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propranolol glucuronide and propranolol

propranolol glucuronide has been researched along with propranolol in 13 studies

Compound Research Comparison

Studies
(propranolol glucuronide)
Trials
(propranolol glucuronide)
Recent Studies (post-2010)
(propranolol glucuronide)
Studies
(propranolol)
Trials
(propranolol)
Recent Studies (post-2010) (propranolol)
162033,3103,4063,218

Protein Interaction Comparison

ProteinTaxonomypropranolol glucuronide (IC50)propranolol (IC50)
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)0.0347
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)2.294
Cytochrome P450 1A2Homo sapiens (human)4
Beta-2 adrenergic receptorHomo sapiens (human)0.0114
Beta-1 adrenergic receptorHomo sapiens (human)0.0575
5-hydroxytryptamine receptor 1AHomo sapiens (human)3.9811
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.012
Cytochrome P450 2D6Homo sapiens (human)2.9706
Beta-3 adrenergic receptorHomo sapiens (human)0.0493
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0288
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0827
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0288
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.012
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.466
5-hydroxytryptamine receptor 2CHomo sapiens (human)2.294
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.243
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0288
Sodium-dependent serotonin transporterHomo sapiens (human)0.38
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.342
5-hydroxytryptamine receptor 6Homo sapiens (human)3.065
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.017
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0288
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.828
Sodium channel protein type 5 subunit alphaHomo sapiens (human)2.1
Sodium/bile acid cotransporterHomo sapiens (human)5.5
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0288
GABA theta subunitRattus norvegicus (Norway rat)0.0288
Sigma non-opioid intracellular receptor 1Homo sapiens (human)2.87
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0288

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19906 (46.15)18.7374
1990's3 (23.08)18.2507
2000's4 (30.77)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Conradi, EC; Fagan, TC; Gaffney, TE; Walle, T; Walle, UK1
Ebihara, A; Fujimura, A; Ohashi, K; Tateishi, T1
Belolipetskaja, VG; Metelitsa, VI; Pavlinov, SA; Piotrovskii, VK1
Conradi, EC; Cowart, TD; Gaffney, TE; Walle, T; Walle, UK1
Effeney, DJ; Lo, MW; Pond, SM; Riegelman, S; Silber, BM; Tozer, TN1
Baker, JP; Knapp, DR; McCarthy, JR; Oatis, JE1
Eadie, MJ; Hooper, WD; Livingstone, I; Smith, MT; Triggs, EJ1
Claude, JR; Ellouk-Achard, S; Fompeydie, D; Galons, H; Gramond, JP; Levresse, V; Pham-Huy, C; Saada, V; Sahui-Gnassi, A1
Conradi, EC; Mathur, RS; Palesch, YY; Walle, K; Walle, T1
Luan, LJ; Shao, Q; Zeng, S; Zhang, XH1
Luan, L; Shao, Q; Yu, L; Zeng, S1
Luan, LJ; Ma, JY; Shao, Q; Zeng, S1
Bondesson, U; Hedeland, M; Lampinen Salomonsson, M1

Trials

2 trial(s) available for propranolol glucuronide and propranolol

ArticleYear
The influence of diltiazem versus cimetidine on propranolol metabolism.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:12

    Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Diltiazem; Half-Life; Humans; Lactates; Male; Premedication; Propranolol

1992
Stereoselective urinary excretion of S-(-)- and R-(+)-propranolol glucuronide following oral administration of RS-propranolol in Chinese Han subjects.
    World journal of gastroenterology, 2005, Mar-28, Volume: 11, Issue:12

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Asian People; Humans; Propranolol; Stereoisomerism

2005

Other Studies

11 other study(ies) available for propranolol glucuronide and propranolol

ArticleYear
Propranolol glucuronide cumulation during long-term propranolol therapy: a proposed storage mechanism for propranolol.
    Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Animals; Bile; Dogs; Glucuronates; Half-Life; Humans; Middle Aged; Propranolol

1979
Ion-exchange high-performance liquid chromatography in drug assay in biological fluids. V. Propranolol and metabolites.
    Journal of chromatography, 1989, Jul-21, Volume: 491, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Mass Spectrometry; Propranolol

1989
Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3

    Topics: Adult; Creatinine; Half-Life; Humans; Kidney; Lactates; Male; Metabolic Clearance Rate; Propranolol; Smoking

1987
Nonlinear formation of propranolol metabolites in dogs after portacaval transpositions.
    Journal of pharmacokinetics and biopharmaceutics, 1984, Volume: 12, Issue:4

    Topics: Animals; Dogs; Kinetics; Lactates; Liver; Male; Mathematics; Metabolic Clearance Rate; Portacaval Shunt, Surgical; Propranolol; Time Factors

1984
Synthesis and chromatographic separation of the glucuronides of (R)- and (S)-propranolol.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:12

    Topics: Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Propranolol; Stereoisomerism

1983
Propranolol, propranolol glucuronide, and naphthoxylactic acid in breast milk and plasma.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:1

    Topics: Female; Half-Life; Humans; Hydrogen-Ion Concentration; Lactates; Milk, Human; Pregnancy; Propranolol

1983
Microassay of propranolol enantiomers and conjugates in human plasma and urine by high-performance liquid chromatography after chiral derivatization for pharmacokinetic study.
    Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:9

    Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Male; Propranolol; Reference Standards; Stereoisomerism

1994
Propranolol metabolism in normal subjects: association with sex steroid hormones.
    Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:2

    Topics: Adult; Chromatography, High Pressure Liquid; Estradiol; Female; Humans; Lactates; Male; Metabolic Clearance Rate; Oxidation-Reduction; Propranolol; Sex Characteristics; Testosterone

1994
[Effects of microsome enzyme induced by phenobarbarbital on the stereoselectivity of recemic propranolol glucuronidation metabolism].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:1

    Topics: Animals; Enzyme Induction; Microsomes, Liver; Phenobarbital; Propranolol; Rats; Rats, Sprague-Dawley; Stereoisomerism

2004
Direct determination of S-(-)- and R-(+)-propranolol glucuronide in rat hepatic microsomes by RP-HPLC.
    Biomedical chromatography : BMC, 2004, Volume: 18, Issue:10

    Topics: Adrenergic beta-Antagonists; Animals; Chromatography, High Pressure Liquid; Male; Microsomes, Liver; Propranolol; Quality Control; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Stereoisomerism

2004
In vitro formation of phase I and II metabolites of propranolol and determination of their structures using chemical derivatization and liquid chromatography-tandem mass spectrometry.
    Journal of mass spectrometry : JMS, 2009, Volume: 44, Issue:5

    Topics: Animals; Chromatography, Liquid; Humans; Imidazoles; Male; Microsomes, Liver; Models, Chemical; Propranolol; Rats; Sulfones; Tandem Mass Spectrometry

2009