propylthiouracil has been researched along with isoquercitrin* in 1 studies
1 other study(ies) available for propylthiouracil and isoquercitrin
| Article | Year |
|---|---|
Ameliorating effect of postweaning exposure to antioxidant on disruption of hippocampal neurogenesis induced by developmental hypothyroidism in rats.
Developmental hypothyroidism as a model of autism spectrum disorders disrupts hippocampal neurogenesis through the adult stage. The present study investigated the ameliorating effect of postweaning exposure to antioxidant on the hypothyroidism-induced disruptive neurogenesis. Mated female Sprague-Dawley rats were treated with 0 or 10 ppm 6-propyl-2-thiouracil (PTU) as an anti-thyroid agent in drinking water from gestational day 6 to postnatal day (PND) 21 on weaning. PTU-exposed male offspring were fed either basal diet, diet containing α-glycosyl isoquercitrin (AGIQ) at 5,000 ppm or α-lipoic acid (ALA) at 1,000 ppm as an antioxidant from PND 21 to PND 77. PTU-exposure decreased DCX Topics: Animals; Antioxidants; Apoptosis; Doublecortin Protein; Female; Gene Expression Regulation, Developmental; Hippocampus; Hypothyroidism; Male; Neurogenesis; Pregnancy; Propylthiouracil; Quercetin; Rats, Sprague-Dawley; Thioctic Acid | 2019 |