protoberberine has been researched along with berberine in 41 studies
| Studies (protoberberine) | Trials (protoberberine) | Recent Studies (post-2010) (protoberberine) | Studies (berberine) | Trials (berberine) | Recent Studies (post-2010) (berberine) |
|---|---|---|---|---|---|
| 148 | 0 | 72 | 4,106 | 102 | 2,791 |
| Protein | Taxonomy | protoberberine (IC50) | berberine (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.7827 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 6.97 | |
| Cholinesterase | Homo sapiens (human) | 1.09 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.4 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 4.99 | |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | 6.71 | |
| Cholinesterase | Equus caballus (horse) | 9.4 | |
| Cytochrome P450 1B1 | Homo sapiens (human) | 0.9747 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (14.63) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 14 (34.15) | 29.6817 |
| 2010's | 14 (34.15) | 24.3611 |
| 2020's | 3 (7.32) | 2.80 |
| Authors | Studies |
|---|---|
| Ulrichová, J | 1 |
| Sethi, ML | 1 |
| Simánek, V; Ulrichová, J; Walterová, D | 1 |
| Lin, QL; Xie, PS; Yan, YZ | 1 |
| Chung, IK; Kim, JH; Kim, SA; Kwon, Y; Muller, MT | 1 |
| Lei, S; Mulvany, MJ; Orensanz, LM; Simonsen, U | 1 |
| Eom, DO; Eom, YE; Lee, HS | 1 |
| Adams, DJ; Jeong, PY; Kang, KC; Kim, JH; Kim, KY; Paik, YK; Park, KS | 1 |
| Bochoráková, H; Slanina, J; Slaninová, I; Táborská, E | 1 |
| Denier, C; Nkwengoua, E; Nyasse, B; Sondengam, B; Willson, M | 1 |
| Inada, A; Muto, N; Nakanishi, T; Ootaki, K; Shigeta, K; Tatemoto, H | 1 |
| KONDO, K; KONDO, Y; TAKEMOTO, T | 1 |
| KONDO, Y; TAKEMOTO, T | 2 |
| Brezová, V; Dvoranová, D; Kost'álová, D | 1 |
| Facchini, PJ; Park, SU; Samanani, N | 1 |
| Li, CY; Lin, CH; Lu, HJ; Wu, TS | 1 |
| Bai, LP; Cai, Z; Chen, WH; Jiang, ZH; Long, YH; Pang, JY; Qin, Y; Xu, ZL | 1 |
| Ingkaninan, K; Khorana, N; Phengpa, P; Yuenyongsawad, S | 1 |
| Kumar, GS; Maiti, M | 1 |
| Liang, X; Ren, L; Xu, Q; Xue, X; Zhang, F | 1 |
| Dostál, J; Grycová, L; Hulová, D; Kares, R; Lemière, F; Maier, L; Marek, R; Necas, M; Standara, S | 1 |
| Lu, S; Zhang, G | 1 |
| Islam, MM; Suresh Kumar, G | 1 |
| Chen, LQ; Ding, PL; Li, YG; Lu, Y | 1 |
| Liang, JQ; Lu, ZM; Tu, PF; Wang, HT; Zhang, H; Zhao, SH | 1 |
| Chen, K; Gao, B; Guo, L; Jiang, H; Li, Z; Liu, H; Qian, W; Sun, H; Yang, H; Zhen, X; Zhou, S; Zhou, Y; Zhu, L | 1 |
| Di, DL; Liu, JX; Ma, YX; Zhong, M | 1 |
| Deng, AJ; Li, ZH; Qin, HL; Wang, WJ; Wu, LQ; Yu, JQ; Zhang, HJ; Zhang, ZH | 1 |
| Bian, B; Han, L; Li, Y; Ren, W; Si, N; Wang, H; Wei, X; Xin, S; Yang, J; Zhao, H; Zuo, R | 1 |
| Bao, T; Chen, Z; Meng, J; Zhang, W | 1 |
| Bai, M; Jiang, H; Li, L; Song, F; Sun, S; Weng, Y; Zeng, S; Zhou, H; Zhou, S | 1 |
| Galanie, S; Smolke, CD | 1 |
| Chakrabarti, T; Chowdhury, SR; Jha, T; Kumar, A; Majumder, HK; Mukhopadhyay, S; Sarkar, T | 1 |
| Fukuda, M; Hosoe, T; Ishikawa, K; Sato, F; Takeda, H; Wakana, D | 1 |
| Hosoe, T; Ishikawa, K; Sato, F; Takeda, H; Wakana, D | 1 |
| Chen, YS; Huang, CC; Lee, IJ; Li, LA; Lo, SN; Ueng, YF; Wang, CW; Wu, TS | 1 |
| Bazzicalupi, C; Da Ros, S; Ferraroni, M; Gratteri, P; Papi, F; Rigo, R; Sissi, C | 1 |
| Hu, CH; Liao, GJ; Zheng, SH | 1 |
| Chen, AQ; Sun, HB; Wang, T; Wang, XZ; Wu, HL; Yan, XQ; Yu, RQ | 1 |
| Costa, EV; Costa, RA; Mary, YS; S Al-Otaibi, J; Tananta, VL | 1 |
2 review(s) available for protoberberine and berberine
| Article | Year |
|---|---|
Interaction of some enzymes with quaternary isoquinoline alkaloids.
Topics: Alkaloids; Animals; Benzophenanthridines; Berberine; Berberine Alkaloids; Brain; DNA; Duodenum; Electrophorus; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Liver; Phenanthridines; Rats; RNA | 1985 |
Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological perspectives.
Topics: Alkaloids; Aristolochic Acids; Base Pairing; Benzophenanthridines; Berberine; Berberine Alkaloids; Binding Sites; DNA; Glucosides; Isoquinolines; Nucleic Acid Conformation; RNA; Structure-Activity Relationship | 2007 |
39 other study(ies) available for protoberberine and berberine
| Article | Year |
|---|---|
Enzyme inhibition VI: Inhibition of reverse transcriptase activity by protoberberine alkaloids and structure-activity relationships.
Topics: Avian Myeloblastosis Virus; Berberine; Berberine Alkaloids; DNA; Kinetics; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 1983 |
Molecular mechanisms of the biological activity of quaternary benzophenanthridine and protoberberine alkaloids.
Topics: Alkaloids; Animals; Bacteria; Berberine; Berberine Alkaloids; Biopolymers; Drug Evaluation, Preclinical; Drug Interactions; Enzymes; Mice; Nucleic Acids; Phenanthridines; Rats | 1984 |
[Thin layer chromatographic fingerprint of Rhizomata of Coptis spp].
Topics: Berberine; Berberine Alkaloids; Chromatography, Thin Layer; Drugs, Chinese Herbal; Species Specificity | 1993 |
Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine.
Topics: Berberine; Berberine Alkaloids; Catalysis; DNA Damage; DNA Topoisomerases, Type II; DNA, Superhelical; Enzyme Activation; Etoposide; Humans; Intercalating Agents; Peptide Mapping; Plants, Medicinal; Topoisomerase II Inhibitors | 1998 |
Mechanisms involved in the vasorelaxant effect of (-)-stepholidine in rat mesenteric small arteries.
Topics: Animals; Berberine; Berberine Alkaloids; Calcium Channels; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Muscarinic; Serotonin | 1999 |
Narrowbore high performance liquid chromatography of berberine and palmatine in crude drugs and pharmaceuticals with ion-pair extraction using cobalt thiocyanate reagent.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Cobalt; Indicators and Reagents; Medicine, Chinese Traditional; Thiocyanates | 1999 |
HWY-289, a novel semi-synthetic protoberberine derivative with multiple target sites in Candida albicans.
Topics: Antifungal Agents; Berberine; Berberine Alkaloids; Candida albicans; Cell Division; Chitin Synthase; Humans; Microbial Sensitivity Tests; Sterols | 2001 |
Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells.
Topics: Alkaloids; Antioxidants; Benzophenanthridines; Berberine; Berberine Alkaloids; Cell Division; Cytoskeleton; HeLa Cells; Humans; Isoquinolines; Phenanthridines; Saccharomyces cerevisiae; Schizosaccharomyces | 2001 |
Modified berberine and protoberberines from Enantia chlorantha as potential inhibitors of Trypanosoma brucei.
Topics: Animals; Berberine; Berberine Alkaloids; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Indicators and Reagents; Phosphofructokinases; Phosphoglycerate Kinase; Plant Epidermis; Plants, Medicinal; Trypanocidal Agents; Trypanosoma brucei brucei | 2002 |
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids.
Topics: Animals; Berberine; Berberine Alkaloids; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Coptis chinensis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Nerve Growth Factors; Neurites; PC12 Cells; Rats | 2002 |
[Reactions of protoberberine-type alkaloids. III. Structure of reduced product of berberine phenolbetaine].
Topics: Alkaloids; Berberine; Berberine Alkaloids | 1963 |
[Reactions of protoberberine-type alkaloids. I. Reaction of dihydroberberine with alkylhalide].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Halogens | 1962 |
[Reactions of protoberberine-type alkaloids. IV. Synthesis of tetrahydroberberine N-Oxide].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Organic Chemicals; Oxides | 1963 |
Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium.
Topics: Berberine; Berberine Alkaloids; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Mahonia; Photochemistry; Photosensitizing Agents; Phytotherapy; Plant Extracts | 2004 |
Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis.
Topics: Berberine; Berberine Alkaloids; Cloning, Molecular; DNA, Complementary; DNA, Plant; Genes, Plant; Molecular Sequence Data; Papaver; Plant Proteins; Plant Roots; Rhizome; RNA, Plant; Species Specificity; Thalictrum; Tissue Distribution; Transcription, Genetic | 2005 |
A rapid and simple determination of protoberberine alkaloids in cortex phellodendri by 1H NMR and its application for quality control of commercial traditional Chinese medicine prescriptions.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Calibration; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Models, Chemical; Quality Control; Reproducibility of Results | 2006 |
Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA.
Topics: Berberine; Berberine Alkaloids; Dimerization; DNA | 2006 |
Acetylcholinesterase inhibitors from Stephania venosa tuber.
Topics: Acetylcholinesterase; Berberine; Berberine Alkaloids; Cholinesterase Inhibitors; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Tubers; Stephania; Structure-Activity Relationship; Thailand | 2006 |
High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs.
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis chinensis; Drugs, Chinese Herbal; Mass Spectrometry; Molecular Structure; Phellodendron | 2007 |
Covalent bonding of azoles to quaternary protoberberine alkaloids.
Topics: Alkaloids; Azoles; Berberine; Berberine Alkaloids; Chemistry, Organic; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2008 |
Alkaloids from Gendarussa vulgaris Nees.
Topics: Acanthaceae; Berberine; Berberine Alkaloids; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular | 2008 |
RNA-binding potential of protoberberine alkaloids: spectroscopic and calorimetric studies on the binding of berberine, palmatine, and coralyne to protonated RNA structures.
Topics: Berberine; Berberine Alkaloids; Biological Products; Calorimetry; Hydrogen-Ion Concentration; Nucleic Acid Conformation; Poly I-C; Protons; RNA; Spectrum Analysis; Thermodynamics | 2009 |
Determination of protoberberine alkaloids in Rhizoma Coptidis by ERETIC ¹H NMR method.
Topics: Berberine; Berberine Alkaloids; Coptis; Limit of Detection; Magnetic Resonance Spectroscopy | 2012 |
Total synthesis of epiberberine.
Topics: Berberine; Berberine Alkaloids; Catalysis; Cyclization; Molecular Structure | 2012 |
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.
Topics: Animals; Antipsychotic Agents; Berberine; Berberine Alkaloids; CHO Cells; Cricetinae; Cricetulus; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Microwaves; Motor Activity; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
A new quaternary protoberberine alkaloid isolated from Dicranostigma leptopodum (Maxim) Fedde.
Topics: Berberine; Berberine Alkaloids; Drugs, Chinese Herbal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Papaveraceae | 2014 |
New synthetic method of 8-oxocoptisine starting from natural quaternary coptisine as anti-ulcerative colitis agent.
Topics: Berberine; Berberine Alkaloids; Colitis, Ulcerative; Ferricyanides; Molecular Structure | 2014 |
Metabolic profiling analysis of berberine, palmatine, jatrorrhizine, coptisine and epiberberine in zebrafish by ultra-high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometer.
Topics: Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Metabolomics; Models, Animal; Tandem Mass Spectrometry; Zebrafish | 2015 |
Novel molecularly imprinted magnetic nanoparticles for the selective extraction of protoberberine alkaloids in herbs and rat plasma.
Topics: Administration, Oral; Adsorption; Alkaloids; Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Ferric Compounds; Hydrogen-Ion Concentration; Magnetite Nanoparticles; Nanotechnology; Phellodendron; Plant Bark; Plant Extracts; Polymers; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared | 2015 |
Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Berberine; Berberine Alkaloids; Cells, Cultured; Chromatography, Liquid; Dogs; Humans; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Octamer Transcription Factor-3; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Polymorphism, Genetic; Tandem Mass Spectrometry | 2016 |
Optimization of yeast-based production of medicinal protoberberine alkaloids.
Topics: Batch Cell Culture Techniques; Berberine; Berberine Alkaloids; Bioreactors; Biosynthetic Pathways; Cytochrome P-450 Enzyme System; Fermentation; Gene Dosage; Metabolic Engineering; Pilot Projects; Saccharomyces cerevisiae; Tetrahydropapaveroline | 2015 |
A new bisbenzylisoquinoline alkaloid isolated from Thalictrum foliolosum, as a potent inhibitor of DNA topoisomerase IB of Leishmania donovani.
Topics: Alkaloids; Animals; Antiprotozoal Agents; Berberine; Berberine Alkaloids; Cells, Cultured; DNA Topoisomerases, Type I; Isoquinolines; Leishmania donovani; Macrophages, Peritoneal; Mice, Inbred BALB C; Molecular Structure; Thalictrum; Topoisomerase I Inhibitors | 2016 |
11-Hydroxylation of Protoberberine by the Novel Berberine-Utilizing Aerobic Bacterium Sphingobium sp. Strain BD3100.
Topics: Benzoflavones; Berberine; Berberine Alkaloids; Cytochrome P-450 Enzyme Inhibitors; Hydroxylation; Japan; Microbial Sensitivity Tests; Molecular Sequence Data; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Sphingomonadaceae | 2015 |
Isolation and identification of berberine and berberrubine metabolites by berberine-utilizing bacterium Rhodococcus sp. strain BD7100.
Topics: Berberine; Berberine Alkaloids; Biotransformation; Culture Media; Phenylacetates; Rhodococcus | 2016 |
Berberine Activates Aryl Hydrocarbon Receptor but Suppresses CYP1A1 Induction through miR-21-3p Stimulation in MCF-7 Breast Cancer Cells.
Topics: Basic Helix-Loop-Helix Transcription Factors; Berberine; Berberine Alkaloids; Breast Neoplasms; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; MicroRNAs; Molecular Structure; Receptors, Aryl Hydrocarbon | 2017 |
Role of the Benzodioxole Group in the Interactions between the Natural Alkaloids Chelerythrine and Coptisine and the Human Telomeric G-Quadruplex DNA. A Multiapproach Investigation.
Topics: Alkaloids; Benzodioxoles; Benzophenanthridines; Berberine; Berberine Alkaloids; Crystallography, X-Ray; DNA; G-Quadruplexes; Humans; Isoquinolines; Ligands | 2017 |
[Biotransformation and enzymatic mechanism of protoberberine alkaloids].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Biotransformation; Coptis | 2020 |
Chemometrics-enhanced high-performance liquid chromatography-diode array detection strategy to quantify protoberberine alkaloids in varying Coptidis Rhizoma-related medicines.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chemometrics; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal | 2022 |
DFT, ADME studies and evaluation of the binding with HSA and MAO-B inhibitory potential of protoberberine alkaloids from Guatteria friesiana: theoretical insights of promising candidates for the treatment of Parkinson's disease.
Topics: Berberine; Dopamine; Guatteria; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease | 2023 |