Page last updated: 2024-08-16

propranolol and debrisoquin

propranolol has been researched along with debrisoquin in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (75.00)	18.7374
1990's	4 (11.11)	18.2507
2000's	3 (8.33)	29.6817
2010's	2 (5.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Benton, F; Turner, R; White, P	1
Talbot, S	1
Brunner, HR; Ferguson, RK; Gavras, H; Turini, GA; Waeber, B	1
Myers, MG	1
Aminu, J; Vere, DW	1
Akinkugbe, OO; Carlisle, R; Olatunde, A	1
Pincus, R	1
Giwa, SO; Olatunde, IA	1
Fujita, S; Hirobe, M; Masubuchi, Y; Narimatsu, S; Ohta, S; Suzuki, T; Tachibana, M	1
Araki, J; Masubuchi, Y; Narimatsu, S; Suzuki, T	1
Anthony, LB; Roden, DM; Wood, AJ; Zhou, HH	1
Biollaz, J; Koshakji, RP; Shaheen, O; Wilkinson, GR; Wood, AJ	1
Anthony, L; Koshakji, R; Wood, AJ	1
Smith, RL	1
Lennard, MS; Silas, JH; Tucker, GT; Woods, HF	1
Bax, ND; Lennard, MS; Shaw, L; Tucker, GT; Woods, HF	1
Hayashi, M; Takase, M	2
Laverty, R	1
O'Brien, BW	1
Aminu, J	1
Fleminger, R; Paykel, ES; Watson, JP	1
Freestone, S; Jackson, PR; Lennard, MS; Ramsay, LE; Tucker, GT; Woods, HF	2
Avigdor, L; Brunner, HR; Waeber, B	2
Koshakji, RP; Raghuram, TC; Wilkinson, GR; Wood, AJ	1
Chadwick, IG; Ellis, SW; Haq, I; Jackson, PR; Lennard, MS; Ramsay, LE; Rowland, K; Tucker, GT; Yeo, WW	1
Blackburn, MG; Ellis, SW; Harlow, J; Hayhurst, GP; Larsson, C; Lennard, MS; Lightfoot, T; Lim, CK; Mahling, J; Rowland-Yeo, K; Smith, G; Tucker, GT; Wolf, CR	1
Chow, T; Funae, Y; Hiroi, T; Imaoka, S	1

Reviews

3 review(s) available for propranolol and debrisoquin

Article	Year
New drugs in hypertension. Canadian Medical Association journal, 1977, Jan-22, Volume: 116, Issue:2 Topics: Antihypertensive Agents; Bethanidine; Clonidine; Debrisoquin; Female; Humans; Hypertension; Male; Propranolol	1977
The mechanisms of action of some antihypertensive drugs. British medical bulletin, 1973, Volume: 29, Issue:2 Topics: Animals; Antihypertensive Agents; Brain; Bretylium Compounds; Clonidine; Debrisoquin; Diuretics; Guanethidine; Heart Rate; Humans; Hydralazine; Hypertension; Methyldopa; Neurons; Normetanephrine; Propranolol; Receptors, Adrenergic; Synaptic Transmission	1973
Psychiatric side effects of antihypertensive drugs other than reserpine. Journal of clinical psychopharmacology, 1982, Volume: 2, Issue:1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin; Depression; Dreams; Drug Interactions; Female; Ganglionic Blockers; Guanethidine; Hallucinations; Humans; Hydralazine; Hypotension; Male; Mental Disorders; Mental Processes; Methyldopa; Propranolol; Psychotropic Drugs; Sleep; Veratrum Alkaloids	1982

Trials

4 trial(s) available for propranolol and debrisoquin

Article	Year
The position of beta-blockers in antihypertensive therapy. Comparison with other antihypertensive agents. Cardiology, 1979, Volume: 64 Suppl 1 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Debrisoquin; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Isoquinolines; Male; Methyldopa; Middle Aged; Placebos; Propranolol; Pulse	1979
A longitudinal study of the mechanisms of action of debrisoquine and propranolol. British journal of clinical pharmacology, 1978, Volume: 6, Issue:1 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Debrisoquin; Double-Blind Method; Female; Humans; Hypertension; Isoquinolines; Longitudinal Studies; Male; Middle Aged; Pressoreceptors; Propranolol; Regional Blood Flow; Time Factors	1978
[Evaluation by practicing physicians of the antihypertensive efficacy of debrisoquin, methyldopa and propranolol]. Schweizerische medizinische Wochenschrift, 1983, Mar-05, Volume: 113, Issue:9 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Debrisoquin; Female; Heart Rate; Humans; Hypertension; Isoquinolines; Male; Methyldopa; Middle Aged; Placebos; Posture; Propranolol	1983
Inhibition of CYP2D6 activity by treatment with propranolol and the role of 4-hydroxy propranolol. British journal of clinical pharmacology, 1994, Volume: 38, Issue:1 Topics: Adult; Aged; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Male; Metoprolol; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Phenotype; Propranolol; Recombinant Proteins; Saccharomyces cerevisiae	1994

Other Studies

29 other study(ies) available for propranolol and debrisoquin

Article	Year
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
The management of hypertension with special reference to debrisoquine and beta blockade. The Practitioner, 1976, Volume: 216, Issue:1294 Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Debrisoquin; Diuretics; Female; Humans; Hypertension; Isoquinolines; Male; Middle Aged; Oxprenolol; Propranolol	1976
Angina in hypertensive patients. With particular reference to the negative chronotropic effects of sympatholytic therapy. Cardiology, 1976, Volume: 61, Issue:4 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Bethanidine; Blood Pressure; Debrisoquin; Drug Therapy, Combination; Guanethidine; Heart Rate; Humans; Hypertension; Male; Methyldopa; Oxprenolol; Physical Exertion; Propranolol; Sympatholytics	1976
Editorial: Adrenergic-neuron and beta-receptor blockade in hypertension. Lancet (London, England), 1976, May-15, Volume: 1, Issue:7968 Topics: Antihypertensive Agents; Debrisoquin; Drug Evaluation; Drug Therapy, Combination; Humans; Hypertension; Isoquinolines; Oxprenolol; Propranolol	1976
Beta-adrenergic blockers in the treatment of hypertension--experience with propranolol at Ibadan, Nigeria. East African medical journal, 1977, Volume: 54, Issue:4 Topics: Adult; Aged; Debrisoquin; Drug Therapy, Combination; Female; Humans; Hydroflumethiazide; Hypertension; Male; Methyldopa; Middle Aged; Nigeria; Propranolol	1977
Letter: Are beta blockers better? The Medical journal of Australia, 1975, Sep-20, Volume: 2, Issue:12 Topics: Debrisoquin; Female; Humans; Hypertension; Methyldopa; Propranolol	1975
Proceedings: Effects of debrisoquine and propranolol on nerve-mediated and noradrenaline-induced contractions of the isolated rat hypogastric nerve-vas deferens preparation. West African journal of pharmacology and drug research, 1975, Volume: 2, Issue:1 Topics: Animals; Debrisoquin; Drug Synergism; Hypogastric Plexus; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Norepinephrine; Propranolol; Rats; Vas Deferens	1975
Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1992, Jan-06, Volume: 6, Issue:2 Topics: Amino Acid Sequence; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Isoenzymes; Isoquinolines; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Naphthols; Phenobarbital; Propranolol; Rabbits; Rats; Rats, Inbred Strains; Sex Characteristics; Species Specificity; Tetrahydroisoquinolines	1992
Metabolic activation of lidocaine and covalent binding to rat liver microsomal protein. Biochemical pharmacology, 1992, Jun-23, Volume: 43, Issue:12 Topics: Animals; Biotransformation; Carbon Monoxide; Cysteine; Cytochrome P-450 Enzyme System; Debrisoquin; Dose-Response Relationship, Drug; Female; Glutathione; Lidocaine; Male; Microsomes, Liver; NADP; Oxygen; Proadifen; Propranolol; Proteins; Quinidine; Rats; Rats, Inbred Strains	1992
Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:6 Topics: Adult; Analysis of Variance; Debrisoquin; Drug Interactions; Electrocardiography; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Propranolol; Quinidine; Stereoisomerism	1990
Influence of debrisoquin phenotype on the inducibility of propranolol metabolism. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:4 Topics: Adult; Debrisoquin; Enzyme Induction; Glucuronates; Humans; Isoquinolines; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Phenotype; Propranolol	1989
Racial differences in drug response. The New England journal of medicine, 1989, Jul-27, Volume: 321, Issue:4 Topics: Asian People; China; Debrisoquin; Humans; Male; Propranolol	1989
Multiple pathways of propranolol's metabolism are inhibited by debrisoquin. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:3 Topics: Absorption; Administration, Oral; Adult; Debrisoquin; Dose-Response Relationship, Drug; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Propranolol	1989
Polymorphic metabolism of the beta-adrenoreceptor blocking drugs and its clinical relevance. European journal of clinical pharmacology, 1985, Volume: 28 Suppl Topics: Adrenergic beta-Antagonists; Animals; Biological Availability; Blood Pressure; Debrisoquin; Ethanolamines; Glucuronates; Humans; Hydroxylation; Kinetics; Lipids; Metoprolol; Phenotype; Polymorphism, Genetic; Propranolol; Solubility; Structure-Activity Relationship; Timolol	1985
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Debrisoquin; Genetic Variation; Humans; Hypertension; Isoquinolines; Kinetics; Male; Metoprolol; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Propranolol; Structure-Activity Relationship; Timolol	1986
Irreversible binding and metabolism of propranolol by human liver microsomes--relationship to polymorphic oxidation. Biochemical pharmacology, 1987, Jul-15, Volume: 36, Issue:14 Topics: Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Debrisoquin; Humans; Hydroxylation; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Polymorphism, Genetic; Propranolol; Protein Binding	1987
[A population study of the poor metabolizers of the debrisoquine type in Japan]. Nippon Ganka Gakkai zasshi, 1985, Volume: 89, Issue:8 Topics: Administration, Oral; Asian People; Debrisoquin; Humans; Isoquinolines; Japan; Male; Propranolol; Timolol	1985
Population study of poor debrisoquine-type metabolizers of propranolol among Japanese. Japanese journal of ophthalmology, 1985, Volume: 29, Issue:3 Topics: Adult; Blood Pressure; Debrisoquin; Humans; Intraocular Pressure; Isoquinolines; Japan; Male; Population Surveillance; Propranolol; Pulse; Time Factors	1985
The management of essential hypertension. JAMA, 1974, Aug-05, Volume: 229, Issue:6 Topics: Antihypertensive Agents; Benzyl Compounds; Debrisoquin; Diazoxide; Diuretics; Guanidines; Humans; Hypertension; Methyldopa; Pentolinium Tartrate; Posture; Propranolol; Sodium Chloride Symporter Inhibitors; Sulfates; United Kingdom	1974
Proceedings: Parasympathetic blockade in patients treated with debrisoquine and with propranolol. West African journal of pharmacology and drug research, 1974, Volume: 2, Issue:1 Topics: Debrisoquin; Depression, Chemical; Heart Rate; Humans; Isoquinolines; Parasympathetic Nervous System; Propranolol	1974
Beta-blockers and drug oxidation status. Lancet (London, England), 1982, Feb-27, Volume: 1, Issue:8270 Topics: Aged; Coronary Disease; Debrisoquin; Female; Humans; Oxidation-Reduction; Phenotype; Propranolol; Syncope	1982
The oral clearance and beta-adrenoceptor antagonist activity of propranolol after single dose are not related to debrisoquine oxidation phenotype. British journal of clinical pharmacology, 1984, Volume: 17 Suppl 1 Topics: Adrenergic beta-Antagonists; Debrisoquin; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Oxidation-Reduction; Phenotype; Propranolol	1984
Long-term follow-up study of hypertensive patients by practicing internists after a controlled drug trial. Clinical therapeutics, 1984, Volume: 6, Issue:4 Topics: Antihypertensive Agents; Blood Pressure; Debrisoquin; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Long-Term Care; Male; Mefruside; Methyldopa; Middle Aged; Propranolol	1984
Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:1 Topics: Adult; Chromatography, High Pressure Liquid; Debrisoquin; Heart Rate; Humans; Hydroxylation; Male; Phenotype; Physical Exertion; Polymorphism, Genetic; Propranolol	1984
The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol. British journal of clinical pharmacology, 1984, Volume: 17, Issue:6 Topics: Adult; Debrisoquin; Humans; Isoquinolines; Kinetics; Male; Oxidation-Reduction; Phenotype; Propranolol	1984
Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6. The Biochemical journal, 2000, Feb-01, Volume: 345 Pt 3 Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalytic Domain; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Enzyme Inhibitors; Kinetics; Ligands; Metoprolol; Mutagenesis, Site-Directed; Oxidation-Reduction; Propranolol; Quinidine; Quinine; Serine; Substrate Specificity; Yeasts	2000
Catalytic specificity of CYP2D isoforms in rat and human. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:9 Topics: Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Debrisoquin; Ethanolamines; Humans; In Vitro Techniques; Isoenzymes; Magnetic Resonance Spectroscopy; Microsomes, Liver; Mixed Function Oxygenases; Propranolol; Rats; Recombinant Proteins; Substrate Specificity	2002