propranolol has been researched along with warfarin in 120 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (33.33) | 18.7374 |
| 1990's | 15 (12.50) | 18.2507 |
| 2000's | 29 (24.17) | 29.6817 |
| 2010's | 33 (27.50) | 24.3611 |
| 2020's | 3 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Gubernator, K; Kansy, M; Senner, F | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Hwang, KK; Mandagere, AK; Thompson, TN | 1 |
| Caron, G; Ermondi, G | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Chen, M; Cui, P; Macdonald, TL; Nadler, JL | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Briand, X; Faller, B; Lázaro, E; Lowe, PJ | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Chae, CH; Jeong, HC; Jung, YS; Kassa, J; Kuca, K; Musilek, K; Park, NJ | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Choi, SH; Kazantsev, AG; Khanfar, MA; Quinti, L; Silverman, RB; Wang, H | 1 |
| Cai, Y; Cui, W; Feng, LJ; Huang, M; Ke, H; Li, Z; Liu, P; Luo, HB; Shao, YX; Wan, Y; Wu, Y; Zhu, X | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Barnard, L; Birkholtz, LM; Botha, M; Brunschwig, C; Burrows, JN; Chibale, K; Churchyard, A; Coetzer, TL; Denti, P; Egan, TJ; Laing, L; Lauterbach, S; Machado, M; Ndubi, F; Njogu, PM; Njoroge, M; Nondaba, S; Okombo, J; Prudêncio, M; Reader, J; Singh, K; Wiesner, L; Wilkinson, C; Wittlin, S; Yeates, C | 1 |
| Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Chibale, K; Egan, TJ; Hunter, R; Joshi, MC; Ndove, J; Nsumiwa, S; Okombo, J; Taylor, D; Wiesner, L | 1 |
| Cescon, DW; Hansen, MD; Hoj, JP; Siddiqui-Jain, A | 1 |
| Azas, N; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Courtioux, B; Fairlamb, A; Hutter, S; Laget, M; Moreau, A; Mothes, E; Paloque, L; Pedron, J; Pratviel, G; Sournia-Saquet, A; Stigliani, JL; Valentin, A; Vendier, L; Verhaeghe, P; Wyllie, S | 1 |
| Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
| Abadi, AH; Abdel-Halim, M; Engel, M; Fathalla, RK; Hammam, MA; Hartmann, RW; Hefnawy, A; Keeton, AB; Maher, A; Maxuitenko, Y; Piazza, GA; Racheed, NAS; Sigler, S | 1 |
| Furukawa, K; Gotho, Y; Kubota, M | 1 |
| Koike, H; Nakayama, K; Oshima, T | 2 |
| Kunath, B; Nitz, RE; Scholtholt, J; Sirbulescu, R | 1 |
| Cotham, RH; Shand, DG; Wilkinson, GR | 1 |
| Humphries, TJ | 1 |
| Boddy, AV; Levy, RH | 1 |
| Tucker, GT | 1 |
| Chen, Z; Duan, X | 1 |
| Adedoyin, A; Wilkinson, GR; Zhou, HH | 1 |
| Barbey, JT; Schwartz, SL; Siddoway, LA; Woosley, RL | 1 |
| Hussain, AS; Ritschel, WA; Sabouni, A | 1 |
| Alván, G | 1 |
| Armstrong, DW; Armstrong, RD; Beesley, TE; Ward, TJ | 1 |
| Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y | 1 |
| Dale, O; Nilsen, OG | 1 |
| Chiba, S; Hashimoto, K; Kubota, K; Taira, N | 1 |
| Iriuchijima, J; Numao, Y | 1 |
| Carroll, RJ; Falsetti, HL; Heinle, RA; Oliveros, RA; Ryan, GF | 1 |
| Junge-Hülsing, G; Schmitt, G; Wagner, H | 1 |
| Bollinger, A | 1 |
| Koyama, T; Marutani, Y; Nakagawa, K | 1 |
| Adamska-Dyniewska, H; Goch, JH | 1 |
| Azarnoff, DL | 1 |
| Hefner, MA; Howe, BB; Winbury, MM | 1 |
| DeSanctis, RW; Hutter, AM; Krauss, KR | 1 |
| Lozinskiĭ, LG; Votchal, BE | 1 |
| Ito, K; Koike, H; Miyamoto, M; Nishino, H | 1 |
| Bax, ND; Lennard, MS; Malia, RG; Porter, NR; Preston, FE; Tucker, GT; Woods, HF | 2 |
| Feely, J | 1 |
| Luczynska, C; Wilson, K | 1 |
| Breckenridge, AM; Park, BK; Scott, AK | 2 |
| Hanano, M; Iga, T; Kawasaki, S; Sawada, Y; Sugiyama, Y; Yanagida, M; Yoshikawa, T | 1 |
| Müller, FO; Steyn, JM | 1 |
| Khouw, V; Naranjo, CA; Sandor, P; Sellers, EM | 1 |
| Khouw, V; Naranjo, CA; Sellers, EM | 1 |
| Albengres, E; Tillement, JP; Urien, S; Zini, R | 1 |
| Fernandez, L; Saunderson, H | 1 |
| Abel, JG; Cormode, EJ; Frohlich, J; Pudek, MR; Sellers, EM | 1 |
| Babb, RR | 1 |
| Hintze, KL; Levy, G; Slattery, JT; Wiegand, UW | 1 |
| Fawaz, G; Simaan, J | 1 |
| Brée, F; Carrupt, PA; Giroud, Y; Testa, B; Tillement, JP; Tsai, RS; Urien, S | 1 |
| Obach, RS | 1 |
| Humphreys, WG; Morrison, RA; Obermeier, MT | 1 |
| Ottiger, C; Wunderli-Allenspach, H | 1 |
| Greenfield, DS; Liebmann, JM; Ritch, R | 1 |
| Crespi, CL; Davitt, CM; Hu, M; Huang, SM; Li, Y; Penman, BW; Thummel, K | 1 |
| Hedeland, M; Holmin, S; Nygård, M; Pettersson, C | 1 |
| Haginaka, J; Matsunaga, H | 1 |
| Kobayashi, S; Kurata, N; Matsushita, S; Nishi, K; Otagiri, M; Suenaga, A; Watanabe, HH | 1 |
| Owens, PK; Svensson, LA | 1 |
| Alpstäg-Wöhrle, AL; Christen, B; Krämer, SD; Marenchino, M; Wunderli-Allenspach, H | 1 |
| Galeffi, C; Nicoletti, M; Palazzino, G; Rakotondramanana, DA; Ramanitrahasimbola, D; Randriantsoa, A; Rasoanaivo, P; Ratsimamanga, S | 1 |
| Balani, SK; Gallegos, R; Gan, LS; Li, P; Lu, C; Miwa, GT; Uttamsingh, V; Xia, CQ | 1 |
| Oliveira, D; Tran, CD | 1 |
| Deryabina, MA; Hansen, SH; Jensen, H | 1 |
| de Ruiter, A; Hritz, J; Oostenbrink, C | 1 |
| Arnell, R; Fornstedt, T; Samuelsson, J; Sandblad, P | 1 |
| Bielejewska, A; Bylina, A; Duszczyk, K; Fiałkowski, M; Hołyst, R | 1 |
| Müllers, KC; Pinto, JF; Wahl, MA | 2 |
| Ageno, W; Dentali, F; Squizzato, A | 1 |
| Hersh, EV; Moore, PA | 1 |
| Baumruk, V; Ettrich, R; Hofbauerová, K; Kopecký, V; Pazderka, T; Řeha, D | 1 |
| Anguizola, J; Bi, C; Hage, DS; Jackson, A; Koke, M | 1 |
| Bi, C; Clarke, W; Hage, DS; Isingizwe, Z; Matsuda, R; Zhang, C | 1 |
| Eledrisi, MS; Husnain, MG; Mushtaq, K; Rehman, A | 1 |
| Jongcherdchootrakul, K; Lertwanichwattana, T; Mungthin, M; Nilwaranon, A; Sombat, B; Tongkaew, S | 1 |
10 review(s) available for propranolol and warfarin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole.
Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin | 1991 |
Stereoselectivity in pharmacokinetics: a general theory.
Topics: Humans; Mephenytoin; Models, Biological; Pharmacokinetics; Propranolol; Stereoisomerism; Verapamil; Warfarin | 1991 |
A clinical pharmacologist's perspective.
Topics: Animals; Humans; Ibuprofen; Pharmacokinetics; Propranolol; Stereoisomerism; Structure-Activity Relationship; Warfarin | 1991 |
Clinical pharmacokinetics of moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin | 1990 |
Ethnic differences in reactions to drugs and xenobiotics. Other protein variants with pharmacogenetic consequences: albumin and orosomucoid.
Topics: Antipyrine; Binding Sites; Humans; Metabolic Clearance Rate; Metabolism, Inborn Errors; Orosomucoid; Pharmaceutical Preparations; Phenotype; Polymorphism, Genetic; Propranolol; Protein Binding; Serum Albumin; Warfarin | 1986 |
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats.
Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin | 1985 |
Interaction of cimetidine with other drugs.
Topics: Aged; Chlormethiazole; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Lidocaine; Liver; Liver Circulation; Phenytoin; Propranolol; Tissue Distribution; Warfarin | 1983 |
The clinical significance of the effects of cigarette smoking on drug disposition.
Topics: Acetaminophen; Antipyrine; Benzodiazepines; Chlorpromazine; Clomipramine; Codeine; Humans; Pharmaceutical Preparations; Phenacetin; Propranolol; Smoking; Theophylline; Warfarin | 1983 |
Three Serious Drug Interactions that Every Dentist Should Know About.
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Bradycardia; Cytochrome P-450 CYP2C9; Dental Care; Drug Interactions; Epinephrine; Fluconazole; Hemorrhage; Humans; International Normalized Ratio; Lithium; Metronidazole; Propranolol; Warfarin | 2015 |
2 trial(s) available for propranolol and warfarin
| Article | Year |
|---|---|
Clinical pharmacokinetics of moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug Interactions; Humans; Moricizine; Phenothiazines; Propranolol; Theophylline; Warfarin | 1990 |
[Determination of effort tolerance in coronary patients after Intencordin and propranolol administration].
Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Coumarins; Diethylamines; Electrocardiography; Exercise Test; Glycolates; Heart; Humans; Middle Aged; Placebos; Propranolol; Vasodilator Agents | 1973 |
109 other study(ies) available for propranolol and warfarin
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes, Liver; Models, Biological; Permeability; Pharmacokinetics; Rats; Species Specificity | 2002 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes.
Topics: Animals; Apoptosis; Cell Line; Chemoprevention; Cytokines; Diabetes Mellitus, Type 1; Drug Evaluation, Preclinical; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Molecular Structure; Pentoxifylline; Stereoisomerism | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.
Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Halogenation; Humans; Oximes; Paraoxon; Pyridinium Compounds | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Topics: Acetylation; Benzamides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Neuroprotective Agents; Sirtuin 2; Structure-Activity Relationship | 2014 |
Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blotting, Western; Body Fluids; Catalytic Domain; Crystallography, X-Ray; Drug Discovery; Gene Expression Regulation, Neoplastic; Glucose-6-Phosphatase; Hep G2 Cells; Humans; Hydrogen Bonding; Hypoglycemic Agents; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidinones; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship; Tissue Distribution | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Topics: Animals; Antimalarials; Benzimidazoles; Life Cycle Stages; Malaria; Male; Mice; Plasmodium berghei; Structure-Activity Relationship | 2017 |
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles | 2017 |
4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.
Topics: Administration, Oral; Aminopyridines; Aminoquinolines; Animals; Antimalarials; Cell Membrane Permeability; Chloroquine; CHO Cells; Cricetulus; Drug Evaluation, Preclinical; Drug Resistance, Microbial; ERG1 Potassium Channel; Hemeproteins; Humans; Malaria; Male; Mice, Inbred BALB C; Plasmodium berghei; Plasmodium falciparum; Solubility; Structure-Activity Relationship | 2017 |
Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization.
Topics: Amides; Animals; Cell Line, Tumor; Cell Proliferation; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Microsomes, Liver; Microtubules; Molecular Structure; Neoplasms, Experimental; Polymerization; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship | 2018 |
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.
Topics: Antiprotozoal Agents; Cell Survival; Dose-Response Relationship, Drug; Electrochemical Techniques; Hep G2 Cells; Humans; Kinetoplastida; Leishmania infantum; Molecular Structure; Nitroquinolines; Nitroreductases; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanosoma brucei brucei | 2018 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Topics: Animals; Blood Proteins; Celecoxib; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Female; Half-Life; Humans; Isoenzymes; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phosphodiesterase 5 Inhibitors; Protein Binding; Pyrazoles; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 2021 |
[Cardiovascular effects of propanolol, alprenolol, oxprenolol and CS-359 during halothane anesthesia (author's transl)].
Topics: Adrenergic beta-Antagonists; Alprenolol; Anesthesia, Inhalation; Animals; Coumarins; Dogs; Halothane; Hemodynamics; Humans; Oxprenolol; Propanolamines; Propranolol | 1979 |
Antiarrhythmic activity of dextro- and levo-isomers of 5-methyl-8-(2-hydroxy-3-t-butylamino-propoxy) coumarin hydrocholoride (bucumolol), a beta-adrenergic blocking agent, on aconitine-induced atrial and ouabain-induced ventricular arrhythmias in dogs.
Topics: Aconitine; Aconitum; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Anura; Arrhythmias, Cardiac; Coumarins; Dogs; Female; Guinea Pigs; Heart Atria; Heart Rate; Heart Ventricles; In Vitro Techniques; Isoproterenol; Male; Ouabain; Propanolamines; Propranolol; Quinidine; Refractory Period, Electrophysiological; Stereoisomerism; Stimulation, Chemical; Structure-Activity Relationship | 1979 |
[The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)].
Topics: Animals; Blood Pressure; Chromonar; Coronary Circulation; Coronary Disease; Coumarins; Disease Models, Animal; Dogs; Electrocardiography; Female; Heart; Heart Rate; Isoproterenol; Male; Nitroglycerin; Pacemaker, Artificial; Propranolol | 1976 |
Perfusion-limited of plasma drug binding on hepatic drug extraction.
Topics: Animals; Carrier Proteins; In Vitro Techniques; Liver; Male; Metabolic Clearance Rate; Models, Biological; Phenytoin; Propranolol; Rats; Warfarin | 1976 |
[Mechanism of the antiasthmatic effect of total coumarins in the fruit of Cnidium monnieri (L.)Cuss].
Topics: Animals; Asthma; Blood Pressure; Coumarins; Drugs, Chinese Herbal; Female; Guinea Pigs; Heart Rate; Histamine Antagonists; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Propranolol; Rats | 1990 |
Differences in plasma binding of drugs between Caucasians and Chinese subjects.
Topics: Asian People; Blood Proteins; China; Diazepam; Diphenhydramine; Disopyramide; Humans; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Salicylates; Serum Albumin; United States; Warfarin; White People | 1990 |
Percutaneous absorption of coumarin, griseofulvin and propranolol across human scalp and abdominal skin.
Topics: Abdomen; Coumarins; Griseofulvin; Humans; In Vitro Techniques; Propranolol; Scalp; Skin Absorption | 1989 |
Separation of drug stereoisomers by the formation of beta-cyclodextrin inclusion complexes.
Topics: beta-Cyclodextrins; Chemical Phenomena; Chemistry; Cinchona Alkaloids; Cyclodextrins; Dextrins; Propranolol; Starch; Stereoisomerism; Warfarin | 1986 |
Binding and distribution of restrictively and non-restrictively eliminated drugs to serum and liver cell cytosol: effects of volatile anaesthetics.
Topics: Adult; Animals; Binding Sites; Cytosol; Diazepam; Enflurane; Halothane; Humans; Kinetics; Liver; Male; Phenytoin; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Trifluoroacetic Acid; Warfarin | 1986 |
Comparison of -adrenergic blocking activity of eight blockers in the excised and blood-perfused canine sino-atrial node preparation.
Topics: Adrenergic beta-Antagonists; Amino Alcohols; Animals; Coumarins; Dogs; Heart Rate; In Vitro Techniques; Nitriles; Norepinephrine; Propranolol; Sinoatrial Node; Sotalol | 1972 |
Effects of alpha and beta blockers on hemodynamics of SHR.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiac Output; Coumarins; Heart Rate; Hemodynamics; Hypertension; Phenoxybenzamine; Propanolamines; Propranolol; Vascular Resistance | 1974 |
Atherosclerotic coronary artery aneurysm. Report of five cases and review of literature.
Topics: Adult; Aneurysm; Blood Vessel Prosthesis; Cardiac Catheterization; Coronary Artery Bypass; Coronary Disease; Female; Follow-Up Studies; Humans; Infant; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Revascularization; Nitroglycerin; Propranolol; Radiography; Saphenous Vein; Transplantation, Autologous; Warfarin | 1974 |
[On the effect of various cardiac drugs on the connective tissue].
Topics: Animals; Benzoates; Connective Tissue; Coumarins; Dipyridamole; Glycolates; Glycosaminoglycans; Granulation Tissue; Heart; Histological Techniques; Male; Myocardium; Nicotinic Acids; Prenylamine; Propranolol; Rats; Stimulation, Chemical; Sulfur Isotopes; Sympatholytics; Theophylline; Vasodilator Agents; Verapamil | 1967 |
[Internal therapy of peripheral arterial blood circulation disorders].
Topics: Adenosine Triphosphate; Aged; Angiotensin II; Anti-Bacterial Agents; Blood Pressure; Chlorpromazine; Chronic Disease; Collateral Circulation; Coumarins; Epinephrine; Ergot Alkaloids; Exercise Therapy; Femoral Artery; Fibrinolytic Agents; Humans; Infusions, Parenteral; Male; Methoxamine; Nicotinic Acids; Papaverine; Popliteal Artery; Propranolol; Reserpine; Sympatholytics; Sympathomimetics; Thrombosis; Vascular Diseases | 1970 |
Effect of a coronary vasodilating substance, carbocromen, on the coronary blood flow under hypoxia and administration of adrenergic blocking agents.
Topics: Adrenergic beta-Antagonists; Animals; Aorta; Blood Pressure; Cardiac Catheterization; Coronary Circulation; Coronary Vessels; Coumarins; Dogs; Electrodes; Ethylamines; Glycolates; Heart; Heart Rate; Hypoxia; Male; Oxygen; Partial Pressure; Phentolamine; Propranolol; Respiration, Artificial; Vasodilator Agents | 1972 |
Application of blood level data to clinical trials.
Topics: Alkylating Agents; Biopharmaceutics; Disease; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy; Environment; Genetics; Half-Life; Heart; Heart Rate; Hemodynamics; Humans; Isoproterenol; Patients; Pharmaceutical Preparations; Practolol; Propranolol; Protein Binding; Receptors, Drug; Warfarin; Water-Electrolyte Balance | 1974 |
Effect of nitrates and other coronary dilators on large and small coronary vessels: an hypothesis for the mechanism of action of nitrates.
Topics: Aminophylline; Animals; Aorta; Biophysical Phenomena; Biophysics; Blood Circulation; Blood Flow Velocity; Blood Pressure; Coronary Vessels; Coumarins; Dipyridamole; Dogs; Electricity; Glycolates; Hemodynamics; Hyperemia; Isoproterenol; Nitrates; Nitroglycerin; Papaverine; Pentaerythritol Tetranitrate; Prenylamine; Propranolol; Vasodilator Agents; Verapamil | 1969 |
Acute coronary insufficiency. Course and follow-up.
Topics: Adult; Aged; Angina Pectoris; Aspartate Aminotransferases; Coronary Disease; Creatine Kinase; Electrocardiography; Female; Follow-Up Studies; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Myocardial Infarction; Nitrates; Procainamide; Propranolol; Quinidine; Warfarin | 1972 |
[Intensain treatment of acute coronary insufficiency].
Topics: Adult; Coronary Disease; Coumarins; Glycolates; Humans; Male; Middle Aged; Propranolol; Vasodilator Agents; Verapamil | 1970 |
Angina pectoris--II.
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Cholesterol; Cholestyramine Resin; Clofibrate; Diet; Female; Heart Failure; Humans; Hyperlipidemias; Hyperthyroidism; Male; Middle Aged; Myocardium; Oxygen Consumption; Pacemaker, Artificial; Propranolol; Warfarin | 1971 |
Antihypertensive activity of bucumolol, a beta-adrenergic blocking agent, in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Coumarins; Disease Models, Animal; Hypertension; Male; Propanolamines; Propranolol; Rats; Renin-Angiotensin System | 1981 |
Assessment of beta-blockade and the non-specific effect of bucumolol, a beta-adrenergic blocking agent, on atrioventricular conduction in anesthetized dogs.
Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Coumarins; Dogs; Female; Heart Conduction System; Male; Pindolol; Propanolamines; Propranolol; Receptors, Adrenergic; Receptors, Adrenergic, beta; Refractory Period, Electrophysiological | 1981 |
The effect of beta-adrenoceptor antagonists on the pharmacokinetics and pharmacodynamics of warfarin.
Topics: Adrenergic beta-Antagonists; Atenolol; Biological Availability; Drug Interactions; Humans; Kinetics; Male; Metoprolol; Propranolol; Warfarin | 1984 |
The effect of beta-adrenoceptor antagonists on the pharmacokinetics and pharmacodynamics of warfarin after a single dose.
Topics: Adult; Atenolol; Drug Interactions; Factor VII; Heart Rate; Humans; Kinetics; Male; Metoprolol; Propranolol; Prothrombin Time; Receptors, Adrenergic, beta; Warfarin | 1984 |
Interaction between warfarin and propranolol.
Topics: Adult; Animals; Drug Interactions; Half-Life; Humans; Kinetics; Male; Middle Aged; Propranolol; Prothrombin Time; Rabbits; Tissue Distribution; Warfarin | 1984 |
Interaction between warfarin and propranolol.
Topics: Animals; Drug Interactions; Half-Life; Humans; Male; Propranolol; Prothrombin Time; Rabbits; Warfarin | 1984 |
Effect of late pregnancy on salicylate, diazepam, warfarin, and propranolol binding: use of fluorescent probes.
Topics: Adult; Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Fluorescent Dyes; Humans; Orosomucoid; Pregnancy; Propranolol; Protein Binding; Salicylates; Serum Albumin; Warfarin | 1984 |
Comparative effects of two commercially available blood collection tubes on plasma concentrations of drugs.
Topics: Acebutolol; Blood Specimen Collection; Carbamazepine; Diazepam; Digoxin; Ethosuximide; Humans; Nordazepam; Penbutolol; Pharmaceutical Preparations; Propranolol; Quinidine; Salicylates; Time Factors; Valproic Acid; Warfarin | 1980 |
Variations in drug free fraction during alcohol withdrawal.
Topics: Adult; Chemical Fractionation; Diazepam; Ethanol; Fatty Acids; Humans; Male; Middle Aged; Orosomucoid; Propranolol; Protein Binding; Regression Analysis; Serum Albumin; Substance Withdrawal Syndrome; Warfarin | 1983 |
Nonfatty acid-modulated variations in drug binding due to heparin.
Topics: Adult; Diazepam; Fatty Acids, Nonesterified; Female; Heparin; Humans; In Vitro Techniques; Lipoprotein Lipase; Male; Middle Aged; Pharmaceutical Preparations; Propranolol; Protamines; Warfarin | 1982 |
Evidence for binding of certain acidic drugs to alpha 1-acid glycoprotein.
Topics: Humans; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Serum Albumin; Warfarin | 1982 |
Confusion between warfarin and propranolol leading to warfarin overdosage.
Topics: Aged; Hemorrhage; Humans; Hypertension; Male; Medication Errors; Propranolol; Warfarin | 1981 |
Further studies on plasma proteins, lipids, and dye- and drug-binding in a child with analbuminemia.
Topics: Blood Proteins; Bromphenol Blue; Child; Diazepam; Humans; Lipids; Phosphatidylcholine-Sterol O-Acyltransferase; Propranolol; Protein Binding; Radioimmunoassay; Serum Albumin; Warfarin | 1981 |
Drug interactions with cimetidine.
Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin | 1981 |
Protein binding of several drugs in serum and plasma of healthy subjects.
Topics: Adult; Bilirubin; Female; Heparin; Humans; Isoelectric Point; Male; Phenytoin; Plasticizers; Propranolol; Protein Binding; Salicylates; Warfarin | 1980 |
The cardiodynamic and metabolic effects of carbochromen and propranolol on the isolated dog heart.
Topics: Animals; Cardiac Output; Chromonar; Coronary Circulation; Coumarins; Dogs; Female; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Oxygen Consumption; Propranolol | 1980 |
Mechanism of ligand binding to alpha 1-acid glycoprotein (orosomucoid): correlated thermodynamic factors and molecular parameters of polarity.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Hydrogen Bonding; Indoles; Isradipine; Ligands; Nifedipine; Orosomucoid; Progesterone; Propanolamines; Propranolol; Temperature; Thermodynamics; Warfarin | 1995 |
Zileuton for asthma.
Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Intestinal Absorption; Leukotrienes; Lipoxygenase Inhibitors; Propranolol; Theophylline; Warfarin | 1997 |
Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.
Topics: Animals; Blood Proteins; Cell Line; Dogs; Enzyme Activation; Haplorhini; Humans; Imipramine; Metabolic Clearance Rate; Microsomes; Microsomes, Liver; Propranolol; Protein Binding; Rats; Spodoptera; Warfarin | 1997 |
Continuous blood withdrawal as a rapid screening method for determining clearance of oral bioavailability in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Atenolol; Biological Availability; Male; Propranolol; Rats; Rats, Sprague-Dawley; Theophylline; Warfarin | 1998 |
Immobilized artificial membrane (IAM)-HPLC for partition studies of neutral and ionized acids and bases in comparison with the liposomal partition system.
Topics: Alkalies; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anticoagulants; Buffers; Chromatography, High Pressure Liquid; Diazepam; Hydrogen-Ion Concentration; Ions; Kinetics; Lidocaine; Liposomes; Membranes, Artificial; Phosphatidylcholines; Propranolol; Salicylates; Solvents; Temperature; Thermodynamics; Vasodilator Agents; Warfarin | 1999 |
Hyphema associated with pupillary dilation in a patient with exfoliation glaucoma and warfarin therapy.
Topics: Aged; Anticoagulants; Atrial Fibrillation; Carbachol; Cerebrovascular Disorders; Drug Therapy, Combination; Exfoliation Syndrome; Female; Glaucoma; Humans; Hyphema; Latanoprost; Propranolol; Prostaglandins F, Synthetic; Pupil; Warfarin | 1999 |
Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase.
Topics: Anticoagulants; Antineoplastic Agents, Hormonal; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Carcinogens; Cell Division; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diuretics, Osmotic; GABA Modulators; Gene Expression Regulation, Enzymologic; Genetic Vectors; Humans; Indoles; Mammary Tumor Virus, Mouse; Mannitol; Microscopy, Electron; Microsomes; Midazolam; Mixed Function Oxygenases; Nifedipine; Oxidoreductases; Propranolol; Pyridines; Sympatholytics; Testosterone; Tetradecanoylphorbol Acetate; Transfection; Tritium; Warfarin | 1999 |
Chromatographic evaluation of structure selective and enantioselective retention of amines and acids on cellobiohydrolase I wild type and its mutant D214N.
Topics: Acids; Amino Alcohols; Binding Sites; Bromides; Cellobiose; Cellulase; Cellulose 1,4-beta-Cellobiosidase; Chromatography; Enzymes, Immobilized; Hexanes; Hydrogen-Ion Concentration; Molecular Structure; Mutagenesis, Site-Directed; Osmolar Concentration; Propranolol; Stereoisomerism; Structure-Activity Relationship; Sulfonic Acids; Thermodynamics; Warfarin | 1999 |
Separation of enantiomers on HPLC chiral stationary phases based on human plasma alpha1-acid glycoprotein: effect of sugar moiety on chiral recognition ability.
Topics: Alprenolol; Benzoin; Bupivacaine; Carbohydrates; Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Glycoside Hydrolases; Glycosylation; Humans; Hydantoins; Hydrogen-Ion Concentration; Molecular Weight; Orosomucoid; Oxprenolol; Phenylbutyrates; Propionates; Propranolol; Protein Binding; Silicon Dioxide; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Structure-Activity Relationship; Warfarin | 2000 |
Characterization of a binding site of UCN-01, a novel anticancer drug on alpha-acid glycoprotein.
Topics: Alkaloids; Antineoplastic Agents; Binding, Competitive; Orosomucoid; Progesterone; Propranolol; Staurosporine; Ultracentrifugation; Warfarin | 2000 |
Enantioselective supercritical fluid chromatography using ristocetin A chiral stationary phases.
Topics: 2,4-Dichlorophenoxyacetic Acid; Anesthetics, Local; Anti-Bacterial Agents; Bupivacaine; Chromatography, Liquid; Coumarins; Evaluation Studies as Topic; Ketoprofen; Metoprolol; Propranolol; Reagent Kits, Diagnostic; Ristocetin; Stereoisomerism; Thalidomide; Warfarin | 2000 |
Alpha-tocopherol influences the lipid membrane affinity of desipramine in a pH-dependent manner.
Topics: alpha-Tocopherol; Antidepressive Agents, Tricyclic; Antioxidants; Cholesterol; Chromans; Desipramine; Hydrogen-Ion Concentration; Liposomes; Membrane Lipids; Phosphatidylcholines; Phosphatidylinositols; Potentiometry; Propranolol; Tocopherols; Warfarin | 2004 |
Bronchodilator activity of Phymatodes scolopendria (Burm.) Ching and its bioactive constituent.
Topics: Animals; Bronchodilator Agents; Calcium Chloride; Coumarins; Female; Guinea Pigs; Histamine Antagonists; Male; Plant Extracts; Polypodiaceae; Potassium Chloride; Propranolol; Theophylline; Trachea | 2005 |
Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.
Topics: Animals; Biological Transport; Coumarins; Cryopreservation; Diffusion; Drug Evaluation, Preclinical; Hepatocytes; Humans; In Vitro Techniques; Kinetics; Metabolic Clearance Rate; Microsomes, Liver; Midazolam; Phenacetin; Propranolol; Rats; Reproducibility of Results | 2006 |
Fluorescence determination of enantiomeric composition of pharmaceuticals via use of ionic liquid that serves as both solvent and chiral selector.
Topics: Ions; Naproxen; Pharmaceutical Preparations; Propranolol; Quaternary Ammonium Compounds; Solvents; Spectrometry, Fluorescence; Stereoisomerism; Warfarin | 2006 |
Molecular interactions in lipophilic environments studied by electrochemistry at interfaces between immiscible electrolyte solutions.
Topics: Buffers; Cholesterol; Diflunisal; Electrochemistry; Electrolytes; Hydrophobic and Hydrophilic Interactions; Lidocaine; Ligands; Prilocaine; Propranolol; Solutions; Warfarin | 2008 |
Impact of plasticity and flexibility on docking results for cytochrome P450 2D6: a combined approach of molecular dynamics and ligand docking.
Topics: 3,4-Methylenedioxyamphetamine; Catalytic Domain; Chlorpromazine; Computer Simulation; Coumarins; Cytochrome P-450 CYP2D6; Ligands; Models, Chemical; Molecular Structure; Propranolol; Stereoisomerism; Tamoxifen | 2008 |
Approach for reliable evaluation of drug proteins interactions using surface plasmon resonance technology.
Topics: Dimethyl Sulfoxide; Humans; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Proteins; Reproducibility of Results; Stereoisomerism; Substrate Specificity; Surface Plasmon Resonance; Warfarin | 2009 |
Evaluation of ligand-selector interaction from effective diffusion coefficient.
Topics: Adrenergic beta-Antagonists; Animals; Anticoagulants; Antitussive Agents; Cattle; Chromatography, High Pressure Liquid; Cyclodextrins; Diffusion; Ligands; Nitrophenols; Noscapine; Pharmaceutical Preparations; Photosensitizing Agents; Propranolol; Riboflavin; Salicylic Acid; Serum Albumin, Bovine; Warfarin | 2010 |
Production of dosage forms for oral drug delivery by laminar extrusion of wet masses.
Topics: Administration, Oral; Cellulose; Chemistry, Pharmaceutical; Coumarins; Drug Delivery Systems; Elasticity; Hypromellose Derivatives; Lactose; Methylcellulose; Propranolol; Solubility; Stress, Mechanical; Technology, Pharmaceutical; Tensile Strength; Time Factors; Water | 2013 |
Multilayer laminar co-extrudate as a novel controlled release dosage form.
Topics: Administration, Oral; Calcium Phosphates; Cellulose; Coumarins; Delayed-Action Preparations; Dosage Forms; Excipients; Hypromellose Derivatives; Lactose; Methylcellulose; Propranolol; Technology, Pharmaceutical; Water | 2013 |
How I treat splanchnic vein thrombosis.
Topics: Aged; Anticoagulants; Female; Heparin, Low-Molecular-Weight; Humans; Male; Mesenteric Veins; Middle Aged; Portal Vein; Practice Guidelines as Topic; Propranolol; Risk Factors; Splanchnic Circulation; Splenic Vein; Treatment Outcome; Vasodilator Agents; Venous Thrombosis; Warfarin | 2014 |
Influence of ligand binding on structure and thermostability of human α1-acid glycoprotein.
Topics: Binding Sites; Humans; Models, Molecular; Molecular Docking Simulation; Orosomucoid; Progesterone; Propranolol; Protein Binding; Protein Stability; Protein Structure, Secondary; Spectrum Analysis, Raman; Thermodynamics; Tryptophan; Warfarin | 2016 |
On-column entrapment of alpha1-acid glycoprotein for studies of drug-protein binding by high-performance affinity chromatography.
Topics: Antihypertensive Agents; Chromatography, Affinity; Chromatography, High Pressure Liquid; Equipment Design; Humans; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Warfarin | 2016 |
Studies of drug interactions with alpha
Topics: Antibodies; Chlorpromazine; Chromatography, Affinity; Disopyramide; Drug Interactions; Humans; Imipramine; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Warfarin | 2017 |
Cerebral venous sinus thrombosis precipitated by Graves' disease.
Topics: Adrenergic beta-Antagonists; Adult; Anticoagulants; Antithyroid Agents; Carbimazole; Computed Tomography Angiography; Enoxaparin; Graves Disease; Humans; Magnetic Resonance Imaging; Male; Phlebography; Propranolol; Sinus Thrombosis, Intracranial; Warfarin | 2018 |
Incidence and risk factors of warfarin therapy complications in community hospitals, central and eastern regions, Thailand: a retrospective, multicenter, cohort study.
Topics: Anticoagulants; Cohort Studies; Hospitals, Community; Humans; Incidence; Propranolol; Retrospective Studies; Risk Factors; Thailand; Warfarin | 2023 |