iron; Mammals; Neoplasms; Porphyrins; Protoporphyrins | 2022 |
61 trial(s) available for protoporphyrin ix and aminolevulinic acid
Article | Year |
---|---|
Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Keratosis; Photochemotherapy; Prodrugs; Protoporphyrins; Radiation-Sensitizing Agents; Skin Neoplasms | 1990 |
Sensitization and photodynamic therapy (PDT) of gastrointestinal tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX). A pilot study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biotransformation; Female; Gastrointestinal Neoplasms; Humans; Male; Microscopy, Fluorescence; Middle Aged; Photochemotherapy; Pilot Projects; Protoporphyrins; Tissue Distribution | 1995 |
Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid.
Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cystoscopy; Female; Fluorescence; Humans; Male; Middle Aged; Predictive Value of Tests; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder; Urinary Bladder Neoplasms | 1994 |
Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic treatment.
Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Humans; Male; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins; Skin Neoplasms | 1995 |
Side effects and photosensitization of human tissues after aminolevulinic acid.
Topics: Adenocarcinoma; Administration, Oral; Aminolevulinic Acid; Female; Gastrointestinal Neoplasms; Humans; Liver; Liver Function Tests; Male; Nausea; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tissue Distribution; Vomiting | 1997 |
The variable response of plaque psoriasis after a single treatment with topical 5-aminolaevulinic acid photodynamic therapy.
Topics: Aminolevulinic Acid; Chronic Disease; Dose-Response Relationship, Radiation; Humans; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Psoriasis; Treatment Outcome | 1997 |
Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Basal Cell; Drug Interactions; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 1998 |
Photodynamic therapy for gastrointestinal tumors using three photosensitizers--ALA induced PPIX, Photofrin and MTHPC. A pilot study.
Topics: Adult; Aged; Aminolevulinic Acid; Dihematoporphyrin Ether; Duodenal Neoplasms; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Lasers; Male; Mesoporphyrins; Middle Aged; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Prodrugs; Protoporphyrins; Rectal Neoplasms | 1998 |
Treatment of oral leukoplakia by topical application of 5-aminolevulinic acid.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Argon; Female; Humans; Laser Therapy; Leukoplakia, Oral; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment Outcome | 1998 |
In vivo detection of basal cell carcinoma using imaging spectroscopy.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Basal Cell; Dermatologic Surgical Procedures; Female; Humans; Male; Microscopy, Fluorescence; Middle Aged; Mohs Surgery; Protoporphyrins; Skin; Skin Neoplasms | 1999 |
Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study.
Topics: Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Spectrometry, Fluorescence; Urinary Bladder Neoplasms | 1999 |
Kinetic fluorescence studies of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation in basal cell carcinomas.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Humans; Kinetics; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence | 1999 |
Photodynamic cystoscopy for detection of bladder tumors.
Topics: Adenocarcinoma, Papillary; Administration, Intravesical; Aminolevulinic Acid; Biopsy; Cystoscopy; Diagnosis, Differential; Fiber Optic Technology; Fluorescence; Follow-Up Studies; Humans; Neoplasm Recurrence, Local; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity; Urinary Bladder Neoplasms; Urothelium | 1999 |
5-Aminolevulinic acid photosensitization of dysplastic Barrett's esophagus: a pharmacokinetic study.
Topics: Aminolevulinic Acid; Barrett Esophagus; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 1999 |
Preliminary evaluation of two fluorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Male; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence | 2000 |
A vehicle for photodynamic therapy of skin cancer: influence of dimethylsulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy.
Topics: Aminolevulinic Acid; Animals; Dimethyl Sulfoxide; Humans; Mice; Mice, Hairless; Microscopy, Confocal; Myristates; Pharmaceutical Vehicles; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Absorption; Skin Neoplasms; Solubility | 2000 |
Heterogeneity of delta-aminolevulinic acid-induced protoporphyrin IX fluorescence in human glioma cells and leukemic lymphocytes.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Female; Glioblastoma; Humans; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocytes; Male; Microscopy, Confocal; Microscopy, Fluorescence; Middle Aged; Photochemistry; Phototherapy; Protoporphyrins; Tumor Cells, Cultured | 2000 |
Diagnostic efficacy of fluorescence cystoscopy for detection of urothelial neoplasms.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma in Situ; Cystoscopy; Female; Fluorescence; Humans; Light; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder Neoplasms | 2001 |
Detection of female lower genital tract dysplasia using orally administered 5-aminolevulinic acid induced protoporphyrin IX: a preliminary study.
Topics: Administration, Oral; Aminolevulinic Acid; Female; Humans; Papanicolaou Test; Photochemotherapy; Protoporphyrins; Uterine Cervical Dysplasia; Vaginal Smears | 2002 |
Clinical pharmacokinetics of 5-aminolevulinic acid in healthy volunteers and patients at high risk for recurrent bladder cancer.
Topics: Administration, Intravesical; Administration, Oral; Aminolevulinic Acid; Cross-Over Studies; Drug Administration Routes; Humans; Injections, Intravenous; Photosensitizing Agents; Protoporphyrins; Recurrence; Risk Factors; Urinary Bladder Neoplasms | 2002 |
Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques.
Topics: Administration, Oral; Aminolevulinic Acid; Apoptosis; CD3 Complex; Epidermis; Erythema; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; T-Lymphocytes; Treatment Outcome | 2002 |
Timing of 5-aminolaevulinic acid-induced photodynamic therapy for the treatment of patients with Barrett's oesophagus.
Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Biopsy; Endoscopy; Female; Gastric Mucosa; Humans; Male; Metabolic Clearance Rate; Middle Aged; Mucous Membrane; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reference Values; Tissue Distribution | 2002 |
A randomised, double-blind, placebo-controlled trial of photodynamic therapy using 5-aminolaevulinic acid for the treatment of cervical intraepithelial neoplasia.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Cervix Uteri; Colposcopy; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2003 |
Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer.
Topics: Administration, Intravesical; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Female; Humans; Male; Microscopy, Fluorescence; Middle Aged; Neoplasm Recurrence, Local; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Urinary Bladder; Urinary Bladder Neoplasms | 2003 |
The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical 5-aminolaevulinic acid photodynamic therapy.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Deferoxamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Erythema; Female; Fluorescence; Humans; Iontophoresis; Iron Chelating Agents; Male; Middle Aged; Photochemotherapy; Protoporphyrins; Skin Neoplasms | 2003 |
Fluorescence-guided resections of malignant gliomas--an overview.
Topics: Aminolevulinic Acid; Biopsy; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Division; Fluorescence; Germany; Glioma; Humans; Ki-67 Antigen; Microsurgery; Neoplasm, Residual; Neovascularization, Pathologic; Postoperative Complications; Prognosis; Protoporphyrins; Sensitivity and Specificity; Survival Rate | 2003 |
Comparison of high- vs low-dose 5-aminolevulinic acid for photodynamic therapy of Barrett's esophagus.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Lasers; Male; Middle Aged; Photochemotherapy; Protoporphyrins; Treatment Outcome | 2004 |
Laparoscopic fluorescence detection of ovarian carcinoma metastases using 5-aminolevulinic acid-induced protoporphyrin IX.
Topics: Adult; Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Infusions, Parenteral; Laparoscopy; Middle Aged; Ovarian Neoplasms; Peritoneal Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity | 2004 |
Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Humans; Middle Aged; Mouth Neoplasms; Patient Selection; Precancerous Conditions; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence | 2006 |
Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery.
Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Fluorescence; Humans; Lasers; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 2006 |
A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis.
Topics: Adult; Aminolevulinic Acid; Cell Differentiation; Cell Proliferation; Dose Fractionation, Radiation; Drug Administration Schedule; Epidermis; Female; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Severity of Illness Index; Skin; T-Lymphocyte Subsets; Treatment Outcome | 2006 |
Topical 5-aminolevulinic acid mediated photodynamic therapy of superficial basal cell carcinoma using two light fractions with a two-hour interval: long-term follow-up.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Pilot Projects; Protoporphyrins; Skin Neoplasms | 2006 |
In-vivo kinetics of inhaled 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in bronchial tissue.
Topics: Administration, Inhalation; Aged; Aged, 80 and over; Aminolevulinic Acid; Bronchi; Bronchial Neoplasms; Bronchoscopy; Female; Humans; Image Enhancement; Kinetics; Male; Metabolic Clearance Rate; Microscopy, Fluorescence; Middle Aged; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity | 2007 |
ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Fluorescence; Glioma; Humans; Neurosurgical Procedures; Photochemotherapy; Photosensitizing Agents; Prospective Studies; Protoporphyrins | 2007 |
Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Cell Line, Tumor; Humans; In Vitro Techniques; Iron Chelating Agents; Middle Aged; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Pyridones; Skin Neoplasms | 2008 |
Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial.
Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Edema; Erythema; Female; Fluorescence; Humans; Laser Therapy; Male; Pain; Patient Satisfaction; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Diseases; Treatment Outcome | 2008 |
Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded study.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Dose-Response Relationship, Drug; Facial Dermatoses; Female; Heliotherapy; Humans; Keratosis; Male; Middle Aged; Pain Measurement; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp Dermatoses; Single-Blind Method; Treatment Outcome | 2008 |
Surgical outcomes of fluorescence-guided laparoscopic partial nephrectomy using 5-aminolevulinic acid-induced protoporphyrin IX.
Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Renal Cell; Female; Fluorescence; Humans; Kidney Neoplasms; Laparoscopy; Male; Middle Aged; Monitoring, Intraoperative; Nephrectomy; Photosensitizing Agents; Predictive Value of Tests; Prospective Studies; Protoporphyrins | 2009 |
A time course investigation of the fluorescence induced by topical application of 5-aminolevulinic acid and methyl aminolevulinate on normal human skin.
Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Time Factors | 2009 |
Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema.
Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Erythema; Female; Humans; Light; Male; Needles; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Punctures; Silicon; Skin; Skin Absorption | 2010 |
Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Photobleaching; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Skin Neoplasms | 2010 |
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Male; Meningioma; Middle Aged; Photosensitizing Agents; Protoporphyrins; Young Adult | 2011 |
Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites.
Topics: Adult; Aged; Aminolevulinic Acid; Analysis of Variance; Extremities; Facial Dermatoses; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Scalp Dermatoses; Skin Neoplasms | 2011 |
PpIX fluorescence combined with auto-fluorescence is more accurate than PpIX fluorescence alone in fluorescence detection of non-melanoma skin cancer: an intra-patient direct comparison study.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Bowen's Disease; Carcinoma; Carcinoma, Basal Cell; False Negative Reactions; False Positive Reactions; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Single-Blind Method; Skin Neoplasms; Spectrometry, Fluorescence | 2012 |
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy, Needle; Brain Neoplasms; Female; Glioblastoma; Humans; Male; Microscopy, Fluorescence; Middle Aged; Monitoring, Intraoperative; Neuronavigation; Protoporphyrins | 2012 |
Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Oxygen; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Pressure; Protoporphyrins; Skin Neoplasms | 2013 |
The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device.
Topics: Aminolevulinic Acid; Biological Transport; Carcinoma, Basal Cell; Injections; Oxygen; Photosensitizing Agents; Pressure; Prodrugs; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Time Factors | 2012 |
Protoporphyrin IX fluorescence and photobleaching during interstitial photodynamic therapy of malignant gliomas for early treatment prognosis.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Biopsy; Brain; Brain Neoplasms; Female; Fluorescence; Follow-Up Studies; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Photobleaching; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Prospective Studies; Protoporphyrins; Spectrometry, Fluorescence; Treatment Outcome | 2013 |
Light protection of the skin after photodynamic therapy reduces inflammation: an unblinded randomized controlled study.
Topics: Aminolevulinic Acid; Drug Eruptions; Erythema; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Middle Aged; Photochemotherapy; Photosensitivity Disorders; Photosensitizing Agents; Protoporphyrins; Sunlight; Sunscreening Agents; Treatment Outcome | 2014 |
Biodistribution of protoporphyrin IX in female genital erosive lichen planus after topical application of hexaminolevulinate.
Topics: Administration, Topical; Aminolevulinic Acid; Dose-Response Relationship, Drug; Female; Genital Diseases, Female; Humans; Lichen Planus; Metabolic Clearance Rate; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tissue Distribution; Treatment Outcome | 2014 |
Topical corticosteroid reduces inflammation without compromising the efficacy of photodynamic therapy for actinic keratoses: a randomized clinical trial.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Anti-Inflammatory Agents; Clobetasol; Erythema; Facial Dermatoses; Female; Fluoroscopy; Glucocorticoids; Humans; Keratosis, Actinic; Male; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp Dermatoses; Treatment Outcome | 2014 |
Protoporphyrin IX formation after topical application of methyl aminolaevulinate and BF-200 aminolaevulinic acid declines with age.
Topics: Administration, Cutaneous; Adolescent; Adult; Age Factors; Aminolevulinic Acid; Drug Combinations; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Young Adult | 2015 |
Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Keratosis, Actinic; Optical Imaging; Photosensitizing Agents; Point-of-Care Systems; Protoporphyrins; Skin Neoplasms | 2015 |
Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.
Topics: Aminolevulinic Acid; Biomarkers; Dose-Response Relationship, Drug; Erythema; Female; Humans; Keratosis, Actinic; Male; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2015 |
Artificial White Light vs Daylight Photodynamic Therapy for Actinic Keratoses: A Randomized Clinical Trial.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Facial Dermatoses; Follow-Up Studies; Humans; Keratosis, Actinic; Light; Male; Middle Aged; Patient Satisfaction; Photochemotherapy; Photosensitizing Agents; Prospective Studies; Protoporphyrins; Scalp Dermatoses; Single-Blind Method; Time Factors; Treatment Outcome | 2016 |
Pulse photodynamic therapy reduces inflammation without compromising efficacy in the treatment of multiple mild actinic keratoses of the face and scalp: a randomized clinical trial.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Erythema; Facial Dermatoses; Female; Fluorescence; Humans; Keratosis, Actinic; Male; Ointments; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp Dermatoses; Treatment Outcome | 2016 |
Increased protoporphyrin IX accumulation does not improve the effect of photodynamic therapy for actinic keratosis: a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Curettage; Drug Eruptions; Erythema; Female; Fluorescence; Hand Dermatoses; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; Pain Measurement; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2017 |
Comparison of Physical Pretreatment Regimens to Enhance Protoporphyrin IX Uptake in Photodynamic Therapy: A Randomized Clinical Trial.
Topics: Adolescent; Adult; Aminolevulinic Acid; Curettage; Denmark; Dermabrasion; Female; Fluorescence; Humans; Laser Therapy; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Young Adult | 2017 |
A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma.
Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Craniotomy; Dose-Response Relationship, Drug; Europe; Female; Fluorescence; Glioma; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins | 2017 |
Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Curettage; Face; Female; Humans; Keratosis, Actinic; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Scalp | 2018 |
Enhancement of Photodynamic Therapy for Bowen's Disease Using Plum-Blossom Needling to Augment Drug Delivery.
Topics: Aged; Aminolevulinic Acid; Bowen's Disease; Drug Delivery Systems; Female; Fluorescence; Humans; Male; Middle Aged; Needles; Photochemotherapy; Photosensitizing Agents; Prospective Studies; Protoporphyrins; Skin Neoplasms | 2018 |
743 other study(ies) available for protoporphyrin ix and aminolevulinic acid
Article | Year |
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Comparing the efficacy of photodynamic and sonodynamic therapy in non-melanoma and melanoma skin cancer.
Topics: Aminolevulinic Acid; Animals; Heterografts; Humans; Melanoma; Mice, SCID; Photochemotherapy; Skin Neoplasms; Ultrasonic Therapy | 2016 |
Photodestruction of tumor cells by induction of endogenous accumulation of protoporphyrin IX: enhancement by 1,10-phenanthroline.
Topics: Aminolevulinic Acid; Animals; Cell Division; Humans; Phenanthrolines; Photochemotherapy; Protoporphyrins; Tumor Cells, Cultured | 1992 |
Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model.
Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Intestinal Mucosa; Microscopy, Fluorescence; Neoplasms, Experimental; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Time Factors | 1992 |
Enzymatic basis of thiol-stimulated secretion of porphyrins by Escherichia coli.
Topics: Aminolevulinic Acid; Coproporphyrins; Escherichia coli; Glycerol; Hemin; Porphyrins; Protoporphyrins; RNA, Transfer, Amino Acyl; RNA, Transfer, Glu | 1992 |
Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Blotting, Northern; Feedback; Hematologic Diseases; Heme; Humans; Kinetics; Protein Synthesis Inhibitors; Protoporphyrins; Reticulocytes; RNA, Messenger | 1991 |
Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence.
Topics: Aminolevulinic Acid; Animals; Ear; Fluorescence; Hair; Levulinic Acids; Mice; Photochemotherapy; Porphyrins; Protoporphyrins; Sebaceous Glands | 1990 |
Pharmacological activities of delta-aminolaevulinic acid, protoporphyrin IX and haemin in isolated preparations of rabbit gastric fundus and jejunum.
Topics: Aminolevulinic Acid; Animals; Female; Gastric Fundus; Heme; Hemin; In Vitro Techniques; Jejunum; Levulinic Acids; Male; Muscle Contraction; Muscle, Smooth; Porphyrins; Prazosin; Protoporphyrins; Rabbits | 1990 |
Pharmacological effects of haem biosynthetic intermediates in isolated intestinal preparations.
Topics: Aminolevulinic Acid; Animals; Colon; Coproporphyrins; Female; Glycine; Heme; Hemin; In Vitro Techniques; Intestinal Mucosa; Intestines; Jejunum; Male; Muscle Contraction; Porphobilinogen; Protoporphyrins; Rabbits; Succinates | 1987 |
Protoporphyrin accumulation by mitogen stimulated lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria variegata and erythropoietic protoporphyria: evidence for deficiency of protoporphyrinogen oxidase and ferrochelatase in both
Topics: Adult; Aminolevulinic Acid; Child; Edetic Acid; Ferrochelatase; Flavoproteins; Humans; Iron; Liver Diseases; Lymphocytes; Mitochondrial Proteins; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Porphyrias; Porphyrins; Protoporphyrinogen Oxidase; Protoporphyrins; Skin Diseases | 1985 |
Synthesis of [14C]coproporphyrin III by yeast cell-free extracts.
Topics: Aminolevulinic Acid; Cell-Free System; Chromatography; Coproporphyrins; Methods; Porphyrins; Protoporphyrins; Saccharomyces cerevisiae | 1982 |
Blood protoporphyrin IX as a biological indicator of increased absorption of lead.
Topics: Adult; Aminolevulinic Acid; Humans; Lead; Lead Poisoning; Male; Mexico; Occupational Diseases; Porphyrins; Protoporphyrins | 1981 |
Mechanism of thiamine-induced respiratory deficiency in Saccharomyces carlsbergensis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrins; Cytochromes; Heme; Protoporphyrins; Pyridoxine; Saccharomyces; Thiamine | 1981 |
Mitogenic and co-mitogenic properties of hemin.
Topics: Adult; Aminolevulinic Acid; Animals; Biliverdine; Cattle; Concanavalin A; Heme; Hemin; Horses; Humans; Immunity, Cellular; Lymphocyte Activation; Middle Aged; Mitogens; Protoporphyrins; Thymidine | 1981 |
Efficacy of intravenous delta-aminolaevulinic acid photodynamic therapy on rabbit papillomas.
Topics: Aminolevulinic Acid; Animals; Papilloma; Photochemotherapy; Protoporphyrins; Rabbits; Skin | 1995 |
The effect of aminolaevulinic acid-induced, protoporphyrin IX-mediated photodynamic therapy on the cremaster muscle microcirculation in vivo.
Topics: Aminolevulinic Acid; Animals; Arterioles; Male; Microcirculation; Muscle, Skeletal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Venules | 1995 |
Wavelength dependency of photodynamic effects after sensitization with 5-aminolevulinic acid in vitro and in vivo.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Survival; Cricetinae; Humans; Keratinocytes; Light; Mesocricetus; Microscopy, Confocal; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 1995 |
Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Colonic Neoplasms; Dimethyl Sulfoxide; Edetic Acid; Female; Kinetics; Mice; Mice, Inbred BALB C; Protoporphyrins; Skin; Spectrometry, Fluorescence; Time Factors | 1995 |
Subcellular localization of and photosensitization by protoporphyrin IXhuman keratinocytes and fibroblasts cultivated with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Cells, Cultured; Fibrinogen; Fibroblasts; Humans; Keratinocytes; Photochemistry; Photosensitizing Agents; Porphyrins; Protoporphyrins; Spectrometry, Fluorescence; Subcellular Fractions | 1995 |
Enhancement of photodynamic therapy with 5-aminolaevulinic acid-induced porphyrin photosensitisation in normal rat colon by threshold and light fractionation studies.
Topics: Aminolevulinic Acid; Animals; Colon; Colonic Neoplasms; Female; Light; Maximum Allowable Concentration; Photochemotherapy; Protoporphyrins; Radiation-Sensitizing Agents; Rats; Rats, Wistar | 1995 |
Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Squamous Cell; Fluorescence; Humans; Laser Therapy; Mouth Neoplasms; Necrosis; Palliative Care; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 1993 |
Treatment with 5-aminolevulinic acid and photoactivating light causes destruction of preimplantation mouse embryos.
Topics: Aminolevulinic Acid; Animals; Blastocyst; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Light; Mice; Morula; Photochemistry; Pregnancy; Protoporphyrins; Spectrometry, Fluorescence | 1995 |
Combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Cycle; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Flow Cytometry; G2 Phase; Humans; Kinetics; Light; Protoporphyrins; Radiation-Sensitizing Agents; Radiation, Ionizing; S Phase; Time Factors; Tumor Cells, Cultured; X-Rays | 1995 |
The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA).
Topics: Aminolevulinic Acid; Cells, Cultured; Heme; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Photochemotherapy; Protoporphyrins; Receptors, Transferrin; Reference Values; Sezary Syndrome; Skin Neoplasms | 1995 |
[Superficial bladder tumors. Pathological and clinical review and presentation of a new diagnostic method: fluorescence photodetection of transitional epithelial carcinomas based on protoporphyrin IX induction with delta-aminolevulinic acid (5-ALA)].
Topics: Aged; Aged, 80 and over; Algorithms; Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopy; Female; Humans; Male; Middle Aged; Protoporphyrins; Spectrometry, Fluorescence; Urinary Bladder Neoplasms | 1995 |
Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands.
Topics: Aminolevulinic Acid; Animals; Benzodiazepines; Benzodiazepinones; Cell Division; Cell Survival; Clonazepam; Flumazenil; Isoquinolines; Ligands; Mitochondria; Oxygen; Pancreatic Neoplasms; Photochemotherapy; Protoporphyrins; Radiation-Protective Agents; Radiation-Sensitizing Agents; Rats; Receptors, GABA-A; Singlet Oxygen; Tumor Cells, Cultured | 1995 |
Biodistribution and phototoxicity of 5-aminolevulinic acid-induced PpIX in an orthotopic rat bladder tumor model.
Topics: Aminolevulinic Acid; Animals; Female; Neoplasm Transplantation; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred F344; Tissue Distribution; Urinary Bladder Neoplasms | 1995 |
Studies of porphyrin-containing specimens using an optical spectrometer connected to a confocal scanning laser microscope.
Topics: Aminolevulinic Acid; Animals; Hematoporphyrin Derivative; Liver; Microscopy, Confocal; Protoporphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence | 1994 |
[Photodynamic diagnosis of urothelial neoplasms after intravesicular instillation of 5-aminolevulinic acid].
Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Carcinoma, Transitional Cell; Cystoscopes; Female; Fluorescence; Humans; Image Processing, Computer-Assisted; Laser Therapy; Lasers; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Precancerous Conditions; Protoporphyrins; Urinary Bladder; Urinary Bladder Neoplasms; Video Recording | 1994 |
In vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid-induced porphyrin: increased damage after multiple irradiations.
Topics: Aminolevulinic Acid; Animals; Drug Administration Schedule; Female; Fluorescence; Kinetics; Mammary Neoplasms, Experimental; Necrosis; Neoplasm Transplantation; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred Strains; Time Factors | 1994 |
Intravesical instillation of 5-aminolevulinic acid: the fluorescent metabolite is limited to urothelial cells.
Topics: Administration, Intravesical; Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Papillary; Cell Line, Transformed; Cells, Cultured; Cystoscopy; Epithelium; Fibroblasts; Humans; Hyperplasia; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins; Urinary Bladder; Urinary Bladder Neoplasms | 1994 |
Photodynamic destruction of endometrial tissue with topical 5-aminolevulinic acid in rats and rabbits.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Endometrium; Female; Fluorescence; Microscopy, Electron, Scanning; Photochemotherapy; Protoporphyrins; Rabbits; Rats; Rats, Sprague-Dawley; Uterus | 1994 |
Kinetics of endogenous protoporphyrin IX induction by aminolevulinic acid: preliminary studies in the bladder.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Female; Injections, Intravenous; Kinetics; Photochemotherapy; Protoporphyrins; Rats; Rats, Wistar; Urinary Bladder | 1994 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; Cells, Cultured; Deferoxamine; Ferrochelatase; Fibroblasts; Humans; Melanoma; Mice; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Protoporphyrins; Rats; Skin Neoplasms; Spectrometry, Fluorescence; Tumor Cells, Cultured; Up-Regulation; Urinary Bladder Neoplasms; Verapamil | 1994 |
Photodynamic therapy of normal rat arteries after photosensitisation using disulphonated aluminium phthalocyanine and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Arteries; Endothelium, Vascular; Female; Femoral Artery; Indoles; Muscle, Smooth, Vascular; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Regeneration; Spectrometry, Fluorescence; Vascular Patency | 1994 |
Photodynamic therapy using 5-aminolaevulinic acid for experimental pancreatic cancer--prolonged animal survival.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cricetinae; Disease Models, Animal; Female; Heme; Injections, Intravenous; Lasers; Mesocricetus; Microscopy, Fluorescence; Neoplasm Transplantation; Pancreatic Neoplasms; Photochemotherapy; Protoporphyrins; Sensitivity and Specificity; Time Factors | 1994 |
Penetration potency of topical applied delta-aminolevulinic acid for photodynamic therapy of basal cell carcinoma.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins; Skin Neoplasms | 1994 |
In vivo photoproduct formation during PDT with ALA-induced endogenous porphyrins.
Topics: Aminolevulinic Acid; Animals; Female; Humans; Kinetics; Light; Mice; Mice, Nude; Neoplasm Transplantation; Photochemotherapy; Porphyrins; Protoporphyrins; Skin; Spectrometry, Fluorescence; Transplantation, Heterologous; Transplantation, Heterotopic; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1993 |
The production of porphyrins from delta-aminolaevulinic acid by Haemophilus parainfluenzae.
Topics: Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture Media; Haemophilus; Hydrogen-Ion Concentration; Porphyrins; Protoporphyrins | 1993 |
delta-Aminolevulinic acid induced fluorescence in tumour-bearing mice.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Lewis Lung; Female; Fibrosarcoma; Fluorescence; Hematoporphyrins; Leukemia, Lymphoid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms, Experimental; Photosensitizing Agents; Protoporphyrins; Time Factors | 1995 |
HepG2 human hepatocarcinoma cells: an experimental model for photosensitization by endogenous porphyrins.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Flow Cytometry; Hematoporphyrins; Humans; Lasers; Models, Biological; Photosensitizing Agents; Phototherapy; Protoporphyrins; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured | 1995 |
Cellular fluorescence of the endogenous photosensitizer protoporphyrin IX following exposure to 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Cell Line; Flow Cytometry; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Urinary Bladder; Urinary Bladder Neoplasms | 1995 |
Subcellular damage kinetics within co-cultivated WI38 and VA13-transformed WI38 human fibroblasts following 5-aminolevulinic acid-induced protoporphyrin IX formation.
Topics: Aminolevulinic Acid; Cell Line, Transformed; Fibroblasts; Humans; Lung; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Subcellular Fractions | 1995 |
Fluorescence and photosensitization of experimental endometriosis in the rat after systemic 5-aminolevulinic acid administration: a potential new approach to the diagnosis and treatment of endometriosis.
Topics: Aminolevulinic Acid; Animals; Endometriosis; Female; Fluorescence; Kinetics; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1996 |
Flow cytometric technique for quantitating cytotoxic response to photodynamic therapy.
Topics: Aminolevulinic Acid; Carcinoma, Small Cell; Cell Survival; Flow Cytometry; Humans; Lung Neoplasms; Photochemotherapy; Protoporphyrins; Tumor Cells, Cultured | 1996 |
Fluorescence cystoscopy following intravesical instillation of 5-aminolevulinic acid: a new procedure with high sensitivity for detection of hardly visible urothelial neoplasias.
Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cystoscopy; Epithelium; Fluorescence; Humans; Microscopy, Fluorescence; Middle Aged; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Urinary Bladder Neoplasms | 1995 |
Photosensitization of the endometrium with topical 5-aminolevulinic acid.
Topics: Administration, Topical; Aminolevulinic Acid; Biotransformation; Endometrium; Female; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 1995 |
Kinetics and localisation of PpIX fluorescence after topical and systemic ALA application, observed in skin and skin tumours of UVB-treated mice.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Female; Injections, Intraperitoneal; Keratitis; Mice; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Ultraviolet Rays | 1996 |
A comparative study of tissue distribution and photodynamic therapy selectivity of chlorin e6, Photofrin II and ALA-induced protoporphyrin IX in a colon carcinoma model.
Topics: Aminolevulinic Acid; Animals; Chlorophyllides; Colonic Neoplasms; Dihematoporphyrin Ether; Female; Fluorescence; Mice; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Tissue Distribution | 1996 |
Biodistribution of protoporphyrin IX in rat urinary bladder after intravesical instillation of 5-aminolevulinic acid.
Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Female; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Tissue Distribution; Urinary Bladder | 1996 |
Feasibility of photodynamic therapy using endogenous photosensitization for colon cancer.
Topics: Adenocarcinoma; Administration, Oral; Aminolevulinic Acid; Biopsy; Colectomy; Colon, Sigmoid; Follow-Up Studies; Gardner Syndrome; Humans; Male; Middle Aged; Necrosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sigmoid Neoplasms; Time Factors | 1996 |
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Apoptosis; Cells, Cultured; Colonic Neoplasms; Cricetinae; Cricetulus; Fibroblasts; Humans; Light; Necrosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 1996 |
Photodynamic therapy on the normal rabbit larynx with phthalocyanine and 5-aminolaevulinic acid induced protoporphyrin IX photosensitisation.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Indoles; Larynx; Male; Microscopy, Fluorescence; Necrosis; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rabbits | 1996 |
Formation of water-soluble porphyrins and protoporphyrin IX in 5-aminolevulinic-acid-incubated carcinoma cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Ehrlich Tumor; Glucose; Mice; Photolysis; Porphyrins; Protoporphyrins; Solubility; Temperature; Time Factors; Tumor Cells, Cultured; Water | 1996 |
Accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in normal and neoplastic human endometrial epithelial cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cells, Cultured; Endometrial Neoplasms; Endometrium; Epithelial Cells; Epithelium; Female; Flow Cytometry; Fluorescence; Humans; Protoporphyrins; Tumor Cells, Cultured | 1996 |
The accumulation of protoporphyrin IX in plaque psoriasis after topical application of 5-aminolevulinic acid indicates a potential for superficial photodynamic therapy.
Topics: Administration, Topical; Aminolevulinic Acid; Dose-Response Relationship, Drug; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Pyrimidinones; Reference Values | 1996 |
Eradication of high-grade dysplasia in columnar-lined (Barrett's) oesophagus by photodynamic therapy with endogenously generated protoporphyrin IX.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Humans; Male; Middle Aged; Photochemotherapy; Protoporphyrins | 1996 |
The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Cricetinae; Cricetulus; Dicarbethoxydihydrocollidine; Edetic Acid; Fibroblasts; Humans; Iron Chelating Agents; Microscopy, Fluorescence; Organothiophosphates; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 1996 |
Effects of the inhibitors of energy metabolism, lonidamine and levamisole, on 5-aminolevulinic-acid-induced photochemotherapy.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cricetinae; Cricetulus; Energy Metabolism; Indazoles; Levamisole; NAD; Nucleotides; Photochemotherapy; Protoporphyrins | 1996 |
In vitro studies on the potential use of 5-aminolaevulinic acid-mediated photodynamic therapy for gynaecological tumours.
Topics: Aminolevulinic Acid; Drug Resistance; Female; Genital Neoplasms, Female; HeLa Cells; Humans; Photochemotherapy; Protoporphyrins | 1996 |
Dosimetry model for photodynamic therapy with topically administered photosensitizers.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biological Transport, Active; Dogs; Models, Biological; Optics and Photonics; Oxygen; Photochemistry; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin; Skin Absorption; Skin Neoplasms | 1996 |
Detection of early stages of carcinogenesis in adenomas of murine lung by 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Adenoma; Aminolevulinic Acid; Animals; Bronchoscopy; Fluorescence; Fluorometry; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Photosensitizing Agents; Protoporphyrins | 1996 |
Aminolevulinic acid for photodynamic therapy of bladder carcinoma cells.
Topics: Aminolevulinic Acid; Cell Survival; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1996 |
Photodynamic therapy using intravenous delta-aminolaevulinic acid-induced protoporphyrin IX sensitisation in experimental hepatic tumours in rats.
Topics: Aminolevulinic Acid; Animals; Cell Division; Drug Interactions; Liver; Liver Neoplasms, Experimental; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred WF; Spectrometry, Fluorescence | 1996 |
Selective photosensitizer localization in the human endometrium after intrauterine application of 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Endometrium; Female; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 1996 |
Iontophoretic delivery of ALA provides a quantitative model for ALA pharmacokinetics and PpIX phototoxicity in human skin.
Topics: Adult; Aminolevulinic Acid; Dose-Response Relationship, Radiation; Erythema; Female; Fluorescent Dyes; Humans; Iontophoresis; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Time Factors | 1997 |
The effect of brief illumination on intracellular free calcium concentration in cells with 5-aminolevulinic acid-induced protoporphyrin IX synthesis.
Topics: Adenocarcinoma; Aminolevulinic Acid; Calcium; Colonic Neoplasms; Cytosol; DNA; Egtazic Acid; Fluorescent Dyes; Fura-2; Humans; Light; Protoporphyrins; Tumor Cells, Cultured | 1996 |
Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Cells, Cultured; Humans; Photochemistry; Photosensitizing Agents; Protoporphyrins | 1997 |
Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the detection of neoplastic lesions in the oral cavity.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Endoscopy; Humans; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Pharyngeal Neoplasms; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 1996 |
In-vitro investigation of ALA-induced protoporphyrin IX.
Topics: Aminolevulinic Acid; Dose-Response Relationship, Drug; Fibroblasts; Humans; Hydrogen-Ion Concentration; Kinetics; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence | 1996 |
Inhalation of 5-aminolevulinic acid: a new technique for fluorescence detection of early stage lung cancer.
Topics: Administration, Inhalation; Aminolevulinic Acid; Animals; Dogs; Lung Neoplasms; Protoporphyrins; Spectrometry, Fluorescence | 1996 |
Plasma levels of protoporphyrin IX in humans after oral administration of 5-aminolevulinic acid.
Topics: Administration, Oral; Aged; Aminolevulinic Acid; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 1997 |
The pH dependency of protoporphyrin IX formation in cells incubated with 5-aminolevulinic acid.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Survival; Colonic Neoplasms; Cricetinae; Fibroblasts; Humans; Hydrogen-Ion Concentration; Lung; Proteins; Protoporphyrins; Tumor Cells, Cultured | 1997 |
Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Drug Interactions; Humans; Liver Neoplasms, Experimental; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred WF; Skin; Skin Neoplasms; Spectrometry, Fluorescence | 1997 |
Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopes; Cystoscopy; Evaluation Studies as Topic; Female; Fluorescence; Humans; Krypton; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder; Urinary Bladder Neoplasms; Urine; Xenon | 1997 |
Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Cricetinae; Cricetulus; Drug Screening Assays, Antitumor; Esters; Female; Fibroblasts; Humans; Neoplasm Proteins; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1997 |
5-Aminolevulinic acid (ALA)-induced protoporphyrin IX fluorescence and photodynamic effects in the rat bladder: an in vivo study comparing oral and intravesical ALA administration.
Topics: Administration, Intravesical; Administration, Oral; Aminolevulinic Acid; Animals; Female; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Rats; Rats, Wistar; Skin; Urinary Bladder | 1997 |
Laser-induced fluorescence studies of normal and malignant tumour tissue of rat following intravenous injection of delta-amino levulinic acid.
Topics: Aminolevulinic Acid; Animals; Injections, Intravenous; Lasers; Muscles; Neoplasms, Experimental; Protoporphyrins; Rats; Rats, Inbred WF; Spectrometry, Fluorescence; Tissue Distribution; Tumor Cells, Cultured | 1997 |
Clinical evaluation of a method for detecting superficial surgical transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following the topical application of 5-aminolevulinic acid: preliminary results.
Topics: Administration, Cutaneous; Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Evaluation Studies as Topic; Female; Fluorescence; Humans; Male; Middle Aged; Photofluorography; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms | 1997 |
[The clinical value of fluorescence cystoscopy in the detection of superficial transitional epithelial cell carcinoma of the bladder].
Topics: Administration, Intravesical; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Transitional Cell; Cystoscopy; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Photosensitizing Agents; Prodrugs; Prognosis; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity; Urinary Bladder Neoplasms | 1997 |
Comparison of delta-aminolaevulinic acid and its methyl ester as an inducer of porphyrin synthesis in cultured cells.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Extracellular Space; Heme; Liver; Photosensitizing Agents; Protoporphyrins; Rats; Stimulation, Chemical | 1997 |
The efficacy of an iron chelator (CP94) in increasing cellular protoporphyrin IX following intravesical 5-aminolaevulinic acid administration: an in vivo study.
Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Female; Iron Chelating Agents; Kinetics; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Pyridones; Rats; Rats, Wistar; Spectrometry, Fluorescence; Urinary Bladder | 1997 |
In vivo fluorescence kinetics of porphyrins following intravesical instillation of 5-aminolaevulinic acid in normal and tumour-bearing rat bladders.
Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Female; Kinetics; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence; Urinary Bladder; Urinary Bladder Neoplasms | 1997 |
On-line fluorescence of human tissues after oral administration of 5-aminolevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Drug Administration Schedule; Gastrointestinal Neoplasms; Humans; Mouth Mucosa; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Regional Blood Flow; Skin; Spectrometry, Fluorescence; Surface Properties; Tissue Distribution | 1997 |
The importance of fluorescence distribution and kinetics of ALA-induced PpIX in the bladder in photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Female; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Urinary Bladder | 1997 |
N-conjugates of 2,5-disubstituted pyrrole and glutathione. Evaluation of their potency as antioxidants against photosensitization of NCTC 2544 keratinocytes by excess endogenous protoporphyrin IX.
Topics: Aminolevulinic Acid; Antioxidants; Cell Line; Glutathione; Humans; Keratinocytes; Light; Molecular Structure; Photosensitizing Agents; Protoporphyrins; Pyrroles | 1997 |
Photobleaching during and re-appearance after photodynamic therapy of topical ALA-induced fluorescence in UVB-treated mouse skin.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Mice; Mice, Inbred Strains; Photochemistry; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Radiation Injuries, Experimental; Skin; Ultraviolet Rays | 1997 |
Interstitial photodynamic therapy in the canine prostate with disulfonated aluminum phthalocyanine and 5-aminolevulinic acid-induced protoporphyrin IX.
Topics: Aminolevulinic Acid; Animals; Atrophy; Collagen; Dogs; Indoles; Lasers; Light; Male; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Prostate; Prostatic Neoplasms; Protoporphyrins | 1997 |
Correlation between plasma 5-aminolevulinic acid concentrations and indicators of oxidative stress in lead-exposed workers.
Topics: Adolescent; Adult; Aminolevulinic Acid; Humans; Lead; Luminescent Measurements; Male; Methemoglobinemia; Middle Aged; Occupational Exposure; Oxidative Stress; Protoporphyrins; Superoxide Dismutase | 1997 |
In vivo fluorescence detection of ovarian cancer in the NuTu-19 epithelial ovarian cancer animal model using 5-aminolevulinic acid (ALA).
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Epithelium; Feasibility Studies; Female; Fluorescence; Image Processing, Computer-Assisted; Mice; Mice, Nude; Microscopy, Fluorescence; Ovarian Neoplasms; Peritoneal Neoplasms; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344 | 1997 |
Protoporphyrin-IX distribution and photodynamic effect in rat oesophagus after aminolaevulinic acid administration.
Topics: Aminolevulinic Acid; Animals; Esophagus; Male; Microscopy, Fluorescence; Mucous Membrane; Muscle, Smooth; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Time Factors | 1997 |
Potential efficacy of a delta 5-aminolevulinic acid bioadhesive gel formulation for the photodynamic treatment of lesions of the gastrointestinal tract in mice.
Topics: Aminolevulinic Acid; Animals; Barrett Esophagus; Biocompatible Materials; Disease Models, Animal; Fiber Optic Technology; Gallbladder; Gastric Mucosa; Gels; In Vitro Techniques; Liver; Male; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Stomach Neoplasms; Tissue Adhesives | 1997 |
Enhancement of photodynamic therapy in gastric cancer cells by removal of iron.
Topics: Aminolevulinic Acid; Cell Survival; Deferoxamine; Ferrochelatase; Humans; Iron; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Siderophores; Stomach Neoplasms; Tumor Cells, Cultured | 1997 |
H-dependent formation of 5-aminolaevulinic acid-induced protoporphyrin IX in fibrosarcoma cells.
Topics: Aminolevulinic Acid; Animals; Cell Survival; Fibrosarcoma; Flow Cytometry; Hydrogen-Ion Concentration; Kinetics; Light; Mice; Photochemotherapy; Protoporphyrins; Tumor Cells, Cultured | 1997 |
Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX.
Topics: Aminolevulinic Acid; Cell Division; Cell Survival; Cells, Cultured; Culture Media; Endothelium, Vascular; Humans; Muscle, Smooth, Vascular; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Ultraviolet Rays | 1997 |
Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells.
Topics: Aminolevulinic Acid; Carcinoma; Colonic Neoplasms; Hematoporphyrins; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 1997 |
Effects of fractionated 5-aminolevulinic acid administration on tissue levels of protoporphyrin in vivo.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Mice; Photosensitizing Agents; Prodrugs; Protoporphyrins | 1997 |
Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits.
Topics: Administration, Oral; Aminolevulinic Acid; Analysis of Variance; Animals; Chelating Agents; Chronic Disease; Dietary Supplements; Edetic Acid; Female; Lead; Lead Poisoning; Magnesium; Protoporphyrins; Rabbits | 1997 |
Pharmacokinetics of 5-aminolevulinic acid-induced protoporphyrin IX in skin and blood.
Topics: Aged; Aminolevulinic Acid; Fluorescence; Humans; Middle Aged; Protoporphyrins; Skin | 1997 |
Hormonal modulation of the accumulation of 5-aminolevulinic acid-induced protoporphyrin and phototoxicity in prostate cancer cells.
Topics: Aminolevulinic Acid; Animals; Blood; Cattle; Cell Division; Cell Survival; Culture Media; Dihydrotestosterone; Estradiol; Humans; Kinetics; Male; Photochemotherapy; Prostatic Neoplasms; Protoporphyrins; Tumor Cells, Cultured | 1997 |
Selectivity of protoporphyrin IX fluorescence for condylomata after topical application of 5-aminolaevulinic acid: implications for photodynamic treatment.
Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Condylomata Acuminata; Humans; Male; Microscopy, Fluorescence; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence | 1997 |
Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Communication; Cell Count; Cell Cycle; Cell Line; Colonic Neoplasms; Cricetinae; Cricetulus; Fibroblasts; Humans; Protoporphyrins; Tumor Cells, Cultured | 1998 |
Porphyrin sensitization and intracellular calcium changes in the prokaryote Propionibacterium acnes.
Topics: Aminolevulinic Acid; Calcium; Fura-2; Light; Photosensitizing Agents; Porphyrins; Propionibacterium acnes; Protoporphyrins | 1997 |
Delta-aminolevulinic acid-induced fluorescence in normal human lymphocytes.
Topics: Aminolevulinic Acid; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Fluorescence; Humans; Mitogens; Phytohemagglutinins; Pokeweed Mitogens; Prodrugs; Protoporphyrins; Spectrometry, Fluorescence | 1997 |
Effect of continuous and multiple doses of 5-aminolevulinic acid on protoporphyrin IX concentrations in the rat uterus.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Endometrium; Female; Hydrogen-Ion Concentration; Protoporphyrins; Rats; Rats, Sprague-Dawley; Solutions; Temperature; Time Factors | 1997 |
A hydroxypyridinone (CP94) enhances protoporphyrin IX formation in 5-aminolaevulinic acid treated cells.
Topics: Aminolevulinic Acid; Cell Line; Darkness; Humans; Iron Chelating Agents; Microscopy, Fluorescence; Molecular Structure; Prodrugs; Protoporphyrins; Pyridones; Spectrometry, Fluorescence | 1997 |
Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Radiation; Fluorescence; Light; Mice; Mice, Hairless; Photochemotherapy; Protoporphyrins; Skin | 1998 |
Derivatives of 5-aminolevulinic acid for photodynamic therapy: enzymatic conversion into protoporphyrin.
Topics: Aminolevulinic Acid; Humans; Hydrolysis; Photochemotherapy; Prodrugs; Protoporphyrins; Tumor Cells, Cultured | 1998 |
[Eradication of high-grade dysplasia in Barrett esophagus by photodynamic therapy with endogenously generated protoporphyrin IX].
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagus; Female; Humans; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins | 1998 |
[Photodynamic diagnosis of gastrointestinal precancerous lesions after sensitization with 5-aminolevulinic acid. A pilot study].
Topics: Adenoma; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Colitis, Ulcerative; Colorectal Neoplasms; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Photosensitizing Agents; Pilot Projects; Polyps; Precancerous Conditions; Protoporphyrins; Stomach Neoplasms | 1998 |
Characterization of endogenous protoporphyrin IX induced by delta-aminolevulinic acid in resting and activated peripheral blood lymphocytes by four-color flow cytometry.
Topics: Aminolevulinic Acid; Flow Cytometry; Humans; Immunophenotyping; Lymphocyte Activation; Lymphocytes; Protoporphyrins; Receptors, Transferrin | 1998 |
Biodistribution of Photofrin II and 5-aminolevulinic acid-induced protoporphyrin IX in normal rat bladder and bladder tumor models: implications for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Dihematoporphyrin Ether; Disease Models, Animal; Female; Photochemotherapy; Protoporphyrins; Rats; Tissue Distribution; Tumor Cells, Cultured; Urinary Bladder; Urinary Bladder Neoplasms | 1998 |
The influence of hypoxia and pH on aminolaevulinic acid-induced photodynamic therapy in bladder cancer cells in vitro.
Topics: Acidosis; Aminolevulinic Acid; Cell Hypoxia; Cell Survival; Humans; Hydrogen-Ion Concentration; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1998 |
Hemodynamic effects of 5-aminolevulinic acid in humans.
Topics: Aminolevulinic Acid; Blood Pressure; Capillaries; Cardiac Output; Heart Failure; Hemodynamics; Humans; Photochemotherapy; Protoporphyrins; Pulmonary Artery; Pulmonary Wedge Pressure; Pulse; Vascular Resistance | 1998 |
Cell cycle phase influences tumour cell sensitivity to aminolaevulinic acid-induced photodynamic therapy in vitro.
Topics: Aminolevulinic Acid; Cell Cycle; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1998 |
Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes.
Topics: Aminolevulinic Acid; Animals; Calcium; Cell Differentiation; Heme; Keratinocytes; Mice; Photochemotherapy; Porphobilinogen Synthase; Protoporphyrins; Rats; RNA, Messenger | 1998 |
Delta-aminolevulinic acid-mediated photosensitization of prostate cell lines: implication for photodynamic therapy of prostate cancer.
Topics: Aminolevulinic Acid; Cell Survival; Humans; Male; Microscopy, Electron; Mitochondria; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Tumor Cells, Cultured | 1998 |
Biochemical basis of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus.
Topics: Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagus; Female; Ferrochelatase; Humans; Hydroxymethylbilane Synthase; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Prodrugs; Protoporphyrins | 1998 |
5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration.
Topics: Administration, Oral; Alanine Transaminase; Aminolevulinic Acid; Animals; Aspartate Aminotransferases; Creatinine; Injections, Intravenous; Kidney Function Tests; Male; Microscopy, Confocal; Photosensitizing Agents; Porphobilinogen; Protoporphyrins; Rats; Rats, Inbred Strains; Tissue Distribution; Urea | 1998 |
Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; Protoporphyrins; Tumor Cells, Cultured; Ultrasonics | 1998 |
Intra-arterial photodynamic therapy using 5-ALA in a swine model.
Topics: Aminolevulinic Acid; Angioplasty, Balloon; Animals; Carotid Arteries; Catheterization; Iliac Artery; Muscle, Smooth, Vascular; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Recurrence; Swine; Time Factors | 1998 |
Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Microsurgery; Protoporphyrins; Sensitivity and Specificity | 1998 |
Antigen specific and nonspecific modulation of the immune response by aminolevulinic acid based photodynamic therapy.
Topics: Aminolevulinic Acid; Dendritic Cells; HLA-D Antigens; Humans; Lymphocytes; Macrophages; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 1998 |
Kinetics of photobleaching of protoporphyrin IX in the skin of nude mice exposed to different fluence rates of red light.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Kinetics; Light; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemistry; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence | 1998 |
Expression kinetics of the (proto) oncogenes c-myc and bcl-2 following photodynamic treatment of normal and transformed human fibroblasts with 5-aminolaevulinic acid-stimulated endogenous protoporphyrin IX.
Topics: Aminolevulinic Acid; Cell Line; Cell Line, Transformed; Fibroblasts; Gene Expression; Humans; Kinetics; Photosensitizing Agents; Proto-Oncogene Mas; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Protoporphyrins | 1998 |
In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Glioma; Humans; Male; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Tumor Cells, Cultured | 1998 |
Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis, or adenomatous polyps after 5-aminolevulinic acid-induced protoporphyrin IX sensitization.
Topics: Adenomatous Polyps; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Biopsy; Colitis, Ulcerative; Diagnosis, Differential; Endoscopy, Gastrointestinal; Female; Follow-Up Studies; Humans; Male; Metaplasia; Microscopy, Fluorescence; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Rectal Neoplasms | 1999 |
Selective destruction of leukaemic cells by photo-activation of 5-aminolaevulinic acid-induced protoporphyrin-IX.
Topics: Aminolevulinic Acid; Bone Marrow Cells; Cell Division; Cell Survival; Hematopoietic Stem Cells; HL-60 Cells; Humans; Jurkat Cells; Leukemia; Photosensitizing Agents; Protoporphyrins; Time Factors; Tumor Cells, Cultured | 1998 |
Protoporphyrin IX fluorescence photobleaching during ALA-mediated photodynamic therapy of UVB-induced tumors in hairless mouse skin.
Topics: Aminolevulinic Acid; Animals; Female; Fluorescence; Male; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Photobiology; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Ultraviolet Rays | 1999 |
Timing of illumination is essential for effective and safe photodynamic therapy: a study in the normal rat oesophagus.
Topics: Aminolevulinic Acid; Animals; Edema; Esophagus; Light; Male; Mucous Membrane; Muscle, Smooth; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence; Time Factors | 1999 |
Fluorescence diagnostics and kinetic studies in the head and neck region utilizing low-dose delta-aminolevulinic acid sensitization.
Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Dose-Response Relationship, Drug; Endoscopy; Female; Head and Neck Neoplasms; Humans; Lasers; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 1999 |
Protoporphyrin IX-sensitized photoinactivation of 5-aminolevulinate-treated leukemia cells: effects of exogenous iron.
Topics: Aminolevulinic Acid; Animals; Ferric Compounds; Hydroxyquinolines; Leukemia L1210; Mice; Photochemotherapy; Porphyrins; Protoporphyrins; Tumor Cells, Cultured | 1999 |
Effect of 2,2'-dipyridyl on accumulation of protoporphyrin IX and its derivatives in yeast mitochondria and plasma membranes.
Topics: 2,2'-Dipyridyl; Aminolevulinic Acid; Cell Membrane; Iron Chelating Agents; Mitochondria; Photosensitizing Agents; Protoporphyrins; Saccharomyces cerevisiae; Spectrometry, Fluorescence | 1999 |
Hypoxia significantly reduces aminolaevulinic acid-induced protoporphyrin IX synthesis in EMT6 cells.
Topics: Aminolevulinic Acid; Cell Count; Cell Division; Cell Hypoxia; Protoporphyrins; Tumor Cells, Cultured | 1999 |
The iron regulatory protein can determine the effectiveness of 5-aminolevulinic acid in inducing protoporphyrin IX in human primary skin fibroblasts.
Topics: Aminolevulinic Acid; Cells, Cultured; Deferoxamine; Humans; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Photochemotherapy; Protoporphyrins; RNA; RNA-Binding Proteins; Skin; Ultraviolet Rays | 1999 |
Uptake of topically applied 5-aminolevulinic acid and production of protoporphyrin IX in normal mouse skin: dependence on skin temperature.
Topics: Aminolevulinic Acid; Animals; Female; Mice; Mice, Hairless; Mice, Inbred BALB C; Photobiology; Photochemotherapy; Protoporphyrins; Skin; Skin Temperature | 1999 |
Kidney-preserving tumour resection in renal cell carcinoma with photodynamic detection by 5-aminolaevulinic acid: preclinical and preliminary clinical results.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Active and higher intracellular uptake of 5-aminolevulinic acid in tumors may be inhibited by glycine.
Topics: Aminolevulinic Acid; Animals; Biological Transport; Cricetinae; Deferoxamine; Diffusion Chambers, Culture; Glycine; Male; Melanoma, Amelanotic; Mesocricetus; Neoplasm Transplantation; Phenanthrolines; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence | 1999 |
Rodent fibroblast model for studies of response of malignant cells to exogenous 5-aminolevulinic acid.
Topics: 3T3 Cells; Aminolevulinic Acid; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Female; Fibroblasts; Fibrosarcoma; Flow Cytometry; Fluorescent Dyes; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Oncogenes; Phenotype; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Signal Transduction; Species Specificity; Spectrometry, Fluorescence; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1999 |
Delta-aminolaevulinic acid-induced photodynamic therapy inhibits protoporphyrin IX biosynthesis and reduces subsequent treatment efficacy in vitro.
Topics: Aminolevulinic Acid; Animals; Cell Division; Cell Survival; Hydroxymethylbilane Synthase; Light; Photosensitizing Agents; Protoporphyrins; Rats; Treatment Outcome | 1999 |
Photodynamically induced effects in colon carcinoma cells (WiDr) by endogenous photosensitizers generated by incubation with 5-aminolaevulinic acid.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Biomarkers, Tumor; Colonic Neoplasms; Fluorescent Dyes; Heptanoates; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Oxygen Consumption; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rhodamine 123; Time Factors; Tumor Cells, Cultured | 1999 |
Comparative effect of ALA derivatives on protoporphyrin IX production in human and rat skin organ cultures.
Topics: Aminolevulinic Acid; Animals; Female; Humans; Microscopy, Fluorescence; Organ Culture Techniques; Protoporphyrins; Rats; Rats, Wistar; Skin | 1999 |
Optimisation of the formation and distribution of protoporphyrin IX in the urothelium: an in vitro approach.
Topics: Aminolevulinic Acid; Animals; Humans; Photosensitizing Agents; Protoporphyrins; Swine; Tissue Distribution; Urothelium | 1999 |
Three-dimensional in vitro cocultivation of lung carcinoma cells with human bronchial organ culture as a model for bronchial carcinoma.
Topics: Aminolevulinic Acid; Bronchi; Bronchial Neoplasms; Carcinoma, Non-Small-Cell Lung; Coculture Techniques; Humans; Kinetics; Lung Neoplasms; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Models, Biological; Organ Culture Techniques; Protoporphyrins; Time Factors; Tumor Cells, Cultured | 1999 |
Endoscopic photodynamic diagnosis: oral aminolevulinic acid is a marker of GI cancer and dysplastic lesions.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Duodenal Neoplasms; Endoscopy, Digestive System; Equipment Design; Esophageal Neoplasms; Female; Fluorescence; Humans; Male; Middle Aged; Neoplasm Staging; Photography; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Stomach Neoplasms | 1999 |
Protoporphyrin IX fluorescence kinetics in C6 glioblastoma cells after delta-aminolevulinic acid incubation: effect of a protoporphyrinogen oxidase inhibitor.
Topics: Aminolevulinic Acid; Animals; Enzyme Inhibitors; Fluorescence; Glioblastoma; Humans; Kinetics; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Photosensitizing Agents; Protoporphyrinogen Oxidase; Protoporphyrins; Rats; Sulfonamides; Triazoles; Tumor Cells, Cultured | 1999 |
delta-Aminolaevulinic acid-induced porphyrin synthesis and photodynamic inactivation of Escherichia coli B.
Topics: Aminolevulinic Acid; Coproporphyrins; Darkness; Dose-Response Relationship, Drug; Escherichia coli; Mesoporphyrins; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Time Factors | 1999 |
[Visualizing carcinomas of the mouth cavity by stimulating synthesis of fluorescent protoporphyrin IX].
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Female; Humans; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasm Staging; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence | 1999 |
Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA.
Topics: Aminolevulinic Acid; Breast Neoplasms; DNA; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylbilane Synthase; Mesothelioma; Photochemotherapy; Plasmids; Protoporphyrins; Transfection; Tumor Cells, Cultured | 1999 |
The temperature dependence of protoporphyrin IX production in cells and tissues.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Cell Line; Cricetinae; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Protoporphyrins; Skin; Skin Neoplasms; Temperature | 1999 |
Relationship of delta-aminolevulinic acid-induced protoporphyrin IX levels to mitochondrial content in neoplastic cells in vitro.
Topics: Aminolevulinic Acid; Animals; Electron Transport Complex IV; Ferrochelatase; Fluorescent Dyes; Humans; Hydroxymethylbilane Synthase; Mice; Mitochondria; Neoplasms; Oxidoreductases; Photochemotherapy; Photosensitizing Agents; Porphobilinogen Synthase; Protoporphyrins; Tumor Cells, Cultured | 1999 |
Preclinical study in cats of the pro-photosensitizer 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Biotransformation; Carcinoma, Squamous Cell; Cat Diseases; Cats; Cell Line; Female; Kidney; Male; Orchiectomy; Ovariectomy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms | 1999 |
Effect of estrogenic perturbations on delta-aminolevulinic acid-induced porphobilinogen deaminase and protoporphyrin IX levels in rat Harderian glands, liver, and R3230AC tumors.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Estrogen Antagonists; Estrogens; Female; Harderian Gland; Hydroxymethylbilane Synthase; Liver; Mammary Neoplasms, Experimental; Ovariectomy; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred F344; Tamoxifen | 1999 |
Detection of squamous cell carcinoma of the oral cavity by imaging 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Adult; Aged; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Humans; Middle Aged; Mouth; Mouth Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Solutions; Spectrometry, Fluorescence; Time Factors | 2000 |
Local 5-aminolevulinic acid application for laser light-induced fluorescence diagnosis of early staged colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Aminolevulinic Acid; Animals; Biomarkers, Tumor; Colon; Colonic Neoplasms; Colonoscopy; Fluorescence; Lasers; Male; Photosensitizing Agents; Predictive Value of Tests; Protoporphyrins; Rats; Rats, Wistar; Therapeutic Irrigation | 2000 |
5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells.
Topics: Aminolevulinic Acid; Bronchi; Cell Line; Humans; Hydrogen-Ion Concentration; Kinetics; Lung Neoplasms; Photosensitizing Agents; Protoporphyrins; Respiratory Mucosa; Structure-Activity Relationship; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2000 |
Decreased and increased expression of the subunit CHL I diminishes Mg chelatase activity and reduces chlorophyll synthesis in transgenic tobacco plants.
Topics: Aminolevulinic Acid; Blotting, Northern; Blotting, Western; Catalytic Domain; Chlorophyll; Light-Harvesting Protein Complexes; Lyases; Nicotiana; Photosynthetic Reaction Center Complex Proteins; Plants, Genetically Modified; Plants, Toxic; Protoporphyrins; Pyrroles; Tetrapyrroles | 2000 |
A study of aminolevulinic acid-induced protoporphyrin IX fluorescence kinetics in the canine oral cavity.
Topics: Aminolevulinic Acid; Animals; Dogs; Dose-Response Relationship, Drug; Face; Female; Fiber Optic Technology; Fluorescence; Gingiva; Heme; Image Processing, Computer-Assisted; Mouth; Mouth Mucosa; Photosensitizing Agents; Protoporphyrins; Random Allocation; Skin; Spectrometry, Fluorescence; Time Factors; Tongue | 2000 |
The morphological changes in rat bladder after photodynamic therapy with 5-aminolaevulinic acid-induced protoporphyrin IX.
Topics: Aminolevulinic Acid; Animals; Female; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Urinary Bladder Diseases | 2000 |
Photodynamic therapy of human glioma spheroids using 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Glioblastoma; Humans; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins; Spheroids, Cellular | 2000 |
Photodynamic therapy of cutaneous lymphoma using 5-aminolevulinic acid topical application.
Topics: Abdomen; Administration, Topical; Adult; Aged; Aminolevulinic Acid; Facial Dermatoses; Humans; Lymphoma, T-Cell, Cutaneous; Male; Mycosis Fungoides; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence | 2000 |
Effect of photodynamic therapy in combination with ionizing radiation on human squamous cell carcinoma cell lines of the head and neck.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Combined Modality Therapy; DNA; Dose-Response Relationship, Radiation; Gamma Rays; Head and Neck Neoplasms; Humans; Kinetics; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation, Ionizing; Time Factors; Tumor Cells, Cultured | 2000 |
Porphyrin biosynthesis in human Barrett's oesophagus and adenocarcinoma after ingestion of 5-aminolaevulinic acid.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Female; Ferrochelatase; Heme; Humans; Hydroxymethylbilane Synthase; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Porphobilinogen; Porphyrins; Protoporphyrins | 2000 |
Phototransformations of 5-aminolevulinic acid-induced protoporphyrin IX in vitro: a spectroscopic study.
Topics: Aminolevulinic Acid; Humans; In Vitro Techniques; Lasers; Photochemistry; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2000 |
Intravesical administration of 5-aminolevulinic acid (5-ALA). Safety and pharmacokinetics of 5-ALA and its metabolite protoporphyrin IX.
Topics: Administration, Intravesical; Adult; Aged; Aminolevulinic Acid; Female; Humans; Male; Middle Aged; Protoporphyrins; Urinary Bladder; Urinary Bladder Neoplasms | 2000 |
Genes involved in the destruction of leukaemic cells by induced photosensitivity.
Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; DNA, Complementary; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Light; Oligonucleotide Array Sequence Analysis; Photosensitizing Agents; Protoporphyrins; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Protoporphyrin IX fluorescence kinetics and localization after topical application of ALA pentyl ester and ALA on hairless mouse skin with UVB-induced early skin cancer.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Fluorescence; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms | 2000 |
Initial experience in the treatment of oral leukoplakia with high-dose vitamin A and follow-up 5-aminolevulinic acid induced protoporphyrin IX fluorescence.
Topics: Adult; Aminolevulinic Acid; Anticarcinogenic Agents; Diterpenes; Female; Fluorescence; Humans; Leukoplakia, Oral; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Retinyl Esters; Vitamin A | 2000 |
Apoptosis induced in vivo by photodynamic therapy in normal brain and intracranial tumour tissue.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Dihematoporphyrin Ether; Indoles; Male; Mesoporphyrins; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rabbits; Radiation-Sensitizing Agents | 2000 |
A key role for the mitochondrial benzodiazepine receptor in cellular photosensitisation with delta-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fluorescence; Heme; Humans; Mitochondria; Photosensitizing Agents; Protoporphyrins; Rats; Receptors, GABA-A; Tumor Cells, Cultured | 2000 |
Comparison of the pharmacokinetics and phototoxicity of protoporphyrin IX metabolized from 5-aminolevulinic acid and two derivatives in human skin in vivo.
Topics: Adult; Aminolevulinic Acid; Humans; Iontophoresis; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin | 2000 |
Accumulation of protoporphyrin-IX (PpIX) in leukemic cell lines following induction by 5-aminolevulinic acid (ALA).
Topics: Aminolevulinic Acid; Animals; Cattle; Culture Media; Ferrochelatase; HL-60 Cells; Humans; Jurkat Cells; Kinetics; Leukemia; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2000 |
Photosensitization of pancreatic tumour cells by delta-aminolaevulinic acid esters.
Topics: Aminolevulinic Acid; Animals; Biological Transport, Active; Carrier Proteins; Esters; Pancreatic Neoplasms; Peptide Transporter 1; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Spectrometry, Fluorescence; Structure-Activity Relationship; Symporters; Tumor Cells, Cultured | 2000 |
Fractionated illumination in oesophageal ALA-PDT: effect on ferrochelatase activity.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Radiation; Esophagus; Ferrochelatase; Hydroxymethylbilane Synthase; Light; Male; Mucous Membrane; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar | 2000 |
Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: differences in protoporphyrin IX fluorescence kinetics and the role of the stratum corneum.
Topics: Aminolevulinic Acid; Animals; Female; Fluorescence; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2000 |
Ethylene glycol and amino acid derivatives of 5-aminolevulinic acid as new photosensitizing precursors of protoporphyrin IX in cells.
Topics: Amino Acids; Aminolevulinic Acid; Aminopeptidases; Animals; Dipeptides; Ethylene Glycols; Fluorescence; Glutamyl Aminopeptidase; Humans; Photosensitizing Agents; Protein Precursors; Protoporphyrins; Rats; Tumor Cells, Cultured | 2000 |
Fluorescence detection of small gastrointestinal tumours: principles, technique, first clinical experience.
Topics: Aminolevulinic Acid; Endoscopy; Fluorescence; Gastrointestinal Neoplasms; Humans; Laparoscopy; Peritoneal Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Stomach Neoplasms | 2000 |
Topical 5-aminolevulinic acid-photodynamic therapy of hairless mouse skin using two-fold illumination schemes: PpIX fluorescence kinetics, photobleaching and biological effect.
Topics: Aminolevulinic Acid; Animals; Fluorescence; Kinetics; Mice; Mice, Hairless; Photochemotherapy; Protoporphyrins; Skin | 2000 |
Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo.
Topics: Aminolevulinic Acid; Animals; Female; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred F344; Skin; Spectrometry, Fluorescence | 2001 |
Regulation of protoporphyrin IX biosynthesis by intraplastidic compartmentalization and adenosine triphosphate.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Aminolevulinic Acid; Chemical Fractionation; Chloroplasts; Cucumis sativus; Dithiothreitol; Hydroxamic Acids; Hydroxymethylbilane Synthase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plastids; Porphobilinogen Synthase; Protoporphyrinogen Oxidase; Protoporphyrins; Thylakoids | 2000 |
Oxygen monitoring during 5-aminolaevulinic acid induced photodynamic therapy in normal rat colon. Comparison of continuous and fractionated light regimes.
Topics: Aminolevulinic Acid; Animals; Colon; Female; Light; Monitoring, Physiologic; Necrosis; Oxygen; Photobiology; Photochemotherapy; Protoporphyrins; Rats; Rats, Wistar | 2000 |
On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters.
Topics: Adenocarcinoma; Administration, Cutaneous; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Protoporphyrins; Skin; Spectrometry, Fluorescence | 2001 |
Synergistic toxicity of delta-aminolaevulinic acid-induced protoporphyrin IX used for photodiagnosis and hypericum extract, a herbal antidepressant.
Topics: Aminolevulinic Acid; Drug Eruptions; Drug Synergism; Female; Humans; Hypericum; Middle Aged; Photosensitivity Disorders; Photosensitizing Agents; Plants, Medicinal; Protoporphyrins | 2001 |
Photodynamic DNA damage mediated by delta-aminolevulinic acid-induced porphyrins.
Topics: Aminolevulinic Acid; Animals; DNA Damage; Humans; Mice; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2001 |
Photomodification of the electrical properties of the plasma membrane: a comparison between 6 different membrane-active photosensitizers.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Membrane; Dihematoporphyrin Ether; Electric Conductivity; Indoles; Ion Transport; Isoindoles; Kidney; Light; Membrane Potentials; Methylene Blue; Opossums; Organometallic Compounds; Patch-Clamp Techniques; Photochemistry; Photosensitizing Agents; Protoporphyrins; Pyrimidinones; Rose Bengal; Zinc Compounds | 2001 |
Biosynthesis and photodynamic efficacy of protoporphyrin IX (PpIX) generated by 5-aminolevulinic acid (ALA) or its hexylester (hALA) in rat bladder carcinoma cells.
Topics: Aminolevulinic Acid; Animals; Cell Extracts; Cell Survival; Culture Media; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2000 |
Optimization of differential photodynamic effectiveness between normal and tumor urothelial cells using 5-aminolevulinic acid-induced protoporphyrin IX as sensitizer.
Topics: Aminolevulinic Acid; Flow Cytometry; Humans; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured; Urinary Bladder; Urinary Bladder Neoplasms | 2001 |
A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose-controlled delivery of the prodrugs 5-aminolaevulinic acid and 5-aminolaevulinic acid-n-pentylester.
Topics: Adult; Aminolevulinic Acid; Dose-Response Relationship, Drug; Erythema; Female; Humans; Iontophoresis; Male; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin | 2001 |
Routine experimental system for defining conditions used in photodynamic therapy and fluorescence photodetection of (non-) neoplastic epithelia.
Topics: Aminolevulinic Acid; Animals; Cell Death; Culture Techniques; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Mucous Membrane; Neoplasms; Paranasal Sinuses; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Respiratory Mucosa; Sheep; Swine; Time Factors; Urinary Bladder | 2001 |
Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence microscopic studies.
Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Squamous Cell; Fluorescence; Humans; Microscopy, Fluorescence; Mouth Neoplasms; Photosensitizing Agents; Protoporphyrins; Staining and Labeling | 2001 |
Evaluation of protoporphyrin IX production, phototoxicity and cell death pathway induced by hexylester of 5-aminolevulinic acid in Reh and HPB-ALL cells.
Topics: Aminolevulinic Acid; Cell Death; Flow Cytometry; Humans; Leukemia, B-Cell; Lymphoma, T-Cell; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2001 |
Modulator of heme biosynthesis induces apoptosis in leukemia cells.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Cycle; Cell Division; Cell Membrane Permeability; Cell Survival; Darkness; DNA; Flow Cytometry; Hylobates; Iron Chelating Agents; Leukemia; Light; Lymphoma; Matched-Pair Analysis; Nucleosomes; Phenanthrolines; Photosensitizing Agents; Protoporphyrins; Receptors, GABA-A; Tumor Cells, Cultured | 2001 |
5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells.
Topics: Aminolevulinic Acid; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dermatitis, Phototoxic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Extracellular Space; Ferrochelatase; Half-Life; Humans; Leukemia; Photochemotherapy; Protoporphyrins; Tumor Cells, Cultured | 2001 |
The photosensitizing effect of the photoproduct of protoporphyrin IX.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Membrane; Humans; Methylene Blue; Photochemotherapy; Propidium; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2001 |
An affordable, portable fluorescence imaging device for skin lesion detection using a dual wavelength approach for image contrast enhancement and aminolaevulinic acid-induced protoporphyrin IX. Part I. Design, spectral and spatial characteristics.
Topics: Aminolevulinic Acid; Equipment Design; Humans; Image Processing, Computer-Assisted; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Skin Diseases; Spectrometry, Fluorescence | 2001 |
An affordable, portable fluorescence imaging device for skin lesion detection using a dual wavelength approach for image contrast enhancement and aminolaevulinic acid-induced protoporphyrin IX. Part II. In vivo testing.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Female; Humans; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Spectrometry, Fluorescence | 2001 |
In vivo pharmacokinetics of protoporphyrin IX accumulation following intracutaneous injection of 5-aminolevulinic acid.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Drug Interactions; Female; Fluorescence; Injections; Kinetics; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Swine | 2001 |
Fluorescence spectroscopy of normal mouse skin exposed to 5-aminolaevulinic acid and red light.
Topics: Aminolevulinic Acid; Animals; Female; Fluorescence; Kinetics; Light; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence | 2001 |
Fractionated illumination for oesophageal ALA-PDT: effect on blood flow and PpIX formation.
Topics: Aminolevulinic Acid; Animals; Barrett Esophagus; Esophagus; Male; Photochemotherapy; Protoporphyrins; Rats; Rats, Wistar | 2001 |
ALA- and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumour spheroids.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Esters; Mammary Neoplasms, Experimental; Mice; Microscopy, Fluorescence; Oxygen; Photosensitizing Agents; Protoporphyrins; Spheroids, Cellular | 2001 |
In vitro and in vivo expression of protoporphyrin IX induced by lipophilic 5-aminolevulinic acid derivatives.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cells, Cultured; HeLa Cells; Humans; Keratinocytes; Kinetics; Male; Mice; Mice, Inbred C3H; Protoporphyrins; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
5-Aminolevulinic acid-based photochemical internalization of the immunotoxin MOC31-gelonin generates synergistic cytotoxic effects in vitro.
Topics: Acetylglucosaminidase; Aminolevulinic Acid; Humans; Immunotoxins; In Vitro Techniques; Photochemistry; Photochemotherapy; Plant Proteins; Protoporphyrins; Ribosome Inactivating Proteins, Type 1; Tumor Cells, Cultured | 2001 |
A mathematical evaluation of dose-dependent PpIX fluorescence kinetics in vivo.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Fluorescence; Kinetics; Mathematics; Mice; Models, Biological; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2001 |
Oral aminolevulinic acid induces protoporphyrin IX fluorescence in psoriatic plaques and peripheral blood cells.
Topics: Administration, Oral; Aminolevulinic Acid; Blood Cells; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Skin | 2001 |
Autofluorescence imaging to optimize 5-ALA-induced fluorescence endoscopy of bladder carcinoma.
Topics: Administration, Intravesical; Aminolevulinic Acid; Biopsy; Cystoscopy; Equipment Design; False Positive Reactions; Fluorescence; Humans; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium | 2001 |
Intraoperative fluorescence visualization of the parathyroid gland in rats.
Topics: Aminolevulinic Acid; Animals; Biopsy; Female; Fluorescence; Intraoperative Period; Parathyroid Glands; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred Strains | 2001 |
Fluorescence induced with 5-aminolevulinic acid for the endoscopic detection and follow-up of esophageal lesions.
Topics: Administration, Oral; Aged; Aminolevulinic Acid; Biopsy; Esophageal Neoplasms; Esophagoscopy; Female; Fluorescence; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity | 2001 |
Photodynamic effects induced by aminolevulinic acid esters on human cervical carcinoma cells in culture.
Topics: Aminolevulinic Acid; Annexin A5; Apoptosis; Carcinoma in Situ; Cell Membrane; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Esters; Female; Flow Cytometry; Humans; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, X-Ray Emission; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2001 |
Effects of 5-aminolaevulinic acid on human ovarian cancer cells and human vascular endothelial cells in vitro.
Topics: Aminolevulinic Acid; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cystadenocarcinoma, Mucinous; Dose-Response Relationship, Drug; Endothelium, Vascular; Epithelial Cells; Female; Humans; Kinetics; Light; Mitochondria; Ovarian Neoplasms; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Tumor Cells, Cultured; Umbilical Veins | 2001 |
Protoporphyrin IX distribution following local application of 5-aminolevulinic acid and its esterified derivatives in the tissue layers of the normal rat colon.
Topics: Aminolevulinic Acid; Animals; Colon; Female; Kinetics; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Rats; Tissue Distribution | 2001 |
The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines.
Topics: Adenocarcinoma; Aminolevulinic Acid; Dose-Response Relationship, Drug; Esters; Fibroblasts; Flow Cytometry; Humans; Kinetics; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2001 |
Endogenous production of protoporphyrin IX induced by 5-aminolevulinic acid in leukemia cells.
Topics: Aminolevulinic Acid; Animals; Leukemia, Experimental; Leukemia, Myeloid; Mice; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2001 |
ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitization.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Female; Kidney; Liver; Mice; Neoplasms, Experimental; Papilloma; Photochemotherapy; Protoporphyrins; Skin; Skin Neoplasms; Spleen | 2001 |
A comparative study of normal inspection, autofluorescence and 5-ALA-induced PPIX fluorescence for oral cancer diagnosis.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Female; Fluorescence; Humans; Middle Aged; Mouth Neoplasms; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Time Factors | 2002 |
The influence of UV exposure on 5-aminolevulinic acid-induced protoporphyrin IX production in skin.
Topics: Aminolevulinic Acid; Animals; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Photobiology; Photochemotherapy; Protoporphyrins; Skin; Ultraviolet Rays | 2001 |
Laparoscopic fluorescence diagnosis for intraabdominal fluorescence targeting of peritoneal carcinosis experimental studies.
Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Fluorescence; Laparoscopy; Neoplasm Staging; Peritoneal Neoplasms; Photosensitizing Agents; Protoporphyrins; Random Allocation; Rats; Rats, Inbred Strains; Tumor Cells, Cultured | 2002 |
Isolation and characterization of a cDNA from soybean and its homolog from Escherichia coli, which both complement the light sensitivity of Escherichia coli hemH mutant strain VS101.
Topics: Aminolevulinic Acid; Bacteriophages; DNA, Bacterial; DNA, Complementary; Escherichia coli; Ferrochelatase; Gene Deletion; Genetic Complementation Test; Glycine max; Heme; Light; Lysogeny; Mutation; Open Reading Frames; Protoporphyrins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transformation, Genetic | 2001 |
PpIX fluorescence kinetics and increased skin damage after intracutaneous injection of 5-aminolevulinic acid and repeated illumination.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Radiation; Female; Fluorescence; Injections, Intradermal; Kinetics; Light; Osmolar Concentration; Photosensitizing Agents; Protoporphyrins; Retreatment; Skin; Skin Temperature; Swine; Tissue Distribution; Wound Healing | 2002 |
Potential efficacy of a delta 5-aminolevulinic acid thermosetting gel formulation for use in photodynamic therapy of lesions of the gastrointestinal tract.
Topics: Aminolevulinic Acid; Animals; Barrett Esophagus; Drug Stability; Gastric Mucosa; Gels; Male; Mice; Mice, Inbred Strains; Photochemotherapy; Photosensitizing Agents; Poloxamer; Prodrugs; Protoporphyrins; Spectrometry, Fluorescence; Temperature; Time Factors | 2002 |
Oxygen-mediated regulation of porphobilinogen formation in Rhodobacter capsulatus.
Topics: Aminolevulinic Acid; Bacterial Proteins; Bacteriochlorophylls; Escherichia coli Proteins; Genes, Bacterial; Hemin; Hydroxymethylbilane Synthase; Mixed Function Oxygenases; Molecular Sequence Data; Mutation; Oxygen; Porphobilinogen; Porphobilinogen Synthase; Protoporphyrins; Rhodobacter capsulatus; Transcription, Genetic | 2002 |
Systemic component of protoporphyrin IX production in nude mouse skin upon topical application of aminolevulinic acid depends on the application conditions.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Mice; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Skin | 2002 |
The fluorescence biodistribution and kinetics of aminolevulinic acid induced protoporphyrin IX in the bladder of a rat model with orthotopic urothelial carcinoma.
Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Carcinoma, Transitional Cell; Female; Fluorescence; Injections, Intravenous; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Tissue Distribution; Urinary Bladder Neoplasms | 2002 |
Aminolaevulinic acid-induced photodynamic therapy: cellular responses to glucose starvation.
Topics: Aminolevulinic Acid; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Glucose; Humans; Light; Phototherapy; Protoporphyrins; Tumor Cells, Cultured | 2002 |
Localization and staging of cervical intraepithelial neoplasia using double ratio fluorescence imaging.
Topics: Adult; Aminolevulinic Acid; Colposcopy; Female; Humans; Middle Aged; Monte Carlo Method; Neoplasm Staging; Optics and Photonics; Protoporphyrins; Spectrometry, Fluorescence; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2002 |
PDT effects of m-THPC and ALA, phototoxicity and apoptosis.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Survival; DNA Fragmentation; Light; Mesoporphyrins; Mice; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Tumor Cells, Cultured | 2002 |
In vitro/in vivo correlations between transdermal delivery of 5-aminolaevulinic acid and cutaneous protoporphyrin IX accumulation and effect of formulation.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Administration Schedule; Epidermis; Female; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin; Skin Absorption | 2002 |
Quantitative model calculation of the time-dependent protoporphyrin IX concentration in normal human epidermis after delivery of ALA by passive topical application or lontophoresis.
Topics: Administration, Topical; Aminolevulinic Acid; Epidermis; Humans; Iontophoresis; Models, Biological; Protoporphyrins | 2002 |
Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Fluorescence; Kinetics; Mice; Mice, Hairless; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Ultraviolet Rays | 2002 |
Photodynamic therapy of human Barrett's cancer using 5-aminolaevulinic acid-induced protoporphyrin IX: an in-vivo dosimetry study in athymic nude mice.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Barrett Esophagus; Esophageal Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiometry | 2002 |
Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Antineoplastic Agents; Carboxylesterase; Carboxylic Ester Hydrolases; Carcinoma; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Esters; Female; Injections, Intravenous; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Porphyrins; Prodrugs; Protoporphyrins; Tumor Cells, Cultured | 2002 |
Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Drug Administration Schedule; Mice; Mice, Hairless; Microscopy, Fluorescence; Neoplasms, Radiation-Induced; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Time Factors; Ultraviolet Rays | 2002 |
In vivo pharmacokinetics of 8-aminolevulinic acid-induced protoporphyrin IX during pre- and post-photodynamic therapy in 7,12-dimethylbenz(a)nthracene-treated skin carcinogenesis in Swiss mice: a comparison by three-compartment model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Female; Mice; Models, Biological; Photochemotherapy; Protoporphyrins; Skin Neoplasms | 2002 |
Comparison of 5-aminolevulinic acid and its hexylester mediated photodynamic action on human hepatoma cells.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2002 |
[5-Aminolevulinic acid esters based photodynamic therapy].
Topics: Aminolevulinic Acid; Esters; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2002 |
Kinetics of 5-aminolevulinic acid-induced fluorescence in organ cultures of bronchial epithelium and tumor.
Topics: Aminolevulinic Acid; Analysis of Variance; Bronchi; Bronchial Neoplasms; Carcinoma, Non-Small-Cell Lung; Coculture Techniques; Epithelial Cells; Fluorescence; Humans; Kinetics; Lung Neoplasms; Microscopy, Fluorescence; Organ Culture Techniques; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrum Analysis | 2002 |
Detection of neoplasms in the oral cavity by digitized endoscopic imaging of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aminolevulinic Acid; Endoscopy; Female; Fluorescent Dyes; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Mouth Neoplasms; Photosensitizing Agents; Protoporphyrins; Software | 2002 |
Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice.
Topics: Administration, Topical; Alamethicin; Aminolevulinic Acid; Animals; Cell Division; Hutchinson's Melanotic Freckle; Melanoma, Experimental; Mice; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2002 |
Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagoscopy; Esophagus; Humans; Lasers; Male; Middle Aged; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence | 2002 |
Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Esters; Female; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Protoporphyrins; Skin | 2002 |
Temperature effect on accumulation of protoporphyrin IX after topical application of 5-aminolevulinic acid and its methylester and hexylester derivatives in normal mouse skin.
Topics: Administration, Topical; Aminolevulinic Acid; Anesthesia; Animals; Esters; Mice; Protoporphyrins; Skin; Spectrometry, Fluorescence; Temperature | 2002 |
Comparison of normal piglet bladder damage after PDT with oral or intravesical administration of ALA.
Topics: Administration, Intravesical; Administration, Oral; Aminolevulinic Acid; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Swine; Tissue Distribution; Urinary Bladder | 2002 |
Hyperresistance to photosensitized lipid peroxidation and apoptotic killing in 5-aminolevulinate-treated tumor cells overexpressing mitochondrial GPX4.
Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Survival; Flow Cytometry; Free Radicals; Glutathione Peroxidase; Humans; Lipid Peroxidation; Lipid Peroxides; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Phospholipid Hydroperoxide Glutathione Peroxidase; Phospholipids; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Rhodamine 123; Subcellular Fractions; Time Factors; Transfection; Tumor Cells, Cultured | 2002 |
Gene expression pattern following photodynamic treatment of the carcinoma cell line A-431 analysed by cDNA arrays.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Survival; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, jun; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Humans; Membrane Proteins; Necrosis; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-fos; Protoporphyrins; RNA, Messenger; Subcellular Fractions; Tumor Cells, Cultured | 2002 |
Differentiation enhances aminolevulinic acid-dependent photodynamic treatment of LNCaP prostate cancer cells.
Topics: Aminolevulinic Acid; Cell Differentiation; Flow Cytometry; Humans; Male; Metribolone; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Testosterone Congeners; Tretinoin; Tumor Cells, Cultured; Vitamin D | 2002 |
Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Esters; Female; Mice; Mice, Inbred BALB C; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence; Tissue Distribution | 2003 |
[Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid].
Topics: Administration, Inhalation; Administration, Oral; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Humans; Laryngeal Neoplasms; Mouth Mucosa; Mouth Neoplasms; Neoplasm Staging; Oropharyngeal Neoplasms; Precancerous Conditions; Prognosis; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence | 2002 |
Metabolic characterization of tumor cell-specific protoporphyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Fibroblasts; Humans; Iron; Light; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Receptors, Transferrin; Spectrometry, Fluorescence | 2002 |
Transfer of protoporphyrin IX between cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Communication; Cell Line, Tumor; Colonic Neoplasms; Humans; Jurkat Cells; Leukemia; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; T-Lymphocytes; Time Factors | 2002 |
Time gated fluorescence spectroscopy in Barrett's oesophagus.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Biomarkers, Tumor; Biopsy; Diagnosis, Differential; Esophageal Neoplasms; Esophagus; Female; Humans; Intestines; Male; Metaplasia; Middle Aged; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Signal Processing, Computer-Assisted; Spectrometry, Fluorescence; Tumor Suppressor Protein p53 | 2003 |
A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder cancer.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biological Transport, Active; Carcinoma; Cystoscopy; Ferrochelatase; Humans; Hydroxymethylbilane Synthase; Image Processing, Computer-Assisted; Injections, Intravenous; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Transplantation, Heterologous; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2003 |
Fluorescence confocal microscopy and image analysis of bladder cancer using 5-aminolevulinic acid.
Topics: Administration, Intravesical; Aminolevulinic Acid; Biomarkers, Tumor; Carcinoma in Situ; Carcinoma, Transitional Cell; Humans; Image Processing, Computer-Assisted; Light; Microscopy, Confocal; Microscopy, Fluorescence; Mucous Membrane; Muscle, Smooth; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms; Urothelium | 2003 |
Phototoxic effects of 635-nm light on canine transitional cell carcinoma cells incubated with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Transitional Cell; Cell Survival; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Lasers; Light; Photochemotherapy; Protoporphyrins; Time Factors; Tumor Cells, Cultured | 2003 |
Acceleration of ALA-induced PpIX fluorescence development in the oral mucosa.
Topics: Administration, Topical; Aminolevulinic Acid; Analysis of Variance; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Mouth Mucosa; Mouth Neoplasms; Photosensitizing Agents; Probability; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence | 2003 |
Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for photosensitizers in photodynamic therapy.
Topics: Aminolevulinic Acid; Cells, Cultured; Dipeptides; Endothelium, Vascular; Humans; Hydrolysis; Neprilysin; Peptide Hydrolases; Peptides; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2003 |
In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Kinetics; Lasers; Microscopy, Fluorescence; Nasopharyngeal Neoplasms; Necrosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2002 |
Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo.
Topics: Aminolevulinic Acid; Animals; Female; Humans; Light; Models, Biological; Models, Chemical; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Nude; Skin; Spectrometry, Fluorescence; Tissue Distribution; Tumor Cells, Cultured | 2002 |
Dose and timing of the first light fraction in two-fold illumination schemes for topical ALA-mediated photodynamic therapy of hairless mouse skin.
Topics: Aminolevulinic Acid; Animals; Female; Kinetics; Mice; Mice, Hairless; Necrosis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2003 |
Two course illuminating scheme improves aminolevulinic acid photodynamic therapy in cell cultures.
Topics: Aminolevulinic Acid; Barrett Esophagus; Cell Line, Transformed; Cells, Cultured; Ferrochelatase; Humans; Hydroxymethylbilane Synthase; Light; Photochemotherapy; Porphyrins; Protoporphyrins; Time Factors | 2002 |
Production of protoporphyrin IX from 5-aminolevulinic acid and two of its esters in cells in vitro and tissues in vivo.
Topics: Aminolevulinic Acid; Animals; Cell Survival; Dose-Response Relationship, Drug; Female; Kinetics; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Protein Binding; Protoporphyrins; Spectrometry, Fluorescence; Time Factors | 2002 |
Improving the use of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PPIX) for the gastrointestinal tract by esterification--an in vitro study.
Topics: Aminolevulinic Acid; Cell Line; Colon; Digestive System; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Flow Cytometry; Humans; Kinetics; Light; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence; Time Factors; Tumor Cells, Cultured | 2002 |
Photodynamic diagnosis of ovarian cancer using hexaminolaevulinate: a preclinical study.
Topics: Aminolevulinic Acid; Animals; Diagnostic Techniques and Procedures; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelium; Feasibility Studies; Female; Fluorescence; Neoplasm Staging; Ovarian Neoplasms; Peritoneal Neoplasms; Photosensitizing Agents; Prognosis; Protoporphyrins; Rats; Rats, Inbred F344; Sensitivity and Specificity | 2003 |
Fluorescence endoscopy for the detection of low and high grade dysplasia in ulcerative colitis using systemic or local 5-aminolaevulinic acid sensitisation.
Topics: Adult; Aged; Aminolevulinic Acid; Biopsy; Colitis, Ulcerative; Endoscopy, Gastrointestinal; Feasibility Studies; Female; Fluorescence; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity | 2003 |
Photodynamic effects of 5-aminolevulinic acid and its hexylester on several cell lines.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Mitochondria; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2003 |
Selective accumulation of ALA-induced PpIX and photodynamic effect in chemically induced hepatocellular carcinoma.
Topics: Alkylating Agents; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Lasers; Liver; Liver Neoplasms, Experimental; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Spectrometry, Fluorescence | 2003 |
Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid.
Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Carcinoma in Situ; Esophageal Neoplasms; Esophagoscopy; Female; Fluorescence; Humans; Male; Middle Aged; Photosensitizing Agents; Predictive Value of Tests; Protoporphyrins; Radiography; Reproducibility of Results | 2003 |
Aminolaevulinic acid-induced protoporphyrin IX pharmacokinetics in central and peripheral arteries of the rat.
Topics: Aminolevulinic Acid; Animals; Arteries; Male; Mitochondria; Porphobilinogen; Protoporphyrins; Rats; Rats, Wistar; Time Factors | 2003 |
ALA (5-aminolevulinic acid)-induced protoporphyrin IX fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer.
Topics: Adult; Aged; Aminolevulinic Acid; Diagnosis, Differential; Female; Fluorescence; Humans; Laryngeal Neoplasms; Laryngoscopy; Laser Therapy; Male; Middle Aged; Neoplasm Staging; Pharyngeal Neoplasms; Photosensitizing Agents; Precancerous Conditions; Prospective Studies; Protoporphyrins; Risk Assessment; Sensitivity and Specificity; Treatment Outcome | 2004 |
[Effects of inosine on the urinary elimination of coproporphyrin and delta-aminolevulinic acid and on the behavior of erythrocytic protoporphyrin IX].
Topics: Aminolevulinic Acid; Coproporphyrins; Erythrocytes; Humans; Inosine; Levulinic Acids; Nucleosides; Porphyrins; Protoporphyrins | 1962 |
Monitoring in situ dosimetry and protoporphyrin IX fluorescence photobleaching in the normal rat esophagus during 5-aminolevulinic acid photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Male; Photochemotherapy; Protoporphyrins; Rats; Rats, Wistar; Spectrometry, Fluorescence | 2003 |
Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line; Cerebellum; Glioma; Humans; Neuroblastoma; Photosensitizing Agents; Protoporphyrins; Rats; Tumor Cells, Cultured | 2003 |
In vivo fluorescence kinetics and photodynamic therapy in condylomata acuminata.
Topics: Adult; Aminolevulinic Acid; Condylomata Acuminata; Fluorescence; Humans; Male; Penile Diseases; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors; Treatment Outcome | 2003 |
In vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Humans; Leukemia, Monocytic, Acute; Luminescent Measurements; Photochemotherapy; Protoporphyrins; Reproducibility of Results; Singlet Oxygen; Spectrum Analysis | 2003 |
Protoporphyrin IX-accumulation in human tumor cells following topical ALA- and h-ALA-application in vivo.
Topics: Administration, Topical; Allantois; Aminolevulinic Acid; Animals; Chick Embryo; Female; Humans; Laryngeal Neoplasms; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2003 |
Fluorescence microspectroscopy technique for the study of intracellular protoporphyrin IX dynamics.
Topics: Aminolevulinic Acid; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Fibroblasts; Humans; Intracellular Space; Keratinocytes; Microspectrophotometry; Photoperiod; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2003 |
Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratum.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Cell Survival; Fluorescent Dyes; Glioblastoma; Humans; Microscopy, Fluorescence; Organic Chemicals; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Rotenone; Spectrometry, Fluorescence; Trypsin; Trypsin Inhibitors | 2004 |
Effect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpIX production in human skin.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Hot Temperature; Humans; In Vitro Techniques; Kinetics; Male; Mice; Mice, Hairless; Photochemotherapy; Protoporphyrins; Skin; Skin Temperature | 2004 |
The use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Diagnostic Imaging; Endoscopy; Female; Fluorescence; Humans; Male; Middle Aged; Mouth Neoplasms; Precancerous Conditions; Protoporphyrins; Sensitivity and Specificity | 2004 |
Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - in vivo experiments on the dunning rat tumor model.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Male; Photochemotherapy; Prostatic Neoplasms; Protoporphyrins; Rats | 2004 |
Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma.
Topics: Acetamides; Aminolevulinic Acid; Animals; Antineoplastic Agents; Blotting, Western; Butyrates; Cell Differentiation; Cell Line, Tumor; Flow Cytometry; Hydroxymethylbilane Synthase; Immunohistochemistry; Melanoma, Experimental; Mice; Microscopy, Electron; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2004 |
Influence of CaNa2 EDTA on topical 5-aminolaevulinic acid photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Edetic Acid; Female; Humans; Male; Middle Aged; Photochemotherapy; Protoporphyrins; Skin Neoplasms | 2004 |
Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Microscopy, Fluorescence; Protoporphyrins; Rabbits; Reference Values | 2004 |
In vitro evaluation of the cytotoxic and mutagenic potential of the 5-aminolevulinic acid hexylester-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Chromosome Aberrations; Humans; Light; Micronuclei, Chromosome-Defective; Mitotic Index; Mutagenicity Tests; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectral Karyotyping; Tumor Cells, Cultured | 2004 |
delta-Aminolaevulinic acid mediated photodynamic antimicrobial chemotherapy on Pseudomonas aeruginosa planktonic and biofilm cultures.
Topics: Aminolevulinic Acid; Biofilms; Light; Photochemotherapy; Photosensitizing Agents; Plankton; Prodrugs; Protoporphyrins; Pseudomonas aeruginosa | 2004 |
Effect of 5-aminolevulinic acid on kinetics of protoporphyrin IX production in CHO cells.
Topics: Aminolevulinic Acid; Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Female; Kinetics; Ovary; Protoporphyrins | 2004 |
Confocal endomicroscopic imaging of normal and neoplastic human tongue tissue using ALA-induced-PPIX fluorescence: a preliminary study.
Topics: Aminolevulinic Acid; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Time Factors; Tongue; Tongue Neoplasms | 2004 |
5-aminolevulinic acid-based photodynamic therapy in leukemia cell HL60.
Topics: Aminolevulinic Acid; Annexins; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescence; HL-60 Cells; Humans; Leukemia, Experimental; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Time Factors | 2004 |
Hexaminolevulinate-induced fluorescence endoscopy in patients with rectal adenoma and cancer: a pilot study.
Topics: Adenoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Cell Transformation, Neoplastic; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Dose-Response Relationship, Drug; Feasibility Studies; Female; Fluorescent Dyes; Humans; Intestinal Mucosa; Male; Microscopy, Fluorescence; Middle Aged; Precancerous Conditions; Proctoscopy; Protoporphyrins | 2004 |
5-aminolevulinic acid ester-induced protoporphyrin IX in a murine melanoma cell line.
Topics: Aminolevulinic Acid; Animals; Diffusion; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Melanoma; Mice; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2004 |
Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase.
Topics: Aminolevulinic Acid; Biochemistry; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Histidine; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Iron; Isopropyl Thiogalactoside; Kynurenine; Plasmids; Protoporphyrins; Recombinant Proteins; Temperature; Time Factors; Tryptophan; Tryptophan Oxygenase | 2004 |
Phototoxicity of exogenous protoporphyrin IX and delta-aminolevulinic acid in the photo hen's egg test.
Topics: Aminolevulinic Acid; Animals; Chick Embryo; Dermatitis, Phototoxic; Disease Models, Animal; Forecasting; Hemorrhage; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation Dosage; Risk Assessment; Survival Rate; Time Factors; Ultraviolet Rays; Yolk Sac | 2004 |
Increased brain tumor resection using fluorescence image guidance in a preclinical model.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Microscopy; Models, Animal; Neoplasm, Residual; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Rabbits; Spectrometry, Fluorescence | 2004 |
Time-dependent hexaminolaevulinate induced protoporphyrin IX distribution after topical application in patients with cervical intraepithelial neoplasia: A fluorescence microscopy study.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Female; Humans; Microscopy, Fluorescence; Middle Aged; Photosensitizing Agents; Protoporphyrins; Time Factors; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2004 |
Phototoxicity of 5-aminolevulinic acid in the HeLa cell line as an indicative measure of photodynamic effect after topical administration to gynecological lesions of intraepithelial form.
Topics: Aminolevulinic Acid; Cell Death; Cell Survival; Dermatitis, Phototoxic; Diffusion Chambers, Culture; Epithelium; Female; Genital Diseases, Female; HeLa Cells; Humans; In Vitro Techniques; Isotope Labeling; Light; Photochemotherapy; Proteins; Protoporphyrins; Tissue Adhesives; Vagina | 2004 |
Effect of 5-aminolevulinic acid (ALA) doses and oestrogen/progesterone on protoporphyrin IX (ppIX) accumulation in human endometrial epithelial cells.
Topics: Aminolevulinic Acid; Endometrium; Epithelial Cells; Estradiol; Female; Humans; Progesterone; Protoporphyrins | 2004 |
In vitro metabolism of 5-ALA esters derivatives in hairless mice skin homogenate and in vivo PpIX accumulation studies.
Topics: Aminolevulinic Acid; Animals; Esters; Male; Mice; Mice, Hairless; Photosensitizing Agents; Protoporphyrins; Skin | 2004 |
Effect of oil-in-water emulsions on 5-aminolevulinic acid uptake and metabolism to PpIX in cultured MCF-7 cells.
Topics: Aminolevulinic Acid; Emulsions; Endocytosis; Humans; Oils; Protoporphyrins; Tumor Cells, Cultured; Water | 2004 |
Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling.
Topics: Aminolevulinic Acid; Animals; Biophysics; Cell Line, Tumor; Culture Techniques; Light; Liver; Mice; Microscopy, Electron; Microscopy, Polarization; Mitochondria; Mitochondrial Swelling; Models, Statistical; Oxidative Stress; Oxygen Consumption; Protoporphyrins; Rabbits; Scattering, Radiation; Time Factors | 2005 |
ABCG2-mediated transport of photosensitizers: potential impact on photodynamic therapy.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Proliferation; Chlorophyll; Chlorophyllides; Flow Cytometry; Fluorescence; Humans; Indoles; Kidney; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Tumor Cells, Cultured | 2005 |
Specific intensity imaging for glioblastoma and neural cell cultures with 5-aminolevulinic acid-derived protoporphyrin IX.
Topics: Aminolevulinic Acid; Animals; Astrocytes; Cells, Cultured; Fluorescence; Glioblastoma; Humans; Neurons; Photosensitizing Agents; Protoporphyrins; Rats; Time Factors | 2005 |
The monitoring of the accumulation of protoporphyrin IX in Walker tumours by subcutaneous administration of delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Carcinoma 256, Walker; Injections, Subcutaneous; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Skin Neoplasms | 2004 |
Antifungal effect of 5-aminolevulinic acid PDT in Trichophyton rubrum.
Topics: Aminolevulinic Acid; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Mycelium; Onychomycosis; Photochemotherapy; Protoporphyrins; Trichophyton | 2005 |
Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization.
Topics: alpha-Tocopherol; Aminolevulinic Acid; Arachidonic Acid; Cell Line, Tumor; Cell Proliferation; Cell Survival; Docosahexaenoic Acids; Fatty Acids, Unsaturated; Humans; Malondialdehyde; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2005 |
RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid-induced protoporphyrin IX in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspases; Catalysis; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Membrane; Cluster Analysis; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genetic Techniques; Humans; Immediate-Early Proteins; In Vitro Techniques; Mitochondria; Models, Genetic; Models, Statistical; Necrosis; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phosphoprotein Phosphatases; Photochemotherapy; Photosensitizing Agents; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors; Up-Regulation | 2005 |
Reorganization of cytoskeleton induced by 5-aminolevulinic acid-mediated photodynamic therapy and its correlation with mitochondrial dysfunction.
Topics: Acid Phosphatase; Adenosine Triphosphate; Aminolevulinic Acid; Animals; Cell Adhesion; Cytoskeleton; Membrane Potentials; Mice; Microscopy, Electron, Transmission; Microscopy, Video; Mitochondria; NIH 3T3 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2005 |
Enhancement of the effect of 5-aminolevulinic acid-based photodynamic therapy by simultaneous hyperthermia.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Separation; Chaperonin 60; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; HSP70 Heat-Shock Proteins; Humans; Hyperthermia, Induced; Light; Membrane Potentials; Microscopy, Phase-Contrast; Mitochondria; Osteosarcoma; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors | 2005 |
Lipid cubic phases for improved topical drug delivery in photodynamic therapy.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Fluorescence; Glycerides; Lipids; Mice; Mice, Inbred BALB C; Photochemotherapy; Protoporphyrins | 2005 |
Topical glycerol monooleate/propylene glycol formulations enhance 5-aminolevulinic acid in vitro skin delivery and in vivo protophorphyrin IX accumulation in hairless mouse skin.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Chemistry, Pharmaceutical; Glycerides; In Vitro Techniques; Male; Mice; Mice, Hairless; Propylene Glycol; Protoporphyrins; Rats; Skin; Skin Absorption | 2005 |
Determination of intracellular prolyl/glycyl proteases in intact living human cells and protoporphyrin IX production as a reporter system.
Topics: Adenosine Deaminase; Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cysteine Endopeptidases; Dipeptidyl Peptidase 4; Drug Design; Female; Fluorescent Dyes; Glycoproteins; Humans; Kinetics; Male; Methods; Prolyl Oligopeptidases; Protease Inhibitors; Protoporphyrins; Serine Endopeptidases; Substrate Specificity | 2005 |
In vitro and ex vivo protoporphyrin IX expression induced by 5-aminolevulinic acid in human pilosebaceous unit.
Topics: Aminolevulinic Acid; Hair Follicle; Humans; Keratinocytes; Protoporphyrins; Sebaceous Glands | 2005 |
Photodynamic therapy of Walker tumors by multiple laser irradiation.
Topics: Aminolevulinic Acid; Animals; Carcinoma 256, Walker; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats | 2005 |
Correlation between macroscopic fluorescence and protoporphyrin IX content in psoriasis and actinic keratosis following application of aminolevulinic acid.
Topics: Aminolevulinic Acid; DNA; Humans; Keratosis; Protoporphyrins; Psoriasis; Spectrometry, Fluorescence | 2005 |
Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hyperoxia; Lipid Peroxidation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Urinary Bladder Neoplasms | 2005 |
Size and surface charge effect of 5-aminolevulinic acid-containing liposomes on photodynamic therapy for cultivated cancer cells.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Liposomes; Mice; Particle Size; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Surface Properties | 2005 |
Expression pattern and intensity of protoporphyrin IX induced by liposomal 5-aminolevulinic acid in rat pilosebaceous unit throughout hair cycle.
Topics: Aminolevulinic Acid; Animals; Hair Follicle; Hydrogen-Ion Concentration; Liposomes; Photochemotherapy; Protoporphyrins; Rats; Rats, Sprague-Dawley; Sebaceous Glands | 2005 |
Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation.
Topics: Aminolevulinic Acid; Animals; Breast Neoplasms; Mice; Mice, Transgenic; Neoplasm Metastasis; Protoporphyrins; Time Factors | 2005 |
Influence of light exposure on the kinetics of protoporphyrin IX formation in normal skin of hairless mice after application of 5-aminolevulinic acid methyl ester.
Topics: Aminolevulinic Acid; Animals; Kinetics; Light; Mice; Mice, Hairless; Protoporphyrins; Skin | 2005 |
Targeting PBR by hexaminolevulinate-mediated photodynamic therapy induces apoptosis through translocation of apoptosis-inducing factor in human leukemia cells.
Topics: Aminolevulinic Acid; Apoptosis; Apoptosis Inducing Factor; Cell Line, Tumor; Cell Nucleus; Cytochromes c; Humans; Intracellular Membranes; Leukemia, Lymphoid; Membrane Potentials; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Receptors, GABA; Subcellular Fractions | 2005 |
Photobleaching kinetics, photoproduct formation, and dose estimation during ALA induced PpIX PDT of MLL cells under well oxygenated and hypoxic conditions.
Topics: Aminolevulinic Acid; Animals; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Light; Oxygen; Photobleaching; Photosensitizing Agents; Protoporphyrins; Rats; Sensitivity and Specificity; Spectrometry, Fluorescence | 2006 |
The cytotoxic and genotoxic potential of 5-aminolevulinic acid on lymphocytes: a comet assay study.
Topics: Aged; Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; Humans; Lymphocytes; Male; Microscopy, Confocal; Mutagens; Nasopharyngeal Neoplasms; Photosensitizing Agents; Protoporphyrins; Ultraviolet Rays | 2006 |
In vitro percutaneous absorption and in vivo protoporphyrin IX accumulation in skin and tumors after topical 5-aminolevulinic acid application with enhancement using an erbium:YAG laser.
Topics: Administration, Cutaneous; Aluminum; Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Cell Line, Tumor; Erbium; Female; In Vitro Techniques; Lasers; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Absorption; Skin Neoplasms; Water Loss, Insensible; Yttrium | 2006 |
Regulation of porphyrin synthesis and photodynamic therapy in heavy metal intoxication.
Topics: Aminolevulinic Acid; Animals; Cell Cycle; Enzyme Inhibitors; Gallium; Humans; Hydroxymethylbilane Synthase; Lead; Neurons; PC12 Cells; Photochemotherapy; Photosensitizing Agents; Porphobilinogen Synthase; Proteasome Endopeptidase Complex; Protoporphyrins; Rats; RNA, Messenger | 2006 |
Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cytochromes c; DNA Fragmentation; Humans; Membrane Potentials; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2006 |
Spectroscopic measurements of photoinduced processes in human skin after topical application of the hexyl ester of 5-aminolevulinic acid.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Humans; Male; Oxyhemoglobins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Spectrum Analysis | 2006 |
Characteristics of 5-aminolaevulinic acid-induced protoporphyrin IX fluorescence in human skin in vivo.
Topics: Adult; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Middle Aged; Protoporphyrins; Reference Values; Skin | 2006 |
Fluorescence staining of human ovarian cancer tissue following application of 5-aminolevulinic acid: fluorescence microscopy studies.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Biopsy; Fallopian Tube Neoplasms; Female; Humans; Laparoscopy; Microscopy, Fluorescence; Ovarian Neoplasms; Photochemotherapy; Photosensitizing Agents; Predictive Value of Tests; Protoporphyrins; Second-Look Surgery; Sensitivity and Specificity | 2006 |
Integral spectrophotometric analysis of 5-aminolaevulinic acid-induced fluorescence cytology of the urinary bladder.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Female; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Therapeutic Irrigation; Urinary Bladder; Urinary Bladder Neoplasms | 2006 |
In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Delivery Systems; Epidermis; Humans; Membranes, Artificial; Ointments; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 2006 |
Griseofulvin enhances the effect of aminolevulinic acid-based photodynamic therapy in vitro.
Topics: Aminolevulinic Acid; Antifungal Agents; Griseofulvin; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2006 |
Subcellular localization pattern of protoporphyrin IX is an important determinant for its photodynamic efficiency of human carcinoma and normal cell lines.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Cell Survival; Esophageal Neoplasms; Humans; Membrane Potentials; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Subcellular Fractions | 2006 |
Influence of administration methods on the accumulation of ALA-induced Pp-IX in mouse tongue tumors.
Topics: Administration, Oral; Administration, Topical; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Statistics, Nonparametric; Tongue Neoplasms | 2006 |
Tumor cell lines resistant to ALA-mediated photodynamic therapy and possible tools to target surviving cells.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Light; Mice; Oxygen Consumption; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Pyrimidinones; Tetrazolium Salts; Thiazoles | 2006 |
Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells.
Topics: Aminolevulinic Acid; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coproporphyrinogen Oxidase; Humans; Male; Methotrexate; Metribolone; Models, Biological; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Up-Regulation | 2006 |
Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation.
Topics: Aminolevulinic Acid; Animals; Cattle; Deferoxamine; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heme; Iron; Models, Biological; Organ Culture Techniques; Oxidation-Reduction; Photosensitizing Agents; Protoporphyrins; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Serotonin; Soluble Guanylyl Cyclase; Vasodilation | 2006 |
Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study.
Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Biopsy; Cell Differentiation; Cell Proliferation; Epidermis; Female; Filaggrin Proteins; Fluorescence; Humans; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Skin; Skin Absorption; T-Lymphocyte Subsets | 2006 |
Fractionated illumination after topical application of 5-aminolevulinic acid on normal skin of hairless mice: the influence of the dark interval.
Topics: Aminolevulinic Acid; Animals; Fluorescence; Kinetics; Mice; Mice, Nude; Photobleaching; Photochemotherapy; Photoperiod; Photosensitizing Agents; Protoporphyrins | 2006 |
A study comparing endogenous protoporphyrin IX induced by 5-ALA and ALA-methyl ester with exogenous PpIX and PpIX dimethyl ester in photodynamic diagnosis of human nasopharyngeal carcinoma xenografts.
Topics: Aminolevulinic Acid; Animals; Carcinoma; Humans; Male; Mice; Mice, Inbred Strains; Nasopharyngeal Neoplasms; Photosensitizing Agents; Protoporphyrins; Up-Regulation; Xenograft Model Antitumor Assays | 2006 |
Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin.
Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Humans; Middle Aged; Photosensitizing Agents; Protoporphyrins; Skin; Skin Absorption; Spectrometry, Fluorescence | 2006 |
Involvement of both caspase-dependent and -independent pathways in apoptotic induction by hexaminolevulinate-mediated photodynamic therapy in human lymphoma cells.
Topics: Amino Acid Chloromethyl Ketones; Aminolevulinic Acid; Apoptosis; Apoptosis Inducing Factor; Caspases; Cytochromes c; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia, T-Cell; Membrane Potential, Mitochondrial; Mitochondria; Photochemotherapy; Protoporphyrins | 2006 |
Vitamin D enhances ALA-induced protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytes.
Topics: Aminolevulinic Acid; Animals; Biomarkers; Cell Death; Cell Differentiation; Cell Line; Dogs; Keratinocytes; Light; Organ Culture Techniques; Protoporphyrins; Rats; Time Factors; Vitamin D | 2007 |
Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach.
Topics: Aminolevulinic Acid; Animals; Cell Survival; In Vitro Techniques; Microscopy, Electron, Scanning; Mucous Membrane; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Soft Tissue Injuries; Spectrometry, Fluorescence; Swine; Urinary Bladder Neoplasms; Urothelium | 2007 |
[5-ALA fluorescence guided tumor resection].
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Middle Aged; Mitochondria; Neurosurgical Procedures; Photosensitizing Agents; Prognosis; Protoporphyrins | 2006 |
The role of nitric oxide in delta-aminolevulinic acid (ALA)-induced photosensitivity of cancerous cells.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Ferrochelatase; Humans; Interferon-gamma; Kidney; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Photosensitizing Agents; Protoporphyrins | 2007 |
Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; Flow Cytometry; Glioma; Humans; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction | 2007 |
Relation between intracellular location and photodynamic efficacy of 5-aminolevulinic acid-induced protoporphyrin IX in vitro. Comparison between human glioblastoma cells and other cancer cell lines.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Dose-Response Relationship, Radiation; Glioblastoma; Humans; Lasers; Photochemistry; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Structure-Activity Relationship; Tumor Cells, Cultured | 2007 |
Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug Therapy, Combination; Humans; Liver Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tissue Distribution; Treatment Outcome; Tumor Suppressor Protein p53 | 2007 |
Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas.
Topics: Aged; Aminolevulinic Acid; Astrocytoma; Brain Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2007 |
Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions.
Topics: Aminolevulinic Acid; Drug Stability; Esters; Hydrogen-Ion Concentration; Kinetics; Photochemotherapy; Protoporphyrins; Temperature | 2007 |
Photodynamic diagnosis (PDD) using 5-aminolevulinic acid-supplemented cultures of human endometrial epithelial cells.
Topics: Aminolevulinic Acid; Cells, Cultured; Endometriosis; Endometrium; Epithelial Cells; Estradiol; Female; Fluorescence; Humans; Microscopy, Confocal; Progesterone; Protoporphyrins; Time Factors | 2006 |
Endoscopic identification and biopsy sampling of an intraventricular malignant glioma using a 5-aminolevulinic acid-induced protoporphyrin IX fluorescence imaging system. Technical note.
Topics: Aminolevulinic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Female; Fluorescence; Humans; Middle Aged; Neuroendoscopy; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted | 2007 |
Detection of urinary bladder cancer with flow cytometry and hexaminolevulinate in urine samples.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biomarkers, Tumor; Carcinoma, Transitional Cell; Cell Line, Tumor; Cytodiagnosis; Feasibility Studies; Female; Flow Cytometry; Humans; Male; Middle Aged; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity; Urinalysis; Urinary Bladder Neoplasms; Urine; Urothelium | 2007 |
Photodetection of basal cell carcinoma using methyl 5-aminolaevulinate-induced protoporphyrin IX based on fluorescence image analysis.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Facial Neoplasms; Female; Humans; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence | 2007 |
Two-photon photodynamic therapy of C6 cells by means of 5-aminolevulinic acid induced protoporphyrin IX.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Radiation; Glioma; Light; Photochemotherapy; Photons; Protoporphyrins; Rats | 2007 |
Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Feasibility Studies; Glioma; Humans; Magnetic Resonance Imaging; Middle Aged; Monte Carlo Method; Neoplasm Recurrence, Local; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Radiosurgery | 2007 |
Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Mice; Molecular Structure; Peptides; Permeability; Photochemotherapy; Prodrugs; Protoporphyrins; Time Factors | 2007 |
Parasiticidal effect of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells.
Topics: Aminolevulinic Acid; Animals; Cell Line, Transformed; Disease Models, Animal; Ear, External; Interleukin-6; Leishmania major; Leishmaniasis, Cutaneous; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2007 |
Increase in protoporphyrin IX after 5-aminolevulinic acid based photodynamic therapy is due to local re-synthesis.
Topics: Aminolevulinic Acid; Animals; Arterioles; Female; Fluorescence; Kinetics; Photochemotherapy; Protoporphyrins; Rats; Rats, Inbred F344; Temperature; Venules | 2007 |
Fluorescence diagnosis in keratinocytic intraepidermal neoplasias.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Proliferation; Diagnosis, Computer-Assisted; Diagnosis, Differential; Epidermis; Female; Fluorescence; Humans; Immunohistochemistry; Keratinocytes; Ki-67 Antigen; Male; Middle Aged; Neoplasm Staging; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 2007 |
5-aminolevulinic acid-mediated photodynamic therapy on Hep-2 and MCF-7c3 cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Deferoxamine; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Light; Liver Neoplasms; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2007 |
Cell-substrate topology upon ALA-PDT using variable-angle total internal reflection fluorescence microscopy (VA-TIRFM).
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Drug Screening Assays, Antitumor; Female; Glioblastoma; HeLa Cells; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2007 |
Biochemical manipulation via iron chelation to enhance porphyrin production from porphyrin precursors.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Esters; Fibroblasts; Fluorescence; Humans; Iron Chelating Agents; Lung; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Pyridones | 2007 |
5-Aminolevulinic acid-induced protoporphyrin-IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines.
Topics: Aminolevulinic Acid; Animals; Biological Assay; Carcinoma, Transitional Cell; Cell Line, Tumor; Humans; Macrophages, Peritoneal; Male; Mice; Microscopy, Fluorescence; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Propidium; Protoporphyrins | 2007 |
Comparison of aminolevulinic acid- and hexylester aminolevulinate-induced protoporphyrin IX fluorescence for the detection of ovarian cancer in a rat model.
Topics: Aminolevulinic Acid; Animals; Female; Laparoscopy; Microscopy, Fluorescence; Ovarian Neoplasms; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Spectrometry, Fluorescence; Statistics, Nonparametric | 2007 |
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Humans; Protoporphyrins; RNA, Messenger; RNA, Small Interfering; Stomach Neoplasms | 2008 |
Sufficient PpIX production for PDT even with short contact time of topically applied 5-ALA in rabbit tongues.
Topics: Aminolevulinic Acid; Animals; Epithelium; Male; Models, Animal; Mouth Mucosa; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rabbits; Time Factors; Tongue | 2008 |
Sensitivity of osteoblasts, fibroblasts, bone marrow cells, and dendritic cells to 5-aminolevulinic acid based photodynamic therapy.
Topics: Alkaline Phosphatase; Aminolevulinic Acid; Animals; Bone Marrow Cells; Cell Survival; Dendritic Cells; Fibroblasts; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Osteoblasts; Photochemotherapy; Protoporphyrins | 2007 |
Fluorescence characteristics and pharmacokinetic properties of a novel self-adhesive 5-ALA patch for photodynamic therapy of actinic keratoses.
Topics: Adhesives; Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Case-Control Studies; Dosage Forms; Dose-Response Relationship, Drug; Environmental Exposure; Female; Fluorescence; Humans; Keratosis; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Prospective Studies; Protoporphyrins; Time Factors; Ultraviolet Rays | 2008 |
Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Enzyme Inhibitors; Heme Oxygenase-1; Humans; Melanoma; Metalloporphyrins; Photochemotherapy; Protoporphyrins; RNA, Small Interfering | 2007 |
Analyzing effects of photodynamic therapy with 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PPIX) in urothelial cells using reverse phase protein arrays.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Radiation; Gene Expression Profiling; Humans; Photochemotherapy; Protein Array Analysis; Protoporphyrins; Signal Transduction; Urothelium | 2007 |
Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study.
Topics: Aminolevulinic Acid; Brain Neoplasms; Humans; Microscopy, Fluorescence; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins | 2007 |
The C-terminal extension of ferrochelatase is critical for enzyme activity and for functioning of the tetrapyrrole pathway in Synechocystis strain PCC 6803.
Topics: Aminolevulinic Acid; Bacterial Proteins; Blotting, Western; Ferrochelatase; Immunoblotting; Models, Biological; Mutation; Protoporphyrins; Recombinant Proteins; Synechocystis; Tetrapyrroles | 2008 |
Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Chemistry, Pharmaceutical; Drug Stability; Drug Storage; Ethanol; Female; Liposomes; Mice; Mice, Inbred ICR; Mice, Nude; Particle Size; Permeability; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Absorption; Skin Neoplasms; Surface-Active Agents | 2008 |
Glycoside esters of 5-aminolevulinic acid for photodynamic therapy of cancer.
Topics: Aminolevulinic Acid; Cell Line; Cell Line, Tumor; Cell Proliferation; Endothelial Cells; Esterases; Esterification; Fibroblasts; Glycoside Hydrolases; Glycosides; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Sensitivity and Specificity | 2008 |
Kinetics and subcellular localization of 5-ALA-induced PpIX in DHL cells via two-photon excitation fluorescence microscopy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Humans; Lymphoma, Follicular; Microscopy, Fluorescence; Photochemotherapy; Protoporphyrins | 2008 |
5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institutuion.
Topics: Aminolevulinic Acid; Biopsy; Fluorescence; Glioma; Humans; Prognosis; Protoporphyrins; Sensitivity and Specificity | 2008 |
A HCl/alcohol formulation increased 5-aminolevulinic acid skin distribution using an ex vivo full thickness porcine skin model.
Topics: Alcohols; Aminolevulinic Acid; Animals; Female; Hydrochloric Acid; Microscopy, Fluorescence; Models, Animal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Surgical Tape; Sus scrofa | 2008 |
Selective accumulation of PpIX and photodynamic effect after aminolevulinic acid treatment of human adenomyosis xenografts in nude mice.
Topics: Adult; Aminolevulinic Acid; Animals; Endometriosis; Female; Humans; Injections, Intraperitoneal; Japan; Mice; Mice, Nude; Middle Aged; Photochemotherapy; Protoporphyrins; Transplantation, Heterologous | 2008 |
Relationship of protoporphyrin IX synthesis to photodynamic effects by 5-aminolaevulinic acid and its esters on various cell lines derived from the skin.
Topics: Aminolevulinic Acid; Cell Death; Cell Line; Dose-Response Relationship, Drug; Esters; Flow Cytometry; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Tumor Cells, Cultured | 2008 |
Protoporphyrin IX fluorescence photobleaching is a useful tool to predict the response of rat ovarian cancer following hexaminolevulinate photodynamic therapy.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Female; Microscopy, Fluorescence; Ovarian Neoplasms; Photobleaching; Photochemotherapy; Photosensitizing Agents; Predictive Value of Tests; Protoporphyrins; Rats; Rats, Inbred F344; Reproducibility of Results | 2008 |
5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Cell Death; Cell Line; Endocytosis; Esterases; Female; Fluorescein; Fluorescence; In Vitro Techniques; Kinetics; Mice; Peptides; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Skin; Swine | 2008 |
Microscopic localisation of protoporphyrin IX in normal mouse skin after topical application of 5-aminolevulinic acid or methyl 5-aminolevulinate.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Mice; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Skin | 2008 |
Regulation of 5-aminolevulinic acid-dependent protoporphyrin IX accumulations in human histiocytic lymphoma U937 cells.
Topics: Aminolevulinic Acid; Chlorides; Deferoxamine; Humans; Lymphoma, Large B-Cell, Diffuse; Manganese Compounds; Mesoporphyrins; Protoporphyrins; U937 Cells | 2007 |
Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 2008 |
In vivo mitochondrial oxygen tension measured by a delayed fluorescence lifetime technique.
Topics: Aminolevulinic Acid; Animals; Calibration; Cell Separation; Hepatocytes; Injections, Intravenous; Liver; Male; Microscopy, Fluorescence; Mitochondria, Liver; Oxygen; Partial Pressure; Protoporphyrins; Rats; Rats, Wistar; Reperfusion Injury; Time Factors | 2008 |
Analysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Microscopy, Electron, Transmission; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 2008 |
Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzothiazoles; Blotting, Western; Cell Line, Tumor; Chlorophyll; Chromatography, High Pressure Liquid; Diamines; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Heme Oxygenase-1; Humans; Neoplasm Proteins; Neoplasms; NF-E2-Related Factor 2; Organic Chemicals; Oxidative Stress; Photochemistry; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Quinolines; RNA, Messenger; RNA, Small Interfering; Transfection | 2008 |
Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Stability; Humans; Isothiocyanates; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Sulfoxides; Thiocyanates | 2008 |
Effects of PDT with 5-aminolevulinic acid and chitosan on Walker carcinosarcoma.
Topics: Aminolevulinic Acid; Animals; Anticholesteremic Agents; Carcinosarcoma; Chitosan; Combined Modality Therapy; Drug Therapy, Combination; Light; Lipid Peroxidation; Male; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar | 2008 |
Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Dose-Response Relationship, Drug; Female; Humans; Male; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Time Factors | 2008 |
Microscopic distribution of protoporphyrin (PpIX) fluorescence in superficial basal cell carcinoma during light-fractionated aminolaevulinic acid photodynamic therapy.
Topics: Aminolevulinic Acid; Biopsy; Carcinoma, Basal Cell; Humans; Immunohistochemistry; Ki-67 Antigen; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms | 2008 |
Etretinate enhances the susceptibility of human skin squamous cell carcinoma cells to 5-aminolaevulic acid-based photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Death; Dose-Response Relationship, Drug; Drug Evaluation; Drug Synergism; Etretinate; Humans; Keratolytic Agents; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Tumor Cells, Cultured | 2009 |
Sustained and efficient porphyrin generation in vivo using dendrimer conjugates of 5-ALA for photodynamic therapy.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Coloring Agents; Dendrimers; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Molecular Structure; Molecular Weight; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Time Factors; Xenograft Model Antitumor Assays | 2009 |
Induction of protoporphyrin IX by aminolaevulinic acid in actinic keratosis, psoriasis and normal skin: preferential porphyrin enrichment in differentiated cells.
Topics: Administration, Topical; Aminolevulinic Acid; Humans; Keratosis, Actinic; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Psoriasis; Skin Absorption; Spectrometry, Fluorescence | 2009 |
Influence of formulation factors on PpIX production and photodynamic action of novel ALA-loaded microparticles.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Female; Gels; Mice; Mice, Inbred BALB C; Mice, Nude; Microspheres; Neoplasms, Experimental; Photochemotherapy; Photosensitizing Agents; Propylene Glycol; Protoporphyrins; Skin Neoplasms | 2009 |
Mitochondrial oxygen tension within the heart.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Flow Cytometry; Heart; Male; Microscopy, Fluorescence; Mitochondria, Heart; Oxygen Consumption; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar | 2009 |
Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism.
Topics: Aminolevulinic Acid; Animals; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Gene Knockdown Techniques; Intracellular Space; Mice; Models, Biological; Peptide Hydrolases; Peptides; Prodrugs; Protoporphyrins; RNA Interference; RNA, Small Interfering | 2009 |
Treatment of perianal Paget's disease using photodynamic therapy with assistance of fluorescence examination: case report.
Topics: Aged; Aminolevulinic Acid; Anus Neoplasms; Female; Fluorescence; Humans; Laser Therapy; Paget Disease, Extramammary; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2009 |
[Two-photon excitation fluorescence of 5-ALA induced PpIX in DHL cells].
Topics: Aminolevulinic Acid; Cell Line, Tumor; Gene Expression; Humans; Kinetics; Microscopy, Confocal; Microscopy, Fluorescence; Photons; Protoporphyrins | 2008 |
Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells.
Topics: Aminolevulinic Acid; Calcitriol; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Stem Cell Assay | 2009 |
Hypericin and 5-aminolevulinic acid-induced protoporphyrin IX induce enhanced phototoxicity in human endometrial cancer cells with non-coherent white light.
Topics: Aminolevulinic Acid; Anthracenes; Apoptosis; Cell Line, Tumor; Drug Synergism; Endometrial Neoplasms; Female; Humans; Light; Perylene; Photosensitizing Agents; Protoporphyrins | 2009 |
Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coproporphyrinogen Oxidase; Dose-Response Relationship, Drug; Ferrochelatase; Filaggrin Proteins; Humans; Keratinocytes; Light; Methotrexate; Mice; Mice, Nude; Neoplasms, Experimental; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Xenograft Model Antitumor Assays | 2009 |
A comparison of 5-aminolaevulinic acid- and its heptyl ester: dark cytotoxicity and protoporphyrin IX synthesis in human adenocarcinoma WiDr cells and in athymic nude mice healthy skin.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Skin; Skin Neoplasms; Spectrometry, Fluorescence | 2009 |
Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization.
Topics: Aminolevulinic Acid; Animals; Cell Line; Dipeptides; Humans; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Structure-Activity Relationship | 2009 |
Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Kaplan-Meier Estimate; Mice; Mice, Inbred Strains; Papilloma; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: inhibitory effects of nitric oxide.
Topics: Aminolevulinic Acid; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cytoprotection; Female; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2009 |
Parallel pigment and transcriptomic analysis of four barley albina and xantha mutants reveals the complex network of the chloroplast-dependent metabolism.
Topics: Aminolevulinic Acid; Chloroplasts; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Plant; Hordeum; Lyases; Plant Proteins; Protein Subunits; Protoporphyrins; RNA, Messenger; Transcription, Genetic | 2009 |
Precise detection of lymph node metastases in mouse rectal cancer by using 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Female; Green Fluorescent Proteins; Humans; Lymph Nodes; Lymphatic Metastasis; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Photosensitizing Agents; Protoporphyrins; Rectal Neoplasms; Tumor Cells, Cultured | 2009 |
Porphyrin synthesis from aminolevulinic acid esters in endothelial cells and its role in photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Cell Line; Endothelial Cells; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Ultraviolet Rays | 2009 |
Endogenous and exogenous porphyrins as photosensitizers in the Hep-2 human carcinoma cell line.
Topics: Aminolevulinic Acid; Carcinoma; Cell Line, Tumor; Cell Survival; Fullerenes; Humans; Laryngeal Neoplasms; Light; Liposomes; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins | 2009 |
Ros production by endogenously generated Protoporphyrin IX in murine leukemia cells.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Leukemia; Membrane Potential, Mitochondrial; Mice; Mitochondria; Photochemotherapy; Protoporphyrins; Reactive Oxygen Species; Superoxides; Ultraviolet Rays | 2009 |
Topical delivery of 5-aminolevulinic acid-encapsulated ethosomes in a hyperproliferative skin animal model using the CLSM technique to evaluate the penetration behavior.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Female; Liposomes; Mice; Mice, Inbred ICR; Mice, Nude; Microscopy, Confocal; Permeability; Phosphatidylethanolamines; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Psoriasis; Skin Absorption; Tumor Necrosis Factor-alpha | 2009 |
Desferrioxamine shows different potentials for enhancing 5-aminolaevulinic acid-based photodynamic therapy in several cutaneous cell lines.
Topics: Aminolevulinic Acid; Cell Death; Cell Line; Deferoxamine; Drug Synergism; Fibroblasts; Humans; Iron Chelating Agents; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Diseases | 2010 |
5-ALA derivative-mediated photoinactivation of Propionibacterium acnes.
Topics: Aminolevulinic Acid; Gram-Positive Bacterial Infections; Humans; Light; Photochemotherapy; Propionibacterium acnes; Protoporphyrins | 2009 |
Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937.
Topics: Aminolevulinic Acid; Apoptosis; Enzyme Inhibitors; Ferrochelatase; Humans; Light; Lymphoma, Large B-Cell, Diffuse; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; U937 Cells | 2009 |
Topical aminolaevulinic acid- and aminolaevulinic acid methyl ester-based photodynamic therapy with red and violet light: influence of wavelength on pain and erythema.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Animals; Erythema; Humans; Lasers; Mice; Mice, Nude; Middle Aged; Pain; Pain Measurement; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors | 2009 |
Photochemically induced increase in endothelial permeability regulated by RhoA activation.
Topics: Actins; Aminolevulinic Acid; Antigens, CD; Cadherins; Endothelial Cells; Enzyme Activation; Humans; Intracellular Space; Light; Permeability; Photochemical Processes; Photochemotherapy; Prodrugs; Protoporphyrins; rhoA GTP-Binding Protein | 2009 |
Silencing of ALA dehydratase affects ALA-photodynamic therapy efficacy in K562 erythroleukemic cells.
Topics: Aminolevulinic Acid; Cell Death; Gene Silencing; Humans; K562 Cells; Leukemia, Erythroblastic, Acute; Mitochondria; Photochemotherapy; Porphobilinogen Synthase; Protoporphyrins | 2009 |
Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDT.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Models, Cardiovascular; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Regional Blood Flow; Skin Neoplasms; Spectrometry, Fluorescence | 2009 |
The effects of keratolytic pretreatment prior to fluorescence diagnosis and photodynamic therapy with aminolevulinic acid-induced porphyrins in psoriasis.
Topics: Administration, Topical; Aged; Aminolevulinic Acid; Analysis of Variance; Bandages, Hydrocolloid; Biopsy, Needle; Female; Fluorescence; Humans; Immunohistochemistry; Keratolytic Agents; Male; Middle Aged; Photochemotherapy; Pilot Projects; Probability; Protoporphyrins; Psoriasis; Skin Absorption; Treatment Outcome; Tretinoin | 2010 |
Fluorescence induction of protoporphyrin IX by a new 5-aminolevulinic acid nanoemulsion used for photodynamic therapy in a full-thickness ex vivo skin model.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Emulsions; Fluorescence; Models, Animal; Photochemotherapy; Protoporphyrins; Skin; Skin Absorption; Swine | 2010 |
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target.
Topics: Aminolevulinic Acid; Anti-Infective Agents; Antineoplastic Agents; Artemisinins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Heme; Humans; Iron; Models, Chemical; Protoporphyrins; Spectrophotometry; Transferrin | 2009 |
Synergistic increase in osteosarcoma cell sensitivity to photodynamic therapy with aminolevulinic acid hexyl ester in the presence of hyperthermia.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Combined Modality Therapy; Humans; Hyperthermia, Induced; Infrared Rays; Mandibular Neoplasms; Osteosarcoma; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2009 |
Heating increases protoporphyrin IX production in normal skin after delivery of 5-aminolevulinic acid by iontophoresis.
Topics: Adult; Aminolevulinic Acid; Hot Temperature; Humans; Iontophoresis; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms | 2009 |
Anticancer effect of photodynamic therapy with hexenyl ester of 5-aminolevulinic acid in oral squamous cell carcinoma.
Topics: Aminolevulinic Acid; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; Cell Death; Cell Survival; Flow Cytometry; Humans; Mouth Neoplasms; Photochemotherapy; Protoporphyrins; Reactive Oxygen Species; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2010 |
Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX accumulation in human urothelial carcinomas.
Topics: Aminolevulinic Acid; beta-Alanine; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carcinoma, Transitional Cell; Cell Line, Tumor; Deferoxamine; Ferrochelatase; Flow Cytometry; Humans; Microscopy, Fluorescence; Mitochondria; Nitroso Compounds; Oxidative Phosphorylation; Photosensitizing Agents; Protoporphyrins; Time Factors; Urinary Bladder Neoplasms; Urothelium | 2009 |
Intralesional photodynamic therapy: a comment on 'Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy' by Gerritsen et al.
Topics: Aminolevulinic Acid; Humans; Injections, Intralesional; Photochemotherapy; Protoporphyrins; Skin Neoplasms | 2010 |
A comparative study on the enhancement efficacy of specific and non-specific iron chelators for protoporphyrin IX production and photosensitization in HaCat cells.
Topics: Aminolevulinic Acid; Cell Line, Transformed; Deferoxamine; Edetic Acid; Humans; Iron Chelating Agents; Keratinocytes; Photosensitivity Disorders; Photosensitizing Agents; Protoporphyrins | 2009 |
Hexaminolevulinate-mediated photodynamic purging of leukemia cells from BM.
Topics: Aminolevulinic Acid; Animals; Bone Marrow Cells; Bone Marrow Purging; Bone Marrow Transplantation; Cell Line, Tumor; Cell Survival; Female; Gamma Rays; Granulocytes; Leukemia L1210; Mice; Mice, Inbred DBA; Osmolar Concentration; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Survival Analysis; Tumor Stem Cell Assay; Whole-Body Irradiation | 2010 |
[Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chi-Square Distribution; Esters; Female; Fluorescence; Follow-Up Studies; Head and Neck Neoplasms; Humans; Male; Middle Aged; Photosensitizing Agents; Precancerous Conditions; Prognosis; Protoporphyrins; Sensitivity and Specificity; Skin; Skin Neoplasms | 2009 |
Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells.
Topics: Aminolevulinic Acid; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Chitosan; Colorectal Neoplasms; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Nanoparticles; Protoporphyrins; Receptors, Cell Surface | 2010 |
Fractional laser as a tool to enhance the skin permeation of 5-aminolevulinic acid with minimal skin disruption: a comparison with conventional erbium:YAG laser.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; Fluorescence; Lasers; Lasers, Solid-State; Light; Mice; Mice, Nude; Microscopy, Confocal; Protoporphyrins; Skin; Skin Absorption; Specific Pathogen-Free Organisms; Swine | 2010 |
Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Data Interpretation, Statistical; Female; Fluorescence; Glioma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Microscopy, Fluorescence; Middle Aged; Neurosurgical Procedures; Paraffin Embedding; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted | 2011 |
The influence of temperature on 5-aminolevulinic acid-based photodynamic reaction in keratinocytes in vitro.
Topics: Aminolevulinic Acid; Cell Death; Cell Line; Cytokines; Hot Temperature; Humans; Keratinocytes; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2010 |
Photodynamic therapy with intradermal administration of 5-aminolevulinic acid for port-wine stains.
Topics: Aminolevulinic Acid; Animals; Chickens; Disease Models, Animal; Female; Injections, Intradermal; Injections, Intravenous; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Port-Wine Stain; Probability; Protoporphyrins; Random Allocation; Skin Absorption | 2010 |
Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT.
Topics: Aged; Aminolevulinic Acid; Dose-Response Relationship, Drug; Fluorescence; Humans; Keratosis, Actinic; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Skin; Skin Neoplasms | 2010 |
Demonstration of protoporphyrin IX (PpIX) localized to areas of palmar skin injected with 5-aminolevulinic acid (ALA) and pre-treated with a fractionated CO2 laser prior to topically applied ALA.
Topics: Administration, Topical; Aminolevulinic Acid; Humans; Iontophoresis; Lasers, Gas; Photosensitizing Agents; Protoporphyrins; Skin | 2010 |
Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder.
Topics: Aminolevulinic Acid; Animals; Anthracenes; Antineoplastic Agents; Female; Fluorescence; Perylene; Photochemotherapy; Povidone; Protoporphyrins; Rats; Rats, Inbred F344; Solubility; Tissue Distribution; Urinary Bladder Neoplasms | 2011 |
Factors influencing pain intensity during topical photodynamic therapy of complete cosmetic units for actinic keratoses.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cosmetic Techniques; Female; Humans; Keratosis, Actinic; Male; Middle Aged; Nerve Endings; Pain; Pain Measurement; Photochemotherapy; Protoporphyrins; Retrospective Studies; Sex Characteristics; Treatment Outcome | 2010 |
Metronomic PDT and cell death pathways.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Electrophoresis; Humans; Intracellular Space; Oligonucleotide Array Sequence Analysis; Photochemotherapy; Polymerase Chain Reaction; Protoporphyrins; Rats; Receptors, Tumor Necrosis Factor; Reproducibility of Results | 2010 |
Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivo.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Female; Humans; Mice; Optical Fibers; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence | 2010 |
A case of Bowen's disease successfully treated by photodynamic therapy.
Topics: Aminolevulinic Acid; Bowen's Disease; Female; Humans; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Treatment Outcome | 2010 |
Penetration enhancement of two topical 5-aminolaevulinic acid formulations for photodynamic therapy by erbium:YAG laser ablation of the stratum corneum: continuous versus fractional ablation.
Topics: Aminolevulinic Acid; Animals; Epidermis; Feasibility Studies; Female; Lasers, Solid-State; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Swine | 2010 |
Improving intraoperative visualization of anaplastic foci within gliomas.
Topics: Aminolevulinic Acid; Biopsy; Brain Neoplasms; Carcinoma; Fluorescence; Glioma; Humans; Protoporphyrins; Radiosurgery | 2010 |
Effect and mechanism of 5-aminolevulinic acid-mediated photodynamic therapy in esophageal cancer.
Topics: Aminolevulinic Acid; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Female; Genes, bcl-2; Humans; Lasers; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; RNA, Messenger; RNA, Neoplasm | 2011 |
The role of nitric oxide in the treatment of tumours with aminolaevulinic acid-induced photodynamic therapy.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cell Line, Tumor; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitroarginine; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2010 |
Reduction of cutaneous photosensitivity by application of ointment containing ferrous or cobaltous ions concomitant with the use of topical protoporphyrin IX precursors.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Cobalt; Female; Ferrous Compounds; Mice; Mice, Inbred BALB C; Photosensitivity Disorders; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Zinc Sulfate | 2010 |
In vivo temporal evolution of ALA-induced normalized fluorescence at different anatomical locations of oral cavity: application to improve cancer diagnostic contrast and potential.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosis, Oral; Humans; Mouth; Mouth Diseases; Mouth Mucosa; Mouth Neoplasms; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence; Time Factors | 2010 |
The efficacy of photodynamic diagnosis in defining the lateral border between a tumor and a tumor-free area during Mohs micrographic surgery.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorescence; Humans; Male; Middle Aged; Mohs Surgery; Neoplasm Staging; Photosensitizing Agents; Protoporphyrins; Retrospective Studies; Skin Neoplasms | 2010 |
Detection and photodynamic therapy of inflamed atherosclerotic plaques in the carotid artery of rabbits.
Topics: Aminolevulinic Acid; Animals; Carotid Arteries; Inflammation; Macrophages; Male; Phagocytosis; Photochemotherapy; Plaque, Atherosclerotic; Protoporphyrins; Rabbits; Spectrometry, Fluorescence | 2011 |
Two-photon irradiation of an intracellular singlet oxygen photosensitizer: achieving localized sub-cellular excitation in spatially-resolved experiments.
Topics: Aminolevulinic Acid; Apoptosis; Cell Adhesion; Cell Line, Tumor; Humans; Lasers; Microscopy, Fluorescence; Mitochondria; Photons; Photosensitizing Agents; Protoporphyrins; Single-Cell Analysis; Singlet Oxygen | 2010 |
Quinolone compounds enhance delta-aminolevulinic acid-induced accumulation of protoporphyrin IX and photosensitivity of tumour cells.
Topics: Aminolevulinic Acid; Drug Synergism; Female; Ferric Compounds; Fluoroquinolones; HeLa Cells; Heme Oxygenase (Decyclizing); Hemin; Humans; Iron; Light; Metalloporphyrins; Nitrilotriacetic Acid; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Skin Neoplasms | 2011 |
Hexaminolevulinate-mediated photodynamic purging of marrow grafts with murine breast carcinoma.
Topics: Aminolevulinic Acid; Animals; Bone Marrow; Bone Marrow Purging; Cell Line, Tumor; Female; Hematopoietic Stem Cell Transplantation; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tumor Cells, Cultured | 2011 |
Determination of time-dependent protoporphyrin IX concentration for photodynamic therapy dosimetry in a mice colon tumor model using fluorescence spectroscopy.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Female; Kinetics; Male; Mice; Mice, Inbred BALB C; Photochemotherapy; Protoporphyrins; Spectrometry, Fluorescence | 2010 |
Evaluation of photodynamic therapy (PDT) procedures using microfluidic system.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Dimethylpolysiloxanes; Humans; Lab-On-A-Chip Devices; Lung Neoplasms; Microfluidic Analytical Techniques; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2011 |
Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Magnetic Resonance Angiography; Male; Methylation; Middle Aged; Neuronavigation; Polymerase Chain Reaction; Protoporphyrins; Spectrometry, Fluorescence; Tumor Suppressor Proteins | 2011 |
Precise comparison of protoporphyrin IX fluorescence spectra with pathological results for brain tumor tissue identification.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Spectrum Analysis | 2011 |
Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Ferrochelatase; Fluorescence; Gene Silencing; Glioma; Humans; Photochemotherapy; Protoporphyrins | 2011 |
Enhancement of blood porphyrin emission intensity with aminolevulinic acid administration: a new concept for photodynamic diagnosis of early prostate cancer.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cell Line, Tumor; Drug Synergism; Drug Therapy, Combination; Early Diagnosis; Image Enhancement; Male; Mice; Mice, Nude; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Radiation Tolerance; Sensitivity and Specificity | 2011 |
Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Drug Combinations; Female; Humans; Male; Metabolic Clearance Rate; Microscopy, Fluorescence; Middle Aged; Organ Specificity; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Spectrometry, Fluorescence; Tissue Distribution; Treatment Outcome | 2011 |
Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes.
Topics: Acne Vulgaris; Aminolevulinic Acid; Anti-Bacterial Agents; Coproporphyrins; Gram-Positive Bacterial Infections; Humans; In Vitro Techniques; Photochemotherapy; Photosensitizing Agents; Propionibacterium acnes; Protoporphyrins | 2011 |
5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor.
Topics: Aminolevulinic Acid; Animals; Carcinoma; Cell Line, Tumor; Fluorescence; Humans; Lung Neoplasms; Mesothelioma; Mice; Mice, SCID; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasms, Experimental; Photosensitizing Agents; Pleural Neoplasms; Protoporphyrins; Sensitivity and Specificity; Tumor Burden | 2011 |
Intense pulse light and 5-ALA PDT: phototoxic effects in vitro depend on the spectral overlap with protoporphyrine IX but do not match cut-off filter notations.
Topics: Aminolevulinic Acid; Cell Survival; Clinical Protocols; Dose-Response Relationship, Radiation; Humans; In Vitro Techniques; Keratinocytes; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrum Analysis | 2011 |
Measuring versus seeing.
Topics: Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Fluorescence; Humans; Magnetic Resonance Imaging; Photosensitizing Agents; Protoporphyrins | 2011 |
Simulation of fractionated and continuous irradiation in photodynamic therapy: study the differences between photobleaching and singlet oxygen dose deposition.
Topics: Aminolevulinic Acid; Animals; Colonic Neoplasms; Computer Simulation; Mice; Mice, Inbred BALB C; Models, Biological; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen; Spectrometry, Fluorescence | 2011 |
Drug delivery technologies and immunological aspects of photodynamic therapy.
Topics: Aminolevulinic Acid; Drug Carriers; Humans; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2011 |
An investigation of the fluorescence induced by topical application of 5-aminolaevulinic acid and methyl aminolaevulinate at different body sites on normal human skin.
Topics: Administration, Cutaneous; Adult; Aminolevulinic Acid; Back; Female; Fluorescence; Forearm; Humans; Leg; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2011 |
Isolation and characterization of squamous carcinoma cells resistant to photodynamic therapy.
Topics: Aminolevulinic Acid; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Nucleus Shape; Cell Shape; Cell Survival; Cytoskeletal Proteins; Drug Resistance, Neoplasm; Humans; Inhibitor of Apoptosis Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Ubiquitin-Protein Ligases | 2011 |
Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways.
Topics: Aminolevulinic Acid; Cell Death; Cell Line, Tumor; Glioblastoma; Humans; Hydroxymethylbilane Synthase; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Photochemotherapy; Prodrugs; Protoporphyrins; Reactive Oxygen Species | 2012 |
Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Humans; Models, Biological; Monte Carlo Method; Phantoms, Imaging; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen; Skin Neoplasms; Spectrometry, Fluorescence | 2011 |
Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas.
Topics: Aminolevulinic Acid; Diagnostic Imaging; Female; Humans; Meningeal Neoplasms; Meningioma; Middle Aged; Photosensitizing Agents; Protoporphyrins; Skull Base Neoplasms | 2011 |
The centrality of PBGD expression levels on ALA-PDT efficacy.
Topics: Aminolevulinic Acid; Apoptosis; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylbilane Synthase; K562 Cells; Leukemia, Erythroblastic, Acute; Light; Photochemotherapy; Porphobilinogen Synthase; Protoporphyrins; RNA Interference; RNA, Small Interfering | 2011 |
Targeting of sebaceous glands by δ-aminolevulinic acid-based photodynamic therapy: An in vivo study.
Topics: Acne Vulgaris; Aminolevulinic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sebaceous Glands; Skin; Spectrometry, Fluorescence | 2011 |
Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cattle; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Space; Ferrochelatase; Gene Expression Regulation; Gene Knockdown Techniques; Heme; Humans; Indoles; Neoplasm Proteins; Nitroso Compounds; Protoporphyrins; Serum; Serum Albumin, Bovine | 2011 |
Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells.
Topics: Aminolevulinic Acid; Annexin A5; Apoptosis; Cell Line, Tumor; Cholangiocarcinoma; Flow Cytometry; Humans; Necrosis; Photochemotherapy; Photomicrography; Photosensitizing Agents; Propidium; Protoporphyrins; Reactive Oxygen Species | 2011 |
Oxygen-dependent delayed fluorescence measured in skin after topical application of 5-aminolevulinic acid.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Fluorescence; Male; Oxygen; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Skin; Skin Neoplasms; Spectrometry, Fluorescence; Time Factors | 2011 |
Retained topical delivery of 5-aminolevulinic acid using cationic ultradeformable liposomes for photodynamic therapy.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Cations; Drug Compounding; Drug Stability; In Vitro Techniques; Liposomes; Male; Mice; Mice, Hairless; Particle Size; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Absorption; Skin Diseases; Surface Properties | 2011 |
Fluorescence illuminates the way ...
Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Male; Monitoring, Intraoperative; Protoporphyrins | 2011 |
δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Diagnostic Imaging; Female; Fluorescence; Fluorometry; Glioma; Humans; Immunoenzyme Techniques; Male; Microscopy, Fluorescence; Middle Aged; Monitoring, Intraoperative; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Young Adult | 2011 |
Comparative study of protoporphyrin IX fluorescence image enhancement methods to improve an optical imaging system for oral cancer detection.
Topics: Aminolevulinic Acid; Diagnostic Imaging; Fluorescence; Humans; Image Enhancement; Mouth Neoplasms; Optical Phenomena; Photosensitizing Agents; Protoporphyrins | 2011 |
¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Carbon Radioisotopes; Cell Count; Cell Proliferation; Female; Fluorescence; Glioma; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Positron-Emission Tomography; Protoporphyrins; Regression Analysis | 2012 |
Photodynamic therapy (PDT) - Initiation of apoptosis via activation of stress-activated p38 MAPK and JNK signal pathway in H460 cell lines.
Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Coloring Agents; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Signal Transduction; Tetrazolium Salts; Thiazoles; Up-Regulation | 2011 |
Photobleaching-based method to individualize irradiation time during interstitial 5-aminolevulinic acid photodynamic therapy.
Topics: Absorption; Algorithms; Aminolevulinic Acid; Brain Neoplasms; Computer Simulation; Finite Element Analysis; Fluorescence; Glioblastoma; Humans; Models, Biological; Models, Chemical; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation Dosage; Radiometry; Scattering, Radiation; Time Factors | 2011 |
Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells.
Topics: Aminolevulinic Acid; Apoptosis; Calcium; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Endoplasmic Reticulum; Humans; Light; Lymphoma; Mitochondria; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Protoporphyrins; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2011 |
δ-Aminolevulinic acid and its methyl ester induce the formation of Protoporphyrin IX in cultured sensory neurones.
Topics: Amino Acid Transport Systems; Aminolevulinic Acid; Animals; Biological Transport; Cells, Cultured; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; Ganglia, Spinal; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Time Factors | 2011 |
Protoporphyrin IX fluorescence contrast in invasive glioblastomas is linearly correlated with Gd enhanced magnetic resonance image contrast but has higher diagnostic accuracy.
Topics: Aminolevulinic Acid; Animals; Area Under Curve; Cell Line, Tumor; Diffusion; Gadolinium; Glioblastoma; Histocytochemistry; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Protoporphyrins; ROC Curve; Spectrometry, Fluorescence | 2011 |
Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy.
Topics: Adult; Aged; Aminolevulinic Acid; Apoptosis; Blotting, Western; Case-Control Studies; Caspase 3; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type III; Combined Modality Therapy; Electric Stimulation Therapy; Enzyme Activation; Female; Fibroblasts; Flow Cytometry; Gene Expression Regulation; Humans; Keloid; L-Lactate Dehydrogenase; Male; Matrix Metalloproteinase 2; Membrane Potential, Mitochondrial; Middle Aged; Necrosis; Photochemotherapy; Photosensitizing Agents; Polymerase Chain Reaction; Protoporphyrins; Reactive Oxygen Species; Time Factors | 2011 |
Modulating ALA-PDT efficacy of mutlidrug resistant MCF-7 breast cancer cells using ALA prodrug.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Levulinic Acids; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2011 |
Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell.
Topics: Aminolevulinic Acid; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Survival; Cholangiocarcinoma; Excipients; Humans; Photochemotherapy; Photosensitizing Agents; Poloxamer; Polysorbates; Protoporphyrins; Surface-Active Agents | 2012 |
Fluorescence detection and depletion of T47D breast cancer cells from human mononuclear cell-enriched blood preparations by photodynamic treatment: Basic in vitro experiments towards the removal of circulating tumor cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Endothelial Cells; Erythrocytes; Female; Flow Cytometry; Humans; Leukocytes, Mononuclear; Neoplastic Cells, Circulating; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats | 2011 |
Intracutaneous ALA photodynamic therapy: dose-dependent targeting of skin structures.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Subcutaneous Fat; Swine | 2011 |
Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Diagnostic Imaging; Glioma; Humans; Models, Biological; Protoporphyrins; Sensitivity and Specificity; Spectrometry, Fluorescence; Statistics, Nonparametric; Support Vector Machine; Surgery, Computer-Assisted | 2011 |
Fluorescence photobleaching of ALA and ALA-heptyl ester induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: a comparison of two light sources and different illumination schemes.
Topics: Aminolevulinic Acid; Animals; Esters; Female; Fluorescence; Lasers; Light; Mice; Mice, Hairless; Mice, Inbred BALB C; Models, Animal; Oxygen; Photobleaching; Photochemotherapy; Protoporphyrins; Skin; Time Factors | 2011 |
Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain.
Topics: Absorption; Aminolevulinic Acid; Diagnostic Imaging; Humans; Image Processing, Computer-Assisted; Light; Monte Carlo Method; Phantoms, Imaging; Photosensitizing Agents; Protoporphyrins; Reproducibility of Results; Scattering, Radiation; Skin; Spectrometry, Fluorescence | 2011 |
Photosensitizer-loaded dendrimer-modified multi-walled carbon nanotubes for photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Dendrimers; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Humans; Microscopy, Fluorescence; Nanotubes, Carbon; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Solubility; Stomach Neoplasms; Technology, Pharmaceutical; Time Factors | 2011 |
Comparison of noninvasive photodynamic therapy dosimetry methods using a dynamic model of ALA-PDT of human skin.
Topics: Aminolevulinic Acid; Computer Simulation; Humans; Models, Statistical; Optics and Photonics; Oxygen Consumption; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiography; Radiometry; Singlet Oxygen; Skin; Skin Neoplasms; Spectrometry, Fluorescence | 2012 |
Protoporphyrin IX-dependent photodynamic production of endogenous ROS stimulates cell proliferation.
Topics: Aminolevulinic Acid; Cell Cycle; Cell Proliferation; Humans; Keratinocytes; NADPH Oxidase 1; NADPH Oxidases; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; src-Family Kinases; Tumor Cells, Cultured | 2012 |
Porphyrin biodistribution in UV-exposed murine skin after methyl- and hexyl-aminolevulinate incubation.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biological Availability; Female; Humans; Mice; Mice, Hairless; Microscopy, Fluorescence; Models, Animal; Photochemotherapy; Photosensitizing Agents; Porphyrins; Precancerous Conditions; Protoporphyrins; Skin; Skin Neoplasms; Tissue Distribution; Ultraviolet Rays | 2012 |
Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Protoporphyrins; Radiation-Sensitizing Agents; Radiation, Ionizing; Rats; Reactive Oxygen Species | 2012 |
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
Topics: Aminolevulinic Acid; Anticonvulsants; Fluorescence; Glioma; Glutathione; Humans; Levetiracetam; Membrane Potential, Mitochondrial; Phenytoin; Photochemotherapy; Photosensitizing Agents; Piracetam; Protoporphyrins; Tumor Cells, Cultured | 2012 |
Stem cell-based photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Female; Fetal Blood; Imidazoles; Luciferases; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neural Stem Cells; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Plasmids; Protoporphyrins; Pyrazines; Rats; Stem Cell Transplantation; Stem Cells; Transfection | 2012 |
5-aminolevulinic acid-incorporated poly(vinyl alcohol) nanofiber-coated metal stent for application in photodynamic therapy.
Topics: Aminolevulinic Acid; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Survival; Cholangiocarcinoma; Drug-Eluting Stents; Humans; Microscopy, Electron, Scanning; Nanofibers; Nanomedicine; Photochemotherapy; Photosensitizing Agents; Polyvinyl Alcohol; Protoporphyrins | 2012 |
Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy.
Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; Colonic Neoplasms; Flow Cytometry; HCT116 Cells; HEK293 Cells; Histidine; Humans; Hydrogen-Ion Concentration; Models, Molecular; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2012 |
Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.
Topics: Aminolevulinic Acid; Apoptosis; ATP-Binding Cassette Transporters; Blotting, Western; Brain; Brain Neoplasms; Case-Control Studies; Cell Proliferation; Fluorescence; Glioma; Humans; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured | 2013 |
Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cytochromes c; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Protoporphyrins; Reactive Oxygen Species; Tongue Neoplasms; Transplantation, Heterologous; Ultrasonic Therapy | 2012 |
Validation of the protoporphyrin IX-triplet state lifetime technique for mitochondrial oxygen measurements in the skin.
Topics: Aminolevulinic Acid; Animals; Humans; Male; Mitochondria; Optical Phenomena; Oxygen; Protoporphyrins; Rats; Skin; Spectrometry, Fluorescence | 2012 |
Comparison of the uptake of 5-aminolevulinic acid and its methyl ester in keratinocytes and skin.
Topics: Amino Acids; Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; GABA Plasma Membrane Transport Proteins; Humans; Keratinocytes; Male; Mice; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Absorption | 2012 |
Weather conditions and daylight-mediated photodynamic therapy: protoporphyrin IX-weighted daylight doses measured in six geographical locations.
Topics: Aminolevulinic Acid; Dose-Response Relationship, Radiation; Europe; Geography, Medical; Humans; Israel; Keratosis, Actinic; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiometry; Residence Characteristics; Seasons; Skin Neoplasms; Sunlight; Temperature; Ultraviolet Rays; Weather | 2013 |
Differential cytotoxic response in keloid fibroblasts exposed to photodynamic therapy is dependent on photosensitiser precursor, fluence and location of fibroblasts within the lesion.
Topics: Adult; Aminolevulinic Acid; Apoptosis; Cell Differentiation; Cells, Cultured; Cellular Senescence; Female; Fibroblasts; Humans; Keloid; Male; Middle Aged; Photochemotherapy; Protoporphyrins; Reactive Oxygen Species; Skin | 2012 |
Automatic laser scanning ablation system for high-precision treatment of brain tumors.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Equipment Design; Glioma; Humans; Laser Therapy; Models, Animal; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Swine | 2013 |
Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown.
Topics: Aminolevulinic Acid; Blood-Brain Barrier; Brain Neoplasms; Craniotomy; Creatinine; Female; Gadolinium; Glioma; Humans; Magnetic Resonance Imaging; Male; Mass Spectrometry; Microvessels; Photosensitizing Agents; Platelet Endothelial Cell Adhesion Molecule-1; Protoporphyrins; Statistics as Topic; Statistics, Nonparametric | 2012 |
Protoporphyrin IX formation and photobleaching in different layers of normal human skin: methyl- and hexylaminolevulinate and different light sources.
Topics: Adolescent; Adult; Aminolevulinic Acid; Dermis; Epidermis; Humans; Lasers, Dye; Light; Microscopy, Fluorescence; Middle Aged; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Young Adult | 2012 |
The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Chelating Agents; Ethylenediamines; Humans; Male; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; X-Linked Inhibitor of Apoptosis Protein; Zinc | 2012 |
In vitro investigation of efficient photodynamic therapy using a nonviral vector; hemagglutinating virus of Japan envelope.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Humans; Lung Neoplasms; Melanoma, Experimental; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sendai virus; Spectrometry, Fluorescence; Viral Envelope Proteins | 2012 |
Modelling fluorescence in clinical photodynamic therapy.
Topics: Aminolevulinic Acid; Humans; Models, Theoretical; Monte Carlo Method; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiometry; Skin Diseases; Skin Neoplasms; Spectrometry, Fluorescence | 2013 |
Factors implicated in the assessment of aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Aminolevulinic Acid; Cell Communication; Cell Line, Tumor; Coculture Techniques; Collagen; Flow Cytometry; Fluorescence; Humans; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria; Neoplasms; Organ Specificity; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2013 |
Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation.
Topics: Adenosine; Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line, Tumor; Diketopiperazines; Doxorubicin; Endoplasmic Reticulum; Ferrochelatase; Gene Expression; Glycosylation; Golgi Apparatus; HEK293 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Mitochondria; Neoplasm Proteins; Peptide Transporter 1; Protein Transport; Protoporphyrins; Recombinant Fusion Proteins; Symporters; U937 Cells | 2012 |
Real-time, in vivo measurement of tissular pO2 through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Chick Embryo; Chorioallantoic Membrane; Fluorescence; Kinetics; Optical Phenomena; Oxygen; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tissue Distribution | 2012 |
[Intraoperative fluorescent visualization and laser spectrosopy in intrinsic brain tumor surgery].
Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Humans; Male; Middle Aged; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2012 |
In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cells.
Topics: Aminolevulinic Acid; Anthracenes; Cell Line, Tumor; Cerebellar Neoplasms; Humans; Medulloblastoma; Microscopy, Fluorescence; Perylene; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2012 |
Effects of 5-aminolevulinic acid-mediated sonodynamic therapy on macrophages.
Topics: Aminolevulinic Acid; Analysis of Variance; Cell Death; Cell Line; Cell Survival; Flow Cytometry; Humans; Macrophages; Membrane Potential, Mitochondrial; Protoporphyrins; Reactive Oxygen Species; Ultrasonic Therapy; Ultrasonics | 2013 |
Aminolevulinic acid derivatives-based photodynamic therapy in human intra- and extrahepatic cholangiocarcinoma cells.
Topics: Aminolevulinic Acid; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinoma; Dose-Response Relationship, Drug; Humans; Peptide Transporter 1; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Symporters | 2013 |
Photodynamic detection and management of intraperitoneal spreading of primary peritoneal papillary serous carcinoma in a man: report of a case.
Topics: Administration, Oral; Aminolevulinic Acid; Combined Modality Therapy; Cystadenocarcinoma, Papillary; Cystadenocarcinoma, Serous; Humans; Intraoperative Period; Male; Middle Aged; Peritoneal Neoplasms; Peritoneum; Photochemical Processes; Photosensitizing Agents; Protoporphyrins | 2014 |
Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Drug Combinations; Drug Synergism; Humans; Image Enhancement; Microscopy, Fluorescence; Neoplasms, Experimental; Photosensitizing Agents; Propyl Gallate; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity | 2013 |
Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma.
Topics: Aminolevulinic Acid; Angiogenesis Inhibitors; Animals; Apoptosis; Carcinoma, Transitional Cell; Cell Line; Deferoxamine; Enzyme Inhibitors; Ferrochelatase; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2013 |
5-aminolevulinic acid-incorporated nanoparticles of methoxy poly(ethylene glycol)-chitosan copolymer for photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Humans; Nanoparticles; Particle Size; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Protoporphyrins | 2013 |
Effects of 5-aminolevulinic acid-mediated photodynamic therapy on antibiotic-resistant staphylococcal biofilm: an in vitro study.
Topics: Aminolevulinic Acid; Animals; Biofilms; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Bacterial; In Vitro Techniques; Methicillin-Resistant Staphylococcus aureus; Microscopy, Electron, Scanning; Photochemotherapy; Protoporphyrins; Staphylococcus epidermidis; Treatment Outcome | 2013 |
Antitumor effect of combination of hyperthermotherapy and 5-aminolevulinic acid (ALA).
Topics: Aminolevulinic Acid; Animals; Carcinoma, Lewis Lung; Combined Modality Therapy; Female; Hyperthermia, Induced; Light; Lung Neoplasms; Mice; Mice, Inbred C57BL; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2013 |
Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.
Topics: Amino Acid Chloromethyl Ketones; Aminolevulinic Acid; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood Proteins; Carcinoma, Squamous Cell; Caspase Inhibitors; Cell Line, Tumor; Deferoxamine; Ferrochelatase; Gene Silencing; Humans; Lipid Peroxidation; Mouth Neoplasms; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Siderophores | 2013 |
Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX.
Topics: Aminolevulinic Acid; Binding, Competitive; Carbon Radioisotopes; Cells, Cultured; Chromatography, High Pressure Liquid; Humans; Molecular Structure; Neoplasms; Photosensitizing Agents; Positron-Emission Tomography; Protoporphyrins; Time Factors | 2013 |
Cisplatin enhances the efficacy of 5-aminolevulinic acid mediated photodynamic therapy in human head and neck squamous cell carcinoma.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Synergism; Female; Head and Neck Neoplasms; Humans; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tetrazolium Salts; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Detection of metastatic lymph nodes using 5-aminolevulinic acid in patients with gastric cancer.
Topics: Aminolevulinic Acid; Fluorescence; Humans; Lymph Nodes; Lymphatic Metastasis; Neoplasm Staging; Photosensitizing Agents; Prognosis; Protoporphyrins; ROC Curve; Stomach Neoplasms | 2013 |
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; Rats; Tumor Cells, Cultured | 2013 |
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Analysis of Variance; Cluster Analysis; Female; Fluorescence; Fluorescent Dyes; Humans; Light; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neoplasm Staging; Neurosurgical Procedures; Prospective Studies; Protoporphyrins; ROC Curve; Sensitivity and Specificity | 2014 |
Topical hexylaminolevulinate and aminolevulinic acid photodynamic therapy: complete arteriole vasoconstriction occurs frequently and depends on protoporphyrin IX concentration in vessel wall.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Arterioles; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Vasoconstriction | 2013 |
Differential sensitivity in cell lines to photodynamic therapy in combination with ABCG2 inhibition.
Topics: Adenosine; Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Diketopiperazines; Esters; Extracellular Space; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Humans; Intracellular Space; Isomerism; Neoplasm Proteins; Photochemotherapy; Protoporphyrins | 2013 |
Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Glioma; Heme; Humans; Intracellular Space; Oxides; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar | 2013 |
Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; Metabolic Clearance Rate; Neoplasm Proteins; Peptide Transporter 1; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction; Symporters; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2013 |
Efficiency of 5-ALA mediated photodynamic therapy on hypoxic prostate cancer: a preclinical study on the Dunning R3327-AT2 rat tumor model.
Topics: Aminolevulinic Acid; Animals; Cell Hypoxia; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Therapy, Combination; Male; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Rats; Treatment Outcome | 2013 |
Cadherin 13 overexpression as an important factor related to the absence of tumor fluorescence in 5-aminolevulinic acid-guided resection of glioma.
Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Cadherins; Cell Line, Tumor; Fluorescence; Gene Expression; Glioblastoma; Humans; Metabolic Networks and Pathways; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted | 2013 |
Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Astrocytes; Brain Neoplasms; Calcitriol; Cell Line, Tumor; Cell Survival; Enzymes; Fluorescence; Gene Expression Regulation, Neoplastic; Glioma; Humans; Molecular Imaging; Photochemotherapy; Protoporphyrins | 2014 |
Correlation between protoporphyrin IX fluorescence intensity, photobleaching, pain and clinical outcome of actinic keratosis treated by photodynamic therapy.
Topics: Aged; Aminolevulinic Acid; Fluorescence; Humans; Keratosis, Actinic; Middle Aged; Pain; Pain Measurement; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment Outcome | 2013 |
Accumulation and elimination of photosens and protoporphyrin IX by different types of mesenchymal cells.
Topics: Aminolevulinic Acid; Cell Survival; Cells, Cultured; Endothelial Cells; Humans; Indoles; Kinetics; Macrophages; Mesenchymal Stem Cells; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2013 |
Comparative kinetics of damage to the plasma and mitochondrial membranes by intra-cellularly synthesized and externally-provided photosensitizers using multi-color FACS.
Topics: Aminolevulinic Acid; Anthracyclines; Benzimidazoles; Carbocyanines; Cell Line, Tumor; Cell Membrane; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Light; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Neurons; Photosensitizing Agents; Protoporphyrins | 2014 |
5-Aminolevulinic acid induced fluorescence is a powerful intraoperative marker for precise histopathological grading of gliomas with non-significant contrast-enhancement.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Monitoring, Intraoperative; Prospective Studies; Protoporphyrins; Reproducibility of Results; Sensitivity and Specificity; Young Adult | 2013 |
The inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic action for prostate cancer.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Chloroquine; Deferoxamine; Drug Synergism; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins | 2013 |
Clearance mechanism of protoporphyrin IX from mouse skin after application of 5-aminolevulinic acid.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Female; In Vitro Techniques; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Skin; Tissue Distribution | 2013 |
Detection of lymph node metastases in human colorectal cancer by using 5-aminolevulinic acid-induced protoporphyrin IX fluorescence with spectral unmixing.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Colorectal Neoplasms; Female; Fluorescence; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Protoporphyrins | 2013 |
Optical glucose analogs of aminolevulinic acid for fluorescence-guided tumor resection and photodynamic therapy.
Topics: 4-Chloro-7-nitrobenzofurazan; Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glucosamine; Glucose; Humans; Male; Mesocricetus; Mice, SCID; Phloretin; Photochemotherapy; Protoporphyrins; Rats; Surgery, Computer-Assisted | 2014 |
[Photodynamic diagnosis and preoperative chemotherapy for biliary tract cancer].
Topics: Aminolevulinic Acid; Biliary Tract Neoplasms; Cell Line, Tumor; Humans; Microscopy, Electron, Scanning; Photochemical Processes; Protoporphyrins; Spectrometry, Fluorescence | 2013 |
Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience.
Topics: Aged; Aminolevulinic Acid; Anastomotic Leak; Carcinoma, Hepatocellular; Color; Colorectal Neoplasms; Female; Fluorescence; Hepatectomy; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm, Residual; Operative Time; Photosensitizing Agents; Protoporphyrins | 2014 |
Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema.
Topics: Adult; Aminolevulinic Acid; Erythema; Female; Humans; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen; Skin; Spectrometry, Fluorescence | 2014 |
Design and validation of a fiber optic point probe instrument for therapy guidance and monitoring.
Topics: Aminolevulinic Acid; Animals; Calibration; Carcinoma, Squamous Cell; Equipment Design; Fiber Optic Technology; Humans; Least-Squares Analysis; Light; Mice; Neoplasms; Optical Fibers; Phantoms, Imaging; Photochemotherapy; Protoporphyrins; Reproducibility of Results; Scattering, Radiation; Skin Neoplasms; Spectrophotometry; Support Vector Machine | 2014 |
A novel photodynamic therapy for drug-resistant prostate cancer cells using porphyrus envelope as a novel photosensitizer.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Drug Delivery Systems; Humans; Male; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Sendai virus | 2014 |
The effect of fluence rate on the acute response of vessel diameter and red blood cell velocity during topical 5-aminolevulinic acid photodynamic therapy.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Blood Flow Velocity; Dose-Response Relationship, Radiation; Erythrocytes; Mice; Mice, Nude; Photochemotherapy; Protoporphyrins; Radiation Dosage; Skin; Vasoconstriction | 2014 |
Optimization of photodynamic therapy using negative pressure.
Topics: Aminolevulinic Acid; Humans; Negative-Pressure Wound Therapy; Photochemotherapy; Protoporphyrins; Skin Cream | 2014 |
Identification of pathological and normal parathyroid tissue by fluorescent labeling with 5-aminolevulinic acid during endocrine neck surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Female; Humans; Male; Middle Aged; Neck; Parathyroid Glands; Parathyroidectomy; Protoporphyrins; Thoracic Surgery, Video-Assisted; Thyroid Gland; Thyroidectomy | 2014 |
Femtosecond laser induced photodynamic therapy on 5-ALA treated SKMEL-30 cells: an efficient theranostic strategy to combat melanoma.
Topics: Aged; Aminolevulinic Acid; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Fluorescence; Humans; Lasers; Male; Melanoma; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Time Factors | 2014 |
Exposure of mice to chronic hypoxia attenuates pulmonary arterial contractile responses to acute hypoxia by increases in extracellular hydrogen peroxide.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Antihypertensive Agents; Aorta; Cell Adhesion Molecules; Chronic Disease; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Familial Primary Pulmonary Hypertension; Hydrogen Peroxide; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Phosphoproteins; Phosphorylation; Protoporphyrins; Pulmonary Artery; Superoxide Dismutase; Superoxides; Time Factors; Up-Regulation; Vasoconstriction | 2014 |
[Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases].
Topics: Adult; Aged; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Count; Cell Line, Tumor; Female; Glioma; Humans; Male; Photosensitizing Agents; Protoporphyrins; Rats | 2014 |
Physiological oxygen concentration alters glioma cell malignancy and responsiveness to photodynamic therapy in vitro.
Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents, Phytogenic; Camptothecin; Caspase 3; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Survival; Extracellular Matrix Proteins; Female; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Oxygen; Photochemotherapy; Protoporphyrins | 2014 |
Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas.
Topics: Adult; Aminolevulinic Acid; Female; Fluorescence; Humans; Meningeal Neoplasms; Meningioma; Photosensitizing Agents; Protoporphyrins; Young Adult | 2014 |
Singlet oxygen and ROS in a new light: low-dose subcellular photodynamic treatment enhances proliferation at the single cell level.
Topics: Aminolevulinic Acid; Apoptosis; Cell Proliferation; HeLa Cells; Humans; Lasers; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Singlet Oxygen | 2014 |
Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chick Embryo; Metalloporphyrins; Mice; Neoplasms, Experimental; Protoporphyrins; Ultrasonic Therapy | 2014 |
Photodynamic diagnosis of shed prostate cancer cells in voided urine treated with 5-aminolevulinic acid.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biomarkers, Tumor; Feasibility Studies; Humans; Male; Microscopy, Fluorescence; Middle Aged; Photosensitizing Agents; Prospective Studies; Prostatic Neoplasms; Protoporphyrins; Sensitivity and Specificity; Urine | 2014 |
Real-time analysis of endogenous protoporphyrin IX fluorescence from δ-aminolevulinic acid and its derivatives reveals distinct time- and dose-dependent characteristics in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Cell Survival; Computer Systems; Dose-Response Relationship, Drug; Humans; Neoplasms, Experimental; Photochemotherapy; Protoporphyrins; Radiation-Sensitizing Agents; Spectrometry, Fluorescence | 2014 |
Preclinical characterization of 5-amino-4-oxo-[6-11C]hexanoic acid as an imaging probe to estimate protoporphyrin IX accumulation induced by exogenous aminolevulinic acid.
Topics: Aminocaproates; Aminolevulinic Acid; Animals; Cell Line, Tumor; Humans; Mice; Neoplasm Transplantation; Neoplasms; Positron-Emission Tomography; Protoporphyrins | 2014 |
Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Transport Complex I; Gene Expression; Hep G2 Cells; Humans; Ion Channels; Liver Neoplasms; Metalloporphyrins; Microscopy, Confocal; Mitochondria; Mitochondrial Proteins; Oxidants; Oxygen Consumption; Protoporphyrins; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Transcription Factors; Uncoupling Protein 2 | 2014 |
Assessment of ALA-induced PpIX production in porcine skin pretreated with microneedles.
Topics: Aminolevulinic Acid; Animals; Kinetics; Male; Needles; Prodrugs; Protoporphyrins; Skin; Sus scrofa | 2015 |
5-Aminolevulinic acid enhances cell death under thermal stress in certain cancer cell lines.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Death; Cell Line, Tumor; Ferrochelatase; Frataxin; Gene Expression Regulation, Neoplastic; Heat-Shock Response; Humans; Intracellular Space; Iron-Binding Proteins; Neoplasm Proteins; Protoporphyrins; Reactive Oxygen Species | 2015 |
Effects of bisphenol A on chlorophyll synthesis in soybean seedlings.
Topics: Aminolevulinic Acid; Analysis of Variance; Benzhydryl Compounds; Biosynthetic Pathways; Chlorophyll; Environmental Pollutants; Glycine max; Hydroxymethylbilane Synthase; Phenols; Photosynthesis; Plant Leaves; Porphobilinogen Synthase; Protoporphyrinogen Oxidase; Protoporphyrins; Seedlings; Spectrometry, Fluorescence; Uroporphyrinogen Decarboxylase; Uroporphyrinogen III Synthetase | 2015 |
Calcipotriol pretreatment enhances methyl aminolevulinate-induced protoporphyrin IX: an in vivo study in hairless mice.
Topics: Aminolevulinic Acid; Animals; Calcitriol; Dermatologic Agents; Female; Mice; Mice, Nude; Photosensitizing Agents; Protoporphyrins; Skin | 2015 |
Cutaneous mitochondrial respirometry: non-invasive monitoring of mitochondrial function.
Topics: Aminolevulinic Acid; Animals; Blood Gas Monitoring, Transcutaneous; Endotoxemia; Equipment Design; Healthy Volunteers; Heme; Humans; Lipopolysaccharides; Male; Mitochondria; Monitoring, Physiologic; Oxygen; Oxygen Consumption; Protoporphyrins; Rats; Rats, Wistar; Skin | 2015 |
5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Cytoplasm; Glioma; Humans; In Vitro Techniques; Photosensitizing Agents; Protoporphyrins; Rats; Reactive Oxygen Species; Time Factors; X-Rays | 2015 |
5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytotoxicity, Immunologic; Disease Models, Animal; Glioma; Male; Necrosis; Photochemotherapy; Protoporphyrins; Radiation Dosage; Radiation-Sensitizing Agents; Radiation, Ionizing; Rats; Tumor Burden | 2015 |
Induction of protoporphyrin IX in patient-derived synoviocytes, cartilage explants and chondrons after application of 5-aminolevulinic acid or its methyl ester.
Topics: Aminolevulinic Acid; Arthritis, Rheumatoid; Cartilage; Chondrocytes; Humans; Osteoarthritis; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Synovial Fluid | 2014 |
Multi-channel LED light source for fluorescent agent aided minimally invasive surgery.
Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Indocyanine Green; Light; Minimally Invasive Surgical Procedures; Neoplasms; Optical Imaging; Photosensitizing Agents; Protoporphyrins; Semiconductors | 2014 |
Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cell Line, Tumor; Female; Humans; Male; Middle Aged; Neoplasm Grading; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Spectrophotometry; Urinary Bladder Neoplasms | 2015 |
Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis.
Topics: Aminolevulinic Acid; Animals; Aorta; Atherosclerosis; Fluorescence; Gold; Male; Nanoparticles; Photosensitizing Agents; Polyethylene Glycols; Protoporphyrins; Rabbits | 2015 |
5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett's esophagus cellular models.
Topics: Aminolevulinic Acid; Barrett Esophagus; Cell Line, Tumor; Cell Survival; Humans; Intracellular Space; Models, Biological; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2015 |
Multidimensional visualization of healthy and sensitized rabbit knee tissues by means of confocal microscopy.
Topics: Aminolevulinic Acid; Animals; Cartilage; Chinchilla; Eosine Yellowish-(YS); Hematoxylin; Hindlimb; Joints; Male; Microscopy, Confocal; Microscopy, Fluorescence; Photosensitizing Agents; Porphyrins; Protoporphyrins; Rabbits; Spectrometry, Fluorescence; Synovial Membrane | 2015 |
5-Aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett's esophagus cellular models.
Topics: Adenocarcinoma; Algorithms; Aminolevulinic Acid; Barrett Esophagus; Biomarkers; Esophageal Neoplasms; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Photosensitizing Agents; Pilot Projects; Precancerous Conditions; Protoporphyrins; Sensitivity and Specificity | 2015 |
Correlation between treatment time, photobleaching, inflammation and pain after photodynamic therapy with methyl aminolevulinate on tape-stripped skin in healthy volunteers.
Topics: Adult; Aminolevulinic Acid; Erythema; Fluorescence; Forearm; Humans; Inflammation; Male; Middle Aged; Pain; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Pigmentation; Time Factors; White People; Young Adult | 2015 |
Low dose 5-aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Dose-Response Relationship, Drug; Female; Fluorescence; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Spectrometry, Fluorescence | 2015 |
The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Cation Transport Proteins; Cell Line, Tumor; Heme; Humans; Iron; MCF-7 Cells; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity | 2015 |
Monte Carlo modelling of daylight activated photodynamic therapy.
Topics: Algorithms; Aminolevulinic Acid; Humans; Light; Monte Carlo Method; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation Dosage; Skin | 2015 |
Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED).
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Glioblastoma; Humans; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Survival Analysis; Time Factors | 2015 |
Effect of cell cycle phase on the sensitivity of SAS cells to sonodynamic therapy using low-intensity ultrasound combined with 5-aminolevulinic acid in vitro.
Topics: Aminolevulinic Acid; Biotransformation; Caspase 3; Cell Cycle; Cell Line, Tumor; Cyclin A; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Protoporphyrins; Radiation Tolerance; Signal Transduction; Tongue; Ultrasonic Therapy; Ultrasonic Waves | 2015 |
Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy.
Topics: Aminolevulinic Acid; Caco-2 Cells; Cell Line, Tumor; Heme; Humans; K562 Cells; Kinetics; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; U937 Cells | 2015 |
Potential Molecular Mechanisms Involved in 5-Aminolevulinic Acid-Based Photodynamic Therapy against Human Hypertrophic Scars.
Topics: Aminolevulinic Acid; Apoptosis; Biomarkers; Blotting, Western; Cell Survival; Cells, Cultured; Cicatrix, Hypertrophic; Fibroblasts; Flow Cytometry; Humans; In Vitro Techniques; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Real-Time Polymerase Chain Reaction | 2015 |
Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Male; Middle Aged; Neuronavigation; Photosensitizing Agents; Protoporphyrins | 2015 |
Deconvoluting heme biosynthesis to target blood-stage malaria parasites.
Topics: Aminolevulinic Acid; Artemisinins; Biosynthetic Pathways; Erythrocytes; Heme; Humans; Lactones; Photosensitizing Agents; Plasmodium falciparum; Protoporphyrins; Reactive Oxygen Species | 2015 |
Induction of apoptosis in HPV16 E7 transfected human keratinocyte by ALA-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line; Humans; Keratinocytes; Light; Papillomavirus E7 Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Transfection; Treatment Outcome | 2016 |
Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cells, Cultured; Cystoscopy; Ferrochelatase; Humans; Microscopy, Fluorescence; Molecular Imaging; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms | 2016 |
Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Enzyme Stability; Escherichia coli; Genetic Diseases, X-Linked; HeLa Cells; Hot Temperature; Humans; K562 Cells; Kinetics; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Protoporphyria, Erythropoietic; Protoporphyrins; Thermodynamics | 2015 |
Immobilization of ALA-Zn(II) Coordination Polymer Pro-photosensitizers on Magnetite Colloidal Supraparticles for Target Photodynamic Therapy of Bladder Cancer.
Topics: Aminolevulinic Acid; Blotting, Western; Cell Death; Cell Line, Tumor; Colloids; Ferrosoferric Oxide; Humans; Microspheres; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Polymers; Powders; Protoporphyrins; Temperature; Thermogravimetry; Urinary Bladder Neoplasms; X-Linked Inhibitor of Apoptosis Protein; X-Ray Diffraction; Zinc | 2015 |
Epidermal penetration and protoporphyrin IX formation of two different 5-aminolevulinic acid formulations in ex vivo human skin.
Topics: Adult; Aminolevulinic Acid; Epidermis; Female; Humans; Male; Middle Aged; Models, Biological; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2016 |
Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis.
Topics: Aminolevulinic Acid; Animals; Cell Death; Heme; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Mitochondria; Protoporphyrins; Receptors, GABA | 2016 |
Fluorescence characteristics of human Barrett tissue specimens grafted on chick chorioallantoic membrane.
Topics: Aminolevulinic Acid; Animals; Barrett Esophagus; Biopsy; Chickens; Chorioallantoic Membrane; Humans; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2016 |
Dexamethasone alone and in combination with desipramine, phenytoin, valproic acid or levetiracetam interferes with 5-ALA-mediated PpIX production and cellular retention in glioblastoma cells.
Topics: Aminolevulinic Acid; Anti-Inflammatory Agents; Anticonvulsants; Desipramine; Dexamethasone; Drug Therapy, Combination; Enzyme Inhibitors; Fluorescence; Glioblastoma; Humans; Levetiracetam; Phenytoin; Photosensitizing Agents; Piracetam; Protoporphyrins; Valproic Acid | 2016 |
Skin tumor development after UV irradiation and photodynamic therapy is unaffected by short-term pretreatment with 5-fluorouracil, imiquimod and calcipotriol. An experimental hairless mouse study.
Topics: Aminolevulinic Acid; Aminoquinolines; Animals; Calcitriol; Carcinoma, Squamous Cell; Female; Fluorouracil; Imiquimod; Mice; Mice, Hairless; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Skin Neoplasms; Ultraviolet Rays | 2016 |
Can basal cell carcinoma lateral border be determined by fluorescence diagnosis?: Verification by Mohs micrographic surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Diagnostic Techniques, Surgical; Female; Fluorescence; Humans; Male; Middle Aged; Mohs Surgery; Protoporphyrins; Skin Neoplasms | 2016 |
A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.
Topics: Aminolevulinic Acid; Animals; Deferoxamine; Disease Models, Animal; Genetic Predisposition to Disease; Larva; Liver; Mice; Photosensitizing Agents; Protein Aggregation, Pathological; Protoporphyria, Erythropoietic; Protoporphyrins; Siderophores; Stress, Physiological; Zebrafish | 2016 |
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Hyperthermia, Induced; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Protoporphyrins; Reactive Oxygen Species; Ultrasonic Therapy; Xenograft Model Antitumor Assays | 2016 |
Short-term chemical pretreatment cannot replace curettage in photodynamic therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Curettage; Dermatologic Agents; Drug Therapy, Combination; Female; Fluorescence; Healthy Volunteers; Humans; Keratolytic Agents; Male; Middle Aged; Ointments; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Salicylic Acid; Young Adult | 2016 |
Light Fractionation Significantly Increases the Efficacy of Photodynamic Therapy Using BF-200 ALA in Normal Mouse Skin.
Topics: Aminolevulinic Acid; Animals; Animals, Outbred Strains; Dose Fractionation, Radiation; Drug Evaluation, Preclinical; Endothelial Cells; Female; Mice; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; Sus scrofa | 2016 |
Ablative fractional laser enhances MAL-induced PpIX accumulation: Impact of laser channel density, incubation time and drug concentration.
Topics: Adolescent; Adult; Aminolevulinic Acid; Humans; Lasers; Male; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Young Adult | 2016 |
Highly sensitive fluorescence detection of metastatic lymph nodes of gastric cancer with photo-oxidation of protoporphyrin IX.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cell Line, Tumor; Female; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Light; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Optical Imaging; Oxidation-Reduction; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Stomach Neoplasms | 2016 |
Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions.
Topics: Aminolevulinic Acid; Biotransformation; Cell Line, Tumor; Collagen; Colorectal Neoplasms; Flavins; Fluorescent Dyes; Humans; Image Processing, Computer-Assisted; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Optical Imaging; Protoporphyrins; Signal-To-Noise Ratio; Software | 2016 |
eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy.
Topics: Aminolevulinic Acid; Biological Availability; Cell Line; Gene Library; Hep G2 Cells; Humans; Neoplasms; Peptide Elongation Factor 1; Photochemotherapy; Photosensitizing Agents; Protein Binding; Protoporphyrins | 2016 |
Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Neuropeptides; Photochemotherapy; Photosensitizing Agents; Porphyrias; Protoporphyrins; Reactive Oxygen Species; Sensory Receptor Cells; Skin; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2016 |
Tumor reactive ringlet oxygen approach for Monte Carlo modeling of photodynamic therapy dosimetry.
Topics: Aminolevulinic Acid; Humans; Models, Theoretical; Monte Carlo Method; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen | 2016 |
Tunable phosphatase-sensitive stable prodrugs of 5-aminolevulinic acid for tumor fluorescence photodetection.
Topics: Alkaline Phosphatase; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Fluorescence; Glioblastoma; Humans; Photochemotherapy; Prodrugs; Protoporphyrins; Spheroids, Cellular | 2016 |
Plum-blossom needling promoted PpIX fluorescence intensity from 5-aminolevulinic acid in porcine skin model and patients with actnic keratosis.
Topics: Acupuncture Therapy; Aged; Aminolevulinic Acid; Animals; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Keratosis, Actinic; Male; Microscopy, Fluorescence; Middle Aged; Photosensitizing Agents; Protoporphyrins; Skin; Skin Absorption; Swine | 2016 |
The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Histidine; Humans; Iron Chelating Agents; Metalloporphyrins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Pyridones; Reactive Oxygen Species | 2016 |
Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Female; Heme; Humans; Lasers, Semiconductor; Lighting; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Random Allocation; Siderophores; Skin Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Human glioblastoma stem-like cells accumulate protoporphyrin IX when subjected to exogenous 5-aminolaevulinic acid, rendering them sensitive to photodynamic treatment.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Glioblastoma; Humans; Neoplastic Stem Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Time Factors | 2016 |
Photodynamic Diagnosis of Hepatocellular Carcinoma Using 5-Aminolevulinic Acid.
Topics: Aged; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Embolization, Therapeutic; Female; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Middle Aged; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2016 |
Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Coproporphyrinogen Oxidase; Fluorescence; Glioma; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2017 |
Optimization and therapeutic effects of PDT mediated by ALA and MAL in the treatment of cutaneous malignant lesions: A comparative study.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Female; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 2016 |
Zwitterionic stealth peptide-capped 5-aminolevulinic acid prodrug nanoparticles for targeted photodynamic therapy.
Topics: Amino Acid Sequence; Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Drug Liberation; Gold; Humans; Hydrogen-Ion Concentration; Light; Nanoparticles; Peptides; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2017 |
Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX.
Topics: Amines; Aminolevulinic Acid; Animals; Cell Membrane; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Photochemotherapy; Photosensitizing Agents; Picolinic Acids; Protoporphyrins; Zinc | 2016 |
Multispectral autofluorescence imaging for detection of cervical lesions: A preclinical study.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Disease Models, Animal; Female; Human papillomavirus 16; Humans; Mice; Mice, Nude; Optical Imaging; Photochemotherapy; Protoporphyrins; Uterine Cervical Neoplasms | 2016 |
Evaluation of Hydrogel Suppositories for Delivery of 5-Aminolevulinic Acid and Hematoporphyrin Monomethyl Ether to Rectal Tumors.
Topics: Administration, Intravenous; Administration, Topical; Aminolevulinic Acid; Animals; Cell Line, Tumor; Hematoporphyrins; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rectal Neoplasms; Suppositories; Xenograft Model Antitumor Assays | 2016 |
A consensus on the use of daylight photodynamic therapy in the UK.
Topics: Aminolevulinic Acid; Consensus; Humans; Keratosis, Actinic; Light; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; United Kingdom | 2017 |
Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters.
Topics: Adult; Aminolevulinic Acid; Female; Glioma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mutation; Postoperative Care; Preoperative Care; Protoporphyrins; Retrospective Studies; Sensitivity and Specificity; Supratentorial Neoplasms; Tumor Suppressor Protein p53 | 2017 |
Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Male; Photochemotherapy; Photosensitizing Agents; Prostatic Neoplasms; Protoporphyrins; Spheroids, Cellular | 2016 |
Sonodynamic Therapy Inhibits Fibrogenesis in Rat Cardiac Fibroblasts Induced by TGF-β1.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Proliferation; Cell Survival; Collagen; Fibroblasts; Fibrosis; Glycogen Synthase Kinase 3 beta; Intracellular Space; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Protoporphyrins; Rats, Sprague-Dawley; Smad3 Protein; Transforming Growth Factor beta1; Ultrasonics | 2016 |
Lack of effect of selected sunscreens applied on ex vivo human skin for 5-methyl-aminolevulinic acid penetration and protoporphyrin IX photoactivation.
Topics: Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Absorption; Sunscreening Agents | 2017 |
A monitor for Cellular Oxygen METabolism (COMET): monitoring tissue oxygenation at the mitochondrial level.
Topics: Aminolevulinic Acid; Biocompatible Materials; Equipment Design; Humans; Lasers; Microcirculation; Mitochondria; Monitoring, Ambulatory; Oxygen; Oxygen Consumption; Protoporphyrins; Signal Processing, Computer-Assisted; Skin | 2017 |
Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model.
Topics: Aminolevulinic Acid; Glucose; Models, Biological; Oxygen; Protoporphyrins; Saccharomyces cerevisiae; Spectrometry, Fluorescence | 2016 |
Nitric oxide-mediated resistance to photodynamic therapy in a human breast tumor xenograft model: Improved outcome with NOS2 inhibitors.
Topics: Amidines; Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzoates; Benzylamines; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Female; Heterografts; Humans; Imidazoles; Light; Mice, SCID; Neoplasm Invasiveness; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sulfides; Up-Regulation | 2017 |
5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells.
Topics: Aminolevulinic Acid; Apoptosis; Biological Transport; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Glioma; Humans; Intracellular Space; Mitochondria; Protoporphyrins; Radiation, Ionizing; Reactive Oxygen Species; Stress, Physiological | 2017 |
Photodynamic Therapy Effectively Treats Actinic Keratoses Without Pre-Illumination Incubation Time.
Topics: Aminolevulinic Acid; Face; Humans; Keratosis, Actinic; Male; Middle Aged; Pain; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Scalp; Sunlight; Time Factors; Treatment Outcome | 2017 |
Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology.
Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Diagnostic Imaging; Disease-Free Survival; Glioma; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Optics and Photonics; Phantoms, Imaging; Protoporphyrins; Sepharose; Signal-To-Noise Ratio | 2017 |
Activity of phosphatase-sensitive 5-aminolevulinic acid prodrugs in cancer cell lines.
Topics: A549 Cells; Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Humans; Light; MCF-7 Cells; Microscopy, Confocal; Neoplasms; Phosphoric Monoester Hydrolases; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2017 |
Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite.
Topics: Aminolevulinic Acid; Anti-Bacterial Agents; Biosynthetic Pathways; Drug Resistance, Bacterial; Escherichia coli; Genome, Bacterial; Heme; Iron Deficiencies; Metalloids; Microbial Sensitivity Tests; Models, Biological; Mutation; Protoporphyrins; Superoxides; Tellurium | 2017 |
Characterization of first hemin-requiring Pseudomonas aeruginosa small-colony variants from the blood of an octogenarian male-patient with double pneumonitis.
Topics: Aged, 80 and over; Amino Acid Sequence; Aminolevulinic Acid; Base Sequence; Culture Media; Hemin; Humans; Male; Pneumonia, Bacterial; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas Infections; RNA, Ribosomal, 16S; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2017 |
ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Glioma; Humans; Hypothermia, Induced; Magnetic Resonance Imaging; Male; Neurons; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Inbred F344; Rats, Wistar; Temperature | 2017 |
Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors.
Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Electronic Data Processing; Glioma; Humans; Neurosurgery; Optical Imaging; Phantoms, Imaging; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted | 2017 |
Protein 4.1R is Involved in the Transport of 5-Aminolevulinic Acid by Interaction with GATs in MEF Cells.
Topics: Aminolevulinic Acid; Analysis of Variance; Animals; Cell Line; Fibroblasts; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Mice; Mice, Knockout; Microfilament Proteins; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Tiagabine | 2018 |
Synthesis and evaluation of new 5-aminolevulinic acid derivatives as prodrugs of protoporphyrin for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred Strains; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Structure-Activity Relationship; Tumor Cells, Cultured | 2017 |
Intraoperative 5-aminolevulinic acid-induced photodynamic diagnosis of metastatic brain tumors with histopathological analysis.
Topics: Adult; Aged; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Fluorescence; Humans; Intraoperative Care; Magnetic Resonance Imaging; Male; Margins of Excision; Middle Aged; Neoplasm Invasiveness; Neurosurgical Procedures; Photosensitizing Agents; Protoporphyrins; Retrospective Studies; Surgery, Computer-Assisted | 2017 |
Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ.
Topics: Aminolevulinic Acid; Animals; Biomarkers; Dose-Response Relationship, Drug; Female; Keratinocytes; Lighting; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin; STAT3 Transcription Factor; Sunlight | 2017 |
Photodynamic therapy using a cytotoxic photosensitizer porphyrus envelope that targets the cell membrane.
Topics: Aminolevulinic Acid; Cell Death; Cell Line, Tumor; Drug Delivery Systems; Humans; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sendai virus; Viral Envelope Proteins | 2017 |
Quantifying the radiant exposure and effective dose in patients treated for actinic keratoses with topical photodynamic therapy using daylight and LED white light.
Topics: Administration, Topical; Aminolevulinic Acid; Humans; Keratosis, Actinic; Light; Lighting; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiation Dosage; Radiometry | 2018 |
Image Gallery: Pitfalls when measuring protoporphyrin IX during photodynamic therapy.
Topics: Aminolevulinic Acid; Humans; Microscopy, Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2017 |
Novel potential photodynamic therapy strategy using 5-Aminolevulinic acid for ovarian clear-cell carcinoma.
Topics: Adenocarcinoma, Clear Cell; Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Combined Modality Therapy; Female; Humans; Ovarian Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2018 |
Poly(methyl vinyl ether-alt-maleic acid) and ethyl monoester as building polymers for drug-loadable electrospun nanofibers.
Topics: Aminolevulinic Acid; Cell Line; Drug Carriers; Drug Liberation; Electricity; Esters; Humans; Maleic Anhydrides; Nanofibers; Photochemotherapy; Polyvinyls; Protoporphyrins | 2017 |
Resistance of oral cancer cells to 5-ALA-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Humans; Mouth Neoplasms; Photochemotherapy; Protoporphyrins; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines.
Topics: Adenocarcinoma; Aminolevulinic Acid; Breast Neoplasms; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Liver Neoplasms; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Singlet Oxygen | 2018 |
Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Biotransformation; Brain Neoplasms; Cell Line, Tumor; Female; Fiber Optic Technology; Fluorescent Dyes; Genes, Reporter; Glioma; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Fluorescence; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Transplantation; Neuroendoscopes; Neuroendoscopy; Photobleaching; Photosensitizing Agents; Protoporphyrins; Single-Cell Analysis; Surgery, Computer-Assisted | 2018 |
Verification of radiodynamic therapy by medical linear accelerator using a mouse melanoma tumor model.
Topics: Aminolevulinic Acid; Animals; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Particle Accelerators; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Tumor Cells, Cultured; X-Rays | 2018 |
Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo.
Topics: Aminolevulinic Acid; Cell Culture Techniques; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Photopheresis; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; T-Lymphocytes | 2018 |
Spectrophotometric photodynamic diagnosis of prostate cancer cells excreted in voided urine using 5-aminolevulinic acid.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Area Under Curve; Biomarkers, Tumor; Biopsy; Cell Line, Tumor; Humans; Male; Middle Aged; Multivariate Analysis; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Protoporphyrins; Spectrophotometry | 2018 |
Photodynamic diagnosis with methyl-5-aminolevulinate in squamous intraepithelial lesions of the vulva: Experimental research.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Cell Line; Computer Systems; Female; Heterografts; Humans; Mice; Protoporphyrins; Spectrometry, Fluorescence; Squamous Intraepithelial Lesions of the Cervix; Tissue Distribution; Vulvar Neoplasms | 2018 |
Potential involvement of the 18 kDa translocator protein and reactive oxygen species in apoptosis of THP-1 macrophages induced by sonodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; Cytochromes c; Humans; Macrophages; Membrane Potential, Mitochondrial; Mitochondria; Protoporphyrins; Reactive Oxygen Species; Receptors, GABA; THP-1 Cells; Ultrasonic Therapy | 2018 |
A Simply Modified Lymphocyte for Systematic Cancer Therapy.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Lasers; Levulinic Acids; Lymph Nodes; Lymphocytes; Microscopy, Fluorescence; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; ras Proteins; Reactive Oxygen Species; Tissue Distribution | 2018 |
Measurements of the optical coefficients of the protoporphyrin IX endogenously producing yeast-based model in the visible and NIR.
Topics: Aminolevulinic Acid; Models, Biological; Monte Carlo Method; Phantoms, Imaging; Protoporphyrins; Spectroscopy, Near-Infrared; Yeasts | 2018 |
Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?
Topics: Adult; Aminolevulinic Acid; Biomarkers; Biopsy; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Prognosis; Protoporphyrins | 2019 |
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Equipment Design; Female; Fluorescence; Fluorescent Dyes; Glioma; Mice, Mutant Strains; Microscopy, Fluorescence; Neoplasms, Experimental; Neuronavigation; Neurosurgical Procedures; Photobleaching; Protoporphyrins | 2018 |
A study of concentration changes of Protoporphyrin IX and Coproporphyrin III in mixed samples mimicking conditions inside cancer cells for Photodynamic Therapy.
Topics: Aminolevulinic Acid; Animals; Coproporphyrins; Equipment Design; Fiber Optic Technology; In Vitro Techniques; Neoplasms; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2018 |
Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioblastoma; Humans; Laser Therapy; Mass Spectrometry; Microscopy, Fluorescence; Molecular Conformation; Optical Imaging; Prodrugs; Protoporphyrins | 2018 |
Nonlinear relation between concentration and fluorescence emission of protoporphyrin IX in calibrated phantoms.
Topics: Aminolevulinic Acid; Calibration; Nonlinear Dynamics; Phantoms, Imaging; Protoporphyrins; Spectrometry, Fluorescence | 2018 |
Design and validation of an open-source modular Microplate Photoirradiation System for high-throughput photobiology experiments.
Topics: Aminolevulinic Acid; Computer Graphics; Humans; Light; Photobiology; Photobleaching; Photochemotherapy; Photosensitivity Disorders; Protoporphyrins; Radiation; Wireless Technology | 2018 |
Metabolic abnormalities in adult T-cell leukemia/lymphoma and induction of specific leukemic cell death using photodynamic therapy.
Topics: Adult; Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Humans; Leukemia-Lymphoma, Adult T-Cell; Metabolomics; Photochemotherapy; Protoporphyrins | 2018 |
Sequentially self-assembled polysaccharide-based nanocomplexes for combined chemotherapy and photodynamic therapy of breast cancer.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Chitosan; Doxorubicin; Drug Carriers; Drug Liberation; Fluorescence; Humans; Hyaluronic Acid; Light; MCF-7 Cells; Mice; Nanoparticles; Particle Size; Photosensitizing Agents; Protoporphyrins | 2019 |
Accumulation of protoporphyrin IX in medulloblastoma cell lines and sensitivity to subsequent photodynamic treatment.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Ferrochelatase; Humans; Medulloblastoma; Photochemotherapy; Protoporphyrins | 2018 |
Improving in vitro photodynamic therapy through the development of a novel iron chelating aminolaevulinic acid prodrug.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Humans; Iron Chelating Agents; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Pyridones; Skin Neoplasms | 2019 |
Comparative Study of the Effects of Ferrochelatase-siRNA Transfection Mediated by Ultrasound Microbubbles and Polyethyleneimine in Combination with Low-dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Endometrial Neoplasms; Female; Ferrochelatase; Humans; Mice; Mice, Nude; Microbubbles; Neoplasms, Experimental; Photosensitizing Agents; Polyethyleneimine; Protoporphyrins; RNA, Small Interfering; Ultrasonics; Xenograft Model Antitumor Assays | 2019 |
Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cel
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blotting, Western; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Ferrochelatase; Heme Oxygenase-1; Humans; Lung Neoplasms; Neoplasm Metastasis; Peptide Transporter 1; Photochemotherapy; Protoporphyrins; Real-Time Polymerase Chain Reaction; Spectrometry, Fluorescence; Uroporphyrinogens | 2019 |
Enhancing magnetic resonance/photoluminescence imaging-guided photodynamic therapy by multiple pathways.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Female; Fluorescence; Luminescence; Magnetic Resonance Imaging; Mice, Inbred BALB C; Nanoparticles; Photochemotherapy; Protoporphyrins; Subcellular Fractions; Theranostic Nanomedicine; Tissue Distribution | 2019 |
Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid-mediated Protoporphyrin IX by Iron Chelator Deferoxamine.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Deferoxamine; Epithelial Cells; Female; Ferrochelatase; Gene Silencing; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Siderophores | 2019 |
Mitotic Catastrophe Induced in HeLa Tumor Cells by Photodynamic Therapy with Methyl-aminolevulinate.
Topics: Aminolevulinic Acid; Biomarkers; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; HeLa Cells; Humans; Microtubules; Mitosis; Photochemotherapy; Photosensitizing Agents; Protein Transport; Protoporphyrins; Spindle Apparatus | 2019 |
Daylight PDT acts by continuous activation of PpIX.
Topics: Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sunlight; Time Factors | 2019 |
Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Kinetics; Male; Middle Aged; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence; Young Adult | 2019 |
ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Diketopiperazines; Female; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Neoplasm Proteins; Neoplasm Transplantation; Neoplastic Stem Cells; Photosensitizing Agents; Protoporphyrins; Single-Cell Analysis; Up-Regulation | 2019 |
Optimizing 5-ALA Induced Fluorescence Visualization: Comment Regarding Recent Article on Fluorescence-Based Real-Time Kinetics Protoporphyrin-IX Measurements Article in Neurosurgery.
Topics: Aminolevulinic Acid; Fluorescence; Glioma; Humans; Kinetics; Neurosurgery; Photosensitizing Agents; Protoporphyrins | 2019 |
Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Drug Synergism; Glioblastoma; Humans; Methadone; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2019 |
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Oxygen; Photosensitivity Disorders; Photosensitizing Agents; Porphyrias; Porphyrins; Protein Aggregates; Protein Conformation; Protoporphyrins | 2019 |
Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Dynamin II; Exocytosis; Heme; Humans; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Trimethyl Ammonium Compounds; Ultraviolet Rays | 2019 |
Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Humans; Membrane Transport Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; RNA, Small Interfering | 2019 |
Is the Intensity of 5-Aminolevulinic Acid-Derived Fluorescence Related to the Light Source?
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Light; Neurosurgical Procedures; Protoporphyrins | 2019 |
Quantification of PpIX-fluorescence of cerebral metastases: a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescent Dyes; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; Optical Imaging; Pilot Projects; Prognosis; Prospective Studies; Protoporphyrins | 2019 |
Fluorescence-based discrimination of breast cancer cells by direct exposure to 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Biopsy, Fine-Needle; Breast Neoplasms; Cell Line, Tumor; Diketopiperazines; Female; Heterocyclic Compounds, 4 or More Rings; Humans; MCF-7 Cells; Mice; Microscopy, Confocal; Protoporphyrins; Xenograft Model Antitumor Assays | 2019 |
Biosensor device for the photo-specific detection of immuno-captured bladder cancer cells using hexaminolevulinate: An ex-vivo study.
Topics: Aminolevulinic Acid; Biosensing Techniques; Cell Line, Tumor; Cystoscopy; Humans; In Vitro Techniques; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Urinary Bladder Neoplasms; Urine | 2019 |
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.
Topics: Adolescent; Aminolevulinic Acid; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Fluorescence; Glioma; Humans; Infant; Male; Protoporphyrins; Spectrum Analysis | 2019 |
Impact of thiosemicarbazones on the accumulation of PpIX and the expression of the associated genes.
Topics: A549 Cells; Aminolevulinic Acid; Antineoplastic Agents; Cell Survival; Drug Design; Ferrochelatase; Gene Expression Regulation; HCT116 Cells; Heme Oxygenase (Decyclizing); Humans; Iron; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Thiosemicarbazones | 2019 |
Antimalarial Drugs Enhance the Cytotoxicity of 5-Aminolevulinic Acid-Based Photodynamic Therapy against the Mammary Tumor Cells of Mice In Vitro.
Topics: Acetylcysteine; Aminolevulinic Acid; Animals; Antimalarials; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Shape; Female; Fluorescence; Mammary Neoplasms, Animal; Mice; Photochemotherapy; Protoporphyrins; Reactive Oxygen Species | 2019 |
Use of dermograph for improvement of PpIX precursor's delivery in photodynamic therapy: Experimental and clinical pilot studies.
Topics: Aminolevulinic Acid; Animals; Neoplasm Recurrence, Local; Photochemotherapy; Photosensitizing Agents; Pilot Projects; Protoporphyrins; Rats; Skin Neoplasms | 2020 |
Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Fluorescent Dyes; Genistein; Glioblastoma; Heme Oxygenase-1; Humans; Metalloporphyrins; Microscopy, Confocal; Neoplasm Proteins; Protoporphyrins | 2019 |
Smartphone fluorescence imager for quantitative dosimetry of protoporphyrin-IX-based photodynamic therapy in skin.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Equipment Design; Humans; Imaging, Three-Dimensional; Keratosis, Actinic; Mice; Mice, Nude; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiometry; Smartphone | 2019 |
The effect of glucose and human serum on 5-aminolevulinic acid mediated photodynamic inactivation of Candida albicans.
Topics: Aminolevulinic Acid; Biofilms; Candida albicans; Cell Survival; Cells, Cultured; Glucose; Humans; Lasers, Semiconductor; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Serum | 2020 |
Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cluster Analysis; Computer Simulation; Glioma; Humans; Machine Learning; Margins of Excision; Pilot Projects; Predictive Value of Tests; Prognosis; Protoporphyrins; Spectrometry, Fluorescence | 2020 |
Skin surface Protoporphyrin IX fluorescence is associated with epidermal but not dermal fluorescence intensities.
Topics: Aminolevulinic Acid; Epidermis; Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2020 |
Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Cell Count; Female; Fluorescence; Glioma; Humans; Male; Margins of Excision; Microscopy, Fluorescence; Middle Aged; Neurosurgical Procedures; Photosensitizing Agents; Predictive Value of Tests; Prospective Studies; Protoporphyrins; Surgery, Computer-Assisted | 2020 |
5-ALA-assistant automated detection of lymph node metastasis in gastric cancer patients.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Fluorescent Dyes; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Photosensitizing Agents; Prognosis; Protoporphyrins; Retrospective Studies; Stomach Neoplasms | 2020 |
Fluorescence detection of deep intramucosal cancer excited by green light for photodynamic diagnosis using protoporphyrin IX induced by 5-aminolevulinic acid: an ex vivo study.
Topics: Aminolevulinic Acid; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Fluorescence; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Stomach Neoplasms; Swine | 2020 |
DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; DNA Breaks, Double-Stranded; Melanoma; Mice; Protoporphyrins; Radiation-Sensitizing Agents; Reactive Oxygen Species; X-Ray Therapy; X-Rays | 2020 |
Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Fluorescence; Gene Expression; Glioma; Humans; Protoporphyrins; RNA, Messenger; Ultrasonography | 2021 |
Probing Hexaminolevulinate Mediated PpIX Fluorescence in Cancer Cell Suspensions in the Presence of Chemical Adjuvants.
Topics: Aminolevulinic Acid; Biosynthetic Pathways; Cell Line, Tumor; Fluorescence; Heme; Humans; Molecular Imaging; Photosensitizing Agents; Protoporphyrins | 2020 |
Temperature effect on the PpIX production during the use of topical precursors.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Male; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar; Temperature | 2020 |
Evaluation of the effect of 5-aminolevulinic acid hexyl ester (H-ALA) PDT on EBV LMP1 protein expression in human nasopharyngeal cells.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Herpesvirus 4, Human; Humans; Lasers, Semiconductor; Low-Level Light Therapy; Nasopharyngeal Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Viral Matrix Proteins | 2020 |
Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas.
Topics: Aminolevulinic Acid; Fluorescence; Glioblastoma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted | 2020 |
Epigallocatechin Gallate Enhances MAL-PDT Cytotoxic Effect on PDT-Resistant Skin Cancer Squamous Cells.
Topics: Aminolevulinic Acid; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Catechin; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Ferrochelatase; Heat-Shock Proteins; Humans; Membrane Transport Proteins; Molecular Chaperones; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Skin Neoplasms; Stress, Physiological; Superoxide Dismutase; Survivin; Symporters | 2020 |
In-vitro investigation of cold atmospheric plasma induced photodynamic effect by Indocyanine green and Protoporphyrin IX.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Humans; Indocyanine Green; Photochemotherapy; Photosensitizing Agents; Plasma Gases; Protoporphyrins | 2020 |
Relationship between tumor cell infiltration and 5-aminolevulinic acid fluorescence signals after resection of MR-enhancing lesions and its prognostic significance in glioblastoma.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Cell Movement; Cerebral Ventricles; DNA Modification Methylases; DNA Repair Enzymes; Female; Fluorescence; Glioblastoma; Humans; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Photosensitizing Agents; Prognosis; Progression-Free Survival; Protoporphyrins; Retrospective Studies; Tumor Suppressor Proteins | 2021 |
A facile fabrication of dissolving microneedles containing 5-aminolevulinic acid.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Drug Delivery Systems; Drug Stability; Drug Storage; Hyaluronic Acid; Needles; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Rats; Skin; Solubility | 2020 |
ABCG2 influence on the efficiency of photodynamic therapy in glioblastoma cells.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Doxycycline; Glioblastoma; Humans; Light; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Up-Regulation | 2020 |
Evaluation of aminolevulinic acid-mediated protoporphyrin IX fluorescence and enhancement by ABCG2 inhibitors in renal cell carcinoma cells.
Topics: Aminolevulinic Acid; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Carcinoma, Renal Cell; Cell Line, Tumor; Drug Screening Assays, Antitumor; Ferrochelatase; Humans; Kidney Neoplasms; Lapatinib; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction | 2020 |
Dissolving microneedles containing aminolevulinic acid improves protoporphyrin IX distribution.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Mice; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin | 2021 |
Rapid (FLASH-FLIM) imaging of protoporphyrin IX in a lipid mixture using a CMOS based widefield fluorescence lifetime imaging camera in real time for margin demarcation applications.
Topics: Aminolevulinic Acid; Lipids; Optical Imaging; Protoporphyrins | 2021 |
Thermo-Mechanical Fractional Injury Enhances Skin Surface- and Epidermis- Protoporphyrin IX Fluorescence: Comparison of 5-Aminolevulinic Acid in Cream and Gel Vehicles.
Topics: Aminolevulinic Acid; Epidermis; Humans; Photochemotherapy; Protoporphyrins | 2021 |
Modulation of aminolevulinic acid-based photoinactivation efficacy by iron in vitro is cell type dependent.
Topics: Aminolevulinic Acid; Cell Line; Culture Media; Heme; Humans; Iron; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2020 |
MAL-associated methyl nicotinate for topical PDT improvement.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Cell Line; Cell Survival; Humans; Male; NAD; Nicotinic Acids; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats, Wistar; Skin; Skin Diseases | 2020 |
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Optical Imaging; Photosensitizing Agents; Protoporphyrins; Surgery, Computer-Assisted | 2021 |
Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery.
Topics: 4-Chloro-7-nitrobenzofurazan; Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Cell Proliferation; Deoxyglucose; Female; Fluorescence; Glioma; Glucose; Humans; Mice; Mice, Inbred C57BL; Molecular Imaging; Monitoring, Intraoperative; Protoporphyrins; Surgery, Computer-Assisted; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid: A novel approach towards enhanced accumulation of protoporphyrin IX for photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Drug Design; Humans; Molecular Structure; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins; Structure-Activity Relationship | 2021 |
Biotin-Containing Third Generation Glucoheptoamidated Polyamidoamine Dendrimer for 5-Aminolevulinic Acid Delivery System.
Topics: Amides; Aminolevulinic Acid; Biotin; Caco-2 Cells; Cell Death; Cell Survival; Dendrimers; Drug Delivery Systems; Fluorescence; Humans; Intracellular Space; Polyamines; Proton Magnetic Resonance Spectroscopy; Protoporphyrins; Reactive Oxygen Species | 2021 |
Mass Spectrometric Analysis of the Photobleaching of Protoporphyrin IX Used in Photodynamic Diagnosis and Therapy of Cancer.
Topics: Aminolevulinic Acid; Humans; Mass Spectrometry; Neoplasms; Photobleaching; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2021 |
Improving hexaminolevulinate enabled cancer cell detection in liquid biopsy immunosensors.
Topics: Aminolevulinic Acid; Biosensing Techniques; Cell Line, Tumor; Cells, Cultured; Humans; Immunologic Tests; Liquid Biopsy; Microfluidics; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity; Urinary Bladder Neoplasms; Urothelium | 2021 |
Efficiency of aminolevulinic acid (ALA)-photodynamic therapy based on ALA uptake transporters in a cell density-dependent malignancy model.
Topics: Adaptor Proteins, Signal Transducing; Aminolevulinic Acid; Antineoplastic Agents; Biological Transport; Cell Count; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Humans; Light; Membrane Transport Proteins; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Transcription Factors; YAP-Signaling Proteins | 2021 |
Protein-aggregating ability of different protoporphyrin-IX nanostructures is dependent on their oxidation and protein-binding capacity.
Topics: Aminolevulinic Acid; Animals; Binding Sites; Cattle; Cell Line; Deferoxamine; Dimerization; Humans; Hydrogen-Ion Concentration; Models, Biological; Nanostructures; Oxidation-Reduction; Protein Aggregates; Protein Binding; Protein Structure, Secondary; Protoporphyrins; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2021 |
In Vivo Assessment of Mitochondrial Oxygen Consumption.
Topics: Aminolevulinic Acid; Animals; Body Temperature; Equipment Design; Luminescent Measurements; Mitochondria; Oxygen Consumption; Protoporphyrins; Rats, Wistar; Respiration, Artificial; Skin; Tracheotomy | 2021 |
Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Chromosome Deletion; Female; Fluorescence; Glioma; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Male; Middle Aged; Photosensitizing Agents; Positron-Emission Tomography; Protoporphyrins; Radiopharmaceuticals; Spectrometry, Fluorescence; Tyrosine | 2022 |
Experimental investigation of a combinational iron chelating protoporphyrin IX prodrug for fluorescence detection and photodynamic therapy.
Topics: Aminolevulinic Acid; Fluorescence; Humans; Iron Chelating Agents; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2022 |
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Down-Regulation; Glioblastoma; Glioma; Male; Mice; Mice, Inbred C57BL; Neoplastic Stem Cells; NF-kappa B; Photosensitizing Agents; Proto-Oncogene Proteins c-akt; Protoporphyrins; Signal Transduction; Ultrasonic Therapy | 2021 |
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Humans; Hyperparathyroidism, Secondary; Organoids; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sirolimus; Time Factors | 2021 |
REAP (Rapid Elimination of Active Plasmodium): A photodynamic strategy exploiting intrinsic kinetics of the parasite to combat severe malaria.
Topics: Aminolevulinic Acid; Antimalarials; Drug Resistance; Erythrocytes; Humans; Kinetics; Light; Malaria; Photochemotherapy; Photosensitizing Agents; Plasmodium falciparum; Protoporphyrins; Severity of Illness Index | 2021 |
Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin.
Topics: Aminolevulinic Acid; Carbazoles; Fluorescence; Humans; Light; Neoplasms; Photochemotherapy; Photosensitizing Agents; Piperidines; Protoporphyrins; Tumor Cells, Cultured | 2021 |
OPD (Online Plasmodium Diagnosis): An ALA-PpIX based functional assay to predict active malaria.
Topics: Aminolevulinic Acid; Animals; Humans; Malaria; Photochemotherapy; Photosensitizing Agents; Plasmodium; Protoporphyrins | 2021 |
Small molecule kinase inhibitors enhance aminolevulinic acid-mediated protoporphyrin IX fluorescence and PDT response in triple negative breast cancer cell lines.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Triple Negative Breast Neoplasms | 2021 |
Synthesis and photodynamic efficacy of water-soluble protoporphyrin IX homologue with mPEG550.
Topics: Aminolevulinic Acid; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectroscopy, Fourier Transform Infrared; Water | 2021 |
Photodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Gliosarcoma; Humans; Lac Operon; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2022 |
Methods to Measure the Inhibition of ABCG2 Transporter and Ferrochelatase Activity to Enhance Aminolevulinic Acid-Protoporphyrin IX Fluorescence-Guided Tumor Detection and Resection.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors; Ferrochelatase; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2022 |
First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Humans; Margins of Excision; Photosensitizing Agents; Protoporphyrins | 2022 |
Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Ferrochelatase; Fluorescence; Glioma; Humans; Lapatinib; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2022 |
Identification and pharmacological modification of resistance mechanisms to protoporphyrin-mediated photodynamic therapy in human cutaneous squamous cell carcinoma cell lines.
Topics: Aminolevulinic Acid; ATP-Binding Cassette Transporters; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms | 2022 |
Analysis of Renal Cell Carcinoma Cell Response to the Enhancement of 5-aminolevulinic Acid-mediated Protoporphyrin IX Fluorescence by Iron Chelator Deferoxamine
Topics: Aminolevulinic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Deferoxamine; Fluorescence; Heme; Humans; Iron; Iron Chelating Agents; Kidney Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2023 |
Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Hyperspectral Imaging; Photosensitizing Agents; Protoporphyrins | 2022 |
Protoporphyrin IX delayed fluorescence imaging: a modality for hypoxia-based surgical guidance.
Topics: Aminolevulinic Acid; Fluorescence; Humans; Hypoxia; Neoplasms; Oxygen; Photosensitizing Agents; Protoporphyrins | 2022 |
Desferrioxamine Enhances 5-Aminolaevulinic Acid- Induced Protoporphyrin IX Accumulation and Therapeutic Efficacy for Hypertrophic Scar.
Topics: Aminolevulinic Acid; Cicatrix, Hypertrophic; Deferoxamine; Humans; Iron Chelating Agents; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2023 |
Increased fluorescence observation intensity during the photodynamic diagnosis of deeply located tumors by fluorescence photoswitching of protoporphyrin IX.
Topics: Aminolevulinic Acid; Fluorescence; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2023 |
Combining Pr
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioblastoma; Humans; Photochemotherapy; X-Rays | 2023 |
A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin.
Topics: Aminolevulinic Acid; Animals; Cell Death; Heme; Mammals; Peroxiredoxins; Proteomics | 2023 |
Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins | 2023 |