prostaglandin-d2 has been researched along with brazilin* in 1 studies
1 other study(ies) available for prostaglandin-d2 and brazilin
| Article | Year |
|---|---|
Effects of Brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets.
Brazilin (7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6 H)-tetrol) inhibited thrombin-,collagen- and ADP-induced aggregation of washed rat platelets. Thrombin- and collagen-induced ATP release were also inhibited by brazilin in a concentration-dependent manner. Brazilin inhibited the formation of platelet thromboxane A2 caused by thrombin, whereas it had no effect on the prostaglandin D2 formation. Brazilin inhibited [3H]-arachidonic acid liberation from membrane phospholipids of thrombin-stimulated platelets. Brazilin inhibited the rise of intracellular free calcium caused by thrombin. These results indicate that the inhibition of phospholipase (PLA2) activity and [Ca2+]i elevation might be at least a part of antiplatelet mechanism of brazilin. Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Benzopyrans; Blood Platelets; Calcium; Female; In Vitro Techniques; Phospholipases A; Phospholipases A2; Platelet Aggregation; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 1998 |