prothionamide has been researched along with lomefloxacin* in 1 studies
1 other study(ies) available for prothionamide and lomefloxacin
| Article | Year |
|---|---|
Cytochemical Evaluation of the Toxic Effects of Combined Antituberculosis Substances on Metabolic State of Blood Lymphocytes.
Combined antituberculosis substances induced a dose-dependent changes in activity of dehydrogenases and hydrolases in rat lymphocytes. The main toxic effect of the substances was related to inhibition of mitochondrial dehydrogenases (succinate dehydrogenase and α-glycerol phosphate dehydrogenase) usually followed by suppression of activity of hydrolytic enzymes (acid phosphatase and non-specific esterase). Opposite changes in lactate dehydrogenase activity reflected specific features of intoxication. Topics: Acid Phosphatase; Administration, Oral; Animals; Animals, Outbred Strains; Antitubercular Agents; Drug Combinations; Esterases; Ethambutol; Fluoroquinolones; Gene Expression; Glycerolphosphate Dehydrogenase; Isoniazid; L-Lactate Dehydrogenase; Lymphocytes; Male; Primary Cell Culture; Prothionamide; Pyrazinamide; Rats; Rifampin; Succinate Dehydrogenase | 2020 |