propofol has been researched along with bicuculline in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (34.04) | 18.2507 |
| 2000's | 25 (53.19) | 29.6817 |
| 2010's | 4 (8.51) | 24.3611 |
| 2020's | 2 (4.26) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Dolin, SJ; Morris, PJ; Smith, MB; Soar, J | 1 |
| Biggio, G; Concas, A; Gessa, GL; Peduto, VA; Santoro, G | 1 |
| Ahmad, I; Pleuvry, BJ | 1 |
| Garau, F; Harris, RA; Sanna, E | 1 |
| Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Santoro, G | 1 |
| Rasmussen, PA; Rutecki, PA; Yang, Y | 1 |
| Simmonds, MA; Zhong, Y | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M | 1 |
| Feng, JQ; Kendig, JJ | 1 |
| Kikuchi, T; Okumura, F; Sato, K; Wang, Y | 1 |
| Hemmings, HC; Murugaiah, KD | 1 |
| Guertin, PA; Hounsgaard, J | 1 |
| Akahori, F; Kounenis, G; Koutsoviti-Papadopoulou, M; Nikolaidis, E | 1 |
| Chen, CL; Chiu, TH; Yang, YR | 1 |
| Dohi, T; Irifune, M; Kawahara, M; Maeoka, K; Nishikawa, T; Shimizu, Y; Sugimura, M; Takarada, T | 1 |
| Buggy, DJ; Lambert, DG; Nicol, B; Rowbotham, DJ | 1 |
| Antkowiak, B; Hentschke, H | 1 |
| Bai, D; Jackson, MF; MacDonald, JF; Orser, BA; Pennefather, P; Zhu, G | 1 |
| Eintrei, C; Massoumi, R; Oscarsson, A; Sjölander, A | 1 |
| Chen, JT; Cheng, JT; Chou, AK; Lee, TC; Lin, CR; Lin, FC; Yang, LC | 1 |
| Dong, XP; Xu, TL | 1 |
| Abaigar, W; Bovill, JG; Laster, MJ; Sonner, JM; Stabernack, C; Xing, Y; Zhang, Y | 1 |
| Masuzawa, M; Miyamoto, E; Murayama, T; Nagata, A; Nakao, S; Shingu, K | 1 |
| Bieda, MC; MacIver, MB | 1 |
| Kashiwagi, M; Kuwana, SI; Ochiai, R; Okada, Y; Sakuraba, S; Takeda, J | 1 |
| Namiki, A; Ohmori, H; Sato, Y | 1 |
| Antkowiak, B; Grasshoff, C | 1 |
| Cao, JL; Dai, TJ; Wang, QY; Zeng, YM | 1 |
| Andreeva, N; Garret, M; Haas, HL; Scherer, A; Sergeeva, OA | 1 |
| Kiddoo, CE; Lukatch, HS; Maciver, MB | 1 |
| Goiny, M; Grasshoff, C; Herrera-Marschitz, M; Kretschmer, BD | 1 |
| Bayliss, DA; Chen, X; Shu, S | 1 |
| Abbas, SY; Goldstein, PA; Harrison, NL; Ying, SW | 1 |
| Eintrei, C; Juhas, M; Oscarsson, A; Sjölander, A | 1 |
| Björnström, K; Eintrei, C; Loitto, VM; Sundqvist, T; Turina, D | 1 |
| Ren, Y; Xue, QS; Yu, BW; Zhang, FJ; Zhao, X | 1 |
| Fong, W; Kamath, S; Kidambi, S; Nahmias, Y; Schianodicola, J; Yarmush, J | 1 |
| Andresen, MC; Jin, YH; Mendelowitz, D; Zhang, Z | 1 |
| Chai, CY; Wu, WC; Yang, CY | 1 |
| Lai, MJ; Lian, QQ; Wang, BF; Yang, B; Yang, XW; Zhang, FQ; Zhou, WH | 1 |
| Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Kim, YJ; Lee, GS; Lee, JU; Pandit, S; Park, JB; Song, JG | 1 |
| Wang, C; Yu, T; Zhang, L; Zhang, Y | 1 |
| Bajrektarevic, D; Nistri, A | 1 |
| Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y | 1 |
| An, L; Chen, T; Guo, S; Huang, X; Liu, L; Mei, Q; Sun, X; Tian, H; Wang, R; Zhao, Y | 1 |
47 other study(ies) available for propofol and bicuculline
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Does glycine antagonism underlie the excitatory effects of methohexitone and propofol?
Topics: Anesthesia, General; Animals; Bicuculline; Central Nervous System; Electroencephalography; Ethanol; Glycine; Male; Methohexital; Mice; Mice, Inbred Strains; Pentobarbital; Propofol; Seizures; Strychnine | 1992 |
Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membrane Proteins; Propofol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1991 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fentanyl; Kainic Acid; Meperidine; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Propofol; Seizures | 1995 |
Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital.
Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Propofol; Receptors, GABA-A; Strychnine; Xenopus laevis | 1995 |
Effects of propofol, pentobarbital and alphaxalone on t-[35S]butylbicyclophosphorothionate binding in rat cerebral cortex.
Topics: Anesthetics; Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes | 1994 |
Propofol inhibits epileptiform activity in rat hippocampal slices.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Convulsants; Drug Evaluation, Preclinical; Epilepsy; GABA Antagonists; Hypnotics and Sedatives; In Vitro Techniques; Male; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley | 1996 |
Pharmacological characterisation of multiple components in the enhancement by pregnanolone and propofol of [3H]flunitrazepam binding to GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Flunitrazepam; GABA Agonists; GABA Modulators; In Vitro Techniques; Male; Muscimol; Pregnanolone; Progesterone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Membranes | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 1996 |
Propofol potentiates the depressant effect of alfentanil in isolated neonatal rat spinal cord and blocks naloxone-precipitated hyperresponsiveness.
Topics: Alfentanil; Analgesics, Opioid; Anesthetics, Intravenous; Animals; Animals, Newborn; Bicuculline; Depression, Chemical; Drug Synergism; Evoked Potentials; GABA Antagonists; Naloxone; Narcotic Antagonists; Propofol; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
In vivo effects of propofol on acetylcholine release from the frontal cortex, hippocampus and striatum studied by intracerebral microdialysis in freely moving rats.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Corpus Striatum; Frontal Lobe; GABA Antagonists; Hippocampus; Male; Microdialysis; Movement; Propofol; Rats; Rats, Sprague-Dawley | 1998 |
Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes.
Topics: Aminobutyrates; Anesthesia, General; Anesthetics, Intravenous; Animals; Baclofen; Bicuculline; Calcium; Cerebral Cortex; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Nerve Endings; Nipecotic Acids; Picrotoxin; Potassium Chloride; Proline; Propofol; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Synaptic Transmission; Synaptosomes; Tritium | 1998 |
Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Bicuculline; Calcium Channel Agonists; Calcium Channels; Calcium Channels, L-Type; Excitatory Postsynaptic Potentials; GABA Antagonists; Interneurons; Motor Neurons; Pentobarbital; Propofol; Receptors, GABA-A; Serotonin; Spinal Cord; Tetrodotoxin; Thiopental; Turtles | 1999 |
Propofol's biphasic effect on GABA(A)-receptor-mediated response of the isolated guinea pig ileum.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Bicuculline; Dose-Response Relationship, Drug; Female; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; Male; Muscle Contraction; Propofol; Receptors, GABA-A; Vasodilator Agents | 1999 |
Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone.
Topics: Anesthetics; Anesthetics, Intravenous; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazepam; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ionophores; Locus Coeruleus; Male; Neurons; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc Compounds | 1999 |
Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline.
Topics: Anesthetics, Local; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; GABA Agonists; GABA Antagonists; Male; Mice; Muscimol; Propofol; Reflex | 1999 |
Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cerebral Cortex; Female; GABA Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; In Vitro Techniques; Ketamine; Neurons; Potassium; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Thiopental | 2000 |
[Effects of benzodiazepines and general anesthetics on the GABA A receptor: where are the differences?].
Topics: Anesthetics, General; Anesthetics, Inhalation; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Diazepam; Enflurane; Halothane; Isoflurane; Neocortex; Propofol; Rats; Receptors, GABA-A | 2000 |
Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.
Topics: Animals; Bicuculline; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Mice; Midazolam; Models, Neurological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Propofol; Pyridazines; Receptors, GABA-A | 2001 |
Reorganization of actin in neurons after propofol exposure.
Topics: Actins; Anesthetics, Intravenous; Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; GABA Antagonists; Immunoblotting; Neurons; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spectrometry, Fluorescence | 2001 |
Effect of thiopental, propofol, and etomidate on vincristine toxicity in PC12 cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bicuculline; Cytoprotection; Dose-Response Relationship, Drug; Drug Antagonism; Etomidate; GABA Antagonists; Nerve Growth Factor; Neurotoxicity Syndromes; PC12 Cells; Propofol; Rats; Thiopental; Vincristine | 2002 |
The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Chloride Channels; Dose-Response Relationship, Drug; Female; GABA Antagonists; Glycine Agents; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Patch-Clamp Techniques; Posterior Horn Cells; Propofol; Rats; Receptors, GABA-A; Receptors, Glycine; Strychnine | 2002 |
GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.
Topics: Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Glycine Agents; Infusions, Intravenous; Injections, Intraperitoneal; Isoflurane; Ketamine; Male; Picrotoxin; Propofol; Pulmonary Alveoli; Pyridazines; Rats; Rats, Sprague-Dawley; Strychnine | 2003 |
Inhibitory effect of propofol on ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices is mediated by GABAA receptor activation.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Bicuculline; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Antagonists; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gene Expression Regulation; Genes, fos; Gyrus Cinguli; Hemodynamics; Image Processing, Computer-Assisted; Immunohistochemistry; Ketamine; Male; Propofol; Rats; Rats, Wistar | 2003 |
Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission | 2004 |
A neuronal mechanism of propofol-induced central respiratory depression in newborn rats.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Bicuculline; Central Nervous System Depressants; Depression, Chemical; Female; GABA Antagonists; Male; Medulla Oblongata; Membrane Potentials; Neurons; Patch-Clamp Techniques; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Respiratory Mechanics; Spinal Cord; Spinal Nerve Roots | 2004 |
The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aminophylline; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theobromine; Xanthines | 2004 |
Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets.
Topics: Action Potentials; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Electrophysiology; Female; GABA Antagonists; Glycine Agents; Methyl Ethers; Neurons; Pregnancy; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Sevoflurane; Spinal Cord; Strychnine | 2004 |
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Propofol; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord | 2004 |
Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Diazepam; Electrophysiology; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Neurons; Neuropeptides; Orexin Receptors; Orexins; Propofol; Pyridazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide | 2005 |
Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission.
Topics: Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Carbachol; Electroencephalography; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Isoflurane; Kinetics; Male; Patch-Clamp Techniques; Propofol; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptic Transmission; Thiopental | 2005 |
Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Chromatography, High Pressure Liquid; Dialysis; Dopamine; GABA Antagonists; Glutamic Acid; Hallucinations; Male; Neurons; Propofol; Rats; Rats, Sprague-Dawley; Sexual Dysfunctions, Psychological; Telencephalon | 2005 |
Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons.
Topics: Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cerebral Cortex; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Female; GABA Antagonists; Glycine Agents; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channel Gating; Ion Channels; Lysine; Male; Membrane Potentials; Mice; Neural Inhibition; Neural Pathways; Oocytes; Patch-Clamp Techniques; Potassium Channels; Propofol; Pyramidal Cells; Pyrimidines; Rats; Strychnine; Thalamus; Time Factors; Xenopus | 2005 |
Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Bicuculline; Cell Count; Cyclic AMP; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Free Radical Scavengers; GABA Antagonists; Gene Expression; Glutamic Acid; Green Fluorescent Proteins; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; In Vitro Techniques; Ion Channels; Membrane Potentials; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periodicity; Potassium Channels; Propofol; Pyrimidines; Thalamus; Transfection | 2006 |
The effect of propofol on actin, ERK-1/2 and GABAA receptor content in neurones.
Topics: Actins; Anesthetics, Intravenous; Animals; Bicuculline; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Neurons; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2007 |
Propofol causes neurite retraction in neurones.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; GABA Antagonists; Heterocyclic Compounds, 4 or More Rings; Neurites; Phalloidine; Propofol; Rats; Rats, Sprague-Dawley | 2008 |
Bilateral inhibition of gamma-aminobutyric acid type A receptor function within the basolateral amygdala blocked propofol-induced amnesia and activity-regulated cytoskeletal protein expression inhibition in the hippocampus.
Topics: Amnesia; Amygdala; Animals; Bicuculline; Cytoskeletal Proteins; Functional Laterality; GABA-A Receptor Antagonists; Gene Expression Regulation; Hippocampus; Male; Neural Inhibition; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2008 |
Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells.
Topics: Animals; Bicuculline; Blotting, Western; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; GABA Agents; GABA Antagonists; GABA-A Receptor Antagonists; Genes, fos; Mice; Neurons; Polymerase Chain Reaction; Propofol; Proto-Oncogene Proteins c-fos; Transcription, Genetic | 2009 |
Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Furosemide; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Presynaptic Terminals; Propofol; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium Potassium Chloride Symporter Inhibitors; Solitary Nucleus; Synaptic Transmission | 2009 |
Modulation of propofol on the effects of blood pressure and firing activity of related neurons in the medulla.
Topics: Animals; Bicuculline; Blood Pressure; Cats; Female; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenic Acid; Male; Medulla Oblongata; Neurons; Propofol | 2009 |
Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Bicuculline; Male; Microinjections; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Self Administration | 2011 |
Attenuated benzodiazepine-sensitive tonic GABAA currents of supraoptic magnocellular neuroendocrine cells in 24-h water-deprived rats.
Topics: Animals; Bicuculline; Diazepam; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neuroendocrine Cells; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Supraoptic Nucleus; Water Deprivation | 2014 |
GABAA receptor in the thalamic specific relay system contributes to the propofol-induced somatosensory cortical suppression in rat.
Topics: Afferent Pathways; Anesthetics, Intravenous; Animals; Bicuculline; Evoked Potentials, Somatosensory; Female; GABA-A Receptor Antagonists; Male; Propofol; Rats; Receptors, GABA-A; Somatosensory Cortex; Synaptic Transmission; Thalamus; Ventral Thalamic Nuclei | 2013 |
Delayed application of the anesthetic propofol contrasts the neurotoxic effects of kainate on rat organotypic spinal slice cultures.
Topics: Animals; Bicuculline; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA-A Receptor Antagonists; Glycine Agents; Hypnotics and Sedatives; In Vitro Techniques; Kainic Acid; Organ Culture Techniques; Phosphopyruvate Hydratase; Propofol; Rats; Spinal Cord; Strychnine; Time Factors | 2016 |
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A | 2020 |
LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroencephalography; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Mice; Muscarinic Agonists; Pentylenetetrazole; Phenols; Pilocarpine; Propofol; Rats; Receptors, GABA-A; Seizures; Status Epilepticus | 2021 |