propranolol has been researched along with caffeine in 200 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 96 (48.00) | 18.7374 |
| 1990's | 17 (8.50) | 18.2507 |
| 2000's | 45 (22.50) | 29.6817 |
| 2010's | 37 (18.50) | 24.3611 |
| 2020's | 5 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Blake, JF; Curatolo, WJ; Lombardo, F | 1 |
| Coassolo, P; Lavé, T; Schneider, G | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Jolivette, LJ; Ward, KW | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Giralt, E; Malakoutikhah, M; Teixidó, M | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Giralt, E; Malakoutikhah, M; Prades, R; Teixidó, M | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Akamatsu, M | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Botta, L; Brai, A; Calandro, P; Canducci, F; Carda, M; Chiariello, M; Falomir, E; Maccari, G; Martí-Centelles, R; Tiberi, M; Zamperini, C | 1 |
| Luzzio, FA; Monsen, PJ | 1 |
| Bartel, K; Bracher, F; Christianson, DW; Herp, D; Jung, M; Marek, M; Müller, M; Ong, N; Porter, NJ; Robaa, D; Romier, C; Schmidtkunz, K; Senger, J; Shaik, TB; Sippl, W; Vögerl, K | 1 |
| Helle, KB; Storesund, A | 1 |
| Boissier, JR; Dumont, C; Oberlander, C; Peterfalvi, M | 1 |
| Borasio, PG; Vassalle, M | 1 |
| Hill, RM; Stern, L | 1 |
| Elgjo, K | 1 |
| Duncan, PE; Griffin, JP; Solomon, SS | 1 |
| Hittelman, KJ; Rosak, C | 1 |
| Il'ina, NA; Khokhlov, AP; Poliakova, NF | 1 |
| Aparicio, NJ; De Turner, E; Schwarzstein, L; Turner, D | 1 |
| Belogubova, EG; Pastukhov, IuF; Valov, RP | 1 |
| Dickbuch, S; Gorin, E | 1 |
| Michibayashi, T; Miyahara, M | 1 |
| Reus, VI | 1 |
| Chiba, S; Furukawa, Y; Kobayashi, M | 1 |
| Ohkawa, H | 1 |
| Hoffmann, A; Siegers, CP; Sierra-Callejas, JL; Strubelt, O | 1 |
| Fujii, T | 1 |
| Haist, RE; Lin, BJ | 1 |
| Matkó, I; Petri, G; Szenohradszky, J; Tárnoky, K | 1 |
| Bishopric, NH; Sato, B; Webster, KA | 1 |
| Røed, A | 1 |
| Kihara, Y; Morgan, JP | 1 |
| Gaasch, WH; Zile, MR | 1 |
| Fredricsson, B; Pousette, A; Rogberg, L | 1 |
| Mersmann, HJ | 1 |
| Baldwin, HA; File, SE | 1 |
| Satoh, H; Vassalle, M | 1 |
| Ording, H | 1 |
| Breier, A; Charney, DS; Heninger, GR | 1 |
| Obara, K; Yamada, T | 1 |
| Bukowiecki, LJ | 1 |
| Turner, P | 1 |
| Bielecki, M; Moulin, M; Pons, L; Potier, JC; Trenque, T | 1 |
| Goldstein, DA; Hughes, HE | 1 |
| Horváth, T; Jávor, T; Rechenbach, C; Traeger, A | 1 |
| Butman, SM; Colombo, A; Olson, HG; Piters, KM | 1 |
| Malencik, DA; Su, JY | 1 |
| Simon, OR; Singh, PD | 1 |
| Austen, KF; Stechschulte, DJ | 1 |
| Estler, CJ | 1 |
| Ishii, N; Mori, M; Takamori, M | 1 |
| Assem, ES; Schild, HO; Wan, BY | 1 |
| Bentley, PJ; Chiarandini, DJ | 1 |
| Nayler, WG | 1 |
| Strubelt, O | 2 |
| Siegers, CP; Strubelt, O | 3 |
| Inesi, G; Pohl, WG; Pretorius, PJ; Smithen, CS | 1 |
| Becker, JA; Marquis, NR; Vigdahl, RL | 1 |
| Varagić, VM; Zugić, M | 1 |
| Gibson, W; Jessup, S; Ramwell, P; Shaw, J | 1 |
| Langendorff, HM | 1 |
| Jampol, LM; Neufeld, AH; Sears, ML | 1 |
| Beachey, E; Harwell, WB; Lieberman, P; Patterson, JT | 1 |
| Porte, D; Robertson, RP | 1 |
| Curtis-Prior, PB | 1 |
| Kacew, S; Singhal, RL | 1 |
| Beatty, CH; Bocek, RM; Young, MK | 1 |
| Surawicz, B | 1 |
| Barnabei, O; Luly, P; Tomasi, V; Trevisani, A; Tria, E | 1 |
| Morgan, HE; Rannels, SR; Whitfield, CF | 1 |
| Aurbach, GD; Bilezikian, JP; Gardner, JD; Klaeveman, HL | 1 |
| Dryden, EE; Manery, JF; Woo, YT | 1 |
| Blum, JJ | 1 |
| McGuire, J | 1 |
| Brodie, BB; Koppanyi, T; Maling, HM; Saul, W | 1 |
| Blinks, JR; Bravený, P; Jewell, BR; Olson, CB | 1 |
| Chiba, S; Hashimoto, K; Kubota, K | 1 |
| Takagi, K; Takayanagi, I; Tsuchida, Y | 1 |
| Schechter, MD | 1 |
| Fujii, T; Nishimura, H | 2 |
| Friedman, AP | 1 |
| Spilker, BA | 1 |
| Clark, A; Olson, CB | 1 |
| Chiba, S; Hashimoto, K | 2 |
| Morikawa, M | 1 |
| Kawahara, Y; Yamada, S | 1 |
| Bullock, G | 1 |
| Praël, E; Strubelt, O | 1 |
| Bellet, S; DeGuzman, NT; Horstmann, E; Kostis, JB; Roman, LR | 1 |
| Hutchins, DA; Rogers, KJ | 1 |
| Cohen, Y; Lesne, M; Valette, G; Wepierre, J | 1 |
| Shimoyama, T | 1 |
| Saida, K; Van Breemen, C | 1 |
| Chandra, A; Lin, MT; Liu, GG | 1 |
| Niedergerke, R; Page, S | 1 |
| Ito, Y; Itoh, T | 1 |
| Fox, IJ; Swayze, CR; Wahler, GM | 1 |
| Bianchi, M; Sora, S | 1 |
| Alischewski, N; Honerjäger, P | 1 |
| Barrand, MA; Callingham, BA; James, WP; Jung, RT; Shetty, PS | 1 |
| Denison, M; Roberts, RJ; Weesner, KM | 1 |
| Furusawa, S; Sasaki, K; Takayanagi, G | 1 |
| Chaput de Saintonge, DM; Hong, CY; Turner, P | 1 |
| Desmond, PV; Dunn, GD; Hoyumpa, AM; Johnson, RF; Patwardhan, RV; Robertson, DH; Schenker, S | 1 |
| Atanacković, D; Frković, A; Simonić, A | 1 |
| Degtyariov, IG; Dubovick, BV; Pakhomov, AG; Pronkevich, AN | 1 |
| Hogg, RC; Large, WA; Wang, Q | 1 |
| Babey, AM; Palmour, RM; Young, SN | 1 |
| Callaway, CW; Geyer, MA; Rempel, NL | 1 |
| Elgjo, K; Reichelt, KL | 1 |
| Assadi, M; Boutjdir, M; el-Sherif, N | 1 |
| Awh, CC; de Juan, E; Humayun, MU; Pieramici, DJ; Rader, RS | 1 |
| Fryer, MW; Ha, TN | 1 |
| Bjerkås, H; Helle, KB; Lønning, K | 1 |
| Mizojiri, K; Tanaka, H | 1 |
| Saris, WH; Van Baak, MA | 1 |
| Gudme, CN; Nielsen, MS; Nielsen, R | 1 |
| Bers, DM; Li, L; Pogwizd, SM; Schlotthauer, K; Yuan, W | 1 |
| Carcillo, JA; Jackson, EK; Tofovic, SP; Zacharia, L | 1 |
| Chatterjee, S; Kumar, A | 1 |
| Asakawa, N; Ishihama, Y; Murata, K; Yamamoto, E | 1 |
| Graham, TE; Thong, FS | 1 |
| Beller, GA; Glover, DK; Linden, J; Macdonald, TL; Rieger, JM; Riou, LM; Ruiz, M; Watson, DD | 1 |
| Gritti, F; Guiochon, G | 4 |
| Acheson, KJ; Fay, LB; Gay, LJ; Gremaud, G; Krebs, Y; Meirim, I; Montigon, F; Schindler, C; Schneiter, P; Tappy, L | 1 |
| Felinger, A; Gritti, F; Guiochon, G | 1 |
| Heiskanen, M; Ketolainen, J; Lehto, VP; Mäki, R; Murtomaa, M; Rost, S; Suihko, E | 1 |
| Barajas-López, C; Calixto, E; Campos-Bedolla, P; Figueroa, A; Flores-Soto, E; Mendoza-Patiño, N; Montaño, LM; Segura, P; Vargas, MH | 1 |
| Adriaensen, J; Augustijns, P; Brewster, ME; Mackie, C; Melis, A; Mensch, J; Noppe, M | 1 |
| Feng, YQ; Lin, B; Ng, SC; Zheng, MM | 1 |
| Cao, YX; He, JY; He, LC; Zhang, W | 1 |
| Gritti, F; Guiochon, G; Perdu, C | 1 |
| Karlson-Stiber, C; Schmidt, A | 1 |
| Hase, T; Kanazawa, S; Mori, S; Nishizawa, Y; Satou, M; Takema, Y; Tokimitsu, I; Yada, T; Yoshizuka, N | 1 |
| Belza, A; Gille, MB; Kondrup, J; Schultz John, S | 1 |
| Alada, AR; Salahdeen, HM | 1 |
| Chary, NS; Lin, AY; Lin, CA; Tung, HH | 1 |
| Ahmad, H; Lazzaro, D; Liu, M; Pointdujour, R; Smith, E | 1 |
| Kühne, S; Steinert, M; Untucht, C; Wätzig, H | 1 |
| Alonso, E; Aparicio, I; Camacho-Muñoz, MA; Martín, J; Santos, JL | 1 |
| Chan, LW; Heng, PW; Tay, SL | 1 |
| Chen, L; Huang, F; Li, W; Li, X; Liu, Z; Luo, Z; Wu, H; Xu, Y; Young, C; Zhou, S | 1 |
| Kertesz, V; Van Berkel, GJ | 1 |
| Ali, R; Bodmeier, R; Dashevsky, A | 1 |
| Kibbey, TCG; Normile, HJ; Papelis, C | 1 |
| Jacobsen, J; Marxen, E; Mosgaard, MD; Pedersen, AML | 1 |
| Fatibello-Filho, O; Santos, AM; Silva, TA; Wong, A | 1 |
| Andrade, A; Fernandes, M; Pedro, M; Sousa, C | 1 |
| Castaño-Sánchez, A; Di Lorenzo, T; Di Marzio, WD; Galassi, DMP; García-Doncel, P; Iepure, S; Nozal Martínez, L | 1 |
| Bachour, J; Bachour, K; Dagher, M; Ollaik, F | 1 |
| Ali, R; Bodmeier, R; Chaerunisaa, AY; Körber, M | 1 |
| Belfort, R; Dias Gomes Barrios Marin, V; Faber, J; Farah, ME; Gehlbach, PL; Grupenmacher, AT; Jiramongkolchai, K; Maia, M; Muralha, F; Roizenblatt, M | 1 |
| Belfort Junior, R; Dias Gomes Barrios Marin, V; Eid Farah, M; Gehlbach, PL; Jiramongkolchai, K; Maia, M; Muralha, F; Roizenblatt, M; Treiger Grupenmacher, A | 1 |
| Belfort Junior, R; Caiado, R; da Cruz Noia, L; da Silveira Saraiva, V; Eid Farah, M; Fernandes, RAB; Gehlbach, PL; Jiramongkolchai, K; Magalhães Junior, O; Maia, M; Nakanami, MH; Passos, RM; Roizenblatt, M; Stefanini, FR; Watanabe, SES; Wolf, M; Yasaki, ES | 1 |
5 review(s) available for propranolol and caffeine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drugs in pregnancy: effects on the fetus and newborn.
Topics: Analgesics; Anti-Inflammatory Agents; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Antithyroid Agents; Caffeine; Ethanol; Female; Fetus; Hormones; Humans; Hypnotics and Sedatives; Infant, Newborn; Pregnancy; Propranolol; Psychotropic Drugs; Smoking; Teratogens | 1979 |
The diagnostic validity of anxiety disorders and their relationship to depressive illness.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Clonidine; Cross-Sectional Studies; Depressive Disorder; Epinephrine; Follow-Up Studies; Humans; Lactates; Norepinephrine; Panic; Propranolol; Receptors, GABA-A; Research Design | 1985 |
Recent observations on drugs and human fertility.
Topics: Administration, Intravaginal; Caffeine; Calcimycin; Calcium; Cell Membrane Permeability; Contraceptive Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Propranolol; Sperm Maturation; Sperm Motility | 1988 |
Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system.
Topics: Animals; Caffeine; Catecholamines; Cyclic AMP; Diazoxide; Epinephrine; Glucose; Hypothermia; Hypoxia; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Phentolamine; Propranolol; Receptors, Adrenergic; Stress, Physiological; Sympathetic Nervous System; Theophylline | 1973 |
7 trial(s) available for propranolol and caffeine
| Article | Year |
|---|---|
Effect of coffee on exercise-induced angina pectoris due to coronary artery disease in habitual coffee drinkers.
Topics: Adult; Aged; Angina Pectoris; Caffeine; Chronic Disease; Coffee; Coronary Disease; Drinking Behavior; Exercise Test; Humans; Male; Middle Aged; Myocardial Contraction; Propranolol | 1985 |
Quantitative measurement of the effects of caffeine and propranolol on surgeon hand tremor.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Female; Hand; Heart Rate; Humans; Male; Microsurgery; Ophthalmology; Propranolol; Tremor | 1997 |
The effect of caffeine on endurance performance after nonselective beta-adrenergic blockade.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Drug Interactions; Fatty Acids; Humans; Male; Physical Endurance; Potassium; Propranolol | 2000 |
Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?
Topics: Adrenergic beta-Antagonists; Adult; Caffeine; Central Nervous System Stimulants; Energy Metabolism; Humans; Lipid Metabolism; Lipolysis; Male; Oxidation-Reduction; Propranolol; Theophylline | 2004 |
The beta-adrenergic antagonist propranolol partly abolishes thermogenic response to bioactive food ingredients.
Topics: Adrenergic beta-Antagonists; Adult; Basal Metabolism; Blood Pressure; Caffeine; Capsaicin; Catechin; Cross-Over Studies; Double-Blind Method; Heart Rate; Humans; Male; Obesity; Overweight; Propranolol; Thermogenesis; Tyrosine | 2009 |
Association of Weight-Adjusted Caffeine and β-Blocker Use With Ophthalmology Fellow Performance During Simulated Vitreoretinal Microsurgery.
Topics: Adrenergic beta-Antagonists; Adult; Body Mass Index; Caffeine; Central Nervous System Stimulants; Clinical Competence; Computer Simulation; Cross-Sectional Studies; Drug Combinations; Fellowships and Scholarships; Female; Humans; Male; Microsurgery; Ophthalmology; Propranolol; Psychomotor Performance; Single-Blind Method; Vitreoretinal Surgery | 2020 |
Weight-adjusted caffeine and β-blocker use in novice versus senior retina surgeons: a self-controlled study of simulated performance.
Topics: Adrenergic beta-Antagonists; Caffeine; Cross-Sectional Studies; Double-Blind Method; Humans; Male; Propranolol; Retina; Surgeons; Tremor | 2023 |
188 other study(ies) available for propranolol and caffeine
| Article | Year |
|---|---|
Computation of brain-blood partitioning of organic solutes via free energy calculations.
Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics | 1996 |
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.
Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Toward an optimal blood-brain barrier shuttle by synthesis and evaluation of peptide libraries.
Topics: Biological Transport; Blood-Brain Barrier; Cell Survival; Drug Carriers; Humans; Levodopa; Membranes, Artificial; Peptide Library; Peptides; Permeability; Phenylalanine; Solubility | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Biological Transport; Blood Vessels; Blood-Brain Barrier; Brain; Cattle; Cell Membrane Permeability; Cells, Cultured; Chromatography, High Pressure Liquid; Coculture Techniques; Drug Carriers; Endothelial Cells; gamma-Aminobutyric Acid; Mass Spectrometry; Molecular Structure; Nipecotic Acids; Oligopeptides; Phenylalanine; Rats | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
One drug for two targets: Biological evaluation of antiretroviral agents endowed with antiproliferative activity.
Topics: Anti-Retroviral Agents; Cell Survival; Gene Expression; HIV-1; HT29 Cells; Humans; MCF-7 Cells; Microsomes, Liver; Proto-Oncogene Proteins c-myc; Telomerase | 2017 |
Antiangiogenic Activity and Chemical Derivatization of the Neurotoxic Acetogenin Annonacin Isolated from Asimina triloba.
Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Asimina; Capillaries; Fruit; Furans; In Vitro Techniques; Lactones; Molecular Structure; Plant Extracts; Rats; Seeds; Structure-Activity Relationship | 2018 |
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.
Topics: Acetylation; Animals; Catalytic Domain; Cells, Cultured; Crystallography, X-Ray; Histone Deacetylase 6; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; In Vitro Techniques; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Phenothiazines; Structure-Activity Relationship; Zebrafish | 2019 |
Practolol, caffeine and calcium in the regulation of mechanical activity of the cardiac ventricle in Myxine glutinosa (L.).
Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Fishes; Hagfishes; Heart Ventricles; Hydroxydopamines; Myocardial Contraction; Phenoxybenzamine; Phentolamine; Practolol; Propranolol; Reserpine; Theophylline; Ventricular Function | 1975 |
Pharmacological interactions with circling behaviour induced by the piperidinyl indole derivative RU 23686.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Caffeine; Drug Interactions; Haloperidol; Humans; Indoles; Male; Methyltyrosines; Methysergide; Motor Activity; Neurotransmitter Agents; Nialamide; Phenoxybenzamine; Propranolol; Rats; Reserpine; Scopolamine; Stereotyped Behavior | 1977 |
Inhibition of potassium uptake by low concentrations of norepinephrine and dibutyryl cyclic AMP.
Topics: Aminophylline; Animals; Biological Transport, Active; Bucladesine; Caffeine; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Heart Conduction System; Imidazoles; Magnesium; Norepinephrine; Phentolamine; Potassium; Potassium Radioisotopes; Propranolol; Purkinje Fibers; Xanthines | 1975 |
Epidermal chalone and cyclic AMP: an in vivo study.
Topics: Animals; Autoradiography; Caffeine; Cell Division; Cyclic AMP; Depression, Chemical; DNA; Drug Synergism; Female; Freeze Drying; Growth Inhibitors; Male; Mice; Mitosis; Propranolol; Skin; Thymidine; Tissue Extracts; Tritium; Water | 1975 |
Bronchodilator drug efficacy via cyclic AMP.
Topics: Animals; Bronchodilator Agents; Caffeine; Cyclic AMP; Ephedrine; Epinephrine; Isoproterenol; Lung; Norepinephrine; Phentolamine; Propranolol; Rats; Theophylline | 1975 |
Characterization of lipolytic responses of isolated white adipocytes from hamsters.
Topics: Adenosine; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Caffeine; Catecholamines; Cricetinae; Dose-Response Relationship, Drug; Glycerol; Insulin; Lipid Mobilization; Male; Nicotinic Acids; Norepinephrine; Phentolamine; Propranolol; Prostaglandins E | 1977 |
[Pathogenesis of creatinuria and aminoaciduria in neuromuscular diseases].
Topics: Adolescent; Adult; Amino Acids; Amyotrophic Lateral Sclerosis; Caffeine; Child; Child, Preschool; Creatine; Cyclic AMP; Facial Muscles; Female; Humans; Male; Middle Aged; Muscular Atrophy; Muscular Dystrophies; Neuromuscular Diseases; Propranolol; Shoulder; Syndrome | 1977 |
Effect of two phosphodiesterase inhibitors, cyclic adenosine 3':5'-monophosphate, and a beta-blocking agent on human sperm motility.
Topics: Adolescent; Adult; Bucladesine; Caffeine; Humans; Male; Pentoxifylline; Propranolol; Sperm Motility; Theobromine; Time Factors | 1978 |
[Adrenergic regulation of thermogenesis in Siberian lemmings].
Topics: Animals; Body Temperature; Body Temperature Regulation; Caffeine; Drug Interactions; Isoproterenol; Norepinephrine; Oxygen Consumption; Propranolol; Receptors, Adrenergic, beta; Rodentia; Sympathetic Nervous System | 1979 |
Turnover of adenosine 3':5'-cyclic monophosphate in chicken erythrocytes.
Topics: Adenosine Triphosphate; Animals; Caffeine; Chickens; Cyclic AMP; Epinephrine; Erythrocytes; Half-Life; In Vitro Techniques; Kinetics; Propranolol | 1979 |
Potentiating effect of beta-adrenergic stimulant on the response of the cutaneous vascular resistance to alpha-adrenergic stimulant.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Arteries; Bucladesine; Caffeine; Drug Synergism; Imidazoles; In Vitro Techniques; Isoproterenol; Methoxamine; Norepinephrine; Propranolol; Rabbits; Skin; Stimulation, Chemical; Tetracaine; Vascular Resistance | 1975 |
Behavioral side effects of medical drugs.
Topics: Adrenal Cortex Hormones; Aged; Antihypertensive Agents; Antitubercular Agents; Aspirin; Behavior; Caffeine; Cimetidine; Contraceptives, Oral, Hormonal; Digitalis Glycosides; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Levodopa; Male; Mental Disorders; Parasympatholytics; Placebos; Propranolol; Psychoses, Substance-Induced; Reserpine; Sympathomimetics; Thyroid Hormones | 1979 |
Effects of cardioactive substances on the post-stimulation potentiation of contractility in the isolated dog atrium.
Topics: Adenosine; Animals; Caffeine; Chlorides; Dogs; Electric Stimulation; Female; In Vitro Techniques; Male; Manganese; Myocardial Contraction; Ouabain; Pentobarbital; Propranolol; Tetrodotoxin; Verapamil | 1978 |
Inhibition of the electrical and mechanical activities of the intestinal smooth muscle by pentagastrin.
Topics: Action Potentials; Animals; Caffeine; Cats; Epinephrine; Gastrointestinal Motility; Imidazoles; In Vitro Techniques; Intestine, Small; Muscle, Smooth; Pentagastrin; Propranolol; Tetragastrin | 1978 |
Drugs for migraine.
Topics: Caffeine; Clonidine; Drug Synergism; Ergotamine; Heart Valve Diseases; Humans; Methysergide; Migraine Disorders; Mitral Valve Insufficiency; Propranolol; Pulmonary Fibrosis | 1976 |
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myocarditis; Myocardium; Necrosis; Oxygen Consumption; Propranolol; Rats; Theophylline; Verapamil | 1976 |
Mitigation of caffeine-induced fetopathy in mice by pretreatment with beta-adrenergic blocking agents.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Female; Fetus; Mice; Mice, Inbred ICR; Pregnancy; Propanolamines; Propranolol; Time Factors; Timolol | 1976 |
Insulin biosynthesis: the monoaminergic mechanisms and the specificity of "glucoreceptor".
Topics: Amines; Animals; Caffeine; Dopamine; Fructose; Galactose; Glucosamine; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Isoproterenol; Leucine; Male; Propranolol; Rats; Receptors, Drug; Serotonin; Sorbitol | 1975 |
[Sympatholytic therapy of paralytic ileus].
Topics: Caffeine; Catecholamines; Chlorpromazine; Drug Therapy, Combination; Humans; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Parasympathomimetics; Propranolol; Sympatholytics; Trifluperidol | 1975 |
Beta-adrenergic regulation of a myocardial actin gene via a cyclic AMP-independent pathway.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Actins; Animals; Animals, Newborn; Blotting, Northern; Bucladesine; Caffeine; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Enkephalins; Gene Expression Regulation; Heart; Heart Ventricles; Isoproterenol; Kinetics; Myocardium; Nifedipine; Potassium Chloride; Propranolol; Protein Precursors; Rats; Receptors, Adrenergic, beta; RNA; RNA, Messenger; Ryanodine | 1992 |
Separate sites for the dantrolene-induced inhibition of contracture of the rat diaphragm preparation due to depolarization or to caffeine.
Topics: Animals; Caffeine; Dantrolene; Diaphragm; Dicumarol; Drug Interactions; Drug Synergism; Ethylmaleimide; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Propranolol; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Abnormal Cai2+ handling is the primary cause of mechanical alternans: study in ferret ventricular muscles.
Topics: Action Potentials; Aequorin; Animals; Caffeine; Calcium; Carbachol; Electric Stimulation; Ferrets; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Propranolol; Ryanodine; Sarcoplasmic Reticulum | 1991 |
Load-dependent left ventricular relaxation in conscious dogs.
Topics: Animals; Blood Pressure; Caffeine; Dogs; Heart Rate; Heart Ventricles; Hemodynamics; Myocardial Contraction; Propranolol; Regression Analysis; Verapamil | 1991 |
Effects of propranolol and caffeine on movement characteristics of human sperm.
Topics: Caffeine; Humans; In Vitro Techniques; Male; Propranolol; Random Allocation; Sperm Motility; Videotape Recording | 1990 |
Inhibition of porcine adipose tissue lipogenesis by beta-adrenergic agonists.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adipose Tissue; Adrenergic beta-Agonists; Animals; Caffeine; Drug Interactions; Epinephrine; Isoproterenol; Lipids; Male; Propranolol; Swine; Theophylline | 1989 |
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors.
Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil; Motor Activity; Muscle Relaxants, Central; Norepinephrine; Propranolol; Receptors, Adrenergic; Receptors, GABA-A; Receptors, Purinergic; Social Behavior | 1989 |
Role of calcium in caffeine-norepinephrine interactions in cardiac Purkinje fibers.
Topics: Animals; Caffeine; Calcium; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Glycolysis; Heart Conduction System; Male; Methoxamine; Myocardial Contraction; Norepinephrine; Potassium; Propranolol; Purkinje Fibers; Theophylline | 1989 |
Influence of propranolol on the in vitro response to caffeine and halothane in malignant hyperthermia-susceptible muscle.
Topics: Anesthesia; Caffeine; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Interactions; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscles; Propranolol | 1989 |
Changes in cyclic AMP and cyclic GMP levels in the contraction-relaxation cycle of isolated smooth muscle cells from guinea-pig taenia caeci.
Topics: Animals; Caffeine; Colon; Cyclic AMP; Cyclic GMP; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Propranolol | 1985 |
Regulation of energy expenditure in brown adipose tissue.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Body Temperature Regulation; Bucladesine; Caffeine; Cold Temperature; Dose-Response Relationship, Drug; Energy Metabolism; Female; Hyperphagia; Models, Biological; Norepinephrine; Oxygen Consumption; Palmitic Acid; Palmitic Acids; Physical Exertion; Propranolol; Rats; Rats, Inbred Strains; Temperature; Theophylline | 1985 |
Attentional effects of caffeine in man: comparison with drugs acting upon performance.
Topics: Albuterol; Arousal; Attention; Caffeine; Humans; Propranolol; Word Association Tests | 1988 |
Birth defects following maternal exposure to ergotamine, beta blockers, and caffeine.
Topics: Abnormalities, Drug-Induced; Caffeine; Ergotamine; Female; Humans; Infant, Newborn; Migraine Disorders; Pregnancy; Pregnancy Complications; Propranolol | 1988 |
Beta-adrenoceptor blocking drugs and cytochrome P-450: the influence of propranolol treatment on caffeine, antipyrine, D-glucaric acid and indocyanine green elimination in patients with hepatic disorders.
Topics: Adult; Antipyrine; Caffeine; Cytochrome P-450 Enzyme System; Female; Glucaric Acid; Humans; Indocyanine Green; Liver Diseases, Alcoholic; Male; Middle Aged; Propranolol | 1986 |
Effects of (+)-propranolol on intracellular mechanisms of contraction in striated muscle of the rabbit.
Topics: Animals; Caffeine; Calcium; Carrier Proteins; Contractile Proteins; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscles; Myocardial Contraction; Propranolol; Protein Binding; Rabbits; Sarcoplasmic Reticulum; Troponin; Troponin C | 1985 |
Caffeine inhibits the central hypotensive action of propranolol in rats.
Topics: Animals; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Female; Injections; Propranolol; Rats; Rats, Inbred Strains | 1985 |
Control mechanisms of antigen-induced histamine release from rat peritoneal cells.
Topics: Aminophylline; Animals; Antigens; Caffeine; Cardiolipins; Dinitrophenols; Ethanolamines; Hemocyanins; Histamine Release; Isoproterenol; Mast Cells; Ovalbumin; Palmitic Acids; Peritoneum; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Propranolol; Rats; Serum Albumin, Bovine | 1973 |
Effect of - and -adrenergic blocking agents and para-chlorophenylalanine on morphine- and caffeine-stimulated locomotor activity of mice.
Topics: Adrenergic beta-Antagonists; Animals; Caffeine; Drug Antagonism; Ethanolamines; Female; Fenclonine; Locomotion; Male; Mice; Morphine; Motor Activity; Nitrobenzenes; Phenethylamines; Phenoxybenzamine; Propranolol | 1973 |
The role of cyclic 3',5'-adenosine monophosphate in neuromuscular transmission.
Topics: Acetylcholine; Action Potentials; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminophylline; Bronchial Neoplasms; Caffeine; Calcium; Carcinoma; Cyclic AMP; Epinephrine; Humans; Injections, Intravenous; Isoproterenol; Muscles; Muscular Diseases; Myasthenia Gravis; Neuromuscular Junction; Phentolamine; Phenylephrine; Propranolol; Synaptic Transmission; Syndrome | 1973 |
Proceedings: The effect of an H2-receptor antagonist on histamine-stimulated acid secretion by rat stomach in vitro.
Topics: Animals; Caffeine; Gastric Juice; Histamine; Histamine H1 Antagonists; Imidazoles; In Vitro Techniques; Isoproterenol; Pentagastrin; Propranolol; Rats; Reserpine; Secretory Rate; Stimulation, Chemical; Thiourea | 1973 |
The effects of verapamil on metabolism and contractility of the toad skeletal muscle.
Topics: Acetylcholine; Animals; Bufo marinus; Caffeine; Calcium; Dinitrophenols; In Vitro Techniques; Muscle Contraction; Muscles; Oxygen Consumption; Potassium; Procaine; Propranolol; Succinylcholine; Tubocurarine; Verapamil | 1973 |
Effect of inotropic agents on canine trabecular muscle rendered highly permeable to calcium.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Caffeine; Calcium; Cell Membrane Permeability; Depression, Chemical; Dogs; Edetic Acid; Heart Ventricles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Ouabain; Propranolol; Stimulation, Chemical | 1973 |
[Influence of reserpine, propranolol, hexamethonium and adrenalectomy on the chronotropic actions of theophylline and caffeine].
Topics: Animals; Atrial Function; Caffeine; Depression, Chemical; Heart Atria; Heart Rate; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Propranolol; Rats; Reserpine; Tachycardia; Theophylline | 1968 |
[The participation of endogenous catecholamines in the pharmacological effects of theophylline and caffeine].
Topics: Animals; Caffeine; Catecholamines; Hexamethonium Compounds; Propranolol; Rats; Reserpine; Theophylline | 1968 |
Structural and functional characterization of dog heart microsomes.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Caffeine; Calcium; Cytoplasm; Dogs; Electron Transport Complex IV; Heart; Methoxamine; Microscopy, Electron; Microsomes; Mitochondria, Muscle; Muscle Proteins; Muscles; Myocardium; Oxygen Consumption; Propranolol; Succinates; Tetracaine | 1969 |
Platelet aggregation. 3. An epinephrine induced decrease in cyclic AMP synthesis.
Topics: Adenine Nucleotides; Blood Platelets; Caffeine; Carbon Isotopes; Cell Membrane; Cyclic AMP; Drug Antagonism; Epinephrine; Humans; Models, Chemical; Nucleosides; Phentolamine; Platelet Adhesiveness; Propranolol; Prostaglandins | 1970 |
Interactions of xanthine derivatives, catecholamines and glucose-6-phosphate on the isolated phrenic nerve diaphragm preparation of the rat.
Topics: Aminophylline; Animals; Caffeine; Cyclic AMP; Diaphragm; Hexosephosphates; In Vitro Techniques; Muscle Contraction; Neostigmine; Neuromuscular Junction; Norepinephrine; Phrenic Nerve; Propranolol; Rats; Stimulation, Chemical | 1971 |
The effect of PGE-1 on cyclic AMP and ion movements in turkey erythrocytes.
Topics: Animals; Biological Transport; Caffeine; Calcium; Calcium Chloride; Calcium Isotopes; Cattle; Chlorpromazine; Cyclic AMP; Depression, Chemical; Drug Synergism; Epinephrine; Erythrocytes; Guinea Pigs; Half-Life; Humans; Metabolism; Propranolol; Prostaglandins; Rabbits; Rats; Sodium; Sodium Isotopes; Stimulation, Chemical; Time Factors; Turkeys | 1971 |
[Experimental studies on the mode of action of substances promoting radioresistance].
Topics: Adenylyl Cyclases; Animals; Caffeine; Cyclic AMP; Drug Interactions; Female; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Phentolamine; Propranolol; Radiation Injuries, Experimental; Radiation-Protective Agents; Radiotherapy Dosage; Receptors, Drug | 1972 |
Cyclic-AMP in the aqueous humor: the effects of adrenergic agents.
Topics: Aminophylline; Animals; Aqueous Humor; Caffeine; Ciliary Body; Cornea; Cyclic AMP; Epinephrine; Intraocular Pressure; Iris; Isoproterenol; Male; Norepinephrine; Phenoxybenzamine; Propranolol; Rabbits; Retina; Stimulation, Chemical; Sympatholytics; Sympathomimetics; Theophylline | 1972 |
Platelet aggregation in atopic and normal patients.
Topics: Asthma; Bacterial Proteins; Caffeine; Cyclic AMP; Epinephrine; Humans; Hypersensitivity, Immediate; Phentolamine; Platelet Adhesiveness; Propranolol; Rhinitis, Allergic, Seasonal; Skin Tests; Streptococcus | 1973 |
Action of propranolol on lipolysis induced by catecholamine, dibutyryl cyclic AMP and serum.
Topics: Adipose Tissue; Animals; Bucladesine; Caffeine; Catecholamines; Cells; Epinephrine; Immune Sera; In Vitro Techniques; Lipid Metabolism; Male; Norepinephrine; Propranolol; Rats; Theophylline | 1973 |
Effect of certain halogenated hydrocarbon insecticides on cyclic adenosine 3',5'-monophosphate-3H formation by rat kidney cortex.
Topics: Adenosine; Adenylyl Cyclases; Animals; Caffeine; Chlordan; Cyclic AMP; DDT; Dieldrin; Dose-Response Relationship, Drug; Drug Synergism; Endrin; Heptachlor; Hydrazines; Imidazoles; Insecticides; Kidney Cortex; Male; Phosphoric Diester Hydrolases; Propranolol; Prostaglandins; Rats; Tritium | 1974 |
Effect of prostaglandins and epinephrine on the level of cyclic AMP-14C of smooth muscle from the rhesus monkey.
Topics: Adenylyl Cyclases; Animals; Caffeine; Carbon Radioisotopes; Colon; Cyclic AMP; Depression, Chemical; Epinephrine; Female; Haplorhini; In Vitro Techniques; Macaca; Muscle, Smooth; Pregnancy; Propranolol; Prostaglandins; Stimulation, Chemical; Uterus | 1973 |
Editorial: Calcium responses ("calcium spikes").
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Caffeine; Calcium; Coronary Disease; Cyclic AMP; Epinephrine; Heart Arrest; Heart Conduction System; Humans; Isoproterenol; Lanthanum; Manganese; Myocardial Infarction; Potassium; Propranolol; Tetrodotoxin | 1974 |
Modulation by cyclic AMP in vitro of liver plasma membrane (Na+--K+)-ATPase and protein kinases.
Topics: Adenosine Triphosphatases; Animals; Bucladesine; Butyrates; Caffeine; Cell Membrane; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Cytosine Nucleotides; Cytosol; Epinephrine; Kinetics; Liver; Magnesium; Male; Nucleotides, Cyclic; Potassium; Propranolol; Protein Kinases; Sodium; Theophylline | 1974 |
Acceleration of sugar transport in avian erythrocytes by catecholamines.
Topics: Adenosine Triphosphate; Animals; Caffeine; Carbon Radioisotopes; Catechols; Cell Membrane; Cyclic AMP; Desipramine; Dopamine; Ephedrine; Epinephrine; Erythrocytes; Galactose; Geese; Glucose; Iproniazid; Isoproterenol; Methylglycosides; Norepinephrine; Phentolamine; Phloretin; Potassium; Propranolol; Sorbitol; Stereoisomerism | 1974 |
Stimulation of sodium transport in turkey erythrocytes by cyclic 3',5'-AMP.
Topics: Adenylyl Cyclases; Animals; Biological Transport, Active; Bucladesine; Caffeine; Cell Membrane; Cyclic AMP; Enzyme Activation; Erythrocytes; Isoproterenol; Phosphoric Diester Hydrolases; Propranolol; Sodium; Theophylline; Time Factors; Tritium; Turkeys; Xanthines | 1974 |
Theophylline inhibition of nucleoside transport and its relation to cyclic AMP in skeletal muscle.
Topics: Adenine; Adenosine; Animals; Biological Transport; Bucladesine; Caffeine; Carbon Radioisotopes; Chromatography, Paper; Cyclic AMP; Hypoxanthines; In Vitro Techniques; Inosine; Isoproterenol; Muscle Contraction; Muscles; Nucleosides; Phenytoin; Propranolol; Protein Binding; Purines; Rana pipiens; Ribose; Sorbitol; Theophylline; Tritium; Uridine | 1974 |
An adrenergic control system in Tetrahymena.
Topics: Caffeine; Catecholamines; Desipramine; Glycogen; Hydrazines; Isoproterenol; Phenoxybenzamine; Propranolol; Reserpine; Tetrahymena; Triiodothyronine | 1967 |
Adrenergic control of melanocytes.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenocorticotropic Hormone; Animals; Anura; Caffeine; Catecholamines; Chromatophores; Cyclic AMP; Epinephrine; In Vitro Techniques; Isoproterenol; Melanins; Melanocyte-Stimulating Hormones; Melanocytes; Phenylephrine; Pigmentation; Propranolol; Skin; Tolazoline | 1970 |
Jumping activity induced by sodium 5-(1,3-dimethylbutyl)-5-ethyl barbiturate. I. The role of the sympathetic nervous system.
Topics: Adrenergic beta-Antagonists; Amino Alcohols; Amobarbital; Animals; Anticonvulsants; Barbiturates; Benzazepines; Blood Glucose; Body Temperature; Brain Chemistry; Caffeine; Chlordiazepoxide; Chlorisondamine; Dextroamphetamine; Diazepam; Drug Synergism; Fatty Acids, Nonesterified; Male; Mice; Motor Activity; Pempidine; Pentobarbital; Pentylenetetrazole; Phentolamine; Propranolol; Sympathetic Nervous System | 1970 |
Influence of caffeine and other methylxanthines on mechanical properties of isolated mammalian heart muscle. Evidence for a dual mechanism of action.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Atropine; Caffeine; Calcium; Calcium Isotopes; Cats; Electric Stimulation; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Norepinephrine; Papillary Muscles; Procaine; Propranolol; Reserpine; Strontium; Strontium Isotopes; Theobromine; Theophylline; Time Factors | 1972 |
Double peaked positive chronotropic response of the isolated blood-perfused S-A node to caffeine.
Topics: Adrenergic beta-Antagonists; Animals; Blood; Caffeine; Depression, Chemical; Dogs; Heart Rate; In Vitro Techniques; Perfusion; Propranolol; Sinoatrial Node; Stimulation, Chemical; Tetrodotoxin | 1972 |
The effects of caffeine and imidazole on the actions of beta- and alpha-adrenergic stimulants, papaverine and cyclic 3', 5'-AMP.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Caffeine; Colon; Cyclic AMP; Depression, Chemical; Dibenzylchlorethamine; Drug Synergism; Epinephrine; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Papaverine; Phenylephrine; Propranolol; Stimulation, Chemical | 1972 |
Effect of propranolol, d-amphetamine and caffeine on ethanol as a discriminative cue.
Topics: Animals; Behavior, Animal; Caffeine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Female; Propranolol; Rats | 1974 |
Reduction in frequency of fetopathic effects of caffeine in mice by pretreatment with propranolol.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Catecholamines; Female; Fetus; Humans; Maternal-Fetal Exchange; Mice; Mice, Inbred ICR; Pregnancy; Propranolol; Teratogens | 1974 |
Proceedings: Prevention of embryopathic effects of caffeine in mice by pretreatment with propranolol.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Embryo, Mammalian; Female; Humans; Mice; Pregnancy; Propranolol | 1974 |
Migraine headaches.
Topics: Caffeine; Contraceptives, Oral; Cyproheptadine; Diagnosis, Differential; Diuretics; Drug Combinations; Ergotamine; Humans; Methysergide; Migraine Disorders; Monoamine Oxidase Inhibitors; Personality; Propranolol; Recurrence; Stress, Physiological; Substance Withdrawal Syndrome; Tranquilizing Agents | 1972 |
A comparative description of inotropic agents in vitro.
Topics: Animals; Caffeine; Calcium; Cats; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Glucagon; Guinea Pigs; Heart; Heart Atria; Histamine; In Vitro Techniques; Manganese; Muscle Contraction; Muscle, Smooth; Norepinephrine; Ouabain; Papillary Muscles; Propranolol; Rabbits; Reserpine; Serotonin; Temperature; Theophylline; Time Factors | 1973 |
Effects of caffeine and isoprenaline on mammalian ventricular muscle.
Topics: Action Potentials; Animals; Caffeine; Cats; Drug Interactions; Electric Stimulation; Heart Ventricles; In Vitro Techniques; Isoproterenol; Membrane Potentials; Papillary Muscles; Propranolol; Time Factors | 1973 |
Antagonism between manganese and caffeine on the SA node of the dog heart in situ.
Topics: Animals; Caffeine; Calcium; Dogs; Manganese; Norepinephrine; Propranolol; Sinoatrial Node; Stimulation, Chemical; Tetrodotoxin | 1973 |
[Effect of various drugs on metabolism of skeletal muscles. 3. Effect of cholinergic, cholinesterase inhibitor and neuromuscular blocking agents on oxygen consumption of the skeletal musscles].
Topics: Animals; Caffeine; Carbachol; Cholinesterase Inhibitors; Fluorenes; In Vitro Techniques; Muscles; Neostigmine; Neuromuscular Depolarizing Agents; Oxygen Consumption; Parasympathomimetics; Phentolamine; Physostigmine; Potassium; Propranolol; Quaternary Ammonium Compounds; Ranidae; Succinylcholine; Tubocurarine | 1973 |
[Pharmacological studies on the vascular system of the human placenta].
Topics: Acetylcholine; Atropine; Blood Vessels; Caffeine; Carbon Dioxide; Ephedrine; Epinephrine; Ergotamine; Female; Histamine; Humans; Isoproterenol; Nicotine; Norepinephrine; Oxygen; Oxytocin; Papaverine; Perfusion; Phenoxybenzamine; Pilocarpine; Placenta; Pregnancy; Propranolol; Quinine; Serotonin | 1974 |
Pharmacological analysis of chronotropic responses of the S-A node to caffeine.
Topics: Alprenolol; Amino Alcohols; Animals; Blood Pressure; Caffeine; Dogs; Electrocardiography; Female; Isoproterenol; Male; Norepinephrine; Perfusion; Propranolol; Sinoatrial Node; Sympatholytics; Tetrodotoxin | 1972 |
Prize winners in the RMS micrograph competition. First prize: the visual response of rat diaphragm muscle to different classes of drugs.
Topics: Anesthetics, Local; Anilides; Animals; Caffeine; Diaphragm; Glutarates; Microscopy, Electron; Mitochondrial Swelling; Muscles; Oligomycins; Perfusion; Pipecolic Acids; Propranolol; Rats | 1972 |
[Pharmacological effects on the contraction frequency of isolated rat portal vein].
Topics: Aconitum; Animals; Atropine; Caffeine; Carbachol; Epinephrine; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Nitrites; Norepinephrine; Papaverine; Peptides; Phentolamine; Portal Vein; Propranolol; Quinidine; Rats; Rats, Inbred Strains; Reserpine; Strophanthins; Theophylline; Tyramine | 1972 |
Effect of caffeine on the ventricular fibrillation threshold in normal dogs and dogs with acute myocardial infarction.
Topics: Animals; Benzoates; Caffeine; Dogs; Heart; Myocardial Infarction; Propranolol; Sodium; Ventricular Fibrillation | 1972 |
The influence of reserpine, propranolol, and adrenal medullectomy on the hyperglycemic actions of theophylline and caffeine.
Topics: Adrenal Medulla; Aminophylline; Animals; Blood Glucose; Body Temperature; Caffeine; Male; Propranolol; Rats; Reserpine; Stimulation, Chemical; Theophylline; Time Factors | 1969 |
Physiological and drug-induced changes in the glycogen content of mouse brain.
Topics: Amphetamine; Animals; Bemegride; Body Temperature; Brain Chemistry; Caffeine; Catecholamines; Circadian Rhythm; Diphenhydramine; Glucose; Glycogen; Hyperglycemia; Insulin; Male; Mice; Motor Activity; Nialamide; Phenytoin; Propranolol; Seizures; Temperature | 1970 |
[Study of the mechanism of the positive inotropic effect exercised by methylxanthines on the isolated perfused rat heart].
Topics: Animals; Caffeine; Cardiac Output; Drug Antagonism; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Methods; Norepinephrine; Propranolol; Rats; Reserpine; Theophylline; Xanthines | 1970 |
[Studies on the site of action of drugs in single muscle fibers of frog skeletal muscle].
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anura; Binding Sites; Caffeine; Calcium Chloride; Dopamine; Imidazoles; Isoproterenol; Methylene Blue; Muscle Contraction; Muscles; Norepinephrine; Potassium Chloride; Propranolol; Sodium Chloride; Strophanthins; Tubocurarine; Tyramine; Veratrine | 1968 |
[Participation of endogenous catecholamines on the effect of coffee on energy conversion and heart frequency].
Topics: Animals; Caffeine; Carbon Dioxide; Catecholamines; Coffee; Electrocardiography; Heart Rate; Male; Oxygen Consumption; Propranolol; Rats; Reserpine; Stimulation, Chemical | 1968 |
[On the mechanism of the calorigenic effect of theophylline and caffeine].
Topics: Adrenal Medulla; Adrenalectomy; Anesthesia; Animals; Caffeine; Calorimetry; Epinephrine; Oxygen Consumption; Propranolol; Rats; Reserpine; Theophylline; Wakefulness | 1969 |
Cyclic AMP modulation of adrenoreceptor-mediated arterial smooth muscle contraction.
Topics: Animals; Bucladesine; Caffeine; Calcium; Cyclic AMP; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Norepinephrine; Propranolol; Rabbits; Receptors, Adrenergic; Sarcoplasmic Reticulum | 1984 |
The effects of theophylline and caffeine on thermoregulatory functions of rats at different ambient temperatures.
Topics: Animals; Body Temperature Regulation; Caffeine; Drug Interactions; Haloperidol; Hydroxydopamines; Male; Phentolamine; Propranolol; Rats; Temperature; Theophylline | 1980 |
Two physiological agents that appear to facilitate calcium discharge from the sarcoplasmic reticulum in frog heart cells: adrenalin an ATP.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Epinephrine; Heart; Propranolol; Rana temporaria; Sarcoplasmic Reticulum; Time Factors | 1981 |
The roles of stored calcium in contractions of cat tracheal smooth muscle produced by electrical stimulation, acetylcholine and high K+.
Topics: Acetylcholine; Animals; Atropine; Caffeine; Calcium; Cats; Egtazic Acid; Electric Stimulation; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuroeffector Junction; Potassium; Procaine; Propranolol; Tetraethylammonium Compounds; Tetrodotoxin; Trachea | 1984 |
A Ca2+-dependent mechanism for the positive inotropic response to an increase in afterload in cat papillary muscle.
Topics: Animals; Aorta; Blood Pressure; Caffeine; Calcium; Cats; Heart; Heart Rate; In Vitro Techniques; Isometric Contraction; Isotonic Contraction; Myocardial Contraction; Papillary Muscles; Propranolol; Temperature; Verapamil | 1984 |
Propranolol, atenolol, and trifluoperazine reduce the spontaneous occurrence of meiotic diploid products in Saccharomyces cerevisiae.
Topics: Atenolol; Caffeine; Diploidy; Propanolamines; Propranolol; Saccharomyces cerevisiae; Spores, Fungal; Trifluoperazine | 1982 |
Inotropic and electrophysiological effects of dantrolene on guinea-pig papillary muscle.
Topics: Action Potentials; Animals; Caffeine; Calcium; Dantrolene; Depression, Chemical; Female; Guinea Pigs; Male; Myocardial Contraction; Ouabain; Papillary Muscles; Propranolol; Reserpine; Ryanodine; Stimulation, Chemical; Tetrodotoxin | 1983 |
Caffeine: its effect on catecholamines and metabolism in lean and obese humans.
Topics: Adult; Blood Glucose; Body Temperature Regulation; Caffeine; Catecholamines; Fatty Acids, Nonesterified; Female; Glycerol; Humans; Insulin; Obesity; Propranolol | 1981 |
Cardiac arrhythmias in an adolescent following ingestion of an over-the-counter stimulant.
Topics: Adolescent; Arrhythmias, Cardiac; Caffeine; Ephedrine; Female; Humans; Nonprescription Drugs; Phenylpropanolamine; Propranolol | 1982 |
Effect of prior administration of aminophylline, caffeine, or propranolol on the antitumor activity of 6-mercaptopurine or 6-mercaptopurine riboside.
Topics: Aminophylline; Animals; Antineoplastic Agents; Caffeine; Drug Interactions; Inosine; Male; Mercaptopurine; Mice; Propranolol; Thioinosine | 1981 |
The inhibitory action of procaine, (+)-propranolol and (+/-)-propranolol on human sperm motility: antagonism by caffeine.
Topics: Caffeine; Humans; Male; Procaine; Propranolol; Sperm Motility | 1981 |
Effects of caffeine on plasma free fatty acids, urinary catecholamines, and drug binding.
Topics: Blood Proteins; Caffeine; Catecholamines; Chlordiazepoxide; Diazepam; Drug Interactions; Fatty Acids, Nonesterified; Female; Humans; Male; Pharmaceutical Preparations; Propranolol; Protein Binding | 1980 |
[The mechanism of the chronotropic effect of caffeine and theophylline in guinea pigs].
Topics: Animals; Caffeine; Guinea Pigs; Heart Rate; In Vitro Techniques; Methyldopa; Propranolol; Reserpine; Theophylline | 1980 |
Microwave influence on the isolated heart function: II. Combined effect of radiation and some drugs.
Topics: Animals; Atropine; Caffeine; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Microwaves; Myocardial Contraction; Propranolol; Rana temporaria; Time Factors | 1995 |
Action of niflumic acid on evoked and spontaneous calcium-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Caffeine; Calcium; Chloride Channels; Electrophysiology; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niflumic Acid; Norepinephrine; Portal Vein; Potassium Channels; Propranolol; Rabbits | 1994 |
Caffeine and propranolol block the increase in rat pineal melatonin production produced by stimulation of adenosine receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Binding, Competitive; Caffeine; Caudate Nucleus; Circadian Rhythm; Male; Melatonin; Pineal Gland; Propranolol; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Vasodilator Agents | 1994 |
Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Caffeine; Designer Drugs; Dopamine Agents; Dose-Response Relationship, Drug; Fluoxetine; Indoles; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Scopolamine; Serotonin; Serotonin Receptor Agonists; Synapses | 1993 |
Beta-receptor blockade by propranolol modifies the effect of the inhibitory, endogenous epidermal pentapeptide on epidermal cell flux at the G2-M transition but not at the G1-S transition.
Topics: Amino Acid Sequence; Animals; Caffeine; Cyclic AMP; Epidermal Cells; Epidermis; Female; Interphase; Mice; Mice, Hairless; Mitosis; Molecular Sequence Data; Oligopeptides; Propranolol; Pyrrolidonecarboxylic Acid | 1994 |
Electrophysiologic effects of cocaine on subendocardial Purkinje fibers surviving 1 day of myocardial infarction.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Caffeine; Calcium; Central Nervous System Stimulants; Cocaine; Computers; Dogs; Endocardium; In Vitro Techniques; Microelectrodes; Myocardial Infarction; Propranolol; Purkinje Fibers | 1995 |
Inhibitory effects of (+/-)-propranolol on excitation-contraction coupling in isolated soleus muscles of the rat.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Caffeine; Electric Stimulation; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Skeletal; Potassium; Propranolol; Rats; Rats, Wistar | 1997 |
The adrenomedullary venous vasculature as a target for endothelins: comparison of the porcine and bovine central adrenomedullary veins.
Topics: Acetylcholine; Adenylyl Cyclases; Adrenal Medulla; Animals; Caffeine; Cattle; Colforsin; Cyclic AMP; Endothelin-1; Milrinone; Muscle, Smooth, Vascular; Neuropeptide Y; Potassium; Propranolol; Receptor, Endothelin A; Receptors, Endothelin; Second Messenger Systems; Species Specificity; Swine; Vasoactive Intestinal Peptide; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Veins | 1998 |
Drug-protein binding and blood-brain barrier permeability.
Topics: Animals; Benzodiazepines; Blood-Brain Barrier; Bridged Bicyclo Compounds; Caffeine; Calcium Channel Blockers; Diazepam; Dihydropyridines; Fatty Acids, Monounsaturated; Male; Microcirculation; Models, Biological; Nootropic Agents; Perfusion; Permeability; Pharmaceutical Preparations; Propranolol; Prosencephalon; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Serum Albumin, Bovine | 1999 |
Effect of alpha1-adrenergic stimulation of Cl- secretion and signal transduction in exocrine glands (Rana esculenta).
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Biological Transport; Caffeine; Calcium; Chlorides; Cyclic AMP; Dose-Response Relationship, Drug; Exocrine Glands; Female; Fluorescent Dyes; Fura-2; Inositol 1,4,5-Trisphosphate; Male; Norepinephrine; Phosphodiesterase Inhibitors; Prazosin; Propranolol; Rana esculenta; Receptors, Adrenergic, alpha-1; Ryanodine; Signal Transduction; Skin Physiological Phenomena | 2000 |
Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Caffeine; Calcium; Cells, Cultured; Disease Models, Animal; Down-Regulation; Heart Failure; Isoproterenol; Membrane Potentials; Myocardial Contraction; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propranolol; Rabbits; Receptors, Adrenergic, beta; Sarcoplasmic Reticulum; Sodium; Sodium-Calcium Exchanger; Up-Regulation; Ventricular Dysfunction, Left | 2001 |
Inhibition of adenosine deaminase attenuates endotoxin-induced release of cytokines in vivo in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Blood Pressure; Caffeine; Catecholamines; Cytokines; Endotoxemia; Endotoxins; Enzyme Inhibitors; Heart; Heart Rate; Male; Propranolol; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Renin; Xanthines | 2001 |
Mitogenic stimulation in isoproterenol treated cells of dictyostelium discoideum.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Caffeine; Cell Division; Central Nervous System Stimulants; Dictyostelium; DNA; Dose-Response Relationship, Drug; Isoproterenol; Leucine; Mitogens; Phagocytosis; Propranolol; Thymidine; Time Factors | 2002 |
Methylcellulose-immobilized reversed-phase precolumn for direct analysis of drugs in plasma by HPLC.
Topics: Animals; Atenolol; Caffeine; Chromatography, Gel; Chromatography, High Pressure Liquid; Humans; Ketoprofen; Male; Methylcellulose; Pharmaceutical Preparations; Propranolol; Proteins; Rats; Silicon Dioxide; Time Factors | 2001 |
Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans.
Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Caffeine; Drug Combinations; Epinephrine; Glucose Tolerance Test; Humans; Insulin Antagonists; Male; Propranolol | 2002 |
Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilation.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Caffeine; Calcium Channel Blockers; Coronary Circulation; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dogs; Enalaprilat; Hemodynamics; Phosphodiesterase Inhibitors; Propranolol; Purines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Vasodilation; Verapamil | 2002 |
Repeatability and reproducibility of high concentration data in reversed-phase liquid chromatography. I. Overloaded band profiles on Kromasil-C18.
Topics: Adsorption; Aniline Compounds; Benzene Derivatives; Caffeine; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Indicators and Reagents; Mathematics; Phenol; Propranolol; Reproducibility of Results; Theophylline | 2003 |
Repeatability and reproducibility of high-concentration data in reversed-phase liquid chromatography. III. Isotherm reproducibility on Kromasil C18.
Topics: Adsorption; Aniline Compounds; Benzene Derivatives; Caffeine; Chromatography, Liquid; Phenol; Propranolol; Reproducibility of Results; Theophylline; Thermodynamics | 2004 |
A chromatographic estimate of the degree of surface heterogeneity of reversed-phase liquid chromatography packing materials. II-Endcapped monomeric C18-bonded stationary phase.
Topics: Adsorption; Alkanes; Caffeine; Chromatography, Liquid; Naphthalenesulfonates; Phenol; Propranolol; Thermodynamics | 2006 |
A chromatographic estimate of the degree of heterogeneity of RPLC packing materials. 1. Non-endcapped polymeric C30-bonded stationary phase.
Topics: Adsorption; Alkanes; Caffeine; Chromatography, Liquid; Models, Chemical; Naphthalenesulfonates; Phenol; Propranolol; Silicon Dioxide | 2006 |
A chromatographic estimate of the degree of surface heterogeneity of RPLC packing materials. III. Endcapped amido-embedded reversed phase.
Topics: Adsorption; Alkanes; Amides; Caffeine; Chromatography, Liquid; Models, Chemical; Naphthalenesulfonates; Phenol; Propranolol | 2006 |
Modifying drug release and tablet properties of starch acetate tablets by dry powder agglomeration.
Topics: Acetylglucosamine; Caffeine; Drug Compounding; Excipients; Microscopy, Electron, Scanning; Povidone; Powders; Propranolol; Solubility; Starch; Surface Properties; Tablets; Tensile Strength | 2007 |
Alpha-methyl-5-HT, a 5-HT2 receptor agonist, stimulates beta2-adrenoceptors in guinea pig airway smooth muscle.
Topics: Adrenergic beta-Antagonists; Animals; Caffeine; Calcium; Guinea Pigs; In Vitro Techniques; Ketanserin; Male; Muscle, Smooth; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Propanolamines; Propranolol; Receptors, Adrenergic, beta-2; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Trachea | 2006 |
Novel generic UPLC/MS/MS method for high throughput analysis applied to permeability assessment in early Drug Discovery.
Topics: Ampicillin; Atenolol; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Griseofulvin; Permeability; Pharmaceutical Preparations; Propranolol; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Development of in-tube solid-phase microextraction coupled to pressure-assisted CEC and its application to the analysis of propranolol enantiomers in human urine.
Topics: Caffeine; Capillary Electrochromatography; Pressure; Propranolol; Solid Phase Microextraction; Theobromine; Theophylline | 2007 |
Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Barium Compounds; Caffeine; Calcium; Calcium Channels; Calcium Chloride; Chlorides; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Epinephrine; Furocoumarins; Glyburide; In Vitro Techniques; Mesenteric Arteries; Omentum; Potassium Chloride; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin; Tetraethylammonium; Vasodilation | 2007 |
Comparison of the performance of a few packing materials designed to minimize the thermodynamic band tailing of basic compounds in reversed-phase liquid chromatography.
Topics: Adsorption; Caffeine; Chromatography, Liquid; Hydrogen-Ion Concentration; Propranolol; Sodium Chloride; Thermodynamics | 2008 |
Caffeine poisoning and lactate rise: an overlooked toxic effect?
Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antidotes; Anxiety; Caffeine; Central Nervous System Stimulants; Charcoal; Female; Gastric Lavage; Humans; Hypokalemia; Lactic Acid; Midazolam; Ondansetron; Propranolol; Rare Diseases; Severity of Illness Index; Suicide, Attempted; Treatment Outcome | 2008 |
Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract.
Topics: Adipocytes; Adipose Tissue, White; Adrenergic beta-Antagonists; Animals; Body Composition; Body Weight; Caffeine; Cells, Cultured; Cirsium; Drug Synergism; Ion Channels; Lipolysis; Male; Mitochondrial Proteins; Phosphodiesterase Inhibitors; Phytotherapy; Plant Extracts; Propranolol; Rats; Rats, Wistar; Skin; Uncoupling Protein 1; Uncoupling Protein 3; Up-Regulation | 2009 |
Role of adrenergic receptors in the caffeine-induced increase in glucose uptake by the canine hindlimb.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Biological Transport; Blood Glucose; Caffeine; Dogs; Electric Stimulation; Hindlimb; Hyperglycemia; Male; Muscle Contraction; Muscle, Skeletal; Prazosin; Propranolol; Receptors, Adrenergic; Regional Blood Flow; Time Factors; Up-Regulation | 2009 |
Potential for biodegradation and sorption of acetaminophen, caffeine, propranolol and acebutolol in lab-scale aqueous environments.
Topics: Acebutolol; Acetaminophen; Adsorption; Biodegradation, Environmental; Caffeine; Cardiovascular Agents; Central Nervous System Stimulants; Clinical Laboratory Techniques; Environmental Restoration and Remediation; Propranolol; Sensory System Agents; Water Pollutants, Chemical | 2010 |
Β-blockade affects simulator scores.
Topics: Adrenergic beta-Antagonists; Adult; Caffeine; Cataract Extraction; Central Nervous System Stimulants; Clinical Competence; Computer Simulation; Female; Humans; Internship and Residency; Male; Microsurgery; Middle Aged; Optometry; Propranolol; Students, Medical; Task Performance and Analysis; User-Computer Interface; Young Adult | 2011 |
Fast investigations from biological matrices using CE--test of a blood-brain barrier model.
Topics: Acetaminophen; Adsorption; Animals; Blood-Brain Barrier; Caffeine; Carbamazepine; Cell Culture Techniques; Cell Line; Chromatography, Micellar Electrokinetic Capillary; Cimetidine; Humans; Indomethacin; Limit of Detection; Models, Biological; Propranolol; Rats; Reproducibility of Results; Tissue Distribution | 2012 |
Distribution and temporal evolution of pharmaceutically active compounds alongside sewage sludge treatment. Risk assessment of sludge application onto soils.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carbamazepine; Clofibric Acid; Environmental Pollutants; Environmental Pollution; Estradiol; Gemfibrozil; Propranolol; Risk Assessment; Sewage; Soil; Spain; Time Factors | 2012 |
The chick chorioallantoic membrane imaging method as a platform to evaluate vasoactivity and assess irritancy of compounds.
Topics: Animals; Blood Vessels; Caffeine; Chick Embryo; Chorioallantoic Membrane; Drug Evaluation, Preclinical; Glucagon; Glycerol; Homeostasis; Irritants; Nicotine; Propranolol; Solvents; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2012 |
The novel compound liguzinediol exerts positive inotropic effects in isolated rat heart via sarcoplasmic reticulum Ca2+ ATPase-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart; Male; Myocardial Contraction; Myocytes, Cardiac; Nimodipine; Ouabain; Prazosin; Propranolol; Pyrazines; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin | 2012 |
Continuous-flow liquid microjunction surface sampling probe connected on-line with high-performance liquid chromatography/mass spectrometry for spatially resolved analysis of small molecules and proteins.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cocaine; Coffea; Flow Injection Analysis; Propranolol; Proteins; Sheep; Spectrometry, Mass, Electrospray Ionization | 2013 |
Poly vinyl acetate and ammonio methacrylate copolymer as unconventional polymer blends increase the mechanical robustness of HPMC matrix tablets.
Topics: Caffeine; Carbamazepine; Chemistry, Pharmaceutical; Drug Compounding; Drug Liberation; Excipients; Hypromellose Derivatives; Permeability; Polymers; Polyvinyls; Propranolol; Solubility; Tablets | 2017 |
Remobilization Dynamics of Caffeine, Ciprofloxacin, and Propranolol following Evaporation-Induced Immobilization in Porous Media.
Topics: Adsorption; Caffeine; Ciprofloxacin; Porosity; Propranolol; Water Pollutants, Chemical; Water Purification | 2017 |
Mucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules.
Topics: Caffeine; Cell Line; Diffusion; Epithelium; Gastric Mucins; Humans; Mannitol; Mouth Mucosa; Mucus; Nicotine; Permeability; Propranolol; Small Molecule Libraries | 2017 |
Simultaneous determination of isoproterenol, acetaminophen, folic acid, propranolol and caffeine using a sensor platform based on carbon black, graphene oxide, copper nanoparticles and PEDOT:PSS.
Topics: Acetaminophen; Bridged Bicyclo Compounds, Heterocyclic; Caffeine; Copper; Folic Acid; Graphite; Isoproterenol; Metal Nanoparticles; Molecular Structure; Oxides; Particle Size; Polymers; Polystyrenes; Propranolol; Soot | 2018 |
Dangerous mistake: an accidental caffeine overdose.
Topics: Acidosis; Administration, Intravenous; Adult; Aftercare; Anti-Arrhythmia Agents; Caffeine; Dietary Supplements; Electrocardiography; Female; Humans; Hypokalemia; Propranolol; Psychomotor Agitation; Rare Diseases; Syncope; Tachycardia; Treatment Outcome | 2018 |
The role of freshwater copepods in the environmental risk assessment of caffeine and propranolol mixtures in the surface water bodies of Spain.
Topics: Animals; Caffeine; Copepoda; Fresh Water; Propranolol; Risk Assessment; Spain; Water Pollutants, Chemical | 2019 |
Adrenergic urticaria: a rare underdiagnosed subtype.
Topics: Adrenergic beta-Antagonists; Adult; Caffeine; Epinephrine; Female; Humans; Norepinephrine; Propranolol; Stress, Psychological; Treatment Outcome; Urticaria | 2020 |
Quantification of porogen effect on the drug release from single- and multi-layered ethylcellulose coated pellets containing single or combined drugs.
Topics: Caffeine; Carbamazepine; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Models, Theoretical; Porosity; Propranolol; Solubility; Water | 2020 |
A MULTIFACTORIAL APPROACH FOR IMPROVING THE SURGICAL PERFORMANCE OF NOVICE VITREORETINAL SURGEONS.
Topics: Adrenergic beta-Antagonists; Adult; Alcohol Drinking; Blood Alcohol Content; Caffeine; Central Nervous System Stimulants; Clinical Competence; Computer Simulation; Cross-Sectional Studies; Educational Measurement; Humans; Propranolol; Prospective Studies; Psychomotor Performance; Sleep Deprivation; Vitreoretinal Surgery | 2021 |