prostaglandin-d2 has been researched along with 2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline* in 1 studies
1 other study(ies) available for prostaglandin-d2 and 2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
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Structural and interaction analysis of human lipocalin-type prostaglandin D synthase with the poorly water-soluble drug NBQX.
Lipocalin-type prostaglandin D synthase (L-PGDS) is a secretory lipid-transporter protein that was shown to bind a wide variety of hydrophobic ligands in vitro. Exploiting this function, we previously examined the feasibility of using L-PGDS as a novel delivery vehicle for poorly water-soluble drugs. However, the mechanism by which human L-PGDS binds to poorly water-soluble drugs is unclear. In this study, we determined the solution structure of human L-PGDS and investigated the mechanism of L-PGDS binding to 6-nitro-7-sulfamoyl-benzo[f]quinoxalin-2,3-dione (NBQX), an α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist. NMR experiments showed that human L-PGDS has an eight-stranded antiparallel β-barrel structure that forms a central cavity, a short 3 Topics: Humans; Lipocalins; Molecular Docking Simulation; Pharmaceutical Preparations; Prostaglandin D2; Protein Binding; Water | 2023 |