Compounds > prorenone
Page last updated: 2024-09-05

prorenone and spironolactone

prorenone has been researched along with spironolactone in 9 studies

Compound Research Comparison

Studies
(prorenone)		Trials
(prorenone)		Recent Studies (post-2010)
(prorenone)		Studies
(spironolactone)		Trials
(spironolactone)		Recent Studies (post-2010) (spironolactone)
9007,2229601,923

Protein Interaction Comparison

ProteinTaxonomyprorenone (IC50)spironolactone (IC50)
Chain A, Mineralocorticoid receptorHomo sapiens (human)0.049
Chain A, Mineralocorticoid receptorHomo sapiens (human)0.049
Estrogen receptorHomo sapiens (human)5.702
Glucocorticoid receptorHomo sapiens (human)4.0745
Progesterone receptorHomo sapiens (human)1.675
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)1.9025
Mineralocorticoid receptor Homo sapiens (human)0.0315
Androgen receptorHomo sapiens (human)0.3585
Androgen receptorRattus norvegicus (Norway rat)0.406
Glycine receptor subunit betaRattus norvegicus (Norway rat)1.9025
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)1.9025
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)1.9025
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)6.92
Cytochrome P450 2C19Homo sapiens (human)3

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19909 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Claire, M; Corvol, P; Michaud, A; Rafestin-Oblin, ME; Roth-Meyer, C1
Emadian, SM; Luttge, WG1
Biollaz, M; de Gasparo, M; Grob, J; Haenni, H; Joss, U; Kraehenbuehl, C; Ramjoué, HP; Schenkel, L; Schmidlin, J; Whitebread, SE1
Capron, MH; Delarue, C; Leboulenger, F; Netchitailo, P; Perroteau, I; Vaudry, H2
Gomez-Sanchez, EP1
Claire, M; Corvol, P; Gäggeler, HP; Geering, K; Rafestin-Oblin, ME; Rossier, BC1
Clarke, JM; Harrison, IR; McInnes, GT; Perkins, RM; Shelton, JR1
Claire, M; Corvol, P; Geering, K; Oblin, ME; Rossier, B1

Reviews

1 review(s) available for prorenone and spironolactone

ArticleYear
Mechanism of the antimineralocorticoid effects of spirolactones.
    Kidney international, 1981, Volume: 20, Issue:1

    Topics: Aldosterone; Animals; Anura; Canrenoic Acid; Canrenone; Cattle; Guinea Pigs; Humans; Male; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Steroid; Spironolactone; Veratrum Alkaloids

1981

Other Studies

8 other study(ies) available for prorenone and spironolactone

ArticleYear
Mechanism of action of a new antialdosterone compound, prorenone.
    Endocrinology, 1979, Volume: 104, Issue:4

    Topics: Aldosterone; Animals; Binding, Competitive; Cell Nucleus; Dexamethasone; Dihydrotestosterone; Kidney; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Prostate; Rats; Receptors, Androgen; Receptors, Glucocorticoid; Spironolactone

1979
Further chemical differentiation of type I and type II adrenocorticosteroid receptors in mouse brain cytosol: evidence for a new class of glucocorticoid receptors.
    Brain research, 1988, Jun-21, Volume: 453, Issue:1-2

    Topics: Aldosterone; Androstanols; Animals; Brain Chemistry; Cytosol; Dextrans; Dithionitrobenzoic Acid; Female; Mice; Potassium Chloride; Receptors, Glucocorticoid; Spironolactone; Subcellular Fractions

1988
Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2

    Topics: Androgen Antagonists; Animals; Biological Assay; Epoxy Compounds; Female; Male; Mineralocorticoid Receptor Antagonists; Organ Size; Ovulation; Rabbits; Rats; Receptors, Androgen; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Progesterone; Spironolactone; Testis; Water-Electrolyte Balance

1987
Relative inhibitory potency of five mineralocorticoid antagonists on aldosterone biosynthesis in vitro.
    Biochemical pharmacology, 1985, Jan-15, Volume: 34, Issue:2

    Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Pregnenes; Ranidae; Spironolactone; Structure-Activity Relationship; Veratrum Alkaloids

1985
Intracerebroventricular infusion of aldosterone induces hypertension in rats.
    Endocrinology, 1986, Volume: 118, Issue:2

    Topics: Aldosterone; Animals; Brain; Cerebral Ventricles; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Spironolactone

1986
Binding and antimineralocorticoid activities of spirolactones in toad bladder.
    The American journal of physiology, 1983, Volume: 244, Issue:1

    Topics: Aldosterone; Animals; Binding, Competitive; Biological Transport; Bufo marinus; Female; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Steroid; Sodium; Spironolactone; Urinary Bladder

1983
[Direct action of mineralocorticoid antagonists on biosynthesis of aldosterone: comparative activities of several new compounds].
    Canadian journal of physiology and pharmacology, 1983, Volume: 61, Issue:1

    Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Pregnenes; Ranidae; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Veratrum Alkaloids

1983
Relative potency of prorenoate potassium and spironolactone in attenuating diuretic induced hypokalaemia.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:2

    Topics: Adult; Canrenone; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Metolazone; Mineralocorticoid Receptor Antagonists; Potassium; Spironolactone

1984