propranolol has been researched along with 4-hydroxypropranolol in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 48 (60.76) | 18.7374 |
| 1990's | 19 (24.05) | 18.2507 |
| 2000's | 7 (8.86) | 29.6817 |
| 2010's | 4 (5.06) | 24.3611 |
| 2020's | 1 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Baker, JK; Rauls, DO | 1 |
| Daniell, HB; Gaffney, TE; Knapp, DR; Oatis, JE; Walle, T | 1 |
| Knapp, DR; Oatis, JE; Russell, MP; Walle, T | 1 |
| Bartels, MJ; Bednarski, PJ; Horng, JS; Messick, K; Nelson, WL; Ruffolo, RR; Zhang, S | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Conradi, E; Morrison, J; Walle, K; Walle, T | 1 |
| Chiou, WL; Nation, RL; Peng, GW | 1 |
| Shwed, JA; Walle, T; Walle, UK | 1 |
| Ebihara, A; Fujimura, A; Ohashi, K; Tateishi, T | 1 |
| Fujita, S; Masubuchi, Y; Suzuki, K; Suzuki, T | 1 |
| Ishizu, H; Moriya, F | 1 |
| Miller, RB | 1 |
| Gillam, EM; Lennard, MS; Otton, SV; Tucker, GT; Woods, HF | 1 |
| Kashiwada, K; Ogata, H; Ohira, M; Someya, K; Takahashi, H; Warabioka, R | 1 |
| Imai, H; Tamai, G | 1 |
| Liedholm, H; Melander, A; Wåhlin-Boll, E | 1 |
| Derendorf, H; Lopez, LM; Schaefer, HG; Spahn, H | 1 |
| Christ, DD; Walle, T | 1 |
| Manners, CN; Payling, DW; Smith, DA | 1 |
| Fu, CW; Mason, WD | 1 |
| Biollaz, J; Koshakji, RP; Shaheen, O; Wilkinson, GR; Wood, AJ | 1 |
| Elkins, RP; Kelly, JF; Rosenberg, BJ | 1 |
| Abels, R; Huang, SM; Marinan, B; Marriott, TB; Weintraub, HS | 1 |
| Abdel-Hamid, ME | 1 |
| Green, VI; Mason, RP; Sood, SP | 1 |
| Koshakji, RP; Wood, AJ | 1 |
| Bottorff, MB; Lalonde, RL; Mirvis, DM; Pieper, JA; Straka, RJ | 2 |
| Crous, M; Smith, KA; Wood, S | 1 |
| Cvelbar, P; Francetić, I; Kopitar, Z; Lenardic, A; Vrhova, B; Zorz, M | 1 |
| Steiner, E; Tawara, K; von Bahr, C | 1 |
| Mullins, RE; Ray, K; Trawick, WG | 1 |
| Albani, F; Baldrati, A; Baruzzi, A; Cortelli, P; D'Alessandro, R; Lugaresi, E; Sacquegna, T | 1 |
| Ho Ngoc-Ta Trung, A; Sirois, G | 1 |
| Christ, DD; Walle, T; Walle, UK; Wilson, MJ | 1 |
| Fitzgerald, JD; O'Donnell, SR | 1 |
| Drummer, OH; Louis, WJ; McNeil, J; Pritchard, E | 1 |
| Charles, BG; Ravenscroft, PJ; Renshaw, PJ | 1 |
| Freestone, S; Jackson, PR; Lennard, MS; Ramsay, LE; Tucker, GT; Woods, HF | 2 |
| Bilezikian, JP; Gammon, DE; Rochester, CL; Shane, E | 1 |
| Norris, RM; Paxton, JW | 1 |
| Albani, F; Baldrati, A; Baruzzi, A; Cortelli, P; Perucca, E; Procaccianti, G; Riva, R | 1 |
| Hibbard, DM; Hunninghake, DB; Peters, JR | 1 |
| Walle, T; Wilson, MJ | 1 |
| Effeney, DJ; Lo, MW; Pond, SM; Riegelman, S; Silber, BM; Tozer, TN | 1 |
| Mehta, J; Mehta, P; Ostrowski, N | 1 |
| Faber, J; Friis, T; Jørgensen, PH; Kirkegaard, C; Lumholtz, IB; Siersbaek-Nielsen, K | 1 |
| Koshakji, RP; Raghuram, TC; Wilkinson, GR; Wood, AJ | 1 |
| Holford, NH; Riegelman, S; Silber, BM | 1 |
| Hammill, SC; Pritchett, EL; Shand, DG; Stargel, WW; Wagner, GS | 1 |
| Albani, F; Baruzzi, A; Riva, R | 1 |
| Lo, MW; Riegelman, S; Silber, B | 1 |
| Hermansson, J; Lind, M; von Bahr, C | 1 |
| Hermansson, J; Tawara, K; Von Bahr, C | 1 |
| Bogaert, MG; Rosseel, MT | 1 |
| Conradi, EC; Fagan, TC; Gaffney, TE; Oexmann, MJ; Walle, T; Walle, UK | 1 |
| Chou, D; Eckfeldt, JH; Holtzman, JL; Tsuru, M | 1 |
| Braeckman, P; Gyselinck, P; Remon, JP; Van Severen, R | 1 |
| Chadwick, IG; Ellis, SW; Haq, I; Jackson, PR; Lennard, MS; Ramsay, LE; Rowland, K; Tucker, GT; Yeo, WW | 1 |
| Herring, VL; Johnson, JA | 1 |
| Eller, TD; Walle, T; Walle, UK | 1 |
| Bichara, N; Blake, CL; Ching, MS; Ghabrial, H; Smallwood, RA; Tukey, RH | 1 |
| Muir, WW; Sams, RA; Schall, SF | 1 |
| Ghabrial, H; Morgan, DJ; Nand, RA; Smallwood, RA | 1 |
| Arai, T; Cho, AK; Horie, T; Ishikawa, T; Kumagai, Y; Masubuchi, Y; Narimatsu, S; Suzuki, T; Tsutsui, M; Watanabe, T | 1 |
| Benet, LZ; Chang, YP; Gee, WL; Lin, ET; Wu, ST | 1 |
| Barbhaiya, RH; Greene, DS; Kollia, GD; Marathe, PH | 1 |
| Asaoka, K; Horie, T; Hosokawa, M; Ishikawa, T; Kataoka, H; Kitada, M; Kobayashi, N; Masubuchi, Y; Miyano, J; Narimatsu, S; Ohmori, S; Yamamoto, S | 1 |
| Arai, T; Cho, AK; Horie, T; Hosokawa, M; Ishikawa, T; Kataoka, H; Masubuchi, Y; Narimatsu, S; Ueno, K; Yamamoto, S | 1 |
| Mak, IT; Weglicki, WB | 1 |
| Hanioka, N; Ishikawa, T; Miyano, J; Naito, S; Narimatsu, S; Nishimura, M; Ogura, K; Ueda, N; Watabe, T; Yamamoto, S | 1 |
| Gurule, S; Khuroo, A; Modhave, Y; Monif, T; Partani, P | 1 |
| Bonato, PS; Borges, KB; de Freitas, LA; Pupo, MT | 1 |
| Hanioka, N; Nagaoka, K; Narimatsu, S; Shimizudani, T; Yamano, S | 1 |
| Bonato, PS; Borges, KB; Pupo, MT | 1 |
| Edom, RW; Gallagher, J; Jian, W; Weng, N; Xu, Y | 1 |
| Brown, AK; Wong, CS | 1 |
| Bureik, M; Liu, S; Parr, MK; Wolber, G; Yang, F | 1 |
1 review(s) available for propranolol and 4-hydroxypropranolol
| Article | Year |
|---|---|
Pharmacokinetic studies: their role in determining therapeutic efficacy of agents designed to prevent sudden death.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Coronary Disease; Death, Sudden; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Myocardial Infarction; Piperidines; Propranolol | 1982 |
5 trial(s) available for propranolol and 4-hydroxypropranolol
| Article | Year |
|---|---|
The influence of diltiazem versus cimetidine on propranolol metabolism.
Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Diltiazem; Half-Life; Humans; Lactates; Male; Premedication; Propranolol | 1992 |
Etintidine-propranolol interaction study in humans.
Topics: Adolescent; Adult; Double-Blind Method; Drug Interactions; Half-Life; Histamine H2 Antagonists; Humans; Imidazoles; Male; Propranolol | 1987 |
Combined high-performance liquid chromatographic procedure for measuring 4-hydroxypropranolol and propranolol in plasma: pharmacokinetic measurements following conventional and slow-release propranolol administration.
Topics: Adult; Biological Availability; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Double-Blind Method; Humans; Propranolol | 1981 |
Inhibition of CYP2D6 activity by treatment with propranolol and the role of 4-hydroxy propranolol.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Male; Metoprolol; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Phenotype; Propranolol; Recombinant Proteins; Saccharomyces cerevisiae | 1994 |
A pharmacokinetic interaction study of avitriptan and propranolol.
Topics: Adrenergic beta-Antagonists; Adult; Analysis of Variance; Area Under Curve; Cross-Over Studies; Female; Humans; Indoles; Male; Propranolol; Serotonin Receptor Agonists; Sulfonamides; Tryptamines | 1998 |
73 other study(ies) available for propranolol and 4-hydroxypropranolol
| Article | Year |
|---|---|
Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogues.
Topics: Animals; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry, Physical; In Vitro Techniques; Lipids; Myocardial Contraction; Propranolol; Rabbits; Solubility; Structure-Activity Relationship | 1979 |
Synthesis of 4'-hydroxypropranolol sulfate, a major non-beta-blocking propranolol metabolite in man.
Topics: Adrenergic beta-Antagonists; Animals; Dogs; Dose-Response Relationship, Drug; Propranolol | 1985 |
Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers.
Topics: Adrenergic beta-Antagonists; Animals; Dogs; Female; Hydroxylation; Male; Propranolol; Structure-Activity Relationship; Vasodilator Agents | 1981 |
The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite.
Topics: Animals; Female; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Liver; Magnetic Resonance Spectroscopy; Male; Myocardium; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Uterus | 1984 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
Simultaneous determination of propranolol and 4-hydroxypropranolol in plasma by mass fragmentography.
Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Methods; Propranolol | 1975 |
High-pressure liquid chromatographic method for the simultaneous quantitative analysis of propranolol and 4-hydroxypropranolol in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Propranolol | 1978 |
Hep G2 cell line as a human model for sulphate conjugation of drugs.
Topics: Arylsulfotransferase; Carcinoma, Hepatocellular; Dopamine; Humans; Liver; Liver Neoplasms; Nitrophenols; Propranolol; Sulfates; Temperature; Terbutaline; Tumor Cells, Cultured | 1992 |
A possible mechanism of the impairment of hepatic microsomal monooxygenase activities after multiple administration of propranolol in rats.
Topics: Animals; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygenases; Propranolol; Rats; Rats, Inbred Strains | 1992 |
Interactive effect of ethanol administration on blood propranolol levels in rats.
Topics: Administration, Oral; Animals; Drug Interactions; Ethanol; Intestinal Absorption; Male; Microsomes, Liver; Propranolol; Rats; Rats, Inbred Strains | 1991 |
High-performance liquid chromatographic assay for the derivatized enantiomers of propranolol and 4-hydroxypropranolol in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Isothiocyanates; Propranolol; Reproducibility of Results; Spectrometry, Fluorescence; Stereoisomerism; Thiocyanates | 1991 |
Propranolol oxidation by human liver microsomes--the use of cumene hydroperoxide to probe isoenzyme specificity and regio- and stereoselectivity.
Topics: Benzene Derivatives; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; Oxidation-Reduction; Phenotype; Propranolol; Stereoisomerism; Substrate Specificity | 1990 |
Decreased absorption as a possible cause for the lower bioavailability of a sustained-release propranolol.
Topics: Adult; Biological Availability; Capsules; Delayed-Action Preparations; Female; Glucuronates; Half-Life; Humans; Intestinal Absorption; Male; Oxidation-Reduction; Propranolol; Solubility; Sulfates | 1990 |
Determination of propranolol and 4-hydroxypropranolol in tissue homogenates by direct injection and column switching HPLC.
Topics: Animals; Chromatography, High Pressure Liquid; Guinea Pigs; Propranolol | 1990 |
Mechanisms and variations in the food effect on propranolol bioavailability.
Topics: Adult; Biological Availability; Dietary Carbohydrates; Dietary Proteins; Female; Food; Humans; Lactates; Middle Aged; Propranolol; Propylene Glycol; Propylene Glycols | 1990 |
Simultaneous determination of propranolol and 4-hydroxypropranolol enantiomers after chiral derivatization using reversed-phase high-performance liquid chromatography.
Topics: Animals; Arylsulfatases; Chromatography, High Pressure Liquid; Cyanates; Dogs; Ethylamines; Glucuronates; Glucuronidase; Humans; Isocyanates; Male; Propranolol; Stereoisomerism; Sulfates | 1990 |
Stereoselective sulfation of R,S-4'-hydroxypropranolol by canine hepatic cytosol and partially purified phenolsulfotransferases.
Topics: Animals; Arylsulfotransferase; Cytosol; Dogs; Dopamine; Female; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Liver; Male; Pentachlorophenol; Propranolol; Stereoisomerism; Sulfates | 1989 |
Lipophilicity of zwitterionic sulphate conjugates of tiaramide, propranolol and 4'-hydroxypropranolol.
Topics: Benzothiazoles; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Piperazines; Propranolol; Sulfates | 1989 |
Determination of propranolol and 4-hydroxypropranolol in human plasma by high-performance liquid chromatography.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Propranolol; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1989 |
Influence of debrisoquin phenotype on the inducibility of propranolol metabolism.
Topics: Adult; Debrisoquin; Enzyme Induction; Glucuronates; Humans; Isoquinolines; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Phenotype; Propranolol | 1989 |
A radioreceptor assay in which iodocyanopindolol is used to determine propranolol and its active metabolites in unextracted serum or plasma.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Chromatography, High Pressure Liquid; Erythrocyte Membrane; Humans; Iodocyanopindolol; Pindolol; Plasma; Propranolol; Radioligand Assay; Turkeys | 1986 |
High-performance liquid chromatographic determination of propranolol and 4-hydroxypropranolol in serum.
Topics: Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Predictive Value of Tests; Propranolol | 1988 |
Routine methods in toxicology and therapeutic drug monitoring by high-performance liquid chromatography. IV. A rapid microscale method for determination of propranolol and 4-hydroxypropranolol in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Propranolol; Spectrometry, Fluorescence | 1988 |
Improved high-performance liquid chromatographic method for the simultaneous determination of propranolol and 4-hydroxypropranolol in plasma with fluorescence detection.
Topics: Antioxidants; Chromatography, High Pressure Liquid; Drug Stability; Humans; Indicators and Reagents; Methanol; Propranolol; Spectrometry, Fluorescence | 1987 |
Propranolol pharmacodynamic modeling using unbound and total concentrations in healthy volunteers.
Topics: Adult; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Evaluation; Electrocardiography; Half-Life; Heart Rate; Humans; Male; Models, Biological; Physical Exertion; Propranolol; Random Allocation | 1987 |
Rapid high-performance liquid chromatographic method for the determination of propranolol in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Propranolol | 1987 |
Propranolol pharmacokinetics and pharmacodynamics after single doses and at steady-state.
Topics: Administration, Oral; Adult; Delayed-Action Preparations; Heart; Heart Rate; Humans; Male; Physical Exertion; Propranolol | 1987 |
Dose-dependent bioavailability of propranolol.
Topics: Adult; Biological Availability; Dose-Response Relationship, Drug; Humans; Male; Propranolol | 1986 |
The effect of propranolol on exercise induced tachycardia is determined by plasma concentration and the density of adrenergic receptors on leukocytes.
Topics: Adult; Heart Rate; Humans; Leukocytes; Male; Neutrophils; Physical Exertion; Pindolol; Propranolol; Receptors, Adrenergic | 1987 |
Assay of total and free propranolol in plasma by liquid chromatography with fluorometric detection.
Topics: Binding, Competitive; Blood Proteins; Chromatography, High Pressure Liquid; Humans; Pharmaceutical Preparations; Propranolol; Protein Binding; Spectrometry, Fluorescence; Ultrafiltration | 1985 |
Propranolol plasma levels and relief of migraine. Relationship between plasma propranolol and 4-hydroxypropranolol concentrations and clinical effects.
Topics: Adult; Female; Humans; Male; Middle Aged; Migraine Disorders; Propranolol | 1985 |
Competitive binding of quinidine, propranolol, and 4-OH-propranolol to human plasma very low-density (VLDL) and low-density (LDL) lipoproteins.
Topics: Binding, Competitive; Humans; Lipoproteins, LDL; Lipoproteins, VLDL; Propranolol; Protein Binding; Quinidine | 1985 |
Separation of the enantiomers of intact sulfate conjugates of adrenergic drugs by high-performance liquid chromatography after chiral derivatization.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Hypertension; Propranolol; Spectrophotometry, Ultraviolet; Stereoisomerism; Sulfates; Sympathomimetics | 1985 |
Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Bronchi; Carbon Isotopes; Catecholamines; Cats; Dogs; Drug Synergism; Female; Guinea Pigs; Heart Rate; Isoproterenol; Male; Propranolol; Rats; Sympathomimetics | 1971 |
Comparative pharmacokinetics of propranolol and 4-hydroxypropranolol using conventional and long-acting propranolol.
Topics: Adolescent; Adult; Delayed-Action Preparations; Humans; Intestinal Absorption; Kinetics; Male; Propranolol | 1982 |
The oral clearance and beta-adrenoceptor antagonist activity of propranolol after single dose are not related to debrisoquine oxidation phenotype.
Topics: Adrenergic beta-Antagonists; Debrisoquin; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Oxidation-Reduction; Phenotype; Propranolol | 1984 |
A radioreceptor assay for propranolol and 4-hydroxypropranolol.
Topics: Animals; Binding Sites; Blood Proteins; Blood Specimen Collection; Drug Stability; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Propranolol; Protein Binding; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1980 |
Propranolol disposition after acute myocardial infarction.
Topics: Administration, Oral; Adult; Aged; Chromatography, High Pressure Liquid; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Myocardial Infarction; Orosomucoid; Pain; Propranolol; Protein Binding; Thorax | 1984 |
Plasma concentrations of propranolol and 4-hydroxy-propranolol at steady-state in neurological patients: intersubject and intrasubject correlations with dose.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Humans; Individuality; Male; Middle Aged; Migraine Disorders; Propranolol; Tremor | 1984 |
Effects of cholestyramine and colestipol on the plasma concentrations of propranolol.
Topics: Adult; Biotransformation; Cholestyramine Resin; Colestipol; Drug Interactions; Humans; Kinetics; Male; Middle Aged; Polyamines; Propranolol | 1984 |
Silica gel high-performance liquid chromatography for the simultaneous determination of propranolol and 4-hydroxypropranolol enantiomers after chiral derivatization.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cyanates; Glucuronates; Humans; Isocyanates; Mass Spectrometry; Propranolol; Stereoisomerism; Sulfates | 1984 |
Nonlinear formation of propranolol metabolites in dogs after portacaval transpositions.
Topics: Animals; Dogs; Kinetics; Lactates; Liver; Male; Mathematics; Metabolic Clearance Rate; Portacaval Shunt, Surgical; Propranolol; Time Factors | 1984 |
Influence of propranolol and 4-hydroxypropranolol on platelet aggregation and thromboxane A2 generation.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Cell Membrane; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Platelet Aggregation; Propranolol; Thromboxane A2; Thromboxanes | 1983 |
The effect of D,L-4-hydroxypropranolol on the thyroxine to 3,5,3'-triiodothyronine conversion in rat renal and liver microsomes.
Topics: Animals; Isoproterenol; Kidney; Male; Microsomes; Microsomes, Liver; Propranolol; Rats; Rats, Inbred Strains; Thyroxine; Triiodothyronine | 1984 |
Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade.
Topics: Adult; Chromatography, High Pressure Liquid; Debrisoquin; Heart Rate; Humans; Hydroxylation; Male; Phenotype; Physical Exertion; Polymorphism, Genetic; Propranolol | 1984 |
The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol.
Topics: Adult; Debrisoquin; Humans; Isoquinolines; Kinetics; Male; Oxidation-Reduction; Phenotype; Propranolol | 1984 |
Dose-dependent elimination of propranolol and its major metabolites in humans.
Topics: Adult; Biotransformation; Glucuronates; Half-Life; Humans; Kinetics; Propranolol | 1983 |
Simple and rapid determination of propranolol and its active metabolite, 4-hydroxypropranolol, in human plasma by liquid chromatography with fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Propranolol; Spectrometry, Fluorescence | 1982 |
An automated HPLC method for the assay of propranolol and its basic metabolites in plasma and urine.
Topics: Chromatography, High Pressure Liquid; Humans; Propranolol | 1982 |
Oxidation of (R)- and (S)-propranolol in human and dog liver microsomes. Species differences in stereoselectivity.
Topics: Adult; Animals; Dogs; Glucuronates; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Middle Aged; Oxidation-Reduction; Propranolol; Species Specificity; Stereoisomerism | 1982 |
Plasma levels of (+) and (-)-propranolol and 4-hydroxypropranolol after administration of racemic (+/-)-propranolol in man.
Topics: Administration, Oral; Adult; Female; Humans; Injections, Intravenous; Male; Propranolol; Stereoisomerism | 1982 |
High-performance liquid chromatographic determination of propranolol and 4-hydroxypropranolol in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Propranolol | 1981 |
Food-induced increase in propranolol bioavailability--relationship to protein and effects on metabolites.
Topics: Adult; Biological Availability; Dietary Proteins; Eating; Half-Life; Humans; Male; Propranolol; Tissue Distribution | 1981 |
Interference by the 4-hydroxylated metabolite of propranolol with determination of metanephrines by the Pisano method.
Topics: Chromatography, Ion Exchange; Epinephrine; Humans; Metanephrine; Propranolol; Spectrophotometry, Ultraviolet | 1980 |
An improved extraction procedure for the liquid chromatographic determination of propranolol and 4-hydroxypropranolol in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Propranolol | 1980 |
Direct high-performance liquid chromatographic determination in urine of the enantiomers of propranolol and its major basic metabolite 4-hydroxypropranolol.
Topics: Chromatography, High Pressure Liquid; Glucuronates; Humans; Male; Oxidation-Reduction; Propranolol; Spectrometry, Fluorescence; Stereoisomerism | 1993 |
Immunoaffinity isolation of the sulfate conjugate of 4'-hydroxypropranolol from plasma.
Topics: Adult; Antibody Specificity; Chromatography, Affinity; Female; Humans; Male; Propranolol; Radioimmunoassay; Sulfates | 1993 |
Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2.
Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Humans; Hydroxylation; Microsomes, Liver; Molecular Conformation; Propranolol | 1996 |
Haemodynamic, electrocardiographic, electrophysiologic and pharmacokinetic activity of 4'-hydroxypropranolol in dogs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiac Output; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Half-Life; Heart Rate; Infusions, Intravenous; Male; Propranolol | 1996 |
(S)-4'-hydroxypropranolol causes product inhibition and dose-dependent bioavailability of propranolol enantiomers in the isolated perfused rat liver and in rat liver microsomes.
Topics: Animals; Biological Availability; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Microsomes, Liver; Propranolol; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1996 |
Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins of the rat.
Topics: Adrenergic beta-Antagonists; Animals; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Male; Microsomes, Liver; Naphthalenes; Phenobarbital; Propranolol; Protein Binding; Rabbits; Rats; Superoxides | 1997 |
Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Isothiocyanates; Propranolol; Reproducibility of Results; Stereoisomerism | 1997 |
High-performance liquid chromatographic analysis of the sulfation of 4-hydroxypropranolol enantiomers by monkey liver cytosol.
Topics: Adult; Aged; Animals; Arylsulfotransferase; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Cytosol; Dogs; Humans; Kinetics; Liver; Liver Neoplasms; Macaca; Male; Middle Aged; Propranolol; Rabbits; Rats; Rats, Wistar; Species Specificity; Stereoisomerism; Sulfates; Tumor Cells, Cultured | 2001 |
Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Propanolamines; Propranolol; Rats; Rats, Wistar; Substrate Specificity | 2001 |
Potent antioxidant properties of 4-hydroxyl-propranolol.
Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Drug Interactions; Endothelial Cells; Glutathione; Humans; Hydroxyl Radical; Lipoproteins, LDL; Male; Molsidomine; Oxidation-Reduction; Propranolol; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2004 |
Involvement of SULT1A3 in elevated sulfation of 4-hydroxypropranolol in Hep G2 cells pretreated with beta-naphthoflavone.
Topics: Arylsulfotransferase; beta-Naphthoflavone; Cell Line; Dose-Response Relationship, Drug; Humans; Isoenzymes; Propranolol; Sulfates; Sulfotransferases | 2005 |
Simultaneous determination of propranolol and 4-hydroxy propranolol in human plasma by solid phase extraction and liquid chromatography/electrospray tandem mass spectrometry.
Topics: Administration, Oral; Calibration; Chromatography, Liquid; Dose-Response Relationship, Drug; Humans; Hydrolysis; Ions; Propranolol; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temperature; Time Factors | 2009 |
Box-Behnken design for the optimization of an enantioselective method for the simultaneous analysis of propranolol and 4-hydroxypropranolol by CE.
Topics: beta-Cyclodextrins; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Propranolol; Regression Analysis; Stereoisomerism | 2009 |
Comparative study of the oxidation of propranolol enantiomers in hepatic and small intestinal microsomes from cynomolgus and marmoset monkeys.
Topics: Animals; Antibodies; Callithrix; Cytochrome P-450 Enzyme System; Humans; Intestine, Small; Kinetics; Liver; Macaca fascicularis; Microsomes; Oxidation-Reduction; Propranolol; Stereoisomerism | 2010 |
Enantioselective analysis of propranolol and 4-hydroxypropranolol by CE with application to biotransformation studies employing endophytic fungi.
Topics: Aspergillus fumigatus; Asteraceae; Biotransformation; Chaetomium; Electrophoresis, Capillary; Limit of Detection; Penicillium; Phyllachorales; Propranolol; Stereoisomerism | 2009 |
Potential bias and mitigations when using stable isotope labeled parent drug as internal standard for LC-MS/MS quantitation of metabolites.
Topics: Animals; Area Under Curve; Chromatography, Liquid; Clinical Trials as Topic; Humans; Isotope Labeling; Models, Chemical; Pharmaceutical Preparations; Propranolol; Rats; Reference Standards; Regression Analysis; Tandem Mass Spectrometry | 2010 |
Simultaneous quantification of propranolol and sulfamethoxazole and major human metabolite conjugates 4-hydroxy-propranolol sulfate and sulfamethoxazole-β-glucuronide in municipal wastewater-A framework for multiple classes of drugs and conjugates.
Topics: Canada; Chemistry Techniques, Analytical; Glucuronides; Humans; Propranolol; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Sulfamethoxazole; Sulfates; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical; Water Purification | 2016 |
Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families.
Topics: Glucuronides; Glucuronosyltransferase; Humans; Microsomes, Liver; Molecular Docking Simulation; Propranolol; UDP-Glucuronosyltransferase 1A9 | 2022 |