Compounds > prostratin
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prostratin and bryostatin 1

prostratin has been researched along with bryostatin 1 in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's0 (0.00)29.6817
2010's5 (50.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Acs, G; Areces, LB; Blumberg, PM; Kazanietz, MG; Lewin, NE; Szallasi, Z1
Boyd, MR; Buckheit, RW; Gulakowski, RJ; Gustafson, KR; McMahon, JB1
DeChristopher, BA; Loy, BA; Marsden, MD; Schrier, AJ; Wender, PA; Zack, JA1
Bullen, CK; Durand, CM; Hill, AL; Laird, GM; Martin, AR; Rosenbloom, DI; Siliciano, JD; Siliciano, RF1
Barat, C; Dental, C; Ouellet, M; Proust, A; Tremblay, MJ1
Pande, VS; Ryckbosch, SM; Wender, PA1
Andersen, RJ; Ntie-Kang, F; Tietjen, I1
Alcami, J; Bedoya, LM; Beltrán, M; Bueno, P; Cachet, X; Camarero, S; De la Torre-Tarazona, HE; Fernández-García, JL; Jiménez, R; Litaudon, M; Nothias, LF; Paolini, J; Román, L1
Benner, NL; Chun, TW; Dimapasoc, M; Keenan, KN; Marsden, MD; Sloane, JL; Soliman, MSA; Wender, PA; Wu, X; Zack, JA; Zang, X1
Akari, H; Irie, K; Kikumori, M; Murata, M; Seki, Y; Tan, W; Tang, Y; Wardani, NP; Washizaki, A1

Reviews

2 review(s) available for prostratin and bryostatin 1

ArticleYear
Protein kinase C in signal transduction and carcinogenesis.
    Progress in clinical and biological research, 1994, Volume: 387

    Topics: 3T3 Cells; Animals; Bryostatins; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Humans; Isoenzymes; Lactones; Macrolides; Mice; Mice, Inbred C3H; Phorbol Esters; Protein Binding; Protein Kinase C; Receptors, Cell Surface; Signal Transduction; Skin Neoplasms; Structure-Activity Relationship

1994
Natural product-derived compounds in HIV suppression, remission, and eradication strategies.
    Antiviral research, 2018, Volume: 158

    Topics: Anti-HIV Agents; Biological Products; Bryostatins; Depsipeptides; Disease Reservoirs; Diterpenes; Drug Discovery; Gene Products, tat; Histone Deacetylase Inhibitors; HIV Infections; HIV-1; Humans; Phorbol Esters; rev Gene Products, Human Immunodeficiency Virus; Virus Latency; Vorinostat

2018

Other Studies

8 other study(ies) available for prostratin and bryostatin 1

ArticleYear
Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV).
    Antiviral research, 1997, Volume: 33, Issue:2

    Topics: Anti-HIV Agents; Bryostatins; CD4 Antigens; Cell Line; Cell Line, Transformed; Cytopathogenic Effect, Viral; Down-Regulation; HIV-1; Humans; Lactones; Macrolides; Phorbol Esters; Virus Replication

1997
Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro.
    Nature chemistry, 2012, Volume: 4, Issue:9

    Topics: Animals; Anti-HIV Agents; Bryostatins; Cell Line; Chemical Engineering; Drug Design; HIV; Humans; Phorbol Esters; Protein Kinase C; Rats; Virus Activation

2012
Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.
    The Journal of clinical investigation, 2015, Volume: 125, Issue:5

    Topics: Adult; Anti-HIV Agents; Azepines; Bryostatins; CD4-Positive T-Lymphocytes; Cells, Cultured; Disulfiram; Drug Evaluation, Preclinical; Drug Synergism; Female; Histone Deacetylase Inhibitors; HIV Infections; HIV-1; Humans; Lymphocyte Activation; Lymphokines; Male; Middle Aged; Phorbol Esters; Protein Kinase C; RNA, Messenger; RNA, Viral; Transcription, Genetic; Triazoles; Virion; Virus Latency

2015
HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood-Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration.
    Journal of immunology (Baltimore, Md. : 1950), 2017, 02-01, Volume: 198, Issue:3

    Topics: Acetamides; Azacitidine; Azepines; Blood-Brain Barrier; Bryostatins; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chemokine CCL2; Cytokines; Decitabine; HIV-1; Humans; Inflammation; Intercellular Adhesion Molecule-1; Leukocytes; Phorbol Esters; Quinazolines; Receptors, Cell Surface; Virus Latency

2017
Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.
    Nature communications, 2017, 02-23, Volume: 8, Issue:1

    Topics: Adjuvants, Immunologic; Antineoplastic Agents; Binding, Competitive; Bryostatins; Cell Membrane; Diglycerides; Humans; Ligands; Membrane Proteins; Molecular Dynamics Simulation; Phorbol Esters; Protein Binding; Protein Kinase C; Protein Kinase Inhibitors; Thermodynamics; Water

2017
4-Deoxyphorbol inhibits HIV-1 infection in synergism with antiretroviral drugs and reactivates viral reservoirs through PKC/MEK activation synergizing with vorinostat.
    Biochemical pharmacology, 2020, Volume: 177

    Topics: Anti-HIV Agents; Bryostatins; CD4-Positive T-Lymphocytes; Cell Survival; Drug Synergism; HIV Infections; HIV-1; Humans; Jurkat Cells; Mitogen-Activated Protein Kinase Kinases; Phorbol Esters; Protein Kinase C; Signal Transduction; Virus Activation; Virus Latency; Vorinostat

2020
Prodrugs of PKC modulators show enhanced HIV latency reversal and an expanded therapeutic window.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 05-19, Volume: 117, Issue:20

    Topics: Animals; Anti-HIV Agents; Bryostatins; Cell Line, Tumor; Cells, Cultured; Diterpenes; HIV Infections; HIV-1; Humans; Mice; Mice, Inbred C57BL; Phorbol Esters; Prodrugs; Protein Kinase C; Virus Latency

2020
The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation.
    Viruses, 2021, 10-09, Volume: 13, Issue:10

    Topics: Anti-HIV Agents; Azepines; Bryostatins; CD4-Positive T-Lymphocytes; Cell Line; HIV Infections; HIV-1; Humans; Lymphocyte Activation; Phorbol Esters; Signal Transduction; Triazoles; Virus Latency

2021