Page last updated: 2024-09-02

protoberberine and stepholidine

protoberberine has been researched along with stepholidine in 2 studies

Compound Research Comparison

Studies (protoberberine)	Trials (protoberberine)	Recent Studies (post-2010) (protoberberine)	Studies (stepholidine)	Trials (stepholidine)	Recent Studies (post-2010) (stepholidine)
148	0	72	115	2	22

Protein Interaction Comparison

Protein	Taxonomy	stepholidine (IC50)
Tissue factor	Homo sapiens (human)	0.1046
D(2) dopamine receptor	Homo sapiens (human)	2.2427
D(1A) dopamine receptor	Homo sapiens (human)	0.0123

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lei, S; Mulvany, MJ; Orensanz, LM; Simonsen, U	1
Chen, K; Gao, B; Guo, L; Jiang, H; Li, Z; Liu, H; Qian, W; Sun, H; Yang, H; Zhen, X; Zhou, S; Zhou, Y; Zhu, L	1

Other Studies

2 other study(ies) available for protoberberine and stepholidine

Article	Year
Mechanisms involved in the vasorelaxant effect of (-)-stepholidine in rat mesenteric small arteries. European journal of pharmacology, 1999, Jan-22, Volume: 365, Issue:2-3 Topics: Animals; Berberine; Berberine Alkaloids; Calcium Channels; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Muscarinic; Serotonin	1999
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. Bioorganic & medicinal chemistry, 2013, Feb-15, Volume: 21, Issue:4 Topics: Animals; Antipsychotic Agents; Berberine; Berberine Alkaloids; CHO Cells; Cricetinae; Cricetulus; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Microwaves; Motor Activity; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship	2013

Article

Year

Mechanisms involved in the vasorelaxant effect of (-)-stepholidine in rat mesenteric small arteries.

European journal of pharmacology, 1999, Jan-22, Volume: 365, Issue:2-3

Topics: Animals; Berberine; Berberine Alkaloids; Calcium Channels; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Muscarinic; Serotonin

1999

Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.

Bioorganic & medicinal chemistry, 2013, Feb-15, Volume: 21, Issue:4

Topics: Animals; Antipsychotic Agents; Berberine; Berberine Alkaloids; CHO Cells; Cricetinae; Cricetulus; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Microwaves; Motor Activity; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

2013