prostaglandin-d2 and tamarixetin

The aim of this study was to evaluate the inhibitory effect of tamarixetin on the production of inflammatory mediators in IgE/antigen-induced mouse bone marrow-derived mast cells (BMMCs).. The effects of tamarixetin on mast cell activation were investigated with regard to degranulation, eicosanoid generation, Ca2+ influx, and immunoblotting of various signaling molecules.. Tamarixetin effectively decreased degranulation and the eicosanoid generation such as leukotriene C. Taken together, this study suggests that tamarixetin inhibits degranulation and eicosanoid generation through the PLCγ1 as well as Akt pathways in BMMCs, which would be potential for the prevention of allergic inflammatory diseases.

Topics: Animals; beta-N-Acetylhexosaminidases; Bone Marrow Cells; Calcium; Cell Degranulation; Disaccharides; Eicosanoids; Inflammation Mediators; Inula; Leukotriene C4; Mast Cells; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phospholipases A2; Phosphorylation; Prostaglandin D2; Protein Kinases; Proto-Oncogene Proteins c-akt; Quercetin