prostaglandin-d2 and mastoparan

prostaglandin-d2 has been researched along with mastoparan* in 2 studies

Other Studies

2 other study(ies) available for prostaglandin-d2 and mastoparan

Article	Year
Influence of vitamin E on mast cell mediator release. Veterinary dermatology, 2002, Volume: 13, Issue:6 We investigated the influence of vitamin E on mediator activity and release in a canine mastocytoma cell line (C2) as a model for canine atopic dermatitis. Cells were incubated without and with vitamin E (100 microm) for 24 h. The histamine and prostaglandin D2 (PGD2) release as well as the chymase and tryptase activity were measured. To stimulate the PGD2 and histamine release, cells were incubated with the wasp venom peptide mastoparan (50 microm) for 30 or 45 min. Nonstimulated as well as mastoparan-stimulated histamine and PGD2 release was reduced significantly in vitamin E-treated cells. The activity of chymase tended to decrease, but the tryptase activity of C2 cells was not influenced by vitamin E. These results indicate that vitamin E decreased the production and release of inflammatory mediators in C2 cells, suggesting that vitamin E might have a possible beneficial effect in inflammatory diseases. Topics: Animals; Cell Line; Chymases; Dermatitis, Atopic; Dog Diseases; Dogs; Histamine; Histamine Release; Intercellular Signaling Peptides and Proteins; Mast Cells; Peptides; Prostaglandin D2; Serine Endopeptidases; Tryptases; Vitamin E; Wasp Venoms	2002
Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1 Melittin stimulates glycogenolysis and induces vasoconstriction in perfused rat liver. The effect was rapid and associated with production and release of prostaglandin D2 and thromboxane B2. Indomethacin blocked the release of these eicosanoids and the stimulation of glycogenolysis induced by melittin. Ibuprofen blocked the release of prostaglandin D2 induced by melittin and markedly attenuated that of thromboxane B2. Interestingly, the initial burst of glucose output induced by melittin was not inhibited by ibuprofen, although the duration of the glycogenolytic action of the peptide was greatly diminished. Topics: Animals; Bee Venoms; Female; Glycogen; Ibuprofen; Indomethacin; Intercellular Signaling Peptides and Proteins; Kinetics; Liver; Melitten; Peptides; Prostaglandin D2; Rats; Rats, Inbred Strains; Thromboxane B2; Vasoconstriction; Wasp Venoms	1990

Article

Year

Influence of vitamin E on mast cell mediator release.

Veterinary dermatology, 2002, Volume: 13, Issue:6

We investigated the influence of vitamin E on mediator activity and release in a canine mastocytoma cell line (C2) as a model for canine atopic dermatitis. Cells were incubated without and with vitamin E (100 microm) for 24 h. The histamine and prostaglandin D2 (PGD2) release as well as the chymase and tryptase activity were measured. To stimulate the PGD2 and histamine release, cells were incubated with the wasp venom peptide mastoparan (50 microm) for 30 or 45 min. Nonstimulated as well as mastoparan-stimulated histamine and PGD2 release was reduced significantly in vitamin E-treated cells. The activity of chymase tended to decrease, but the tryptase activity of C2 cells was not influenced by vitamin E. These results indicate that vitamin E decreased the production and release of inflammatory mediators in C2 cells, suggesting that vitamin E might have a possible beneficial effect in inflammatory diseases.

Topics: Animals; Cell Line; Chymases; Dermatitis, Atopic; Dog Diseases; Dogs; Histamine; Histamine Release; Intercellular Signaling Peptides and Proteins; Mast Cells; Peptides; Prostaglandin D2; Serine Endopeptidases; Tryptases; Vitamin E; Wasp Venoms

2002

Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2.

The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1

Melittin stimulates glycogenolysis and induces vasoconstriction in perfused rat liver. The effect was rapid and associated with production and release of prostaglandin D2 and thromboxane B2. Indomethacin blocked the release of these eicosanoids and the stimulation of glycogenolysis induced by melittin. Ibuprofen blocked the release of prostaglandin D2 induced by melittin and markedly attenuated that of thromboxane B2. Interestingly, the initial burst of glucose output induced by melittin was not inhibited by ibuprofen, although the duration of the glycogenolytic action of the peptide was greatly diminished.

Topics: Animals; Bee Venoms; Female; Glycogen; Ibuprofen; Indomethacin; Intercellular Signaling Peptides and Proteins; Kinetics; Liver; Melitten; Peptides; Prostaglandin D2; Rats; Rats, Inbred Strains; Thromboxane B2; Vasoconstriction; Wasp Venoms

1990