Page last updated: 2024-08-16

propofol and flumazenil

propofol has been researched along with flumazenil in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19902 (3.33)18.7374
1990's20 (33.33)18.2507
2000's14 (23.33)29.6817
2010's16 (26.67)24.3611
2020's8 (13.33)2.80

Authors

AuthorsStudies
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chollet-Rivier, M; Ravussin, P1
Ilkiw, JE1
Mori, K; Murayama, T; Ogawa, T; Shindo, K; Shingu, K; Tamai, S; Tomoda, K1
Hales, TG; Lambert, JJ1
Spiess, BD1
Dundas, CR; Norton, AC1
Harvey, PB; Kestin, IG; Nixon, C1
Freys, G; Jochum, D; Otteni, JC; Ravanello, J; Schaal, JC; Steib, A1
Beller, JP; Curzola, U; Freys, G; Jochum, D; Otteni, JC; Ravanello, J; Steib, A1
Forrest, P; Galletly, DC1
Chao, CC; Fan, SZ; Lin, SM; Liu, CC; Yu, HY1
D'Honneur, G; Duvaldestin, P; el Sayed, A; Lambert, Y; Rimaniol, JM1
Ghouri, AF; Ruiz, MA; White, PF1
Favre, JB; Moeschler, O; Ravussin, P1
Hara, M; Ikemoto, Y; Kai, Y1
Fassoulaki, A; Papilas, K; Sarantopoulos, C1
Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF1
Rodrigo, MR1
Hesselbjerg, L; Koscielniak-Nielsen, ZJ; Stens-Pedersen, HL1
Murata, Y1
Larson, JS; Lunn, JJ1
Kamei, J; Ohsawa, M1
Adachi, Y; Higuchi, H; Satoh, T; Uchihashi, Y; Watanabe, K1
Adachi, YU; Higuchi, H; Satoh, T; Watanabe, K2
Bluhm, B; Mendelson, WB; Tung, A1
Masuzawa, M; Miyamoto, E; Murayama, T; Nagata, A; Nakao, S; Shingu, K1
Bragulat, E; Coll-Vinent, B; Espinosa, G; Fernández, C; Millá, J; Miró, O; Sala, X; Sánchez, M1
Aalto, S; Hietala, J; Hinkka, S; Kaisti, KK; Korpi, ER; Metsähonkala, L; Någren, K; Oikonen, V; Salmi, E; Scheinin, H1
Cappell, MS1
Betts, BA; Gill, N; Griffith, TN; Hall, AC; Humbert, DJ; Jenkins, A; Kelly, EW; Kotey, FO; Rowan, KC; Veneskey, KC; Watt, EE1
Adachi, Y; Doi, M; Obata, Y; Sato, S; Suzuki, K1
Gerónimo Pardo, M; Mateo Cerdán, CM; Moreno Salcedo, JM1
Kanmura, Y; Moriyama, T; Tsuneyoshi, I1
Oppitz, F1
Baker, B; Raphael, D; Rinehart, JB1
Ichinohe, T; Matsuura, N; Tomita, S1
Kawamata, M; Kawamata, T; Koike, Y; Yamamoto, K1
Diedrich, A; Dietrich, CG; Drouven, FM; Kottmann, T1
Dong, Y; Shao, H; Xia, W; Xie, Z; Yu, B; Zhang, Y1
Absalom, NL; Chebib, M; Chua, HC; Hanrahan, JR; Viswas, R1
Absalom, NL; Chebib, M; Christensen, ET; Chua, HC; Hartiadi, LY; Hoestgaard-Jensen, K; Jensen, AA; Ramzan, I1
Vicari, JJ1
Baik, HJ; Moon, S1
Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y1
Adachi, YU; Higashi, M; Matsuda, N; Okuda, M; Sato, AB; Satomoto, M; Taharabaru, S; Tamura, T1
Doi, M; Katoh, T; Kobayashi, M; Kurita, T; Mimuro, S; Nakajima, Y; Sato, T1
Cho, HY; Kim, WH; Kim, YJ; Lee, HB; Lee, HJ; Seo, JH1
Huang, J; Liu, M; Luo, W; Miao, C; Sun, M; Wan, J; Xia, L; Xiong, W; Xu, P; Zhang, J; Zhang, X; Zhang, Z; Zhong, J1
Shimizu, T; Takasusuki, T; Yamaguchi, S1
Choi, EA; Chung, YJ; Kwon, EJ; Lee, JH; Min, JJ; Oh, EJ; On, YK1
Haraki, T; Horikawa, YT; Kamiya, S; Kido, K; Kondo, T; Nakamura, R; Narasaki, S; Oshita, K; Saeki, N; Toyota, Y; Tsutsumi, YM1

Reviews

5 review(s) available for propofol and flumazenil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Other potentially useful new injectable anesthetic agents.
    The Veterinary clinics of North America. Small animal practice, 1992, Volume: 22, Issue:2

    Topics: Anesthesia; Anesthetics; Animals; Cats; Dogs; Flumazenil; Midazolam; Propofol

1992
Comparing drugs for short-term sedation.
    Contemporary internal medicine, 1994, Volume: 6, Issue:12

    Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam; Pain; Propofol

1994
Sedation and analgesia for gastrointestinal endoscopy during pregnancy.
    Gastrointestinal endoscopy clinics of North America, 2006, Volume: 16, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Diazepam; Endoscopy, Gastrointestinal; Female; Fentanyl; Fetus; Flumazenil; Humans; Hypnotics and Sedatives; Ketamine; Lidocaine; Meperidine; Naloxone; Pregnancy; Propofol; Risk Assessment; Triage

2006
Sedation in the Ambulatory Endoscopy Center: Optimizing Safety, Expectations and Throughput.
    Gastrointestinal endoscopy clinics of North America, 2016, Volume: 26, Issue:3

    Topics: Ambulatory Care Facilities; Analgesics, Opioid; Antidotes; Benzodiazepines; Conscious Sedation; Deep Sedation; Efficiency; Endoscopy, Gastrointestinal; Flumazenil; Humans; Hypnotics and Sedatives; Monitoring, Intraoperative; Naloxone; Narcotic Antagonists; Patient Safety; Propofol

2016

Trials

18 trial(s) available for propofol and flumazenil

ArticleYear
Midazolam-flumazenil vs. propofol in ambulatory ENT endoscopic procedures.
    European journal of anaesthesiology, 1992, Volume: 9, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anesthesia Recovery Period; Anesthesia, Intravenous; Awareness; Blood Pressure; Cardiovascular Diseases; Endoscopy; Flumazenil; Heart Rate; Humans; Midazolam; Middle Aged; Otorhinolaryngologic Diseases; Propofol; Risk Factors; Safety; Time Factors

1992
Induction agents for day-case anaesthesia. A double-blind comparison of propofol and midazolam antagonised by flumazenil.
    Anaesthesia, 1990, Volume: 45, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Double-Blind Method; Flumazenil; Humans; Male; Midazolam; Propofol; Psychomotor Performance; Randomized Controlled Trials as Topic

1990
Psychomotor recovery after three methods of sedation during spinal anaesthesia.
    British journal of anaesthesia, 1990, Volume: 64, Issue:6

    Topics: Aged; Anesthesia Recovery Period; Anesthesia, Spinal; Double-Blind Method; Flicker Fusion; Flumazenil; Humans; Male; Memory, Short-Term; Midazolam; Preanesthetic Medication; Propofol; Prostatectomy; Psychomotor Performance; Randomized Controlled Trials as Topic

1990
Recovery from total intravenous anaesthesia. Propofol versus midazolam-flumazenil.
    Acta anaesthesiologica Scandinavica, 1990, Volume: 34, Issue:8

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Arousal; Blood Pressure; Eyelashes; Flumazenil; Humans; Memory; Midazolam; Middle Aged; Motor Skills; Propofol; Reflex; Time Factors

1990
Comparison of propofol and antagonised midazolam anaesthesia for day-case surgery.
    Anaesthesia and intensive care, 1987, Volume: 15, Issue:4

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, General; Anesthesia, Intravenous; Anesthetics; Arousal; Clinical Trials as Topic; Cystoscopy; Double-Blind Method; Female; Flumazenil; Humans; Isoflurane; Male; Midazolam; Middle Aged; Nitrous Oxide; Phenols; Propofol; Psychomotor Performance; Random Allocation

1987
Lack of effect of flumazenil on the reversal of propofol anaesthesia.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:3

    Topics: Adult; Anesthesia; Double-Blind Method; Drug Interactions; Female; Flumazenil; Humans; Propofol

1995
Midazolam/propofol but not propofol alone reversibly depress the swallowing reflex.
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:3

    Topics: Ambulatory Care; Anesthesia, Intravenous; Awareness; Colonoscopy; Deglutition; Depression, Chemical; Double-Blind Method; Drug Combinations; Electromyography; Flumazenil; Humans; Hyoid Bone; Midazolam; Placebos; Propofol; Reaction Time; Reflex

1994
Effect of flumazenil on recovery after midazolam and propofol sedation.
    Anesthesiology, 1994, Volume: 81, Issue:2

    Topics: Adult; Analysis of Variance; Anesthesia Recovery Period; Cognition; Conscious Sedation; Female; Flumazenil; Humans; Midazolam; Middle Aged; Monitoring, Intraoperative; Propofol; Psychomotor Performance

1994
Flumazenil reduces the duration of thiopentone but not of propofol anaesthesia in humans.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:1

    Topics: Anesthesia, Intravenous; Dilatation and Curettage; Double-Blind Method; Female; Flumazenil; Humans; Middle Aged; Movement; Placebos; Propofol; Thiopental; Time Factors

1993
Midazolam-flumazenil versus propofol anaesthesia for scoliosis surgery with wake-up tests.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Antidotes; Arousal; Child; Drug Costs; Evoked Potentials, Somatosensory; Female; Flumazenil; Humans; Intraoperative Care; Intubation, Intratracheal; Male; Memory; Midazolam; Monitoring, Intraoperative; Naloxone; Narcotic Antagonists; Pain; Postoperative Care; Propofol; Prospective Studies; Psychomotor Performance; Scoliosis; Spinal Cord; Wakefulness

1998
A small dose of midazolam decreases the time to achieve hypnosis without delaying emergence during short-term propofol anesthesia.
    Journal of clinical anesthesia, 2001, Volume: 13, Issue:4

    Topics: Adjuvants, Anesthesia; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Double-Blind Method; Female; Flumazenil; GABA Modulators; Hemodynamics; Humans; Male; Midazolam; Middle Aged; Propofol; Prospective Studies

2001
Sedation for cardioversion in the emergency department: analysis of effectiveness in four protocols.
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia Recovery Period; Clinical Protocols; Conscious Sedation; Drug Therapy, Combination; Electric Countershock; Emergency Medical Services; Etomidate; Female; Flumazenil; GABA Modulators; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Myoclonus; Outcome and Process Assessment, Health Care; Propofol; Prospective Studies; Treatment Outcome

2003
The combined effects of midazolam and propofol sedation on muscle power.
    Anaesthesia, 2013, Volume: 68, Issue:5

    Topics: Adult; Bite Force; Conscious Sedation; Consciousness Monitors; Cross-Over Studies; Flumazenil; Hand Strength; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Midazolam; Muscle Strength; Muscle Strength Dynamometer; Muscle, Skeletal; Neuropsychological Tests; Propofol; Sample Size; Stroop Test

2013
Comparison of the recovery profile of remimazolam with flumazenil and propofol anesthesia for open thyroidectomy.
    BMC anesthesiology, 2023, 05-02, Volume: 23, Issue:1

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Flumazenil; Humans; Postoperative Nausea and Vomiting; Propofol; Prospective Studies; Thyroidectomy

2023
Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial.
    BMC anesthesiology, 2023, 05-26, Volume: 23, Issue:1

    Topics: Ambulatory Surgical Procedures; Flumazenil; Humans; Hypotension; Pain; Propofol; Prospective Studies

2023
Remimazolam Compared to Propofol for Total Intravenous Anesthesia with Remifentanil on the Recovery of Psychomotor Function: A Randomized Controlled Trial.
    Advances in therapy, 2023, Volume: 40, Issue:10

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Flumazenil; Humans; Piperidines; Propofol; Remifentanil

2023
Comparison of propofol vs. remimazolam on emergence profiles after general anesthesia: A randomized clinical trial.
    Journal of clinical anesthesia, 2023, Volume: 90

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Benzodiazepines; Flumazenil; Humans; Propofol; Prospective Studies

2023
Remimazolam-based anesthesia with flumazenil allows faster emergence than propofol-based anesthesia in older patients undergoing spinal surgery: A randomized controlled trial.
    Medicine, 2023, Nov-17, Volume: 102, Issue:46

    Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Benzodiazepines; Flumazenil; Humans; Propofol; Prospective Studies; Single-Blind Method

2023

Other Studies

37 other study(ies) available for propofol and flumazenil

ArticleYear
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Flumazenil does not antagonize halothane, thiamylal or propofol anaesthesia in rats.
    British journal of anaesthesia, 1992, Volume: 69, Issue:1

    Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Behavior, Animal; Diazepam; Drug Interactions; Electroencephalography; Flumazenil; Halothane; Male; Propofol; Rats; Rats, Inbred Strains; Sleep; Thiamylal

1992
The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones.
    British journal of pharmacology, 1991, Volume: 104, Issue:3

    Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; Cerebral Cortex; Chromaffin System; Electric Stimulation; Female; Flumazenil; GABA-A Receptor Antagonists; Ion Channel Gating; Mice; Neural Conduction; Neurons; Pentobarbital; Pregnancy; Propofol; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glycine; Receptors, Neurotransmitter

1991
Two new pharmacological agents for the 1990s: flumazenil and propofol.
    Journal of post anesthesia nursing, 1990, Volume: 5, Issue:3

    Topics: Adjuvants, Anesthesia; Flumazenil; Humans; Perioperative Nursing; Propofol; Recovery Room

1990
[Comparative study of resuscitation from intravenous anesthesia with the exclusive use of propofol or midazolam and flumazenil].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl

    Topics: Adult; Anesthesia, Intravenous; Drug Combinations; Flumazenil; Humans; Male; Midazolam; Postoperative Period; Propofol

1989
[Indications for total intravenous anesthesia (TIVA) in neuroanesthesia].
    Minerva anestesiologica, 1993, Volume: 59, Issue:12

    Topics: Anesthesia, Intravenous; Brain; Flumazenil; Humans; Isoflurane; Nitric Oxide; Propofol

1993
Propofol activates GABAA receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat.
    Anesthesiology, 1993, Volume: 79, Issue:4

    Topics: Animals; Central Nervous System; Chloride Channels; Chlorides; Diazepam; Flumazenil; Hippocampus; Kinetics; Membrane Potentials; Neurons; Propofol; Pyramidal Tracts; Rats; Rats, Wistar; Receptors, GABA

1993
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
    Nature, 1997, Feb-27, Volume: 385, Issue:6619

    Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection

1997
Use of inhalational and intravenous sedation in dentistry.
    International dental journal, 1997, Volume: 47, Issue:1

    Topics: Accidents; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Anxiety Agents; Antidotes; Cause of Death; Computers; Conscious Sedation; Dental Care; Diazepam; Drug Overdose; Emergencies; Flumazenil; GABA Modulators; Humans; Hypnotics and Sedatives; Iatrogenic Disease; Infusion Pumps; Isoflurane; Midazolam; Nitrous Oxide; Oxygen; Practice Guidelines as Topic; Propofol; United Kingdom

1997
[Effects of anesthetics on somatosensory evoked potentials by median nerve stimulation in human--analyses after single administration in volunteers].
    Masui. The Japanese journal of anesthesiology, 1998, Volume: 47, Issue:8

    Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Electric Stimulation; Evoked Potentials, Somatosensory; Flumazenil; Humans; Male; Median Nerve; Midazolam; Naloxone; Nitrous Oxide; Propofol; Reaction Time; Thiopental

1998
Modification of the effect of diazepam on the propofol-induced loss of the righting reflex in mice by diabetes.
    Brain research, 1999, Jul-03, Volume: 833, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Diabetes Mellitus, Experimental; Diazepam; Flumazenil; GABA Modulators; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Posture; Propofol; Receptors, GABA-A; Reflex

1999
[Preliminary report: the effect of flumazenil on the hypnotic dose of propofol in ddY mice].
    Masui. The Japanese journal of anesthesiology, 2001, Volume: 50, Issue:2

    Topics: Acetic Acid; Anesthetics, Intravenous; Animals; Buffers; Drug Synergism; Flumazenil; GABA-A Receptor Antagonists; Hydrogen-Ion Concentration; Hypnosis, Anesthetic; Male; Mice; Propofol

2001
Sleep inducing effects of propofol microinjection into the medial preoptic area are blocked by flumazenil.
    Brain research, 2001, Jul-27, Volume: 908, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; GABA Modulators; Male; Neurons; Preoptic Area; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Sleep, REM

2001
High-dose flumazenil potentiates the hypnotic activity of propofol, but not that of thiopental, in ddY mice.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Drug Synergism; Flumazenil; GABA Modulators; Hypnotics and Sedatives; Male; Mice; Midazolam; Propofol; Thiopental

2001
Inhibitory effect of propofol on ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices is mediated by GABAA receptor activation.
    Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:3

    Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Bicuculline; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Antagonists; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gene Expression Regulation; Genes, fos; Gyrus Cinguli; Hemodynamics; Image Processing, Computer-Assisted; Immunohistochemistry; Ketamine; Male; Propofol; Rats; Rats, Wistar

2003
Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:5

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Gas Analysis; Brain; Carbon Dioxide; Electrocardiography; Electroencephalography; Flumazenil; GABA Modulators; Hemodynamics; Humans; Male; Methyl Ethers; Models, Biological; Oxygen; Positron-Emission Tomography; Propofol; Receptors, GABA-A; Reflex; Sevoflurane; Tissue Distribution

2004
Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Cyclohexanols; Flumazenil; Flunitrazepam; Menthol; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Xenopus

2008
[Patient awakening from anesthesia was re-sedated by administration of flumazenil].
    Masui. The Japanese journal of anesthesiology, 2008, Volume: 57, Issue:7

    Topics: Aged, 80 and over; Anesthesia Recovery Period; Drug Synergism; Female; Flumazenil; Humans; Hypnotics and Sedatives; Midazolam; Propofol

2008
[Transient decerebrate rigidity from hypoxemia during administration of propofol, midazolam-flumazenil, and remifentanil-naloxone].
    Revista espanola de anestesiologia y reanimacion, 2010, Volume: 57, Issue:2

    Topics: Airway Obstruction; Anesthetics, Intravenous; Bradycardia; Cardiotonic Agents; Cholangiopancreatography, Endoscopic Retrograde; Choledocholithiasis; Decerebrate State; Flumazenil; GABA Agonists; Humans; Hypnotics and Sedatives; Hypoxia; Intraoperative Complications; Intubation, Intratracheal; Male; Midazolam; Middle Aged; Naloxone; Piperidines; Propofol; Remifentanil; Sleep Apnea, Obstructive

2010
Effects of a novel benzodiazepine derivative, JM-1232(-), on human gastroepiploic artery in vitro.
    Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:1

    Topics: Dose-Response Relationship, Drug; Endothelium, Vascular; Flumazenil; GABA Modulators; Gastroepiploic Artery; Humans; In Vitro Techniques; Isoindoles; Midazolam; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Narcotic Antagonists; Norepinephrine; Piperazines; Potassium; Propofol; Structure-Activity Relationship; Vasoconstrictor Agents

2011
[Case report: a 65-year-old man loses consciousness after colonoscopy].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2010, Volume: 45, Issue:7-8

    Topics: Aged; Ambulatory Care; Anesthetics, Intravenous; Atropine; Bradycardia; Cholinergic Antagonists; Colonoscopy; Conscious Sedation; Diagnosis, Differential; Emergency Medical Services; Flumazenil; GABA Modulators; Hospitals, Rural; Humans; Hypnotics and Sedatives; Male; Midazolam; Muscarinic Antagonists; Propofol; Telephone; Unconsciousness

2010
Postoperative global amnesia reversed with flumazenil.
    The neurologist, 2012, Volume: 18, Issue:4

    Topics: Amnesia; Analgesics; Anesthesia, General; Cholangiopancreatography, Endoscopic Retrograde; Desflurane; Diabetes Mellitus, Type 2; Fentanyl; Flumazenil; GABA Modulators; Humans; Hydromorphone; Isoflurane; Male; Midazolam; Middle Aged; Pancreatitis; Postoperative Complications; Propofol

2012
[Improvement of consciousness by administration of flumazenil in a patient with unexpectedly delayed emergence from general anesthesia].
    Masui. The Japanese journal of anesthesiology, 2013, Volume: 62, Issue:4

    Topics: Anesthesia Recovery Period; Anesthesia, General; Consciousness; Female; Flumazenil; Humans; Middle Aged; Piperidines; Propofol; Remifentanil

2013
Sedation-associated complications in endoscopy are not reduced significantly by implementation of the German S-3-guideline and occur in a severe manner only in patients with ASA class III and higher.
    Scandinavian journal of gastroenterology, 2013, Volume: 48, Issue:9

    Topics: Antidotes; Apnea; Critical Care; Deep Sedation; Delivery of Health Care; Endoscopy, Gastrointestinal; Flumazenil; Germany; Guidelines as Topic; Health Status; Humans; Hypnotics and Sedatives; Personnel Staffing and Scheduling; Propofol; Retrospective Studies

2013
Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:2

    Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Brain; Caspases; Cell Line, Tumor; Cognition; Disease Models, Animal; Flumazenil; GABA Agonists; GABA Antagonists; Humans; Maze Learning; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nootropic Agents; Propofol; Random Allocation

2014
The Direct Actions of GABA, 2'-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Anesthetics, Intravenous; Animals; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Etomidate; Female; Flavones; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Humans; Propofol; Protein Subunits; Receptors, GABA-A; Xenopus laevis; Zinc Compounds

2015
Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Anesthetics; Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Interactions; Drug Synergism; Etomidate; Flumazenil; Humans; Kava; Mutation; Propofol; Protein Subunits; Pyrones; Receptors, GABA-A; Xenopus laevis

2016
Aminophylline and Ephedrine, but Not Flumazenil, Inhibit the Activity of the Excitatory Amino Acid Transporter 3 Expressed in
    BioMed research international, 2018, Volume: 2018

    Topics: Aminophylline; Animals; Ephedrine; Excitatory Amino Acid Transporter 3; Flumazenil; Gene Expression Regulation, Developmental; Glutamic Acid; Oocytes; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Propofol; Protein Kinase C; Protein Kinase Inhibitors; Xenopus laevis

2018
Shared structural mechanisms of general anaesthetics and benzodiazepines.
    Nature, 2020, Volume: 585, Issue:7824

    Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A

2020
JM-1232(-) and propofol, a new combination of hypnotics with short-acting and non-cumulative preferable properties.
    Experimental animals, 2021, Feb-06, Volume: 70, Issue:1

    Topics: Anesthesia Recovery Period; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Flumazenil; GABA-A Receptor Agonists; Hypnotics and Sedatives; Infusions, Intravenous; Isoindoles; Male; Mice, Inbred Strains; Piperazines; Propofol

2021
Recall of extubation after remimazolam anesthesia with flumazenil antagonism during emergence: a retrospective clinical study.
    Journal of anesthesia, 2022, Volume: 36, Issue:6

    Topics: Airway Extubation; Anesthesia, General; Flumazenil; Humans; Propofol; Retrospective Studies

2022