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propofol and bicuculline

propofol has been researched along with bicuculline in 47 studies

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (34.04)18.2507
2000's25 (53.19)29.6817
2010's4 (8.51)24.3611
2020's2 (4.26)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Dolin, SJ; Morris, PJ; Smith, MB; Soar, J1
Biggio, G; Concas, A; Gessa, GL; Peduto, VA; Santoro, G1
Ahmad, I; Pleuvry, BJ1
Garau, F; Harris, RA; Sanna, E1
Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Santoro, G1
Rasmussen, PA; Rutecki, PA; Yang, Y1
Simmonds, MA; Zhong, Y1
Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF1
Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M1
Feng, JQ; Kendig, JJ1
Kikuchi, T; Okumura, F; Sato, K; Wang, Y1
Hemmings, HC; Murugaiah, KD1
Guertin, PA; Hounsgaard, J1
Akahori, F; Kounenis, G; Koutsoviti-Papadopoulou, M; Nikolaidis, E1
Chen, CL; Chiu, TH; Yang, YR1
Dohi, T; Irifune, M; Kawahara, M; Maeoka, K; Nishikawa, T; Shimizu, Y; Sugimura, M; Takarada, T1
Buggy, DJ; Lambert, DG; Nicol, B; Rowbotham, DJ1
Antkowiak, B; Hentschke, H1
Bai, D; Jackson, MF; MacDonald, JF; Orser, BA; Pennefather, P; Zhu, G1
Eintrei, C; Massoumi, R; Oscarsson, A; Sjölander, A1
Chen, JT; Cheng, JT; Chou, AK; Lee, TC; Lin, CR; Lin, FC; Yang, LC1
Dong, XP; Xu, TL1
Abaigar, W; Bovill, JG; Laster, MJ; Sonner, JM; Stabernack, C; Xing, Y; Zhang, Y1
Masuzawa, M; Miyamoto, E; Murayama, T; Nagata, A; Nakao, S; Shingu, K1
Bieda, MC; MacIver, MB1
Kashiwagi, M; Kuwana, SI; Ochiai, R; Okada, Y; Sakuraba, S; Takeda, J1
Namiki, A; Ohmori, H; Sato, Y1
Antkowiak, B; Grasshoff, C1
Cao, JL; Dai, TJ; Wang, QY; Zeng, YM1
Andreeva, N; Garret, M; Haas, HL; Scherer, A; Sergeeva, OA1
Kiddoo, CE; Lukatch, HS; Maciver, MB1
Goiny, M; Grasshoff, C; Herrera-Marschitz, M; Kretschmer, BD1
Bayliss, DA; Chen, X; Shu, S1
Abbas, SY; Goldstein, PA; Harrison, NL; Ying, SW1
Eintrei, C; Juhas, M; Oscarsson, A; Sjölander, A1
Björnström, K; Eintrei, C; Loitto, VM; Sundqvist, T; Turina, D1
Ren, Y; Xue, QS; Yu, BW; Zhang, FJ; Zhao, X1
Fong, W; Kamath, S; Kidambi, S; Nahmias, Y; Schianodicola, J; Yarmush, J1
Andresen, MC; Jin, YH; Mendelowitz, D; Zhang, Z1
Chai, CY; Wu, WC; Yang, CY1
Lai, MJ; Lian, QQ; Wang, BF; Yang, B; Yang, XW; Zhang, FQ; Zhou, WH1
Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Kim, YJ; Lee, GS; Lee, JU; Pandit, S; Park, JB; Song, JG1
Wang, C; Yu, T; Zhang, L; Zhang, Y1
Bajrektarevic, D; Nistri, A1
Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y1
An, L; Chen, T; Guo, S; Huang, X; Liu, L; Mei, Q; Sun, X; Tian, H; Wang, R; Zhao, Y1

Other Studies

47 other study(ies) available for propofol and bicuculline

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Does glycine antagonism underlie the excitatory effects of methohexitone and propofol?
    British journal of anaesthesia, 1992, Volume: 68, Issue:5

    Topics: Anesthesia, General; Animals; Bicuculline; Central Nervous System; Electroencephalography; Ethanol; Glycine; Male; Methohexital; Mice; Mice, Inbred Strains; Pentobarbital; Propofol; Seizures; Strychnine

1992
Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain.
    Anesthesiology, 1991, Volume: 75, Issue:6

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membrane Proteins; Propofol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission

1991
Interactions between opioid drugs and propofol in laboratory models of seizures.
    British journal of anaesthesia, 1995, Volume: 74, Issue:3

    Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fentanyl; Kainic Acid; Meperidine; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Propofol; Seizures

1995
Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital.
    Molecular pharmacology, 1995, Volume: 47, Issue:2

    Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Propofol; Receptors, GABA-A; Strychnine; Xenopus laevis

1995
Effects of propofol, pentobarbital and alphaxalone on t-[35S]butylbicyclophosphorothionate binding in rat cerebral cortex.
    European journal of pharmacology, 1994, Apr-15, Volume: 267, Issue:2

    Topics: Anesthetics; Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes

1994
Propofol inhibits epileptiform activity in rat hippocampal slices.
    Epilepsy research, 1996, Volume: 25, Issue:3

    Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Convulsants; Drug Evaluation, Preclinical; Epilepsy; GABA Antagonists; Hypnotics and Sedatives; In Vitro Techniques; Male; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley

1996
Pharmacological characterisation of multiple components in the enhancement by pregnanolone and propofol of [3H]flunitrazepam binding to GABAA receptors.
    Neuropharmacology, 1996, Volume: 35, Issue:9-10

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Flunitrazepam; GABA Agonists; GABA Modulators; In Vitro Techniques; Male; Muscimol; Pregnanolone; Progesterone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Membranes

1996
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
    Nature, 1997, Feb-27, Volume: 385, Issue:6619

    Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection

1997
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
    Neuropharmacology, 1996, Volume: 35, Issue:12

    Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis

1996
Propofol potentiates the depressant effect of alfentanil in isolated neonatal rat spinal cord and blocks naloxone-precipitated hyperresponsiveness.
    Neuroscience letters, 1997, Jun-20, Volume: 229, Issue:1

    Topics: Alfentanil; Analgesics, Opioid; Anesthetics, Intravenous; Animals; Animals, Newborn; Bicuculline; Depression, Chemical; Drug Synergism; Evoked Potentials; GABA Antagonists; Naloxone; Narcotic Antagonists; Propofol; Rats; Rats, Sprague-Dawley; Spinal Cord

1997
In vivo effects of propofol on acetylcholine release from the frontal cortex, hippocampus and striatum studied by intracerebral microdialysis in freely moving rats.
    British journal of anaesthesia, 1998, Volume: 80, Issue:5

    Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Corpus Striatum; Frontal Lobe; GABA Antagonists; Hippocampus; Male; Microdialysis; Movement; Propofol; Rats; Rats, Sprague-Dawley

1998
Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes.
    Anesthesiology, 1998, Volume: 89, Issue:4

    Topics: Aminobutyrates; Anesthesia, General; Anesthetics, Intravenous; Animals; Baclofen; Bicuculline; Calcium; Cerebral Cortex; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Nerve Endings; Nipecotic Acids; Picrotoxin; Potassium Chloride; Proline; Propofol; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Synaptic Transmission; Synaptosomes; Tritium

1998
Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials.
    Neuroscience, 1999, Volume: 88, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Bicuculline; Calcium Channel Agonists; Calcium Channels; Calcium Channels, L-Type; Excitatory Postsynaptic Potentials; GABA Antagonists; Interneurons; Motor Neurons; Pentobarbital; Propofol; Receptors, GABA-A; Serotonin; Spinal Cord; Tetrodotoxin; Thiopental; Turtles

1999
Propofol's biphasic effect on GABA(A)-receptor-mediated response of the isolated guinea pig ileum.
    Pharmacological research, 1999, Volume: 40, Issue:4

    Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Bicuculline; Dose-Response Relationship, Drug; Female; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; Male; Muscle Contraction; Propofol; Receptors, GABA-A; Vasodilator Agents

1999
Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone.
    European journal of pharmacology, 1999, Dec-15, Volume: 386, Issue:2-3

    Topics: Anesthetics; Anesthetics, Intravenous; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazepam; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ionophores; Locus Coeruleus; Male; Neurons; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc Compounds

1999
Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline.
    British journal of anaesthesia, 1999, Volume: 83, Issue:4

    Topics: Anesthetics, Local; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; GABA Agonists; GABA Antagonists; Male; Mice; Muscimol; Propofol; Reflex

1999
Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition.
    Anesthesiology, 2000, Volume: 92, Issue:4

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cerebral Cortex; Female; GABA Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; In Vitro Techniques; Ketamine; Neurons; Potassium; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Thiopental

2000
[Effects of benzodiazepines and general anesthetics on the GABA A receptor: where are the differences?].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2000, Volume: 35, Issue:9

    Topics: Anesthetics, General; Anesthetics, Inhalation; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Diazepam; Enflurane; Halothane; Isoflurane; Neocortex; Propofol; Rats; Receptors, GABA-A

2000
Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.
    Molecular pharmacology, 2001, Volume: 59, Issue:4

    Topics: Animals; Bicuculline; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Mice; Midazolam; Models, Neurological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Propofol; Pyridazines; Receptors, GABA-A

2001
Reorganization of actin in neurons after propofol exposure.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:10

    Topics: Actins; Anesthetics, Intravenous; Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; GABA Antagonists; Immunoblotting; Neurons; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spectrometry, Fluorescence

2001
Effect of thiopental, propofol, and etomidate on vincristine toxicity in PC12 cells.
    Cell biology and toxicology, 2002, Volume: 18, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bicuculline; Cytoprotection; Dose-Response Relationship, Drug; Drug Antagonism; Etomidate; GABA Antagonists; Nerve Growth Factor; Neurotoxicity Syndromes; PC12 Cells; Propofol; Rats; Thiopental; Vincristine

2002
The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:4

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Chloride Channels; Dose-Response Relationship, Drug; Female; GABA Antagonists; Glycine Agents; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Patch-Clamp Techniques; Posterior Horn Cells; Propofol; Rats; Receptors, GABA-A; Receptors, Glycine; Strychnine

2002
GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:3

    Topics: Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Glycine Agents; Infusions, Intravenous; Injections, Intraperitoneal; Isoflurane; Ketamine; Male; Picrotoxin; Propofol; Pulmonary Alveoli; Pyridazines; Rats; Rats, Sprague-Dawley; Strychnine

2003
Inhibitory effect of propofol on ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices is mediated by GABAA receptor activation.
    Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:3

    Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Bicuculline; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Antagonists; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Gene Expression Regulation; Genes, fos; Gyrus Cinguli; Hemodynamics; Image Processing, Computer-Assisted; Immunohistochemistry; Ketamine; Male; Propofol; Rats; Rats, Wistar

2003
Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability.
    Journal of neurophysiology, 2004, Volume: 92, Issue:3

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission

2004
A neuronal mechanism of propofol-induced central respiratory depression in newborn rats.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Bicuculline; Central Nervous System Depressants; Depression, Chemical; Female; GABA Antagonists; Male; Medulla Oblongata; Membrane Potentials; Neurons; Patch-Clamp Techniques; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Respiratory Mechanics; Spinal Cord; Spinal Nerve Roots

2004
The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:4

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aminophylline; Anesthetics, Intravenous; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theobromine; Xanthines

2004
Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets.
    Anesthesiology, 2004, Volume: 101, Issue:5

    Topics: Action Potentials; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Electrophysiology; Female; GABA Antagonists; Glycine Agents; Methyl Ethers; Neurons; Pregnancy; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Sevoflurane; Spinal Cord; Strychnine

2004
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:12

    Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Propofol; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord

2004
Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jan-05, Volume: 25, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Diazepam; Electrophysiology; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Neurons; Neuropeptides; Orexin Receptors; Orexins; Propofol; Pyridazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide

2005
Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission.
    Cerebral cortex (New York, N.Y. : 1991), 2005, Volume: 15, Issue:9

    Topics: Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Carbachol; Electroencephalography; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Isoflurane; Kinetics; Male; Patch-Clamp Techniques; Propofol; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptic Transmission; Thiopental

2005
Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis.
    Amino acids, 2005, Volume: 28, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Chromatography, High Pressure Liquid; Dialysis; Dopamine; GABA Antagonists; Glutamic Acid; Hallucinations; Male; Neurons; Propofol; Rats; Rats, Sprague-Dawley; Sexual Dysfunctions, Psychological; Telencephalon

2005
Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons.
    Journal of neurophysiology, 2005, Volume: 94, Issue:6

    Topics: Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cerebral Cortex; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Female; GABA Antagonists; Glycine Agents; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channel Gating; Ion Channels; Lysine; Male; Membrane Potentials; Mice; Neural Inhibition; Neural Pathways; Oocytes; Patch-Clamp Techniques; Potassium Channels; Propofol; Pyramidal Cells; Pyrimidines; Rats; Strychnine; Thalamus; Time Factors; Xenopus

2005
Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.
    The European journal of neuroscience, 2006, Volume: 23, Issue:2

    Topics: Action Potentials; Analysis of Variance; Animals; Bicuculline; Cell Count; Cyclic AMP; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Free Radical Scavengers; GABA Antagonists; Gene Expression; Glutamic Acid; Green Fluorescent Proteins; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; In Vitro Techniques; Ion Channels; Membrane Potentials; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periodicity; Potassium Channels; Propofol; Pyrimidines; Thalamus; Transfection

2006
The effect of propofol on actin, ERK-1/2 and GABAA receptor content in neurones.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:9

    Topics: Actins; Anesthetics, Intravenous; Animals; Bicuculline; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Neurons; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2007
Propofol causes neurite retraction in neurones.
    British journal of anaesthesia, 2008, Volume: 101, Issue:3

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; GABA Antagonists; Heterocyclic Compounds, 4 or More Rings; Neurites; Phalloidine; Propofol; Rats; Rats, Sprague-Dawley

2008
Bilateral inhibition of gamma-aminobutyric acid type A receptor function within the basolateral amygdala blocked propofol-induced amnesia and activity-regulated cytoskeletal protein expression inhibition in the hippocampus.
    Anesthesiology, 2008, Volume: 109, Issue:5

    Topics: Amnesia; Amygdala; Animals; Bicuculline; Cytoskeletal Proteins; Functional Laterality; GABA-A Receptor Antagonists; Gene Expression Regulation; Hippocampus; Male; Neural Inhibition; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2008
Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells.
    Neuroreport, 2009, May-06, Volume: 20, Issue:7

    Topics: Animals; Bicuculline; Blotting, Western; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; GABA Agents; GABA Antagonists; GABA-A Receptor Antagonists; Genes, fos; Mice; Neurons; Polymerase Chain Reaction; Propofol; Proto-Oncogene Proteins c-fos; Transcription, Genetic

2009
Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons.
    Brain research, 2009, Aug-25, Volume: 1286

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Furosemide; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Presynaptic Terminals; Propofol; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium Potassium Chloride Symporter Inhibitors; Solitary Nucleus; Synaptic Transmission

2009
Modulation of propofol on the effects of blood pressure and firing activity of related neurons in the medulla.
    The Chinese journal of physiology, 2009, Nov-30, Volume: 52, Issue:5 Suppl

    Topics: Animals; Bicuculline; Blood Pressure; Cats; Female; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenic Acid; Male; Medulla Oblongata; Neurons; Propofol

2009
Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats.
    Acta pharmacologica Sinica, 2011, Volume: 32, Issue:12

    Topics: Anesthetics, Intravenous; Animals; Baclofen; Bicuculline; Male; Microinjections; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Self Administration

2011
Attenuated benzodiazepine-sensitive tonic GABAA currents of supraoptic magnocellular neuroendocrine cells in 24-h water-deprived rats.
    Journal of neuroendocrinology, 2014, Volume: 26, Issue:1

    Topics: Animals; Bicuculline; Diazepam; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neuroendocrine Cells; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Supraoptic Nucleus; Water Deprivation

2014
GABAA receptor in the thalamic specific relay system contributes to the propofol-induced somatosensory cortical suppression in rat.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Afferent Pathways; Anesthetics, Intravenous; Animals; Bicuculline; Evoked Potentials, Somatosensory; Female; GABA-A Receptor Antagonists; Male; Propofol; Rats; Receptors, GABA-A; Somatosensory Cortex; Synaptic Transmission; Thalamus; Ventral Thalamic Nuclei

2013
Delayed application of the anesthetic propofol contrasts the neurotoxic effects of kainate on rat organotypic spinal slice cultures.
    Neurotoxicology, 2016, Volume: 54

    Topics: Animals; Bicuculline; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA-A Receptor Antagonists; Glycine Agents; Hypnotics and Sedatives; In Vitro Techniques; Kainic Acid; Organ Culture Techniques; Phosphopyruvate Hydratase; Propofol; Rats; Spinal Cord; Strychnine; Time Factors

2016
Shared structural mechanisms of general anaesthetics and benzodiazepines.
    Nature, 2020, Volume: 585, Issue:7824

    Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A

2020
LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
    Epilepsia, 2021, Volume: 62, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroencephalography; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Mice; Muscarinic Agonists; Pentylenetetrazole; Phenols; Pilocarpine; Propofol; Rats; Receptors, GABA-A; Seizures; Status Epilepticus

2021