prostaglandin-a2 and fentiazac

Prostaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels. Removal of adherent cells from mononuclear cell populations also resulted in enhanced IL-2 production. The resultant nonadherent cell population lost sensitivity to the enhancement effect of PG synthetase inhibitors, suggesting that a PGE-producing adherent cell plays a major role in the regulation of IL-2.

Topics: Acetates; Alprostadil; Cell Adhesion; Dinoprost; Dinoprostone; Female; Humans; Indomethacin; Interleukin-2; Lymphokines; Male; Prostaglandins A; Prostaglandins E; Prostaglandins F; Thiazoles