prostaglandin-d2 and oxosorbicillinol

prostaglandin-d2 has been researched along with oxosorbicillinol* in 1 studies

Other Studies

1 other study(ies) available for prostaglandin-d2 and oxosorbicillinol

Article	Year
6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penicillium sp. Bioscience, biotechnology, and biochemistry, 2012, Volume: 76, Issue:7 A new lipoxygenase inhibitor, 6'-hydroxyoxosorbicillinol (1, C(14) H(16)O(6)), was identified from a culture of Penicillium sp. A known compound, oxosorbicillinol (2, C(14)H(16)O(5)), was also isolated. Compound 1 showed an approximately 10 times greater inhibitory effect on soybean lipoxygenase (IC(50), 16 µM) than 2 (IC(50), 150 µM), and also showed prostaglandin D(2) (PGD(2)) and leucotriene B(4) (LTB(4)) release suppression activity (IC(50), 10 µM for PGD(2) and 100 µM for LTB(4)). Topics: Animals; Basophils; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cyclohexanones; Humans; Inhibitory Concentration 50; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Penicillium; Prostaglandin D2; Rats	2012

Article

Year

6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penicillium sp.

Bioscience, biotechnology, and biochemistry, 2012, Volume: 76, Issue:7

A new lipoxygenase inhibitor, 6'-hydroxyoxosorbicillinol (1, C(14) H(16)O(6)), was identified from a culture of Penicillium sp. A known compound, oxosorbicillinol (2, C(14)H(16)O(5)), was also isolated. Compound 1 showed an approximately 10 times greater inhibitory effect on soybean lipoxygenase (IC(50), 16 µM) than 2 (IC(50), 150 µM), and also showed prostaglandin D(2) (PGD(2)) and leucotriene B(4) (LTB(4)) release suppression activity (IC(50), 10 µM for PGD(2) and 100 µM for LTB(4)).

Topics: Animals; Basophils; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cyclohexanones; Humans; Inhibitory Concentration 50; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Penicillium; Prostaglandin D2; Rats

2012