Page last updated: 2024-08-16

propranolol and clozapine

propranolol has been researched along with clozapine in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (11.67)	18.7374
1990's	4 (6.67)	18.2507
2000's	20 (33.33)	29.6817
2010's	27 (45.00)	24.3611
2020's	2 (3.33)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Dalvie, D; Loi, CM; Smith, DA	1
Bojarski, AJ; Gunia, A; Marona, H; Pytka, K; Satała, G; Siwek, A; Szkaradek, N; Szneler, E; Waszkielewicz, AM	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Handzlik, J; Jankowska, A; Jastrzębska-Więsek, M; Kieć-Kononowicz, K; Kucwaj-Brysz, K; Kurczab, R; Nitek, W; Partyka, A; Satała, G; Siwek, A; Wesołowska, A; Żesławska, E	1
Chen, Y; Deng, X; He, H; Hu, Z; Huang, H; Jiang, H; Li, L; Xu, Q; Zhou, R	1
Campbell, WB; Harper, DC; Keeton, TK; Pettinger, WA	1
Hicks, TP; McLennan, H	1
Lee, KY; Nurok, D; Zlatkis, A	1
Proppe, DG; Vetter, PH	1
Christison, GW; Kirch, DG; Wyatt, RJ	1
Chang, KJ; Ferris, RM; Russell, A; Tang, FL	1
Borsini, F; Nowakowska, E; Samanin, R	1
Nobrega, JN; Wiener, NI	1
Vanelle, JM	1
Goldman, M; Kalian, M; Lerner, V	1
Koller, W; Marjama-Lyons, J	1
Fujiwara, Y; Hamamura, T; Kuroda, S; Lee, Y; Ohashi, K; Suzuki, H	1
Ball, P; Baymiller, SP; Buchanan, RW; McMahon, RP	1
Dawe, GS; Lim, EP; Nagarajah, R; Verma, V	1
Ameen, S; Sahoo, S	1
Abelmann, WH; Amende, I; Green, AI; Hampton, TG; Malek, S; Min, JY; Morgan, JP; Wang, JF; Yan, X; Zeind, J	1
Ekström, J; Godoy, T; Riva, A	1
Bosch, TM; Hovens, JE; Mookhoek, EJ; van Dam, D	1
Abbruzzese, G; Albanese, A; Allegra, R; Aniello, MS; Berardelli, A; Bruno, E; Colosimo, C; Elia, AE; Filippini, G; Martinelli, P; Martino, D; Murgia, D; Nicoletti, A; Picillo, M; Quattrocchi, G; Squintani, G; Zappia, M	1
Bosco, DB; Chen, T; Dong, H; Eyo, UB; Li, Y; Liu, YU; Umpierre, AD; Wu, LJ; Ying, Y; Zheng, J; Zhu, J	1
Abdel-Wahab, BA; Hetta, HF; Mohammed, HM; Mohammed, NA; Salem, SY	1

Reviews

6 review(s) available for propranolol and clozapine

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
When symptoms persist: choosing among alternative somatic treatments for schizophrenia. Schizophrenia bulletin, 1991, Volume: 17, Issue:2 Topics: Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Clozapine; Double-Blind Method; Electroconvulsive Therapy; Humans; Levodopa; Lithium; Propranolol; Reserpine; Schizophrenia	1991
[Resistant schizophrenia: what chemotherapy?]. Annales medico-psychologiques, 1993, Volume: 151, Issue:4 Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Clozapine; Drug Therapy, Combination; Humans; Lithium; Propranolol; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1993
Tremor-predominant Parkinson's disease. Approaches to treatment. Drugs & aging, 2000, Volume: 16, Issue:4 Topics: Acetates; Amantadine; Amines; Antiparkinson Agents; Botulinum Toxins; Cholinergic Antagonists; Clonazepam; Clozapine; Cyclohexanecarboxylic Acids; Dopamine Agonists; Electric Stimulation Therapy; Gabapentin; Gamma Rays; gamma-Aminobutyric Acid; Globus Pallidus; Humans; Neurosurgical Procedures; Parkinson Disease; Propranolol; Radiosurgery; Thalamus; Tremor	2000
Treatment of essential tremor: a systematic review of evidence and recommendations from the Italian Movement Disorders Association. Journal of neurology, 2013, Volume: 260, Issue:3 Topics: Animals; Clinical Trials as Topic; Clozapine; Deep Brain Stimulation; Essential Tremor; Humans; Italy; Movement Disorders; Practice Guidelines as Topic; Propranolol; Treatment Outcome	2013

Trials

2 trial(s) available for propranolol and clozapine

Article	Year
When symptoms persist: choosing among alternative somatic treatments for schizophrenia. Schizophrenia bulletin, 1991, Volume: 17, Issue:2 Topics: Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Clozapine; Double-Blind Method; Electroconvulsive Therapy; Humans; Levodopa; Lithium; Propranolol; Reserpine; Schizophrenia	1991
Serum glucose and lipid changes during the course of clozapine treatment: the effect of concurrent beta-adrenergic antagonist treatment. Schizophrenia research, 2003, Jan-01, Volume: 59, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Analysis of Variance; Antipsychotic Agents; Atenolol; Blood Glucose; Clozapine; Double-Blind Method; Drug Therapy, Combination; Female; Haloperidol; Humans; Lipids; Male; Propranolol; Psychotic Disorders; Schizophrenia; Statistics, Nonparametric; Weight Gain	2003

Article

Year

When symptoms persist: choosing among alternative somatic treatments for schizophrenia.

Schizophrenia bulletin, 1991, Volume: 17, Issue:2

Topics: Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Clozapine; Double-Blind Method; Electroconvulsive Therapy; Humans; Levodopa; Lithium; Propranolol; Reserpine; Schizophrenia

1991

Serum glucose and lipid changes during the course of clozapine treatment: the effect of concurrent beta-adrenergic antagonist treatment.

Schizophrenia research, 2003, Jan-01, Volume: 59, Issue:1

Topics: Adrenergic beta-Antagonists; Adult; Analysis of Variance; Antipsychotic Agents; Atenolol; Blood Glucose; Clozapine; Double-Blind Method; Drug Therapy, Combination; Female; Haloperidol; Humans; Lipids; Male; Propranolol; Psychotic Disorders; Schizophrenia; Statistics, Nonparametric; Weight Gain

2003

Other Studies

53 other study(ies) available for propranolol and clozapine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery. Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19 Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Administration, Oral; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Half-Life; Kinetics; Piperazine; Piperazines; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin; Seizures; Xanthones	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT European journal of medicinal chemistry, 2018, Mar-10, Volume: 147 Topics: Animals; Antidepressive Agents; Behavior, Animal; Computer-Aided Design; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Hydantoins; Male; Mice; Models, Molecular; Molecular Structure; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship	2018
Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors. Bioorganic & medicinal chemistry letters, 2020, 04-01, Volume: 30, Issue:7 Topics: Animals; Drug Discovery; HT29 Cells; Humans; Inflammasomes; Molecular Structure; NLR Family, Pyrin Domain-Containing 3 Protein; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazolidines	2020
Evidence for a renal alpha-adrenergic receptor inhibiting renin release. Circulation research, 1976, Volume: 38, Issue:5 Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Chlorisondamine; Clonidine; Clozapine; Hyponatremia; Juxtaglomerular Apparatus; Male; Methoxamine; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Receptors, Adrenergic; Renin; Sympathetic Nervous System	1976
Actions of octopamine upon dorsal horn neurones of the spinal cord. Brain research, 1978, Nov-24, Volume: 157, Issue:2 Topics: Animals; Clozapine; Dopamine; Electrophysiology; Glutamates; Interneurons; Metoclopramide; Norepinephrine; Octopamine; Propranolol; Rats; Receptors, Adrenergic; Spinal Cord	1978
Simultaneous determination of antiarrhythmia drugs by high-performance thin-layer chromatography. Journal of chromatography, 1978, Oct-01, Volume: 158 Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Clozapine; Humans; Lidocaine; Phenytoin; Procainamide; Propranolol; Quinidine	1978
Clozapine-induced coma. The Journal of nervous and mental disease, 1992, Volume: 180, Issue:1 Topics: Clozapine; Coma; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Middle Aged; Propranolol; Psychotic Disorders; Tachycardia	1992
Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life sciences, 1986, Jun-23, Volume: 38, Issue:25 Topics: Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain; Carbazoles; Clozapine; Guinea Pigs; Kinetics; Male; Methylphenidate; Mice; Phenazocine; Phencyclidine; Phenoxybenzamine; Propranolol; Receptors, Opioid; Receptors, sigma; Sulpiride	1986
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs. Life sciences, 1984, Mar-19, Volume: 34, Issue:12 Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidine; Clozapine; Depressive Disorder; Desipramine; Dibenzazepines; Haloperidol; Humans; Male; Metoclopramide; Phentolamine; Prazosin; Propranolol; Rats; Sulpiride	1984
Effects of catecholamine agonist and antagonist drugs on acute stomach ulceration induced by medial hypothalamic lesions in rats. Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:5 Topics: Amphetamine; Animals; Catecholamines; Chlorpromazine; Clozapine; Desipramine; Haloperidol; Hypothalamus, Middle; Isoproterenol; Male; Pargyline; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Stomach Ulcer	1983
Atypical variants of tardive dyskinesia, treated by a combination of clozapine with propranolol and clozapine with tetrabenazine. The Journal of nervous and mental disease, 1993, Volume: 181, Issue:10 Topics: Adult; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Humans; Male; Propranolol; Schizophrenia; Tetrabenazine	1993
Clozapine- and olanzapine-induced Fos expression in the rat medial prefrontal cortex is mediated by beta-adrenoceptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 23, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Antipsychotic Agents; Benzodiazepines; Cell Count; Cell Nucleus; Clozapine; Locus Coeruleus; Male; Neurons; Olanzapine; Pirenzepine; Prefrontal Cortex; Propranolol; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Adrenergic, beta	2000
Propranolol blocks chronic risperidone treatment-induced enhancement of spatial working memory performance of rats in a delayed matching-to-place water maze task. Psychopharmacology, 2007, Volume: 191, Issue:2 Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Male; Maze Learning; Memory; Propranolol; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Space Perception	2007
Acute nocturnal akathisia induced by clozapine. Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2 Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Circadian Rhythm; Clozapine; Humans; Male; Propranolol; Schizophrenia	2007
Clozapine-induced myocarditis: role of catecholamines in a murine model. European journal of pharmacology, 2008, Sep-11, Volume: 592, Issue:1-3 Topics: Adrenergic beta-Antagonists; Animals; Antipsychotic Agents; Catecholamines; Clozapine; Cytokines; Enzyme-Linked Immunosorbent Assay; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Propranolol; Tumor Necrosis Factor-alpha	2008
Clozapine-induced salivation: interaction with N-desmethylclozapine and amisulpride in an experimental rat model. European journal of oral sciences, 2011, Volume: 119, Issue:4 Topics: Abdomen; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amisulpride; Animals; Antipsychotic Agents; Blood Pressure; Chorda Tympani Nerve; Clozapine; Female; Lingual Nerve; Liver Circulation; Methacholine Chloride; Models, Animal; Muscarinic Agonists; Parasympathectomy; Phentolamine; Propranolol; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Saliva; Salivation; Submandibular Gland; Sulpiride; Time Factors	2011
[Treatment of clozapine-induced tachycardia with propranolol complicated by psoriasis]. Tijdschrift voor psychiatrie, 2012, Volume: 54, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Antipsychotic Agents; Clozapine; Humans; Male; Propranolol; Psoriasis; Psychotic Disorders; Schizophrenia; Tachycardia	2012
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Nature neuroscience, 2019, Volume: 22, Issue:11 Topics: Animals; Brain; Clozapine; CX3C Chemokine Receptor 1; Isoflurane; Mice; Mice, Knockout; Mice, Transgenic; Microglia; Microinjections; Muscimol; Neurons; Norepinephrine; Optogenetics; Propanolamines; Propranolol; Receptors, Purinergic P2Y12; Sensory Deprivation; Somatosensory Cortex; Tetrodotoxin; Wakefulness	2019
The role of vimentin, Connexin-43 proteins, and oxidative stress in the protective effect of propranolol against clozapine-induced myocarditis and apoptosis in rats. European journal of pharmacology, 2021, Jan-05, Volume: 890 Topics: Adrenergic beta-Antagonists; Animals; Antipsychotic Agents; Apoptosis; Cardiotonic Agents; Caspase 3; Clozapine; Connexin 43; Creatine Kinase; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Male; Myocarditis; Myocardium; Oxidative Stress; Propranolol; Rats, Wistar; Troponin I; Vimentin	2021